ZA200007306B - Pyrazinone protease inhibitors. - Google Patents

Pyrazinone protease inhibitors.

Info

Publication number
ZA200007306B
ZA200007306B ZA200007306A ZA200007306A ZA200007306B ZA 200007306 B ZA200007306 B ZA 200007306B ZA 200007306 A ZA200007306 A ZA 200007306A ZA 200007306 A ZA200007306 A ZA 200007306A ZA 200007306 B ZA200007306 B ZA 200007306B
Authority
ZA
South Africa
Prior art keywords
blood
inhibiting
compounds
formation
thrombin
Prior art date
Application number
ZA200007306A
Other languages
English (en)
Inventor
Tianbao Lu
Bruce E Tomczuk
Thomas P Markotan
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of ZA200007306B publication Critical patent/ZA200007306B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
ZA200007306A 1998-06-11 2000-12-08 Pyrazinone protease inhibitors. ZA200007306B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8898998P 1998-06-11 1998-06-11

Publications (1)

Publication Number Publication Date
ZA200007306B true ZA200007306B (en) 2001-06-13

Family

ID=22214697

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200007306A ZA200007306B (en) 1998-06-11 2000-12-08 Pyrazinone protease inhibitors.

Country Status (21)

Country Link
US (2) US6204263B1 (xx)
EP (2) EP1589029B1 (xx)
JP (1) JP4554077B2 (xx)
KR (1) KR100669953B1 (xx)
CN (2) CN1224629C (xx)
AT (2) ATE302794T1 (xx)
AU (1) AU759427B2 (xx)
BR (1) BR9911100A (xx)
CA (1) CA2334679C (xx)
DE (2) DE69926884T2 (xx)
DK (1) DK1086122T3 (xx)
EA (1) EA004884B1 (xx)
ES (2) ES2249012T3 (xx)
HU (1) HUP0103283A3 (xx)
IL (1) IL139867A0 (xx)
NO (1) NO20006300L (xx)
NZ (1) NZ508669A (xx)
PL (1) PL344749A1 (xx)
SI (1) SI1086122T1 (xx)
WO (1) WO1999064446A1 (xx)
ZA (1) ZA200007306B (xx)

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US6686484B2 (en) 2000-04-17 2004-02-03 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
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US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
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US9610359B2 (en) 2009-12-23 2017-04-04 Burnham Institute For Medical Research Methods and compositions related to annexin 1-binding compounds
CA2795289A1 (en) 2010-04-08 2011-10-13 Sanford-Burnham Medical Research Institute Methods and compositions for enhanced delivery of compounds
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US9788539B2 (en) 2011-05-17 2017-10-17 Velico Medical, Inc. Platelet protection solution having beta-galactosidase and sialidase inhibitors
EP2709446A2 (en) 2011-05-17 2014-03-26 Velico Medical, Inc. Platelet storage using a sialidase inhibitor
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CA2887083A1 (en) 2012-10-05 2014-04-10 Velico Medical, Inc. Platelet additive solution having a beta-galactosidase inhibitor
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CN106379607A (zh) * 2016-10-08 2017-02-08 周末 一种瓶身机械印模制药装置
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Also Published As

Publication number Publication date
NO20006300L (no) 2001-02-12
NO20006300D0 (no) 2000-12-11
DK1086122T3 (da) 2006-01-09
KR20010052772A (ko) 2001-06-25
ATE461210T1 (de) 2010-04-15
ATE302794T1 (de) 2005-09-15
EA004884B1 (ru) 2004-08-26
DE69942159D1 (de) 2010-04-29
JP2002517512A (ja) 2002-06-18
SI1086122T1 (sl) 2006-02-28
DE69926884T2 (de) 2006-06-14
DE69926884D1 (de) 2005-09-29
CN1769274A (zh) 2006-05-10
PL344749A1 (en) 2001-11-19
AU4561899A (en) 1999-12-30
CA2334679A1 (en) 1999-12-16
HUP0103283A2 (hu) 2002-04-29
AU759427B2 (en) 2003-04-17
US6514978B2 (en) 2003-02-04
BR9911100A (pt) 2001-02-13
ES2343120T3 (es) 2010-07-23
IL139867A0 (en) 2002-02-10
JP4554077B2 (ja) 2010-09-29
EP1086122B1 (en) 2005-08-24
KR100669953B1 (ko) 2007-01-18
US20010021713A1 (en) 2001-09-13
ES2249012T3 (es) 2006-03-16
EP1086122A1 (en) 2001-03-28
EP1589029B1 (en) 2010-03-17
HUP0103283A3 (en) 2002-05-28
CN1224629C (zh) 2005-10-26
EP1589029A3 (en) 2006-01-18
US6204263B1 (en) 2001-03-20
NZ508669A (en) 2003-06-30
EA200100025A1 (ru) 2001-06-25
WO1999064446A1 (en) 1999-12-16
CA2334679C (en) 2012-10-23
CN1305492A (zh) 2001-07-25
EP1589029A2 (en) 2005-10-26

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