IL139761A0 - A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier - Google Patents

A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier

Info

Publication number
IL139761A0
IL139761A0 IL13976199A IL13976199A IL139761A0 IL 139761 A0 IL139761 A0 IL 139761A0 IL 13976199 A IL13976199 A IL 13976199A IL 13976199 A IL13976199 A IL 13976199A IL 139761 A0 IL139761 A0 IL 139761A0
Authority
IL
Israel
Prior art keywords
pll
peg
targeting moiety
lysine
gene
Prior art date
Application number
IL13976199A
Other languages
English (en)
Original Assignee
Expression Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expression Genetics Inc filed Critical Expression Genetics Inc
Publication of IL139761A0 publication Critical patent/IL139761A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
IL13976199A 1998-05-20 1999-05-20 A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier IL139761A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8607298P 1998-05-20 1998-05-20
PCT/US1999/011147 WO1999059546A1 (en) 1998-05-20 1999-05-20 A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier

Publications (1)

Publication Number Publication Date
IL139761A0 true IL139761A0 (en) 2002-02-10

Family

ID=22196073

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13976199A IL139761A0 (en) 1998-05-20 1999-05-20 A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier

Country Status (17)

Country Link
US (1) US6177274B1 (es)
EP (1) EP1083882B1 (es)
JP (1) JP2002515418A (es)
KR (1) KR20010071279A (es)
CN (1) CN1333678A (es)
AT (1) ATE411049T1 (es)
AU (1) AU4193199A (es)
BR (1) BR9911062A (es)
CA (1) CA2329147A1 (es)
DE (1) DE69939740D1 (es)
FI (1) FI20002539A (es)
IL (1) IL139761A0 (es)
MX (1) MXPA00011312A (es)
NO (1) NO20005809D0 (es)
TR (1) TR200003441T2 (es)
WO (1) WO1999059546A1 (es)
ZA (1) ZA200006685B (es)

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Publication number Publication date
CN1333678A (zh) 2002-01-30
WO1999059546A1 (en) 1999-11-25
DE69939740D1 (de) 2008-11-27
KR20010071279A (ko) 2001-07-28
TR200003441T2 (tr) 2001-04-20
EP1083882A4 (en) 2004-08-18
NO20005809D0 (no) 2000-11-17
JP2002515418A (ja) 2002-05-28
EP1083882A1 (en) 2001-03-21
US6177274B1 (en) 2001-01-23
ZA200006685B (en) 2001-07-13
FI20002539A (fi) 2001-01-19
BR9911062A (pt) 2001-02-06
MXPA00011312A (es) 2003-04-22
CA2329147A1 (en) 1999-11-25
AU4193199A (en) 1999-12-06
EP1083882B1 (en) 2008-10-15
ATE411049T1 (de) 2008-10-15

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