WO2019233158A1 - Composition de gel de médecine chinoise traditionnelle, son procédé de préparation et son utilisation - Google Patents

Composition de gel de médecine chinoise traditionnelle, son procédé de préparation et son utilisation Download PDF

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Publication number
WO2019233158A1
WO2019233158A1 PCT/CN2019/078711 CN2019078711W WO2019233158A1 WO 2019233158 A1 WO2019233158 A1 WO 2019233158A1 CN 2019078711 W CN2019078711 W CN 2019078711W WO 2019233158 A1 WO2019233158 A1 WO 2019233158A1
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WO
WIPO (PCT)
Prior art keywords
chinese medicine
gel composition
gel
traditional chinese
weight
Prior art date
Application number
PCT/CN2019/078711
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English (en)
Chinese (zh)
Inventor
徐丽华
Original Assignee
苏州思源天然产物研发有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 苏州思源天然产物研发有限公司 filed Critical 苏州思源天然产物研发有限公司
Priority to JP2021517885A priority Critical patent/JP7440931B2/ja
Publication of WO2019233158A1 publication Critical patent/WO2019233158A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

  • the invention relates to the field of cosmetics, in particular to a traditional Chinese medicine gel composition, a preparation method thereof, and a mask prepared by using the gel composition.
  • the mask In the field of cosmetics, the mask has always been a commonly used skin care product. In recent years, more and more users are accustomed to using the mask for beauty care.
  • disposable masks which are usually applied before bedtime, which is more convenient and time-saving, and is popular. Among them, moisturizing and plant-based ingredients are more popular.
  • the beauty and beauty of traditional Chinese medicine is deeply rooted in people's hearts. People hope that the masks have the beauty effect of traditional Chinese medicine.
  • existing masks containing traditional Chinese medicine are usually added with a small amount of extracts or original medicinal powder.
  • the disposable cleansing mask usually has a single use amount of about 5g, and there are not many drugs or functional ingredients that can be carried.
  • the traditional Chinese medicine mask produced in this way has a small amount of active ingredients and lacks significant effects.
  • Hydrogel also known as hydrogel, is a hydrophilic network-like polymer swelling body that can swell in water, absorb and retain a large amount of water, but does not dissolve in water. It has solubility, syneresis, and permeability. Passive and sticky, it is a good drug carrier for slow release and transdermal absorption. Hydrogels are commonly used in the preparation of chemicals, and the drug loading is relatively large, up to about 5%. However, in the field of traditional Chinese medicine, due to its inaccurate preparation process and complex ingredients, there are many ingredients that can interfere with gel formation, especially a large number of acids and salts, which can cause interference with gel formation (see Research Progress in External Hydrogels, Gao Yan et al., Chinese Medicine Guide, Vol. 5, No.
  • hydrogels of traditional Chinese medicines are relatively low.
  • a hydrogel with a bubbling agent whose content is 15%.
  • the preparation is prepared as a dry powder and added with ceramic powder, a cross-linking agent, a cross-linking regulator and other ingredients. The manufacturing process requires equipment and control. Are both higher.
  • one aspect of the present invention provides a gel composition containing 30-98% by weight of a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is composed of a Chinese medicine decoction extract and essence
  • the traditional Chinese medicine comes from wild chrysanthemum, rose, white peony, angelica, safflower, ginseng, gardenia.
  • the polymer hydrogel is selected from the group consisting of carbomer, hypromellose, hydroxyethyl cellulose, and xanthan gum.
  • Preferred polymer hydrogels are selected from hydroxyethyl cellulose, carbomer, and hypromellose.
  • the surfactant is selected from the group consisting of Tween, sodium lauryl sulfate, and lecithin.
  • Preferred surfactants are selected from Tween and sodium dodecylsulfonate.
  • the composition may further contain cosmetically acceptable additives and carriers, which additives and carriers may be selected from humectants, fragrances, pigments, preservatives, excipients, foaming Agent, thickener, defoamer, etc., wherein the humectant may be glycerin, preferably glycerol is present at 1-10% by weight of the composition.
  • cosmetically acceptable additives and carriers may be selected from humectants, fragrances, pigments, preservatives, excipients, foaming Agent, thickener, defoamer, etc.
  • a method for preparing a gel composition according to the present invention which includes the steps:
  • the method before the preparation of the composition, further comprises the steps of extracting the Chinese medicinal material with 10-20 times the weight of water for 1-5 hours, and distilling and condensing to prepare the Chinese medicinal material essence.
  • the method further comprises the step of obtaining the ointment by distilling the remaining decoction, and the ointment is prepared by the following steps:
  • the macroporous resin is preferably a styrene skeleton resin.
  • it may be LSA-7, LSA-10, LSA-33, XDA-1, etc. of Xi'an Lanxiao Technology New Materials Co., Ltd.
  • the use of the gel composition of the present invention is disclosed for the preparation of a cosmetic product, preferably selected from a facial mask, a face cream, an emulsion, a body milk, a hand mask, a foot mask, and the like.
  • the method is easy to operate, has few auxiliary materials, high content of traditional Chinese medicine, and the formula contains more than 90% by weight of the traditional Chinese medicine solution and more than 30% by weight of the raw medicine.
  • Each 10g mask is equivalent to 3-9g of traditional Chinese medicine, that is, about 10g per gel. It is equivalent to using 3-9g of traditional Chinese medicine.
  • the gel composition can be made into a cosmetic composition for external use, such as a mask. Its advantages and improvements are:
  • the words “comprising” (and any form of “including” such as containing and containing), “having” (and any form of “having” such as “having” and “having” ), “Including” (and any form of “including” such as “enclosed” and “enclosed”) or “containing” (and any form of "containing” such as “included” and “including”) are included Being open or open does not exclude additional elements or method steps not mentioned. It is contemplated that any embodiment discussed in this specification can be implemented with any method or composition of the invention, and vice versa. In addition, the composition of the present invention can be used to implement the method of the present invention.
  • Chinese Chinese medicine refers to any literature or record or a traditional Chinese medicine with cosmetic effects known from the prior art, which is derived from roses, wild chrysanthemums, gardenia, angelica, angelica, safflower, ginseng and the like.
  • Those skilled in the art can understand that other Chinese medicinal materials can also be made into essences and creams by the methods described herein, and added to the gel composition, based on the contents of the present disclosure, especially the specific embodiments.
  • Chinese herbal essential oils have the effect of moisturizing the skin, and at the same time need to retain effective ingredients to improve the texture of the skin. Therefore, combining ointments with essential oils as the active ingredients of traditional Chinese medicine in gel compositions, There are special benefits to making the most of it.
  • the essence refers to an oil-water mixture collected by a steam distillation condenser, and the temperature range thereof may be 70-100 ° C; and the pressure range may be -0.01 to 0.01 MPa.
  • the ointment was purified and collected by filtration through a macroporous resin.
  • the macroporous resin can be polar or non-polar.
  • LSA-7 can also use other conventional macroporous resins with a styrene skeleton, such as LSA-33, D101, LS-300, and the like.
  • the washing of the macroporous resin removes organic acids, salts, and macromolecular impurities in the raw materials of traditional Chinese medicine, thereby enhancing gel stability and the ability to contain active ingredients therein.
  • ingredients of all the compositions of the present invention are food additive grade.
  • polymer hydrogel described herein is selected from carbomer, hypromellose, hydroxyethyl cellulose, xanthan gum, and the like.
  • a "polymeric hydrogel” as used herein refers to a hydrogel polymer having a molecular weight greater than 10,000. Those skilled in the art will understand that other types of hydrogels with similar properties can also be used.
  • the surfactants described herein are conventional surfactants used in the field of cosmetics, such as Tween, sodium lauryl sulfate, lecithin, and the like.
  • the content of surfactant is between 0.1-1%, so that as little surfactant as possible can form drug-containing micelles.
  • Additional cosmetically acceptable additives such as humectants, fragrances, colorants, preservatives, and the like can be added to the gel compositions described herein.
  • the gel composition described herein can be made into a facial mask, but also can be made into a cream, lotion, body product, and the like.
  • the product can be made into various forms of facial mask components, such as paper facial masks, directly applied facial masks, disposable facial masks, and the like.
  • the mask of the present invention has the following characteristics:
  • the mask is transparent and moisturized, has a good feel and good appearance, can be enjoyed by users, and is easy to use, avoiding the rough sense of the traditional Chinese medicine mask.
  • the formula is simple and scientific. It makes full use of the effects of traditional Chinese medicine ingredients.
  • the essential oil penetrates and nourishes, and the water-soluble essence is locally recuperated. No artificially synthesized effective ingredients such as hormones and vitamins are added.
  • no bacterial nutritional ingredients are added, and the traditional Chinese medicine ingredients have natural antibacterial properties, no bacteriostatic and preservatives are added to the formula.
  • Example 1 Formulation of a gel composition:
  • Glycerin (Malaysian Coconut Brand, Food Grade)
  • Macroporous resins LSA-7, LSA-33, XDA-1 (Xi'an Lanxiao Technology New Materials Co., Ltd., food grade)
  • Hydroxyethyl cellulose (Shenzhen Shenghai Biological Engineering Co., Ltd., food grade)
  • Hypromellose (Shenzhen Shenghai Biological Engineering Co., Ltd., food grade)
  • the content of traditional Chinese medicine accounts for 32% by weight of the gel, that is, 3.2g of wild chrysanthemum ingredients are contained per 10g of the gel, and the essence accounts for 94% of the weight of the gel.
  • the content of traditional Chinese medicine accounts for 96% by weight of the gel, that is, 9.6g per 10g of the gel contains the rose component, and the essence accounts for 96% by weight of the gel.
  • the content of traditional Chinese medicine accounts for 64% by weight of the gel, that is, 6.4g of paeony is contained per 10g of the gel, and the essence accounts for 92% of the weight of the gel.
  • the hair removal treatment was performed on the administration area 24 hours before the test, one on each side, and the hair removal range was 3cm ⁇ 3cm.
  • the damaged skin group was marked with a "well” with a sterile syringe needle at the medication site, with the degree of bleeding as the degree.
  • the mask is applied to the skin for 14 consecutive days, and the volume is 0.5 g / piece. Carefully observe whether there is erythema and edema at the application site and 1 h after each application, and score it. Observe it continuously for 3 days after the last application .
  • the test results found that the gel compositions of the three examples were all non-irritating.
  • the guinea pigs were randomly divided into 5 groups.
  • the auxiliary control group was given a blank preparation, the test group was given a mask, and the positive control group was given 2-mercaptobenzothiazole.
  • Each group had 10 animals.
  • the skin and hair on both sides of the back of the guinea pig are shaved 24 hours before the administration.
  • the area of the hair removal area is about 3cm ⁇ 3cm.
  • the test article or reference substance is evenly applied to the left hair removal site.
  • the test article is then removed with water; when the test phase is administered, the test article or reference substance is evenly applied to the right shaving site, and it is fixed by a suitable method.
  • test article After 6 hours of application, the test article is removed with water. Animals in each group were sensitized and administered 3 times, with administration every 7 days or so. Dosed once during the challenge phase.
  • the method of administration is skin application, and the dosage is 0.2 g / animal.
  • skin erythema, edema and other abnormal reactions are observed at 1h and 24h after sensitization and at 24h and 48h after challenge. Erythema and edema are scored according to the corresponding standards, and the sensitization effect of the test substance and blank is judged according to the scoring standards.
  • the test results showed that all the gel compositions of the three examples showed no allergies.
  • Guinea pig skin allergy test erythema integral value and incidence of allergic reactions
  • the gel composition prepared by the method and composition of the present invention has a high load of active ingredients of traditional Chinese medicine, is safe and hygienic, and has a good user experience.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une composition de gel comprenant 30 à 95 % en poids d'un extrait de médecine chinoise traditionnelle. L'extrait de médecine chinoise traditionnelle est constitué d'un hydrosol liquide d'extrait de décoction de médecine chinoise traditionnelle et d'une pâte claire obtenue par purification d'un extrait liquide à travers une résine d'adsorption macroporeuse, 0,1 à 1 % en poids d'un tensioactif, 0,5 à 3 % en poids d'un hydrogel polymère, sur la base du poids de la composition de gel. L'invention concerne également un procédé de préparation de la composition et son utilisation dans la préparation de produits cosmétiques.
PCT/CN2019/078711 2018-06-08 2019-03-19 Composition de gel de médecine chinoise traditionnelle, son procédé de préparation et son utilisation WO2019233158A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021517885A JP7440931B2 (ja) 2018-06-08 2019-03-19 漢方薬ゲル組成物及びその調製方法と用途

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CN201810588243.X 2018-06-08
CN201810588243.XA CN108743465A (zh) 2018-06-08 2018-06-08 中药凝胶组合物及其制备方法和用途

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WO2019233158A1 true WO2019233158A1 (fr) 2019-12-12

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108743465A (zh) * 2018-06-08 2018-11-06 苏州思源天然产物研发有限公司 中药凝胶组合物及其制备方法和用途

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JP7440931B2 (ja) 2024-02-29
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