YU42857B - Process for obtaining antiulceral 2-guanidino-4-(2-subst.amino-4-imidazolyl)-thiazoles - Google Patents

Process for obtaining antiulceral 2-guanidino-4-(2-subst.amino-4-imidazolyl)-thiazoles

Info

Publication number
YU42857B
YU42857B YU996/83A YU99683A YU42857B YU 42857 B YU42857 B YU 42857B YU 996/83 A YU996/83 A YU 996/83A YU 99683 A YU99683 A YU 99683A YU 42857 B YU42857 B YU 42857B
Authority
YU
Yugoslavia
Prior art keywords
thiazoles
guanidino
imidazolyl
amino
antiulceral
Prior art date
Application number
YU996/83A
Other languages
English (en)
Other versions
YU99683A (en
Inventor
J L Lamattina
C A Lipinski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of YU99683A publication Critical patent/YU99683A/xx
Publication of YU42857B publication Critical patent/YU42857B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88Nitrogen atoms, e.g. allantoin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
YU996/83A 1982-05-10 1983-05-05 Process for obtaining antiulceral 2-guanidino-4-(2-subst.amino-4-imidazolyl)-thiazoles YU42857B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/376,486 US4435396A (en) 1982-05-10 1982-05-10 Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor

Publications (2)

Publication Number Publication Date
YU99683A YU99683A (en) 1986-02-28
YU42857B true YU42857B (en) 1988-12-31

Family

ID=23485203

Family Applications (1)

Application Number Title Priority Date Filing Date
YU996/83A YU42857B (en) 1982-05-10 1983-05-05 Process for obtaining antiulceral 2-guanidino-4-(2-subst.amino-4-imidazolyl)-thiazoles

Country Status (26)

Country Link
US (1) US4435396A (es)
EP (1) EP0094191B1 (es)
JP (1) JPS58206588A (es)
KR (1) KR860000931B1 (es)
AT (1) ATE33649T1 (es)
AU (2) AU539244B2 (es)
CA (1) CA1201120A (es)
CS (1) CS252461B2 (es)
DD (1) DD209828A5 (es)
DE (1) DE3376322D1 (es)
DK (1) DK163829B (es)
EG (1) EG17029A (es)
ES (1) ES522223A0 (es)
FI (1) FI78481C (es)
GR (1) GR79279B (es)
GT (1) GT198302123A (es)
HU (2) HU190899B (es)
IE (1) IE55229B1 (es)
IL (1) IL68630A (es)
NO (1) NO159932C (es)
NZ (1) NZ204158A (es)
PL (1) PL141199B1 (es)
PT (1) PT76662B (es)
SU (1) SU1195907A3 (es)
YU (1) YU42857B (es)
ZA (1) ZA833286B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554276A (en) * 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
US4673677A (en) * 1983-10-03 1987-06-16 Pfizer Inc. Method for treatment of gastrointestinal disorders
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4636498A (en) * 1984-10-11 1987-01-13 Pfizer Inc. Formulation of antiinflammatory drugs
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
WO1986003203A1 (en) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
ES2031514T3 (es) * 1986-08-29 1992-12-16 Pfizer Inc. 2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas.
DE3750023T2 (de) * 1986-10-29 1994-09-29 Pfizer Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat.
CA2165344A1 (en) * 1993-06-15 1994-12-22 Peter C. Canning Immune stimulants in bacterial infections
KR101406433B1 (ko) 2008-09-22 2014-06-13 카이맨 케미칼 컴파니 인코포레이티드 H-pgds 억제제로서 다중헤테로아릴 화합물 및 프로스타글란딘 d2 매개된 질병의 치료를 위한 그의 용도
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519637A (en) 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
DE2142585A1 (de) * 1971-08-20 1973-02-22 Schering Ag 2-(5-nitro-2-thiazolyl)-benzimidazole
FR2284601A1 (fr) * 1974-09-10 1976-04-09 Inst Francais Du Petrole Composes guanidino-heterocycliques alkyles, leur preparation et leur utilisation comme additifs pour carburants et lubrifiants
US4220654A (en) 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4374843A (en) 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles

Also Published As

Publication number Publication date
FI831595A0 (fi) 1983-05-09
ES8407045A1 (es) 1984-08-16
IE55229B1 (en) 1990-07-04
GT198302123A (es) 1984-10-27
US4435396A (en) 1984-03-06
PT76662B (en) 1986-04-16
FI78481C (fi) 1989-08-10
SU1195907A3 (ru) 1985-11-30
DK205883D0 (da) 1983-05-09
PL141199B1 (en) 1987-07-31
CS252461B2 (en) 1987-09-17
KR840004745A (ko) 1984-10-24
NZ204158A (en) 1986-05-09
EG17029A (en) 1992-06-30
DD209828A5 (de) 1984-05-23
AU3081584A (en) 1984-11-08
EP0094191B1 (en) 1988-04-20
YU99683A (en) 1986-02-28
KR860000931B1 (ko) 1986-07-19
IE831061L (en) 1983-11-10
EP0094191A1 (en) 1983-11-16
IL68630A (en) 1987-03-31
ATE33649T1 (de) 1988-05-15
HU190899B (en) 1986-12-28
GR79279B (es) 1984-10-22
CS318483A2 (en) 1987-02-12
ES522223A0 (es) 1984-08-16
DK205883A (da) 1983-11-11
FI831595L (fi) 1983-11-11
AU539244B2 (en) 1984-09-20
FI78481B (fi) 1989-04-28
AU566755B2 (en) 1987-10-29
PT76662A (en) 1983-06-01
AU1436383A (en) 1983-11-17
NO159932C (no) 1989-02-22
JPS58206588A (ja) 1983-12-01
ZA833286B (en) 1984-12-24
NO159932B (no) 1988-11-14
PL241840A1 (en) 1985-01-16
DE3376322D1 (en) 1988-05-26
IL68630A0 (en) 1983-09-30
HU196377B (en) 1988-11-28
NO831632L (no) 1983-11-11
DK163829B (da) 1992-04-06
CA1201120A (en) 1986-02-25

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