YU47956B - Postupak za izradu transdermalnog terapijskog sistema sa buprenorphinom kao aktivnim sastojkom - Google Patents

Postupak za izradu transdermalnog terapijskog sistema sa buprenorphinom kao aktivnim sastojkom

Info

Publication number
YU47956B
YU47956B YU226090A YU226090A YU47956B YU 47956 B YU47956 B YU 47956B YU 226090 A YU226090 A YU 226090A YU 226090 A YU226090 A YU 226090A YU 47956 B YU47956 B YU 47956B
Authority
YU
Yugoslavia
Prior art keywords
buprenorphine
weight
procedure
making
active ingredient
Prior art date
Application number
YU226090A
Other languages
English (en)
Other versions
YU226090A (sh
Inventor
T. Hille
L. Deurer
H.R. Hoffmann
Original Assignee
Lts. Lohmann Therapie-Systeme Gmbh. Co.Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6394373&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU47956(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lts. Lohmann Therapie-Systeme Gmbh. Co.Kg. filed Critical Lts. Lohmann Therapie-Systeme Gmbh. Co.Kg.
Priority to SI9012260A priority Critical patent/SI9012260B/sl
Publication of YU226090A publication Critical patent/YU226090A/sh
Priority to HRP-2260/90A priority patent/HRP930675B1/xx
Publication of YU47956B publication Critical patent/YU47956B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Laminated Bodies (AREA)

Abstract

Postupak za izradu transdermalnog terapijskog sistema za davanje Buprenorphin-a kroz kožu koji se sastoji iz zadnjeg sloja koji je nepropusan za aktivnu materiju, sloja rezervoara koji se lepi prianjajući i u datom slučaju zaštitnog sloja koji može ponovo da se odvoji, naznačen time, što se za izradu sloja rezervoara homogenizuje smeša iz 20 do 90 mas.-% polimernog materijla, 0,1 do 20 mas.-% omekšivača, 0,1 do 20 mas.-% buprenorphin baze ili jedne od njegovih farmaceutski prihavtljivih soli i 0,1 do 30 mas.-% rastvarača za bazu aktivne materije uz eventualni dodatak lako isparljivih rastvarača i nanese na zadnji sloj ili zaštitni sloj, posle čega se odstranjuju lako isparljivi rastvarači. Prijava sadrži još 10 zavisnih zahteva.
YU226090A 1989-11-29 1990-11-27 Postupak za izradu transdermalnog terapijskog sistema sa buprenorphinom kao aktivnim sastojkom YU47956B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012260A SI9012260B (sl) 1989-11-29 1990-11-27 Postopek za izdelavo transdermalnih terapevtskih sistemov z buprenorfinom kot dejavno sestavino
HRP-2260/90A HRP930675B1 (en) 1989-11-29 1993-04-01 Process for the preparation of transdermal therapeutic system with buprenorphine as an active substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3939376A DE3939376C1 (sh) 1989-11-29 1989-11-29

Publications (2)

Publication Number Publication Date
YU226090A YU226090A (sh) 1992-12-21
YU47956B true YU47956B (sh) 1996-07-24

Family

ID=6394373

Family Applications (1)

Application Number Title Priority Date Filing Date
YU226090A YU47956B (sh) 1989-11-29 1990-11-27 Postupak za izradu transdermalnog terapijskog sistema sa buprenorphinom kao aktivnim sastojkom

Country Status (25)

Country Link
EP (1) EP0430019B1 (sh)
JP (1) JPH0818984B2 (sh)
KR (1) KR950015061B1 (sh)
AT (1) ATE135205T1 (sh)
AU (1) AU632182B2 (sh)
CA (1) CA2030178C (sh)
CZ (1) CZ282557B6 (sh)
DE (2) DE3939376C1 (sh)
DK (1) DK0430019T3 (sh)
ES (1) ES2086353T3 (sh)
FI (1) FI100379B (sh)
GR (1) GR3020177T3 (sh)
HR (1) HRP930675B1 (sh)
HU (1) HU206266B (sh)
IE (1) IE73247B1 (sh)
IL (1) IL96243A (sh)
MY (1) MY105347A (sh)
NO (1) NO303107B1 (sh)
NZ (1) NZ236191A (sh)
PL (1) PL165396B1 (sh)
PT (1) PT96028B (sh)
SI (1) SI9012260B (sh)
SK (1) SK279687B6 (sh)
YU (1) YU47956B (sh)
ZA (1) ZA909544B (sh)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
US6344211B1 (en) 1994-12-24 2002-02-05 Lts Lohmann Therapie-Systeme Gmbh Transdermal absorption of active substances from subcooled melts
DE4446600A1 (de) * 1994-12-24 1996-06-27 Lohmann Therapie Syst Lts Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen
JPH1036265A (ja) * 1996-07-19 1998-02-10 Nitto Denko Corp ブプレノルフィン経皮吸収製剤
DE19705138A1 (de) * 1997-02-11 1998-08-13 Lohmann Therapie Syst Lts Dehnbares transdermales therapeutisches System
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
DE19738855C2 (de) 1997-09-05 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit haftklebender Reservoirschicht und unidirektional elastischer Rückschicht
DE19828273B4 (de) * 1998-06-25 2005-02-24 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren
DE19850517B4 (de) 1998-11-03 2004-02-12 Lts Lohmann Therapie-Systeme Ag Verwendung eines wirkstoffhaltigen transdermalen therapeutischen Systems in einer Kombinationsbehandlung mit und ohne Ultraschall
DE19901085C2 (de) * 1999-01-14 2003-12-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit einer selbstklebenden Matrix, enthaltend organische Säure-Additionssalze von Alkaloiden des Morphin- bzw. Morphinantyps
DE19923551A1 (de) * 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
DE10056012A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Flexible Barrierefolie für ein Trägermaterial für medizinische Zwecke
DE10056014A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Mehrschichtige Trägerkonstruktion für wirkstofhaltige Pflastersyteme
JP4194277B2 (ja) 2002-01-25 2008-12-10 久光製薬株式会社 架橋ポリマーを主成分とする粘着性成形体の製造方法
DE10237057A1 (de) * 2002-08-09 2004-03-25 Grünenthal GmbH Opioid-Rezeptor-Antagonisten in Pflasterformulierungen
AU2003283055A1 (en) * 2002-08-09 2004-02-25 Grunenthal Gmbh Opioid-receptor antagonists in transdermal systems having buprenorphine
CN102772357B (zh) 2003-03-31 2014-12-31 泰坦医药品公司 用于持续释放多巴胺受体激动剂的可植入聚合物装置
DK1646328T3 (da) 2003-07-25 2008-02-04 Euro Celtique Sa Behandling af afhængighedsophör
DE102004009903A1 (de) 2004-02-26 2005-09-22 Grünenthal GmbH Pflaster mit reduzierter Hautirritation
EP1743638A1 (en) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
DE102006057083A1 (de) 2005-12-05 2007-06-28 Lg Electronics Inc. Beleuchtungsvorrichtung für einen Kühlschrank
DE102006054731B4 (de) 2006-11-21 2013-02-28 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie
DK2640389T3 (en) * 2010-11-17 2015-03-09 Hexal Ag Transdermal therapeutic system comprising buprenorphine
DE102011076653A1 (de) 2011-05-27 2012-11-29 Acino Ag Transdermales therapeutisches System enthaltend Buprenorphin und eine alpha-Hydroxysäure
TW201338813A (zh) 2011-12-12 2013-10-01 Lohmann Therapie Syst Lts 經皮遞送系統
DE102012000369A1 (de) 2012-01-11 2013-07-11 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermales therapeutisches System mit Cholinesterase-Hemmer
BR112015029920A2 (pt) 2013-06-04 2017-07-25 Lts Lohmann Therapie Systeme Ag sistema de administração transdérmica
DE102014013448A1 (de) 2014-09-16 2016-03-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermales Therapeutisches System umfassend Buprenorphin
US9656441B2 (en) 2015-01-08 2017-05-23 Alfred E. Tiefenbacher ( Gmbh & Co. Kg) Transdermal patch
EP3067050A1 (en) 2015-03-13 2016-09-14 Acino AG Transdermal therapeutic system with an overtape comprising two adhesive layers
CN109045341A (zh) * 2018-05-07 2018-12-21 武汉兴嘉业堂医疗科技发展有限公司 一种活血止痛压敏胶及其制备方法、应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464378A (en) * 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
JPS60123417A (ja) * 1983-12-07 1985-07-02 Nitto Electric Ind Co Ltd 薬物投与部材
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4806341A (en) * 1985-02-25 1989-02-21 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration
DE3634016A1 (de) * 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung
JPS632533A (ja) * 1986-06-23 1988-01-07 Yamakawa Sangyo Kk 精密鋳造用鋳物砂
CH672888A5 (sh) * 1986-11-07 1990-01-15 Mepha Ag
DE3862405D1 (de) * 1987-03-09 1991-05-23 Alza Corp Zusammensetzung zur vorbeugung einer kontaktallergie durch gleichzeitiges verabreichen eines kortikosteroids mit einem sensiblisierenden arzneistoff.
JPH02503672A (ja) * 1987-06-01 1990-11-01 ワーナー‐ランバート・コンパニー 水性の系における浸透促進剤としての脂肪酸およびその短鎖エステル
DE3843237A1 (de) * 1988-12-22 1990-07-05 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit einem antiadipositum als aktivem bestandteil

Also Published As

Publication number Publication date
IL96243A (en) 1994-11-28
HU206266B (en) 1992-10-28
IL96243A0 (en) 1991-08-16
HUT55643A (en) 1991-06-28
DK0430019T3 (da) 1996-07-22
HRP930675B1 (en) 1999-10-31
CZ282557B6 (cs) 1997-08-13
PL287989A1 (en) 1991-09-09
FI100379B (fi) 1997-11-28
JPH03193732A (ja) 1991-08-23
PL165396B1 (en) 1994-12-30
PT96028A (pt) 1991-09-13
DE3939376C1 (sh) 1991-05-08
EP0430019A3 (en) 1991-09-18
DE59010192D1 (de) 1996-04-18
CA2030178A1 (en) 1991-05-30
FI905892A0 (fi) 1990-11-29
IE904290A1 (en) 1991-06-05
ES2086353T3 (es) 1996-07-01
JPH0818984B2 (ja) 1996-02-28
FI905892A (fi) 1991-05-30
YU226090A (sh) 1992-12-21
ZA909544B (en) 1992-08-26
NZ236191A (en) 1993-05-26
EP0430019A2 (de) 1991-06-05
NO303107B1 (no) 1998-06-02
KR910009249A (ko) 1991-06-28
AU6569990A (en) 1991-06-06
PT96028B (pt) 1998-02-27
EP0430019B1 (de) 1996-03-13
SK279687B6 (sk) 1999-02-11
SI9012260B (sl) 1998-06-30
IE73247B1 (en) 1997-05-21
NO905103D0 (no) 1990-11-26
SI9012260A (en) 1997-10-31
HRP930675A2 (en) 1994-10-31
NO905103L (no) 1991-05-30
MY105347A (en) 1994-09-30
ATE135205T1 (de) 1996-03-15
AU632182B2 (en) 1992-12-17
CS9005598A2 (en) 1991-12-17
CA2030178C (en) 1995-08-15
KR950015061B1 (ko) 1995-12-21
GR3020177T3 (en) 1996-09-30

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