FI20002539A - Hepatosyyttiin kohdentuva polyetyleeniglykohaaroittunut poly-L-lysiinipolymeerigeenikantaja - Google Patents

Hepatosyyttiin kohdentuva polyetyleeniglykohaaroittunut poly-L-lysiinipolymeerigeenikantaja Download PDF

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Publication number
FI20002539A
FI20002539A FI20002539A FI20002539A FI20002539A FI 20002539 A FI20002539 A FI 20002539A FI 20002539 A FI20002539 A FI 20002539A FI 20002539 A FI20002539 A FI 20002539A FI 20002539 A FI20002539 A FI 20002539A
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FI
Finland
Prior art keywords
pll
peg
targeting moiety
polyethylene glycol
gene
Prior art date
Application number
FI20002539A
Other languages
English (en)
Swedish (sv)
Inventor
Jong Sang Park
Youn-Hun Choi
Feng Liu
Original Assignee
Expression Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expression Genetics Inc filed Critical Expression Genetics Inc
Publication of FI20002539A publication Critical patent/FI20002539A/fi

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
FI20002539A 1998-05-20 2000-11-20 Hepatosyyttiin kohdentuva polyetyleeniglykohaaroittunut poly-L-lysiinipolymeerigeenikantaja FI20002539A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8607298P 1998-05-20 1998-05-20
PCT/US1999/011147 WO1999059546A1 (en) 1998-05-20 1999-05-20 A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier

Publications (1)

Publication Number Publication Date
FI20002539A true FI20002539A (fi) 2001-01-19

Family

ID=22196073

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20002539A FI20002539A (fi) 1998-05-20 2000-11-20 Hepatosyyttiin kohdentuva polyetyleeniglykohaaroittunut poly-L-lysiinipolymeerigeenikantaja

Country Status (17)

Country Link
US (1) US6177274B1 (fi)
EP (1) EP1083882B1 (fi)
JP (1) JP2002515418A (fi)
KR (1) KR20010071279A (fi)
CN (1) CN1333678A (fi)
AT (1) ATE411049T1 (fi)
AU (1) AU4193199A (fi)
BR (1) BR9911062A (fi)
CA (1) CA2329147A1 (fi)
DE (1) DE69939740D1 (fi)
FI (1) FI20002539A (fi)
IL (1) IL139761A0 (fi)
MX (1) MXPA00011312A (fi)
NO (1) NO20005809D0 (fi)
TR (1) TR200003441T2 (fi)
WO (1) WO1999059546A1 (fi)
ZA (1) ZA200006685B (fi)

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CN1333678A (zh) 2002-01-30
ATE411049T1 (de) 2008-10-15
JP2002515418A (ja) 2002-05-28
ZA200006685B (en) 2001-07-13
MXPA00011312A (es) 2003-04-22
EP1083882B1 (en) 2008-10-15
US6177274B1 (en) 2001-01-23
CA2329147A1 (en) 1999-11-25
EP1083882A1 (en) 2001-03-21
BR9911062A (pt) 2001-02-06
TR200003441T2 (tr) 2001-04-20
DE69939740D1 (de) 2008-11-27
WO1999059546A1 (en) 1999-11-25
IL139761A0 (en) 2002-02-10
KR20010071279A (ko) 2001-07-28
AU4193199A (en) 1999-12-06
NO20005809D0 (no) 2000-11-17
EP1083882A4 (en) 2004-08-18

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