SI9210277B - Transdermalni terapevtski obliži - Google Patents

Transdermalni terapevtski obliži Download PDF

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Publication number
SI9210277B
SI9210277B SI9210277A SI9210277A SI9210277B SI 9210277 B SI9210277 B SI 9210277B SI 9210277 A SI9210277 A SI 9210277A SI 9210277 A SI9210277 A SI 9210277A SI 9210277 B SI9210277 B SI 9210277B
Authority
SI
Slovenia
Prior art keywords
pressure
sensitive adhesive
layer
drug reservoir
sections
Prior art date
Application number
SI9210277A
Other languages
English (en)
Other versions
SI9210277A (en
Inventor
Dieter Anhaeuser
Lothar Deurer
Thomas Hille
Peter Steinborn
Original Assignee
Lts Lohmann Therapie Systeme Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie Systeme Gmbh & Co.Kg filed Critical Lts Lohmann Therapie Systeme Gmbh & Co.Kg
Publication of SI9210277A publication Critical patent/SI9210277A/sl
Publication of SI9210277B publication Critical patent/SI9210277B/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/108—Flash, trim or excess removal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1084—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing of continuous or running length bonded web
    • Y10T156/1085—One web only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1089—Methods of surface bonding and/or assembly therefor of discrete laminae to single face of additional lamina
    • Y10T156/1092—All laminae planar and face to face
    • Y10T156/1093—All laminae planar and face to face with covering of discrete laminae with additional lamina
    • Y10T156/1095—Opposed laminae are running length webs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (2)

  1. -1- TRANSDERMALNI TERAPEVTSKI OBLIŽI PATENTNI ZAHTEVKI 1. Postopek za kontinuirano proizvodnjo transdermalnih terapevtskih obližev, ki izkazujejo hrbtni sloj (19, na pritisk občutljivi adhezivni sloj (6) z rezervoarjem zdravila in snemljivi zaščitni sloj, v katerem je izguba zdravila med izdelavo minimizirana in da se v lameli, ki je prisotna v obliki traku in se sestoji iz na pritisk občutljivega adhezivnega hrbtnega sloja (1) in odstranijivega zaščitnega sloja (3), vložijo posamezni četverokotni, na pritisk občutljivi adhezivni odseki (2) rezervoarja zdravila vzdolžno drug za drugim med sloje (1, 3), razmaki med temi odseki rezervoarja zdravila v vzdolžni smeri eden za drugim, označen s tem, da pri tem reže med navedenimi odseki rezervoarja (2) v vzdolžni smeri ostanejo konstantnem je njihova širina dimenzionirana tako, da navedeni hrbtni sloj (1) in navedeni snemljivi zaščitni sloj (3) štrlita preko traku na obeh straneh in da se najprvo na pritisk občutljivi adhezivni hrbtni sloj (1) reže z izsekavanjem na takšen način, da obkroža izsekovalna črta (1a) zunanje dimenzije posameznih odsekov (2) rezervoarja zdravila na znatni razdalji in da se odstrani izišli rešetkasti odpadek na pritisk občutljivega, zdravila prostega adhezivnega hrbtnega sloja (1) odstrani in da se zaščitni sloj (3) nato reže v nastale prostore med odseki (2) rezervoarja zdravila.
  2. 2. Postopek po zahtevku 1, označen s tem, da se pred aplikacijo na pritisk občutljivega adhezivnega sloja (2) z rezervoarji zdravila na na pritisk občutljivi adhezivni hrbtni sloj (1), ta stran tega na pritisk občutljivega adhezivnega sloja z rezervoarji zdravila, ki leži proti hrbtnemu sloju, prekriva z zapornim slojem (5), ki je nepropusten za dejavne snovi.
SI9210277A 1991-03-27 1992-03-18 Transdermalni terapevtski obliži SI9210277B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4110027A DE4110027C2 (de) 1991-03-27 1991-03-27 Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster
YU27792A YU48183B (sh) 1991-03-27 1992-03-18 Postupak za kontinuiranu izradu transdermalnih terapijskih flastera

Publications (2)

Publication Number Publication Date
SI9210277A SI9210277A (en) 1994-06-30
SI9210277B true SI9210277B (sl) 2000-10-31

Family

ID=6428306

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9210277A SI9210277B (sl) 1991-03-27 1992-03-18 Transdermalni terapevtski obliži

Country Status (26)

Country Link
US (1) US6315854B1 (sl)
EP (1) EP0577622B1 (sl)
JP (1) JPH0665349B2 (sl)
KR (1) KR970006100B1 (sl)
AT (1) ATE146365T1 (sl)
AU (1) AU657314B2 (sl)
CA (1) CA2106374C (sl)
CZ (1) CZ281267B6 (sl)
DE (2) DE4110027C2 (sl)
DK (1) DK0577622T3 (sl)
ES (1) ES2098500T3 (sl)
FI (1) FI107020B (sl)
GR (1) GR3022863T3 (sl)
HR (1) HRP930668B1 (sl)
HU (1) HU210845B (sl)
IE (1) IE78823B1 (sl)
IL (1) IL101189A (sl)
MY (1) MY106656A (sl)
NO (1) NO306849B1 (sl)
NZ (1) NZ242127A (sl)
PH (1) PH31285A (sl)
SI (1) SI9210277B (sl)
SK (1) SK278995B6 (sl)
WO (1) WO1992017237A1 (sl)
YU (1) YU48183B (sl)
ZA (1) ZA922190B (sl)

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
DE4229230C2 (de) * 1992-09-02 1997-01-16 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit Pentetrazol als Wirkstoff
DE19547691C1 (de) * 1995-12-20 1997-04-24 Lohmann Therapie Syst Lts Verfahren zur Herstellung transdermaler therapeutischer Pflaster (TTS)
DE19702314C2 (de) * 1997-01-23 2000-12-21 Lohmann Therapie Syst Lts Ablösbare Schutzfolie für wirkstoffhaltige, insbesondere selbstklebende Pflastersysteme
DE19736315A1 (de) * 1997-08-21 1999-02-25 Lohmann Therapie Syst Lts Wirkstoffhaltige Dochtsysteme
DE19738855C2 (de) 1997-09-05 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit haftklebender Reservoirschicht und unidirektional elastischer Rückschicht
DE19749525C1 (de) * 1997-11-08 1999-06-10 Lohmann Therapie Syst Lts Laserstrahl-Schneideverfahren zum Schneiden von Laminat zur Applikation auf die Haut und Fixiervorrichtung
GB2336310B (en) * 1998-04-14 2003-09-10 Stowic Resources Ltd Method of manufacturing transdermal patches
DE19923427A1 (de) 1999-05-21 2000-11-23 Lohmann Therapie Syst Lts Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen
DE19925338A1 (de) * 1999-06-02 2000-12-07 Lohmann Therapie Syst Lts Substratabschnitte mit erhöhter Lagerstabilität während ihrer Lagerung in Beutelverpackung, sowie Verfahren zu ihrer Herstellung
WO2002058608A1 (en) * 2000-10-23 2002-08-01 Euro-Celtique, S.A. Loratadine transdermal device and methods
GB2414397B (en) * 2004-05-26 2009-03-11 Johnson And Johnson Medical Ltd Self-irrigating wound dressing
US8608889B2 (en) * 2005-06-10 2013-12-17 3M Innovative Properties Company Method for handling adhesive laminate sections
DE102007006244B4 (de) * 2007-02-08 2012-03-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System zur Verabreichung wasserlöslicher Wirkstoffe
EP2178480B1 (de) * 2007-08-21 2010-10-27 LTS LOHMANN Therapie-Systeme AG Verfahren zum mehrspurigen konfektionieren transdermaler therapeutischer pflaster
DE102010000661A1 (de) * 2010-01-04 2011-07-07 Acino Ag, 83714 Verfahren und Vorrichtung zur Herstellung einer überlappenden Schutzfolie für ein transdermales therapeutisches System
DE102010064358A1 (de) 2010-12-29 2012-07-05 Acino Ag Transdermales Applikationssystem mit überstehender Backingfolie
EP2682113B1 (de) * 2012-07-02 2018-10-31 Luye Pharma AG Verschließen wirkstoffhaltiger Laminate
EP2818159A1 (de) * 2013-06-25 2014-12-31 LTS LOHMANN Therapie-Systeme AG Vorrichtung mit transdermalem therapeutischem System, Positionier- und Penetrationshilfe
EP2921184A1 (de) * 2014-03-19 2015-09-23 LTS LOHMANN Therapie-Systeme AG Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung
US10478346B2 (en) 2014-12-18 2019-11-19 3M Innovative Properties Company Methods of handling adhesive laminate patches
CN112402095B (zh) * 2020-11-17 2022-05-31 新领医药技术(深圳)有限公司 一种硫酸镁冷敷贴及其制备工艺
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
WO2022216977A1 (en) 2021-04-07 2022-10-13 Batelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers

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DE3910543A1 (de) * 1989-04-01 1990-10-11 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung
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Also Published As

Publication number Publication date
ES2098500T3 (es) 1997-05-01
ATE146365T1 (de) 1997-01-15
SK101193A3 (en) 1994-04-06
EP0577622B1 (de) 1996-12-18
IL101189A (en) 1995-05-26
NO933414D0 (no) 1993-09-24
DE59207727D1 (de) 1997-01-30
YU48183B (sh) 1997-07-31
JPH06501185A (ja) 1994-02-10
FI107020B (fi) 2001-05-31
CZ193293A3 (en) 1994-03-16
DK0577622T3 (da) 1997-06-16
PH31285A (en) 1998-07-06
HU9302700D0 (en) 1993-12-28
ZA922190B (en) 1992-12-30
AU1353592A (en) 1992-11-02
IE78823B1 (en) 1998-02-25
NO306849B1 (no) 2000-01-03
DE4110027C2 (de) 1996-08-29
FI934189A0 (fi) 1993-09-24
FI934189A (fi) 1993-09-24
HUT65961A (en) 1994-08-29
EP0577622A1 (de) 1994-01-12
CA2106374A1 (en) 1992-09-28
HU210845B (en) 1995-08-28
HRP930668A2 (en) 1994-10-31
HRP930668B1 (en) 2001-02-28
CZ281267B6 (cs) 1996-07-17
KR970006100B1 (ko) 1997-04-23
WO1992017237A1 (de) 1992-10-15
YU27792A (sh) 1995-01-31
GR3022863T3 (sl) 1997-06-30
MY106656A (en) 1995-07-31
SK278995B6 (sk) 1998-05-06
DE4110027A1 (de) 1992-10-01
NO933414L (no) 1993-09-24
IE920963A1 (en) 1992-10-07
NZ242127A (en) 1994-04-27
AU657314B2 (en) 1995-03-09
US6315854B1 (en) 2001-11-13
SI9210277A (en) 1994-06-30
CA2106374C (en) 1997-03-18
JPH0665349B2 (ja) 1994-08-24

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