YU46183B - PROCEDURE FOR OBTAINING PEPTIDES - Google Patents
PROCEDURE FOR OBTAINING PEPTIDESInfo
- Publication number
- YU46183B YU46183B YU200586A YU200586A YU46183B YU 46183 B YU46183 B YU 46183B YU 200586 A YU200586 A YU 200586A YU 200586 A YU200586 A YU 200586A YU 46183 B YU46183 B YU 46183B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- carbon atoms
- alkyl
- formula
- hydrogen
- cycloalkylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
cikloalkil sa 4 do 7 atoma ugljenika ili cikloalkilmetil sa 6 do 8 atoma ugljenika; R2 je vodonik ili alkil sa 1-3 atoma ugljenika; i R3 je hidroksi ili ostatak amino kiseline formule gde je X vodonik, alkil C1-C2 ili hidroksimetil i n je ceo broj od 0-4; i R4 i R5 su svaki nezavisno vodonik, alkil C1-C6, cikloalkilmetil sa 6 do 8 atoma ugljenika ili benzil, naznačen time, što se dehidrativno spaja jedinjenje formule gde su R1 i R2 kao što je prethodno definisano sa jedinjenjem formule u reakciono inertnom rastvoru, kao što je metilenhlorid, na 25-100 °C, gde funkcionalne grupe koje nisu obuhvaćene reakcijom mogu da se blokiraju i gde su X, n i R5 kao što je ranije definisano, posle čega se izvodi opciona faza selektivnog uklanjanja blokirajućih grupa i, po potrebi, dobijanje farmaceutski prihvatljivih baznih soli proizvoda. Postupak za dobijanje jedinjenja formule gde je R1 alkil sa 2 do 10 atoma ugljenik, sikloalkil sa 4 do 7 atoma ugljenika ili cikloalkilmetil sa 6 do 8 atoma ugljenika; R2 je vodonik ili alkil sa 1-3 atoma ugljenika; i R3 je hidroksi ili ostatak amino kiseline formule gde je X vodonik, alkil C1-C2 ili hidroksimetil i n je ceo broj od 0-4; i R4 i R5 su svako nezavisno vodonik, alkil C1-C6, cikloalkilmetil sa 6 do 8 atoma ugljenika ili benzil, naznačeno time, što se aciluje jedinjenje formule gde su R2 i R5 kao što je prethodno definisano, sa jedinjenjem formule R1CO-Hal u reakciono inertnom rastvoru, kao što je metilenhlorid, koji sadrži tercijalni amin, na 25° C, gde funkcionalne grupe koje nisu obuh-vaćene reakcijom mogu da se blokiraju i gde su R1 kao što je ranije definisano, Hal predstavlja halogen, posle čega se izvodi opciona faza selektivnog uklanjanja blokirajućih grupa i, po potrebi, dobijanje farmaceutski prihvatljivih baznih soli proizvoda. -Prijava sadrži još 2 zavisna zahteva.cycloalkyl of 4 to 7 carbon atoms or cycloalkylmethyl of 6 to 8 carbon atoms; R 2 is hydrogen or alkyl of 1-3 carbon atoms; and R3 is hydroxy or an amino acid residue of the formula where X is hydrogen, C1-C2 alkyl or hydroxymethyl and n is an integer from 0-4; and R 4 and R 5 are each independently hydrogen, C 1 -C 6 alkyl, cycloalkylmethyl having 6 to 8 carbon atoms, or benzyl, wherein a compound of the formula wherein R 1 and R 2 are as defined above is dehydratively coupled to a compound of the formula in a reaction inert solution , such as methylene chloride, at 25-100 °C, where unreacted functional groups can be blocked and where X, n and R 5 are as previously defined, followed by an optional step of selective removal of blocking groups and, by if necessary, obtaining pharmaceutically acceptable base salts of the product. Process for obtaining compounds of the formula where R1 is alkyl with 2 to 10 carbon atoms, cycloalkyl with 4 to 7 carbon atoms or cycloalkylmethyl with 6 to 8 carbon atoms; R 2 is hydrogen or alkyl of 1-3 carbon atoms; and R3 is hydroxy or an amino acid residue of the formula where X is hydrogen, C1-C2 alkyl or hydroxymethyl and n is an integer from 0-4; and R 4 and R 5 are each independently hydrogen, C 1 -C 6 alkyl, cycloalkylmethyl of 6 to 8 carbon atoms, or benzyl, indicated by acylating a compound of the formula wherein R 2 and R 5 are as defined above, with a compound of the formula R 1 CO-Hal in to a reactively inert solution, such as methylene chloride, containing a tertiary amine, at 25°C, where functional groups not involved in the reaction can be blocked and where R1 is as defined earlier, Hal represents halogen, after which optional step of selective removal of blocking groups and, if necessary, obtaining pharmaceutically acceptable base salts of the product. - The application contains 2 more dependent requests.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8502351 | 1985-11-25 | ||
US06/900,934 US4767743A (en) | 1986-08-27 | 1986-08-27 | Peptide immunostimulants |
Publications (2)
Publication Number | Publication Date |
---|---|
YU200586A YU200586A (en) | 1988-06-30 |
YU46183B true YU46183B (en) | 1993-05-28 |
Family
ID=26772151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU200586A YU46183B (en) | 1985-11-25 | 1986-11-24 | PROCEDURE FOR OBTAINING PEPTIDES |
Country Status (12)
Country | Link |
---|---|
KR (1) | KR900004648B1 (en) |
CN (1) | CN1017436B (en) |
AU (1) | AU579501B2 (en) |
CA (1) | CA1295784C (en) |
DK (1) | DK170345B1 (en) |
FI (1) | FI86858C (en) |
NO (1) | NO170422C (en) |
PH (1) | PH22258A (en) |
PL (2) | PL150129B1 (en) |
PT (1) | PT83796B (en) |
SU (1) | SU1560058A3 (en) |
YU (1) | YU46183B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4851388A (en) * | 1986-01-23 | 1989-07-25 | Pfizer Inc. | Heptanoyl-glu-asp-ala-amino acid immunostimulants |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4565653A (en) * | 1984-03-30 | 1986-01-21 | Pfizer Inc. | Acyltripeptide immunostimulants |
WO1988001612A1 (en) * | 1986-08-27 | 1988-03-10 | Pfizer Inc. | Processes and intermediates for n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine |
-
1986
- 1986-11-21 CA CA000523519A patent/CA1295784C/en not_active Expired - Fee Related
- 1986-11-24 KR KR1019860009903A patent/KR900004648B1/en not_active IP Right Cessation
- 1986-11-24 DK DK561986A patent/DK170345B1/en not_active IP Right Cessation
- 1986-11-24 PL PL1986268313A patent/PL150129B1/en unknown
- 1986-11-24 PT PT83796A patent/PT83796B/en not_active IP Right Cessation
- 1986-11-24 YU YU200586A patent/YU46183B/en unknown
- 1986-11-24 CN CN86107931A patent/CN1017436B/en not_active Expired
- 1986-11-24 PL PL1986262563A patent/PL150055B1/en unknown
- 1986-11-24 NO NO864689A patent/NO170422C/en unknown
- 1986-11-24 AU AU65618/86A patent/AU579501B2/en not_active Ceased
- 1986-11-24 FI FI864772A patent/FI86858C/en not_active IP Right Cessation
- 1986-11-24 PH PH34518A patent/PH22258A/en unknown
-
1987
- 1987-11-17 SU SU874203671A patent/SU1560058A3/en active
Also Published As
Publication number | Publication date |
---|---|
YU200586A (en) | 1988-06-30 |
CN1017436B (en) | 1992-07-15 |
CA1295784C (en) | 1992-02-11 |
AU6561886A (en) | 1987-05-28 |
FI864772A (en) | 1987-05-26 |
FI864772A0 (en) | 1986-11-24 |
PL268313A1 (en) | 1988-07-07 |
DK561986D0 (en) | 1986-11-24 |
KR870005012A (en) | 1987-06-04 |
DK561986A (en) | 1987-08-12 |
PL262563A1 (en) | 1988-04-28 |
AU579501B2 (en) | 1988-11-24 |
PL150055B1 (en) | 1990-04-30 |
PT83796B (en) | 1989-06-30 |
FI86858C (en) | 1992-10-26 |
PH22258A (en) | 1988-07-01 |
DK170345B1 (en) | 1995-08-07 |
PL150129B1 (en) | 1990-04-30 |
PT83796A (en) | 1986-12-01 |
NO170422C (en) | 1992-10-14 |
FI86858B (en) | 1992-07-15 |
SU1560058A3 (en) | 1990-04-23 |
KR900004648B1 (en) | 1990-07-02 |
NO864689D0 (en) | 1986-11-24 |
NO170422B (en) | 1992-07-06 |
CN86107931A (en) | 1987-07-01 |
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