WO2023134783A3 - 一种铝纳米晶递送系统及其结合疫苗抗原分子自组装颗粒佐剂疫苗 - Google Patents

一种铝纳米晶递送系统及其结合疫苗抗原分子自组装颗粒佐剂疫苗 Download PDF

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WO2023134783A3
WO2023134783A3 PCT/CN2023/080897 CN2023080897W WO2023134783A3 WO 2023134783 A3 WO2023134783 A3 WO 2023134783A3 CN 2023080897 W CN2023080897 W CN 2023080897W WO 2023134783 A3 WO2023134783 A3 WO 2023134783A3
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delivery system
nanocrystal
aluminum
self
vaccine
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WO2023134783A2 (zh
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王亚玲
陈春英
赵宇亮
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广东粤港澳大湾区国家纳米科技创新研究院
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Publication of WO2023134783A2 publication Critical patent/WO2023134783A2/zh
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response

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Abstract

本发明涉及生物医药技术与疫苗技术领域，尤其涉及一种表面覆盖Fc亲和蛋白的铝纳米晶递送系统及自组装颗粒佐剂疫苗的制备方法，其中铝纳米晶作为载体，在铝纳米晶表面覆盖有Fc亲和蛋白分子层与抗原分子，由重组Fc Tag的抗原通过与Fc亲和蛋白特异性结合，实现抗原自组装，形成类病毒颗粒疫苗，提升抗原密度，该疫苗能够通过诱导体液及细胞免疫，产生高滴度的特异性抗体。
PCT/CN2023/080897 2022-01-12 2023-03-10 一种铝纳米晶递送系统及其结合疫苗抗原分子自组装颗粒佐剂疫苗 WO2023134783A2 (zh)

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CN202210032960.0 2022-01-12
CN202210032960.0A CN114366809A (zh) 2022-01-12 2022-01-12 一种铝纳米晶递送系统及其结合疫苗抗原分子自组装颗粒佐剂疫苗

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CN114366809A (zh) * 2022-01-12 2022-04-19 广东粤港澳大湾区国家纳米科技创新研究院 一种铝纳米晶递送系统及其结合疫苗抗原分子自组装颗粒佐剂疫苗

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