ATE138663T1 - Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel - Google Patents

Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel

Info

Publication number
ATE138663T1
ATE138663T1 AT88310040T AT88310040T ATE138663T1 AT E138663 T1 ATE138663 T1 AT E138663T1 AT 88310040 T AT88310040 T AT 88310040T AT 88310040 T AT88310040 T AT 88310040T AT E138663 T1 ATE138663 T1 AT E138663T1
Authority
AT
Austria
Prior art keywords
hydrogen
group
sec
oxothiolans
derivatives
Prior art date
Application number
AT88310040T
Other languages
English (en)
Inventor
Abraham Fisher
Ishai Karton
Original Assignee
Israel State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Israel State filed Critical Israel State
Application granted granted Critical
Publication of ATE138663T1 publication Critical patent/ATE138663T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
AT88310040T 1987-10-28 1988-10-26 Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel ATE138663T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11447387A 1987-10-28 1987-10-28
US07/189,210 US4876260A (en) 1987-10-28 1988-05-02 Oxathiolanes

Publications (1)

Publication Number Publication Date
ATE138663T1 true ATE138663T1 (de) 1996-06-15

Family

ID=26812231

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88310040T ATE138663T1 (de) 1987-10-28 1988-10-26 Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel

Country Status (13)

Country Link
US (1) US4876260A (de)
EP (1) EP0314444B1 (de)
JP (1) JP2753280B2 (de)
KR (1) KR910007979B1 (de)
AT (1) ATE138663T1 (de)
AU (1) AU608903B2 (de)
CA (1) CA1315791C (de)
DE (1) DE3855325T2 (de)
DK (1) DK175064B1 (de)
ES (1) ES2087854T3 (de)
IL (1) IL87834A (de)
NO (1) NO167806C (de)
NZ (1) NZ226415A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
JP2683783B2 (ja) * 1992-07-10 1997-12-03 雪印乳業株式会社 シェーグレン症候群治療剤
DE4343838C2 (de) * 1993-12-22 1998-07-09 Lohmann Therapie Syst Lts Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung
US6572880B2 (en) 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US6290986B1 (en) 1996-10-24 2001-09-18 Pharmaceutical Applications Associates, Llc Method and composition for transdermal administration of pharmacologic agents
US6479074B2 (en) 1996-10-24 2002-11-12 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
NZ500643A (en) 1997-05-30 2001-12-21 Neurosearch As Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators
US20040209849A1 (en) * 1998-11-27 2004-10-21 Sanochemia Pharmazeutika Aktiengesellschaft Use of effectors of the central cholinergic nervous system for treatment of delirium
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
US6433168B1 (en) 1999-07-26 2002-08-13 Sumika Fine Chemicals Co., Ltd. Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
EP2320661B8 (de) 2001-11-29 2015-09-02 Godo Kaisha IP Bridge 1 Entfernungsverfahren für die Codierungsverzerrung
MXPA04010921A (es) * 2002-05-03 2005-05-27 Israel Inst Biolog Res Metodos y composiciones para el tratamietno de trastornos del sistema nervioso central y periferico y compuestos novedosos utiles para los mismos.
JP2009541342A (ja) * 2006-06-20 2009-11-26 ワイス Ｋｖ１．５カリウムチャネル阻害剤
US8143400B2 (en) * 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
PE20110777A1 (es) * 2008-11-23 2011-10-29 Pfizer Nuevas lactamas como inhibidores de beta secretasa
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
BRPI1007350B8 (pt) 2009-01-26 2021-05-25 Israel Institute For Biological Res compostos espiro heterocíclicos bicíclicos
CN101798311A (zh) * 2010-04-07 2010-08-11 天津炜杰凯华科技有限公司 顺式西维美林的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2146962A1 (en) * 1971-07-28 1973-03-09 Yoshitomi Pharmaceutical Aza-spirodecanones - useful in treating gastric disorders
IL48453A (en) * 1975-11-11 1980-06-30 Purdue Frederick Co Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
IL48452A (en) * 1975-11-11 1979-07-25 Purdue Frederick Co Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
US4855290A (en) * 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
ZA868369B (en) * 1986-01-10 1987-11-25 Israel State Derivatives of quinuclidine
IL87234A (en) * 1987-08-13 1992-02-16 Israel Inst Biolog Res Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR890006641A (ko) 1989-06-15
NO167806B (no) 1991-09-02
NZ226415A (en) 1990-05-28
NO884790L (no) 1989-05-02
EP0314444A2 (de) 1989-05-03
EP0314444A3 (en) 1990-11-07
US4876260A (en) 1989-10-24
ES2087854T3 (es) 1996-08-01
DE3855325D1 (de) 1996-07-04
JP2753280B2 (ja) 1998-05-18
DE3855325T2 (de) 1996-10-10
AU2367188A (en) 1989-05-04
CA1315791C (en) 1993-04-06
NO167806C (no) 1991-12-11
NO884790D0 (no) 1988-10-27
EP0314444B1 (de) 1996-05-29
KR910007979B1 (ko) 1991-10-05
DK598688A (da) 1989-04-29
DK598688D0 (da) 1988-10-27
DK175064B1 (da) 2004-05-17
IL87834A0 (en) 1989-03-31
JPH0262883A (ja) 1990-03-02
IL87834A (en) 1992-05-25
AU608903B2 (en) 1991-04-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time