YU43156B - Process for separating new derivatives of 5-(2-furoyl)-5-(2-thenoyl)-5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)-pyrrol-l-carboxylic aci - Google Patents

Process for separating new derivatives of 5-(2-furoyl)-5-(2-thenoyl)-5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)-pyrrol-l-carboxylic aci

Info

Publication number
YU43156B
YU43156B YU475/83A YU47583A YU43156B YU 43156 B YU43156 B YU 43156B YU 475/83 A YU475/83 A YU 475/83A YU 47583 A YU47583 A YU 47583A YU 43156 B YU43156 B YU 43156B
Authority
YU
Yugoslavia
Prior art keywords
thenoyl
furoyl
pyrrol
pyrrolo
dihydro
Prior art date
Application number
YU475/83A
Other languages
English (en)
Other versions
YU47583A (en
Inventor
J M Muschowski
A F Kluge
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/771,283 external-priority patent/US4087539A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of YU47583A publication Critical patent/YU47583A/xx
Publication of YU43156B publication Critical patent/YU43156B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
YU475/83A 1976-07-14 1983-02-28 Process for separating new derivatives of 5-(2-furoyl)-5-(2-thenoyl)-5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)-pyrrol-l-carboxylic aci YU43156B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70485776A 1976-07-14 1976-07-14
US05/771,283 US4087539A (en) 1976-07-14 1977-02-23 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (2)

Publication Number Publication Date
YU47583A YU47583A (en) 1984-06-30
YU43156B true YU43156B (en) 1989-04-30

Family

ID=27107392

Family Applications (2)

Application Number Title Priority Date Filing Date
YU475/83A YU43156B (en) 1976-07-14 1983-02-28 Process for separating new derivatives of 5-(2-furoyl)-5-(2-thenoyl)-5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)-pyrrol-l-carboxylic aci
YU476/83A YU43157B (en) 1976-07-14 1983-02-28 Process for the recemization of (d)-acid isomers of new derivatives of 5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU476/83A YU43157B (en) 1976-07-14 1983-02-28 Process for the recemization of (d)-acid isomers of new derivatives of 5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo

Country Status (26)

Country Link
JP (1) JPS539789A (cs)
AR (1) AR218631A1 (cs)
AU (1) AU513385B2 (cs)
CA (1) CA1100140A (cs)
CH (2) CH651045A5 (cs)
CS (1) CS208724B2 (cs)
DE (1) DE2731662A1 (cs)
DK (1) DK152652C (cs)
ES (2) ES460705A1 (cs)
FI (1) FI63407C (cs)
FR (1) FR2361396A1 (cs)
GB (1) GB1554076A (cs)
GR (1) GR61607B (cs)
HK (1) HK17581A (cs)
IE (1) IE45302B1 (cs)
IL (1) IL52492A (cs)
IT (1) IT1117314B (cs)
MY (1) MY8100371A (cs)
NL (1) NL7707652A (cs)
NO (1) NO147563C (cs)
NZ (1) NZ184611A (cs)
PL (1) PL111408B1 (cs)
PT (1) PT66779B (cs)
SE (1) SE434644B (cs)
SU (2) SU664566A3 (cs)
YU (2) YU43156B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds

Also Published As

Publication number Publication date
IE45302L (en) 1978-01-14
JPS6254110B2 (cs) 1987-11-13
YU47683A (en) 1984-04-30
IL52492A0 (en) 1977-10-31
CH651045A5 (en) 1985-08-30
SE7708142L (sv) 1978-01-15
ES460705A1 (es) 1979-10-01
FI63407C (fi) 1983-06-10
NZ184611A (en) 1979-03-28
AU513385B2 (en) 1980-11-27
AR218631A1 (es) 1980-06-30
DK152652C (da) 1988-09-12
NO147563B (no) 1983-01-24
DE2731662A1 (de) 1978-01-19
CA1100140A (en) 1981-04-28
GB1554076A (en) 1979-10-17
YU47583A (en) 1984-06-30
FR2361396B1 (cs) 1981-11-27
FI772154A7 (cs) 1978-01-15
DK152652B (da) 1988-04-05
CS208724B2 (en) 1981-09-15
AU2697677A (en) 1979-01-18
ES470213A1 (es) 1979-09-16
SU664566A3 (ru) 1979-05-25
NO772493L (no) 1978-01-17
MY8100371A (en) 1981-12-31
FR2361396A1 (fr) 1978-03-10
JPS539789A (en) 1978-01-28
SU793400A3 (ru) 1980-12-30
IT1117314B (it) 1986-02-17
HK17581A (en) 1981-05-08
IE45302B1 (en) 1982-07-28
PL111408B1 (en) 1980-08-30
NO147563C (no) 1983-05-18
FI63407B (fi) 1983-02-28
YU43157B (en) 1989-04-30
IL52492A (en) 1981-06-29
SE434644B (sv) 1984-08-06
PT66779A (fr) 1977-08-01
CH644861A5 (en) 1984-08-31
PT66779B (fr) 1978-12-18
DE2731662C2 (cs) 1989-11-09
NL7707652A (nl) 1978-01-17
DK307677A (da) 1978-01-15
PL199602A1 (pl) 1979-01-29
GR61607B (en) 1978-12-02

Similar Documents

Publication Publication Date Title
ZA774239B (en) 5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylic acid derivatives and process for the production thereof
YU44212B (en) PROCESS FOR OBTAINING DERIVATIVES OF 3-(1H-TETRAZOL-5-YL)-(4H-PYRIDO)(1,2-a)-PYRIMIDINE-4-ONES
BE865247A (fr) Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)-pyrrole-1-carboxyliques et leur procede de preparation
YU43156B (en) Process for separating new derivatives of 5-(2-furoyl)-5-(2-thenoyl)-5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)-pyrrol-l-carboxylic aci
AU3400478A (en) Derivatives of alpha-(6,carboxyhexyl) furfuryl alcohol
ZA876182B (en) 2.3-dihydrofuran derivatives,process for preparing them,and their use as an intermediate for the preparation of tetrahydrofuran derivatives
FR2313386A1 (fr) Procede de preparation de 1-((5-(4-hydroxy-2h-1,2-benzothiazin-3-yl)-1,2,4-oxadiazo 3-yl) methyl)ethanone s,s-dioxyde
YU5880A (en) Process for obtaining 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piperazinyl)-quinazoline chlorohydrate of an antihypertensive effect
DK152655C (da) Analogifremgangsmaade til fremstilling af (dl)- eller (l)-5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- eller 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-carboxylsyrederivater
JPS5350196A (en) Novel 4hhpyrido *2*33d**1*3* oxazinee44one derivatives
NZ181819A (en) 5-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazoles
SU615069A1 (ru) Способ получени производных 5(1",2",4"-триазол-,1"-ил)-1,2,4триазола
NL184681C (nl) Werkwijze voor het bereiden van zuiver 3-methoxy-4-(4'-aminobenzeensulfonamido)-1,2,5-thiadiazool.
IL49957A0 (en) 5-(substituted sulfamoyl)-1,3,4-thiadiazol-2-yl ureas
JPS53137931A (en) Novel cyclic sestaterpenes
SE435284B (sv) Forfarande for framstellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinoazolin
DK426778A (da) Fremgans fremgangsmaade til fremstilling af 7-(d(-)-alfa-(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-alfa(4-hydroxyphenyl)acetamido)-3-(5-(1-methyl-1,2,3,4-tetrazolyl)-thiomethyl)-delta3-cephemt -4-carboxylsyre eller farmaceutisk acceptable salte deraf sam
IL54642A (en) 4(5-(benzoyl or thenoyl)pyrrol 2-yl)butanol or butanone derivatives,their preparation and pharmaceutical compositions containing them
JPS53100747A (en) Detection/process method for data state change
JPS5321169A (en) Novel lactone derivatives
JPS51122066A (en) Process for preparation of heterocyclic compounds
NO882770D0 (no) Aminopropanolderivater av 3-(2-hydroksyfenyl)-1-propanforbindelser, samt fremgangsmaate for fremstilling derav.
JPS5248693A (en) Synthesis of noncyclic c-nucleosides
NO870242D0 (no) Fremgangsmaate for aa forhindre spaltning av silisiumkarbidartikler under sintring.
JPS5239640A (en) Process for preparation of 1,2- propanediol derivatives