YU402A - Novi derivati 2,3-benzodiazepina - Google Patents

Novi derivati 2,3-benzodiazepina

Info

Publication number
YU402A
YU402A YU402A YUP402A YU402A YU 402 A YU402 A YU 402A YU 402 A YU402 A YU 402A YU P402 A YUP402 A YU P402A YU 402 A YU402 A YU 402A
Authority
YU
Yugoslavia
Prior art keywords
bond
positions
hydrogen
lower alkyl
present
Prior art date
Application number
YU402A
Other languages
English (en)
Inventor
Zoltan Greff
Geza Szabo
Jozsef Barkoczy
Zoltan Ratkai
Gabor Blasko
Gyula Simlg
Gabor Gigler
Marko Bernadett Martonne
Gyorgy Levay
Karoly Tihanyi
Andras Egyed
Annamaria Simo
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of YU402A publication Critical patent/YU402A/sh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Predmetni pronalazak se odnosi na nove derivate 2,3-benzodiazepina, opste formule (I), (naznacene time sto R1 oznacava metil, formil, karboksi, cijano, -CH=NOH, -CH=NNHCONH2 ili -NR5R6 grupu, naznacenu time sto R5 i R6 nezavisno jedno od drugog, predstavljaju vodonik ili nizi alkil ili zajedno sa atomom azota za koji su vezani obrazuju petoclani iil sestoclani zasiceni ili nezasiceni heterociklicni prsten, koji opciono sadrzi jedan ili vise dodatnih atoma azota, sumpora i/ili kiseonika, R2 je nitro ili amino grupa, R3 oznacava vodonik, nizi alkanoil ili grupu CO-NR7R8, naznacenu time sto R7 i R8 nezavisno jedno od drugog, predstavljaju vodonik, nizi alkoksi, nizi alkil ili nizi cikloalkil ili zajedno sa atomom azota za koji su vezani obrazuju petoclani ili sestoclani zasiceni ili nezasiceni heterociklicni prsten, koji opciono sadrzi jedan ili vise dodatnih atoma azota, sumpora i/li kiseonika, R4 je vodonik ili nizi alkil, a isprekidane linije imaju sledece znacenje: ako R3 i R4 nisu prisutni, veza izmedju pozicija C8 i C9 je jednoguba, a veza izmedju pozicija C8 i N7 je dvoguba, ako su R3 i R4 prisutni, veze izmedju pozicija C8 i C9 i pozicija C8 i N7 su jednogube veze, i ako je R3 prisutno, a R4 nedostaje, veza izmedju pozicija C8 i C9 je dvoguba, a veza izmedju pozicija C8 i N7 je jednoguba) i njihove soli. Jedinjenja predmetnog pronalaska imaju neuroprotekciono dejstvo.
YU402A 1999-07-07 2000-07-04 Novi derivati 2,3-benzodiazepina YU402A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9902291A HU227128B1 (en) 1999-07-07 1999-07-07 New 2,3-benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
YU402A true YU402A (sh) 2004-11-25

Family

ID=89998666

Family Applications (1)

Application Number Title Priority Date Filing Date
YU402A YU402A (sh) 1999-07-07 2000-07-04 Novi derivati 2,3-benzodiazepina

Country Status (22)

Country Link
US (1) US7053082B1 (sh)
EP (1) EP1200442B8 (sh)
JP (1) JP2003504372A (sh)
KR (1) KR100818001B1 (sh)
CN (1) CN1162432C (sh)
AT (1) ATE243699T1 (sh)
AU (1) AU5836300A (sh)
BG (1) BG65405B1 (sh)
CA (1) CA2378305A1 (sh)
CZ (1) CZ20014698A3 (sh)
DE (1) DE60003561T2 (sh)
DK (1) DK1200442T3 (sh)
HK (1) HK1047581B (sh)
HR (1) HRP20020015B1 (sh)
HU (1) HU227128B1 (sh)
PL (1) PL351839A1 (sh)
RO (1) RO121853B1 (sh)
RU (1) RU2243228C2 (sh)
SK (1) SK286680B6 (sh)
UA (1) UA72261C2 (sh)
WO (1) WO2001004122A2 (sh)
YU (1) YU402A (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225100B1 (hu) 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6858605B2 (en) 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
EA016087B1 (ru) * 2005-12-30 2012-02-28 Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез
FR2972454B1 (fr) * 2011-03-08 2013-03-01 Servier Lab Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU219777B (hu) * 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE4428835A1 (de) * 1994-08-01 1996-02-08 Schering Ag Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
DK1157992T3 (da) * 1994-08-31 2005-10-24 Lilly Co Eli Dihydro-2,3-benzodiazepinederivativer
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування

Also Published As

Publication number Publication date
DE60003561T2 (de) 2004-04-29
DK1200442T3 (da) 2003-10-20
BG106281A (en) 2003-01-31
KR20020022765A (ko) 2002-03-27
CZ20014698A3 (cs) 2002-06-12
HK1047581A1 (en) 2003-02-28
EP1200442B1 (en) 2003-06-25
ATE243699T1 (de) 2003-07-15
CA2378305A1 (en) 2001-01-18
AU5836300A (en) 2001-01-30
JP2003504372A (ja) 2003-02-04
WO2001004122A3 (en) 2001-05-10
BG65405B1 (bg) 2008-06-30
SK172002A3 (en) 2002-06-04
HU227128B1 (en) 2010-07-28
CN1370174A (zh) 2002-09-18
PL351839A1 (en) 2003-06-16
HRP20020015A2 (en) 2004-08-31
CN1162432C (zh) 2004-08-18
KR100818001B1 (ko) 2008-03-31
UA72261C2 (uk) 2005-02-15
RO121853B1 (ro) 2008-06-30
EP1200442A1 (en) 2002-05-02
EP1200442B8 (en) 2003-08-20
RU2243228C2 (ru) 2004-12-27
HU9902291D0 (en) 1999-09-28
HUP9902291A2 (hu) 2001-12-28
HRP20020015B1 (en) 2005-02-28
DE60003561D1 (de) 2003-07-31
US7053082B1 (en) 2006-05-30
WO2001004122A2 (en) 2001-01-18
HK1047581B (zh) 2004-04-30
SK286680B6 (sk) 2009-03-05

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