WO2022133626A1 - 一种快速成膜液体创可贴及其制备方法 - Google Patents

一种快速成膜液体创可贴及其制备方法 Download PDF

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WO2022133626A1
WO2022133626A1 PCT/CN2020/137854 CN2020137854W WO2022133626A1 WO 2022133626 A1 WO2022133626 A1 WO 2022133626A1 CN 2020137854 W CN2020137854 W CN 2020137854W WO 2022133626 A1 WO2022133626 A1 WO 2022133626A1
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parts
film
aid
solution
container
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PCT/CN2020/137854
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English (en)
French (fr)
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吴克
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江苏奇力康皮肤药业有限公司
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Priority to PCT/CN2020/137854 priority Critical patent/WO2022133626A1/zh
Publication of WO2022133626A1 publication Critical patent/WO2022133626A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form

Definitions

  • the invention belongs to the technical field of medical devices, and particularly relates to a rapid film-forming liquid band-aid and a preparation method thereof.
  • the film-forming materials and solvent reagents used in production are also different.
  • the water-insoluble polymer as the film-forming material has good flexibility and elasticity.
  • the Band-Aid In order to shorten the film-forming time, the Band-Aid generally uses a volatile organic solvent with a large amount of alcohol added. Therefore, a strong tingling sensation will occur during use. ;
  • the liquid Band-Aid with water-soluble polymer as the film-forming material has excellent water absorption and swelling property, the film is brittle and cannot add a large amount of volatile organic solvent to shorten the film-forming time, resulting in a long film-forming time.
  • the main purpose of the present invention is to provide a rapid film-forming liquid Band-Aid and a preparation method thereof, using polyacrylic acid resin, polyvinyl butyral and water-soluble carboxymethyl shell Polysaccharide and polyvinyl alcohol are used as a joint film-forming agent to shorten the film-forming time on the premise of ensuring that the liquid Band-Aid has both flexibility and water-swelling properties.
  • the present invention provides the following technical solutions:
  • a rapid film-forming liquid Band-Aid comprising the following components by weight:
  • the plasticizer is di-n-octyl phthalate.
  • porogen is polyvinylpyrrolidone-vinyl acetate copolymer.
  • Another object of the present invention is to provide a preparation method of the fast film-forming liquid Band-Aid, comprising the following steps:
  • the present invention adopts polyacrylic acid resin, polyvinyl butyral, water-soluble carboxymethyl chitosan and polyvinyl alcohol as joint film-forming agents, so as to shorten the shortening time under the premise of ensuring that the liquid band-aid has both flexibility and water absorption and swelling properties. film forming time;
  • Polyacrylic resin, polyvinyl butyral and polyvinyl alcohol are all film-forming materials with good flexibility and elasticity. Their synergistic effect makes the film formed by liquid Band-Aid good flexibility and elasticity, and has good tensile strength. ;
  • the water-soluble carboxymethyl chitosan and polyvinyl alcohol make the liquid Band-Aid have water absorption and swelling properties, so that the liquid Band-Aid can be kept dry after being filmed;
  • the film-forming time is shortened by the synergistic effect of hydrogen peroxide, Panax notoginseng extract and Arborvitae leaf extract;
  • the polyvinylpyrrolidone-vinyl acetate copolymer is used to form through-holes in the composite film and has excellent air permeability, and is a good porogen.
  • a rapid film-forming liquid Band-Aid comprising the following components by weight:
  • the preparation method of the fast film-forming liquid Band-Aid comprises the following steps:
  • Polyacrylic resin is a white strip or powder, which is easy to agglomerate in ethanol. This product is dissolved in warm ethanol. With polyacrylic resin as the main component, it will volatilize immediately when applied to the wound, forming a very soft, viscous, breathable, tough, elastic and thin translucent film, so it has antibacterial properties on the wound and can It plays the role of preventing wound pollution and protection, and has the characteristics of waterproof, easy to use, and can provide the best moist environment required for wound healing, even for sensitive skin. It has the functions of preventing wound infection, protecting and waterproofing. It can be used for abrasions, protection of sutures after surgery, skin allergies, barb scratches, cracks, chapped, small knife marks, mosquito bite prevention, quick removal of blood scabs, scars, mosquito spots, etc.
  • PVB is the English abbreviation of polyvinyl butyral. It is the general term for the condensation products of polyvinyl alcohol and various aldehydes. It is a thermoplastic resin, insoluble in water, soluble in various alcohols, ethers, ketones, esters and Other organic solvents, e.g.
  • Polyvinyl alcohol the appearance is white flake, flocculent or powdery solid, odorless. Soluble in water (above 95°C), slightly soluble in dimethyl sulfoxide, insoluble in gasoline, kerosene, vegetable oil, benzene, toluene, dichloroethane, carbon tetrachloride, acetone, ethyl acetate, methanol, ethylene dichloride Alcohol etc.
  • polyvinyl alcohol is a very safe macromolecular organic compound, non-toxic to the human body, no side effects, and has good biocompatibility, especially in medical applications such as its water-based gel in ophthalmology, wound dressings and artificial joints It is widely used, and polyvinyl alcohol is also used in medicinal films. Its safety can be seen in products used for wound skin repair and eye drops. Some of these models are also often used in facial masks, facial cleansers, lotions and lotions in cosmetics, and are a commonly used safety film-forming agent. As the main material for film formation, it can quickly form a film when applied on the skin surface. The film has good toughness, is not easy to be brittle, maintains a long time, and has good air permeability and water resistance, which can avoid frequent application.
  • Polyvinyl alcohol is soluble in water and generally needs to be heated to about 95°C in order to dissolve completely.
  • the material should be added to room temperature water under stirring. After uniform dispersion, the temperature is increased to accelerate the dissolution, which can prevent agglomeration and affect the dissolution speed.
  • a very strong and tear-resistant film can be formed after the solvent is volatilized, and the wear resistance is also good. The mechanical properties of the film can be adjusted by the amount of plasticizer and water content.
  • Polyvinyl alcohol is hygroscopic, and the film of polyvinyl alcohol can remain dry after the solvent evaporates.
  • Chitosan has good film-forming properties and is a commonly used biofilm-forming material. It also has the functions of bacteriostatic, hemostasis, healing, and analgesia. It can promote the division and cell division of epithelial cells, fibroblasts and other cells. The growth of extracellular matrix significantly accelerates wound healing and reduces scarring.
  • Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial properties, preservation of freshness, an amphoteric polyelectrolyte, etc. It has many applications in cosmetics, medicine, etc. One of the most studied chitosan derivatives in recent years, its stable properties, antibacterial and anti-infection, are of great significance in medicine and health care products.
  • Diacetone alcohol is a medium boiling point solvent with low viscosity and little influence by temperature. It can dissolve resin, nitrocellulose, cellulose acetate, ethyl cellulose, plexiglass, polystyrene and polyvinyl acetate. Diacetone alcohol, also known as diacetone alcohol, methyl pentanol, 2-methyl-4-oxopentanol, or DAA for short, is a colorless liquid with a slight mint smell. It is miscible with water, alcohols, ethers, aromatic hydrocarbons and halogenated hydrocarbons, but not with higher aliphatic hydrocarbons.
  • Isopropanol is an organic compound, the molecular formula is C3H8O, is the isomer of n-propanol, alias dimethyl methanol, 2-propanol, also known as IPA in the industry. It is a colorless and transparent liquid, flammable, and has an odor like a mixture of ethanol and acetone. Soluble in water, also soluble in most organic solvents such as alcohol, ether, benzene, chloroform, etc. Isopropyl alcohol is an important chemical product and raw material, mainly used in pharmaceuticals, cosmetics, fragrances, coatings, etc.
  • Volatile isopropanol, ethanol, diacetone alcohol, and ethyl acetate are used as a solvent combination to reduce the ethanol content and reduce the amount of ethanol as much as possible to reduce the irritation to the wound surface during use.
  • catalase an enzyme that catalyzes the breakdown of hydrogen peroxide into oxygen and water.
  • the self-disproportionation reaction of hydrogen peroxide is an exothermic reaction.
  • the generation of reaction heat is accelerated, the local temperature rises, the volatilization of the solvent is accelerated, and the film-forming and curing speed is accelerated, further shortening the membrane time.
  • Panax notoginseng extract can significantly improve the film-forming properties, greatly shorten the film-forming time, and also greatly shorten the plasma recalcification time; the oriental orientalis leaf extract can effectively shorten the plasma recalcification time and promote wound hemostasis.
  • the liquid Band-Aid has a short film-forming time, can dry quickly and form a breathable and waterproof elastic protective film, which instantly seals the wound surface, prevents wound infection and bacterial invasion, and promotes wound healing.
  • Di-n-octyl phthalate is a conventional plasticizer.
  • Polyvinylpyrrolidone-vinyl acetate copolymer is also an alcohol-soluble and ideal film-forming material, with good non-toxic and tasteless, no irritation to the skin, no pollution, close contact with the skin, easy to degrade naturally and other excellent properties. nature.
  • Polyvinylpyrrolidone-vinyl acetate copolymer is completely soluble in water, also soluble in ethanol, isopropanol, propylene glycol, glycerol, low molecular weight polyethylene glycol and other solvents as well as ester and ketone solvents, slightly soluble in ether and Hydrocarbon solvents.
  • Polyvinylpyrrolidone-vinyl acetate copolymer is a highly cross-linked polymer material with a three-dimensional network structure, which can be used as a porogen.
  • a rapid film-forming liquid Band-Aid comprising the following components by weight:
  • the preparation method of the rapid film-forming liquid Band-Aid is as in Example 1.
  • a rapid film-forming liquid Band-Aid comprising the following components by weight:
  • the preparation method of the rapid film-forming liquid Band-Aid is as in Example 1.
  • Example 3 The difference between this comparative example and Example 3 is that it does not contain polyacrylic resin and polyvinyl butyral.
  • the plan is as follows:
  • a rapid film-forming liquid Band-Aid comprising the following components by weight: 15 parts of polyvinyl alcohol, 30 parts of carboxymethyl chitosan, 4 parts of di-n-octyl phthalate, and polyvinylpyrrolidone-vinyl acetate copolymerization 3 parts of ethanol, 35 parts of isopropanol, 30 parts of diacetone alcohol, 40 parts of ethyl acetate, 20 parts of hydrogen peroxide, 5 parts of Panax notoginseng extract, 5 parts of arborvitae leaf extract, and 40 parts of distilled water.
  • the preparation method of the fast film-forming liquid Band-Aid comprises the following steps:
  • This comparative example is different from Example 3 in that it does not contain hydrogen peroxide, Panax notoginseng extract and Arborvitae leaf extract.
  • the plan is as follows:
  • a rapid film-forming liquid Band-Aid comprising the following components by weight: 15 parts of polyacrylic resin, 25 parts of polyvinyl butyral, 15 parts of polyvinyl alcohol, 30 parts of carboxymethyl chitosan, phthalic acid 4 parts of di-n-octyl ester, 3 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 40 parts of ethanol, 35 parts of isopropanol, 30 parts of diacetone alcohol, 40 parts of ethyl acetate, and 40 parts of distilled water.
  • the preparation method of the fast film-forming liquid Band-Aid comprises the following steps:
  • Example 3 The difference between this comparative example and Example 3 is that it does not contain hydrogen peroxide.
  • the plan is as follows:
  • a rapid film-forming liquid Band-Aid comprising the following components by weight: 15 parts of polyacrylic resin, 25 parts of polyvinyl butyral, 15 parts of polyvinyl alcohol, 30 parts of carboxymethyl chitosan, phthalic acid 4 parts of di-n-octyl ester, 3 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 40 parts of ethanol, 35 parts of isopropanol, 30 parts of diacetone alcohol, 40 parts of ethyl acetate, 5 parts of Panax notoginseng extract, arborvitae 5 parts of leaf extract, 40 parts of distilled water.
  • the preparation method of the fast film-forming liquid Band-Aid comprises the following steps:
  • Example 3 The difference between this comparative example and Example 3 is that it does not contain Panax notoginseng extract and oriental orientalis leaf extract.
  • the plan is as follows:
  • a rapid film-forming liquid Band-Aid comprising the following components by weight: 15 parts of polyacrylic resin, 25 parts of polyvinyl butyral, 15 parts of polyvinyl alcohol, 30 parts of carboxymethyl chitosan, phthalic acid 4 parts of di-n-octyl ester, 3 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 40 parts of ethanol, 35 parts of isopropanol, 30 parts of diacetone alcohol, 40 parts of ethyl acetate, 20 parts of hydrogen peroxide and 40 parts of distilled water.
  • the preparation method of the fast film-forming liquid Band-Aid comprises the following steps:
  • the sterility is checked according to the sterility inspection method of the second appendix XIH of the 2010 edition of the Chinese Pharmacopoeia, and the tensile strength of the film is checked according to the GB13022-91 plastic film tensile property test method Test; the method for testing the film formation time is as follows: apply the sample to a glass plate, coat with a glass rod, use a stopwatch to time the time, and stop the time when the film can be lifted. The results are shown in Table 1.
  • Example 1-3 adopts polyacrylic acid resin, polyvinyl butyral and water-soluble carboxymethyl chitosan and polyvinyl alcohol as joint film-forming agents, Polyacrylic resin, polyvinyl butyral and polyvinyl alcohol are all film-forming materials with good flexibility and elasticity. Their synergistic effect makes the film formed by liquid Band-Aid good flexibility and elasticity, and has good tensile strength.
  • the film-forming time is shortened by the synergistic effect of hydrogen peroxide, Panax notoginseng extract and Arborvitae leaf extract, that is, the film-forming time can be shortened on the premise of ensuring that the liquid Band-Aid has both flexibility and water absorption and swelling.
  • the members of the test group generally have a relatively fast film-forming time, and the film-forming time of the two control groups is similar. relatively slow.
  • the present invention adopts polyacrylic acid resin, polyvinyl butyral, water-soluble carboxymethyl chitosan and polyvinyl alcohol as joint film-forming agents, and shortens the time while ensuring that the liquid Band-Aid has both flexibility and water-swelling property. film formation time.

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Abstract

一种快速成膜液体创可贴，包括如下重量份的组分：聚丙烯酸树脂10-15份，聚乙烯醇缩丁醛10-25份，聚乙烯醇7-15份，羧甲基壳聚糖15-30份，增塑剂1-4份，致孔剂1-3份，乙醇30-40份、异丙醇25-35份，二丙酮醇20-30份、乙酸乙酯25-40份，双氧水6-20份，三七提取液2-5份，侧柏叶提取液2-5份，蒸馏水25-40份；其采用聚丙烯酸树脂、聚乙烯醇缩丁醛及水溶性的羧甲基壳聚糖和聚乙烯醇作为联合成膜剂，在确保液体创可贴兼具柔韧性和吸水溶胀性的同时缩短了成膜时间。

Description

一种快速成膜液体创可贴及其制备方法 技术领域
本发明属于医疗器械技术领域，具体涉及一种快速成膜液体创可贴及其制备方法。
背景技术
传统创可贴借助胶布包扎创口部位，有些创口用传统创可贴不方便包扎，比长条形伤口不好全面覆盖创口，关节处的伤口创面的包扎容易变形脱落，且需要反复多次更换易造成伤口的二次伤害，同时包裹后透气性差。鉴于传统创可贴的不足，目前液体创可贴的研究和应用越来越广泛。液体创可贴使用时将液体涂抹或喷洒于伤口，待溶剂挥发后，伤口表面形成一个透气、防水的隐形高分子薄膜，用后不需撕脱且覆盖面积可大可小。但是发明人发现现有创可贴具有以下缺陷：
目前液体创可贴产品很多，生产用的成膜材料和溶媒试剂也不尽相同。目前以非水溶性高分子聚合物为成膜材料的液体柔韧性和弹性好，创可贴为缩短成膜时间一般采用加入大量酒精为主的易挥发的有机溶剂，因此使用时会出现强烈刺痛感；以水溶性高分子聚合物为成膜材料的液体创可贴虽有优良吸水溶胀性，膜薄脆且不能加入大量容易挥发的有机成分溶剂而缩短成膜时间，导致成膜时间长。
鉴于现有技术中存在的不足之处，有必要提供一种快速成膜液体创可贴及其制备方法，以在确保液体创可贴功效的前提下缩短成膜时间。
发明内容
针对现有技术中存在的不足之处，本发明的主要目的是，提供一种快速成膜液体创可贴及其制备方法，采用聚丙烯酸树脂、聚乙烯醇缩丁醛及水溶 性的羧甲基壳聚糖和聚乙烯醇作为联合成膜剂，以在确保液体创可贴兼具柔韧性和吸水溶胀性的前提下缩短成膜时间。
为了实现本发明的上述目的，本发明提供如下技术方案：
一种快速成膜液体创可贴，包括如下重量份的组分：
聚丙烯酸树脂10-15份，聚乙烯醇缩丁醛10-25份，聚乙烯醇7-15份，羧甲基壳聚糖15-30份，增塑剂1-4份，致孔剂1-3份，乙醇30-40份、异丙醇25-35份，二丙酮醇20-30份、乙酸乙酯25-40份，双氧水6-20份，三七提取液2-5份，侧柏叶提取液2-5份，蒸馏水25-40份；其中，聚丙烯酸树脂、聚乙烯醇缩丁醛及水溶性的羧甲基壳聚糖和聚乙烯醇作为联合成膜剂，以使得液体创可贴兼具柔韧性和吸水溶胀性；采用乙醇、异丙醇，二丙酮醇、乙酸乙酯作为联合溶剂减轻刺激，所述双氧水、三七提取液和侧柏叶提取液协同作用缩短成膜时间。
进一步地，所述增塑剂为邻苯二甲酸二正辛酯。
进一步地，所述致孔剂为聚乙烯吡咯烷酮-醋酸乙烯酯共聚物。
本发明的另一个目的在于提供所述快速成膜液体创可贴的制备方法，包括以下步骤：
1)将配方量的50％-60％的乙醇置于第一容器中，然后称取配方量的聚丙烯酸树脂加入第一容器中,微温使聚丙烯酸树脂溶解，放冷得到第一溶液；
2)将配方量的35％-50％的蒸馏水加入第二容器中，然后将配方量的聚乙烯醇在搅拌下加入第二容器中，待分散均匀后升温至95℃左右加速聚乙烯醇溶解，放冷得到第二溶液；
3)称取配方量的异丙醇、二丙酮醇、乙酸乙酯及余量乙醇置于第三容器中混合均匀，加入配方量的增塑剂及配方量的聚乙烯醇缩丁醛密闭搅拌至溶解得到第三溶液；
4)将余量蒸馏水置于第四容器中，称取配方量的致孔剂及配方量的羧甲基壳聚糖于第四容器中搅拌至溶解得到第四溶液；
5)所述第一溶液、第二溶液、第三溶液和第四溶液混合后搅拌均匀，然后加入配方量的双氧水、三七提取液和侧柏叶提取液混合后搅拌均匀得到快速成膜液体创可贴。
上述技术方案中的一个技术方案具有如下优点或有益效果：
本发明采用聚丙烯酸树脂、聚乙烯醇缩丁醛及水溶性的羧甲基壳聚糖和聚乙烯醇作为联合成膜剂，以在确保液体创可贴兼具柔韧性和吸水溶胀性的前提下缩短成膜时间；
聚丙烯酸树脂、聚乙烯醇缩丁醛和聚乙烯醇均为柔韧性好且富有弹性的成膜材料，其协同作用使得液体创可贴所成膜柔韧性好且富有弹性，有较好的拉伸强度；
水溶性的羧甲基壳聚糖、聚乙烯醇使得液体创可贴具有吸水溶涨性，以使得所述液体创可贴成膜后保持干燥；
采用挥发性的乙醇、异丙醇，二丙酮醇、乙酸乙酯作为联合溶剂组合，加速了溶剂的挥发，缩短成膜时间，且降低了乙醇含量，减轻将液体创可贴施用于皮肤时对创口造成的疼痛刺激；
通过双氧水、三七提取液和侧柏叶提取液协同作用缩短成膜时间；
聚乙烯吡咯烷酮-醋酸乙烯酯共聚物用于在复合膜中形成通孔起到优良的透气作用，是良好的致孔剂。
具体实施方式
应当理解，本文所使用的诸如“具有”、“包含”以及“包括”术语并不配出一个或多个其它组合的存在或添加。
实施例1
一种快速成膜液体创可贴，包括如下重量份的组分：
聚丙烯酸树脂10份，聚乙烯醇缩丁醛10份，聚乙烯醇7份，羧甲基壳聚糖15份，邻苯二甲酸二正辛酯1份，聚乙烯吡咯烷酮-醋酸乙烯酯共聚物1 份，乙醇30份、异丙醇25份，二丙酮醇20份、乙酸乙酯25份，双氧水6份，三七提取液2份，侧柏叶提取液2份，蒸馏水25份。
所述快速成膜液体创可贴的制备方法，包括以下步骤：
1)将配方量的50％-60％的乙醇置于第一容器中，然后称取配方量的聚丙烯酸树脂加入第一容器中,微温使聚丙烯酸树脂溶解，放冷得到第一溶液；
2)将配方量的35％-50％的蒸馏水加入第二容器中，然后将配方量的聚乙烯醇在搅拌下加入第二容器中，待分散均匀后升温至95℃左右加速聚乙烯醇溶解，放冷得到第二溶液；
3)称取配方量的异丙醇、二丙酮醇、乙酸乙酯及余量乙醇置于第三容器中混合均匀，加入配方量的邻苯二甲酸二正辛酯及配方量的聚乙烯醇缩丁醛密闭搅拌至溶解得到第三溶液；
4)将余量蒸馏水置于第四容器中，称取配方量的聚乙烯吡咯烷酮-醋酸乙烯酯共聚物及配方量的羧甲基壳聚糖于第四容器中搅拌至溶解得到第四溶液；
5)所述第一溶液、第二溶液、第三溶液和第四溶液混合后搅拌均匀，然后加入配方量的双氧水、三七提取液和侧柏叶提取液混合后搅拌均匀得到快速成膜液体创可贴。
聚丙烯酸树脂为白色条状物或粉末，在乙醇中易结块。本品在温乙醇中溶解。以聚丙烯酸树脂为主要成分，涂抹于伤口会立即挥发，形成非常柔软、有粘性、透气性好、韧性好、富有弹性、很薄的半透明胶膜，因此对创面伤口有阻菌性，能够起到防止伤口污染和保护的作用且具有防水的特点，使用方便，能提供伤口愈合所需要的最好的湿润环境即使是敏感性皮肤也能使用。具有防止伤口感染、保护及防水的功能。可以用于擦伤、外科手术后缝合部位的保护、皮肤过敏、倒刺刮伤、裂痕、皲裂、细小的刀痕、防蚊虫叮咬、快速去除血痂、伤疤、蚊斑等。
PVB是聚乙烯醇缩丁醛polyvinyl butyral的英文缩写，是聚乙烯醇与各种 醛类的缩合产物的统称，为热塑性树脂，不溶于水，可溶于各种醇、醚、酮、酯和其他有机溶剂，比如其溶于甲醇，正丙醇，异丙醇，正戊醇，苯甲醇，丁醇、双丙酮醇，丙二醇乙醚/甲醚/丙醚，丙酮、甲乙酮、环已酮、二氯甲烷、氯仿、乙酸甲酯、乙酸乙酯、乙酸丁酯，乙酸等，是一种醇溶性的较为理想的成膜材料，具有优良的柔软性和挠曲性和弹性，无毒无味对皮肤无刺激，形成的膜韧性强且弹性好。
聚乙烯醇，外观是白色片状、絮状或粉末状固体，无味。溶于水(95℃以上)，微溶于二甲基亚砜，不溶于汽油、煤油、植物油、苯、甲苯、二氯乙烷、四氯化碳、丙酮、醋酸乙酯、甲醇、乙二醇等。医药级聚乙烯醇，是一种极安全的高分子有机物，对人体无毒，无副作用，具有良好的生物相容性，尤其在医疗中的如其水性凝胶在眼科、伤口敷料和人工关节方面的有广泛应用，同时聚乙烯醇在药用膜等方面也有使用。其安全性可以从用于伤口皮肤修复和眼部滴眼液产品可见一斑。其中一些型号也常被用在化妆品中的面膜、洁面膏、化妆水及乳液中，是一种常用的安全性成膜剂。作为成膜的主要材料，施用在皮肤表面能快速成膜，膜的韧性好，不易脆，维持时间长，有良好的透气性和防水性，可以避免频繁施药。
聚乙烯醇溶于水，为了完全溶解一般需加热到95℃左右。溶解聚乙烯醇应先将物料在搅拌下加入室温水中.分散均匀后再升温加速溶解，这样可以防止结块，影响溶解速度。聚乙烯醇溶于水后，待溶剂挥发后可以形成非常强韧耐撕裂的膜，耐磨性也好，膜的力学性能可以通过增塑剂用量及含水量调节。聚乙烯醇具有吸湿性，聚乙烯醇的膜在溶剂挥发后仍可以保持干燥。
壳聚糖类物质具良好的成膜性，是常用的生物成膜材料，同时具有抑菌、止血、促愈、镇痛的功能，能促进上皮细胞、成纤维细胞等多种细胞分裂和胞外基质生长，明显加速创面的愈合、并减少疤痕形成。羧甲基壳聚糖是一种水溶性壳聚糖衍生物，有许多特性，如抗菌性强，具有保鲜作用，是一种两性聚电解质等，在化妆品、医药等方面有多种应用，也是近年来研究得较 多的壳聚糖衍生物之一，其性质稳定，抗菌抗感染，在医药、保健品方面等都有重要的意义。
二丙酮醇是中沸点溶剂，粘度低，受温度的影响小，能溶解树脂、硝酸纤维素、醋酸纤维素、乙基纤维素、有机玻璃、聚苯乙烯、聚醋酸乙烯酯。二丙酮醇，又称双丙酮醇、甲基戊酮醇、2-甲-4-氧代戊醇，简称DAA，是无色液体，稍有薄荷气味。能与水、醇、醚、芳烃和卤代烃混溶，但不与高级脂肪烃混溶。
异丙醇是一种有机化合物，分子式是C3H8O，是正丙醇的同分异构体，别名二甲基甲醇、2-丙醇，行业中也作IPA。是无色透明液体，易燃，有似乙醇和丙酮混合物的气味。溶于水，也溶于醇、醚、苯、氯仿等多数有机溶剂。异丙醇是重要的化工产品和原料，主要用于制药、化妆品、香料、涂料等。
采用挥发性的异丙醇、乙醇、二丙酮醇、乙酸乙酯作为溶剂组合，降低乙醇含量，尽可能减少乙醇用量以减小使用过程中对创伤面的刺激。
人体组织中有过氧化氢酶，其是催化过氧化氢分解成氧和水的酶。双氧水的自身歧化反应是放热反应，在遇到皮肤创伤表面过氧化氢酶的作用下，加速其反应热的产生，局部升温，加速挥发溶剂，达到加快成膜固化速度的作用，进一步缩短成膜时间。
三七提取液加入到液体创可贴配方中可以显著提高成膜性，大幅缩短成膜时间，同时血浆复钙时间也大大缩短；侧柏叶提取液能有效缩短血浆复钙时间，促进伤口止血，所得液体创可贴成膜时间短，可快速干燥并形成透气防水的弹性保护膜，将创伤面瞬间封闭，防止伤口感染和细菌的侵入，促进伤口的愈合。
邻苯二甲酸二正辛酯为常规增塑剂。聚乙烯吡咯烷酮-醋酸乙烯酯共聚物也是一种醇溶性的非常理想的成膜材料，具有很好的无毒无味，对皮肤没有刺激、不被污染、与皮肤接触紧密、容易自然降解等优秀的性质。聚乙烯吡咯烷酮-醋酸乙烯酯共聚物完全溶于水，也溶于乙醇、异丙醇、丙二醇、甘油、 低分子量聚乙二醇等类溶剂及酯类、酮类溶剂中，微溶于乙醚及烃类溶剂。聚乙烯吡咯烷酮-醋酸乙烯酯共聚物为具有立体网状结构的高度交联的高分子材料，可作为致孔剂。
实施例2
一种快速成膜液体创可贴，包括如下重量份的组分：
聚丙烯酸树脂12份，聚乙烯醇缩丁醛20份，聚乙烯醇10份，羧甲基壳聚糖20份，邻苯二甲酸二正辛酯2份，聚乙烯吡咯烷酮-醋酸乙烯酯共聚物2份，乙醇35份、异丙醇30份，二丙酮醇25份、乙酸乙酯35份，双氧水15份，三七提取液3份，侧柏叶提取液4份，蒸馏水35份。
所述快速成膜液体创可贴的制备方法如实施例1。
实施例3
一种快速成膜液体创可贴，包括如下重量份的组分：
聚丙烯酸树脂15份，聚乙烯醇缩丁醛25份，聚乙烯醇15份，羧甲基壳聚糖30份，邻苯二甲酸二正辛酯4份，聚乙烯吡咯烷酮-醋酸乙烯酯共聚物3份，乙醇40份、异丙醇35份，二丙酮醇30份、乙酸乙酯40份，双氧水20份，三七提取液5份，侧柏叶提取液5份，蒸馏水40份。
所述快速成膜液体创可贴的制备方法如实施例1。
对比例1
本对比例与实施例3不同的是，不含聚丙烯酸树脂和聚乙烯醇缩丁醛。方案如下：
一种快速成膜液体创可贴，包括如下重量份的组分：聚乙烯醇15份，羧甲基壳聚糖30份，邻苯二甲酸二正辛酯4份，聚乙烯吡咯烷酮-醋酸乙烯酯共聚物3份，乙醇40份、异丙醇35份，二丙酮醇30份、乙酸乙酯40份，双氧水20份，三七提取液5份，侧柏叶提取液5份，蒸馏水40份。
所述快速成膜液体创可贴的制备方法，包括以下步骤：
1)将配方量的35％-50％的蒸馏水加入第一容器中，然后将配方量的聚 乙烯醇在搅拌下加入第一容器中，待分散均匀后升温至95℃左右加速聚乙烯醇溶解，放冷得到第一溶液；
2)将余量蒸馏水置于第二容器中，称取配方量的聚乙烯吡咯烷酮-醋酸乙烯酯共聚物和配方量的羧甲基壳聚糖于第二容器中搅拌至溶解得到第二溶液；
3)所述第一溶液、第二溶液混合后搅拌均匀，加入配方量的邻苯二甲酸二正辛酯；然后加入配方量的双氧水、三七提取液和侧柏叶提取液混合后搅拌均匀得到快速成膜液体创可贴。
对比例2
本对比例与实施例3不同的是，不含双氧水、三七提取液和侧柏叶提取液。方案如下：
一种快速成膜液体创可贴，包括如下重量份的组分：聚丙烯酸树脂15份，聚乙烯醇缩丁醛25份，聚乙烯醇15份，羧甲基壳聚糖30份，邻苯二甲酸二正辛酯4份，聚乙烯吡咯烷酮-醋酸乙烯酯共聚物3份，乙醇40份、异丙醇35份，二丙酮醇30份、乙酸乙酯40份，蒸馏水40份。
所述快速成膜液体创可贴的制备方法，包括以下步骤：
1)将配方量的50％-60％的乙醇置于第一容器中，然后称取配方量的聚丙烯酸树脂加入第一容器中,微温使聚丙烯酸树脂溶解，放冷得到第一溶液；
2)将配方量的35％-50％的蒸馏水加入第二容器中，然后将配方量的聚乙烯醇在搅拌下加入第二容器中，待分散均匀后升温至95℃左右加速聚乙烯醇溶解，放冷得到第二溶液；
3)称取配方量的异丙醇、二丙酮醇、乙酸乙酯及余量乙醇置于第三容器中混合均匀，加入配方量的邻苯二甲酸二正辛酯及配方量的聚乙烯醇缩丁醛密闭搅拌至溶解得到第三溶液；
4)将余量蒸馏水置于第四容器中，称取配方量的聚乙烯吡咯烷酮-醋酸乙烯酯共聚物及配方量的羧甲基壳聚糖于第四容器中搅拌至溶解得到第四溶 液；
5)所述第一溶液、第二溶液、第三溶液和第四溶液混合后搅拌均匀得到快速成膜液体创可贴。
对比例3
本对比例与实施例3不同的是，不含双氧水。方案如下：
一种快速成膜液体创可贴，包括如下重量份的组分：聚丙烯酸树脂15份，聚乙烯醇缩丁醛25份，聚乙烯醇15份，羧甲基壳聚糖30份，邻苯二甲酸二正辛酯4份，聚乙烯吡咯烷酮-醋酸乙烯酯共聚物3份，乙醇40份、异丙醇35份，二丙酮醇30份、乙酸乙酯40份，三七提取液5份，侧柏叶提取液5份，蒸馏水40份。
所述快速成膜液体创可贴的制备方法，包括以下步骤：
1)将配方量的50％-60％的乙醇置于第一容器中，然后称取配方量的聚丙烯酸树脂加入第一容器中,微温使聚丙烯酸树脂溶解，放冷得到第一溶液；
2)将配方量的35％-50％的蒸馏水加入第二容器中，然后将配方量的聚乙烯醇在搅拌下加入第二容器中，待分散均匀后升温至95℃左右加速聚乙烯醇溶解，放冷得到第二溶液；
3)称取配方量的异丙醇、二丙酮醇、乙酸乙酯及余量乙醇置于第三容器中混合均匀，加入配方量的邻苯二甲酸二正辛酯及配方量的聚乙烯醇缩丁醛密闭搅拌至溶解得到第三溶液；
4)将余量蒸馏水置于第四容器中，称取配方量的聚乙烯吡咯烷酮-醋酸乙烯酯共聚物及配方量的羧甲基壳聚糖于第四容器中搅拌至溶解得到第四溶液；
5)所述第一溶液、第二溶液、第三溶液和第四溶液混合后搅拌均匀，然后加入配方量三七提取液和侧柏叶提取液混合后搅拌均匀得到快速成膜液体创可贴。
对比例4
本对比例与实施例3不同的是，不含三七提取液和侧柏叶提取液。方案如下：
一种快速成膜液体创可贴，包括如下重量份的组分：聚丙烯酸树脂15份，聚乙烯醇缩丁醛25份，聚乙烯醇15份，羧甲基壳聚糖30份，邻苯二甲酸二正辛酯4份，聚乙烯吡咯烷酮-醋酸乙烯酯共聚物3份，乙醇40份、异丙醇35份，二丙酮醇30份、乙酸乙酯40份，双氧水20份，蒸馏水40份。
所述快速成膜液体创可贴的制备方法，包括以下步骤：
1)将配方量的50％-60％的乙醇置于第一容器中，然后称取配方量的聚丙烯酸树脂加入第一容器中,微温使聚丙烯酸树脂溶解，放冷得到第一溶液；
2)将配方量的35％-50％的蒸馏水加入第二容器中，然后将配方量的聚乙烯醇在搅拌下加入第二容器中，待分散均匀后升温至95℃左右加速聚乙烯醇溶解，放冷得到第二溶液；
3)称取配方量的异丙醇、二丙酮醇、乙酸乙酯及余量乙醇置于第三容器中混合均匀，加入配方量的邻苯二甲酸二正辛酯及配方量的聚乙烯醇缩丁醛密闭搅拌至溶解得到第三溶液；
4)将余量蒸馏水置于第四容器中，称取配方量的聚乙烯吡咯烷酮-醋酸乙烯酯共聚物及配方量的羧甲基壳聚糖于第四容器中搅拌至溶解得到第四溶液；
5)所述第一溶液、第二溶液、第三溶液和第四溶液混合后搅拌均匀，然后加入配方量的双氧水混合后搅拌均匀得到快速成膜液体创可贴。
测试例1
将实施例1-3、对比例1-4提供的方案获得的快速成膜液体创可贴各取约3g，流延铺平，自然干燥，制备成薄膜，然后进行效果对比，从无菌效果、膜拉伸强度、成膜时间三方面进行比较，其中，无菌按照《中国药典》2010年版二部附录XIH无菌检查法检查，所述膜拉伸强度按GB13022-91塑料薄膜拉伸性能试验方法测试；所述成膜时间测试方法为，将样品施用于玻璃板 上，采用玻璃棒涂覆，采用秒表计时，当膜能够揭起时停止计时。结果如表1所示。
表1 实施例1-3、对比例1-4提供的快速成膜液体创可贴的性能
  无菌 膜拉伸强度(MPa) 成膜时间(min)
实施例1 符合规定 10 0.5
实施例2 符合规定 11 0.4
实施例3 符合规定 14 0.3
对比例1 符合规定 4 0.35
对比例2 符合规定 13 1.7
对比例3 符合规定 13.5 0.65
对比例4 符合规定 13.1 0.8
由表1可知，相比于对比例1-4，实施例1-3采用聚丙烯酸树脂、聚乙烯醇缩丁醛及水溶性的羧甲基壳聚糖和聚乙烯醇作为联合成膜剂，聚丙烯酸树脂、聚乙烯醇缩丁醛和聚乙烯醇均为柔韧性好且富有弹性的成膜材料，其协同作用使得液体创可贴所成膜柔韧性好且富有弹性，有较好的拉伸强度；通过双氧水、三七提取液和侧柏叶提取液协同作用缩短成膜时间，即使得在确保液体创可贴兼具柔韧性和吸水溶胀性的前提下缩短成膜时间。
测试例2
将200例皮肤损伤的志愿者随机平均分成2组，即试验组和对照组，每组100人，试验组采用实施例3的液体创可贴，对照组采用购买的涂美液体创可贴，观察疗效，从膜拉伸强度、成膜时间、隔离效果和吸水溶胀性进行评价，结果见表2。
表2 试验组和对照组测试结果
组别 膜拉伸强度优良 成膜时间快 隔离效果 吸水溶胀性
试验组 98 99 97 96
对照组 86 70 85 86
从表2可以看出，本实施例3的快速成膜液体创可贴的膜拉伸强度、成膜时间、隔离效果和吸水溶胀性，试验组成员普遍成膜时间比较快，二对照组成膜时间相比而言较慢。
可见，本发明采用聚丙烯酸树脂、聚乙烯醇缩丁醛及水溶性的羧甲基壳聚糖和聚乙烯醇作为联合成膜剂，在确保液体创可贴兼具柔韧性和吸水溶胀性的同时缩短了成膜时间。
尽管本发明的实施方案已公开如上，但其并不仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出与描述的实施方式。

Claims (6)

  1. 一种快速成膜液体创可贴，其特征在于，包括如下重量份的组分：
    聚丙烯酸树脂10-15份，聚乙烯醇缩丁醛10-25份，聚乙烯醇7-15份，羧甲基壳聚糖15-30份，增塑剂1-4份，致孔剂1-3份，乙醇30-40份、异丙醇25-35份，二丙酮醇20-30份、乙酸乙酯25-40份，双氧水6-20份，三七提取液2-5份，侧柏叶提取液2-5份，蒸馏水25-40份；其中，聚丙烯酸树脂、聚乙烯醇缩丁醛及水溶性的羧甲基壳聚糖和聚乙烯醇作为联合成膜剂，以使得液体创可贴兼具柔韧性和吸水溶胀性；采用乙醇、异丙醇，二丙酮醇、乙酸乙酯作为联合溶剂减轻刺激，所述双氧水、三七提取液和侧柏叶提取液协同作用缩短成膜时间。
  2. 如权利要求1所述的快速成膜液体创可贴，其特征在于：所述增塑剂为邻苯二甲酸二正辛酯。
  3. 如权利要求1所述的快速成膜液体创可贴，其特征在于：所述致孔剂为聚乙烯吡咯烷酮-醋酸乙烯酯共聚物。
  4. 一种如权利要求1所述的快速成膜液体创可贴的制备方法，其特征在于，包括以下步骤：
    1)将配方量的50％-60％的乙醇置于第一容器中，然后称取配方量的聚丙烯酸树脂加入第一容器中,微温使聚丙烯酸树脂溶解，放冷得到第一溶液；
    2)将配方量的35％-50％的蒸馏水加入第二容器中，然后将配方量的聚乙烯醇在搅拌下加入第二容器中，待分散均匀后升温至95℃左右加速聚乙烯醇溶解，放冷得到第二溶液；
    3)称取配方量的异丙醇、二丙酮醇、乙酸乙酯及余量乙醇置于第三容器中混合均匀，加入配方量的增塑剂及配方量的聚乙烯醇缩丁醛密闭搅拌至溶解得到第三溶液；
    4)将余量蒸馏水置于第四容器中，称取配方量的致孔剂及配方量的羧甲 基壳聚糖于第四容器中搅拌至溶解得到第四溶液；
    5)所述第一溶液、第二溶液、第三溶液和第四溶液混合后搅拌均匀，然后加入配方量的双氧水、三七提取液和侧柏叶提取液混合后搅拌均匀得到液体创可贴。
  5. 如权利要求4所述的制备方法，其特征在于：所述增塑剂为邻苯二甲酸二丁酯。
  6. 如权利要求4所述的制备方法，其特征在于：所述致孔剂为聚乙烯吡咯烷酮-醋酸乙烯酯共聚物。
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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1095665A1 (en) * 1998-07-07 2001-05-02 Nof Corporation Wound-covering preparation, wound-covering material, and method of wound healing
CN102406959A (zh) * 2011-11-29 2012-04-11 江苏德达医药科技有限公司 一种含有聚维酮碘的液体创口贴及其制备方法
CN102772801A (zh) * 2012-08-10 2012-11-14 江苏长泰药业有限公司 一种用于治疗擦伤的伤口喷雾剂及其制备方法
CN105816908A (zh) * 2016-04-29 2016-08-03 哈尔滨乾佰纳生物药业有限公司 一种防水型液体创口保护膜及其制备方法
CN110680879A (zh) * 2019-11-08 2020-01-14 西安千禾药业股份有限公司 一种活血止血祛腐生肌的中药喷膜剂及其制备方法
CN110975004A (zh) * 2019-12-10 2020-04-10 中山大学新华学院 一种含有三七提取液的快速成膜液体创可贴
CN111012943A (zh) * 2019-12-10 2020-04-17 中山大学新华学院 一种含有侧柏叶提取液的快速成膜液体创可贴
CN111195369A (zh) * 2020-01-20 2020-05-26 蓝佳堂生物医药（福建）有限公司 一种防水型液体创口敷料的制备方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1095665A1 (en) * 1998-07-07 2001-05-02 Nof Corporation Wound-covering preparation, wound-covering material, and method of wound healing
CN102406959A (zh) * 2011-11-29 2012-04-11 江苏德达医药科技有限公司 一种含有聚维酮碘的液体创口贴及其制备方法
CN102772801A (zh) * 2012-08-10 2012-11-14 江苏长泰药业有限公司 一种用于治疗擦伤的伤口喷雾剂及其制备方法
CN105816908A (zh) * 2016-04-29 2016-08-03 哈尔滨乾佰纳生物药业有限公司 一种防水型液体创口保护膜及其制备方法
CN110680879A (zh) * 2019-11-08 2020-01-14 西安千禾药业股份有限公司 一种活血止血祛腐生肌的中药喷膜剂及其制备方法
CN110975004A (zh) * 2019-12-10 2020-04-10 中山大学新华学院 一种含有三七提取液的快速成膜液体创可贴
CN111012943A (zh) * 2019-12-10 2020-04-17 中山大学新华学院 一种含有侧柏叶提取液的快速成膜液体创可贴
CN111195369A (zh) * 2020-01-20 2020-05-26 蓝佳堂生物医药（福建）有限公司 一种防水型液体创口敷料的制备方法

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