ZA200101565B - Composition and methods for treatment of mitochondrial disease. - Google Patents
Composition and methods for treatment of mitochondrial disease. Download PDFInfo
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- ZA200101565B ZA200101565B ZA200101565A ZA200101565A ZA200101565B ZA 200101565 B ZA200101565 B ZA 200101565B ZA 200101565 A ZA200101565 A ZA 200101565A ZA 200101565 A ZA200101565 A ZA 200101565A ZA 200101565 B ZA200101565 B ZA 200101565B
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- South Africa
- Prior art keywords
- mitochondrial
- respiratory chain
- compound
- dysfunction
- disease
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Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776838B1 (en) * | 1987-10-28 | 2010-08-17 | Wellstat Therapeutics Corporation | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| US20020006913A1 (en) * | 1997-11-04 | 2002-01-17 | Von Borstel Reid W. | Antimutagenic compositions for treatment and prevention of photodamage to skin |
| US8143234B2 (en) * | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
| US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
| US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| US20060069061A1 (en) * | 1998-07-31 | 2006-03-30 | Dick Wurtman | Compositions containing uridine and choline, and methods utilizing same |
| US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
| US20070004670A1 (en) * | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
| WO2000006174A1 (en) * | 1998-07-31 | 2000-02-10 | Massachusetts Institute Of Technology | Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases |
| US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
| US7807654B2 (en) * | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| KR100879559B1 (ko) * | 1999-02-23 | 2009-01-22 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 미토콘드리아 장애의 치료 또는 예방용 제약조성물 |
| US6616942B1 (en) | 1999-03-29 | 2003-09-09 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
| US6878514B1 (en) * | 1999-03-30 | 2005-04-12 | Purdue Research Foundation | Methods for identifying agents that inhibit serum aging factors and uses and compositions thereof |
| WO2001021208A1 (en) | 1999-09-23 | 2001-03-29 | Juvenon Corporation | Nutritional supplement for increased energy and stamina |
| US6562869B1 (en) | 1999-09-23 | 2003-05-13 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
| ES2425114T3 (es) | 2000-03-16 | 2013-10-11 | The Mclean Hospital Corporation | CDP-colina y uridina para el tratamiento del abuso del acohol |
| US6727231B1 (en) | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
| US7666445B2 (en) * | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
| AUPR177300A0 (en) * | 2000-11-29 | 2000-12-21 | Centre For Molecular Biology And Medicine | Therapeutic methods |
| US7118873B2 (en) | 2000-12-12 | 2006-10-10 | The University Of Connecticut | Polynucleotides encoding cellular transporters and methods of use thereof |
| DE10110355A1 (de) | 2001-03-03 | 2002-09-12 | Ulrich Walker | Bekämpfung von Nebenwirkungen |
| US7501429B2 (en) * | 2001-04-11 | 2009-03-10 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
| WO2002083651A2 (en) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
| EP1397136A1 (en) * | 2001-05-25 | 2004-03-17 | Queen's University At Kingston | Heterocyclic beta-aminoacids and their use as anti-epileptogenic agents |
| KR100740079B1 (ko) * | 2001-09-05 | 2007-07-18 | 야마사 쇼유 가부시키가이샤 | 당뇨병성 신경 장해용 의약 조성물 |
| NL1019368C2 (nl) * | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
| WO2003047558A2 (en) * | 2001-12-03 | 2003-06-12 | Genset S.A. | Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors |
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| KR20050044890A (ko) * | 2002-07-11 | 2005-05-13 | 야마사 쇼유 가부시키가이샤 | 약제 유발성 신경장해용 의약 조성물 |
| EP2491943B1 (en) * | 2003-02-04 | 2018-10-10 | Cornell Research Foundation, Inc. | Methods for preventing mitochondrial permeability transition |
| CN100536909C (zh) * | 2003-02-04 | 2009-09-09 | 科内尔研究基金会 | 用于防止线粒体通透性改变的方法 |
| US20080089877A1 (en) * | 2003-08-14 | 2008-04-17 | Udell Ronald G | Super Absorption Coenzyme Q10 |
| US7470798B2 (en) * | 2003-09-19 | 2008-12-30 | Edison Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| US8124072B2 (en) | 2003-09-29 | 2012-02-28 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| US8105583B2 (en) | 2003-09-29 | 2012-01-31 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| US7169385B2 (en) * | 2003-09-29 | 2007-01-30 | Ronald G. Udell | Solubilized CoQ-10 and carnitine |
| CA2547086A1 (en) * | 2003-11-25 | 2005-06-09 | University Of Rochester | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof |
| US20060160748A1 (en) * | 2003-11-25 | 2006-07-20 | Shey-Shing Sheu | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof |
| US8329203B2 (en) * | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| EP1711124A4 (en) * | 2004-01-12 | 2011-06-01 | Univ Pennsylvania | LONG-TERM RELEASE PREPARATIONS AND METHODS OF USE THEREOF |
| US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| RU2376028C2 (ru) | 2004-01-23 | 2009-12-20 | Корнелл Рисеч Фаундейшн, Инк. | Способ уменьшения окислительного повреждения (варианты) |
| WO2005077040A2 (en) * | 2004-02-11 | 2005-08-25 | Rensselaer Polytechnic Institute | Compositions and methods for treating amyotrophic lateral sclerosis (als) |
| JP5523669B2 (ja) * | 2004-05-13 | 2014-06-18 | マサチューセッツ インスティテュート オブ テクノロジー | ドーパミン放出に対するウリジンの効果 |
| WO2005122767A1 (en) | 2004-06-10 | 2005-12-29 | Mclean Hospital Corporation | Pyrimidines, such as uridine, in treatments for patients with bipolar disorder |
| KR100675225B1 (ko) * | 2004-06-28 | 2007-01-26 | 대림산업 주식회사 | 차음성능 및 단열성능 향상을 위한 경량벽체 시스템 및 그설치방법 |
| JP2008508300A (ja) * | 2004-07-28 | 2008-03-21 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 抗癌剤としての３−ブロモ−２−オキソプロピオン酸プロピルおよび誘導体 |
| EP1784199A4 (en) | 2004-08-11 | 2010-06-23 | Mclean Hospital Corp | COMPOUNDS FOR TREATING MARIHUANA DEPENDENCE, DEDUCTION AND CONSUMPTION |
| CN102600199A (zh) * | 2004-09-15 | 2012-07-25 | 麻省理工学院 | 含有尿苷的组合物及使用其的方法 |
| US8034823B2 (en) * | 2005-02-22 | 2011-10-11 | Savvipharm Inc | Method of increasing drug oral bioavailability and compositions of less toxic orotate salts |
| US8415388B2 (en) * | 2005-02-22 | 2013-04-09 | Savvipharm Inc. | Pharmaceutical compositions containing paclitaxel orotate |
| WO2006102439A2 (en) * | 2005-03-23 | 2006-09-28 | Florida Atlantic University | Treatment or prevention of cancer and precancerous disorders |
| US8357720B2 (en) * | 2005-03-23 | 2013-01-22 | Florida Atlantic University | Treatment or prevention of cancer and precancerous disorders |
| WO2006121868A2 (en) * | 2005-05-06 | 2006-11-16 | University Of Kentucky Research Foundation | Nanotubes as mitochondrial uncouplers |
| JP5566603B2 (ja) * | 2005-05-23 | 2014-08-06 | マサチューセッツ インスティテュート オブ テクノロジー | Ｐｕｆａを含有する組成物及びそれを使用した方法 |
| MX359292B (es) * | 2005-06-01 | 2018-09-24 | Bioelectron Tech Corp | Sustancias terapeuticas activas redox para el tratamiento de enfermedades mitocondriales y otras condiciones y modulacion de biomarcadores de energia. |
| US20090298782A1 (en) * | 2005-12-20 | 2009-12-03 | University Of Rochester | Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria and Use Thereof |
| CA2635280C (en) | 2006-02-22 | 2017-12-12 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| US20070197649A1 (en) * | 2006-02-22 | 2007-08-23 | Arnold Munnich | Use of deferiprone and methods to treat and/or prevent Friedreich Ataxia resulting from intracellular mishandling of iron |
| KR100801057B1 (ko) * | 2006-07-18 | 2008-02-04 | 삼성전자주식회사 | 컬러 보정 블럭을 구비하는 ｃｍｏｓ 이미지 센서 및 그이미지 센싱 방법 |
| US8343541B2 (en) | 2007-03-15 | 2013-01-01 | Soft Gel Technologies, Inc. | Ubiquinol and alpha lipoic acid compositions |
| MX2009010407A (es) | 2007-03-28 | 2009-12-01 | Apotex Technologies Inc | Derivados fluorados de deferiprona. |
| WO2009059306A1 (en) * | 2007-11-02 | 2009-05-07 | Massachusetts Institute Of Technology | Uridine dietary supplementation compliance methods and use thereof |
| EP3409793A1 (en) * | 2007-11-09 | 2018-12-05 | MDNA Life Sciences Inc. | Mitochondrial dna deletion between about residues 12317-16254 for use in the detection of cancer |
| BRPI0819795B8 (pt) * | 2007-11-28 | 2021-05-25 | Astellas Pharma Inc | compostos de indano fundidos e seus usos no tratamento de doenças relacionadas ao receptor nmda, bem como composição farmacêutica compreendendo os mesmos |
| EP2609812B1 (en) * | 2007-12-20 | 2018-08-29 | N.V. Nutricia | Liquid nucleotides/nucleosides-containing product |
| CN102014904B (zh) * | 2008-04-25 | 2013-02-06 | 阿普泰克斯科技公司 | 具有适口味道的去铁酮液体配制品 |
| LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
| JP5426918B2 (ja) * | 2009-04-20 | 2014-02-26 | 株式会社 伊藤園 | ウリジンを含有する抗疲労剤又は体力向上剤 |
| US20120122969A1 (en) | 2009-06-25 | 2012-05-17 | Ampere Life Sciences, Inc. | Treatment of pervasive developmental disorders with tocotrienols or tocotrienol enriched extracts |
| WO2011000104A1 (en) | 2009-07-03 | 2011-01-06 | Apotex Technologies Inc. | Fluorinated derivatives of 3-hydroxypyridin-4-ones |
| US8776268B2 (en) * | 2009-12-04 | 2014-07-15 | Harpswell Harmony LLC | Hand covering(s) with dispenser and/or receptacle pocket |
| WO2012133896A1 (ja) | 2011-03-31 | 2012-10-04 | YANO Takamitsu | ポリアミド化合物及びミトコンドリア遺伝子疾患治療用医薬組成物 |
| WO2013035101A1 (en) | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
| JP2014527969A (ja) | 2011-09-19 | 2014-10-23 | ジェンシア コーポレイション | 改変クレアチン化合物 |
| CA2908348C (en) | 2013-05-24 | 2021-05-25 | Nestec S.A. | Treatment or prevention of autism disorders using menthol, linalool and/or icilin |
| KR101636946B1 (ko) * | 2013-07-29 | 2016-07-06 | 한국생명공학연구원 | 오로트산을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물 |
| WO2016196012A1 (en) | 2015-05-29 | 2016-12-08 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| CA2991271C (en) * | 2015-06-05 | 2023-10-17 | Fundacio Hospital Universitari Vall D'hebron - Institut De Recerca | Treatment of mitochondrial diseases |
| WO2017062992A1 (en) * | 2015-10-08 | 2017-04-13 | Retrotope, Inc. | Improving quality of mitochondrial dna measurements for use in assessing mitochondrial dysfunctions |
| US20180318381A1 (en) * | 2015-10-23 | 2018-11-08 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Methods of Treatment of Rhabdomyolysis |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| WO2017123823A1 (en) * | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Alkyl-, acyl-, urea-, and aza-uracil sulfide:quinone oxidoreductase inhibitors |
| AU2017312116A1 (en) | 2016-08-17 | 2019-03-07 | Solstice Biologics, Ltd. | Polynucleotide constructs |
| US11938117B2 (en) * | 2016-09-01 | 2024-03-26 | Nutrition21, LLC | Magnesium biotinate compositions and methods of use |
| CN107412731B (zh) * | 2017-05-17 | 2020-06-05 | 广州弘宝元生物科技有限公司 | Ul43蛋白在制备预防和治疗线粒体功能障碍的药物中的应用 |
| EP3645546A4 (en) | 2017-06-30 | 2021-12-01 | Solstice Biologics, Ltd. | CHIRAL PHOSPHORAMIDITIS AUXILIARIES AND THEIR METHODS OF USE |
| WO2019034723A1 (en) * | 2017-08-16 | 2019-02-21 | Lgv1 S.R.L. | VTFT ISOFORM OF BPIFB4 PROTEIN INTENDED FOR USE IN NEURONAL DISEASES AND INJURIES |
| BR112020013342A2 (pt) * | 2018-02-01 | 2020-12-01 | Wellstat Therapeutics Corporation | composições e dispositivos para fornecimento sistêmico de uridina |
| WO2020006118A1 (en) * | 2018-06-26 | 2020-01-02 | Ribonova Inc. | Systems and methods for computing measurements for mitochondrial diseases |
| US20200022432A1 (en) * | 2018-07-21 | 2020-01-23 | Sheryl K. Bailey | Mobile Pocket Glove and Non-gender Hand Wallet |
| US11951135B2 (en) | 2018-07-22 | 2024-04-09 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of muscle diseases |
| CA3106188A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria |
| CA3130389C (en) * | 2019-04-18 | 2024-01-16 | Simo Rasi | Composition for use in prevention or reduction of oxidative stress and neurodegenerative diseases |
| EP3970713A1 (en) | 2020-09-16 | 2022-03-23 | GV Squared S.r.l. | Pharmaceutical composition comprising uridine and pyruvate for regulating the profileration, activity and survival of immune cells |
| EP4225322A1 (en) * | 2020-10-09 | 2023-08-16 | Adarx Pharmaceuticals, Inc. | N-acetylgalactosamine(galnac)-derived compounds and oligonucleotides |
| US20240115592A1 (en) * | 2020-12-28 | 2024-04-11 | Yamasa Corporation | PGC-1alpha EXPRESSION PROMOTING AGENT, MUSCLE-BUILDING AGENT AND MITOCHONDRIA ACTIVATING AGENT |
| US11491130B2 (en) | 2021-02-05 | 2022-11-08 | Retrotope, Inc. | Methods of treating amyotrophic lateral sclerosis |
| US11510889B2 (en) | 2021-02-05 | 2022-11-29 | Retrotope, Inc. | Methods for inhibiting the progression of neurodegenerative diseases |
| CN113413394B (zh) * | 2021-07-27 | 2022-07-01 | 陈玉松 | 5’-单磷酸核苷酸及其混合物在制备改善线粒体功能药物或食品中的应用 |
| CN115737666B (zh) * | 2022-11-24 | 2024-03-26 | 暨南大学 | 尿苷二磷酸葡萄糖在制备延缓衰老产品中的应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB817877A (en) * | 1957-01-30 | 1959-08-06 | Ici Ltd | New pyrimidine derivatives |
| GB1297398A (ko) | 1969-08-06 | 1972-11-22 | ||
| US4600573A (en) * | 1983-01-17 | 1986-07-15 | Research Corporation | Compositions and method for alleviating the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea |
| JPS60126221A (ja) | 1983-12-14 | 1985-07-05 | Toyama Chem Co Ltd | 抗腫瘍組成物 |
| JPS60174797A (ja) | 1984-02-21 | 1985-09-09 | Funai Corp | Ν−アロイルチミジン誘導体ならびに抗腫瘍活性物質の毒性低下剤 |
| WO1986003678A1 (en) * | 1984-12-20 | 1986-07-03 | Memorial Hospital For Cancer And Allied Diseases | Composition and method for treatment of tumors with udpg |
| IT1188178B (it) * | 1985-07-05 | 1988-01-07 | Bioresearch Spa | Sali della citidin-difospocolina particolarmente idonei per uso orale |
| JP2894610B2 (ja) * | 1987-10-28 | 1999-05-24 | プロ−ニューロン，インコーポレーテッド | アシル化ウリジンおよびシチジンならびにその使用 |
| US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| US5736531A (en) | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
| US5691320A (en) | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
| US5470838A (en) * | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
| IT1219667B (it) | 1988-06-21 | 1990-05-24 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
| IT1241984B (it) * | 1990-06-13 | 1994-02-02 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico delle complicazioni periferiche del diabete |
| US5658956A (en) * | 1991-03-01 | 1997-08-19 | Warner-Lambert Company | Bioadhesive-wound healing compositions and methods for preparing and using same |
| IT1248528B (it) * | 1991-06-21 | 1995-01-19 | Pierrel Spa | Derivati di eteri e tioeteri (etero) aromatici aventi attivita` antiiperlipidemica, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
| AU666372B2 (en) * | 1992-05-28 | 1996-02-08 | Centre For Molecular Biology And Medicine | Therapeutic compositions |
| WO1994026761A1 (en) | 1993-05-14 | 1994-11-24 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| MX9700109A (es) * | 1994-07-01 | 1997-04-30 | Pro Neuron Inc | Precursores nucleotidos de pirimidina para el tratamiento de inflamaciones sistemicas y hepatitis inflamatoria. |
| CN1156409A (zh) * | 1994-07-01 | 1997-08-06 | 普罗神经细胞有限公司 | 用于治疗全身性炎症和炎性肝炎的嘧啶核苷酸前体 |
| EP2327404A1 (en) | 1994-11-08 | 2011-06-01 | Avicena Group, Inc. | Use of creatine or creatine analogs for the treatment of diseases of the nervous system |
| IT1290781B1 (it) * | 1996-05-28 | 1998-12-10 | Polifarma Spa | Agente attivo terapeutico per il trattamento di malattie degenerative neuronali. |
| US5906996A (en) | 1996-08-21 | 1999-05-25 | Murphy; Michael A. | Tetramine treatment of neurological disorders |
| WO2000006174A1 (en) * | 1998-07-31 | 2000-02-10 | Massachusetts Institute Of Technology | Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases |
| US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US20040224920A1 (en) | 1999-02-23 | 2004-11-11 | The Regents Of The University Of California | Methods of treatment of mitochondrial disorders |
| KR100879559B1 (ko) | 1999-02-23 | 2009-01-22 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 미토콘드리아 장애의 치료 또는 예방용 제약조성물 |
| ITMI20020809A1 (it) * | 2002-04-17 | 2003-10-17 | Univ Degli Studi Milano | Metodo per la selezione di composti utili nel trattamento della coreadi huntington |
| JP4243830B2 (ja) | 2002-10-18 | 2009-03-25 | セイコーエプソン株式会社 | 定着装置、およびそれを用いた画像形成装置 |
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