YU46183B - Postupak za dobijanje peptida - Google Patents
Postupak za dobijanje peptidaInfo
- Publication number
- YU46183B YU46183B YU200586A YU200586A YU46183B YU 46183 B YU46183 B YU 46183B YU 200586 A YU200586 A YU 200586A YU 200586 A YU200586 A YU 200586A YU 46183 B YU46183 B YU 46183B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- carbon atoms
- alkyl
- formula
- hydrogen
- cycloalkylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
cikloalkil sa 4 do 7 atoma ugljenika ili cikloalkilmetil sa 6 do 8 atoma ugljenika; R2 je vodonik ili alkil sa 1-3 atoma ugljenika; i R3 je hidroksi ili ostatak amino kiseline formule gde je X vodonik, alkil C1-C2 ili hidroksimetil i n je ceo broj od 0-4; i R4 i R5 su svaki nezavisno vodonik, alkil C1-C6, cikloalkilmetil sa 6 do 8 atoma ugljenika ili benzil, naznacen time, sto se dehidrativno spaja jedinjenje formule gde su R1 i R2 kao sto je prethodno definisano sa jedinjenjem formule u reakciono inertnom rastvoru, kao sto je metilenhlorid, na 25-100 °C, gde funkcionalne grupe koje nisu obuhvacene reakcijom mogu da se blokiraju i gde su X, n i R5 kao sto je ranije definisano, posle cega se izvodi opciona faza selektivnog uklanjanja blokirajucih grupa i, po potrebi, dobijanje farmaceutski prihvatljivih baznih soli proizvoda. Postupak za dobijanje jedinjenja formule gde je R1 alkil sa 2 do 10 atoma ugljenik, sikloalkil sa 4 do 7 atoma ugljenika ili cikloalkilmetil sa 6 do 8 atoma ugljenika; R2 je vodonik ili alkil sa 1-3 atoma ugljenika; i R3 je hidroksi ili ostatak amino kiseline formule gde je X vodonik, alkil C1-C2 ili hidroksimetil i n je ceo broj od 0-4; i R4 i R5 su svako nezavisno vodonik, alkil C1-C6, cikloalkilmetil sa 6 do 8 atoma ugljenika ili benzil, naznaceno time, sto se aciluje jedinjenje formule gde su R2 i R5 kao sto je prethodno definisano, sa jedinjenjem formule R1CO-Hal u reakciono inertnom rastvoru, kao sto je metilenhlorid, koji sadrzi tercijalni amin, na 25° C, gde funkcionalne grupe koje nisu obuh-vacene reakcijom mogu da se blokiraju i gde su R1 kao sto je ranije definisano, Hal predstavlja halogen, posle cega se izvodi opciona faza selektivnog uklanjanja blokirajucih grupa i, po potrebi, dobijanje farmaceutski prihvatljivih baznih soli proizvoda. -Prijava sadrzi jos 2 zavisna zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8502351 | 1985-11-25 | ||
| US06/900,934 US4767743A (en) | 1986-08-27 | 1986-08-27 | Peptide immunostimulants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU200586A YU200586A (en) | 1988-06-30 |
| YU46183B true YU46183B (sh) | 1993-05-28 |
Family
ID=26772151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU200586A YU46183B (sh) | 1985-11-25 | 1986-11-24 | Postupak za dobijanje peptida |
Country Status (12)
| Country | Link |
|---|---|
| KR (1) | KR900004648B1 (sh) |
| CN (1) | CN1017436B (sh) |
| AU (1) | AU579501B2 (sh) |
| CA (1) | CA1295784C (sh) |
| DK (1) | DK170345B1 (sh) |
| FI (1) | FI86858C (sh) |
| NO (1) | NO170422C (sh) |
| PH (1) | PH22258A (sh) |
| PL (2) | PL150055B1 (sh) |
| PT (1) | PT83796B (sh) |
| SU (1) | SU1560058A3 (sh) |
| YU (1) | YU46183B (sh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851388A (en) * | 1986-01-23 | 1989-07-25 | Pfizer Inc. | Heptanoyl-glu-asp-ala-amino acid immunostimulants |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4565653A (en) * | 1984-03-30 | 1986-01-21 | Pfizer Inc. | Acyltripeptide immunostimulants |
| WO1988001612A1 (en) * | 1986-08-27 | 1988-03-10 | Pfizer Inc. | Processes and intermediates for n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine |
-
1986
- 1986-11-21 CA CA000523519A patent/CA1295784C/en not_active Expired - Fee Related
- 1986-11-24 FI FI864772A patent/FI86858C/fi not_active IP Right Cessation
- 1986-11-24 KR KR1019860009903A patent/KR900004648B1/ko not_active IP Right Cessation
- 1986-11-24 NO NO864689A patent/NO170422C/no unknown
- 1986-11-24 PL PL1986262563A patent/PL150055B1/pl unknown
- 1986-11-24 PL PL1986268313A patent/PL150129B1/pl unknown
- 1986-11-24 DK DK561986A patent/DK170345B1/da not_active IP Right Cessation
- 1986-11-24 AU AU65618/86A patent/AU579501B2/en not_active Ceased
- 1986-11-24 PT PT83796A patent/PT83796B/pt not_active IP Right Cessation
- 1986-11-24 CN CN86107931A patent/CN1017436B/zh not_active Expired
- 1986-11-24 PH PH34518A patent/PH22258A/en unknown
- 1986-11-24 YU YU200586A patent/YU46183B/sh unknown
-
1987
- 1987-11-17 SU SU874203671A patent/SU1560058A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| KR870005012A (ko) | 1987-06-04 |
| DK170345B1 (da) | 1995-08-07 |
| FI86858C (fi) | 1992-10-26 |
| SU1560058A3 (ru) | 1990-04-23 |
| NO170422C (no) | 1992-10-14 |
| CA1295784C (en) | 1992-02-11 |
| PL262563A1 (en) | 1988-04-28 |
| FI864772A0 (fi) | 1986-11-24 |
| AU579501B2 (en) | 1988-11-24 |
| PL150055B1 (en) | 1990-04-30 |
| CN86107931A (zh) | 1987-07-01 |
| YU200586A (en) | 1988-06-30 |
| PH22258A (en) | 1988-07-01 |
| PT83796B (pt) | 1989-06-30 |
| DK561986D0 (da) | 1986-11-24 |
| CN1017436B (zh) | 1992-07-15 |
| KR900004648B1 (ko) | 1990-07-02 |
| FI86858B (fi) | 1992-07-15 |
| NO864689D0 (no) | 1986-11-24 |
| FI864772A (fi) | 1987-05-26 |
| PL268313A1 (en) | 1988-07-07 |
| AU6561886A (en) | 1987-05-28 |
| DK561986A (da) | 1987-08-12 |
| NO170422B (no) | 1992-07-06 |
| PT83796A (en) | 1986-12-01 |
| PL150129B1 (en) | 1990-04-30 |
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