YU48183B - Postupak za kontinuiranu izradu transdermalnih terapijskih flastera - Google Patents

Postupak za kontinuiranu izradu transdermalnih terapijskih flastera

Info

Publication number
YU48183B
YU48183B YU27792A YU27792A YU48183B YU 48183 B YU48183 B YU 48183B YU 27792 A YU27792 A YU 27792A YU 27792 A YU27792 A YU 27792A YU 48183 B YU48183 B YU 48183B
Authority
YU
Yugoslavia
Prior art keywords
active substance
layer
reservoir
protective layer
adhesive
Prior art date
Application number
YU27792A
Other languages
English (en)
Other versions
YU27792A (sh
Inventor
D. Anhäuser
L. Deurer
T. Hille
P. Steinborn
Original Assignee
Lts. Lohmann Therapie - Systeme Gmbh. & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts. Lohmann Therapie - Systeme Gmbh. & Co. Kg. filed Critical Lts. Lohmann Therapie - Systeme Gmbh. & Co. Kg.
Priority to SI9210277A priority Critical patent/SI9210277B/sl
Priority to HR930668 priority patent/HRP930668B1/xx
Publication of YU27792A publication Critical patent/YU27792A/sh
Publication of YU48183B publication Critical patent/YU48183B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/108—Flash, trim or excess removal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1084—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing of continuous or running length bonded web
    • Y10T156/1085—One web only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1089—Methods of surface bonding and/or assembly therefor of discrete laminae to single face of additional lamina
    • Y10T156/1092—All laminae planar and face to face
    • Y10T156/1093—All laminae planar and face to face with covering of discrete laminae with additional lamina
    • Y10T156/1095—Opposed laminae are running length webs

Abstract

POSTUPAK ZA KONTINUIRANU IZRADU TRANSDERMALNIH TERAPIJSKIH FLASTERA koji obuhvataju zadnji sloj 1, prianjanjem lepljivi sloj rezervoara 6 aktivne materije kao i ponovo odvojivi zaštitni sloj 3, pri čemu se gubitak aktivne materije pri konfekcioniranju svodi na naj-manje meru, naznačen time, što se kod laminata u obliku trake sa prianjajućim lepljivim zadnjim slojem (1) i ponovo odvojivim zaštitnim slojem (3), vrši umetanje u uzdužnom pravcu izmedju slojeva (1,3) pojedinačnih uzastop-nih četvorougaonih otsečaka (2) rezervoara (6) aktivne materije koji se lepe prianjanjem i koji se postavljaju, u uzdužnom pravcu na istim medjusobnim unutrašnjim rastojan-jima čija je širina dimenzionisana tako da ih sa obe strane prekriva zadnji sloj (1) i ponovo odvojivi zaštitni sloj (3); što se najpre prosecanjem potpuno odvaja prianjanjem lepljivi zadnji sloj (1), pri čemu linija prosecanja (1a) oblo obuhvata pojedinačne otsečke (2) rezervoara (6) aktivne materije na odredjenom rastojanju od njihovih spoljnih ivica, i što se odstranjuje nastali mrežasti isečak prianjajućeg zadnjeg sloja (1) bez aktivne materije i što se na kraju vrši potpuno odvajanje zaštitnog sloja (3) u medjuprostorima izmedju otsečaka (2) rezervoara (6) aktivne materije. - Prijava sadrži još 1 zavisan zahtev.
YU27792A 1991-03-27 1992-03-18 Postupak za kontinuiranu izradu transdermalnih terapijskih flastera YU48183B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9210277A SI9210277B (sl) 1991-03-27 1992-03-18 Transdermalni terapevtski obliži
HR930668 HRP930668B1 (en) 1991-03-27 1993-04-01 Transdermal therapeutic plaster

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4110027A DE4110027C2 (de) 1991-03-27 1991-03-27 Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster

Publications (2)

Publication Number Publication Date
YU27792A YU27792A (sh) 1995-01-31
YU48183B true YU48183B (sh) 1997-07-31

Family

ID=6428306

Family Applications (1)

Application Number Title Priority Date Filing Date
YU27792A YU48183B (sh) 1991-03-27 1992-03-18 Postupak za kontinuiranu izradu transdermalnih terapijskih flastera

Country Status (26)

Country Link
US (1) US6315854B1 (sh)
EP (1) EP0577622B1 (sh)
JP (1) JPH0665349B2 (sh)
KR (1) KR970006100B1 (sh)
AT (1) ATE146365T1 (sh)
AU (1) AU657314B2 (sh)
CA (1) CA2106374C (sh)
CZ (1) CZ281267B6 (sh)
DE (2) DE4110027C2 (sh)
DK (1) DK0577622T3 (sh)
ES (1) ES2098500T3 (sh)
FI (1) FI107020B (sh)
GR (1) GR3022863T3 (sh)
HR (1) HRP930668B1 (sh)
HU (1) HU210845B (sh)
IE (1) IE78823B1 (sh)
IL (1) IL101189A (sh)
MY (1) MY106656A (sh)
NO (1) NO306849B1 (sh)
NZ (1) NZ242127A (sh)
PH (1) PH31285A (sh)
SI (1) SI9210277B (sh)
SK (1) SK278995B6 (sh)
WO (1) WO1992017237A1 (sh)
YU (1) YU48183B (sh)
ZA (1) ZA922190B (sh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4229230C2 (de) * 1992-09-02 1997-01-16 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit Pentetrazol als Wirkstoff
DE19547691C1 (de) * 1995-12-20 1997-04-24 Lohmann Therapie Syst Lts Verfahren zur Herstellung transdermaler therapeutischer Pflaster (TTS)
DE19702314C2 (de) * 1997-01-23 2000-12-21 Lohmann Therapie Syst Lts Ablösbare Schutzfolie für wirkstoffhaltige, insbesondere selbstklebende Pflastersysteme
DE19736315A1 (de) * 1997-08-21 1999-02-25 Lohmann Therapie Syst Lts Wirkstoffhaltige Dochtsysteme
DE19738855C2 (de) 1997-09-05 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit haftklebender Reservoirschicht und unidirektional elastischer Rückschicht
DE19749525C1 (de) 1997-11-08 1999-06-10 Lohmann Therapie Syst Lts Laserstrahl-Schneideverfahren zum Schneiden von Laminat zur Applikation auf die Haut und Fixiervorrichtung
GB2336310B (en) * 1998-04-14 2003-09-10 Stowic Resources Ltd Method of manufacturing transdermal patches
DE19923427A1 (de) 1999-05-21 2000-11-23 Lohmann Therapie Syst Lts Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen
DE19925338A1 (de) * 1999-06-02 2000-12-07 Lohmann Therapie Syst Lts Substratabschnitte mit erhöhter Lagerstabilität während ihrer Lagerung in Beutelverpackung, sowie Verfahren zu ihrer Herstellung
DE60141596D1 (de) * 2000-10-23 2010-04-29 Euro Celtique Sa Transdermales system zur verabreichung von loratadin und dessen verwendung
GB2414397B (en) * 2004-05-26 2009-03-11 Johnson And Johnson Medical Ltd Self-irrigating wound dressing
CN101232875B (zh) * 2005-06-10 2014-06-25 3M创新有限公司 处理粘合层叠片片段的方法
DE102007006244B4 (de) * 2007-02-08 2012-03-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System zur Verabreichung wasserlöslicher Wirkstoffe
ATE485797T1 (de) * 2007-08-21 2010-11-15 Lohmann Therapie Syst Lts Verfahren zum mehrspurigen konfektionieren transdermaler therapeutischer pflaster
DE102010000661A1 (de) * 2010-01-04 2011-07-07 Acino Ag, 83714 Verfahren und Vorrichtung zur Herstellung einer überlappenden Schutzfolie für ein transdermales therapeutisches System
DE102010064358A1 (de) 2010-12-29 2012-07-05 Acino Ag Transdermales Applikationssystem mit überstehender Backingfolie
EP2682113B1 (de) * 2012-07-02 2018-10-31 Luye Pharma AG Verschließen wirkstoffhaltiger Laminate
EP2818159A1 (de) * 2013-06-25 2014-12-31 LTS LOHMANN Therapie-Systeme AG Vorrichtung mit transdermalem therapeutischem System, Positionier- und Penetrationshilfe
EP2921184A1 (de) * 2014-03-19 2015-09-23 LTS LOHMANN Therapie-Systeme AG Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung
EP3233492B1 (en) 2014-12-18 2021-11-10 Kindeva Drug Delivery L.P. Methods of handling adhesive laminate patches
CN112402095B (zh) * 2020-11-17 2022-05-31 新领医药技术(深圳)有限公司 一种硫酸镁冷敷贴及其制备工艺

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2862846A (en) * 1953-11-23 1958-12-02 Johnson & Johnson Method of making plastic strip adhesive bandages
US2703083A (en) * 1955-01-04 1955-03-01 William J Gross Adhesive bandage
US3245855A (en) * 1962-01-18 1966-04-12 Carl B Stenvall Method for making adhesive bandage
CA1192825A (en) * 1980-11-10 1985-09-03 Minnesota Mining And Manufacturing Company Device and method for applying conformable, thin adhesive-coated films
US4725272A (en) 1981-06-29 1988-02-16 Alza Corporation Novel bandage for administering beneficial drug
DE3204582A1 (de) * 1982-02-10 1983-08-25 Hassia Verpackung Gmbh, 6479 Ranstadt Verfahren zur kontinuierlichen herstellung von pflasterpackungen fuer die transdermale verabreichung von medikamenten
US4556441A (en) * 1983-01-24 1985-12-03 Faasse Jr Adrian L Pharmaceutical packaging method
US4704119A (en) * 1983-02-03 1987-11-03 Alza Corporation Method comprising transdermal and buccal treatment of angina
DE3315272C2 (de) * 1983-04-27 1986-03-27 Lohmann Gmbh & Co Kg, 5450 Neuwied Pharmazeutisches Produkt und Verfahren zu seiner Herstellung
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
DE3586707T2 (de) * 1984-10-05 1993-02-11 Hercon Lab System zur transdermalen applikation eines arzneimittels.
US4638043A (en) * 1984-11-13 1987-01-20 Thermedics, Inc. Drug release system
US4614076A (en) * 1985-05-23 1986-09-30 Becton, Dickinson And Company Flexible packaging apparatus and method
DE3770836D1 (de) * 1986-02-14 1991-07-25 Ciba Geigy Ag Dermale und transdermale therapeutische systeme mit musterfoermig aufgetragener klebschicht, sowie verfahren zur dessen herstellung.
DE3634016A1 (de) * 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung
DE3629304A1 (de) * 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
CH672888A5 (sh) * 1986-11-07 1990-01-15 Mepha Ag
DE3714140A1 (de) * 1987-04-28 1988-11-10 Lohmann Therapie Syst Lts Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut
DE3743946A1 (de) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
DE3810658A1 (de) * 1988-03-29 1989-10-12 Lohmann Gmbh & Co Kg Pflaster, insbesondere epikutantestpflaster und verfahren zur herstellung desselben
US4867821A (en) * 1988-07-11 1989-09-19 Morgan Burton D Process for fabricating self-adhesive bandages
DE3908432A1 (de) * 1989-03-14 1990-09-27 Lohmann Therapie Syst Lts Pflaster als therapeutisches system zur verabreichung von wirkstoffen an die haut mit einer abgestuften wirkstoffabgabe, verfahren zu seiner herstellung sowie verwendung
DE3910543A1 (de) * 1989-04-01 1990-10-11 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung
DE3924393A1 (de) * 1989-07-24 1991-01-31 Roehm Gmbh Wasserloeslicher druckempfindlicher hauthaftkleber, dessen verwendung und damit ausgeruestete mittel
US5112618A (en) * 1989-11-01 1992-05-12 Ndm Acquisition Corp. Hydrogel wound dressing product
US5268179A (en) * 1992-02-14 1993-12-07 Ciba-Geigy Corporation Ultrasonically sealed transdermal drug delivery systems

Also Published As

Publication number Publication date
IE920963A1 (en) 1992-10-07
HU9302700D0 (en) 1993-12-28
FI934189A0 (fi) 1993-09-24
JPH0665349B2 (ja) 1994-08-24
KR970006100B1 (ko) 1997-04-23
ES2098500T3 (es) 1997-05-01
ZA922190B (en) 1992-12-30
MY106656A (en) 1995-07-31
EP0577622A1 (de) 1994-01-12
GR3022863T3 (sh) 1997-06-30
CA2106374C (en) 1997-03-18
HRP930668A2 (en) 1994-10-31
HRP930668B1 (en) 2001-02-28
YU27792A (sh) 1995-01-31
SI9210277A (en) 1994-06-30
CA2106374A1 (en) 1992-09-28
CZ281267B6 (cs) 1996-07-17
NO933414L (no) 1993-09-24
EP0577622B1 (de) 1996-12-18
WO1992017237A1 (de) 1992-10-15
NO933414D0 (no) 1993-09-24
SK101193A3 (en) 1994-04-06
CZ193293A3 (en) 1994-03-16
AU1353592A (en) 1992-11-02
HUT65961A (en) 1994-08-29
JPH06501185A (ja) 1994-02-10
SK278995B6 (sk) 1998-05-06
PH31285A (en) 1998-07-06
SI9210277B (sl) 2000-10-31
DE4110027A1 (de) 1992-10-01
DK0577622T3 (da) 1997-06-16
FI934189A (fi) 1993-09-24
HU210845B (en) 1995-08-28
AU657314B2 (en) 1995-03-09
IL101189A (en) 1995-05-26
NZ242127A (en) 1994-04-27
NO306849B1 (no) 2000-01-03
US6315854B1 (en) 2001-11-13
ATE146365T1 (de) 1997-01-15
IE78823B1 (en) 1998-02-25
DE4110027C2 (de) 1996-08-29
FI107020B (fi) 2001-05-31
DE59207727D1 (de) 1997-01-30

Similar Documents

Publication Publication Date Title
YU48183B (sh) Postupak za kontinuiranu izradu transdermalnih terapijskih flastera
NZ187114A (en) Polyenes with tumour-inhibiting activity intermediates and phosohonium salts
IT1178911B (it) Dispositivo osmotico avente duplice attivita termodinamica per la erogazione a velocita controllata di una sostanza particolarmente un farmaco all ambiente a cui e destinata
BR9405721A (pt) Uso terapeutico de compostos com atividade seletiva semelhante a de agonista sobre receptores rxr de retinóide
FR2570986B1 (fr) Article adhesif ne pouvant pas etre fixe de nouveau par adherence
BR9815897A (pt) Grama sintética
MX163126B (es) Mejoras en unidad y procedimiento de pulverizacion para llevar a cabo una atomizacion de gota controlada
ES555017A0 (es) Una cabeza aplicadora para hacer fluir una pelicula delgada continua de una composicion de tinte sobre las superficies de un articulo conformado
EP0001647A3 (en) Imidazoline derivatives and salts thereof, their synthesis, and intermediates, and pesticidal formulations
MX9207243A (es) Metodo para impartir actividad antimicrobiana a una composicion oftalmica
IT1132369B (it) Impianto solubilizzatore a flusso per produrre una soluzione zuccherina
IT8148975A0 (it) Assorbente igienico monouso fornito di striscie di adesivo a pressione
AR224498A1 (es) Una disposicion distribuidora de un flujo de informacion
IT1149950B (it) Tramezzo perfezionato e pannelli compositi per la realizzazione
DE3576319D1 (de) Zuschnitt aus karton od. dgl. zum herstellen einer kassette.
ES1013164Y (es) Una disposicion rociadora perfeccionada para agricultura
IT8522820A0 (it) Pellicole poliolefiniche rivestite temosaldabili, aventi una bassa adesivita' alle barre saldanti.
ES1001914Y (es) Distribuidor para cinta adhesiva
IT8321294V0 (it) Distributore perfezionato per spargere sementi in genere.
ES282494Y (es) Aspersor perfeccionado para riego
ITMI922518A0 (it) Medicazione per patologie cutanee
ES251389Y (es) Boquilla perfeccionada para fumador
ES249970Y (es) Pulverizador para tratamientos agricolas
AR223306Q (es) Una estructura de capas multiples y metodo para producirla
ES254633Y (es) Nebulizador perfeccionado para tratamientos fitosanitarios