ZA200100279B - Polycyclic thiazolidin-2-ylidene amines, method for the production and use thereof as medicaments. - Google Patents
Polycyclic thiazolidin-2-ylidene amines, method for the production and use thereof as medicaments. Download PDFInfo
- Publication number
- ZA200100279B ZA200100279B ZA200100279A ZA200100279A ZA200100279B ZA 200100279 B ZA200100279 B ZA 200100279B ZA 200100279 A ZA200100279 A ZA 200100279A ZA 200100279 A ZA200100279 A ZA 200100279A ZA 200100279 B ZA200100279 B ZA 200100279B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- phenyl
- pyridyl
- substituted
- thienyl
- Prior art date
Links
- -1 Polycyclic thiazolidin-2-ylidene amines Chemical class 0.000 title claims description 57
- 239000003814 drug Substances 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 213
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 179
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 151
- 229910052801 chlorine Inorganic materials 0.000 claims description 117
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 114
- 125000004076 pyridyl group Chemical group 0.000 claims description 111
- 125000001544 thienyl group Chemical group 0.000 claims description 88
- 229910052739 hydrogen Inorganic materials 0.000 claims description 80
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 78
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 66
- 125000002541 furyl group Chemical group 0.000 claims description 64
- 229910052794 bromium Inorganic materials 0.000 claims description 61
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 57
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 50
- 239000001257 hydrogen Substances 0.000 claims description 50
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 46
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 46
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 40
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 34
- 229910052740 iodine Inorganic materials 0.000 claims description 31
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 24
- 239000011737 fluorine Substances 0.000 claims description 24
- 125000001506 1,2,3-triazol-5-yl group Chemical group [H]N1N=NC([H])=C1[*] 0.000 claims description 23
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 23
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 23
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 23
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 23
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 23
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 23
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 23
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 23
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 23
- 125000001624 naphthyl group Chemical group 0.000 claims description 23
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 23
- 125000001425 triazolyl group Chemical group 0.000 claims description 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 22
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims description 22
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 20
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 18
- 235000010290 biphenyl Nutrition 0.000 claims description 17
- 239000004305 biphenyl Substances 0.000 claims description 17
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 12
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000304 alkynyl group Chemical group 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001539 anorectic effect Effects 0.000 description 3
- 229910014585 C2-Ce Inorganic materials 0.000 description 1
- 150000003548 thiazolidines Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19831878A DE19831878C2 (de) | 1998-07-17 | 1998-07-17 | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200100279B true ZA200100279B (en) | 2001-08-07 |
Family
ID=7874197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200100279A ZA200100279B (en) | 1998-07-17 | 2001-01-10 | Polycyclic thiazolidin-2-ylidene amines, method for the production and use thereof as medicaments. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6159996A (ja) |
| EP (1) | EP1098891B1 (ja) |
| JP (1) | JP3541808B2 (ja) |
| KR (1) | KR20010083118A (ja) |
| CN (1) | CN1144797C (ja) |
| AR (1) | AR019925A1 (ja) |
| AT (1) | ATE301645T1 (ja) |
| AU (1) | AU767151B2 (ja) |
| BR (1) | BR9912151A (ja) |
| CA (1) | CA2337838A1 (ja) |
| CL (1) | CL2004000219A1 (ja) |
| DE (2) | DE19831878C2 (ja) |
| DK (1) | DK1098891T3 (ja) |
| ES (1) | ES2246089T3 (ja) |
| HK (1) | HK1038560A1 (ja) |
| HU (1) | HUP0104942A3 (ja) |
| ID (1) | ID26985A (ja) |
| IL (1) | IL140767A (ja) |
| NO (1) | NO318790B1 (ja) |
| NZ (1) | NZ509395A (ja) |
| PL (1) | PL345619A1 (ja) |
| PT (1) | PT1098891E (ja) |
| RU (1) | RU2236405C2 (ja) |
| TR (1) | TR200100125T2 (ja) |
| WO (1) | WO2000004006A1 (ja) |
| ZA (1) | ZA200100279B (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19908537A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE19908538A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| DE19908533A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| WO2001032638A1 (de) | 1999-11-05 | 2001-05-10 | Aventis Pharma Deutschland Gmbh | Indeno-, naphtho- und benzocyclohepta-dihydrothiazol derivate, deren herstellung und deren verwendung als anorektische arzneimittel |
| BR0108631A (pt) * | 2000-02-26 | 2002-12-03 | Aventis Pharma Gmbh | Derivados de 8,8a-dihidro-indeno[1,2-d] tiazol, que na posição 2 portam um substituinte com uma estrutura sulfonamida ou estrutura sulfona; processos para a sua preparação e seu emprego como medicamento |
| DE10142722A1 (de) | 2001-08-31 | 2003-03-27 | Aventis Pharma Gmbh | C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10142665B4 (de) * | 2001-08-31 | 2004-05-06 | Aventis Pharma Deutschland Gmbh | C2-Disubstituierte Indan-1-one und ihre Derivate |
| US7977532B2 (en) * | 2002-09-05 | 2011-07-12 | The Procter & Gamble Company | Tampon with clean appearance post use |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| EP1767565B1 (en) * | 2004-07-09 | 2015-04-01 | Nissan Chemical Industries, Ltd. | Process for purification of oligoanilines and oligoanilines |
| WO2007054257A2 (en) * | 2005-11-08 | 2007-05-18 | Laboratorios Del Dr. Esteve, S.A. | Indene derivatives, their preparation and use as medicaments |
| KR101626996B1 (ko) * | 2008-03-31 | 2016-06-02 | 제넨테크, 인크. | 벤조피란 및 벤족세핀 ｐｉ３ｋ 저해제 화합물 및 이의 사용 방법 |
| PL2686302T3 (pl) | 2011-03-16 | 2017-01-31 | Mitsubishi Tanabe Pharma Corporation | Związki sulfonamidowe mające działanie antagonistyczne dla TRPMS |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507868A (en) * | 1968-10-21 | 1970-04-21 | Sandoz Ag | Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
-
1998
- 1998-07-17 DE DE19831878A patent/DE19831878C2/de not_active Expired - Fee Related
-
1999
- 1999-07-03 CN CNB998087165A patent/CN1144797C/zh not_active Expired - Fee Related
- 1999-07-03 DE DE59912402T patent/DE59912402D1/de not_active Expired - Lifetime
- 1999-07-03 TR TR2001/00125T patent/TR200100125T2/xx unknown
- 1999-07-03 RU RU2001104480/04A patent/RU2236405C2/ru not_active IP Right Cessation
- 1999-07-03 PL PL99345619A patent/PL345619A1/xx not_active Application Discontinuation
- 1999-07-03 AU AU50308/99A patent/AU767151B2/en not_active Ceased
- 1999-07-03 HU HU0104942A patent/HUP0104942A3/hu unknown
- 1999-07-03 DK DK99934568T patent/DK1098891T3/da active
- 1999-07-03 KR KR1020017000694A patent/KR20010083118A/ko not_active Application Discontinuation
- 1999-07-03 PT PT99934568T patent/PT1098891E/pt unknown
- 1999-07-03 CA CA002337838A patent/CA2337838A1/en not_active Abandoned
- 1999-07-03 BR BR9912151-4A patent/BR9912151A/pt not_active Application Discontinuation
- 1999-07-03 ES ES99934568T patent/ES2246089T3/es not_active Expired - Lifetime
- 1999-07-03 NZ NZ509395A patent/NZ509395A/en unknown
- 1999-07-03 JP JP2000560113A patent/JP3541808B2/ja not_active Expired - Fee Related
- 1999-07-03 AT AT99934568T patent/ATE301645T1/de not_active IP Right Cessation
- 1999-07-03 WO PCT/EP1999/004644 patent/WO2000004006A1/de not_active Application Discontinuation
- 1999-07-03 IL IL14076799A patent/IL140767A/xx not_active IP Right Cessation
- 1999-07-03 ID IDW20010125A patent/ID26985A/id unknown
- 1999-07-03 EP EP99934568A patent/EP1098891B1/de not_active Expired - Lifetime
- 1999-07-12 US US09/351,621 patent/US6159996A/en not_active Expired - Lifetime
- 1999-07-15 AR ARP990103487A patent/AR019925A1/es unknown
-
2001
- 2001-01-10 ZA ZA200100279A patent/ZA200100279B/en unknown
- 2001-01-12 NO NO20010219A patent/NO318790B1/no unknown
- 2001-12-28 HK HK01109163A patent/HK1038560A1/xx not_active IP Right Cessation
-
2004
- 2004-02-06 CL CL200400219A patent/CL2004000219A1/es unknown
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