YU120290A - Novi derivati r(-)3-kinuklidinola - Google Patents

Novi derivati r(-)3-kinuklidinola

Info

Publication number
YU120290A
YU120290A YU120290A YU120290A YU120290A YU 120290 A YU120290 A YU 120290A YU 120290 A YU120290 A YU 120290A YU 120290 A YU120290 A YU 120290A YU 120290 A YU120290 A YU 120290A
Authority
YU
Yugoslavia
Prior art keywords
absent
straight
lower alkyl
derivatives
alkyl group
Prior art date
Application number
YU120290A
Other languages
English (en)
Other versions
YU47356B (sh
Inventor
E. Cereda
A. Donetti
G. Bietti
A. Schiavone
G.B. Schiavi
H.N. Doods
Original Assignee
Istituto De Angeli S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto De Angeli S.P.A. filed Critical Istituto De Angeli S.P.A.
Publication of YU120290A publication Critical patent/YU120290A/sh
Publication of YU47356B publication Critical patent/YU47356B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

NOVI DERIVATI R(-)3-KINUKLIDINOLA,opisani so farmakološko aktivni derivati R (-) 3-kinuklidinola, ki so blokirna sredstva muskarinskih receptorjev, ki so uporabna za zdravljenje motenj gastrointestinalnega in respiratornega trakta, s sledečo formulo (I) kjer R pomeni ravno ali razvejeno nižjo alkilno skupino, cikloalkil-C1-2-alkilno ali aralkilno skupino, ali pa je odsoten; X pomeni anion organske ali anorganske kisline, ali pa je odsoten, če je R odsoten; R1 pomeni H, ravno ali razvejeno nižjo alkilno skupino ali acilno skupino vrste R2-CO, v kateri je R2 H ali ravna ali razvejena nižja alkilna skupina; A pomeni cikloalkil, aromatski obroč ali 5-ali 6-členski heterocikličen obroč; X in Z sta lahko istočasno ali izmenično prisotna ali odsotna; če sta istočasno prisotna, pomenita kisik; če je prisoten samo eden od njiju, je kisik ali žveplo; n je 1,2 ali 3-kinuklidinil estra sta vezana istočasno na isti ogljikov atom obroča, kar privede do geminalne substitucije. Opisani so tudi postopek za pripravo spojin s formulo (I) kot tudi farmacevtski pripravki, ki jih vsebujejo.
YU120290A 1989-06-20 1990-06-19 Novi derivati r(-)3-kinuklidinola i postupak za njihovo dobijanje YU47356B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8920929A IT1230881B (it) 1989-06-20 1989-06-20 Derivati del r(-) 3-chinuclidinolo

Publications (2)

Publication Number Publication Date
YU120290A true YU120290A (sh) 1992-12-21
YU47356B YU47356B (sh) 1995-01-31

Family

ID=11174223

Family Applications (1)

Application Number Title Priority Date Filing Date
YU120290A YU47356B (sh) 1989-06-20 1990-06-19 Novi derivati r(-)3-kinuklidinola i postupak za njihovo dobijanje

Country Status (19)

Country Link
US (1) US5164386A (sh)
EP (1) EP0404737A3 (sh)
JP (1) JPH0331279A (sh)
KR (1) KR910000720A (sh)
AU (1) AU634787B2 (sh)
CA (1) CA2019251A1 (sh)
DD (1) DD300105A5 (sh)
FI (1) FI94131C (sh)
HU (1) HUT54151A (sh)
IE (1) IE902208A1 (sh)
IL (1) IL94763A (sh)
IT (1) IT1230881B (sh)
NO (1) NO174053C (sh)
NZ (1) NZ234157A (sh)
PL (1) PL164218B1 (sh)
PT (1) PT94408A (sh)
RU (1) RU2034843C1 (sh)
YU (1) YU47356B (sh)
ZA (1) ZA904736B (sh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9106571D0 (en) * 1991-03-27 1991-05-15 Erba Carlo Spa Derivatives of substituted imidazol-2-one and process for their preparation
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes
AU7618991A (en) * 1990-05-14 1991-11-14 Syntex (U.S.A.) Inc. Novel tricyclic compounds
WO1992012151A1 (en) * 1991-01-10 1992-07-23 Pfizer Inc. N-alkyl quinuclidinium salts as substance p antagonists
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
JP4295985B2 (ja) 2000-12-28 2009-07-15 ラボラトリオス・アルミラル・ソシエダッド・アノニマ 新規なキヌクリジン誘導体およびそれを含む医薬組成物
CA3178035A1 (en) 2012-12-24 2014-07-03 Neurogastrx, Inc. Methods for treating gi tract disorders
WO2015200369A1 (en) 2014-06-24 2015-12-30 Neurogastrx, Inc. Prodrugs of metopimazine
KR102423577B1 (ko) 2017-04-07 2022-07-21 삼성전자주식회사 가전기기
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3290316A (en) * 1962-08-03 1966-12-06 Hoffmann La Roche Alpha-3-pyridylmandelic acid and derivatives thereof
WO1985001048A1 (en) * 1983-08-26 1985-03-14 Sandoz Ag Aromatic esters or amides of carboxylic acid and sulfonic acid
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
ZA886585B (en) * 1987-09-08 1990-05-30 Lilly Co Eli Specific 5-ht,antagonists
US4921982A (en) * 1988-07-21 1990-05-01 Eli Lilly And Company 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists
IT1231413B (it) * 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
US4975437A (en) * 1989-12-14 1990-12-04 Marion Laboratories, Inc. Isomers of 1-azabicyclo(2.2.2)oct-3-yl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-nitropyridine-3-carboxylate

Also Published As

Publication number Publication date
HU903908D0 (en) 1990-11-28
PT94408A (pt) 1991-02-08
YU47356B (sh) 1995-01-31
EP0404737A3 (en) 1992-03-11
US5164386A (en) 1992-11-17
IT8920929A0 (it) 1989-06-20
FI903077A0 (fi) 1990-06-19
AU634787B2 (en) 1993-03-04
JPH0331279A (ja) 1991-02-12
NO174053B (no) 1993-11-29
AU5764990A (en) 1991-01-03
IL94763A0 (en) 1991-04-15
IT1230881B (it) 1991-11-08
HUT54151A (en) 1991-01-28
NO902710D0 (no) 1990-06-19
IL94763A (en) 1994-08-26
DD300105A5 (de) 1992-05-21
CA2019251A1 (en) 1990-12-20
NO902710L (no) 1990-12-21
FI94131C (fi) 1995-07-25
ZA904736B (en) 1992-02-26
EP0404737A2 (en) 1990-12-27
PL285669A1 (en) 1991-03-11
NO174053C (no) 1994-03-16
FI94131B (fi) 1995-04-13
RU2034843C1 (ru) 1995-05-10
IE902208L (en) 1990-12-20
KR910000720A (ko) 1991-01-30
NZ234157A (en) 1992-09-25
IE902208A1 (en) 1991-01-02
PL164218B1 (pl) 1994-07-29

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