WO1998040510A1
(en)
|
1997-03-11 |
1998-09-17 |
Regents Of The University Of Minnesota |
Dna-based transposon system for the introduction of nucleic acid into dna of a cell
|
US7160682B2
(en)
|
1998-11-13 |
2007-01-09 |
Regents Of The University Of Minnesota |
Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell
|
GB9904627D0
(en)
*
|
1999-03-02 |
1999-04-21 |
Danbiosyst Uk |
Polymer compositions for polynucleotide delivery
|
US6852334B1
(en)
*
|
1999-04-20 |
2005-02-08 |
The University Of British Columbia |
Cationic peg-lipids and methods of use
|
EP1063254A1
(de)
*
|
1999-06-25 |
2000-12-27 |
Technische Uni München, Klinikum rechts der Isar, Inst. für Experiment. Onkoligie und Therapieforschung |
Copolymere für den Transport von Nukleinsäuren in die Zelle
|
US7189705B2
(en)
*
|
2000-04-20 |
2007-03-13 |
The University Of British Columbia |
Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
|
EP1286699A2
(en)
*
|
2000-05-19 |
2003-03-05 |
Regents Of The University Of Minnesota |
Composition for delivery of compounds to cells
|
US20020042388A1
(en)
*
|
2001-05-01 |
2002-04-11 |
Cooper Mark J. |
Lyophilizable and enhanced compacted nucleic acids
|
US20040142474A1
(en)
*
|
2000-09-14 |
2004-07-22 |
Expression Genetics, Inc. |
Novel cationic lipopolymer as a biocompatible gene delivery agent
|
US6696038B1
(en)
*
|
2000-09-14 |
2004-02-24 |
Expression Genetics, Inc. |
Cationic lipopolymer as biocompatible gene delivery agent
|
KR100553376B1
(ko)
*
|
2001-02-28 |
2006-02-20 |
재단법인서울대학교산학협력재단 |
다양이온 초가지성 폴리아미노에스테르
|
US6544954B1
(en)
|
2002-02-19 |
2003-04-08 |
Oliver Yoa-Pu Hu |
Stable galactose injection solutions
|
US8227432B2
(en)
|
2002-04-22 |
2012-07-24 |
Regents Of The University Of Minnesota |
Transposon system and methods of use
|
AR037006A1
(es)
*
|
2002-06-20 |
2004-10-20 |
S I G Sist S De Identificacion |
Marcador de objetos a identificar consistente en al menos un fragmento de adn.
|
US20040014704A1
(en)
*
|
2002-07-18 |
2004-01-22 |
Gonzalo Hortelano |
Oral administration of therapeutic agent coupled to transporting agent induces tolerance
|
US20040016013A1
(en)
*
|
2002-07-18 |
2004-01-22 |
Gonzalo Hortelano |
Transgenic animals produced using oral administration of a genetic agent coupled to a transporting agent
|
US20040014698A1
(en)
*
|
2002-07-18 |
2004-01-22 |
Gonzalo Hortelano |
Oral administration of therapeutic agent coupled to transporting agent
|
WO2005012407A2
(en)
*
|
2003-06-30 |
2005-02-10 |
Canji, Inc. |
Polymer encapsulation of adenoviruses
|
JP2005151891A
(ja)
*
|
2003-11-27 |
2005-06-16 |
Japan Science & Technology Agency |
細胞認識糖側鎖を持つ多糖系遺伝子キャリアー
|
US20050208032A1
(en)
*
|
2004-01-16 |
2005-09-22 |
Gonzalo Hortelano |
Oral administration of therapeutic agent coupled to transporting agent
|
US20060229267A1
(en)
*
|
2004-06-01 |
2006-10-12 |
Reza Sheikhnejad |
Methods and compositions for the inhibition of gene expression
|
US8815599B2
(en)
|
2004-06-01 |
2014-08-26 |
Pronai Therapeutics, Inc. |
Methods and compositions for the inhibition of gene expression
|
US7807647B2
(en)
*
|
2004-06-01 |
2010-10-05 |
Pronai Therapeutics, Inc. |
Methods and compositions for cancer therapy
|
US7304045B2
(en)
*
|
2004-10-05 |
2007-12-04 |
Hsing-Wen Sung |
Nanoparticles for targeting hepatoma cells
|
US8318198B1
(en)
|
2004-10-05 |
2012-11-27 |
Gp Medical, Inc. |
Pharmaceutical composition of nanoparticles
|
US8318200B1
(en)
|
2004-10-05 |
2012-11-27 |
Gp Medical, Inc. |
Pharmaceutical composition of nanoparticles
|
US7985426B1
(en)
|
2004-10-05 |
2011-07-26 |
Hsing-Wen Sung |
Nanoparticles for targeting hepatoma cells and delivery means
|
US8198246B1
(en)
|
2004-10-05 |
2012-06-12 |
Gp Medical, Inc. |
Pharmaceutical composition of nanoparticles
|
US8663599B1
(en)
|
2004-10-05 |
2014-03-04 |
Gp Medical, Inc. |
Pharmaceutical composition of nanoparticles
|
US7348026B2
(en)
*
|
2004-10-05 |
2008-03-25 |
Hsing-Wen Sung |
Nanoparticles for targeting hepatoma cells
|
US7964571B2
(en)
|
2004-12-09 |
2011-06-21 |
Egen, Inc. |
Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
|
SI2727583T1
(sl)
|
2004-12-22 |
2022-01-31 |
Nitto Denko Corporation |
Nosilec učinkovine in komplet nosilca učinkovine za zaviranje fibroze
|
US20120269886A1
(en)
|
2004-12-22 |
2012-10-25 |
Nitto Denko Corporation |
Therapeutic agent for pulmonary fibrosis
|
EP1957044B1
(en)
|
2005-12-01 |
2013-03-13 |
Pronai Therapeutics, Inc. |
Amphoteric liposome formulation
|
EP3000480A1
(en)
|
2005-12-01 |
2016-03-30 |
ProNAi Therapeutics, Inc. |
Cancer therapies and pharmaceutical compositions used therein
|
US9572886B2
(en)
|
2005-12-22 |
2017-02-21 |
Nitto Denko Corporation |
Agent for treating myelofibrosis
|
CN101138636B
(zh)
*
|
2006-09-05 |
2010-05-12 |
中国科学院上海药物研究所 |
一种基因药物的输送系统及其制备方法
|
TWI407971B
(zh)
|
2007-03-30 |
2013-09-11 |
Nitto Denko Corp |
Cancer cells and tumor-related fibroblasts
|
US7960336B2
(en)
*
|
2007-08-03 |
2011-06-14 |
Pharmain Corporation |
Composition for long-acting peptide analogs
|
US9144546B2
(en)
|
2007-08-06 |
2015-09-29 |
Clsn Laboratories, Inc. |
Nucleic acid-lipopolymer compositions
|
US8563527B2
(en)
*
|
2007-08-20 |
2013-10-22 |
Pharmain Corporation |
Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
|
AU2008298592A1
(en)
|
2007-09-14 |
2009-03-19 |
Nitto Denko Corporation |
Drug carriers
|
WO2009062084A2
(en)
*
|
2007-11-07 |
2009-05-14 |
University Of Utah Research Foundation |
Cleavable modifications to reducible poly(amido ethylenimine)s to enhance nucleotide delivery
|
US20090130752A1
(en)
*
|
2007-11-07 |
2009-05-21 |
University Of Utah Research Foundation |
Biodegradable poly(disulfide amine)s for gene delivery
|
US20090156459A1
(en)
*
|
2007-11-16 |
2009-06-18 |
Pharmain Corporation |
Cationic-Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
|
HUE035770T2
(en)
*
|
2008-06-16 |
2018-05-28 |
Pfizer |
Process for the preparation of diblock copolymers functionalized with targeting material for use in the preparation of therapeutic nanoparticles
|
KR20110024642A
(ko)
*
|
2009-09-02 |
2011-03-09 |
삼성전자주식회사 |
디스플레이장치 및 그 제어 방법
|
JP5510808B2
(ja)
*
|
2010-03-10 |
2014-06-04 |
独立行政法人産業技術総合研究所 |
有機ナノチューブからなる核酸導入剤
|
US20110229528A1
(en)
*
|
2010-03-12 |
2011-09-22 |
Intezyne Technologies, Incorporated |
Pegylated polyplexes for polynucleotide delivery
|
US20130149783A1
(en)
*
|
2010-03-16 |
2013-06-13 |
James William Yockman |
Cleavable modifications to reducible poly (amido ethylenimines)s to enhance nucleotide delivery
|
EP3578205A1
(en)
|
2010-08-06 |
2019-12-11 |
ModernaTX, Inc. |
A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
|
CN101974152B
(zh)
*
|
2010-09-28 |
2012-07-11 |
山东大学 |
一种类脂-阳离子聚合物及其制备方法
|
HUE058896T2
(hu)
|
2010-10-01 |
2022-09-28 |
Modernatx Inc |
N1-metil-pszeudo-uracilt tartalmazó ribonukleinsavak és azok felhasználásai
|
WO2012051457A1
(en)
*
|
2010-10-14 |
2012-04-19 |
Nitto Denko Corporation |
Nucleic acid delivery compounds
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
EP2791160B1
(en)
|
2011-12-16 |
2022-03-02 |
ModernaTX, Inc. |
Modified mrna compositions
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
AU2013243951A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of secreted proteins
|
WO2013151666A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of biologics and proteins associated with human disease
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
CA2890725A1
(en)
|
2012-11-05 |
2014-05-08 |
Pronai Therapeutics, Inc. |
Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression
|
EP2922554B1
(en)
|
2012-11-26 |
2022-02-23 |
ModernaTX, Inc. |
Terminally modified rna
|
EP3434774A1
(en)
|
2013-01-17 |
2019-01-30 |
ModernaTX, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
WO2014159813A1
(en)
|
2013-03-13 |
2014-10-02 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
EP3971287A1
(en)
|
2013-07-11 |
2022-03-23 |
ModernaTX, Inc. |
Compositions comprising synthetic polynucleotides encoding crispr related proteins and synthetic sgrnas and methods of use
|
WO2015034928A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2015048744A2
(en)
|
2013-09-30 |
2015-04-02 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
EA201690675A1
(ru)
|
2013-10-03 |
2016-08-31 |
Модерна Терапьютикс, Инк. |
Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
|
JP2017500865A
(ja)
|
2013-12-19 |
2017-01-12 |
ノバルティス アーゲー |
レプチンmRNAの組成物および製剤
|
US20170204152A1
(en)
|
2014-07-16 |
2017-07-20 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
WO2016014846A1
(en)
|
2014-07-23 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of intrabodies
|
KR20180063885A
(ko)
|
2015-09-24 |
2018-06-12 |
더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 |
전이 감소를 위한 방법 및 조성물
|
EP3625246A1
(en)
|
2017-05-18 |
2020-03-25 |
ModernaTX, Inc. |
Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
|
EP4253544A3
(en)
|
2017-05-18 |
2023-12-20 |
ModernaTX, Inc. |
Modified messenger rna comprising functional rna elements
|
WO2018232006A1
(en)
|
2017-06-14 |
2018-12-20 |
Modernatx, Inc. |
Polynucleotides encoding coagulation factor viii
|
EP3679140B1
(en)
|
2017-09-08 |
2022-11-16 |
MiNA Therapeutics Limited |
Stabilized cebpa sarna compositions and methods of use
|
US11939601B2
(en)
|
2017-11-22 |
2024-03-26 |
Modernatx, Inc. |
Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria
|
CA3079543A1
(en)
|
2017-11-22 |
2019-05-31 |
Modernatx, Inc. |
Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia
|
EP3714048A1
(en)
|
2017-11-22 |
2020-09-30 |
Modernatx, Inc. |
Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
|
US11802146B2
(en)
|
2018-01-05 |
2023-10-31 |
Modernatx, Inc. |
Polynucleotides encoding anti-chikungunya virus antibodies
|
JP7267609B2
(ja)
*
|
2018-01-30 |
2023-05-02 |
国立大学法人大阪大学 |
抗がん剤
|
EP4242307A3
(en)
|
2018-04-12 |
2023-12-27 |
MiNA Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
MA52709A
(fr)
|
2018-05-23 |
2021-03-31 |
Modernatx Inc |
Administration d'adn
|
WO2020023390A1
(en)
|
2018-07-25 |
2020-01-30 |
Modernatx, Inc. |
Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
|
WO2020033791A1
(en)
|
2018-08-09 |
2020-02-13 |
Verseau Therapeutics, Inc. |
Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
|
US20220110966A1
(en)
|
2018-09-02 |
2022-04-14 |
Modernatx, Inc. |
Polynucleotides encoding very long-chain acyl-coa dehydrogenase for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
AU2019337637A1
(en)
|
2018-09-13 |
2021-04-22 |
Modernatx, Inc. |
Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease
|
US20220243182A1
(en)
|
2018-09-13 |
2022-08-04 |
Modernatx, Inc. |
Polynucleotides encoding branched-chain alpha-ketoacid dehydrogenase complex e1-alpha, e1-beta, and e2 subunits for the treatment of maple syrup urine disease
|
JP2022500444A
(ja)
|
2018-09-14 |
2022-01-04 |
モダーナティエックス・インコーポレイテッドModernaTX, Inc. |
クリグラー−ナジャー症候群の治療のためのウリジン二リン酸グリコシルトランスフェラーゼ1ファミリー、ポリペプチドa1をコードするポリヌクレオチド
|
MA53734A
(fr)
|
2018-09-27 |
2021-08-04 |
Modernatx Inc |
Polynucléotides codant pour l'arginase 1 pour le traitement d'une déficience en arginase
|
WO2020208361A1
(en)
|
2019-04-12 |
2020-10-15 |
Mina Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
JP2022532078A
(ja)
|
2019-05-08 |
2022-07-13 |
アストラゼネカ アクチボラグ |
皮膚及び創傷のための組成物並びにその使用の方法
|
JP2023527875A
(ja)
|
2020-06-01 |
2023-06-30 |
モダーナティエックス・インコーポレイテッド |
フェニルアラニンヒドロキシラーゼバリアント及びその使用
|
CA3199784A1
(en)
|
2020-11-13 |
2022-05-19 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
WO2022204369A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
|
WO2022204371A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
|
WO2022204380A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
|
JP2024512026A
(ja)
|
2021-03-24 |
2024-03-18 |
モデルナティエックス インコーポレイテッド |
オルニチントランスカルバミラーゼ欠損症の治療を目的とした脂質ナノ粒子及びオルニチントランスカルバミラーゼをコードするポリヌクレオチド
|
WO2022204390A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
|
US20240175033A1
(en)
|
2021-03-26 |
2024-05-30 |
Mina Therapeutics Limited |
TMEM173 saRNA Compositions and Methods of Use
|
WO2022266083A2
(en)
|
2021-06-15 |
2022-12-22 |
Modernatx, Inc. |
Engineered polynucleotides for cell-type or microenvironment-specific expression
|
WO2022271776A1
(en)
|
2021-06-22 |
2022-12-29 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
|
WO2023056044A1
(en)
|
2021-10-01 |
2023-04-06 |
Modernatx, Inc. |
Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease
|
EP4183884A1
(en)
|
2021-11-19 |
2023-05-24 |
Branca Bunus Limited |
A method of preparing a fraction of a starting polymer vector for gene therapy
|
WO2023099884A1
(en)
|
2021-12-01 |
2023-06-08 |
Mina Therapeutics Limited |
Pax6 sarna compositions and methods of use
|
GB202117758D0
(en)
|
2021-12-09 |
2022-01-26 |
Ucl Business Ltd |
Therapeutics for the treatment of neurodegenerative disorders
|
WO2023170435A1
(en)
|
2022-03-07 |
2023-09-14 |
Mina Therapeutics Limited |
Il10 sarna compositions and methods of use
|
WO2024026254A1
(en)
|
2022-07-26 |
2024-02-01 |
Modernatx, Inc. |
Engineered polynucleotides for temporal control of expression
|