YU236390A - Derivati 10,11,12,13-tetrahidro-desmikozina i postupak za njihovo dobijanje - Google Patents

Derivati 10,11,12,13-tetrahidro-desmikozina i postupak za njihovo dobijanje

Info

Publication number
YU236390A
YU236390A YU236390A YU236390A YU236390A YU 236390 A YU236390 A YU 236390A YU 236390 A YU236390 A YU 236390A YU 236390 A YU236390 A YU 236390A YU 236390 A YU236390 A YU 236390A
Authority
YU
Yugoslavia
Prior art keywords
tetrahydro
stands
obtaining
desmycosin
derivatives
Prior art date
Application number
YU236390A
Other languages
English (en)
Inventor
Naranđa Amalija
Slobodan Đokić
Original Assignee
Pliva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva filed Critical Pliva
Priority to YU236390A priority Critical patent/YU236390A/sh
Priority to SI9012363A priority patent/SI9012363A/sl
Priority to CA002056823A priority patent/CA2056823C/en
Priority to ES91121070T priority patent/ES2089100T3/es
Priority to AT91121070T priority patent/ATE135708T1/de
Priority to EP91121070A priority patent/EP0490311B1/en
Priority to DK91121070.6T priority patent/DK0490311T3/da
Priority to DE69118126T priority patent/DE69118126T2/de
Priority to RO148931A priority patent/RO111684B1/ro
Priority to JP3327491A priority patent/JP2843695B2/ja
Priority to BG95629A priority patent/BG60571B1/bg
Priority to HU913937A priority patent/HU215156B/hu
Priority to PL91292767A priority patent/PL167042B1/pl
Priority to SU915010467A priority patent/RU2053238C1/ru
Priority to HU9802416A priority patent/HU219347B/hu
Priority to UA5010467A priority patent/UA34418C2/uk
Priority to SK3791-91A priority patent/SK278717B6/sk
Priority to CS913791A priority patent/CZ280809B6/cs
Priority to CN91107980A priority patent/CN1030659C/zh
Priority to HRP-2363/90A priority patent/HRP930855B1/xx
Publication of YU236390A publication Critical patent/YU236390A/sh
Priority to HU95P/P00743P priority patent/HU211493A9/hu
Priority to GR960401308T priority patent/GR3019942T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Izum se odnosi na derivate 10,11,12,13-tetrahidro-desmikozina, nove polusintetske antibiotike iz reda tilozina s antibakterijskim djelovanjem, njihove farmaceutski prihvatljive soli s organskim i anorganskim kiselinama i postupke za pripravu istih. Prema ovom izumu u prvom stupnju provede se acetalizacija položaja C-20. Dobiveni 10,11,12,13-tetrahidro-desmikozin dietilacetal reakcijom sa trimetilklorsilanom provede se u 3,2 4-tri-0-trimetilsulil-10,11,12,13-tetrahidro-desmikozin dietilacetal, koji se zatim reakcijom sa metansulfokloridom prevede u 4 -metansulfonil-3,2,4-tri-0-trimetilsilil-10,11,12,13-tetrahidro-desmikozin dietilacetal. Isti se reakcijom sa natrijevim jodidom prevede u 4 -deoksi-4 -jod-3,2,4 -tri-0-trimetilsilil-10,11,12,13-tetrahidro-desmikozin dietilacetal, koji se podvrgne hidrolizi zaštitnih skupina u smjesi acetonitrila i 0.2 N HCL. Dobije se sirovi 4 -deoksi-4 -jod-10,11,12,13-tetrahidro- desmikozin, koji se čisti na stupcu silikagela. Provede se dejodiranje uz katalitičku količinu paladija na ugljenu i izolira čisti 4 -deoksi-10,11,12,13-tetrahdro-desmikozin.
YU236390A 1990-12-14 1990-12-14 Derivati 10,11,12,13-tetrahidro-desmikozina i postupak za njihovo dobijanje YU236390A (sh)

Priority Applications (22)

Application Number Priority Date Filing Date Title
YU236390A YU236390A (sh) 1990-12-14 1990-12-14 Derivati 10,11,12,13-tetrahidro-desmikozina i postupak za njihovo dobijanje
SI9012363A SI9012363A (sl) 1990-12-14 1990-12-14 Derivati 10,11,12,13-tetrahidro-desmikozina, postopki za njihovo pripravo in postopki za pripravo farmacevtskih preparatov
CA002056823A CA2056823C (en) 1990-12-14 1991-12-05 Derivatives of 10,11,12,13-tetrahydrodesmycosin processes for preparation, and use thereof in pharmaceuticals
ES91121070T ES2089100T3 (es) 1990-12-14 1991-12-09 Derivados de 10,11,12,13-tetra-hidrodesmicosina, procedimiento para su preparacion, y su utilizacion en la produccion de productos farmaceuticos.
AT91121070T ATE135708T1 (de) 1990-12-14 1991-12-09 Derivate von 10,11,12,13-tetra-hydrodesmycosin, verfahren zu ihrer herstellung, und ihre verwendung zur herstellung von arzneimitteln
EP91121070A EP0490311B1 (en) 1990-12-14 1991-12-09 Derivatives of 10,11,12,13-tetra-hydrodesmycosin, processes for preparation, and use thereof in obtaining pharmaceuticals
DK91121070.6T DK0490311T3 (da) 1990-12-14 1991-12-09 Derivater af 10,11,12,13-tetrahydro-desmycosin, fremgangsmåder til fremstilling deraf og anvendelse deraf til opnåelse af farmaceutiske præparater
DE69118126T DE69118126T2 (de) 1990-12-14 1991-12-09 Derivate von 10,11,12,13-tetra-hydrodesmycosin, Verfahren zu ihrer Herstellung, und ihre Verwendung zur Herstellung von Arzneimitteln
RO148931A RO111684B1 (ro) 1990-12-14 1991-12-10 Derivati de 10,11,12,13-tetrahidrodesmicosina si procedeu pentru prepararea acestora
JP3327491A JP2843695B2 (ja) 1990-12-14 1991-12-11 １０，１１，１２，１３−テトラヒドロ−デスマイコシン誘導体、その製造法及びその医薬としての用途
HU913937A HU215156B (hu) 1990-12-14 1991-12-13 Eljárás 4'-dezoxi-10,11,12,13-tetrahidro-demikozin és ezt a vegyületet tartalmazó gyógyászati készítmények előállítására
BG95629A BG60571B1 (bg) 1990-12-14 1991-12-13 Производни на 10,11,12,13-тетрахидродезмикозин, метод за получаването им и употребата им като фармацевтични препарати
PL91292767A PL167042B1 (pl) 1990-12-14 1991-12-13 Sposób wytwarzania nowej 4’-dezoksy-10,11,12,13-tetrahydrodezmykozyny PL PL PL PL PL PL PL
SU915010467A RU2053238C1 (ru) 1990-12-14 1991-12-13 Производные 10,11,12,13-тетрагидродесмикозина или их фармацевтически приемлемые соли с органическими или неорганическими кислотами, обладающие антибактериальной активностью, способ получения производных 10,11,12,13-тетрагидродесмикозина или их фармацевтически приемлемых солей
HU9802416A HU219347B (en) 1990-12-14 1991-12-13 10,11,12,13-tetrahydro-desmycosin derivatives and pharmaceutical compositions containing 4'-deoxy-10,11,12,13-tetrahydro-desmycosin
UA5010467A UA34418C2 (uk) 1990-12-14 1991-12-13 Похідне 10,11,12,13-тетрагідродесмікозину, проміжні сполуки та спосіб одержання похідного 10,11,12,13-тетрагідродесмікозину
SK3791-91A SK278717B6 (sk) 1990-12-14 1991-12-13 Deriváty 10, 11, 12, 13-tetrahydrodesmykozínu, spô
CS913791A CZ280809B6 (cs) 1990-12-14 1991-12-13 Deriváty 10,11,12,13-tetrahydrodesmykosinu, způsoby jejich přípravy a jejich použití v léčivech
CN91107980A CN1030659C (zh) 1990-12-14 1991-12-14 10，11，12，13-四氢-脱碳霉糖泰乐菌素衍生物的制备方法
HRP-2363/90A HRP930855B1 (en) 1990-12-14 1993-05-05 10, 11,12,13-tetrahydro-desmicosine and a process for the preparation thereof
HU95P/P00743P HU211493A9 (en) 1990-12-14 1995-07-03 Derivatives 10, 11, 12, 13-tetrahydrodesmycosin, processes for preparation and use thereof in pharmaceuticals
GR960401308T GR3019942T3 (en) 1990-12-14 1996-05-16 Derivatives of 10,11,12,13-tetra-hydrodesmycosin, processes for preparation, and use thereof in obtaining pharmaceuticals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU236390A YU236390A (sh) 1990-12-14 1990-12-14 Derivati 10,11,12,13-tetrahidro-desmikozina i postupak za njihovo dobijanje

Publications (1)

Publication Number Publication Date
YU236390A true YU236390A (sh) 1993-05-28

Family

ID=25557732

Family Applications (1)

Application Number Title Priority Date Filing Date
YU236390A YU236390A (sh) 1990-12-14 1990-12-14 Derivati 10,11,12,13-tetrahidro-desmikozina i postupak za njihovo dobijanje

Country Status (19)

Country Link
EP (1) EP0490311B1 (sh)
JP (1) JP2843695B2 (sh)
CN (1) CN1030659C (sh)
AT (1) ATE135708T1 (sh)
BG (1) BG60571B1 (sh)
CA (1) CA2056823C (sh)
CZ (1) CZ280809B6 (sh)
DE (1) DE69118126T2 (sh)
DK (1) DK0490311T3 (sh)
ES (1) ES2089100T3 (sh)
GR (1) GR3019942T3 (sh)
HU (2) HU215156B (sh)
PL (1) PL167042B1 (sh)
RO (1) RO111684B1 (sh)
RU (1) RU2053238C1 (sh)
SI (1) SI9012363A (sh)
SK (1) SK278717B6 (sh)
UA (1) UA34418C2 (sh)
YU (1) YU236390A (sh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3266893A (en) * 1992-01-14 1993-08-03 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 3,4'-dideoxymycaminosyltylonolide derivative and production thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056616A (en) * 1976-03-05 1977-11-01 Schering Corporation Rosamicin derivatives and method of using same
AU551142B2 (en) * 1981-07-09 1986-04-17 Zaidan Hojin Biseibutsu Kagaku Kenkyukai Tylosin derivatives
YU45033B (en) * 1987-04-14 1991-06-30 Pliva Zagreb Process for preparing 10,11,12,13-tetrahydro derivative
US5026832A (en) * 1988-12-26 1991-06-25 Toyo Jozo Co., Ltd. 9-dihydro-9-O-alkyldesmycosin derivatives
SI8911498B (sl) * 1989-07-26 1998-10-31 Pliva Postopek za pripravo derivatov tilozina

Also Published As

Publication number Publication date
GR3019942T3 (en) 1996-08-31
HU215156B (hu) 1998-12-28
CZ280809B6 (cs) 1996-04-17
CS379191A3 (en) 1992-06-17
HUT59936A (en) 1992-07-28
ATE135708T1 (de) 1996-04-15
DE69118126D1 (de) 1996-04-25
SK278717B6 (sk) 1998-01-14
CN1062535A (zh) 1992-07-08
HU211493A9 (en) 1995-11-28
CA2056823C (en) 1999-04-27
JP2843695B2 (ja) 1999-01-06
RO111684B1 (ro) 1996-12-30
PL292767A1 (en) 1992-11-16
ES2089100T3 (es) 1996-10-01
RU2053238C1 (ru) 1996-01-27
BG60571B1 (bg) 1995-09-29
UA34418C2 (uk) 2001-03-15
BG95629A (en) 1994-03-31
DK0490311T3 (da) 1996-07-22
EP0490311B1 (en) 1996-03-20
SI9012363A (sl) 1998-04-30
CN1030659C (zh) 1996-01-10
DE69118126T2 (de) 1996-10-31
HU913937D0 (en) 1992-02-28
JPH05194577A (ja) 1993-08-03
EP0490311A1 (en) 1992-06-17
CA2056823A1 (en) 1992-06-15
PL167042B1 (pl) 1995-07-31

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