BR9916318A - Compostos bicìclicos - Google Patents
Compostos bicìclicosInfo
- Publication number
- BR9916318A BR9916318A BR9916318-7A BR9916318A BR9916318A BR 9916318 A BR9916318 A BR 9916318A BR 9916318 A BR9916318 A BR 9916318A BR 9916318 A BR9916318 A BR 9916318A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- bicyclic compounds
- bicyclical
- myristoyltransferase
- directed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Abstract
Patente de Invenção: <B>"COMPOSTOS BICìCLICOS"<D>. A presente invenção é direcionada aos novos compostos bicíclicos de fórmula [I], e seus sais farmaceuticamente aceitáveis, em que R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, Q^ 1^, Q^ 2^ e Q^ 3^ são conforme definidos nas reivindicações. Os compostos têm atividade inibitória de N-miristoiltransferase e antifungicida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98124120 | 1998-12-18 | ||
PCT/EP1999/009763 WO2000037464A2 (en) | 1998-12-18 | 1999-12-10 | 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9916318A true BR9916318A (pt) | 2001-08-14 |
Family
ID=8233179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9916318-7A BR9916318A (pt) | 1998-12-18 | 1999-12-10 | Compostos bicìclicos |
Country Status (18)
Country | Link |
---|---|
US (1) | US6376491B1 (pt) |
EP (1) | EP1149094B1 (pt) |
JP (1) | JP3435404B2 (pt) |
KR (1) | KR20010081117A (pt) |
CN (1) | CN1333770A (pt) |
AR (1) | AR021714A1 (pt) |
AT (1) | ATE264855T1 (pt) |
AU (1) | AU754233B2 (pt) |
BR (1) | BR9916318A (pt) |
CA (1) | CA2355694A1 (pt) |
DE (1) | DE69916664T2 (pt) |
DK (1) | DK1149094T3 (pt) |
ES (1) | ES2217882T3 (pt) |
MX (1) | MXPA01006218A (pt) |
PE (1) | PE20001324A1 (pt) |
TR (1) | TR200101779T2 (pt) |
WO (1) | WO2000037464A2 (pt) |
ZA (1) | ZA200104410B (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU777594B2 (en) * | 1999-05-24 | 2004-10-21 | Mitsubishi Pharma Corporation | Phenoxypropylamine compounds |
SE9902987D0 (sv) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
JP4042566B2 (ja) * | 2000-11-27 | 2008-02-06 | 田辺三菱製薬株式会社 | ピペリジン化合物およびその医薬用途 |
US7078541B2 (en) * | 2002-02-07 | 2006-07-18 | Galileo Pharmaceuticals, Inc. | Benzofuran derivatives |
US6653346B1 (en) * | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
WO2006015279A1 (en) * | 2004-07-28 | 2006-02-09 | Neurogen Corporation | Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders |
WO2007020936A1 (ja) * | 2005-08-17 | 2007-02-22 | Daiichi Sankyo Company, Limited | 抗真菌作用二環性複素環化合物 |
US20090270496A1 (en) * | 2007-05-03 | 2009-10-29 | Courchesne William E | Antifungal compounds |
GB0815947D0 (en) | 2008-09-02 | 2008-10-08 | Univ Dundee | Compounds |
CA2739901A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators |
ES2590904T3 (es) | 2008-10-17 | 2016-11-24 | Akaal Pharma Pty Ltd | Moduladores de receptores de S1P y uso de los mismos |
GB201120993D0 (en) | 2011-12-06 | 2012-01-18 | Imp Innovations Ltd | Novel compounds and their use in therapy |
GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
CN107540725B (zh) * | 2016-06-29 | 2020-04-07 | 孙青� | 一种水溶性丹参酮ⅱa衍生物及其制备与应用 |
GB201820660D0 (en) | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Cancer treatments |
GB201820659D0 (en) | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Novel compostions and their use in therapy |
GB202014736D0 (en) | 2020-09-18 | 2020-11-04 | Imperial College Innovations Ltd | Novel compounds and their use in therapy |
GB202017367D0 (en) | 2020-11-02 | 2020-12-16 | Imperial College Innovations Ltd | Novel use |
WO2024052684A1 (en) | 2022-09-09 | 2024-03-14 | MyricX Pharma Limited | Antibody drug conjugate comprising nmt inhibitor and its use |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1129072A (en) * | 1966-02-01 | 1968-10-02 | Ici Ltd | Benzofuran and indole derivatives |
GB1256735A (pt) * | 1969-03-06 | 1971-12-15 | ||
US3853923A (en) * | 1971-05-13 | 1974-12-10 | Kakenyaku Kako Kk | 2-substituted-(2-hydroxy-3-lower alkaminopropoxy)-benzofurans |
US4056626A (en) | 1971-05-13 | 1977-11-01 | Kakenyaku Kako Co., Ltd. | Pharmaceutical composition containing benzofuran derivative |
CA1089866A (en) * | 1975-10-20 | 1980-11-18 | Kiyoshi Ito | Benzofuran derivatives, preparation thereof and pharmaceutical compositions thereof |
SU671256A1 (ru) * | 1977-06-08 | 1986-11-23 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе | Гидрохлорид 1-(2-карбэтокси-3-метилбензофуран-4-илокси-3-изопропиламино)-2-пропанола,обладающий антиаритмическим и @ -адреноблокирующим действием |
JPS5740479A (en) * | 1980-08-21 | 1982-03-06 | Kaken Pharmaceut Co Ltd | Preparation of benzofuran derivative and its acid addition salt |
EP0146243A1 (en) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
US5082967A (en) * | 1988-06-16 | 1992-01-21 | Washington University | Novel fatty acid analog enzyme substrates |
FR2672598A1 (fr) * | 1991-02-11 | 1992-08-14 | Adir | Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
JPH07215940A (ja) * | 1994-01-27 | 1995-08-15 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
JPH08198826A (ja) * | 1995-01-23 | 1996-08-06 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
-
1999
- 1999-12-10 CA CA002355694A patent/CA2355694A1/en not_active Abandoned
- 1999-12-10 AT AT99968791T patent/ATE264855T1/de not_active IP Right Cessation
- 1999-12-10 KR KR1020017007661A patent/KR20010081117A/ko active IP Right Grant
- 1999-12-10 AU AU26606/00A patent/AU754233B2/en not_active Ceased
- 1999-12-10 DE DE69916664T patent/DE69916664T2/de not_active Expired - Fee Related
- 1999-12-10 WO PCT/EP1999/009763 patent/WO2000037464A2/en active IP Right Grant
- 1999-12-10 BR BR9916318-7A patent/BR9916318A/pt not_active IP Right Cessation
- 1999-12-10 JP JP2000589535A patent/JP3435404B2/ja not_active Expired - Fee Related
- 1999-12-10 MX MXPA01006218A patent/MXPA01006218A/es unknown
- 1999-12-10 EP EP99968791A patent/EP1149094B1/en not_active Expired - Lifetime
- 1999-12-10 ES ES99968791T patent/ES2217882T3/es not_active Expired - Lifetime
- 1999-12-10 CN CN99815722A patent/CN1333770A/zh active Pending
- 1999-12-10 DK DK99968791T patent/DK1149094T3/da active
- 1999-12-10 TR TR2001/01779T patent/TR200101779T2/xx unknown
- 1999-12-14 PE PE1999001249A patent/PE20001324A1/es not_active Application Discontinuation
- 1999-12-15 US US09/464,240 patent/US6376491B1/en not_active Expired - Fee Related
- 1999-12-16 AR ARP990106457A patent/AR021714A1/es not_active Application Discontinuation
-
2001
- 2001-05-29 ZA ZA200104410A patent/ZA200104410B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK1149094T3 (da) | 2004-08-16 |
AR021714A1 (es) | 2002-07-31 |
CA2355694A1 (en) | 2000-06-29 |
KR20010081117A (ko) | 2001-08-27 |
US6376491B1 (en) | 2002-04-23 |
AU754233B2 (en) | 2002-11-07 |
ATE264855T1 (de) | 2004-05-15 |
DE69916664T2 (de) | 2005-03-31 |
PE20001324A1 (es) | 2000-12-02 |
WO2000037464A3 (en) | 2000-11-02 |
EP1149094B1 (en) | 2004-04-21 |
JP3435404B2 (ja) | 2003-08-11 |
DE69916664D1 (de) | 2004-05-27 |
CN1333770A (zh) | 2002-01-30 |
WO2000037464A2 (en) | 2000-06-29 |
ZA200104410B (en) | 2002-08-29 |
MXPA01006218A (es) | 2002-04-17 |
EP1149094A2 (en) | 2001-10-31 |
JP2002533340A (ja) | 2002-10-08 |
AU2660600A (en) | 2000-07-12 |
TR200101779T2 (tr) | 2001-12-21 |
ES2217882T3 (es) | 2004-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9916318A (pt) | Compostos bicìclicos | |
BR9812010A (pt) | Determinados ácidos 5-alquil-2-arilaminofenilacéticos e derivados | |
TR199902606T2 (xx) | Farnesil transferaz� engelleyici kinazolinonlar. | |
TR200200579T2 (tr) | Amino-tirazolpiridin türevleri. | |
AU9309898A (en) | Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor xa | |
BG66085B1 (bg) | Фенилаланинови производни | |
BR9708632A (pt) | Composto calcilìticos | |
PT1413582E (pt) | Pirrolobenzodiazepinas dimericas | |
BR0109703A (pt) | Derivados de piperazina | |
BRPI0014076B8 (pt) | benzamidas e inibidores correlatos do fator xa | |
BR0210445A (pt) | Derivados de n-fenilpirrol guanidina como ligandos de receptor melanocortin | |
BRPI0412291A (pt) | antagonistas duplos de nka/nk3 para o tratamento de esquizofrenia | |
BR0108678A (pt) | Novos compostos | |
BR9810021A (pt) | Derivados 9-oxima-eritromicina | |
BR9800884A (pt) | Aplicação de derivados de pirimidina para a prevenção do câncer, por si só ou em combinação com outras medidas terapêuticas. | |
BR0110998A (pt) | Derivados de fenilglicina | |
TR200102489T2 (tr) | 3-Fenilpiridin Türevleri ve bunların NK-1 alıcı antagonistler olarak kullanılması | |
TR199900486T2 (xx) | Aziniloksi ve fenoksi-diaril-karbonasit t�revleri. | |
BR0210531A (pt) | Derivados de ácido sulfÈnico | |
BR9910908A (pt) | Indenopirrolocarbazóis ligados em ponte | |
YU52000A (sh) | Jedinjenja meta-azaciklične amino benzojeve kiseline i njihovi derivati, koji su antagonisti integrina | |
TR200200263T2 (tr) | Yeni seçiçi retinoid agonistleri | |
BR9812922A (pt) | Isoquinolinas como inibidores de uroquinase | |
NO995114L (no) | Festeanordning for å forbinde to deler med hverandre, samt anvendelse av festeanordningen | |
BR0014990A (pt) | Derivados de tetrahidrotiopirano ranftalazinona como inibidores de pde4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O E 7O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |