ZA200104410B - Novel bicyclic compounds. - Google Patents

Novel bicyclic compounds. Download PDF

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Publication number
ZA200104410B
ZA200104410B ZA200104410A ZA200104410A ZA200104410B ZA 200104410 B ZA200104410 B ZA 200104410B ZA 200104410 A ZA200104410 A ZA 200104410A ZA 200104410 A ZA200104410 A ZA 200104410A ZA 200104410 B ZA200104410 B ZA 200104410B
Authority
ZA
South Africa
Prior art keywords
benzofuran
methyl
pyridin
ylmethyl
propoxy
Prior art date
Application number
ZA200104410A
Other languages
English (en)
Inventor
Yuhko Aoki
Toshihiko Fujii
Pingli Liu
Ohtsuka Tatsuo Tatsuo
Hirosato Ebiike
Kenichi Kawasaki
Miyako Masubuchi
Shinji Tsujii
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of ZA200104410B publication Critical patent/ZA200104410B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
ZA200104410A 1998-12-18 2001-05-29 Novel bicyclic compounds. ZA200104410B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98124120 1998-12-18

Publications (1)

Publication Number Publication Date
ZA200104410B true ZA200104410B (en) 2002-08-29

Family

ID=8233179

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200104410A ZA200104410B (en) 1998-12-18 2001-05-29 Novel bicyclic compounds.

Country Status (18)

Country Link
US (1) US6376491B1 (zh)
EP (1) EP1149094B1 (zh)
JP (1) JP3435404B2 (zh)
KR (1) KR20010081117A (zh)
CN (1) CN1333770A (zh)
AR (1) AR021714A1 (zh)
AT (1) ATE264855T1 (zh)
AU (1) AU754233B2 (zh)
BR (1) BR9916318A (zh)
CA (1) CA2355694A1 (zh)
DE (1) DE69916664T2 (zh)
DK (1) DK1149094T3 (zh)
ES (1) ES2217882T3 (zh)
MX (1) MXPA01006218A (zh)
PE (1) PE20001324A1 (zh)
TR (1) TR200101779T2 (zh)
WO (1) WO2000037464A2 (zh)
ZA (1) ZA200104410B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2716369C (en) * 1999-05-24 2013-05-14 Mitsubishi Tanabe Pharma Corporation Phenoxypropylamine compounds
SE9902987D0 (sv) * 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
AU2002224105A1 (en) * 2000-11-27 2002-06-03 Mitsubishi Pharma Corporation Piperidine compounds and medicinal use thereof
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
WO2006015279A1 (en) * 2004-07-28 2006-02-09 Neurogen Corporation Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders
JPWO2007020936A1 (ja) * 2005-08-17 2009-02-26 第一三共株式会社 抗真菌作用二環性複素環化合物
US20090270496A1 (en) * 2007-05-03 2009-10-29 Courchesne William E Antifungal compounds
GB0815947D0 (en) 2008-09-02 2008-10-08 Univ Dundee Compounds
WO2010042998A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
CA2740484C (en) * 2008-10-17 2021-09-21 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
GB201120993D0 (en) 2011-12-06 2012-01-18 Imp Innovations Ltd Novel compounds and their use in therapy
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
CN107540725B (zh) * 2016-06-29 2020-04-07 孙青� 一种水溶性丹参酮ⅱa衍生物及其制备与应用
GB201820660D0 (en) 2018-12-19 2019-01-30 Imperial Innovations Ltd Cancer treatments
GB201820659D0 (en) 2018-12-19 2019-01-30 Imperial Innovations Ltd Novel compostions and their use in therapy
GB202014736D0 (en) 2020-09-18 2020-11-04 Imperial College Innovations Ltd Novel compounds and their use in therapy
GB202017367D0 (en) 2020-11-02 2020-12-16 Imperial College Innovations Ltd Novel use
WO2024052684A1 (en) 2022-09-09 2024-03-14 MyricX Pharma Limited Antibody drug conjugate comprising nmt inhibitor and its use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1129072A (en) * 1966-02-01 1968-10-02 Ici Ltd Benzofuran and indole derivatives
GB1256735A (zh) * 1969-03-06 1971-12-15
US3853923A (en) * 1971-05-13 1974-12-10 Kakenyaku Kako Kk 2-substituted-(2-hydroxy-3-lower alkaminopropoxy)-benzofurans
US4056626A (en) 1971-05-13 1977-11-01 Kakenyaku Kako Co., Ltd. Pharmaceutical composition containing benzofuran derivative
CA1089866A (en) * 1975-10-20 1980-11-18 Kiyoshi Ito Benzofuran derivatives, preparation thereof and pharmaceutical compositions thereof
SU671256A1 (ru) * 1977-06-08 1986-11-23 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Гидрохлорид 1-(2-карбэтокси-3-метилбензофуран-4-илокси-3-изопропиламино)-2-пропанола,обладающий антиаритмическим и @ -адреноблокирующим действием
JPS5740479A (en) * 1980-08-21 1982-03-06 Kaken Pharmaceut Co Ltd Preparation of benzofuran derivative and its acid addition salt
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US5082967A (en) * 1988-06-16 1992-01-21 Washington University Novel fatty acid analog enzyme substrates
FR2672598A1 (fr) * 1991-02-11 1992-08-14 Adir Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JPH07215940A (ja) * 1994-01-27 1995-08-15 Torii Yakuhin Kk 抗ウイルス活性を有する化合物
JPH08198826A (ja) * 1995-01-23 1996-08-06 Torii Yakuhin Kk 抗ウイルス活性を有する化合物

Also Published As

Publication number Publication date
PE20001324A1 (es) 2000-12-02
AU2660600A (en) 2000-07-12
US6376491B1 (en) 2002-04-23
EP1149094A2 (en) 2001-10-31
DK1149094T3 (da) 2004-08-16
WO2000037464A3 (en) 2000-11-02
KR20010081117A (ko) 2001-08-27
JP3435404B2 (ja) 2003-08-11
ES2217882T3 (es) 2004-11-01
EP1149094B1 (en) 2004-04-21
BR9916318A (pt) 2001-08-14
DE69916664T2 (de) 2005-03-31
CA2355694A1 (en) 2000-06-29
WO2000037464A2 (en) 2000-06-29
MXPA01006218A (es) 2002-04-17
JP2002533340A (ja) 2002-10-08
DE69916664D1 (de) 2004-05-27
AU754233B2 (en) 2002-11-07
TR200101779T2 (tr) 2001-12-21
ATE264855T1 (de) 2004-05-15
AR021714A1 (es) 2002-07-31
CN1333770A (zh) 2002-01-30

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