GB1510370A - Pharmaceutical preparations for the treatment of coronary heart diseases - Google Patents

Pharmaceutical preparations for the treatment of coronary heart diseases

Info

Publication number
GB1510370A
GB1510370A GB53300/75A GB5330075A GB1510370A GB 1510370 A GB1510370 A GB 1510370A GB 53300/75 A GB53300/75 A GB 53300/75A GB 5330075 A GB5330075 A GB 5330075A GB 1510370 A GB1510370 A GB 1510370A
Authority
GB
United Kingdom
Prior art keywords
radical
compound
ring
salt
coronary heart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB53300/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1510370A publication Critical patent/GB1510370A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1510370 Compositions for treating coronary heart disease CIBA - GEIGY AG 31 Dec 1975 [6 Jan 1975] 53300/75 Heading A5B Pharmaceutical preparations for the treatment of coronary heart disease contain (1) a beta - receptor blocking compound of the formula:- wherein Ar 1 represents a monocyclic or polycyclic, carbocyclic or heterocyclic radical which contains at least one ring of aromatic character, and which is 'bonded to the oxygen atom via a ring carbon atom, preferably of the ring of aromatic character R 1 denotes an optionally substituted aliphatic, cycloaliphatic or araliphatic hydrocarbon radical and R 2 represents hydrogen or the acyl radical of an organic carboxylic acid, or a compound of the formula wherein R 1 and R 2 have the abovementioned meanings, Ar 2 represents a monocyclic or polycyclic, carbocyclic radical which contains at least one ring of aromatic character, and R 3 denotes hydrogen or lower alkyl, or a salt of such compounds which can be used pharmaceutically, (2) a compound which regulates the thrombocyte function which is acetylsalicylic acid or a salt thereof with a base which can be used pharmaceutically, 2, 6 - bis- [di - (2 - hydroxyethyl) - amino] - 4, 8 - di - piperidino - pyrimido [5, 4 - d] pyrimidine, or an acid addition salt thereof which can be used pharmacetically or a compound of the formula wherein each of the radicals Ph 1 and Ph 2 independently of one another represents a phenyl radical which is optionally substituted by lower alkyl, hydroxyl, lower alkoxy and/or halogen, Alk denotes a lower alkylene radical which separates the sulphur atom from the ring carbon atom by at least 2 carbon atoms, n represents 0, 1 or 2 and Ph 3 represents a phenyl radical which is optionally substituted by lower alkyl, lower alkoxy and/or halogen, or a salt thereof with a base, which can be used pharmacologically, and optionally (3), an alpha - receptor blocking compound which is a hydrogenated ergot alkaloid, or a mixture of such alkaloids or acid addition salts thereof which can be used pharmaceutically, or a N - benzyl - N - halogeno - lower alkylamine, a 2 - tert. - aminomethyl - benzodioxane, a N - substituted dibenzazepine or a methyl - 2 - imidazoline which is substituted in the 2 - position or acid addition salts of such compounds which can be used pharmaceutically.
GB53300/75A 1975-01-06 1975-12-31 Pharmaceutical preparations for the treatment of coronary heart diseases Expired GB1510370A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH7175 1975-01-06

Publications (1)

Publication Number Publication Date
GB1510370A true GB1510370A (en) 1978-05-10

Family

ID=4178628

Family Applications (1)

Application Number Title Priority Date Filing Date
GB53300/75A Expired GB1510370A (en) 1975-01-06 1975-12-31 Pharmaceutical preparations for the treatment of coronary heart diseases

Country Status (14)

Country Link
JP (1) JPS5191337A (en)
AU (1) AU499140B2 (en)
BE (1) BE837293A (en)
CA (1) CA1063516A (en)
DE (1) DE2600069A1 (en)
FR (1) FR2296430A1 (en)
GB (1) GB1510370A (en)
HK (1) HK49680A (en)
IE (1) IE42766B1 (en)
IL (1) IL48785A (en)
MY (1) MY8100159A (en)
NL (1) NL7600045A (en)
NZ (1) NZ179623A (en)
ZA (2) ZA7628B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051262A (en) * 1979-12-07 1991-09-24 Elan Corp., P.L.C. Processes for the preparation of delayed action and programmed release pharmaceutical forms and medicaments obtained thereby

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0019006A1 (en) * 1979-05-14 1980-11-26 Ciba-Geigy Ag Pharmaceutical preparations containing a substituted pyrazolidine derivative as active substance, their application and manufacturing process
TW284688B (en) * 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
US5731339A (en) * 1995-04-28 1998-03-24 Zonagen, Inc. Methods and formulations for modulating the human sexual response

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL37700A (en) * 1970-10-02 1975-05-22 Ciba Geigy Ag Pharmaceutical preparations containing an aryloxypropanolamine derivative or an arylethanolamine derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051262A (en) * 1979-12-07 1991-09-24 Elan Corp., P.L.C. Processes for the preparation of delayed action and programmed release pharmaceutical forms and medicaments obtained thereby

Also Published As

Publication number Publication date
ZA7626B (en) 1976-12-29
IL48785A0 (en) 1976-03-31
DE2600069A1 (en) 1976-07-15
AU499140B2 (en) 1979-04-05
MY8100159A (en) 1981-12-31
IE42766B1 (en) 1980-10-08
IE42766L (en) 1976-07-06
JPS5191337A (en) 1976-08-10
BE837293A (en) 1976-07-05
FR2296430B1 (en) 1978-11-10
ZA7628B (en) 1976-12-29
NZ179623A (en) 1978-03-06
IL48785A (en) 1978-08-31
HK49680A (en) 1980-09-12
AU1000276A (en) 1977-07-14
NL7600045A (en) 1976-07-08
FR2296430A1 (en) 1976-07-30
CA1063516A (en) 1979-10-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee