WO2022113931A1 - 歯質強化方法及び歯のホワイトニング方法 - Google Patents

歯質強化方法及び歯のホワイトニング方法 Download PDF

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Publication number
WO2022113931A1
WO2022113931A1 PCT/JP2021/042794 JP2021042794W WO2022113931A1 WO 2022113931 A1 WO2022113931 A1 WO 2022113931A1 JP 2021042794 W JP2021042794 W JP 2021042794W WO 2022113931 A1 WO2022113931 A1 WO 2022113931A1
Authority
WO
WIPO (PCT)
Prior art keywords
tooth
whitening
applying
strengthening
fluorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/042794
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English (en)
French (fr)
Japanese (ja)
Inventor
秀俊 西尾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nishio Co Ltd
Original Assignee
Nishio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nishio Co Ltd filed Critical Nishio Co Ltd
Priority to EP21897904.5A priority Critical patent/EP4252861A4/en
Priority to JP2022565319A priority patent/JP7549910B2/ja
Publication of WO2022113931A1 publication Critical patent/WO2022113931A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

Definitions

  • the present invention relates to a tooth structure strengthening method and a tooth whitening method including the tooth structure strengthening method.
  • the enamel on the tooth surface is the hardest tissue in the human body, and about 96% is made of crystals of hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), which is a kind of calcium phosphate. There is.
  • This hydroxyapatite is composed of calcium, phosphoric acid, and hydroxyl groups at the molecular level, but has the property of being weak against acids.
  • Plaque adheres to the surface of the tooth and the bacteria in the plaque are activated to generate acid.
  • the hydroxyapatite that composes the tooth enamel comes into contact with the acid, the hydroxyapatite crystals Calcium and phosphoric acid dissolve from the ingredients (decalcification), which causes tooth decay.
  • hydroxyapatite becomes fluoroapatite (Ca 110 (PO 4 ) 6 F 2 ) by fluorine, and enamel is strengthened by fluoroapatite having high acid resistance, and it becomes difficult for tooth decay to occur.
  • Patent Documents 1 to 3 cannot strengthen the tooth structure and cannot solve the problem that the teeth appear yellow due to thinning due to excessive brushing of the teeth.
  • the entire tooth surface is covered with a thin organic film called pellicle, and even if fluorine is applied to the tooth surface covered by this pellicle, the tooth structure is strengthened by fluorine. The effect is halved.
  • the present invention has been made in view of the above problems, and an object thereof is a dentin strengthening method capable of easily and effectively strengthening a dentin, and a dentin strengthening method for strengthening the dentin.
  • the purpose is to provide a tooth whitening method capable of whitening teeth.
  • the dentin strengthening method according to the present invention involves applying a solvent (14), which is a mixture of an agent containing calcium phosphate as a main component and saliva of the subject himself, to the surface of the tooth (1). It is a feature.
  • the reaction between the statusrin contained in saliva and the calcium contained in calcium phosphate promotes the remineralization of tooth enamel, and a strong calcified film is formed on the tooth surface to make the tooth substance effective. Will be strengthened. And such an effect can be easily obtained by simply applying a solvent to the tooth surface.
  • the solvent (14) may be applied to the surface of the tooth (1) and then fluorine (16) may be applied to the surface of the tooth (1).
  • the crystals of the strong calcified film formed on the tooth surface in the previous step are densified by fluorine, and the tooth surface is effectively protected by the densified and hardened strong calcified film. , This strengthens the tooth structure more effectively.
  • the pellicle (11) covering the tooth surface may be peeled off with a cleansing agent (12).
  • the effect of fluorine to strengthen the tooth structure is enhanced.
  • the effect of fluorine for strengthening the tooth structure is halved.
  • the tooth whitening method according to the present invention includes a first step of removing the pellicle (11) covering the tooth surface with a cleansing agent (12) and applying the whitening agent (13) to the surface of the tooth (1).
  • the second step the third step of applying the solvent (14) obtained by mixing the saliva of the subject to the agent containing calcium phosphate as the main component to the surface of the tooth (1), and the fluorine (16) being applied to the tooth (16). It is characterized in that the tooth (1) is whitened through a fourth step of applying to the surface of 1).
  • the pellicle covering the entire tooth surface is peeled off in the first step, and in the next second step, a whitening agent is applied to the tooth surface from which the pellicle has been peeled off to bleach the tooth (whitening). ).
  • a solvent obtained by mixing the saliva of the subject with the agent containing calcium phosphate as the main component to the tooth surface the statuslin contained in the saliva and the calcium contained in the calcium phosphate are formed.
  • the enamel crystals on the tooth surface are densified and the tooth structure is further refined. Be strengthened.
  • the teeth can be whitened while strengthening the tooth structure.
  • a tooth structure strengthening method capable of easily and effectively strengthening the tooth structure
  • a tooth whitening method capable of whitening the teeth while strengthening the tooth structure by this tooth structure strengthening method.
  • 1A to 1C are explanatory views showing the dentin strengthening method according to the present invention in the order of the steps.
  • 2A to 2D are explanatory views showing the tooth whitening method according to the present invention in the order of the steps.
  • FIGS. 1A to 1C are explanatory views showing the dentin strengthening method according to the present invention in the order of the steps, and in the present embodiment, the following three steps are sequentially executed.
  • FIG. 1A First step: In the first step, the thin pellicle (organic film) 11 covering the entire surface (tooth surface) of the tooth 1 is peeled off. Specifically, as shown in the figure, an acidic cleansing agent 12 is applied to the surface of the tooth 1 and exposed to light (laser light or plasma light), and then the peeled pellicle 11 and the excess cleansing agent 12 are treated with polyphosphoric acid. Wipe off with the liquid of. Then, the pellicle 11 covering the entire tooth surface is peeled off.
  • an acidic cleansing agent 12 is applied to the surface of the tooth 1 and exposed to light (laser light or plasma light), and then the peeled pellicle 11 and the excess cleansing agent 12 are treated with polyphosphoric acid. Wipe off with the liquid of. Then, the pellicle 11 covering the entire tooth surface is peeled off.
  • FIG. 1B Second step: In the second step, light (laser) is applied to the surface of the tooth 1 from which the pecryl 11 has been peeled off in the first step by applying a solvent 14 obtained by mixing the agent containing calcium phosphate as a main component with the saliva of the subject. Light or plasma light) is applied, and then the excess solvent 14 is wiped off with a polyphosphate liquid. Then, the surface of the tooth 1 is coated with the strong calcified film 15.
  • a solvent 14 obtained by mixing the agent containing calcium phosphate as a main component with the saliva of the subject. Light or plasma light
  • the calcium phosphate contained in the agent is a chemically bonded product of phosphoric acid (H 3 PO 4 ) and calcium (Ca).
  • H 3 PO 4 phosphoric acid
  • Ca calcium
  • FIG. 1C Third step: In the third step, fluorine 16 is applied to the surface of the tooth 1 coated with the strong calcification film 15 on the surface in the second step, and then the excess fluorine 16 is wiped off. Then, the crystals of the strong calcified film 15 coated on the surface of the tooth 1 are densified, and the tooth substance is further strengthened.
  • Fluoroapatite which has high acid resistance, strengthens enamel and makes it less likely to cause tooth decay.
  • the dentin strengthening method by sequentially carrying out the above first to third steps, the dentin can be effectively strengthened and the occurrence of tooth decay can be prevented.
  • the first step (peeling of the pellicle 11) and the third step (coating of fluorine 16) in the present embodiment are not essential steps, but may be appropriately carried out as needed.
  • FIGS. 2A to 2D are explanatory views showing the tooth whitening method according to the present invention in the order of the steps.
  • the teeth are whitened (bleached) through the following four steps. Tooth whitening.
  • the first, third, and fourth steps shown below are the same as the first, second, and third steps of FIG. 1 for explaining the tooth structure strengthening method, and the tooth according to the present embodiment.
  • the whitening method is performed between the first step (stripping of the pellicle 11) and the second step (formation of the strong calcified film 15 by applying the solvent 14) of FIG. 1 for explaining the tooth structure strengthening method.
  • a tooth whitening step is incorporated. That is, in the tooth whitening method according to the present embodiment, the following first to fourth steps are sequentially carried out.
  • FIG. 2A First step: Since this first step is the same as the first step (FIG. 1A) in the dentin strengthening method, the description thereof will be omitted again.
  • FIG. 2B Second step: In this second step, the whitening agent 13 obtained by adding sodium polyphosphate to hydrogen peroxide is applied to the surface of the tooth 1 from which the pellicle 11 has been peeled off from the surface in the first step. Then, the tooth 1 is bleached and whitened by the bleaching action of the whitening agent 13, and then the excess whitening agent 13 is wiped off from the surface of the tooth 1. As the whitening agent 13, any other whitening agent 13 can be used.
  • FIG. 2C Third step: In the third step, light (laser light or plasma) is applied to the surface of the tooth 1 that has become white in the second step by applying a solvent 14 obtained by mixing the saliva of the person to be treated with an agent containing calcium phosphate as a main component. Light) is applied, and then the excess solvent 14 is wiped off with a liquid of polyphosphate. Then, the surface of the tooth 1 is coated with the strong calcified film 15. Since this third step is the same as the second step of FIG. 1B described in the dentin strengthening method, further detailed description thereof will be omitted.
  • light laser light or plasma
  • FIG. 2D Fourth step: The fourth step is a step of applying fluorine 16 to the surface of the tooth 1 coated with the strong calcification film 15 on the surface in the third step, and then wiping off the excess fluorine 16. Since it is the same as the third step of FIG. 1C described in the strengthening direction, the description thereof will be omitted again.
  • the effect that the tooth 1 can be whitened while strengthening the tooth structure can be obtained.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Dental Preparations (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
PCT/JP2021/042794 2020-11-24 2021-11-22 歯質強化方法及び歯のホワイトニング方法 Ceased WO2022113931A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP21897904.5A EP4252861A4 (en) 2020-11-24 2021-11-22 Tooth strengthening method and tooth whitening method
JP2022565319A JP7549910B2 (ja) 2020-11-24 2021-11-22 歯質強化方法及び歯のホワイトニング方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020194765 2020-11-24
JP2020-194765 2020-11-24

Publications (1)

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WO2022113931A1 true WO2022113931A1 (ja) 2022-06-02

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PCT/JP2021/042794 Ceased WO2022113931A1 (ja) 2020-11-24 2021-11-22 歯質強化方法及び歯のホワイトニング方法

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EP (1) EP4252861A4 (cg-RX-API-DMAC7.html)
JP (1) JP7549910B2 (cg-RX-API-DMAC7.html)
TW (1) TWI792707B (cg-RX-API-DMAC7.html)
WO (1) WO2022113931A1 (cg-RX-API-DMAC7.html)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58219107A (ja) * 1982-03-10 1983-12-20 ザ・プロクタ−・エンド・ギヤンブル・カンパニ− 口腔衛生用製品
JPH07223930A (ja) * 1994-02-10 1995-08-22 Sumitomo Osaka Cement Co Ltd 歯磨組成物
JPH10510550A (ja) * 1995-08-08 1998-10-13 エナメロン・インコーポレイテッド 歯の病変部の再石灰化用の安定な一剤型組成物とその用途
JPH115722A (ja) * 1997-06-13 1999-01-12 Hideki Aoki 口腔内洗浄用水性組成物
JP2005263777A (ja) * 2004-02-19 2005-09-29 Meiji Seika Kaisha Ltd 口腔用組成物
JP2005263678A (ja) * 2004-03-18 2005-09-29 Kao Corp 歯のコーティング剤組成物
JP2006508892A (ja) 2002-03-13 2006-03-16 ゲィリー　ツァワー 歯のホワイトニング用具及び歯のホワイトニング方法
JP2008260702A (ja) * 2007-04-10 2008-10-30 Sangi Co Ltd 再石灰化促進剤及び口腔用組成物
JP2008542403A (ja) * 2005-06-07 2008-11-27 ザ ユニバーシティー オブ メルボルン 歯の石灰化
JP2009062397A (ja) 1998-11-12 2009-03-26 3M Co 歯科用ホワイトニング組成物を使用する歯のホワイトニング方法
JP2009268689A (ja) 2008-05-07 2009-11-19 Hitoshi Tamura 歯のホワイトニング方法

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US20080057007A1 (en) * 2006-03-01 2008-03-06 Dentech, Inc. Oral hygiene products containing ascorbic acid and method of using the same
US9226895B2 (en) * 2008-07-30 2016-01-05 Ultradent Products, Inc. Methods and kits for cleaning and remineralizing teeth
US20140113244A1 (en) * 2011-09-30 2014-04-24 Regenetiss, Inc. Tooth whitening composition containing colloidal platinum
WO2013181479A2 (en) * 2012-06-01 2013-12-05 Centrix, Inc. Protective wax for bleached teeth

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58219107A (ja) * 1982-03-10 1983-12-20 ザ・プロクタ−・エンド・ギヤンブル・カンパニ− 口腔衛生用製品
JPH07223930A (ja) * 1994-02-10 1995-08-22 Sumitomo Osaka Cement Co Ltd 歯磨組成物
JPH10510550A (ja) * 1995-08-08 1998-10-13 エナメロン・インコーポレイテッド 歯の病変部の再石灰化用の安定な一剤型組成物とその用途
JPH115722A (ja) * 1997-06-13 1999-01-12 Hideki Aoki 口腔内洗浄用水性組成物
JP2009062397A (ja) 1998-11-12 2009-03-26 3M Co 歯科用ホワイトニング組成物を使用する歯のホワイトニング方法
JP2006508892A (ja) 2002-03-13 2006-03-16 ゲィリー　ツァワー 歯のホワイトニング用具及び歯のホワイトニング方法
JP2005263777A (ja) * 2004-02-19 2005-09-29 Meiji Seika Kaisha Ltd 口腔用組成物
JP2005263678A (ja) * 2004-03-18 2005-09-29 Kao Corp 歯のコーティング剤組成物
JP2008542403A (ja) * 2005-06-07 2008-11-27 ザ ユニバーシティー オブ メルボルン 歯の石灰化
JP2008260702A (ja) * 2007-04-10 2008-10-30 Sangi Co Ltd 再石灰化促進剤及び口腔用組成物
JP2009268689A (ja) 2008-05-07 2009-11-19 Hitoshi Tamura 歯のホワイトニング方法

Non-Patent Citations (1)

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Title
See also references of EP4252861A4

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Publication number Publication date
JPWO2022113931A1 (cg-RX-API-DMAC7.html) 2022-06-02
EP4252861A4 (en) 2024-11-06
TW202220635A (zh) 2022-06-01
TWI792707B (zh) 2023-02-11
JP7549910B2 (ja) 2024-09-12
EP4252861A1 (en) 2023-10-04

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