WO2024012385A1 - Composition comprenant un extrait d'artemisiae annuae herba et une substance active fonctionnelle et son utilisation - Google Patents

Composition comprenant un extrait d'artemisiae annuae herba et une substance active fonctionnelle et son utilisation Download PDF

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Publication number
WO2024012385A1
WO2024012385A1 PCT/CN2023/106475 CN2023106475W WO2024012385A1 WO 2024012385 A1 WO2024012385 A1 WO 2024012385A1 CN 2023106475 W CN2023106475 W CN 2023106475W WO 2024012385 A1 WO2024012385 A1 WO 2024012385A1
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artemisia annua
skin
active substance
extract
functional active
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PCT/CN2023/106475
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English (en)
Chinese (zh)
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陈默
孙懿
赵亚
贾海东
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上海家化联合股份有限公司
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Publication of WO2024012385A1 publication Critical patent/WO2024012385A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Definitions

  • the invention belongs to the field of phytochemistry, and specifically relates to a composition containing an Artemisia annua extract and functional active substances and its application in external skin agents or cosmetics.
  • Allergic reactions can be divided into types I, II, III, and IV according to their mechanisms, and hyaluronidase is a participant in type I allergic reactions and has a strong correlation with inflammation and allergy.
  • Hyaluronidase is a specific cleavage enzyme of hyaluronic acid, and hyaluronic acid displays a variety of physiological functions of traditional Chinese medicine in the body, such as moisturizing and promoting wound healing. According to research reports, some anti-allergic and anti-inflammatory drugs strongly inhibit hyaluronidase activity. Therefore, inhibition of hyaluronidase activity is used as an indicator to study anti-inflammatory effects.
  • Artemisia annua is the whole plant of Artemisia annua L. in the Asteraceae family. Bitter and cold in nature. Returns to the liver, gallbladder, and kidney meridians. It has the effect of clearing away heat, relieving heat and cutting off malaria.
  • Artemisia annua contains the anti-malarial component artemisinin, which can directly kill malaria parasites.
  • Artemisia annua extract has antibacterial and insecticidal, antipyretic and anti-inflammatory, and immune-regulating effects. It also has five kinds of flavonoids with antioxidant activity. Ingredients, including quercetin, etc.
  • dipotassium glycyrrhizate is an organic compound, which is a white or off-white fine powder. It has multiple functions such as antibacterial, anti-inflammatory, detoxification, anti-allergy, and deodorization. It is widely used in medicine, daily chemicals, and food. and other industries.
  • the currently more commonly used production process of dipotassium glycyrrhizate is to extract glycyrrhizic acid from licorice, use ammonia to produce monoammonium glycyrrhizate, and then produce dipotassium glycyrrhizate through ion exchange.
  • dipotassium glycyrrhizate can penetrate deep into the skin. It maintains high internal activity, whitens and is highly effective in antioxidants. It effectively inhibits the activity of various enzymes in the melanin production process, especially inhibits the activity of tyrosinase. It also has anti-rough skin and anti-inflammatory and antibacterial effects.
  • Bisabolol is also an organic compound. It is a non-toxic sesquiterpene alcohol found in natural essential oils. As an active ingredient, it is mainly used in skin protection and care cosmetics to protect and care for allergic skin. For skin, studies have shown that bisabolol not only has anti-inflammatory effects, but also has certain inhibitory activities. By effectively inhibiting the production of peroxidase, bisabolol has good inhibition on acute inflammation or chronic inflammation. Three-dimensional skin models have proven that bisabolol can inhibit the release of leukotrienes and interleukins caused by phorbol esters, thereby reducing the stimulation of human skin by external factors and ultraviolet rays, and preventing and inhibiting the occurrence and treatment of inflammation.
  • the present invention unexpectedly discovered that the compounding of Artemisia annua extract and functional active substances (for example, dipotassium glycyrrhizinate, bisabolol) has excellent hyaluronidase inhibitory effect. Therefore, the composition containing Artemisia annua extract and functional active substances can be added to skin external preparations as a compound functional additive to assist in relieving itching, eczema, etc.
  • functional active substances for example, dipotassium glycyrrhizinate, bisabolol
  • composition comprising an Artemisia annua extract and a functional active substance in skin anti-sensitivity, anti-inflammation and/or anti-irritation
  • the functional active substance is selected from the group consisting of dipotassium glycyrrhizinate and myrrh. alcohol.
  • the Artemisia annua extract is prepared by ultrasonic extraction. In a preferred embodiment, the Artemisia annua extract is extracted using water as a solvent.
  • the functional active substance is dipotassium glycyrrhizinate
  • the weight ratio of the Artemisia annua extract to dipotassium glycyrrhizinate is 1:10 to 10:1.
  • the functional active substance is bisabolol
  • the weight ratio of the Artemisia annua extract to bisabolol is 2:1 to 55:1.
  • the anti-inflammatory, anti-allergic and/or anti-irritant effects are achieved by inhibiting hyaluronidase; or used to assist in relieving itching and/or eczema problems.
  • the present invention provides the use of a composition comprising an Artemisia annua extract and a functional active substance in the preparation of a skin external preparation with skin anti-allergic, anti-inflammatory and/or anti-irritating effects, wherein the functional active substance Selected from dipotassium glycyrrhizinate and bisabolol.
  • the external skin agent is selected from the group consisting of: cream, lotion, gel, lotion, essence, facial mask, eye cream, aerosol cleansing foam, spray, shower gel, and facial cleanser.
  • Figure 1 shows the results of the positive control hyaluronidase inhibition experiment.
  • Figure 2 shows the results of the hyaluronidase inhibition experiment of Example 2.
  • Figure 3 shows the results of the hyaluronidase inhibition experiment in Example 3.
  • Figure 4 shows the results of the hyaluronidase inhibition experiment of Example 4.
  • Figure 5 shows the results of the hyaluronidase inhibition experiment of Example 6.
  • Figure 6 shows the results of the hyaluronidase inhibition experiment of Example 7.
  • Figure 7 shows the results of the hyaluronidase inhibition experiment of Example 8.
  • Figure 8 shows the results of the hyaluronidase inhibition experiment of Example 9.
  • Figure 9 shows the results of the hyaluronidase inhibition experiment of Example 10.
  • Figure 10 shows the results of the hyaluronidase inhibition experiment of Example 11.
  • the object of the present invention is to provide a composition containing Artemisia annua extract and functional active substances.
  • the combination of Artemisia annua extract and functional active substances has a better effect of inhibiting hyaluronidase. Therefore, the composition containing Artemisia annua extract and functional active substances can be added to skin care products as a compound functional additive to help relieve itching, eczema, etc.
  • Artemisia annua L. is the whole plant of Artemisia annua L. in the Asteraceae family. Bitter and cold in nature. Returns to the liver, gallbladder, and kidney meridians. It has the effect of clearing away heat, relieving heat and cutting off malaria.
  • Artemisia annua contains the anti-malarial ingredient artemisinin, which can directly kill malaria parasites.
  • Artemisia annua extract has antibacterial and insecticidal, antipyretic and anti-inflammatory, and immune-regulating effects. It also has five types of antioxidant activity. Flavonoids, including quercetin, etc.
  • an ultrasonic extraction method is used to extract the Artemisia annua extract.
  • Ultrasonic extraction characteristics Including: 1. Shorten the extraction time, each ultrasound only takes 20min-30min, and conventional extraction is basically 1h-1.5h; 2. Extraction at room temperature, without destroying heat-sensitive components; 3. Direct cell wall breaking, and the active ingredients are more completely extracted.
  • the process parameters of ultrasonic extraction are as follows: extraction twice, 20 minutes each time, ultrasonic for 3 seconds, and gap of 3 seconds.
  • the extraction solvent is water (eg, deionized water).
  • the extraction process includes an alcohol precipitation step. For example, 95% ethanol is used to achieve alcohol precipitation.
  • the extraction process includes a filtering step.
  • the extraction process includes a centrifugation step.
  • the extraction process also includes a concentration step. For example, concentrate to a solid content of 5-20% by weight. In a specific embodiment, the solid content is concentrated to 10.94% by weight.
  • the present invention unexpectedly found that the combination of Artemisia annua extract and functional active substances (such as dipotassium glycyrrhizinate or bisabolol) has a better synergistic effect in skin anti-sensitivity, anti-inflammation and/or anti-irritation. Therefore, Artemisia annua extract can be used in combination with functional actives to achieve skin anti-sensitivity, anti-inflammatory and/or anti-irritation effects.
  • functional active substances such as dipotassium glycyrrhizinate or bisabolol
  • the efficacy extract is dipotassium glycyrrhizinate.
  • Dipotassium glycyrrhizinate is an organic compound with multiple functions such as antibacterial, anti-inflammatory, detoxification, anti-allergic, and deodorant. It is widely used in medicine, daily chemicals, food and other industries. In the field of cosmetics, dipotassium glycyrrhizinate can penetrate deep into the skin and maintain high activity, whiten and effectively resist oxidation. It can effectively inhibit the activity of various enzymes in the melanin production process, especially inhibit the activity of tyrosine enzyme, and also prevent skin roughness. and anti-inflammatory and antibacterial effects.
  • the present invention provides a composition comprising Artemisia annua extract and dipotassium glycyrrhizinate, wherein the weight ratio of Artemisia annua extract to dipotassium glycyrrhizinate is 1:10 to 10:1. In a preferred embodiment, the weight ratio of Artemisia annua extract to dipotassium glycyrrhizinate is 2:5 to 5:2. In a preferred embodiment, the weight ratio of Artemisia annua extract to dipotassium glycyrrhizinate is 8:5 to 10:1.
  • the efficacy extract is bisabolol.
  • Bisabolol is an organic compound that protects and cares for allergic skin. Research shows that bisabolol not only has anti-inflammatory effects, but also has certain inhibitory activities. By effectively inhibiting the production of peroxidase, bisabolol has good inhibition on acute inflammation or chronic inflammation. Three-dimensional skin models have proven that bisabolol can inhibit the release of leukotrienes and interleukins caused by phorbol esters, thereby reducing the stimulation of human skin by external factors and ultraviolet rays, and preventing and inhibiting the occurrence and treatment of inflammation.
  • Bisabolol is an oil-soluble ingredient, oil-soluble ingredient It will stratify when exposed to water, so suspending agents (such as Tween) are often added during preparation to make it a suspension to ensure that the experiment can proceed normally. Generally, the amount of Tween added is 10%.
  • the present invention provides a composition comprising an Artemisia annua extract and bisabolol, wherein the weight ratio of an Artemisia annua extract to bisabolol is 1:10 to 10:1.
  • the weight ratio of Artemisia annua extract to bisabolol is 1:5 to 5:1.
  • the weight ratio of Artemisia annua extract to bisabolol is 2:1 to 55:1.
  • the weight ratio of Artemisia annua extract to bisabolol may be 10.94:5, 10.94:1 or 54.7:1.
  • composition comprising artemisia annua extract and functional active substances of the present invention can be used as a composite functional additive in external skin preparations.
  • the external skin agent is selected from: facial cleanser, lotion, lotion, cream, gel, and facial mask. Different dosages are added according to different types of preparations.
  • an external skin preparation which includes a composition of Artemisia annua extract and functional active substances and excipients acceptable in the field of cosmetics.
  • the external agent for skin is a general term for all ingredients commonly used on the outside of the skin, and may be, for example, a cosmetic composition or a pharmaceutical composition.
  • the cosmetic composition may include basic cosmetics, facial makeup cosmetics, body cosmetics, hair care cosmetics, etc. There are no special restrictions on the dosage form and can be selected appropriately according to different purposes.
  • the cosmetic composition also contains different cosmetically acceptable media or matrix excipients depending on the dosage form and purpose.
  • Dermal topicals contain dermatologically acceptable carriers or vehicles (eg, lotions, creams, ointments, cleansers, etc.). Those of ordinary skill in the art can select a carrier capable of dissolving or dispersing these components at the concentrations described above based on common knowledge in the art. When a carrier is used, it should not cause inactivation of the Artemisia annua extract or functional active and should not cause any adverse effects on the skin when used.
  • dermatologically acceptable carriers or vehicles eg, lotions, creams, ointments, cleansers, etc.
  • the skin external preparation of the present invention may be in the form of a topical application product, which can be externally applied to the skin, and can be prepared by those ordinary techniques known in the art.
  • Carriers can take a variety of physical forms Formulas, such as creams, dressings, gels, lotions, ointments or liquids, which include compositions that are applied and rinsed off, and their addition to, for example, dry or wet applications, hydrogels, using methods well known in the art.
  • Glue matrix, or material carrier for an adhesive (or non-adhesive) patch is a gel or moisturizing lotion, or an application in dry or wet form.
  • Typical carriers include emulsions containing water and/or alcohol and an emollient, such as hydrocarbon oils and waxes, silicone oils, hyaluronic acid, vegetable, animal or marine fats or oils, glyceride derivatives, Fatty acids, or fatty acid esters or alcohols or alcohol ethers, lanolin and its derivatives, polyols or esters, wax esters, sterols, phospholipids, etc., generally emulsifiers (nonionic, cationic or anionic), Although some emollients have emulsifying properties of their own. Additionally, these same components may be formulated into creams, gels, or solid sticks using different ratios of their components and/or by incorporating thickening agents such as gums or other forms of hydrophilic colloids.
  • an emollient such as hydrocarbon oils and waxes, silicone oils, hyaluronic acid, vegetable, animal or marine fats or oils, glyceride derivatives, Fatty acids
  • the skin external preparation of the present invention may contain additional components commonly found in skin care compositions, such as emollients, skin conditioners, emulsifiers, preservatives, antioxidants, fragrances, chelating agents, etc., as long as they are compatible with the skin.
  • additional components commonly found in skin care compositions, such as emollients, skin conditioners, emulsifiers, preservatives, antioxidants, fragrances, chelating agents, etc., as long as they are compatible with the skin.
  • the other components of the topical preparation are physically and chemically compatible.
  • one or more preservatives may be used. Suitable preservatives include parahydroxyacetophenone, C1-C4 alkyl parabens and phenoxyethanol.
  • the preservative is present in an amount of from about 0.5 to about 2% by weight, preferably from about 0.5 to 1% by weight, based on the total weight of the composition.
  • one or more antioxidants may be used. Suitable antioxidants include butylated hydroxytoluene (BHT), ascorbyl palmitate (BHA), butylated hydroxyanisole, phenyl-alpha-naphthylamine, hydroquinone, propyl gallate, nordihydroguaiaretic acid , vitamin E or derivatives of vitamin E, vitamin C and its derivatives, calcium pantothenate, green tea extract and mixed polyphenols, and mixtures of the above mentioned substances.
  • BHT butylated hydroxytoluene
  • BHA ascorbyl palmitate
  • butylated hydroxyanisole phenyl-alpha-naphthylamine
  • hydroquinone propyl gallate
  • nordihydroguaiaretic acid a antioxidant that is used in an amount ranging from about 0.02 to 0.5% by weight, more most preferably from about 0.002 to 0.1% by weight, based on the total weight of the composition.
  • one or more emollients may be used that act as a lubricant to reduce flaking by their ability to remain on the skin surface or in the stratum corneum, Improves the appearance of skin.
  • Typical emollients include fatty esters, fatty alcohols, mineral oils, polyethersiloxane copolymers, and the like.
  • emollients include, without limitation, polypropylene glycol ("PPG")-15 octadecyl ether, PPG-10 cetyl ether, Steareth-10, Oleth-8, PPG-4 dodecane base ether, vitamin E acetate, lanolin, cetyl alcohol, cetearyl ethylhexanoate, cetearyl alcohol, glyceryl stearate, octyl hydroxystearate, dimethylpolysiloxane, and the like The combination. Cetyl alcohol, cetearyl ethylhexanoate, cetearyl alcohol, glycerol stearate and combinations thereof are preferred. When used, the emollient may be present in an amount ranging from about 0.1 to about 30%, preferably from about 1 to about 30% by weight, based on the total weight of the composition.
  • one or more humectants may be used.
  • Moisturizers are also called humectants, which help to increase the effectiveness of emollient, reduce flaking, stimulate the removal of flaky skin and improve skin feel.
  • Polyols can be used as humectants, including but not limited to, glycerin, polyalkylene glycols, alkylene polyols and their derivatives, including butylene glycol, propylene glycol, dipropylene glycol, polyglycerol, polyethylene glycol Alcohols and their derivatives, sorbitol, hydroxypropyl sorbitol, hexanediol, 1,3-dibutanediol, 1,2,6-hexanetriol, ethoxylated glycerin, propoxylated glycerin, and their combinations.
  • the humectant is present in an amount from about 0.1 to about 20% by weight, preferably from about 1 to about 15% by weight, based on the total weight of the composition.
  • one or more emulsifiers may be used.
  • Emulsifiers can be used within an effective stabilizing amount.
  • the emulsifier is used in an amount from about 1.0 to about 10.0% by weight, more preferably from about 3.0 to about 6.0% by weight, based on the total weight of the composition.
  • Any emulsifier compatible with the components of the composition may be used.
  • Suitable emulsifiers include stearic acid, cetyl alcohol, glyceryl stearate, lecithin, stearyl alcohol, Steareth-2, Steareth-20, acrylic/C10-30 alkanol acrylate cross-links Polymers, and their combinations.
  • one or more pH adjusters may be used.
  • Useful pH adjusters in the skin external preparations of the present invention include tromethamine.
  • the pH adjuster is present in an amount of from about 0.1 to about 2% by weight, preferably from about 0.1 to about 1% by weight, based on the total weight of the composition.
  • the skin external preparation includes acrylic/C10-30 alkanol acrylate crosspolymer, glycerin, p-hydroxyacetophenone, glyceryl stearate and lecithin, /stearyl alcohol, cetearyl ethylhexanoate, tromethamine or combinations thereof.
  • the dosage of the composition of Artemisia annua extract and functional active substances in the external skin preparation is 0.001%-0.2% (w/w), and the preferred weight percentage is 0.007%-0.1% (w /w), the more preferred weight percentage is 0.007%-0.08% (w/w), the most preferred weight percentage is 0.007%-0.056%(w/w).
  • the Artemisia annua extract prepared in Example 1 with a solid content of 10.94% was added to deionized water to prepare a solution with a solid content of 4% for later use.
  • Example 5 Mix the extract of Example 5: the solution of Example 3 evenly at a weight ratio of 1:1 and set aside.
  • Example 4 Mix the extract of Example 1: the solution of Example 4 evenly at a weight ratio of 1:1 and set aside.
  • potassium tetraborate (national medicine reagent, analytical grade) and use 250ml of water to prepare a 0.4mol/L potassium borate solution for later use.
  • Example 2-11 Take the prepared extract or solution of Example 2-11, dilute it with buffer, conduct the test according to the method in Table 1, measure the absorbance value at 585 nm, and finally calculate its IC50.
  • T is the sample
  • T0 is the sample control
  • C is the blank
  • C0 is the blank control
  • Example 8 the compound ratio of Artemisia annua extract and dipotassium glycyrrhizinate in Example 8 is 5:2, and the compound ratio of Artemisia annua extract and dipotassium glycyrrhizinate in Example 7 is 5:2.
  • the potassium ratio is 2:5, and the IC 50 concentrations are all lower than the IC 50 concentration of the positive control sodium cromoglycate.
  • Example 8 is preferred, and Example 7 is the second preferred.
  • Example 11 the compound ratio of Artemisia annua extract and bisabolol in Example 11 is 5:1, and the compound ratio of Artemisia annua extract and bisabolol in Example 9 is 1:1.
  • IC 50 concentrations are both greater than The IC 50 concentration of sodium cromoglycate of the positive control is still lower than that of the single drug, so Example 11 is preferred, and Example 9 is second preferred.
  • the preparations of Examples 6 to 11 can be used for the preparation of external skin preparations.
  • the skin external preparation is preferably Selected as cosmetic compositions, such as lotions, essences, creams, etc.
  • the weight percentage of the preparation in the external skin preparation is 0.001%-0.2% (w/w).
  • the preferred weight percentage is 0.007%-0.1% (w/w).
  • a more preferred weight percentage is 0.007%-0.08% (w/w).
  • the most preferred weight percentage is 0.007%-0.056% (w/w).

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  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne l'utilisation d'une composition comprenant un extrait d'Artemisiae annuae herba et une substance active fonctionnelle dans la lutte contre les allergies cutanées, l'inflammation cutanée et/ou l'irritation cutanée, la substance active fonctionnelle étant choisie parmi le glycyrrhizinate dipotassique et le bisabolol. La présente invention concerne également l'utilisation d'une composition comprenant un extrait d'Artemisiae annuae herba et une substance active fonctionnelle dans la préparation d'une préparation topique pour la peau ayant les effets de lutter contre les allergies cutanées, l'inflammation cutanée et/ou l'irritation cutanée, la substance active fonctionnelle étant choisie parmi le glycyrrhizinate dipotassique et le bisabolol.
PCT/CN2023/106475 2022-07-15 2023-07-10 Composition comprenant un extrait d'artemisiae annuae herba et une substance active fonctionnelle et son utilisation WO2024012385A1 (fr)

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CN113855718A (zh) * 2021-09-30 2021-12-31 上海家化联合股份有限公司 青蒿提取物及其应用
CN116035986A (zh) * 2022-06-29 2023-05-02 广州凡岛网络科技有限公司 一种应用于化妆品配方中的头皮修复组合物

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* Cited by examiner, † Cited by third party
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CN105496904A (zh) * 2016-01-25 2016-04-20 王晶怡 一种过敏皮肤用的化妆水
CN110099678A (zh) * 2016-12-23 2019-08-06 欧莱雅 含有透明质酸和协同抗透明质酸酶活性剂的组合物
CN106726789A (zh) * 2017-03-14 2017-05-31 四川蓝伯特生物科技股份有限公司 一种青蒿抑菌沐浴露及其制备方法
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