DE69926884D1 - Pyrazine protease inhibitore - Google Patents

Pyrazine protease inhibitore

Info

Publication number
DE69926884D1
DE69926884D1 DE69926884T DE69926884T DE69926884D1 DE 69926884 D1 DE69926884 D1 DE 69926884D1 DE 69926884 T DE69926884 T DE 69926884T DE 69926884 T DE69926884 T DE 69926884T DE 69926884 D1 DE69926884 D1 DE 69926884D1
Authority
DE
Germany
Prior art keywords
blood
inhibiting
compounds
formation
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69926884T
Other languages
English (en)
Other versions
DE69926884T2 (de
Inventor
Tianbao Lu
E Tomczuk
P Markotan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Johnson and Johnson Pharmaceutical Research and Development LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson and Johnson Pharmaceutical Research and Development LLC filed Critical Johnson and Johnson Pharmaceutical Research and Development LLC
Application granted granted Critical
Publication of DE69926884D1 publication Critical patent/DE69926884D1/de
Publication of DE69926884T2 publication Critical patent/DE69926884T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69926884T 1998-06-11 1999-06-11 Pyrazine protease inhibitore Expired - Lifetime DE69926884T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8898998P 1998-06-11 1998-06-11
PCT/US1999/013228 WO1999064446A1 (en) 1998-06-11 1999-06-11 Pyrazinone protease inhibitors

Publications (2)

Publication Number Publication Date
DE69926884D1 true DE69926884D1 (de) 2005-09-29
DE69926884T2 DE69926884T2 (de) 2006-06-14

Family

ID=22214697

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69942159T Expired - Lifetime DE69942159D1 (de) 1998-06-11 1999-06-11 Pyrazine Protease Inhibitore
DE69926884T Expired - Lifetime DE69926884T2 (de) 1998-06-11 1999-06-11 Pyrazine protease inhibitore

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69942159T Expired - Lifetime DE69942159D1 (de) 1998-06-11 1999-06-11 Pyrazine Protease Inhibitore

Country Status (21)

Country Link
US (2) US6204263B1 (de)
EP (2) EP1589029B1 (de)
JP (1) JP4554077B2 (de)
KR (1) KR100669953B1 (de)
CN (2) CN1769274A (de)
AT (2) ATE302794T1 (de)
AU (1) AU759427B2 (de)
BR (1) BR9911100A (de)
CA (1) CA2334679C (de)
DE (2) DE69942159D1 (de)
DK (1) DK1086122T3 (de)
EA (1) EA004884B1 (de)
ES (2) ES2343120T3 (de)
HU (1) HUP0103283A3 (de)
IL (1) IL139867A0 (de)
NO (1) NO20006300L (de)
NZ (1) NZ508669A (de)
PL (1) PL344749A1 (de)
SI (1) SI1086122T1 (de)
WO (1) WO1999064446A1 (de)
ZA (1) ZA200007306B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL340560A1 (en) * 1997-11-26 2001-02-12 Dimensional Pharmaceuticals 3 Heteroaryl aminoguanidines and alkoxyguanidines and their application as protease inhibitors
EP1586565A1 (de) * 1999-05-19 2005-10-19 Pharmacia Corporation Substituierte polycyclische aryl und heteroarylpyrazinone zur selektiven Hemmung von der Blutgerinnungskaskade
SK15872001A3 (sk) * 1999-05-19 2002-10-08 Pharmacia Corporation Polycyklické aryl a heteroaryl pyrazinóny vhodné na selektívnu inhibíciu koagulačnej kaskády
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6660885B2 (en) 2000-03-13 2003-12-09 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
JP2004505013A (ja) 2000-04-05 2004-02-19 ファルマシア・コーポレーション 凝固カスケードを選択的に阻害するのに有用な多環式アリール及びヘテロアリール置換４−ピリドン類
EP1268463B1 (de) 2000-04-05 2005-02-16 Pharmacia Corporation Polyzyclisch aryl und heteroaryl substituierte 4-pyronen verwendbar als selektive hemmung von dem koagulationsprozess
JP2004501077A (ja) 2000-04-17 2004-01-15 ファルマシア・コーポレーション 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換１，４−キノン
MXPA03000512A (es) * 2000-07-17 2003-10-06 Dimensional Pharm Inc Oxiguanidina-pirazinonas ciclicas como inhibidores de proteasas.
MXPA03004458A (es) 2000-11-20 2005-01-25 Pharmacia Corp Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion.
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
WO2003029216A1 (en) 2001-10-03 2003-04-10 Pharmacia Corporation 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
WO2003093242A2 (en) 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
US7262211B2 (en) 2001-12-04 2007-08-28 Dendreon Corporation Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
JP2005213213A (ja) * 2004-01-30 2005-08-11 Fuji Oil Co Ltd 大豆トリプシンインヒビター濃縮物の製造法
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US7468350B2 (en) 2004-06-16 2008-12-23 Pneumrx, Inc. Glue composition for lung volume reduction
WO2006014567A2 (en) 2004-07-08 2006-02-09 Pneumrx, Inc. Pleural effusion treatment device, method and material
US8070678B2 (en) * 2005-10-05 2011-12-06 Gurbel Paul A Detection of restenosis risk in patients receiving a stent by measuring the characteristics of blood clotting including the measurement of maximum thrombin-induced clot strength
US8815804B2 (en) 2006-02-06 2014-08-26 Sanford-Burnham Medical Research Institute Methods and compositions related to targeting tumors and wounds
WO2007137216A2 (en) * 2006-05-22 2007-11-29 Janssen Pharmaceutica, N.V. Gastroretentive sustained release formulations
US20080021044A1 (en) * 2006-05-22 2008-01-24 Patel Mitul N N-[2-[[(diaminomethylene)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxo-1(2h)-pyrazineacetamide
EP2117575A4 (de) 2007-01-03 2013-06-05 Burnham Inst Medical Research Verfahren und zusammensetzungen in verbindung mit gerinnselbindenden verbindungen
JP5244477B2 (ja) * 2008-07-08 2013-07-24 関東化学株式会社 ガドリニウムの影響を回避したカルシウムの測定試薬
JP2013507365A (ja) 2009-10-07 2013-03-04 サンフォード−バーナム メディカル リサーチ インスティテュート 血餅結合脂質化合物に関する方法および組成物
WO2011049964A1 (en) 2009-10-19 2011-04-28 Lab Scientific Group Rna detection and quantitation
CA2784145A1 (en) 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
WO2011079304A1 (en) 2009-12-23 2011-06-30 Sanford-Burnham Medical Research Institute Methods and compositions related to annexin 1-binding compounds
US20110262347A1 (en) 2010-04-08 2011-10-27 The Salk Institute For Biological Studies Methods and compositions for enhanced delivery of compounds
CA2824599C (en) * 2010-12-31 2020-03-10 Corridor Pharmaceuticals, Inc. Arginase inhibitors and methods of use thereof
US9609861B2 (en) 2011-05-17 2017-04-04 Velico Medical Inc. Platelet additive solution having a β-galactosidase inhibitor
US9788539B2 (en) 2011-05-17 2017-10-17 Velico Medical, Inc. Platelet protection solution having beta-galactosidase and sialidase inhibitors
WO2012158983A2 (en) 2011-05-17 2012-11-22 Qiyong Peter Liu Improved platelet storage using a sialidase inhibitor
CA2838188C (en) 2011-06-04 2017-04-18 Rochester General Hospital Research Institute Compositions and methods related to p6 of haemophilus influenzae
WO2014120886A1 (en) 2013-01-30 2014-08-07 Velico Medical, Inc. Platelet additive solution having a self-assembling hydrogel-forming peptide
ES2861180T3 (es) 2013-03-13 2021-10-05 Forma Therapeutics Inc Derivados de 2-hidroxi-1-{4-[(4-fenil)fenil]carbonil}piperazin-1-il}etan-1-ona y compuestos relacionados como inhibidores de sintasa de ácido graso (FASN) para el tratamiento del cáncer
CN106379607A (zh) * 2016-10-08 2017-02-08 周末 一种瓶身机械印模制药装置
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418052A (en) 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
US4980148A (en) 1985-02-06 1990-12-25 Mallinckrodt, Inc. Methods for enhancing magnetic resonance imaging
US5011686A (en) 1987-09-21 1991-04-30 Creative Biomolecules, Inc. Thrombus specific conjugates
ZA897514B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5024829A (en) 1988-11-21 1991-06-18 Centocor, Inc. Method of imaging coronary thrombi
US5122361A (en) 1989-04-17 1992-06-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and imaging agents
EP0604022A1 (de) 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Mehrschichtiges resorbierbares Stent und Verfahren zu dessen Herstellung
US5656600A (en) 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
GB9318637D0 (en) 1993-09-08 1993-10-27 Ferring Res Ltd Enzyme inhibitors
US6087479A (en) 1993-09-17 2000-07-11 Nitromed, Inc. Localized use of nitric oxide-adducts to prevent internal tissue damage
US5466811A (en) 1994-07-18 1995-11-14 Merck & Co., Inc. Dioxolenylmethyl carbamates pro moieties for amine drugs
US5643580A (en) 1994-10-17 1997-07-01 Surface Genesis, Inc. Biocompatible coating, medical device using the same and methods
ATE434423T1 (de) 1994-10-17 2009-07-15 Igaki Iryo Sekkei Kk Medikamentenfreisetzender stent
US6011158A (en) 1994-12-13 2000-01-04 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
NZ298699A (en) * 1994-12-13 2001-03-30 Corvas Int Inc 3-amino-1,2-dihydropyrid-1-yl(and 5-amino-1,6-dihydro-6-oxo(and 5,6-dioxo)pyrimidin-1-yl)-acetyl-argininal derivatives, useful for the treatment of blood coagulation and thrombosis
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
DE19514104C2 (de) 1995-04-13 1997-05-28 Behringwerke Ag Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
CA2233344A1 (en) 1995-09-29 1997-04-03 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
WO1997030708A1 (en) 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors
ATE341317T1 (de) 1996-03-29 2006-10-15 Ortho Mcneil Pharm Inc Amidinohydrazone als protease-inhibitoren
CA2252964A1 (en) 1996-04-23 1997-10-30 Merck & Co., Inc. Pyrazinone thrombin inhibitors
AU724191B2 (en) * 1996-08-29 2000-09-14 Merck & Co., Inc. Integrin antagonists
AU723234B2 (en) * 1996-09-06 2000-08-24 Nippon Kayaku Kabushiki Kaisha Novel acetamide derivatives and protease inhibitors
WO1998009987A1 (en) * 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
TW499412B (en) * 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
EP1017393A4 (de) * 1997-09-05 2002-01-23 Merck & Co Inc Pyrazinon thrombininhibitoren
PL340560A1 (en) * 1997-11-26 2001-02-12 Dimensional Pharmaceuticals 3 Heteroaryl aminoguanidines and alkoxyguanidines and their application as protease inhibitors
AU2001278997A1 (en) * 2000-07-28 2002-02-13 Merck And Co., Inc. Thrombin inhibitors

Also Published As

Publication number Publication date
ATE302794T1 (de) 2005-09-15
DE69926884T2 (de) 2006-06-14
ZA200007306B (en) 2001-06-13
BR9911100A (pt) 2001-02-13
CN1305492A (zh) 2001-07-25
US20010021713A1 (en) 2001-09-13
IL139867A0 (en) 2002-02-10
ATE461210T1 (de) 2010-04-15
ES2249012T3 (es) 2006-03-16
US6204263B1 (en) 2001-03-20
CN1224629C (zh) 2005-10-26
DE69942159D1 (de) 2010-04-29
WO1999064446A1 (en) 1999-12-16
AU759427B2 (en) 2003-04-17
EP1589029A3 (de) 2006-01-18
HUP0103283A3 (en) 2002-05-28
AU4561899A (en) 1999-12-30
CN1769274A (zh) 2006-05-10
NO20006300L (no) 2001-02-12
KR20010052772A (ko) 2001-06-25
EP1086122A1 (de) 2001-03-28
CA2334679A1 (en) 1999-12-16
NO20006300D0 (no) 2000-12-11
KR100669953B1 (ko) 2007-01-18
EA200100025A1 (ru) 2001-06-25
EP1086122B1 (de) 2005-08-24
EP1589029B1 (de) 2010-03-17
EA004884B1 (ru) 2004-08-26
ES2343120T3 (es) 2010-07-23
JP2002517512A (ja) 2002-06-18
CA2334679C (en) 2012-10-23
PL344749A1 (en) 2001-11-19
US6514978B2 (en) 2003-02-04
EP1589029A2 (de) 2005-10-26
DK1086122T3 (da) 2006-01-09
HUP0103283A2 (hu) 2002-04-29
NZ508669A (en) 2003-06-30
JP4554077B2 (ja) 2010-09-29
SI1086122T1 (sl) 2006-02-28

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ORTHO-MCNEIL PHARMACEUTICAL, INC., RARITAN, N.J.,