WO2024012386A1 - Composition contenant un extrait d'artemisia annua l. et un composant soluble dans l'huile, et son utilisation - Google Patents

Composition contenant un extrait d'artemisia annua l. et un composant soluble dans l'huile, et son utilisation Download PDF

Info

Publication number
WO2024012386A1
WO2024012386A1 PCT/CN2023/106478 CN2023106478W WO2024012386A1 WO 2024012386 A1 WO2024012386 A1 WO 2024012386A1 CN 2023106478 W CN2023106478 W CN 2023106478W WO 2024012386 A1 WO2024012386 A1 WO 2024012386A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
oil
artemisia annua
skin
preparation
Prior art date
Application number
PCT/CN2023/106478
Other languages
English (en)
Chinese (zh)
Inventor
孙懿
陈默
赵亚
贾海东
Original Assignee
上海家化联合股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 上海家化联合股份有限公司 filed Critical 上海家化联合股份有限公司
Publication of WO2024012386A1 publication Critical patent/WO2024012386A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82—Preparation or application process involves sonication or ultrasonication

Definitions

  • the present invention belongs to the field of phytochemistry, and specifically relates to a composition containing Artemisia annua extract and oil-soluble components and its application in external skin agents or cosmetics.
  • Allergic reactions can be divided into types I, II, III, and IV according to their mechanisms, and hyaluronidase is a participant in type I allergic reactions and has a strong correlation with inflammation and allergy.
  • Hyaluronidase is a specific cleavage enzyme of hyaluronic acid, and hyaluronic acid displays a variety of physiological functions of traditional Chinese medicine in the body, such as moisturizing and promoting wound healing. According to research reports, some anti-allergic and anti-inflammatory drugs strongly inhibit hyaluronidase activity. Therefore, inhibition of hyaluronidase activity is used as an indicator to study anti-inflammatory effects.
  • Artemisia annua is the whole plant of Artemisia annua L. in the Asteraceae family. Bitter and cold in nature. Returns to the liver, gallbladder, and kidney meridians. It has the effect of clearing away heat, relieving heat and cutting off malaria.
  • Artemisia annua contains the anti-malarial component artemisinin, which can directly kill malaria parasites.
  • Artemisia annua extract has antibacterial and insecticidal, antipyretic and anti-inflammatory, and immune-regulating effects. It also has five kinds of flavonoids with antioxidant activity. Ingredients, including quercetin, etc.
  • Schizonepeta is the above-ground part of Schizonepeta tenuifolia Briq. in the family Lamiaceae. Purgit and slightly warm in nature. Returns to the lung and liver meridians. It has the effect of dispersing wind, resolving rash and sores. Its water decoction can enhance skin blood circulation and has a weak antipyretic effect; it has a strong antibacterial effect on Staphylococcus aureus; its methanol extract has certain analgesic and anti-inflammatory effects.
  • Peony seed oil also known as peony oil
  • peony oil is made from peony seeds and is processed through squeezing or other extraction techniques. The final product is made through a series of extraction processes.
  • hyaluronidase inhibition According to the chemical composition of hyaluronidase inhibition, it can be roughly divided into polysaccharides, proteins, alkaloids, terpenes, etc.
  • traditional Chinese medicine extracts also include oil-soluble components such as volatile oils and lignans. To date, there have been no reports of hyaluronidase inhibitory activity among these oil-soluble ingredients.
  • the present invention unexpectedly found that compounding Artemisia annua extract and oil-soluble components (for example, oil-soluble components such as Schizonepeta sapiens and peony seed oil) has an excellent hyaluronidase inhibitory effect. Therefore, a composition containing artemisia annua extract and oil-soluble ingredients can be added as a compound functional additive to external skin preparations to assist in relieving itching, eczema, etc.
  • oil-soluble components for example, oil-soluble components such as Schizonepeta sapiens and peony seed oil
  • the present invention provides the application of a composition comprising an Artemisia annua extract and an oil-soluble component in skin anti-allergy, anti-inflammation and/or anti-irritation, wherein the oil-soluble component is selected from the group consisting of Schizonepeta sapiens extract and an oil-soluble component. Peony seed oil.
  • the Artemisia annua extract is prepared by ultrasonic extraction. In a preferred embodiment, the Artemisia annua extract is extracted using water as a solvent.
  • the oil-soluble component is Schizonepeta parsnip extract, and the weight ratio of Artemisia annua extract to Schizonepeta sapiens extract is 4:1 to 30:1.
  • the oil-soluble component is peony seed oil, and the weight ratio of the Artemisia annua extract to the peony seed oil is 3:1 to 33:1.
  • the anti-inflammatory, anti-allergic and/or anti-irritant effects are achieved by inhibiting hyaluronidase; or used to assist in relieving itching and/or eczema problems.
  • the present invention provides the use of a composition comprising an Artemisia annua extract and an oil-soluble component in the preparation of a skin external preparation with skin anti-allergic, anti-inflammatory and/or anti-irritant effects, wherein the oil-soluble component Selected from Nepeta parsnip extract and peony seed oil.
  • the external skin agent is selected from the group consisting of: cream, lotion, gel, lotion, essence, facial mask, eye cream, aerosol cleansing foam, spray, shower gel, and facial cleanser.
  • Figure 1 shows the results of the positive control hyaluronidase inhibition experiment.
  • Figure 2 shows the results of the hyaluronidase inhibition experiment of Example 2.
  • Figure 3 shows the results of the hyaluronidase inhibition experiment in Example 3.
  • Figure 4 shows the results of the hyaluronidase inhibition experiment of Example 4.
  • Figure 5 shows the results of the hyaluronidase inhibition experiment of Example 5.
  • Figure 6 shows the results of the hyaluronidase inhibition experiment of Example 6.
  • Figure 7 shows the results of the hyaluronidase inhibition experiment of Example 7.
  • Figure 8 shows the results of the hyaluronidase inhibition experiment of Example 8.
  • Figure 9 shows the results of the hyaluronidase inhibition experiment of Example 9.
  • Figure 10 shows the results of the hyaluronidase inhibition experiment of Example 10.
  • the object of the present invention is to provide a composition containing Artemisia annua extract and oil-soluble components. Specifically, the combination of Artemisia annua extract and oil-soluble ingredients has a better effect on inhibiting hyaluronidase. Therefore, the composition containing Artemisia annua extract and oil-soluble ingredients can be added to skin care products as a compound functional additive to help relieve itching, eczema, etc.
  • Artemisia annua L. is the whole plant of Artemisia annua L. in the Asteraceae family. Bitter and cold in nature. Returns to the liver, gallbladder, and kidney meridians. It has the effect of clearing away heat, relieving heat and cutting off malaria.
  • Artemisia annua contains the anti-malarial ingredient artemisinin, which can directly kill malaria parasites.
  • Artemisia annua extract has antibacterial and insecticidal, antipyretic and anti-inflammatory, and immune-regulating effects. It also has five types of antioxidant activity. Flavonoids, including quercetin, etc.
  • an ultrasonic extraction method is used to extract the Artemisia annua extract.
  • Ultrasonic extraction characteristics Including: 1. Shorten the extraction time, each ultrasound only takes 20min-30min, and conventional extraction is basically 1h-1.5h; 2. Extraction at room temperature, without destroying heat-sensitive components; 3. Direct cell wall breaking, and the active ingredients are more completely extracted.
  • the process parameters of ultrasonic extraction are as follows: extraction twice, 20 minutes each time, ultrasonic for 3 seconds, and gap of 3 seconds.
  • the extraction solvent is water (eg, deionized water).
  • the extraction process includes an alcohol precipitation step. For example, 95% ethanol is used to achieve alcohol precipitation.
  • the extraction process includes a filtering step.
  • the extraction process includes a centrifugation step.
  • the extraction process also includes a concentration step. For example, concentrate to a solid content of 5-20% by weight. In a specific embodiment, the solid content is concentrated to 10.94% by weight.
  • the present invention unexpectedly found that the compounding of artemisia annua extract and oil-soluble ingredients (such as Schizonepeta parsnip extract and peony seed oil) has a better synergistic effect on skin anti-sensitivity, anti-inflammation and/or anti-irritation. Therefore, Artemisia annua extract can be used in combination with oil-soluble ingredients to achieve anti-allergic, anti-inflammatory and/or anti-irritant effects on the skin.
  • oil-soluble ingredients such as Schizonepeta parsnip extract and peony seed oil
  • the functional extract is Nepeta parsnip extract.
  • the Schizonepeta parsnip extract is prepared using a supercritical extraction method. For example, it can be prepared using the HA220-50-06 supercritical extraction equipment of Jiangsu Nantong Huaan Supercritical Extraction Co., Ltd.
  • the preparation of the Nepeta parsnip extract further includes a re-dissolving step. For example, absolute ethanol is used to achieve redissolution.
  • the preparation of the Nepeta parsnip extract further includes a concentration step.
  • the extract can be concentrated to an infusion.
  • the preparation of the Schizonepeta parsnip extract further includes the step of adding anhydrous sodium sulfate.
  • the preparation of Nepeta parsnip extract further includes a filtration step.
  • cotton absorbent cotton ordinary grade, Shanghai Honglong
  • the preparation of the Nepeta parsnip extract further includes an elution step.
  • rice bran oil is used to achieve elution.
  • Rice bran oil is a type of base oil.
  • the preparation of Nepeta parsnip extract further includes The step of adding Tween 20 and pH 3.5 acetic acid-sodium acetate buffer (i.e. Buffer buffer). Oil-soluble ingredients will stratify when they meet water, so suspending agents (such as Tween) are often added during preparation to make them into suspensions to ensure that the experiment can proceed normally. Generally, the amount of Tween added is 10%. In a specific embodiment of the present invention, the Schizonepeta parsnip oil extract is finally formulated to have a solid content of 1%.
  • the present invention provides a composition comprising an extract of Artemisia annua and an extract of Schizonepeta parsnip, wherein the weight ratio of the Artemisia annua extract to the Schizonepeta sapiens extract is 4:1 to 30:1. In a preferred embodiment, the weight ratio of the Artemisia annua extract to the Schizonepeta parsnip extract is 10:1 to 30:1. In a preferred embodiment, the weight ratio of the Artemisia annua extract to the Schizonepeta parsnip extract is 10:1 to 25:1.
  • the functional extract is peony seed oil.
  • Peony seed oil also known as peony oil, is made from peony seeds as raw materials, and is finally made through a series of extraction processes by pressing or other extraction techniques.
  • the peony seed oil provided by Heze Hi-Tech Peony Application Research Institute is used. Oil-soluble ingredients will stratify when they meet water, so suspending agents (such as Tween) are often added during preparation to make them into suspensions to ensure that the experiment can proceed normally. Generally, the amount of Tween added is 10%.
  • the present invention provides a composition comprising artemisia annua extract and peony seed oil, wherein the weight ratio of artemisia annua extract and peony seed oil is 3:1 to 33:1. In a preferred embodiment, the weight ratio of Artemisia annua extract to peony seed oil is 10:1 to 33:1.
  • composition comprising artemisia annua extract and oil-soluble components of the present invention can be used as a compound functional additive in external skin preparations.
  • the external skin agent is selected from: facial cleanser, lotion, lotion, cream, gel, and facial mask. Different dosages are added according to different types of preparations.
  • an external preparation for skin which includes a composition of an Artemisia annua extract and an oil-soluble component and an excipient acceptable in the field of cosmetics.
  • the external agent for skin is a general term for all ingredients commonly used on the outside of the skin, and may be, for example, a cosmetic composition or a pharmaceutical composition.
  • the cosmetic composition may include basic cosmetics, facial makeup cosmetics, body cosmetics, hair care cosmetics, etc. There are no special restrictions on the dosage form and can be selected appropriately according to different purposes.
  • the cosmetic composition also contains different cosmetically acceptable media or matrix excipients depending on the dosage form and purpose.
  • Topical skin preparations contain a dermatologically acceptable carrier or vehicle (e.g., lotions, creams, soft ointments, detergents, etc.).
  • a dermatologically acceptable carrier or vehicle e.g., lotions, creams, soft ointments, detergents, etc.
  • a carrier capable of dissolving or dispersing these components at the concentrations described above based on common knowledge in the art.
  • a carrier When a carrier is used, it should not cause inactivation of the Artemisia annua extract or oil-soluble ingredients and should not cause any adverse effects on the skin when used.
  • the skin external preparation of the present invention may be in the form of a topical application product, which can be applied externally to the skin, and can be prepared by those ordinary techniques known in the art.
  • the carrier may take various practical forms, such as creams, dressings, gels, lotions, ointments or liquids, which comprise the composition for application and cleansing, and they may be added to, for example, dry or A wet applicator, hydrogel matrix, or adhesive (or non-adhesive) patch material carrier.
  • the carrier is a gel or moisturizing lotion, or an application in dry or wet form.
  • Typical carriers include emulsions containing water and/or alcohol and an emollient, such as hydrocarbon oils and waxes, silicone oils, hyaluronic acid, vegetable, animal or marine fats or oils, glyceride derivatives, Fatty acids, or fatty acid esters or alcohols or alcohol ethers, lanolin and its derivatives, polyols or esters, wax esters, sterols, phospholipids, etc., generally emulsifiers (nonionic, cationic or anionic), Although some emollients have emulsifying properties of their own. Additionally, these same components may be formulated into creams, gels, or solid sticks using different ratios of their components and/or by incorporating thickening agents such as gums or other forms of hydrophilic colloids.
  • an emollient such as hydrocarbon oils and waxes, silicone oils, hyaluronic acid, vegetable, animal or marine fats or oils, glyceride derivatives, Fatty acids
  • the skin external preparation of the present invention may contain additional components commonly found in skin care compositions, such as emollients, skin conditioners, emulsifiers, preservatives, antioxidants, fragrances, chelating agents, etc., as long as they are compatible with the skin.
  • additional components commonly found in skin care compositions, such as emollients, skin conditioners, emulsifiers, preservatives, antioxidants, fragrances, chelating agents, etc., as long as they are compatible with the skin.
  • the other components of the topical preparation are physically and chemically compatible.
  • one or more preservatives may be used. Suitable preservatives include parahydroxyacetophenone, C1-C4 alkyl parabens and phenoxyethanol.
  • the preservative is present in an amount of from about 0.5 to about 2% by weight, preferably from about 0.5 to 1% by weight, based on the total weight of the composition.
  • one or more antioxidants may be used. Suitable antioxidants include butylated hydroxytoluene (BHT), ascorbyl palmitate (BHA), butylated hydroxyaniline Ether, phenyl-alpha-naphthylamine, hydroquinone, propyl gallate, nordihydroguaiaretic acid, vitamin E or derivatives of vitamin E, vitamin C and its derivatives, calcium pantothenate, green tea extract and Mixed polyphenols, and mixtures of the substances mentioned above.
  • the antioxidant is used in an amount ranging from about 0.02 to 0.5% by weight, more most preferably from about 0.002 to 0.1% by weight, based on the total weight of the composition.
  • one or more emollients may be used that act as a lubricant to reduce flaking by their ability to remain on the skin surface or in the stratum corneum, Improves the appearance of skin.
  • Typical emollients include fatty esters, fatty alcohols, mineral oils, polyethersiloxane copolymers, and the like.
  • emollients include, without limitation, polypropylene glycol ("PPG")-15 octadecyl ether, PPG-10 cetyl ether, Steareth-10, Oleth-8, PPG-4 dodecane Ether, vitamin E acetate, lanolin, cetyl alcohol, cetearyl ethyl hexanoate, cetostearyl alcohol, glyceryl stearate, octyl hydroxystearate, dimethylpolysiloxane alkanes, and their combinations. Cetyl alcohol, cetearyl ethylhexanoate, cetearyl alcohol, glycerol stearate and combinations thereof are preferred.
  • the emollient may be present in an amount ranging from about 0.1 to about 30%, preferably from about 1 to about 30% by weight, based on the total weight of the composition.
  • one or more humectants may be used.
  • Moisturizers are also called humectants, which help to increase the effectiveness of emollient, reduce flaking, stimulate the removal of flaky skin and improve skin feel.
  • Polyols can be used as humectants, including but not limited to, glycerin, polyalkylene glycols, alkylene polyols and their derivatives, including butylene glycol, propylene glycol, dipropylene glycol, polyglycerol, polyethylene glycol Alcohols and their derivatives, sorbitol, hydroxypropyl sorbitol, hexanediol, 1,3-dibutanediol, 1,2,6-hexanetriol, ethoxylated glycerin, propoxylated glycerin, and their combinations.
  • the humectant is present in an amount from about 0.1 to about 20% by weight, preferably from about 1 to about 15% by weight, based on the total weight of the composition.
  • one or more emulsifiers may be used.
  • Emulsifiers can be used within an effective stabilizing amount.
  • the emulsifier is used in an amount from about 1.0 to about 10.0% by weight, more preferably from about 3.0 to about 6.0% by weight, based on the total weight of the composition.
  • Any emulsifier compatible with the components of the composition may be used.
  • Suitable emulsifiers include stearic acid, cetyl alcohol, glyceryl stearate, lecithin, stearyl alcohol, Steareth-2, Steareth-20, acrylic/C10-30 alkanol acrylate cross-links Polymers, and their combinations.
  • one or more pH adjusters may be used.
  • Useful pH adjusters in the skin external preparations of the present invention include tromethamine.
  • the pH adjuster is present in an amount of from about 0.1 to about 2% by weight, preferably from about 0.1 to about 1% by weight, based on the total weight of the composition.
  • the skin external preparation includes acrylic/C10-30 alkanol acrylate crosspolymer, glycerin, p-hydroxyacetophenone, glyceryl stearate and lecithin, /stearyl alcohol, cetearyl ethylhexanoate, tromethamine or combinations thereof.
  • the dosage of the composition of Artemisia annua extract and oil-soluble ingredients in the external skin preparation is 0.001%-0.2% (w/w), and the preferred weight percentage is 0.007%-0.1% (w /w), the more preferred weight percentage is 0.007%-0.08% (w/w), and the most preferred weight percentage is 0.007%-0.056% (w/w).
  • Buffer buffer acetic acid-sodium acetate buffer
  • potassium tetraborate (national medicine reagent, analytical grade) and use 250ml of water to prepare a 0.4mol/L potassium borate solution for later use.
  • T is the sample
  • T0 is the sample control
  • C is the blank
  • C0 is the blank control
  • IC50 ⁇ 10 mg/ml is excellent, IC50 ⁇ 30 mg/ml is good, IC50 ⁇ 50 mg/ml is average, and IC50 ⁇ 50 mg/ml has basically no application value.
  • the extract of Example 2 has a certain ability to inhibit hyaluronidase as a single drug
  • the extract of Example 3 has no ability to inhibit hyaluronidase
  • the extract of Example 4 has a weak ability to inhibit hyaluronidase.
  • the ability to inhibit hyaluronic acid is improved to a certain extent. force.
  • Example 5 the compound ratio of Artemisia annua extract and Schizonepeta parsnip oil in Example 5 is 1:1, and the compound ratio of Artemisia annua extract and Schizonepeta parsnip oil in Example 7 is 1:1.
  • the oil compounding ratio is 7:3.
  • the IC 50 concentrations are greater than the IC 50 concentrations of the positive control sodium cromoglycate, they are still less than the single drug.
  • Example 5 is preferred, and Example 7 is second preferred.
  • the preparations of Examples 5-10 can be used in the preparation of external preparations for skin.
  • the skin external preparation is preferably a cosmetic composition, such as lotion, essence, cream, etc.
  • the weight percentage of the preparation in the skin external preparation is 0.08%-1% (w/w).
  • the preferred weight percentage is 0.12%-0.64% (w/w).
  • a more preferred weight percentage is 0.24%-0.5% (w/w).
  • the most preferred weight percentage is 0.32%-0.48% (w/w).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne l'utilisation d'une composition contenant un extrait d'Artemisia annua L. et un composant soluble dans l'huile dans l'anti-allergie cutanée, l'anti-inflammation et/ou l'anti-irritation, le composant soluble dans l'huile étant choisi parmi un extrait d'Herba Schizonepetae-Radix Saposhnikoviae et une huile de graines de pivoine. La présente invention concerne également une utilisation d'une composition contenant un extrait d'Artemisia annua L. et un composant soluble dans l'huile dans la préparation d'une préparation externe pour la peau présentant un effet anti-allergie, anti-inflammation et/ou anti-irritation de la peau, le composant soluble dans l'huile étant choisi parmi un extrait d'Herba Schizonepetae-Radix Saposhnikoviae et une huile de graines de pivoine.
PCT/CN2023/106478 2022-07-15 2023-07-10 Composition contenant un extrait d'artemisia annua l. et un composant soluble dans l'huile, et son utilisation WO2024012386A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202210836216.6 2022-07-15
CN202210836216.6A CN117427006A (zh) 2022-07-15 2022-07-15 包含青蒿提取物和油溶性成分的组合物及其应用

Publications (1)

Publication Number Publication Date
WO2024012386A1 true WO2024012386A1 (fr) 2024-01-18

Family

ID=89535601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2023/106478 WO2024012386A1 (fr) 2022-07-15 2023-07-10 Composition contenant un extrait d'artemisia annua l. et un composant soluble dans l'huile, et son utilisation

Country Status (2)

Country Link
CN (1) CN117427006A (fr)
WO (1) WO2024012386A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114533647A (zh) * 2022-03-31 2022-05-27 广州旭妆生物科技有限公司 无硅油去屑洗发组合物及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114533647A (zh) * 2022-03-31 2022-05-27 广州旭妆生物科技有限公司 无硅油去屑洗发组合物及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
邓薇 等 (DENG, WEI ET AL.): "针对敏感性皮肤的中药应用概况 (Commonly used Traditional Chinese Medicine for Sensitive Skin)", 中国现代中药 (MODERN CHINESE MEDICINE), vol. 17, no. 1, 31 January 2015 (2015-01-31), XP055970980, DOI: 10.13313/j.issn.1673-4890.2015.1.022 *

Also Published As

Publication number Publication date
CN117427006A (zh) 2024-01-23

Similar Documents

Publication Publication Date Title
US20200129408A1 (en) Compositions using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications
US4593046A (en) Method of reducing skin irritation from benzoyl peroxide
KR20180036580A (ko) 수가용화(水加溶化)된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물
CN108186679B (zh) 一种祛痘组合物
EP1514536B1 (fr) Utilisation de compositions Topiques
HU218921B (hu) Stroncium (II) valamely szervetlen sója topikális alkalmazása neurogén eredetű bőrelváltozások kezelésére alkalmas gyógyszerkészítmények előállítására
JPH08245409A (ja) 皮膚外用剤及び浴用剤
WO2012099899A2 (fr) Compositions dermatologiques topiques destinées au traitement de l'acné
JP5765744B2 (ja) アトピー性皮膚炎の予防剤または治療剤、および外用剤
JP4583655B2 (ja) 抗アレルギー皮膚外用組成物
JPH0987188A (ja) 皮膚外用剤及び浴用剤
EP2306999B1 (fr) Compositions pour traiter la rosacée comprenants du chitosane et un amide dicarboxylique
WO2024012386A1 (fr) Composition contenant un extrait d'artemisia annua l. et un composant soluble dans l'huile, et son utilisation
WO2024012387A1 (fr) Composition comprenant un extrait d'armoise annuelle et un composant soluble dans l'eau, et son utilisation
WO2024012385A1 (fr) Composition comprenant un extrait d'artemisiae annuae herba et une substance active fonctionnelle et son utilisation
HU218946B (hu) Stroncium (II) valamely szervetlen sója topikális alkalmazása szemviszketés, szem- és/vagy szemhéjfájdalmak és szem- és/vagy szemhéjérzékenység kezelésére alkalmas gyógyszerkészítmények előállítására
KR100892742B1 (ko) 여드름 치료용 피부 외용제 조성물
JP2007045734A (ja) 皮膚外用剤およびヒアルロニダーゼ阻害剤
WO2019233158A1 (fr) Composition de gel de médecine chinoise traditionnelle, son procédé de préparation et son utilisation
JP6853406B1 (ja) 抗毛嚢炎用外用組成物
EP4059508A1 (fr) Procédés d'utilisation de compositions comprenant un extrait de lichen d'islande
JP2003238328A (ja) 低刺激性皮膚外用剤
JP2004107261A (ja) 皮膚老化抑制化粧料
JP2003183113A (ja) 外用組成物
WO2003080096A1 (fr) Compositions de traitement et/ou de prevention de la pollinose

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23838878

Country of ref document: EP

Kind code of ref document: A1