ZA200100719B - Estradiol-containing patch for transdermal administration of hormones. - Google Patents
Estradiol-containing patch for transdermal administration of hormones. Download PDFInfo
- Publication number
- ZA200100719B ZA200100719B ZA200100719A ZA200100719A ZA200100719B ZA 200100719 B ZA200100719 B ZA 200100719B ZA 200100719 A ZA200100719 A ZA 200100719A ZA 200100719 A ZA200100719 A ZA 200100719A ZA 200100719 B ZA200100719 B ZA 200100719B
- Authority
- ZA
- South Africa
- Prior art keywords
- active substance
- containing patch
- pressure
- patch according
- reservoir
- Prior art date
Links
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title claims description 17
- 229960005309 estradiol Drugs 0.000 title claims description 16
- 229930182833 estradiol Natural products 0.000 title claims description 16
- 229940088597 hormone Drugs 0.000 title description 2
- 239000005556 hormone Substances 0.000 title description 2
- 239000013543 active substance Substances 0.000 claims description 41
- 239000010410 layer Substances 0.000 claims description 17
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 14
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 12
- 239000000853 adhesive Substances 0.000 claims description 10
- 230000001070 adhesive effect Effects 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 9
- 239000000583 progesterone congener Substances 0.000 claims description 9
- 239000004166 Lanolin Substances 0.000 claims description 6
- 235000019388 lanolin Nutrition 0.000 claims description 6
- 239000011787 zinc oxide Substances 0.000 claims description 6
- 239000011241 protective layer Substances 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 239000003223 protective agent Substances 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 238000013270 controlled release Methods 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000004831 Hot glue Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000004014 plasticizer Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- ZVVGLAMWAQMPDR-WVEWYJOQSA-N (8r,9s,13s,14s,17s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol;hydrate Chemical compound O.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 ZVVGLAMWAQMPDR-WVEWYJOQSA-N 0.000 description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 2
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002313 adhesive film Substances 0.000 description 2
- 229960003851 estradiol hemihydrate Drugs 0.000 description 2
- 229960001652 norethindrone acetate Drugs 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 239000004840 adhesive resin Substances 0.000 description 1
- 229920006223 adhesive resin Polymers 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/651—The particulate/core comprising inorganic material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19834007A DE19834007C1 (de) | 1998-07-29 | 1998-07-29 | Estradiolhaltiges Pflaster zur transdermalen Applikation von Hormonen und seine Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200100719B true ZA200100719B (en) | 2002-06-14 |
Family
ID=7875613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200100719A ZA200100719B (en) | 1998-07-29 | 2001-01-25 | Estradiol-containing patch for transdermal administration of hormones. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6531149B1 (pt) |
| EP (1) | EP1100477B1 (pt) |
| JP (1) | JP2002521427A (pt) |
| KR (1) | KR100559089B1 (pt) |
| CN (1) | CN1172661C (pt) |
| AR (1) | AR021459A1 (pt) |
| AT (1) | ATE264097T1 (pt) |
| AU (1) | AU758107B2 (pt) |
| BR (1) | BR9912687A (pt) |
| CA (1) | CA2338859C (pt) |
| DE (2) | DE19834007C1 (pt) |
| ES (1) | ES2220093T3 (pt) |
| IL (2) | IL141033A0 (pt) |
| PL (1) | PL194102B1 (pt) |
| TR (1) | TR200100289T2 (pt) |
| TW (1) | TW542726B (pt) |
| WO (1) | WO2000006131A1 (pt) |
| ZA (1) | ZA200100719B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10304988A1 (de) * | 2003-02-07 | 2004-09-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit verbessertem Hautklebeverhalten |
| JP2006525030A (ja) * | 2003-05-07 | 2006-11-09 | セダーズ−シナイ メディカル センター | 細胞内エストラジオール結合タンパク質、このタンパク質をコードするポリヌクレオチドおよびこのタンパク質を過剰発現する細胞 |
| US7251128B2 (en) * | 2004-09-30 | 2007-07-31 | Intel Corporation | Adjustable portable computer |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| PT2782584T (pt) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Preparações e terapias de substituição para hormonoterapias naturais combinadas |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| MX2016014281A (es) | 2014-05-22 | 2017-02-22 | Therapeuticsmd Inc | Formulaciones y terapias de reemplazo de combinación de hormonas naturales. |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE251567C (pt) | ||||
| NL6902314A (pt) | 1969-02-13 | 1970-08-17 | ||
| US3637224A (en) | 1969-02-27 | 1972-01-25 | Fedders Corp | Annular sealing ring |
| US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| CA1248450A (en) * | 1984-04-05 | 1989-01-10 | Kazuo Kigasawa | Soft patch |
| US4624665A (en) | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
| US4720489A (en) * | 1984-10-15 | 1988-01-19 | Douglas Shander | Hair growth modification with ornithine decarboxylase inhibitors |
| EP0186019B1 (de) * | 1984-12-22 | 1993-10-06 | Schwarz Pharma Ag | Wirkstoffpflaster |
| US4883669A (en) | 1985-02-25 | 1989-11-28 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration |
| DD251567A1 (de) * | 1986-07-30 | 1987-11-18 | Jenapharm Veb | Verfahren zur herstellung gefaerbter, selbstklebender loesungsmittelhaltiger polymermischungen |
| CN1021196C (zh) | 1986-12-29 | 1993-06-16 | 新泽西州州立大学(鲁杰斯) | 透皮雌激素/孕激素药剂单元、系统及方法 |
| CH674618A5 (pt) | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
| DE3743946A1 (de) | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung |
| US4906475A (en) | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
| JPH02180835A (ja) * | 1988-12-29 | 1990-07-13 | Lion Corp | 外用製剤 |
| EP0409383B1 (en) * | 1989-07-21 | 1994-04-06 | Izhak Blank | Estradiol compositions and methods for topical applications |
| AU644815B2 (en) * | 1989-09-08 | 1993-12-23 | Ortho-Mcneil Pharmaceutical, Inc. | Solid matrix system for transdermal drug delivery |
| JP3273430B2 (ja) * | 1989-12-28 | 2002-04-08 | 日東電工株式会社 | エストロゲン含有ゲル製剤 |
| DE4115849A1 (de) * | 1991-05-15 | 1992-11-19 | Lohmann Therapie Syst Lts | Penetrationsfoerdernde substanz |
| JPH04342532A (ja) * | 1991-05-21 | 1992-11-30 | Sekisui Chem Co Ltd | 経皮吸収貼付剤 |
| JP3086288B2 (ja) * | 1991-07-23 | 2000-09-11 | 扶桑薬品工業株式会社 | 経皮吸収製剤 |
| JPH05148135A (ja) * | 1991-11-29 | 1993-06-15 | L T T Kenkyusho:Kk | 貼付剤用物理的吸収促進剤及びそれを含む貼付剤 |
| DE4230588C1 (de) * | 1992-09-12 | 1993-10-07 | Lohmann Therapie Syst Lts | Dexpanthenol-haltiges Pflaster zur transdermalen Applikation von Steroidhormonen und Verfahren zu seiner Herstellung |
| JP2569396B2 (ja) * | 1992-12-04 | 1997-01-08 | 株式会社太平洋 | 経皮投与型薬物用貼付剤 |
| JP3197102B2 (ja) * | 1993-03-29 | 2001-08-13 | 積水化学工業株式会社 | 経皮吸収製剤及びその製造方法 |
| JP3305101B2 (ja) * | 1994-03-29 | 2002-07-22 | 積水化学工業株式会社 | 経皮吸収製剤 |
| DE4416927C1 (de) * | 1994-05-13 | 1995-08-31 | Lohmann Therapie Syst Lts | Vorrichtung zur Abgabe von Wirkstoffen aus Haftschmelzklebern, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JPH0827003A (ja) * | 1994-07-22 | 1996-01-30 | Sekisui Chem Co Ltd | 経皮吸収製剤 |
| WO1996015776A1 (fr) * | 1994-11-18 | 1996-05-30 | Hisamitsu Pharmaceutical Co., Inc. | Timbre absorbable par voie percutanee |
| EP0746311B1 (en) | 1994-12-24 | 2001-07-11 | Pacific Corporation | Medicinal patches for percutaneous administration |
| CA2222133C (en) * | 1995-06-07 | 2002-12-24 | Cygnus, Inc. | Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen |
| US5783208A (en) * | 1996-07-19 | 1998-07-21 | Theratech, Inc. | Transdermal drug delivery matrix for coadministering estradiol and another steroid |
| US5948433A (en) * | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
-
1998
- 1998-07-29 DE DE19834007A patent/DE19834007C1/de not_active Expired - Fee Related
-
1999
- 1999-07-16 JP JP2000561986A patent/JP2002521427A/ja active Pending
- 1999-07-16 DE DE59909189T patent/DE59909189D1/de not_active Expired - Lifetime
- 1999-07-16 KR KR1020017001313A patent/KR100559089B1/ko not_active IP Right Cessation
- 1999-07-16 WO PCT/EP1999/005085 patent/WO2000006131A1/de active IP Right Grant
- 1999-07-16 EP EP99936555A patent/EP1100477B1/de not_active Expired - Lifetime
- 1999-07-16 CA CA002338859A patent/CA2338859C/en not_active Expired - Fee Related
- 1999-07-16 IL IL14103399A patent/IL141033A0/xx unknown
- 1999-07-16 PL PL99345695A patent/PL194102B1/pl not_active IP Right Cessation
- 1999-07-16 TR TR2001/00289T patent/TR200100289T2/xx unknown
- 1999-07-16 AU AU51607/99A patent/AU758107B2/en not_active Ceased
- 1999-07-16 AT AT99936555T patent/ATE264097T1/de not_active IP Right Cessation
- 1999-07-16 US US09/744,711 patent/US6531149B1/en not_active Expired - Fee Related
- 1999-07-16 CN CNB998088528A patent/CN1172661C/zh not_active Expired - Fee Related
- 1999-07-16 ES ES99936555T patent/ES2220093T3/es not_active Expired - Lifetime
- 1999-07-16 BR BR9912687-7A patent/BR9912687A/pt not_active IP Right Cessation
- 1999-07-22 TW TW088112440A patent/TW542726B/zh not_active IP Right Cessation
- 1999-07-28 AR ARP990103732A patent/AR021459A1/es active IP Right Grant
-
2001
- 2001-01-23 IL IL141033A patent/IL141033A/en not_active IP Right Cessation
- 2001-01-25 ZA ZA200100719A patent/ZA200100719B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59909189D1 (de) | 2004-05-19 |
| JP2002521427A (ja) | 2002-07-16 |
| AU5160799A (en) | 2000-02-21 |
| CA2338859C (en) | 2007-09-18 |
| CN1310614A (zh) | 2001-08-29 |
| KR100559089B1 (ko) | 2006-03-13 |
| KR20010079571A (ko) | 2001-08-22 |
| WO2000006131A1 (de) | 2000-02-10 |
| DE19834007C1 (de) | 2000-02-24 |
| PL194102B1 (pl) | 2007-04-30 |
| PL345695A1 (en) | 2002-01-02 |
| EP1100477B1 (de) | 2004-04-14 |
| IL141033A0 (en) | 2002-02-10 |
| AR021459A1 (es) | 2002-07-24 |
| CN1172661C (zh) | 2004-10-27 |
| EP1100477A1 (de) | 2001-05-23 |
| US6531149B1 (en) | 2003-03-11 |
| ATE264097T1 (de) | 2004-04-15 |
| AU758107B2 (en) | 2003-03-13 |
| TR200100289T2 (tr) | 2001-07-23 |
| TW542726B (en) | 2003-07-21 |
| BR9912687A (pt) | 2001-06-05 |
| IL141033A (en) | 2009-06-15 |
| CA2338859A1 (en) | 2000-02-10 |
| ES2220093T3 (es) | 2004-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2338859C (en) | Estradiol-containing patch for transdermal administration of hormones | |
| FI119358B (fi) | Estradiolipitoinen laastari | |
| US6143319A (en) | Transdermal therapeutic system containing estradiol | |
| CA2465395A1 (en) | Transdermal therapeutic systems containing steroid hormones and containing propylene glycol monocaprylate | |
| JP2002510315A (ja) | レボノルゲストレルを投与するための経皮吸収治療システム（ｔｔｓ） | |
| SK32795A3 (en) | Dexpanthenol containing plaster for the transdermal application of steroid hormones | |
| AU762589B2 (en) | Estradiol-containing patch for transdermal administration of hormones | |
| MXPA01001042A (en) | Estradiol-containing patch for transdermal administration of hormones | |
| MXPA01001043A (en) | Estradiol-containing patch for transdermal administration of hormones | |
| MXPA97005291A (en) | Patch that contains estrad |