DK205883A - Fremgangsmaade til fremstilling af 2-guanidino-4-(2-(substitueret-amino)-4-imidazolyl)-thiazoler - Google Patents

Fremgangsmaade til fremstilling af 2-guanidino-4-(2-(substitueret-amino)-4-imidazolyl)-thiazoler Download PDF

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Publication number
DK205883A
DK205883A DK205883A DK205883A DK205883A DK 205883 A DK205883 A DK 205883A DK 205883 A DK205883 A DK 205883A DK 205883 A DK205883 A DK 205883A DK 205883 A DK205883 A DK 205883A
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Prior art keywords
thiazoles
guanidino
imidazolyl
amino
substituted
Prior art date
Application number
DK205883A
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English (en)
Other versions
DK163829B (da
DK205883D0 (da
Inventor
John Lawrence Lamattina
Christopher Andrew Lipinski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK205883D0 publication Critical patent/DK205883D0/da
Publication of DK205883A publication Critical patent/DK205883A/da
Publication of DK163829B publication Critical patent/DK163829B/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88Nitrogen atoms, e.g. allantoin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Lubricants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
DK205883A 1982-05-10 1983-05-09 Fremgangsmaade til fremstilling af 2-guanidino-4-(2-(substitueret-amino)-4-imidazolyl)-thiazoler DK163829B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/376,486 US4435396A (en) 1982-05-10 1982-05-10 Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
US37648682 1982-05-10

Publications (3)

Publication Number Publication Date
DK205883D0 DK205883D0 (da) 1983-05-09
DK205883A true DK205883A (da) 1983-11-11
DK163829B DK163829B (da) 1992-04-06

Family

ID=23485203

Family Applications (1)

Application Number Title Priority Date Filing Date
DK205883A DK163829B (da) 1982-05-10 1983-05-09 Fremgangsmaade til fremstilling af 2-guanidino-4-(2-(substitueret-amino)-4-imidazolyl)-thiazoler

Country Status (26)

Country Link
US (1) US4435396A (da)
EP (1) EP0094191B1 (da)
JP (1) JPS58206588A (da)
KR (1) KR860000931B1 (da)
AT (1) ATE33649T1 (da)
AU (2) AU539244B2 (da)
CA (1) CA1201120A (da)
CS (1) CS252461B2 (da)
DD (1) DD209828A5 (da)
DE (1) DE3376322D1 (da)
DK (1) DK163829B (da)
EG (1) EG17029A (da)
ES (1) ES522223A0 (da)
FI (1) FI78481C (da)
GR (1) GR79279B (da)
GT (1) GT198302123A (da)
HU (2) HU190899B (da)
IE (1) IE55229B1 (da)
IL (1) IL68630A (da)
NO (1) NO159932C (da)
NZ (1) NZ204158A (da)
PL (1) PL141199B1 (da)
PT (1) PT76662B (da)
SU (1) SU1195907A3 (da)
YU (1) YU42857B (da)
ZA (1) ZA833286B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554276A (en) * 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
US4673677A (en) * 1983-10-03 1987-06-16 Pfizer Inc. Method for treatment of gastrointestinal disorders
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4636498A (en) * 1984-10-11 1987-01-13 Pfizer Inc. Formulation of antiinflammatory drugs
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
WO1986003203A1 (en) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
DE3772301D1 (de) * 1986-08-29 1991-09-26 Pfizer 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren.
ATE106884T1 (de) * 1986-10-29 1994-06-15 Pfizer Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat.
CA2165344A1 (en) * 1993-06-15 1994-12-22 Peter C. Canning Immune stimulants in bacterial infections
WO2010033977A2 (en) * 2008-09-22 2010-03-25 Cayman Chemical Company Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519637A (en) 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
DE2142585A1 (de) * 1971-08-20 1973-02-22 Schering Ag 2-(5-nitro-2-thiazolyl)-benzimidazole
FR2284601A1 (fr) * 1974-09-10 1976-04-09 Inst Francais Du Petrole Composes guanidino-heterocycliques alkyles, leur preparation et leur utilisation comme additifs pour carburants et lubrifiants
US4220654A (en) 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4374843A (en) 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles

Also Published As

Publication number Publication date
FI831595A0 (fi) 1983-05-09
ES8407045A1 (es) 1984-08-16
CS318483A2 (en) 1987-02-12
IL68630A0 (en) 1983-09-30
FI78481C (fi) 1989-08-10
PL141199B1 (en) 1987-07-31
AU539244B2 (en) 1984-09-20
NO159932B (no) 1988-11-14
FI78481B (fi) 1989-04-28
IE55229B1 (en) 1990-07-04
DE3376322D1 (en) 1988-05-26
NO159932C (no) 1989-02-22
ATE33649T1 (de) 1988-05-15
DD209828A5 (de) 1984-05-23
PT76662B (en) 1986-04-16
YU42857B (en) 1988-12-31
AU1436383A (en) 1983-11-17
SU1195907A3 (ru) 1985-11-30
AU3081584A (en) 1984-11-08
FI831595L (fi) 1983-11-11
CA1201120A (en) 1986-02-25
CS252461B2 (en) 1987-09-17
GR79279B (da) 1984-10-22
ES522223A0 (es) 1984-08-16
DK163829B (da) 1992-04-06
IE831061L (en) 1983-11-10
AU566755B2 (en) 1987-10-29
NO831632L (no) 1983-11-11
EG17029A (en) 1992-06-30
NZ204158A (en) 1986-05-09
KR860000931B1 (ko) 1986-07-19
EP0094191B1 (en) 1988-04-20
JPS58206588A (ja) 1983-12-01
PL241840A1 (en) 1985-01-16
HU190899B (en) 1986-12-28
HU196377B (en) 1988-11-28
DK205883D0 (da) 1983-05-09
ZA833286B (en) 1984-12-24
EP0094191A1 (en) 1983-11-16
KR840004745A (ko) 1984-10-24
GT198302123A (es) 1984-10-27
US4435396A (en) 1984-03-06
YU99683A (en) 1986-02-28
PT76662A (en) 1983-06-01
IL68630A (en) 1987-03-31

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