WO2022092232A1 - 組成物及びその製造方法並びに化粧料 - Google Patents
組成物及びその製造方法並びに化粧料 Download PDFInfo
- Publication number
- WO2022092232A1 WO2022092232A1 PCT/JP2021/039903 JP2021039903W WO2022092232A1 WO 2022092232 A1 WO2022092232 A1 WO 2022092232A1 JP 2021039903 W JP2021039903 W JP 2021039903W WO 2022092232 A1 WO2022092232 A1 WO 2022092232A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- component
- acid
- salt
- group
- mass
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 114
- 239000002537 cosmetic Substances 0.000 title claims abstract description 49
- 238000004519 manufacturing process Methods 0.000 title claims description 23
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 150000002430 hydrocarbons Chemical group 0.000 claims description 97
- 150000003839 salts Chemical class 0.000 claims description 64
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 56
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 48
- 229930195729 fatty acid Natural products 0.000 claims description 48
- 239000000194 fatty acid Substances 0.000 claims description 48
- 239000002253 acid Substances 0.000 claims description 47
- 239000012044 organic layer Substances 0.000 claims description 45
- 125000002252 acyl group Chemical group 0.000 claims description 33
- 239000010410 layer Substances 0.000 claims description 30
- 238000006243 chemical reaction Methods 0.000 claims description 28
- 150000004665 fatty acids Chemical class 0.000 claims description 26
- 230000004580 weight loss Effects 0.000 claims description 23
- 238000001035 drying Methods 0.000 claims description 21
- 229920006395 saturated elastomer Polymers 0.000 claims description 20
- 150000001413 amino acids Chemical class 0.000 claims description 18
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 17
- 229910052783 alkali metal Inorganic materials 0.000 claims description 17
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 17
- 150000008065 acid anhydrides Chemical class 0.000 claims description 16
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 15
- 150000001412 amines Chemical class 0.000 claims description 14
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 13
- 150000001340 alkali metals Chemical class 0.000 claims description 12
- 229910052782 aluminium Inorganic materials 0.000 claims description 12
- 150000003862 amino acid derivatives Chemical class 0.000 claims description 12
- 229960001231 choline Drugs 0.000 claims description 12
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 12
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 11
- 239000004472 Lysine Substances 0.000 claims description 11
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 11
- 239000004475 Arginine Substances 0.000 claims description 10
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 10
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 10
- 229910052725 zinc Inorganic materials 0.000 claims description 10
- 239000011701 zinc Substances 0.000 claims description 10
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 8
- 229910052749 magnesium Inorganic materials 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 229930195733 hydrocarbon Natural products 0.000 claims description 6
- 239000004215 Carbon black (E152) Substances 0.000 claims description 5
- 239000012046 mixed solvent Substances 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229930195712 glutamate Natural products 0.000 claims description 4
- 150000001735 carboxylic acids Chemical class 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 238000003763 carbonization Methods 0.000 claims description 2
- 239000012074 organic phase Substances 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 abstract description 12
- 239000000839 emulsion Substances 0.000 abstract description 8
- -1 caproyl group Chemical group 0.000 description 120
- 235000002639 sodium chloride Nutrition 0.000 description 79
- 239000007787 solid Substances 0.000 description 68
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 63
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 54
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 52
- 125000004432 carbon atom Chemical group C* 0.000 description 52
- 239000007864 aqueous solution Substances 0.000 description 36
- 239000007788 liquid Substances 0.000 description 35
- 239000000284 extract Substances 0.000 description 32
- 238000004128 high performance liquid chromatography Methods 0.000 description 32
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 31
- 239000003921 oil Substances 0.000 description 30
- 235000019198 oils Nutrition 0.000 description 30
- 239000000126 substance Substances 0.000 description 28
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 26
- 239000000243 solution Substances 0.000 description 26
- AVBJHQDHVYGQLS-AWEZNQCLSA-N (2s)-2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-AWEZNQCLSA-N 0.000 description 23
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 23
- 238000000034 method Methods 0.000 description 22
- 239000012535 impurity Substances 0.000 description 21
- 238000003756 stirring Methods 0.000 description 21
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 20
- 229940024606 amino acid Drugs 0.000 description 20
- 235000001014 amino acid Nutrition 0.000 description 20
- 239000004166 Lanolin Substances 0.000 description 18
- 235000019388 lanolin Nutrition 0.000 description 18
- 229940039717 lanolin Drugs 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 17
- 239000000047 product Substances 0.000 description 17
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 15
- 239000005639 Lauric acid Substances 0.000 description 15
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 15
- 239000013078 crystal Substances 0.000 description 15
- 238000011156 evaluation Methods 0.000 description 15
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 14
- 229960002989 glutamic acid Drugs 0.000 description 14
- 159000000000 sodium salts Chemical class 0.000 description 14
- 235000009697 arginine Nutrition 0.000 description 13
- 235000019482 Palm oil Nutrition 0.000 description 12
- 229920002125 Sokalan® Polymers 0.000 description 12
- 239000004220 glutamic acid Substances 0.000 description 12
- 210000004209 hair Anatomy 0.000 description 12
- 239000002540 palm oil Substances 0.000 description 12
- 239000000843 powder Substances 0.000 description 12
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 11
- 230000006837 decompression Effects 0.000 description 11
- 235000013922 glutamic acid Nutrition 0.000 description 11
- 229920001296 polysiloxane Polymers 0.000 description 11
- 238000005917 acylation reaction Methods 0.000 description 10
- 239000006071 cream Substances 0.000 description 10
- 125000005645 linoleyl group Chemical group 0.000 description 10
- 229960003646 lysine Drugs 0.000 description 10
- 235000018977 lysine Nutrition 0.000 description 10
- 239000010445 mica Substances 0.000 description 10
- 229910052618 mica group Inorganic materials 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 9
- 150000003863 ammonium salts Chemical class 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 238000004945 emulsification Methods 0.000 description 9
- 238000005187 foaming Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 159000000003 magnesium salts Chemical class 0.000 description 9
- 239000003208 petroleum Substances 0.000 description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 8
- 150000001484 arginines Chemical class 0.000 description 8
- 229960001631 carbomer Drugs 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 8
- 239000006210 lotion Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 238000012790 confirmation Methods 0.000 description 7
- 239000003925 fat Substances 0.000 description 7
- 235000019197 fats Nutrition 0.000 description 7
- 235000021588 free fatty acids Nutrition 0.000 description 7
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 150000007942 carboxylates Chemical class 0.000 description 6
- 230000004087 circulation Effects 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 230000001804 emulsifying effect Effects 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 239000003346 palm kernel oil Substances 0.000 description 6
- 235000019865 palm kernel oil Nutrition 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 239000010936 titanium Substances 0.000 description 6
- 229910052719 titanium Inorganic materials 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- AVBJHQDHVYGQLS-UHFFFAOYSA-N 2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)NC(C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- 159000000007 calcium salts Chemical class 0.000 description 5
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 5
- 239000004359 castor oil Substances 0.000 description 5
- 235000019438 castor oil Nutrition 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
- HTDNEFOQUKDGBS-AWEZNQCLSA-N n-[(3s)-2,6-dioxooxan-3-yl]dodecanamide Chemical compound CCCCCCCCCCCC(=O)N[C@H]1CCC(=O)OC1=O HTDNEFOQUKDGBS-AWEZNQCLSA-N 0.000 description 5
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 5
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 5
- 238000007254 oxidation reaction Methods 0.000 description 5
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 229930195734 saturated hydrocarbon Natural products 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 5
- 229940098465 tincture Drugs 0.000 description 5
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- KODLUXHSIZOKTG-UHFFFAOYSA-N 1-aminobutan-2-ol Chemical class CCC(O)CN KODLUXHSIZOKTG-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000004381 Choline salt Substances 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- 235000015278 beef Nutrition 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 4
- 235000019417 choline salt Nutrition 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 4
- 238000004821 distillation Methods 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 150000002169 ethanolamines Chemical class 0.000 description 4
- 239000010419 fine particle Substances 0.000 description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 229910003002 lithium salt Inorganic materials 0.000 description 4
- 159000000002 lithium salts Chemical class 0.000 description 4
- 239000000155 melt Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- 230000007498 myristoylation Effects 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 159000000001 potassium salts Chemical class 0.000 description 4
- 150000003248 quinolines Chemical class 0.000 description 4
- 229960004889 salicylic acid Drugs 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 230000000475 sunscreen effect Effects 0.000 description 4
- 239000000516 sunscreening agent Substances 0.000 description 4
- 150000003751 zinc Chemical class 0.000 description 4
- 239000011787 zinc oxide Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 3
- 235000021360 Myristic acid Nutrition 0.000 description 3
- 235000021314 Palmitic acid Nutrition 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 238000003916 acid precipitation Methods 0.000 description 3
- 150000003973 alkyl amines Chemical class 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 235000003704 aspartic acid Nutrition 0.000 description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229940082500 cetostearyl alcohol Drugs 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 229940107161 cholesterol Drugs 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- 229940049906 glutamate Drugs 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 3
- 229910052744 lithium Inorganic materials 0.000 description 3
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 239000004584 polyacrylic acid Substances 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 3
- 239000005060 rubber Substances 0.000 description 3
- 239000008257 shaving cream Substances 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- GJBHGUUFMNITCI-QTNFYWBSSA-M sodium;(2s)-2-aminopentanedioate;hydron;hydrate Chemical compound O.[Na+].OC(=O)[C@@H](N)CCC([O-])=O GJBHGUUFMNITCI-QTNFYWBSSA-M 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 150000003871 sulfonates Chemical class 0.000 description 3
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- HFDVRLIODXPAHB-UHFFFAOYSA-N 1-tetradecene Chemical compound CCCCCCCCCCCCC=C HFDVRLIODXPAHB-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 2
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- GXCDLJXPZVCHBX-UHFFFAOYSA-N 3-methylpent-1-yn-3-yl carbamate Chemical compound CCC(C)(C#C)OC(N)=O GXCDLJXPZVCHBX-UHFFFAOYSA-N 0.000 description 2
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 2
- 235000021357 Behenic acid Nutrition 0.000 description 2
- 240000003538 Chamaemelum nobile Species 0.000 description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- 239000002211 L-ascorbic acid Substances 0.000 description 2
- 235000000069 L-ascorbic acid Nutrition 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N R-12-HOA Natural products CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 2
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 2
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 150000003855 acyl compounds Chemical class 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 125000005037 alkyl phenyl group Chemical group 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 229940116226 behenic acid Drugs 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- 229940073609 bismuth oxychloride Drugs 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 235000001046 cacaotero Nutrition 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000010495 camellia oil Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 229910000423 chromium oxide Inorganic materials 0.000 description 2
- VQWFNAGFNGABOH-UHFFFAOYSA-K chromium(iii) hydroxide Chemical compound [OH-].[OH-].[OH-].[Cr+3] VQWFNAGFNGABOH-UHFFFAOYSA-K 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 238000011033 desalting Methods 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- NQGIJDNPUZEBRU-UHFFFAOYSA-N dodecanoyl chloride Chemical compound CCCCCCCCCCCC(Cl)=O NQGIJDNPUZEBRU-UHFFFAOYSA-N 0.000 description 2
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 239000000118 hair dye Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 2
- 229960004068 hexachlorophene Drugs 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- HCZKYJDFEPMADG-UHFFFAOYSA-N nordihydroguaiaretic acid Chemical compound C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229960002969 oleic acid Drugs 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 description 2
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 229960001755 resorcinol Drugs 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 229960001153 serine Drugs 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- ZFDPAZDODACYOG-UHFFFAOYSA-M sodium;[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)amino]methanesulfonate Chemical compound [Na+].CN1C(C)=C(NCS([O-])(=O)=O)C(=O)N1C1=CC=CC=C1 ZFDPAZDODACYOG-UHFFFAOYSA-M 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- 229910001928 zirconium oxide Inorganic materials 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- FTSXCFQXTFOYQH-BDQAORGHSA-N (2s)-2-(octadecanoylamino)pentanedioic acid;sodium Chemical compound [Na].CCCCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O FTSXCFQXTFOYQH-BDQAORGHSA-N 0.000 description 1
- CRMQSOIOCWCNHM-KRWDZBQOSA-N (2s)-2-(tetradecylamino)pentanedioic acid Chemical compound CCCCCCCCCCCCCCN[C@H](C(O)=O)CCC(O)=O CRMQSOIOCWCNHM-KRWDZBQOSA-N 0.000 description 1
- LGQKSQQRKHFMLI-SJYYZXOBSA-N (2s,3r,4s,5r)-2-[(3r,4r,5r,6r)-4,5,6-trihydroxyoxan-3-yl]oxyoxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)OC1 LGQKSQQRKHFMLI-SJYYZXOBSA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical class COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 description 1
- BVIUYHQPSZOHOV-UHFFFAOYSA-N 1,1-dichloroethene;2-methylprop-2-enoic acid Chemical compound ClC(Cl)=C.CC(=C)C(O)=O BVIUYHQPSZOHOV-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- ZTBOHPVCZAACCS-UHFFFAOYSA-N 1,5,5-trichlorocyclohex-3-ene-1,2-diol Chemical compound OC1C=CC(Cl)(Cl)CC1(O)Cl ZTBOHPVCZAACCS-UHFFFAOYSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- RNHWYOLIEJIAMV-UHFFFAOYSA-N 1-chlorotetradecane Chemical compound CCCCCCCCCCCCCCCl RNHWYOLIEJIAMV-UHFFFAOYSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- DHGBAFGZLVRESL-UHFFFAOYSA-N 14-methylpentadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C DHGBAFGZLVRESL-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- COPFWAGBXIWZNK-UHFFFAOYSA-N 2,3-bis(6-methylheptanoyloxy)propyl 6-methylheptanoate Chemical compound CC(C)CCCCC(=O)OCC(OC(=O)CCCCC(C)C)COC(=O)CCCCC(C)C COPFWAGBXIWZNK-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 description 1
- ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 2,3-dimethylbutane Chemical group CC(C)C(C)C ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- JVXJFNLEXLGQIO-UHFFFAOYSA-N 2-hexyldecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CCCCCC)CCCCCCCC JVXJFNLEXLGQIO-UHFFFAOYSA-N 0.000 description 1
- KFCDDRTYJQZGKK-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enenitrile Chemical compound C=CC#N.CC(=C)C(O)=O KFCDDRTYJQZGKK-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- ACNUVXZPCIABEX-UHFFFAOYSA-N 3',6'-diaminospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(N)C=C1OC1=CC(N)=CC=C21 ACNUVXZPCIABEX-UHFFFAOYSA-N 0.000 description 1
- XFDUHJPVQKIXHO-UHFFFAOYSA-N 3-aminobenzoic acid Chemical compound NC1=CC=CC(C(O)=O)=C1 XFDUHJPVQKIXHO-UHFFFAOYSA-N 0.000 description 1
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 description 1
- LGQKSQQRKHFMLI-UHFFFAOYSA-N 4-O-beta-D-xylopyranosyl-beta-D-xylopyranose Natural products OC1C(O)C(O)COC1OC1C(O)C(O)C(O)OC1 LGQKSQQRKHFMLI-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241001237961 Amanita rubescens Species 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
- 235000012137 Atriplex confertifolia Nutrition 0.000 description 1
- 244000266618 Atriplex confertifolia Species 0.000 description 1
- 229910052582 BN Inorganic materials 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 description 1
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- RAFGELQLHMBRHD-VFYVRILKSA-N Bixin Natural products COC(=O)C=CC(=C/C=C/C(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)O)/C)C RAFGELQLHMBRHD-VFYVRILKSA-N 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- VQPYGYVVIRSWGN-UHFFFAOYSA-N C(CCCCCC)C(C(=O)O)CCCCCCCCC.OCC(O)CO.OCC(O)CO Chemical compound C(CCCCCC)C(C(=O)O)CCCCCCCCC.OCC(O)CO.OCC(O)CO VQPYGYVVIRSWGN-UHFFFAOYSA-N 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- VQAWRQZAAIQXHM-UHFFFAOYSA-N Cepharanthine Natural products O1C(C=C2)=CC=C2CC(C=23)N(C)CCC3=CC=3OCOC=3C=2OC(=CC=23)C(OC)=CC=2CCN(C)C3CC2=CC=C(O)C1=C2 VQAWRQZAAIQXHM-UHFFFAOYSA-N 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 235000010919 Copernicia prunifera Nutrition 0.000 description 1
- 244000180278 Copernicia prunifera Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- RDFLLVCQYHQOBU-GPGGJFNDSA-O Cyanin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@H](CO)O1)c1c(-c2cc(O)c(O)cc2)[o+]c2c(c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O3)cc(O)c2)c1 RDFLLVCQYHQOBU-GPGGJFNDSA-O 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- SQNRKWHRVIAKLP-UHFFFAOYSA-N D-xylobiose Natural products O=CC(O)C(O)C(CO)OC1OCC(O)C(O)C1O SQNRKWHRVIAKLP-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 239000004287 Dehydroacetic acid Substances 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- ILKBHIBYKSHTKQ-UHFFFAOYSA-N Diisopropylamine dichloroacetate Chemical compound OC(=O)C(Cl)Cl.CC(C)NC(C)C ILKBHIBYKSHTKQ-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 244000058871 Echinochloa crus-galli Species 0.000 description 1
- 235000008247 Echinochloa frumentacea Nutrition 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241001553290 Euphorbia antisyphilitica Species 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- KIENGQUGHPTFGC-JLAZNSOCSA-N L-ascorbic acid 6-phosphate Chemical compound OP(=O)(O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O KIENGQUGHPTFGC-JLAZNSOCSA-N 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- QWZLBLDNRUUYQI-UHFFFAOYSA-M Methylbenzethonium chloride Chemical compound [Cl-].CC1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 QWZLBLDNRUUYQI-UHFFFAOYSA-M 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- 235000009134 Myrica cerifera Nutrition 0.000 description 1
- QZXSMBBFBXPQHI-UHFFFAOYSA-N N-(dodecanoyl)ethanolamine Chemical compound CCCCCCCCCCCC(=O)NCCO QZXSMBBFBXPQHI-UHFFFAOYSA-N 0.000 description 1
- PSFABYLDRXJYID-VKHMYHEASA-N N-Methylserine Chemical compound CN[C@@H](CO)C(O)=O PSFABYLDRXJYID-VKHMYHEASA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- YPIGGYHFMKJNKV-UHFFFAOYSA-N N-ethylglycine Chemical compound CC[NH2+]CC([O-])=O YPIGGYHFMKJNKV-UHFFFAOYSA-N 0.000 description 1
- 108010065338 N-ethylglycine Proteins 0.000 description 1
- PSFABYLDRXJYID-UHFFFAOYSA-N N-methyl-DL-serine Natural products CNC(CO)C(O)=O PSFABYLDRXJYID-UHFFFAOYSA-N 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 241000580955 Sapindus mukorossi Species 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 235000002953 Saxifraga stolonifera Nutrition 0.000 description 1
- 244000288377 Saxifraga stolonifera Species 0.000 description 1
- 229940122511 Sebum inhibitor Drugs 0.000 description 1
- 244000061457 Solanum nigrum Species 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 235000006732 Torreya nucifera Nutrition 0.000 description 1
- 244000111306 Torreya nucifera Species 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- RKFMOTBTFHXWCM-UHFFFAOYSA-M [AlH2]O Chemical compound [AlH2]O RKFMOTBTFHXWCM-UHFFFAOYSA-M 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- JHIDGGPPGFZMES-UHFFFAOYSA-N acetic acid;n-(2-aminoethyl)hydroxylamine Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.NCCNO JHIDGGPPGFZMES-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- 229920006322 acrylamide copolymer Polymers 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- RAFGELQLHMBRHD-UHFFFAOYSA-N alpha-Fuc-(1-2)-beta-Gal-(1-3)-(beta-GlcNAc-(1-6))-GalNAc-ol Natural products COC(=O)C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC(O)=O RAFGELQLHMBRHD-UHFFFAOYSA-N 0.000 description 1
- 150000004645 aluminates Chemical class 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 229960002298 aminohydroxybutyric acid Drugs 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229960000510 ammonia Drugs 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229940072049 amyl acetate Drugs 0.000 description 1
- 239000001670 anatto Substances 0.000 description 1
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 235000012665 annatto Nutrition 0.000 description 1
- 125000005427 anthranyl group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000013793 astaxanthin Nutrition 0.000 description 1
- 239000001168 astaxanthin Substances 0.000 description 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
- 229910001863 barium hydroxide Inorganic materials 0.000 description 1
- 239000013040 bath agent Substances 0.000 description 1
- 235000012677 beetroot red Nutrition 0.000 description 1
- 239000001654 beetroot red Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 235000002185 betanin Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- HGKOWIQVWAQWDS-UHFFFAOYSA-N bis(16-methylheptadecyl) 2-hydroxybutanedioate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCCCCCCCCCC(C)C HGKOWIQVWAQWDS-UHFFFAOYSA-N 0.000 description 1
- RAFGELQLHMBRHD-SLEZCNMESA-N bixin Chemical compound COC(=O)\C=C\C(\C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C(O)=O RAFGELQLHMBRHD-SLEZCNMESA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229960002645 boric acid Drugs 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 235000012682 canthaxanthin Nutrition 0.000 description 1
- FDSDTBUPSURDBL-DKLMTRRASA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-DKLMTRRASA-N 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 229940008396 carrot extract Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- YVPXVXANRNDGTA-WDYNHAJCSA-N cepharanthine Chemical compound C1C(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2C[C@H](C2=C3)N(C)CCC2=CC(OC)=C3OC2=C(OCO3)C3=CC3=C2[C@H]1N(C)CC3 YVPXVXANRNDGTA-WDYNHAJCSA-N 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 229910000428 cobalt oxide Inorganic materials 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000008294 cold cream Substances 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 239000000973 cosmetic coloring agent Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- RDFLLVCQYHQOBU-ZOTFFYTFSA-O cyanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=[O+]C1=CC(O)=C2)C=3C=C(O)C(O)=CC=3)=CC1=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 RDFLLVCQYHQOBU-ZOTFFYTFSA-O 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- 229940061632 dehydroacetic acid Drugs 0.000 description 1
- 235000019258 dehydroacetic acid Nutrition 0.000 description 1
- JEQRBTDTEKWZBW-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1=C(O)OC(C)=CC1=O JEQRBTDTEKWZBW-UHFFFAOYSA-N 0.000 description 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229960005215 dichloroacetic acid Drugs 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- PFKRTWCFCOUBHS-UHFFFAOYSA-N dimethyl(octadecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[NH+](C)C PFKRTWCFCOUBHS-UHFFFAOYSA-N 0.000 description 1
- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical class C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 description 1
- 108700003601 dimethylglycine Proteins 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 229960001483 eosin Drugs 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229940007062 eucalyptus extract Drugs 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 1
- YQGDEPYYFWUPGO-UHFFFAOYSA-N gamma-amino-beta-hydroxybutyric acid Chemical compound [NH3+]CC(O)CC([O-])=O YQGDEPYYFWUPGO-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 159000000011 group IA salts Chemical class 0.000 description 1
- 229960002350 guaiazulen Drugs 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- ZFSXZJXLKAJIGS-UHFFFAOYSA-N halocarban Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)NC=2C=CC(Cl)=CC=2)=C1 ZFSXZJXLKAJIGS-UHFFFAOYSA-N 0.000 description 1
- 229950006625 halocarban Drugs 0.000 description 1
- 239000008269 hand cream Substances 0.000 description 1
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 description 1
- GQXQIRNPJBUEGY-UHFFFAOYSA-N hexadecan-7-yl 2,2-dimethyloctanoate Chemical compound CCCCCCCCCC(CCCCCC)OC(=O)C(C)(C)CCCCCC GQXQIRNPJBUEGY-UHFFFAOYSA-N 0.000 description 1
- HSEMFIZWXHQJAE-UHFFFAOYSA-N hexadecanamide Chemical compound CCCCCCCCCCCCCCCC(N)=O HSEMFIZWXHQJAE-UHFFFAOYSA-N 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- DWMMZQMXUWUJME-UHFFFAOYSA-N hexadecyl octanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC DWMMZQMXUWUJME-UHFFFAOYSA-N 0.000 description 1
- CBCIHIVRDWLAME-UHFFFAOYSA-N hexanitrodiphenylamine Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O CBCIHIVRDWLAME-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 125000002510 isobutoxy group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])O* 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940075495 isopropyl palmitate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000003903 lactic acid esters Chemical class 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960002285 methylbenzethonium chloride Drugs 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229940042472 mineral oil Drugs 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- QEALYLRSRQDCRA-UHFFFAOYSA-N myristamide Chemical compound CCCCCCCCCCCCCC(N)=O QEALYLRSRQDCRA-UHFFFAOYSA-N 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- 229940078490 n,n-dimethylglycine Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- LYRFLYHAGKPMFH-UHFFFAOYSA-N octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(N)=O LYRFLYHAGKPMFH-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- 239000004306 orthophenyl phenol Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- FURYAADUZGZUGQ-UHFFFAOYSA-N phenoxybenzene;sulfuric acid Chemical class OS(O)(=O)=O.C=1C=CC=CC=1OC1=CC=CC=C1 FURYAADUZGZUGQ-UHFFFAOYSA-N 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229940067631 phospholipid Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- DQAKJEWZWDQURW-UHFFFAOYSA-N pyrrolidonecarboxylic acid Chemical class OC(=O)N1CCCC1=O DQAKJEWZWDQURW-UHFFFAOYSA-N 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 230000021148 sequestering of metal ion Effects 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 229960005349 sulfur Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229940069762 swertia japonica extract Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 150000005621 tetraalkylammonium salts Chemical group 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940095068 tetradecene Drugs 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- KVSKGMLNBAPGKH-UHFFFAOYSA-N tribromosalicylanilide Chemical compound OC1=C(Br)C=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 KVSKGMLNBAPGKH-UHFFFAOYSA-N 0.000 description 1
- 229950001807 tribromsalan Drugs 0.000 description 1
- PMBRBOODEWULOI-UHFFFAOYSA-N trichloromethanide Chemical compound Cl[C-](Cl)Cl PMBRBOODEWULOI-UHFFFAOYSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 235000020240 turmeric extract Nutrition 0.000 description 1
- 239000008513 turmeric extract Substances 0.000 description 1
- 229940052016 turmeric extract Drugs 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- LTBBHPKPFHCPTL-UHFFFAOYSA-L zinc;carbonotrithioate Chemical compound [Zn+2].[S-]C([S-])=S LTBBHPKPFHCPTL-UHFFFAOYSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/22—Amides or hydrazides
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/28—Aminocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/32—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
Definitions
- the present invention relates to a composition (particularly a cosmetic raw material composition), a method for producing the same, and a cosmetic.
- Patent Document 1 discloses that a gel-like composition containing an acyl group-containing amino acid derivative is a composition having excellent stability and usability.
- Patent Document 2 discloses a technique relating to contribution to formulation stability, antiseptic effect and hypoallergenicity in cosmetics by blending an acyl group-containing amino acid derivative.
- an object of the present invention is to provide a composition (particularly a cosmetic raw material composition) that imparts excellent emulsion stability and dispersion stability.
- the present inventors have obtained excellent emulsion stability and dispersion stability by combining an acyl group-containing amino acid derivative having a specific structure with various components. It has been found that the composition to be imparted can be provided.
- composition / component A characterized by containing: Acyl group-containing amino acid derivative represented by the following general formula (A) or a salt thereof.
- R1 and R2 are independently saturated or unsaturated linear or branched hydrocarbon groups, respectively.
- M1, M2, and M3 are each independently a hydrogen atom, an alkali metal, an alkaline earth metal, an organic or inorganic amine, a basic amino acid, choline, aluminum, or zinc.
- n1 and n2 are 0 and 2 or 2 and 0. n3 and n4 are 0 and 2 or 2 and 0) -Component B: N-acylpyrrolidone carboxylic acid represented by the following general formula (B) or a salt thereof.
- R3 is a saturated or unsaturated linear or branched hydrocarbon group.
- M4 is a hydrogen atom, alkali metal, alkaline earth metal, organic or inorganic amine, basic amino acid, choline, aluminum, or zinc
- -Component C Acylglutamic acid represented by the following general formula (C) or a salt thereof.
- R4 is a saturated or unsaturated linear or branched hydrocarbon group.
- M5 and M6 are independently hydrogen atoms, alkali metals, alkaline earth metals, organic or inorganic amines, basic amino acids, choline, aluminum, or zinc).
- -Component D Fatty acid represented by the following general formula (D) or a salt thereof.
- R5 is a saturated or unsaturated linear or branched hydrocarbon group.
- M7 is a hydrogen atom, alkali metal, alkaline earth metal, organic or inorganic amine, basic amino acid, choline, aluminum, or zinc
- -Component E Fatty acid amide represented by the following general formula (E) (In formula (E), R6 is a saturated or unsaturated linear or branched hydrocarbon group).
- [7] The composition according to any one of [1], [2], [4], [5] and [6], wherein the ratio of the component B to the component A is 0.004% or more.
- the amount of the component C is 0.8% by mass or more based on the total mass of the component A and the component C.
- the amount of the component D is 0.06% by mass or more based on the total mass of the component A and the component D.
- [9] The composition according to any one of [1] and [3] to [8], wherein the amount of the component E is 0.005% by mass or more based on the mass of the component A.
- composition that imparts excellent emulsion stability and dispersion stability.
- the present embodiment a mode for carrying out the present invention (hereinafter, simply referred to as “the present embodiment”) will be described in detail.
- the following embodiments are examples for explaining the present invention, and are not intended to limit the present invention to the following contents.
- the present invention can be appropriately modified and carried out within the scope of the gist thereof.
- composition In this embodiment, one or more components selected from the group consisting of the following component A, the following component B, the following component C, the following component D, and the following component E (however, only the component C or only the component D are used. (Excluding), and a composition characterized by containing (particularly a cosmetic raw material composition) and a cosmetic containing the same.
- Examples of the combination of components include A + B, A + E, A + B + C, A + B + D, A + B + E, A + C + D, A + C + E, A + B + C + D, A + B + C + E, and A + C + D + E.
- the component A is an acyl group-containing amino acid derivative represented by the following general formula (A) or a salt thereof.
- R1 and R2 are independently saturated or unsaturated linear or branched hydrocarbon groups, respectively.
- M1, M2, and M3 are each independently a hydrogen atom, an alkali metal, an alkaline earth metal, an organic or inorganic amine, a basic amino acid, or choline.
- n1 and n2 are 0 and 2 or 2 and 0.
- n3 and n4 are 0 and 2 or 2 and 0)
- the component B is an N-acylpyrrolidone carboxylic acid represented by the following general formula (B) or a salt thereof.
- component B is also referred to as "acyl PCA”.
- R3 is a saturated or unsaturated linear or branched hydrocarbon group.
- M4 is a hydrogen atom, alkali metal, alkaline earth metal, organic or inorganic amine, basic amino acid, or choline)
- the component C is acylglutamic acid represented by the following general formula (C) or a salt thereof.
- R4 is a saturated or unsaturated linear or branched hydrocarbon group.
- M5 and M6 are independently hydrogen atoms, alkali metals, alkaline earth metals, organic or inorganic amines, basic amino acids, or choline).
- the component D is a fatty acid represented by the following general formula (D) or a salt thereof.
- R5 is a saturated or unsaturated linear or branched hydrocarbon group.
- M7 is a hydrogen atom, alkali metal, alkaline earth metal, organic or inorganic amine, basic amino acid, or choline)
- the component E is a fatty acid amide represented by the following general formula (E).
- R6 is a saturated or unsaturated linear or branched hydrocarbon group).
- the cosmetic raw material composition of the present embodiment can impart a high degree of initial emulsification stability and dispersion stability to a cosmetic formulation, and can also impart a good usability.
- R1 and R2 in the general formula (A) can be used without being limited to the types of saturated, unsaturated, linear and branched chains as long as they are hydrocarbon groups.
- R1 and R2 independently have a hydrocarbon group having 9 carbon atoms, a hydrocarbon group having 11 carbon atoms, a hydrocarbon group having 13 carbon atoms, a hydrocarbon group having 15 carbon atoms, and a hydrocarbon having 17 carbon atoms. It may be a group, a hydrocarbon group having 19 carbon atoms, or a hydrocarbon group having 21 carbon atoms.
- Hydrocarbon groups commonly distributed in the world such as isostearoyl group, oleyl group, linoleyl group, linoleyl group, arachidyl group and behenyl group can also be used, and compositions derived from palm oil, palm kernel oil and palm oil can also be used. Mixed hydrocarbon groups can also be used.
- the three carboxylic acid groups of the acyl group-containing amino acid derivative represented by the general formula (A) may be all free carboxylic acids, all may be carboxylates, or may be a combination of free carboxylic acids and carboxylates. ..
- the carboxylate (COOM1, COOM2, COMM3) in the general formula (A) is not particularly limited, but is, for example, an alkali metal salt such as a sodium salt, a potassium salt, a lithium salt, a magnesium salt, or a calcium salt, or an alkaline earth metal.
- sodium salts, potassium salts, magnesium salts, triethanolamine salts and arginines are preferable, and sodium salts are more preferable.
- the content of the component A is preferably 0.003 to 3% by mass, more preferably 0.01 to 2% by mass, and 0.02 to 0, based on the mass of the cosmetic raw material composition. It is more preferably 5.5% by mass.
- R3 in the general formula (B) can be used without being limited to the types of saturated, unsaturated, linear and branched chains as long as it is a hydrocarbon group.
- R3 has a hydrocarbon group having 9 carbon atoms, a hydrocarbon group having 11 carbon atoms, a hydrocarbon group having 13 carbon atoms, a hydrocarbon group having 15 carbon atoms, a hydrocarbon group having 17 carbon atoms, and a hydrocarbon group having 19 carbon atoms. It may be a hydrocarbon group or a hydrocarbon group having 21 carbon atoms.
- the carboxylate (COM4) in the general formula (B) is not particularly limited, and is, for example, an alkali metal salt such as a sodium salt, a potassium salt, a lithium salt, a magnesium salt, or a calcium salt, or an alkaline earth metal salt; an ammonium salt.
- the ratio of the component B to the component A is preferably 0.004% or more and 7.0% or less. , More preferably 0.01% or more and 3.5% or less, and further preferably 0.02% or more and 2.0% or less.
- the content of component B is 0.004% or more, the emulsifying property and emulsifying stability in the prescription system are further improved, and when the content of component B is 7.0% or less, the dissolution stability of the prescription system is improved. Further improve.
- the ratio can be measured by the HPLC analysis method described in the examples below.
- the content of the component B is preferably 0.00003 to 0.03% by mass, more preferably 0.0001 to 0.02% by mass, and 0, based on the mass of the cosmetic raw material composition. It is more preferably .0002 to 0.005% by mass.
- R4 in the general formula (C) can be used without being limited to the types of saturated, unsaturated, linear and branched chains as long as it is a hydrocarbon group.
- R4 has a hydrocarbon group having 9 carbon atoms, a hydrocarbon group having 11 carbon atoms, a hydrocarbon group having 13 carbon atoms, a hydrocarbon group having 15 carbon atoms, a hydrocarbon group having 17 carbon atoms, and a hydrocarbon group having 19 carbon atoms. It may be a hydrocarbon group or a hydrocarbon group having 21 carbon atoms.
- the carboxylate (COOM5, COM6) in the general formula (C) is not particularly limited, and is, for example, an alkali metal salt such as a sodium salt, a potassium salt, a lithium salt, a magnesium salt, or a calcium salt, or an alkaline earth metal salt; Amin salts (organic or inorganic ammonium salts) such as ammonium salts, alkylamine salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, aminomethylpropanol salts; basic amino acid salts such as lysine salts and arginine salts, choline salts. , Aluminum salt, zinc salt and the like, may be used alone or in admixture. From the viewpoint of performance and availability, sodium salts, potassium salts, magnesium salts, triethanolamine salts and arginines are preferable, and sodium salts are more preferable.
- the content (%) of the component C is preferably 0.8% by mass or more, and preferably 0.8% by mass or more and 8.0% by mass or less, based on the total mass of the component A and the component C. It is more preferably 1.1% by mass or more and 8.0% by mass or less, and particularly preferably 1.5% by mass or more and 6.0% by mass or less.
- the above ratio can be measured by the method described in the following Examples.
- R5 in the general formula (D) can be used without being limited to the types of saturated, unsaturated, linear and branched chains as long as it is a hydrocarbon group.
- R5 has a hydrocarbon group having 9 carbon atoms, a hydrocarbon group having 11 carbon atoms, a hydrocarbon group having 13 carbon atoms, a hydrocarbon group having 15 carbon atoms, a hydrocarbon group having 17 carbon atoms, and a hydrocarbon group having 19 carbon atoms. It may be a hydrocarbon group or a hydrocarbon group having 21 carbon atoms.
- the carboxylate (COM7) in the general formula (D) is not particularly limited, and is, for example, an alkali metal salt such as a sodium salt, a potassium salt, a lithium salt, a magnesium salt, or a calcium salt, or an alkaline earth metal salt; an ammonium salt.
- the content (%) of the component D is preferably 0.06% by mass or more, and preferably 0.06% by mass or more and 3.0% by mass or less, based on the total mass of the component A and the component D. It is more preferably 0.11% by mass or more and 3.0% by mass or less, and particularly preferably 0.14% by mass or more and 0.55% by mass or less.
- the above ratio can be measured by the method described in the following Examples.
- R6 in the general formula (E) can be used without being limited to the types of saturated, unsaturated, linear and branched chains as long as it is a hydrocarbon group.
- R6 has a hydrocarbon group having 9 carbon atoms, a hydrocarbon group having 11 carbon atoms, a hydrocarbon group having 13 carbon atoms, a hydrocarbon group having 15 carbon atoms, a hydrocarbon group having 17 carbon atoms, and a hydrocarbon having 19 carbon atoms. It may be a hydrocarbon group or a hydrocarbon group having 21 carbon atoms.
- the ratio of the component E to the component A is 0.005% by mass or more. It is preferably 00% by mass or less, more preferably 0.02% by mass or more and 3.00% by mass or less, and further preferably 0.08% by mass or more and 0.6% by mass or less.
- the ratio can be measured by the method described in the following Examples.
- the pH of the cosmetic raw material composition of the present embodiment and the cosmetic containing the same is not particularly limited, but is preferably 4.0 to 9.0, and more preferably 4.5 to 8.5. , More preferably 5.0 to 8.0.
- M1 to M7 in the formulas (A) to (D) are independently selected from the group consisting of a hydrogen atom, sodium, lithium, potassium, magnesium, ammonium, triethanolamine, and arginine.
- M1 to M7 are independently selected from the group consisting of hydrogen atom, sodium, lithium, potassium, magnesium, ammonium, triethanolamine, and arginine, and at least one of M1 to M7 is hydrogen, and M1 to M7. More preferably, at least one of them is selected from the group consisting of sodium, lithium, potassium, magnesium, ammonium, triethanolamine, and arginine. It is more preferred that M1 to M7 are each independently hydrogen or sodium, at least one of M1 to M7 is hydrogen, and at least one of M1 to M7 is sodium.
- the method for producing the composition of the present embodiment includes the following steps. 1) [First step] In a mixed solvent containing water and an organic solvent, glutamate or a salt thereof is reacted with fatty acid chloride to obtain a reaction solution containing N-acylglutamic acid or a salt thereof, and the reaction solution is used. A step of setting the pH to 1 to 6 with an acid and separating the organic layer and the aqueous layer at a temperature of 25 to 80 ° C.
- acylation reaction step of the present embodiment glutamate and fatty acid chloride are subjected to a condensation reaction in the presence of an alkaline compound in a mixed solvent of water and an organic solvent such as t-butanol, acetone, methyl ethyl ketone and isopropanol. It is a step, and crude N-acylglutamic acid is produced by the acylation reaction.
- the molar ratio of fatty acid chloride to glutamic acid is preferably 1.05 or less, more preferably 1.0 or less, still more preferably 0.98 or less.
- the amount of free fatty acid produced tends to be easily reduced.
- the composition of the mixed solvent preferably has a volume ratio of water / organic solvent in the range of 90/10 to 20/80, more preferably in the range of 85/15 to 50/50. be.
- the range is in the range of 90/10 to 20/80, glutamic acid, the fatty acid chloride and the alkaline compound are easily compatible with each other, and the reaction rate can be increased.
- the concentration of glutamic acid charged in the acylation reaction step is not particularly limited, but since the viscosity of the reaction solution increases over time during the reaction, the concentration is adjusted to a level that allows stirring and mixing when the reaction is nearing completion. Is preferable.
- the reaction temperature of the acylation reaction step is not particularly limited, but is preferably in the range of ⁇ 10 to 70 ° C., more preferably in the range of ⁇ 10 to 20 ° C., and further, from the viewpoint of promoting the main reaction and suppressing side reactions. It is preferably in the range of ⁇ 5 to 10 ° C.
- the alkaline compound used in the acylation reaction step is not particularly limited, and examples thereof include inorganic bases such as sodium hydroxide, potassium hydroxide, calcium hydroxide, and barium hydroxide.
- the pH in the acylation reaction step is preferably maintained in the range of 9 to 13.5, more preferably in the range of 10 to 13, from the viewpoint of promoting the main reaction and suppressing the side reaction.
- the acylation reaction solution has a pH of 1 to 6 with an acid (preferably a mineral acid) such as hydrochloric acid or sulfuric acid, and is separated into two layers, an organic layer and an aqueous layer, to obtain an organic layer.
- an acid preferably a mineral acid
- the produced N-acylglutamic acid is present in the form of an alkaline salt.
- the dissociation state of the carboxyl group changes depending on the pH at the time of acid precipitation, that is, the mass ratio between the organic layer and the aqueous layer and the removability of inorganic salts slightly change, it is preferable to carry out at pH 1 to 3. More preferably, the pH is 1 to 2.5.
- the temperature in the acid precipitation step is preferably 25 to 80 ° C. More preferably, it is 40 to 70 ° C. When the temperature is 25 ° C. or higher, the time until the equilibrium is reached can be shortened, and when the equilibrium is reached, the residual amount of the inorganic salt in the organic layer tends to be reduced.
- the organic layer obtained in the first step is concentrated and dried under acidic conditions to convert a part of N-acylglutamic acid into N-acylpyrrolidone carboxylic acid (component B).
- Concentration drying is preferably carried out under normal pressure or reduced pressure by heating. Concentration drying is carried out until the drying weight loss is preferably 10% by mass or less, more preferably 3% by mass or less, and further preferably 1% by mass or less. Since acylglutamic acid is anhydrousized in the next step, it is preferable that the amount of drying weight is small in order to reduce the water content.
- the concentrated drying it is preferable to distill off the organic solvent and water under normal pressure or reduced pressure at a temperature higher than the boiling point of the organic solvent at the beginning or near the co-boiling point of the organic solvent and water to be used.
- the mass ratio of the organic solvent to water is substantially 3% or less, the coexisting acylglutamic acid tends to foam, so careful depressurization control while heating is required. Even if the organic solvent is almost distilled off, the water still remains, and as a practical operation, the depressurization can be continued near the boiling point of water.
- the above operation requires foaming control, that is, gentle stirring adapted to the foaming condition, as compared with the freeze-drying method in which the mixture is kept standing at a set temperature, but the amount of acylglutamic acid is about 10% by mass or less and 85.
- An appropriate amount of acyl PCA can be produced as a by-product at a high temperature of ° C. or higher, which can be used for emulsifying property and dispersibility in the formulation system.
- freeze-drying treatment is used as an operation. Almost no foaming occurs during the treatment, and it is convenient because it is not performed by humans in the drying operation, but acyl PCA is not seen.
- the ultimate decompression degree is preferably 50 kPa or less, and more preferably 20 kPa or less.
- the ultimate temperature depends on the melting point and the degree of reduced pressure of the acylglutamic acid, but is preferably 70 ° C. or higher, more preferably 95 ° C. or higher, still more preferably 105 ° C. or higher.
- component B acyl PCA
- acyl PCA acyl PCA
- the preferred dehydrating agent is an anhydrous carboxylic acid such as acetic anhydride, and it is preferable to use acetic anhydride from the viewpoint of economy and environment.
- acetic anhydride from the viewpoint of economy and environment.
- excess acetic anhydride and acetic acid are removed by filtration.
- it can be washed with ether and then petroleum ether, and then dried to obtain a solid substance mainly composed of the acylglutamic acid anhydride.
- the cosmetics in the present invention are a general term for non-pharmaceutical products and cosmetics referred to in the Pharmaceutical Machinery Law. , Hair remover, hair dye, permanent wave agent, bath agent, medicated cosmetics, medicated toothpaste, etc. can be listed, and cosmetics include cosmetic soap, face wash (cream / paste, liquid / gel).
- the cosmetic raw material composition of the present embodiment can be used in combination with various base materials according to the intended use and purpose as long as the object of the present invention is not impaired.
- natural rubbers such as Arabica rubber and tragant rubber, glucosides such as saponin, cellulose derivatives such as methylcellulose, carboxycellulose and hydroxymethylcellulose, natural polymers such as ligninsulfonate and cellac, polyacrylic acid salts, etc.
- Anionic polymers such as styrene-acrylic acid copolymer salt, vinylnaphthalene-maleic acid copolymer salt, ⁇ -naphthalenesulfonic acid formarin condensate sodium salt, phosphate, polyvinyl alcohol, polyvinylpyrrolidone, etc.
- Dispersants such as nonionic polymers such as polyethylene glycol;
- Higher fatty acid salt (soap), salt of higher fatty acid having 8 to 20 carbon atoms in the hydrophobic base, N-acylamino acid type anionic surfactant As the acyl group, those having 8 to 20 carbon atoms as described above are used.
- the constituent amino acids include the above-mentioned acidic amino acids such as glutamic acid and aspartic acid, or glycine, alanine, valine, leucine, isoleucine, proline, methionine, cysteine, tryptophan, tyrosine, phenylalanine, asparagine, glutamine, serine and treonine.
- Oxyproline ⁇ -aminopropionic acid, ⁇ -aminobutyric acid, anthranyl acid, m-aminobenzoic acid, p-aminobenzoic acid and other amino acids, alkyl ether carboxylate, amide ether carboxylate and the like, alkyl sulfate esters Salt (AS), polyoxyethylene alkyl ether sulfate ester (AES), alkyl ether sulfate, higher fatty acid ester sulfate, higher fatty acid alkyrrole amide sulfate, sulfated fats and oils, polyoxyethylene styrenated phenyl ether sulfate Salts, alpha-olefin sulfonates (AOS), alkylbenzene sulfonates, alkylnaphthalene sulfonates, alkyl sulfonates (SAS), dialkyl sulfos, al
- Amphoteric surfactants such as alkyl betaines, alkylamide betaines, alkylsulfobetaines, imidazolinium betaines, betaines acetate, lecithins; Polyoxyethylene alkyl ether (AE), polyoxyethylene alkylphenyl ether, polyoxyethylene polystyrylphenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, polyoxyalkylene fatty acid ester, polyoxyalkylene Ethylene oxide condensed type such as sorbitan fatty acid ester, polyoxyalkylene fatty acid alkanolamide, polyoxyalkylene alkyl glucoside, polyoxyalkylene cured castor oil, polyoxyalkylene alkylamine, polyoxyalkylene alkyl phenyl ether, polyhydric alcohol fatty acid partial ester, Polyoxyethylene polyhydric alcohol fatty acid partial ester, polyoxyethylene fatty acid ester, (
- alkylammonium chloride salts tetraalkylammonium salts, trialkylbenzylammonium salts, alkylpyridinium salts, alkylhydroxyethylimidazolinium salts, dialkylmorpholinium salts, alkylisoquinolium salts, Cationic surfactants such as benzethonium salt and benzalconium salt;
- Polymer surfactants such as sodium alginate, starch derivatives, tragant rubber; Natural surfactants such as phospholipids, lecithin, lanolin, cholesterol and saponins;
- Hydrocarbons such as liquid paraffin, petrolatum, ceresin, microcrystalline wax, isoparaffin, zokerite, squalene, pristane, and squalane; Mitsurou, Whale Row, Lanolin, Carnauba Row, Candelilla Row, Cotton Row, Bayberry Row, Ibotaro, Montan Row, Nukarou, Lanolin, Caboc Row, Lanolin Acetate, Liquid Lanolin, Satoukibiro, Lanolin Fatty Acid Isopropyl, Hexil Laurate, Reduced Lanolin, Jojobaro , Hard lanolin, serrac wax, polyoxyethylene lanolin alcohol ether, polyoxyethylene lanolin alcohol acetate, lanolin fatty acid polyethylene glucol, polyoxyethylene hydrogenated lanolin alcohol ether and waxes thereof;
- Lauric acid myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, behenic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, soft lanolin fatty acid, linolenic acid, linolenic acid, eicosapentaenoic acid, 12-hydroxystearic acid
- Fatty acids such as; Higher alcohols such as lauryl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyldecanol, octyldodecanol; Sterols such as cholesterol and phytosterols;
- Alkylglycines such as N-methylglycine, N, N-dimethylglycine, N, N, N-trimethylglycine, N-ethylglycine, glycylbetaine, sorbitol, raffinose, pyrrolidone carboxylates, lactates, hyaluronates.
- Ceramides trehalose, xylobiose, maltose, sucrose, glucose, (poly) saccharides such as vegetable mucilage polysaccharides and derivatives thereof, glycosaminoglycans such as water-soluble chitin, chitosan, pectin, chondroitin sulfate and salts thereof, and Amino acids such as salts, glycine, serine, threonine, alanine, aspartic acid, tyrosine, valine, leucine, arginine, glutamine, prophosphate and their salts, sugar amino acid compounds such as aminocarbonyl reactants, plants such as aloe and malonie.
- Moisturizers such as extracts, urea, uric acid, ammonia, glucosamine, creatinine, DNA, RNA and other amino acid-related substances;
- Hydroxyethyl cellulose carboxymethyl cellulose, hydroxyethyl cellulose hydroxypropyltrimethylammonium chloride ether, methylcellulose, ethylcellulose, hydroxypropylcellulose, methylhydroxypropylcellulose, soluble starch, carboxymethyl starch, methyl starch, alginate propylene glycol ester, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl Methyl ether, carboxyvinyl polymer, polyacrylic acid salt, guar gum, locust bin gum, quince seed, carrageenan, galactan, arabic gum, pectin, mannan, starch, xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid, gelatin, casein , Albumin, collagen, methoxyethylene maleic anhydride copolymer, amphoteric methacrylic acid ester copolymer, polydimethylmethylene piperidinium, polyacrylic
- Oil gelling agents such as dextrin fatty acid ester, glycerin fatty acid ester, hydroxystearic acid;
- Metal ion sequestering agents such as ethylenediamine tetraacetic acid and its salts, hydroxyethylenediamine triacetic acid and its salts, phosphoric acid, ascorbic acid, succinic acid, gluconic acid, polyphosphates, metaphosphates, hinokityls;
- Paraoxybenzoic acid esters benzoic acid and its salts, phenoxyethanol, hinokityl, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, parachlormethacresol, hexachlorophene, boric acid, resorcin, tribromsalan, Orthophenylphenol, Tiram, Photosensitizer No.
- PH regulators such as citric acid, malic acid, adipic acid, glutamic acid, aspartic acid;
- Other anti-dandruff and anti-itch agents such as trichlorocarbanilide, salicylic acid, zinc pyrithione, and isopropylmethylphenol;
- Ascorbic acid and its salts alkali metal salts such as sodium salt, potassium salt, magnesium salt, calcium salt, alkaline earth metal salt, ammonium salt, amino acid salt, etc.
- ascorbic acid derivative L-ascorbic acid alkyl ester
- L-ascorbic acid phosphate ester and its salt L-ascorbic acid-2-sulfate ester and its salt
- alkoxysalicylic acid and its salt alkoxy groups include, for example, methoxy group and ethoxy group).
- Blood circulation promoters such as Swertia japonica extract, cepharanthin, vitamin E and its derivatives, gamma-oryzanol; Local stimulants such as tincture tincture, tincture shoyo, tincture cantalis tincture, and benzyl ester of nicotinic acid; Nutritional supplements such as various vitamins and amino acids; Female hormones; Hair root activator;
- Anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhizic acid derivatives, allantoin, azulene, aminocaproic acid, hydrocortisone; Astringents such as zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum chloride, aluminum sulfate, zinc sulfocarbonate, tannic acid, citric acid, lactic acid; Cooling agents such as menthol and camphor; Antihistamines such as diphenhydramine hydrochloride, chlorpheniramine maleate, and glycyrrhizic acid derivatives;
- Antioxidants such as tocopherols, BHA, BHT, gallic acid, NDGA; Sebum inhibitors such as estradiol, estrone, ethinyl estradiol; Exfoliating / dissolving agents such as sulfur, salicylic acid, resorcin; ⁇ -Hydroxy acids such as glycolic acid, lactic acid, malic acid, tartaric acid, citric acid; ⁇ -hydroxyl acid such as salicylic acid;
- sericite such as talc, kaolin, sericite, calcium carbonate, zinc oxide, aluminum oxide, magnesium oxide, zirconium oxide, magnesium carbonate, calcium carbonate, barium sulfate, chromium oxide, chromium hydroxide, tar pigment, etc.
- the various values in the examples may be preferable lower limit values or upper limit values in the embodiment of the present invention, and include the same kind of values (lower limit value and upper limit value in the numerical range) in the above-described embodiment of the present invention. ) May be appropriately combined to obtain a preferable numerical range. Further, two values of the same type in the examples may be appropriately combined to form a preferable numerical range.
- the component weight ratio of solid content / t-butanol / water mainly composed of acyl glutamic acid (lauroyl glutamic acid and myristyl glutamic acid) in the organic layer was 62/27/11.
- ⁇ HPLC analysis method> In Examples and Comparative Examples containing the following component B, component A and component B were measured from the peak area area obtained by the analysis using the following HPLC.
- Detector UV detector (205nm)
- As the measuring device for example, SPD-10Avp, SPD-10AVbp, SPD-20A, SPD-20AV, etc. of Shimadzu Corporation can be used.
- Separation tube A stainless steel tube having an inner diameter of 6 mm and a length of 150 mm was filled with silica gel having a particle size of 5 ⁇ m and a pore diameter of 12 nm modified with an octadecylsilyl group.
- Separation tube temperature Constant temperature around 60 ° C
- Flow rate Quantitative around 0.8 mL / min
- the component ratio was calculated from the peak area area of each of the detected substances such as component A and component B obtained by analysis using HPLC.
- the obtained dry weight loss was subtracted from the total component ratio of 100%, and the subtracted value was distributed by the peak area ratio obtained by HPLC analysis.
- the component B ratio (%) was calculated by the following formula. Corresponds to "Component B ratio (%)" in the table below.
- Component B ratio (%) [Peak area area of component B / Peak area area of component A] x 100
- Example 1 100 g of an organic layer having a solid content / t-butanol / water component weight ratio of 62/24/14 such as lauroyl glutamic acid obtained in Production Example 1 is gently stirred until the liquid temperature reaches 90 ° C. The temperature was raised at normal pressure. After that, the temperature was gradually increased while reducing the pressure, and the degree of decompression was gradually increased so as not to cause excessive foaming. At the reached decompression degree of 20 kPa, the reached temperature of 105 ° C. was maintained for 20 minutes. After that, the pressure was gradually returned to normal pressure, and the melt in the kettle was recovered.
- the obtained solid matter was placed in a refrigerator overnight and pulverized by a juicer mixer, and as a result, 56.6 g of the solid matter was obtained.
- the dry weight loss of this solid was 0.25%, and the results of HPLC analysis showed that it was 94.9% lauroyl glutamic acid, 3.7% lauroyl PCA, and 0.44% lauric acid. No other significant impurities were detected.
- the organic layer and the aqueous layer were separated, and the organic layer was separated from the organic layer. Most of the unreacted lysine is recovered in the aqueous layer.
- the solvent was removed from the obtained organic layer so that the obtained organic layer became an aqueous solution having a solid content of 30% by mass and a pH of 7 (25 ° C) with sodium hydroxide. Prepared in Japanese. Further, the distillation was carried out under reduced pressure while adding water, and the distillation under reduced pressure was continued until the concentration of tertiary butanol in the liquid became 10 mass ppm or less at a vacuum degree of 13 to 22 kPa and a liquid temperature of 45 to 60 ° C.
- the final product was a 32% by weight aqueous solution having a pH of 7 (25 ° C.) mainly containing the acyl compound represented by the formula (A), with 96.9% for component A and 96.9% for component B.
- the PCA was 0.031% and the lauroyl glutamic acid was 2.98%. No other significant impurities were detected.
- the acyl PCA (%) ratio by the above-mentioned HPLC analysis method was 0.032%.
- the obtained solid matter was in the form of a plate, which was pulverized with a juicer mixer to obtain 57.1 g of the solid matter.
- the dry weight loss of this solid was 1.2%, and as a result of HPLC analysis, lauroyl glutamic acid was 98.1%, lauroyl PCA was not detected, and lauric acid was 0.40%. No other significant impurities were detected.
- Example 2 115.0 g of the organic layer having a solid content / acetone / water component weight ratio of 55/30/15 such as lauroyl glutamic acid obtained in Production Example 2 is gently stirred until the liquid temperature reaches 50 ° C. The temperature is raised by pressure. After that, the temperature was gradually increased while reducing the pressure, and the degree of decompression was gradually increased so as not to cause excessive foaming. The ultimate decompression degree was 20 kPa and the ultimate temperature reached 105 ° C. The ultimate decompression degree was 20 kPa, and the ultimate temperature of 105 ° C. was maintained for 80 minutes. After that, the pressure was gradually returned to normal pressure, and the melt in the kettle was recovered.
- the obtained solid matter was in the form of a plate, which was pulverized with a juicer mixer to obtain 59.5 g of the solid matter.
- the dry weight loss of this solid was 0.51%, and as a result of HPLC analysis, 98.9% of lauroyl glutamic acid, lauroyl PCA and lauric acid were not detected. No other significant impurities were detected.
- Example 3 The liquid temperature reaches 70 ° C. while gently stirring 100.0 g of the organic layer having a solid content / t-butanol / water component weight ratio of 62/27/11 such as acyl glutamic acid obtained in Production Example 3.
- the temperature is raised at normal pressure until the temperature rises. After that, the temperature was gradually increased while reducing the pressure, and the degree of decompression was gradually increased so as not to cause excessive foaming.
- the ultimate decompression degree was 20 kPa, and the ultimate temperature reached 115 ° C., which was maintained for 20 minutes. After that, the pressure was gradually returned to normal pressure, and the melt in the kettle was recovered.
- the obtained solid matter was placed in a refrigerator overnight and pulverized by a juicer mixer, and as a result, 55.5 g of the solid matter was obtained.
- the dry weight loss of this solid was 0.14%, and as a result of HPLC analysis, acylglutamic acid was 90.9%, acyl PCA was 7.7%, and free fatty acids (lauric acid and myristic acid total) were 0.74%. .. No other significant impurities were detected.
- the obtained solid matter was in the form of a plate, which was pulverized with a juicer mixer to obtain 57.2 g of the solid matter.
- the dry weight loss of this solid was 0.61%, and as a result of HPLC analysis, acyl glutamic acid was 98.6%, acyl PCA was not detected, and free fatty acid was 0.54%. No other significant impurities were detected.
- Example 4 The same operation as in Production Example 1 was separately carried out to obtain an organic layer having a solid content / t-butanol / water component weight ratio of 64/25/11 such as lauroyl glutamic acid. While gently stirring 125 g of this organic layer, the temperature was raised at normal pressure until the liquid temperature reached 90 ° C. After that, the temperature was gradually increased while reducing the pressure, and the degree of decompression was gradually increased so as not to cause excessive foaming. At the reached decompression degree of 40 kPa, the reached temperature of 105 ° C. was maintained for 120 minutes. After that, the pressure was gradually returned to normal pressure, and the melt in the kettle was recovered.
- 64/25/11 such as lauroyl glutamic acid
- the obtained solid matter was placed in a refrigerator overnight and pulverized by a juicer mixer, and as a result, 70.6 g of the solid matter was obtained.
- the dry weight loss of this solid was 0.20%, and as a result of HPLC analysis, it was 80.7% lauroyl glutamic acid, 14.1% lauroyl PCA, and 4.7% lauric acid. No other significant impurities were detected.
- the organic layer and the aqueous layer were separated, and the organic layer was separated from the organic layer. Most of the unreacted lysine is recovered in the aqueous layer.
- the solvent was removed from the obtained organic layer so that the obtained organic layer became an aqueous solution having a solid content of 30% by mass and a pH of 7 (25 ° C) with sodium hydroxide. Prepared in Japanese. Further, the distillation was carried out under reduced pressure while adding water, and the distillation under reduced pressure was continued until the concentration of tertiary butanol in the liquid became 10 mass ppm or less at a vacuum degree of 13 to 22 kPa and a liquid temperature of 45 to 60 ° C.
- the finally obtained product was a 32% by weight aqueous solution having a pH of 7 (25 ° C.) mainly containing a composition containing an acyl compound represented by the formula (A), with 91.2% of component A and an acyl of component B.
- PCA was 6.25% and lauroyl glutamic acid was 2.32%. No other significant impurities were detected.
- the acyl PCA (%) ratio by the above-mentioned HPLC analysis method was 6.85%.
- ⁇ HPLC analysis method and solid content measurement method> When calculating the ratio of component C and component D to component A, the purity was calculated from the peak area area obtained by the analysis using the following HPLC.
- Detector RI detector Separation tube: A stainless steel tube having an inner diameter of 6 mm and a length of 150 mm was filled with silica gel having a particle size of 5 ⁇ m and a pore size of 12 nm modified with an octadecylsilyl group.
- Component C / Component A + C [Pure content of component C (g) / Pure content of component A (g) + Pure content of component C (g)] x 100 (%)
- Component D / Component A + D [Pure content of component D (g) / Pure content of component A (g) + Pure content of component D (g)] x 100 (%)
- ⁇ Preparation of high-purity component A> The following operation was carried out using the freeze-dried product (moisture of 2.0%) of Pericea L-30 manufactured by Asahi Kasei Finechem Co., Ltd. or the freeze-dried product produced by changing the acid chloride in Example 1 as a raw material.
- the freeze-dried product, distilled water and tertiary butanol are stirred at a weight ratio of 45/33/22 at 60 ° C. After reaching 60 ° C., sulfuric acid is slowly added, and sulfuric acid is continued to be added at 65 ° C. until the pH reaches 2, and after 30 minutes, stirring is stopped and the mixture is allowed to stand. After standing for 30 minutes, the separated lower layer (water layer) was removed.
- the lower layer (aqueous layer) is weighed, the same weight of a 20 wt% tertiary butanol aqueous solution (tershary butanol / distilled water weight ratio of 2/8) is added to the upper layer, and the mixture is stirred at 60 ° C. After 30 minutes, stop stirring and let stand for 30 minutes. The lower layer is excluded again. After injecting a 20 wt% tertiary butanol aqueous solution having the same weight as the above-mentioned lower layer, the steps of stirring, standing, and removing the lower layer (washing and desalting step) were repeated two more times, for a total of three times. The organic layer that had been washed with water and desalted was freeze-dried.
- a 20 wt% tertiary butanol aqueous solution tershary butanol / distilled water weight ratio of 2/8
- the dried product was washed and dried at room temperature with 100 ml of ether and then with 50 ml of petroleum ether. This was carried out again to obtain component A. This was analyzed by the above-mentioned HPLC, but other components having a peak ratio of 0.1% or more were not detected.
- the dried product was washed and dried at room temperature with 120 ml of ether and then with 60 ml of petroleum ether. This was repeated to obtain component C. This was analyzed by the above-mentioned HPLC, but other components having a peak ratio of 0.1% or more were not detected.
- Caprylic acid (O0027), lauric acid (L0011), myristic acid (M0476), palmitic acid (P1145), stearic acid (S0163), and behenic acid (B1248) were obtained from Tokyo Chemical Industry Co., Ltd.
- LC-MS analysis method In Examples and Comparative Examples, the purity of component E was confirmed by analysis using the following LC-MS.
- ⁇ HPLC analysis method> When calculating the ratio of component E to component A in Examples and Comparative Examples, the purity was confirmed by analysis using the following HPLC.
- Detector UV detector (205nm)
- As the measuring device for example, SPD-10Avp, SPD-10AVbp, SPD-20A, SPD-20AV, etc. of Shimadzu Corporation can be used.
- Separation tube A stainless steel tube having an inner diameter of 6 mm and a length of 150 mm was filled with silica gel having a particle size of 5 ⁇ m and a pore diameter of 12 nm modified with an octadecylsilyl group.
- component E / component A [Pure content of component E (g) / Pure content of component A (g)] x 100 (%)
- the cocamide MEA used in Examples and Comparative Examples was Amizole CME of Kawaken Fine Chemical Co., Ltd.
- Lauramide MEA was Amizole LME of Kawaken Fine Chemical Co., Ltd.
- Examples 27, 30, 33, 36, 42, 45, 48, 51, 54, 57, 60, 63, 66, 69, 72, 75, 78, 81, 84, 87 are the 32% aqueous solution of Example 1.
- 28, 31, 34, 37, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 76, 79, 82, 85, 88 are 32% aqueous solutions of Example 2.
- 29, 32, 35, 38, 44, 47, 50, 53, 56, 59, 62, 65, 68, 71, 74, 77, 80, 83, 86, 89 are 32% of Example 4.
- the aqueous solution and the above-mentioned high-purity component A, component C, component D, and component E were mixed and prepared so as to have the counter salt and pH shown in the table.
- high-purity components A and C to E are accurately weighed, and the obtained solid powder can be used as a counter salt in sodium hydroxide, potassium hydroxide, triethanolamine, or arginine.
- These aqueous solutions were finally adjusted to the specified pH and solid content of 32%.
- Example 9 In Comparative Examples 7 to 9, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, component A was replaced with the same amount of polysorbate 60, and the ratio of component B to component E was polysorbate. It is described as the ratio when 60 is the component A.
- Example 9 1% sodium stearoyl glutamic acid was added, and in Example 10, 3% myristic acid and 2% palmitic acid were added in place of purified water.
- composition wt% -32% aqueous solution of Example or Comparative Example 0.09 ⁇ Oil (ethylhexyl palmitate, olive oil, mineral oil, cyclomethicone, dimethicone) 20.0 ⁇ Carbo-mer (Carbo-mer 981) 0.2 ⁇ 30 wt / v% NaOH aqueous solution 0.28 ⁇ Purified water 79.43
- the above composition is as follows. ⁇ 4.
- Depends on the order of production 1. 1. Dissolve the carbomer in purified water. 2. 2. Adjust the pH of the carbomer aqueous solution to the specified pH with KOH or triethanolamine or arginine or NaOH aqueous solution. 3. 3. Add the 32% aqueous solution of Example or Comparative Example and the respective oils. 4. Emulsify at room temperature for 5 minutes using a homomixer (6000 rpm).
- composition wt% -32% aqueous solution of Example or Comparative Example 0.09 ⁇ Mineral oil (5,8-8.9 mm2 / s) 16.0 ⁇ Solid oil (cetostearyl alcohol, myristyl alcohol) 4.0 ⁇ Carbo-mer (Carbo-mer 981) 0.2 ⁇ 30 wt / v% NaOH aqueous solution 0.28 ⁇ Purified water 79.43
- the above composition is as follows. ⁇ 4.
- the carbomer is dissolved in purified water, and the carbomer aqueous solution is adjusted to the specified pH with KOH, triethanolamine, arginine, or NaOH aqueous solution.
- 2. The 32% aqueous solution of Example or Comparative Example and purified water are added to prepare an aqueous phase. This is heated to 70 ° C. 3.
- 3. Using mineral oil and solid oil as oil phases, heat to 70 ° C. 4.
- the aqueous phase and the oil phase are mixed, and the temperature is raised by stirring with a homomixer at 3000 rpm to 80 ° C. 5.
- Emulsify with a homomixer at 6000 rpm for 5 minutes. 6. Stir and cool to 25 ° C. with a homomixer at 3000 rpm. 7.
- Degas Degas.
- the above composition was stored at 55 ° C. and allowed to stand for 2 months, 2.5 months, and 3.0 months, and the emulsifying property was visually confirmed.
- Evaluation Criterion 5 Emulsified over the entire liquid depth. 4: More than 90% of the liquid depth is emulsified. 3: More than 80% of the liquid depth is emulsified. 2: More than 70% of the liquid depth is emulsified. 1: The emulsified liquid depth is less than 70%
- Titanium oxide was added to each of the 0.0075% solid content aqueous solutions of Examples and Comparative Examples so as to have a concentration of 1%, and KOH, triethanolamine, arginine, or an aqueous solution of NaOH was added so as to have a specified pH. .. Then, ultrasonic treatment was carried out for 30 seconds, homogenized (10000 rpm, 2 minutes), and then the absorbance (wavelength 300 nm) of the supernatant liquid when allowed to stand at 50 ° C. was measured, and the dispersibility in water was confirmed. The initial absorbance values of all of them were around 1.8, and the following evaluations were carried out by measuring the absorbance after 200 hours, 224 hours and 248 hours.
- composition of the example contains at least components A and B, components A, C and D, or components A and E, the emulsion stability, dispersion stability and usability evaluation were all good.
- the comparative example was a composition not corresponding to the invention, both the emulsion stability and the dispersion stability were inferior to those of the example.
- the cosmetic raw material composition according to the present invention it is possible to provide an excellent cosmetic formulation having good emulsification stability and dispersibility for a long period of time as well as initial emulsification performance and dispersion performance. ..
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
Description
[1]
下記成分Aと、
下記成分B、下記成分C、下記成分D及び下記成分Eからなる群から選択される1種以上の成分(ただし、前記成分Cのみ、又は前記成分Dのみは除く)と、
を含有することを特徴とする組成物
・成分A:下記一般式(A)で表されるアシル基含有アミノ酸誘導体又はその塩
R1及びR2は、各々独立に、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M1、M2、及びM3は、各々独立に、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛であり、
n1及びn2は、0及び2であるか、又は2及び0であり、
n3及びn4は、0及び2であるか、又は2及び0である)
・成分B:下記一般式(B)で表されるN-アシルピロリドンカルボン酸又はその塩
R3は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M4は、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛である)
・成分C:下記一般式(C)で表されるアシルグルタミン酸又はその塩
R4は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M5及びM6は、各々独立に、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛である)
・成分D:下記一般式(D)で表される脂肪酸又はその塩
R5は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M7は、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛である)
・成分E:下記一般式(E)で表される脂肪酸アミド
R6は、飽和又は不飽和の直鎖又は分枝状の炭化水素基である)。
[2]
前記成分Aと、前記成分Bとを含有する、[1]に記載の組成物。
[3]
前記成分Aと、前記成分Eとを含有する、[1]に記載の組成物。
[4]
前記成分Aと、前記成分Bと、前記成分Eとを含有する、[1]に記載の組成物。
[5]
前記一般式(A)~(E)におけるR1~R6が、各々独立に、炭化数1~29の炭化水素基である、[1]~[4]のいずれかに記載の組成物。
[6]
前記一般式(A)~(D)におけるM1~M7が、各々独立に、Na、K、トリエタノールアミン、Mg、Ca、Al、Zn、アルギニン、又はHである、[1]~[5]のいずれかに記載の組成物。
[7]
前記成分Bの、前記成分Aに対する割合が、0.004%以上である、[1]、[2]、[4]、[5]及び[6]のいずれかに記載の組成物。
[8]
前記成分Cの量が、前記成分Aと前記成分Cとの合計質量を基準として、0.8質量%以上であり、
前記成分Dの量が、前記成分Aと前記成分Dとの合計質量を基準として、0.06質量%以上である、
[1]及び[5]~[7]のいずれかに記載の組成物。
[9]
前記成分Eの量が、、前記成分Aの質量を基準として、0.005質量%以上である、[1]及び[3]~[8]のいずれかに記載の組成物。
[10]
以下の工程を含む、[1]、[2]及び[4]~[9]のいずれかに記載の組成物の製造方法:
1)水と有機溶媒とを含む混合溶媒中で、グルタミン酸又はその塩と脂肪酸クロライドとを反応させて、N-アシルグルタミン酸又はその塩を含む反応液を得、前記反応液を酸でpH1~6とし、25~80℃の温度において有機層と水層とに分層する工程;
2)前記有機層を酸性下で濃縮乾燥し、前記N-アシルグルタミン酸又はその塩の一部をN-アシルピロリドンカルボン酸又はその塩に変換する工程;
3)前記N-アシルグルタミン酸又はその塩と酸無水物とを反応させて、N-アシルグルタミン酸無水物を得る工程;及び
4)前記N-アシルグルタミン酸無水物とリジン又はその塩とを反応させて、アシル基含有アミノ酸誘導体又はその塩を得る工程。
[11]
前記工程2)において、前記有機相を、乾燥減量が10質量%以下になるまで濃縮乾燥する、[10]に記載の製造方法。
[12]
前記工程2)における濃縮乾燥を減圧下にて、50℃以上で実施する、[10]又は[11]に記載の製造方法。
[13]
香粧品原料組成物である、[1]~[9]のいずれかに記載の組成物。
[14]
[1]~[9]のいずれかに記載の組成物の香粧品原料としての使用。
[15]
[1]~[9]のいずれかに記載の組成物を配合した化粧料。
[16]
pH4以上である、[15]に記載の化粧料。
本実施形態のは、下記成分Aと、下記成分B、下記成分C、下記成分D及び下記成分Eからなる群から選択される1種以上の成分(ただし、成分Cのみ、又は成分Dのみは除く)と、を含有することを特徴とする組成物(特に香粧品原料組成物)及びこれを配合した化粧料に関する。成分の組み合わせとしては、例えば、A+B、A+E、A+B+C、A+B+D、A+B+E、A+C+D、A+C+E、A+B+C+D、A+B+C+E、A+C+D+Eが挙げられる。
R1及びR2は、各々独立に、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M1、M2、及びM3は、各々独立に、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、又はコリンであり、
n1及びn2は、0及び2であるか、又は2及び0であり、
n3及びn4は、0及び2であるか、又は2及び0である)
R3は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M4は、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、又はコリンである)
R4は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M5及びM6は、各々独立に、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、又はコリンである)
R5は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M7は、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、又はコリンである)
M1~M7は、各々独立に、水素原子、ナトリウム、リチウム、カリウム、マグネシウム、アンモニウム、トリエタノールアミン、及びアルギニンからなる群から選ばれ、M1~M7の少なくとも1つが、水素であり、M1~M7の少なくとも1つが、ナトリウム、リチウム、カリウム、マグネシウム、アンモニウム、トリエタノールアミン、及びアルギニンからなる群から選ばれることがより好ましい。
M1~M7は、各々独立に、水素又はナトリウムであり、M1~M7の少なくとも1つが、水素であり、M1~M7の少なくとも1つが、ナトリウムであることが更に好ましい。
本実施形態の組成物(特に香粧品原料組成物)の製造方法は、以下の工程を含む。
1)[第一工程]水と有機溶媒とを含む混合溶媒中で、グルタミン酸又はその塩と脂肪酸クロライドとを反応させて、N-アシルグルタミン酸又はその塩を含む反応液を得、前記反応液を酸でpH1~6とし、25~80℃の温度において有機層と水層とに分層する工程。
2)[第二工程]前記有機層を酸性下で濃縮乾燥し、前記N-アシルグルタミン酸又はその塩の一部をN-アシルピロリドンカルボン酸又はその塩(成分B)に変換する工程。
3)[第三工程]前記N-アシルグルタミン酸又はその塩と酸無水物とを反応させて、N-アシルグルタミン酸無水物を得る工程。
4)[第四工程]前記N-アシルグルタミン酸無水物とリジン又はその塩とを反応させて、アシル基含有アミノ酸誘導体又はその塩(成分A)を得る工程。
本実施形態のアシル化反応工程は、水と、例えばt-ブタノール、アセトン、メチルエチルケトン、イソプロパノール等の有機溶媒との混合溶媒中で、アルカリ性化合物の存在下で、グルタミン酸と脂肪酸クロライドとを縮合反応する工程であり、アシル化反応により、粗N-アシルグルタミン酸が生成する。
本発明形態の第二工程は、第一工程で得られた有機層を、酸性下で濃縮乾燥し、N-アシルグルタミン酸の一部をN-アシルピロリドンカルボン酸(成分B)に変換する。濃縮乾燥は、加温して、常圧下または減圧下で実施することが好ましい。濃縮乾燥は、乾燥減量が、好ましくは10質量%以下、より好ましくは3質量%以下、さらに好ましくは1質量%以下になるまで実施する。次工程でアシルグルタミン酸を無水物化するので、水分を減らすために、乾燥減量は少ない方が好ましい。
乾燥減量(%)=[{初期試料質量(g)-乾燥試料質量(g)}/初期試料質量(g)]×100
この工程にて、例えば、操作としては、凍結乾燥処理を用いる。処理中に殆ど発泡が生じず、乾燥操作上は人的には何ら実施することは無いので簡便であるが、アシルPCAは見られない。
第二工程で得られたアシルグルタミン酸主体の固形物に、無水酢酸のような無水カルボン酸を反応させ、得られた反応液よりろ別・乾燥して、アシルグルタミン酸無水物主体の粗結晶を得ることができる。
第三工程で得られたアシルグルタミン酸無水物主体の固形物を、特許第4070768号公報に準じて、アシルグルタミン酸無水物2モル当量に対してリジンが1モル当量となるように、反応させて、後述に示すような、主成分が一般式(A)で表されるアシル基含有アミノ酸誘導体の水溶液を作製することができる。
具体的には、アラビアゴム、トラガントゴム等の天然ゴム類、サポニン等のグルコシド類、メチルセルロース、カルボキシセルロース、ヒドロキシメチルセルロース等のセルロース誘導体、リグニンスルホン酸塩、セラック等の天然高分子、ポリアクリル酸塩、スチレン-アクリル酸共重合物の塩、ビニルナフタレン-マレイン酸共重合物の塩、β-ナフタレンスルホン酸ホルマリン縮合物のナトリウム塩、リン酸塩などの陰イオン性高分子やポリビニルアルコール、ポリビニルピロリドン、ポリエチレングリコール等のノニオン性高分子等の分散剤;
ポリオキシエチレンアルキルエーテル(AE)、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンポリスチリルフェニルエーテル、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシアルキレン脂肪酸エステル、ポリオキシアルキレンソルビタン脂肪酸エステル、ポリオキシアルキレン脂肪酸アルカノールアミド、ポリオキシアルキレンアルキルグルコシド、ポリオキシアルキレン硬化ひまし油、ポリオキシアルキレンアルキルアミン、ポリオキシアルキレンアルキルフェニルエーテル、等の酸化エチレン縮合型、多価アルコール脂肪酸部分エステル、ポリオキシエチレン多価アルコール脂肪酸部分エステル、ポリオキシエチレン脂肪酸エステル、(ポリ)グリセリン脂肪酸エステル、ポリオキシエチレン硬化ひまし油、ポリオキシエチレンアルキルアミン、トリエタノールアミン脂肪酸部分エステル、アルキルポリグルコシド、プロピレングリコール脂肪酸エステル、ソルビタン脂肪酸エステル、ショ等脂肪酸エステル等の多価アルコールエステル、脂肪酸アルカノールアミド、糖アミンアシル化物、トリエタノールアミン脂肪酸部分エステル、脂肪酸アルキロールアミド、アルキルアミンオキサイド、などのノニオン性界面活性剤;
リン脂質、レシチン、ラノリン、コレステロール、サポニンなどの天然界面活性剤;
ミツロウ、鯨ロウ、ラノリン、カルナバロウ、キャンデリラロウ、綿ロウ、ベイベリーロウ、イボタロウ、モンタンロウ、ヌカロウ、ラノリン、カボックロウ、酢酸ラノリン、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ジョジョバロウ、硬質ラノリン、セラックロウ、ポリオキシエチレンラノリンアルコールエーテル、ポリオキシエチレンラノリンアルコールアセテート、ラノリン脂肪酸ポリエチレングルコール、ポリオキシエチレン水素添加ラノリンアルコールエーテルおよびその誘導体等のロウ;
ラウリルアルコール、セタノール、セトステアリルアルコール、ステアリルアルコール、オレイルアルコール、ベヘニルアルコール、ラノリンアルコール、水添ラノリンアルコール、へキシルデカノール、オクチルドデカノール等の高級アルコール;
コレステロール、フィトステロール等のステロール類;
グリセリン、ジグリセリン、ポリグリセリン、1,3-ブタンジオール、プロパンジオール、ポリエチレングリコールなどのポリオール類;
エチレンジアミン四酢酸およびその塩類、ヒドロキシエチレンジアミン3酢酸およびその塩類、リン酸、アスコルビン酸、コハク酸、グルコン酸、ポリリン酸塩類、メタリン酸塩、ヒノキチール類などの金属イオン封鎖剤;
その他トリクロロルカルバニリド、サリチル酸、ジンクピリチオン、イソプロピルメチルフェノールなどのふけ・かゆみ防止剤;
ベンゾフェノン誘導体、パラアミノ安息香酸誘導体、パラメトキシ桂皮酸誘導体、サリチル酸誘導体その他の紫外線吸収剤;
トウガラシチンキ、ショオウキョウチンキ、カンタリスチンキ、ニコチン酸ベンジルエステルなどの局所刺激剤;
各種ビタミンやアミノ酸などの栄養剤;
女性ホルモン剤;
毛根賦活剤;
酸化亜鉛、硫酸亜鉛、アラントインヒドロキシアルミニウム、塩化アルミニウム、硫酸アルミニウム、スルホ石炭酸亜鉛、タンニン酸、クエン酸、乳酸などの収斂剤;
メントール、カンフルなどの清涼剤;
塩酸ジフェンヒドラミン、マレイン酸クロルフェニラミン、グリチルリチン酸誘導体などの抗ヒスタミン剤;
エストラジオール、エストロン、エチニルエストラジオールなどの皮脂抑制剤;
イオウ、サリチル酸、レゾルシンなどの角質剥離・溶解剤;
グリコール酸、乳酸、リンゴ酸、酒石酸、クエン酸等のα-ヒドロキシ酸;
サリチル酸等のβ-ヒドロキシル酸;
なお、実施例における各種の値は、本発明の実施形態における好ましい下限値又は上限値としてもよいし、上述した本発明の実施形態における同種の値(数値範囲の下限値及び上限値を含む。)と適宜組み合わせて好ましい数値範囲としてもよい。また、実施例における同種の2つの値を適宜組み合わせて好ましい数値範囲としてもよい。
L-グルタミン酸モノナトリウム1水和物104g(0.56mol)、純水265.2g、32%水酸化ナトリウム水溶液69.6g(水酸化ナトリウムとして0.56mol)の混合溶液に、87質量%t-ブタノール水溶液93.2gを加え、この溶液を3℃に維持しつつ、32%水酸化ナトリウムでpHを12に調整しながら塩化ラウロイル117.8g(0.54mol)を攪拌下、滴下した。
この時の有機層中のラウロイルグルタミン酸を主体とする固形分/t-ブタノール/水の成分重量比は、62/24/14であった。
L-グルタミン酸モノナトリウム1水和物104g(0.56mol)、純水145.8g、32%水酸化ナトリウム水溶液69.6g(水酸化ナトリウムとして0.56mol)の混合溶液に、アセトン126gを加え、この溶液を3℃に維持しつつ、32%水酸化ナトリウムでpHを12に調整しながら塩化ラウロイル117.8g(0.54mol)を攪拌下、滴下した。
この時の有機層中のラウロイルグルタミン酸を主体とする固形分/アセトン/水の成分重量比は、55/30/15であった。
L-グルタミン酸モノナトリウム1水和物104g(0.56mol)、純水265.2g、32%水酸化ナトリウム水溶液69.6g(水酸化ナトリウムとして0.56mol)の混合溶液に、87質量%t-ブタノール水溶液93.2gを加え、この溶液を3℃に維持しつつ、32%水酸化ナトリウムでpHを12に調整しながら、塩化ミリストイル26.6g(0.11mol)を撹拌下滴下、続いて塩化ラウロイル94.2g(0.43mol)を攪拌下、滴下した。
この時の有機層中のアシルグルタミン酸(ラウロイルグルタミン酸とミリストイルグルタミン酸)を主体とする固形分/t-ブタノール/水の成分重量比は、62/27/11であった。
下記の成分Bを含む実施例及び比較例において、成分A、成分Bは、下記のHPLCを用いた分析により得られたピークエリア面積から測定をした。
検出器:UV検出器(205nm)
測定機器としては、例えば(株)島津製作所のSPD-10Avp、SPD-10AVvp、SPD-20A及びSPD-20AV等が使用可能である。
分離管:内径6mm、長さ150mmのステンレス管に粒径5μm、孔径12nmのシリカゲルにオクタデシルシリル基を修飾したものを充填した。
分離管温度:60℃付近の一定温度
移動相:メタノール/水/リン酸=2000/400/0.31
流量:毎分0.8mL付近の一定量
成分B比率(%)=[成分Bのピークエリア面積/成分Aのピークエリア面積]×100
上記のようにUV検出を使用すると、アシルPCA(成分B)のピーク感度が他の物質より高いことから、成分B(%)比率においても、高い測定感度を保つことができる。
製造例1で得られたラウロイルグルタミン酸等の固形分/t-ブタノール/水の成分重量比が、62/24/14の有機層100gを、ゆるやかに撹拌しながら液温が90℃に到達するまで常圧にて昇温させた。その後徐々に減圧しながら昇温させ、発泡しすぎないように減圧度をゆるやかに上げていき、到達減圧度20kPaにおいて、到達温度105℃を20分間維持した。その後徐々に常圧に戻し、釜内の溶融物を回収した。得られた固形物を冷蔵庫で一晩置き、ジューサーミキサーにかけて粉砕した結果、56.6gの固形物が得られた。この固形物の乾燥減量は0.25%で、HPLC分析の結果、ラウロイルグルタミン酸94.9%、ラウロイルPCA3.7%、ラウリン酸0.44%であった。他に顕著な不純物は検出されなかった。
製造例1で得られたラウロイルグルタミン酸等の固形分/t-ブタノール/水の成分重量比が62/24/14の有機層100gを、凍結乾燥した。
予備凍結として、棚循環温度を-60℃に設定し、試料温度が-40℃に到達後2時間冷却した。棚循環温度を-40℃に設定し、2時間乾燥後、-10℃に設定し、ほぼ5Paで乾燥した。その後設定温度を、0℃、10℃、30℃に上げた。
品温27.5℃、到達真空度1Pa以下を確認後、乾燥窒素で真空解除した。以上の乾燥工程の所要時間は40時間で実施した。
得られた固形物は、プレート状であり、これをジューサーミキサーにかけて粉砕し、57.1gの固形物が得られた。この固形物の乾燥減量は、1.2%で、HPLC分析の結果、ラウロイルグルタミン酸98.1%、ラウロイルPCAは検出されず、ラウリン酸は0.40%であった。他に顕著な不純物は検出されなかった。
製造例2で得られたラウロイルグルタミン酸等の固形分/アセトン/水の成分重量比が55/30/15の有機層115.0gを、ゆるやかに撹拌しながら液温が50℃に到達するまで常圧にて昇温させる。その後徐々に減圧しながら昇温させ、発泡しすぎないように減圧度をゆるやかに上げていき、到達減圧度が20kPaにて、到達温度105℃に達せさせた。到達減圧度が20kPaにて、到達温度105℃を80分間維持した。その後徐々に常圧に戻し、釜内の溶融物を回収した。濃縮開始後から完了まで10時間を所要した。得られた固形物を冷蔵庫で一晩置き、ジューサーミキサーにかけて粉砕した結果、58.9gの固形物が得られた。この固形物の乾燥減量は0.21%であり、HPLC分析の結果、ラウロイルグルタミン酸83.5%、ラウロイルPCA15.6%、ラウリン酸0.14%であった。他に顕著な不純物は検出されなかった。
製造例2で得られたラウロイルグルタミン酸等の固形分/アセトン/水の成分重量比が55/30/15の有機層115.0gを、凍結乾燥した。
予備凍結として、棚循環温度を-60℃に設定し、試料温度が-40℃に到達後2時間冷却した。棚循環温度を-40℃に設定し、2時間乾燥後、-10℃に設定し、ほぼ12Paで乾燥した。その後設定温度を、0℃、15℃、30℃に上げた。
品温27.5℃、到達真空度1Pa以下を確認後、乾燥窒素で真空解除した。以上の乾燥工程の所要時間は70時間で実施した。
得られた固形物は、プレート状であり、これをジューサーミキサーにかけて粉砕し、59.5gの固形物が得られた。この固形物の乾燥減量は0.51%であり、HPLC分析の結果、ラウロイルグルタミン酸98.9%、ラウロイルPCAとラウリン酸は検出されなかった。他に顕著な不純物は検出されなかった。
製造例3で得られたアシルグルタミン酸等の固形分/t-ブタノール/水の成分重量比が、62/27/11の有機層100.0gを、ゆるやかに撹拌しながら液温が70℃に到達するまで常圧にて昇温させる。その後徐々に減圧しながら昇温させ、発泡しすぎないように減圧度をゆるやかに上げていき、到達減圧度が20kPaにて、到達温度115℃に達せさせ、これを20分間維持した。その後徐々に常圧に戻し、釜内の溶融物を回収した。得られた固形物を冷蔵庫で一晩置き、ジューサーミキサーにかけて粉砕した結果、55.5gの固形物が得られた。この固形物の乾燥減量は0.14%であり、HPLC分析の結果、アシルグルタミン酸90.9%、アシルPCA7.7%、遊離脂肪酸(ラウリン酸とミリスチン酸総計)は0.74%であった。他に顕著な不純物は検出されなかった。
製造例3で得られたアシルルグルタミン酸等の固形分/t-ブタノール/水の成分重量比が62/27/11の有機層100gを、凍結乾燥した。
予備凍結として、棚循環温度を-60℃に設定し、試料温度が-40℃に到達後2時間冷却した。棚循環温度を-40℃に設定し、2時間乾燥後、-10℃に設定し、ほぼ5Paで乾燥した。その後設定温度を、0℃、20℃、30℃に上げた。
品温27.5℃、到達真空度1Pa以下を確認後、乾燥窒素で真空解除した。以上の乾燥工程の所要時間は55時間で実施した。
得られた固形物は、プレート状であり、これをジューサーミキサーにかけて粉砕し、57.2gの固形物が得られた。この固形物の乾燥減量は、0.61%で、HPLC分析の結果、アシルグルタミン酸98.6%、アシルPCAは検出されず、遊離脂肪酸は0.54%であった。他に顕著な不純物は検出されなかった。
製造例1と同等の操作を別途再度実施して、ラウロイルグルタミン酸等の固形分/t-ブタノール/水の成分重量比が、64/25/11の有機層を得た。この有機層125gをゆるやかに撹拌しながら液温が90℃に到達するまで常圧にて昇温させた。その後徐々に減圧しながら昇温させ、発泡しすぎないように減圧度をゆるやかに上げていき、到達減圧度40kPaにおいて、到達温度105℃を120分間維持した。その後徐々に常圧に戻し、釜内の溶融物を回収した。得られた固形物を冷蔵庫で一晩置き、ジューサーミキサーにかけて粉砕した結果、70.6gの固形物が得られた。この固形物の乾燥減量は0.20%で、HPLC分析の結果、ラウロイルグルタミン酸80.7%、ラウロイルPCA14.1%、ラウリン酸4.7%であった。他に顕著な不純物は検出されなかった。
成分Aに対する成分C及び成分Dの比率を算出する際は、下記のHPLCを用いた分析により得られたピークエリア面積から純度を算出した。
検出器:RI検出器
分離管:内径6mm、長さ150mmのステンレス管に、粒径5μm、孔径12nmのシリカゲルにオクタデシルシリル基を修飾したものを充填した。
分離管温度:60℃付近の一定温度
移動相:メタノール/水/リン酸=2000/400/0.31
流量:毎分0.8mL
続いて、成分C/成分A+C、成分D/成分A+Dは下記式で示され、下記表中の「成分C質量(%)」、「成分D質量(%)」に該当する。
成分C/成分A+C=
[成分Cの純分(g)/成分A純分(g)+成分C純分(g)]×100(%)
成分D/成分A+D=
[成分Dの純分(g)/成分A純分(g)+成分D純分(g)]×100(%)
旭化成ファインケム(株)製ペリセアL-30の凍結乾燥物(水分2.0%)もしくは、実施例1で酸クロライドを変更して製造したその凍結乾燥物を原料として、下記の操作を実施した。上記凍結乾燥物と蒸留水とターシャリーブタノールを重量比45/33/22で60℃にて撹拌する。60℃到達後、硫酸をゆるやかに添加し、65℃でpH2になるまで硫酸添加を続け、30分後に撹拌を停止し、静置する。30分静置後、分層した下層(水層)を除いた。下層(水層)を秤量し、同重量の20重量%ターシャリーブタノール水溶液(ターシャリーブタノール/蒸留水の重量比が2/8)を上層に加え、60℃にて撹拌する。30分後に撹拌を止め、30分間静置する。下層をまた除く。前述の下層と同重量の20重量%ターシャリーブタノール水溶液を注入してから、撹拌、静置、下層を除く工程(水洗脱塩工程)を、さらに2回、計3回繰り返した。水洗脱塩工程を終えた有機層を凍結乾燥した。
窒素雰囲気10℃の条件下で、ピログルタミン酸90mmol、トリエチルアミン180mmol、アセトニトリル150mLをフラスコ内で撹拌混合した。次に、アセトニトリル60mLに各種酸クロライド90mmolを加えた溶液を添加後、氷浴から取り出し反応混合物を室温で2時間撹拌した。反応混合物をガラスフィルターで濾過した後、減圧下でエバポレーターを用いて濃縮した。水150 mLと1 M塩酸120 mLを加えた後、残渣を酢酸エチル100 mLで4回抽出した。併合した有機層を硫酸マグネシウムで乾燥させた後、真空で濃縮した。残渣をヘプタン/酢酸エチル=5:4(90mL)で再結晶し、アシルピログルタミン酸を純度95%以上で得た。
旭化成ファインケム(株)製アミノサーファクトALMS-P1もしくは、酸クロライドを変更して製造例1と同様の方法で製造した組成物に水洗操作を2度くり返した後、得られた有機層から溶媒を除去し、水酸化ナトリウムで固形分30質量%、pH7(25℃)の水溶液になるように中和調製乾燥させた組成物を原料として、下記の操作を実施した。上記製品と蒸留水とターシャリーブタノールを重量比45/33/22で60℃にて撹拌する。60℃到達後、硫酸をゆるやかに添加し、65℃でpH2になるまで硫酸添加を続け、30分後に撹拌を停止し、静置する。30分静置後、分層した下層(水層)を除いた。下層(水層)を秤量し、同重量の20重量%ターシャリーブタノール水溶液(ターシャリーグタノール/蒸留水の重量比が2/8)を上層に加え、60℃にて撹拌する。30分後に撹拌を止め、30分間静置する。下層をまた除く。前述の下層と同重量の20重量%ターシャリーブタノール水溶液を注入してから、撹拌、静置、下層を除く工程(水洗脱塩工程)を、さらに2回、計3回繰り返した。水洗脱塩工程を終えた有機層を凍結乾燥した。
東京化成工業(株)より、カプリル酸(O0027)、ラウリン酸(L0011)、ミリスチン酸(M0476)、パルミチン酸(P1145)、ステアリン酸(S0163)、ベヘン酸(B1248)を入手した。
富士フイルム和光純薬(株)より、カプリル酸アミド(O237203)、ラウリン酸アミド(516472)、ミリスチン酸アミド(B22610)、パルミチン酸アミド(QE-1627)、ステアリン酸アミド(192-04015)、ベヘン酸アミド(B131150)を入手した。
実施例及び比較例において、成分Eは、下記のLC-MSを用いた分析により純度を確認した。
(LC-MS装置)
分離管:内径2mm、長さ30mmのステンレス管に、粒径3μmの粒子にフェニル基を修飾したものを充填した。
分離管温度:40℃付近の一定温度
移動相:10mM酢酸アンモニウム水溶液及びアセトニトリルのグラジエント溶出法
流量:毎分0.3mL付近の一定量
測定機器としては、例えば(株)島津製作所のLCMS-9030等が使用可能である。
イオン化:ESI+
スキャンレンジ:m/z50~1200
M+H:200.203
実施例及び比較例において、成分Eと成分Aの比率を算出する際は、下記のHPLCを用いた分析により純度を確認した。
検出器:UV検出器(205nm)
測定機器としては、例えば(株)島津製作所のSPD-10Avp、SPD-10AVvp、SPD-20A及びSPD-20AV等が使用可能である。
分離管:内径6mm、長さ150mmのステンレス管に、粒径5μm、孔径12nmのシリカゲルにオクタデシルシリル基を修飾したものを充填した。
分離管温度:60℃付近の一定温度
移動相:メタノール/水/リン酸=2000/400/0.31
流量:毎分0.8mL付近の一定量
より具体的には、成分E/成分Aは下記式で示し、下記表中の「成分E質量(%)」に該当する。
成分E/成分A=[成分Eの純分(g)/成分A純分(g)]×100(%)
下記の組成を作製した。
組成 wt%
・実施例又は比較例の32%水溶液 0.09
・油(パルミチン酸エチルヘキシル、オリーブオイル
ミネラルオイル、シクロメチコン、ジメチコン) 20.0
・カルボマー(カーボポール981) 0.2
・30wt/v% NaOH水溶液 0.28
・精製水 79.43
1.カルボマーを精製水に溶解させる。
2.カルボマー水溶液をKOHもしくはトリエタノールアミンもしくはアルギニンもしくはNaOH水溶液で指定のpHに調整する。
3.実施例又は比較例の32%水溶液と、それぞれの油を加える。
4.室温で5分間、ホモミキサー(6000rpm)を用いて乳化する。
評価基準
5:液深の全部にわたり乳化している
4:液深の90%以上が乳化している
3:液深の80%以上が乳化している
2:液深の70%以上が乳化している
1:乳化している液深が70%に満たない
下記の組成を作製した。
組成 wt%
・実施例又は比較例の32%水溶液 0.09
・ミネラルオイル(5,8~8.9mm2/s) 16.0
・固形油(セトステアリルアルコール、ミリスチルアルコール) 4.0
・カルボマー(カーボポール981) 0.2
・30wt/v% NaOH水溶液 0.28
・精製水 79.43
1.カルボマーを精製水に溶解させ、カルボマー水溶液をKOHもしくはトリエタノールアミンもしくはアルギニンもしくはNaOH水溶液で指定のpHに調整する。
2.実施例又は比較例の32%水溶液と精製水を加えて水相とする。これを70℃まで加温する。
3.ミネラルオイルと固形油を油相として、70℃まで加温する。
4.水相と油相を混合し、ホモミキサー3000rpmで80℃まで撹拌昇温する。
5.ホモミキサー6000rpmで5分間乳化を実施する。
6.ホモミキサー3000rpmで25℃まで撹拌、冷却する。
7.脱気を行う。
評価基準
5:液深の全部にわたり乳化している。
4:液深の90%以上が乳化している。
3:液深の80%以上が乳化している。
2:液深の70%以上が乳化している。
1:乳化している液深が70%に満たない液深
実施例、比較例それぞれの固形分0.0075%水溶液に、1%濃度となるように酸化チタンを添加して、指定のpHになるようにKOHもしくはトリエタノールアミンもしくはアルギニンもしくはNaOH水溶液を添加した。その後、超音波処理を30秒間実施し、ホモジナイズ(10000rpm、2分)後、50℃で静置した時の上澄み液の吸光度(波長300nm)を測定し、水中分散性を確認した。
いずれの吸光度初期値も、1.8付近であり、200時間後、224時間後248時間後の吸光度測定で下記の評価を実施した。
評価基準
5:吸光度が1.7以上である
4:吸光度が1.5以上で1.7未満
3:吸光度が1.3以上で1.5未満
2:吸光度が1.0以上で1.3未満
1:吸光度が1.0未満
乳化安定性確認試験1で調製したジメチコンの処方について下記の通り評価した。5名のパネラーによって官能評価を行い、平均値を評価点とした。
非常にみずみずしさがある 5
みずみずしさがある 4
僅かにみずみずしさがある 3
ほとんどみずみずしさがない 2
みずみずしさがない 1
べたつきがない 5
ほとんどべたつかない 4
僅かにべたつく 3
べたつく 2
とてもべたつく 1
非常にコク感がある 5
コク感がある 4
僅かにコク感がある 3
ほとんどコク感がない 2
コク感がない 1
非常に伸びが良い 5
伸びが良い 4
僅かに伸びが良い 3
あまり伸びがよくない 2
伸びが良くない 1
非常に滑らかさがある 5
滑らかさがある 4
僅かに滑らかさがある 3
あまり滑らかさがない 2
滑らかさがない 1
なお、上述のとおり、表中の「成分B比率(%)」は成分Aに対するもの、「成分C質量(%)」は成分Aと成分Cの合計に対するもの、「成分D質量(%)」は成分Aと成分Dの合計に対するもの、「成分E質量(%)」は成分Aに対するもの、である。
Claims (16)
- 下記成分Aと、
下記成分B、下記成分C、下記成分D及び下記成分Eからなる群から選択される1種以上の成分(ただし、前記成分Cのみ、又は前記成分Dのみは除く)と、
を含有することを特徴とする組成物
・成分A:下記一般式(A)で表されるアシル基含有アミノ酸誘導体又はその塩
R1及びR2は、各々独立に、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M1、M2、及びM3は、各々独立に、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛であり、
n1及びn2は、0及び2であるか、又は2及び0であり、
n3及びn4は、0及び2であるか、又は2及び0である)
・成分B:下記一般式(B)で表されるN-アシルピロリドンカルボン酸又はその塩
R3は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M4は、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛である)
・成分C:下記一般式(C)で表されるアシルグルタミン酸又はその塩
R4は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M5及びM6は、各々独立に、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛である)
・成分D:下記一般式(D)で表される脂肪酸又はその塩
R5は、飽和又は不飽和の直鎖又は分枝状の炭化水素基であり、
M7は、水素原子、アルカリ金属、アルカリ土類金属、有機若しくは無機アミン、塩基性アミノ酸、コリン、アルミニウム、又は亜鉛である)
・成分E:下記一般式(E)で表される脂肪酸アミド
R6は、飽和又は不飽和の直鎖又は分枝状の炭化水素基である)。 - 前記成分Aと、前記成分Bとを含有する、請求項1に記載の組成物。
- 前記成分Aと、前記成分Eとを含有する、請求項1に記載の組成物。
- 前記成分Aと、前記成分Bと、前記成分Eとを含有する、請求項1に記載の組成物。
- 前記一般式(A)~(E)におけるR1~R6が、各々独立に、炭化数1~29の炭化水素基である、請求項1~4のいずれかに記載の組成物。
- 前記一般式(A)~(D)におけるM1~M7が、各々独立に、Na、K、トリエタノールアミン、Mg、Ca、Al、Zn、アルギニン、又はHである、請求項1~5のいずれかに記載の組成物。
- 前記成分Bの、前記成分Aに対する割合が、0.004%以上である、請求項1、2、4、5及び6のいずれかに記載の組成物。
- 前記成分Cの量が、前記成分Aと前記成分Cとの合計質量を基準として、0.8質量%以上であり、
前記成分Dの量が、前記成分Aと前記成分Dとの合計質量を基準として、0.06質量%以上である、
請求項1及び5~7のいずれかに記載の組成物。 - 前記成分Eの量が、、前記成分Aの質量を基準として、0.005質量%以上である、請求項1及び3~8のいずれかに記載の組成物。
- 以下の工程を含む、請求項1、2及び4~9のいずれかに記載の組成物の製造方法:
1)水と有機溶媒とを含む混合溶媒中で、グルタミン酸又はその塩と脂肪酸クロライドとを反応させて、N-アシルグルタミン酸又はその塩を含む反応液を得、前記反応液を酸でpH1~6とし、25~80℃の温度において有機層と水層とに分層する工程;
2)前記有機層を酸性下で濃縮乾燥し、前記N-アシルグルタミン酸又はその塩の一部をN-アシルピロリドンカルボン酸又はその塩に変換する工程;
3)前記N-アシルグルタミン酸又はその塩と酸無水物とを反応させて、N-アシルグルタミン酸無水物を得る工程;及び
4)前記N-アシルグルタミン酸無水物とリジン又はその塩とを反応させて、アシル基含有アミノ酸誘導体又はその塩を得る工程。 - 前記工程2)において、前記有機相を、乾燥減量が10質量%以下になるまで濃縮乾燥する、請求項10に記載の製造方法。
- 前記工程2)における濃縮乾燥を減圧下にて、50℃以上で実施する、請求項10又は11に記載の製造方法。
- 香粧品原料組成物である、請求項1~9のいずれかに記載の組成物。
- 請求項1~9のいずれかに記載の組成物の香粧品原料としての使用。
- 請求項1~9のいずれかに記載の組成物を配合した化粧料。
- pH4以上である、請求項15に記載の化粧料。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020237014158A KR20230072504A (ko) | 2020-11-02 | 2021-10-28 | 조성물 및 그의 제조 방법 그리고 화장료 |
JP2022559246A JPWO2022092232A1 (ja) | 2020-11-02 | 2021-10-28 | |
EP21886349.6A EP4239037A1 (en) | 2020-11-02 | 2021-10-28 | Composition, method for producing same, and cosmetic |
US18/034,919 US20230414481A1 (en) | 2020-11-02 | 2021-10-28 | Composition and Method for Producing Same and Cosmetic Agent |
CN202180073280.7A CN116507696A (zh) | 2020-11-02 | 2021-10-28 | 组合物及其制造方法以及化妆品 |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020-183653 | 2020-11-02 | ||
JP2020183653 | 2020-11-02 | ||
JP2021005540 | 2021-01-18 | ||
JP2021-005540 | 2021-01-18 | ||
JP2021-042818 | 2021-03-16 | ||
JP2021042818 | 2021-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022092232A1 true WO2022092232A1 (ja) | 2022-05-05 |
Family
ID=81383400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2021/039903 WO2022092232A1 (ja) | 2020-11-02 | 2021-10-28 | 組成物及びその製造方法並びに化粧料 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230414481A1 (ja) |
EP (1) | EP4239037A1 (ja) |
JP (1) | JPWO2022092232A1 (ja) |
KR (1) | KR20230072504A (ja) |
TW (1) | TWI809547B (ja) |
WO (1) | WO2022092232A1 (ja) |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006160686A (ja) | 2004-12-09 | 2006-06-22 | Asahi Kasei Chemicals Corp | 防腐効果の高い化粧料 |
JP4070768B2 (ja) | 2002-08-27 | 2008-04-02 | 旭化成ケミカルズ株式会社 | 新規アシル基含有組成物 |
JP2010105964A (ja) * | 2008-10-30 | 2010-05-13 | Aderans Co Ltd | パーマネント及びヘアカラー用後処理剤 |
JP2011039229A (ja) * | 2009-08-10 | 2011-02-24 | Fuji Xerox Co Ltd | 静電荷像現像用結着樹脂、静電荷像現像用トナー、静電荷像現像用トナーの製造方法、静電荷像現像用現像剤、トナーカートリッジ、プロセスカートリッジ、画像形成方法および画像形成装置 |
JP2016053093A (ja) * | 2009-12-16 | 2016-04-14 | ロレアル | 化粧品の処方のためのキット |
JP2018043971A (ja) * | 2016-09-09 | 2018-03-22 | 文稔 大城 | 化粧料 |
JP2019099536A (ja) * | 2017-12-07 | 2019-06-24 | 正子 登坂 | 外用組成物、皮膚外用剤、および、毛髪育養キット |
JP2020121935A (ja) * | 2019-01-29 | 2020-08-13 | 株式会社 資生堂 | 白濁化粧料 |
JP2020125374A (ja) * | 2019-02-01 | 2020-08-20 | 高級アルコール工業株式会社 | 乳化組成物および複合体 |
JP2020164448A (ja) * | 2019-03-29 | 2020-10-08 | 株式会社コーセー | 油性化粧料 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106999360B (zh) * | 2014-12-16 | 2021-03-12 | 株式会社高丝 | 水包油型乳液组合物 |
-
2021
- 2021-10-28 JP JP2022559246A patent/JPWO2022092232A1/ja active Pending
- 2021-10-28 EP EP21886349.6A patent/EP4239037A1/en active Pending
- 2021-10-28 KR KR1020237014158A patent/KR20230072504A/ko active Search and Examination
- 2021-10-28 WO PCT/JP2021/039903 patent/WO2022092232A1/ja active Application Filing
- 2021-10-28 US US18/034,919 patent/US20230414481A1/en active Pending
- 2021-11-02 TW TW110140722A patent/TWI809547B/zh active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4070768B2 (ja) | 2002-08-27 | 2008-04-02 | 旭化成ケミカルズ株式会社 | 新規アシル基含有組成物 |
JP2006160686A (ja) | 2004-12-09 | 2006-06-22 | Asahi Kasei Chemicals Corp | 防腐効果の高い化粧料 |
JP2010105964A (ja) * | 2008-10-30 | 2010-05-13 | Aderans Co Ltd | パーマネント及びヘアカラー用後処理剤 |
JP2011039229A (ja) * | 2009-08-10 | 2011-02-24 | Fuji Xerox Co Ltd | 静電荷像現像用結着樹脂、静電荷像現像用トナー、静電荷像現像用トナーの製造方法、静電荷像現像用現像剤、トナーカートリッジ、プロセスカートリッジ、画像形成方法および画像形成装置 |
JP2016053093A (ja) * | 2009-12-16 | 2016-04-14 | ロレアル | 化粧品の処方のためのキット |
JP2018043971A (ja) * | 2016-09-09 | 2018-03-22 | 文稔 大城 | 化粧料 |
JP2019099536A (ja) * | 2017-12-07 | 2019-06-24 | 正子 登坂 | 外用組成物、皮膚外用剤、および、毛髪育養キット |
JP2020121935A (ja) * | 2019-01-29 | 2020-08-13 | 株式会社 資生堂 | 白濁化粧料 |
JP2020125374A (ja) * | 2019-02-01 | 2020-08-20 | 高級アルコール工業株式会社 | 乳化組成物および複合体 |
JP2020164448A (ja) * | 2019-03-29 | 2020-10-08 | 株式会社コーセー | 油性化粧料 |
Also Published As
Publication number | Publication date |
---|---|
TWI809547B (zh) | 2023-07-21 |
EP4239037A1 (en) | 2023-09-06 |
KR20230072504A (ko) | 2023-05-24 |
JPWO2022092232A1 (ja) | 2022-05-05 |
US20230414481A1 (en) | 2023-12-28 |
TW202228640A (zh) | 2022-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4331584B2 (ja) | 油性基剤及びこれを含有する化粧料及び皮膚外用剤 | |
JP4815166B2 (ja) | 油性基剤及びこれを含有する化粧料及び皮膚外用剤 | |
JP2003226609A (ja) | ラノリン類似組成物並びにこれを含有する化粧料及び皮膚外用剤 | |
JP4573383B2 (ja) | 化粧用油剤及びこれを用いた化粧料及び外用剤 | |
JP2001031580A (ja) | 皮膚外用剤 | |
JP3525233B2 (ja) | 化粧料 | |
JP2005306867A (ja) | イノシトール誘導体を含有する皮膚外用剤及び化粧料 | |
JP3623548B2 (ja) | 化粧料 | |
JP2006225373A (ja) | エマルジョン | |
JP2014073971A (ja) | エマルジョン、組成物、香粧品組成物、及び医薬品組成物 | |
WO2022092232A1 (ja) | 組成物及びその製造方法並びに化粧料 | |
JP6472038B2 (ja) | 化粧料用油剤及びそれを配合する化粧料 | |
JPH0764704B2 (ja) | 化粧料 | |
JP3472260B2 (ja) | 洗浄料 | |
JP2000344697A (ja) | 長鎖分岐アルコール及びこれを用いた化粧料及び外用剤 | |
JP3784723B2 (ja) | 外用剤 | |
JP2003238447A (ja) | 外用剤 | |
JP2002068930A (ja) | 油性化粧料 | |
CN116507696A (zh) | 组合物及其制造方法以及化妆品 | |
JP4625595B2 (ja) | 皮膚洗浄料 | |
JP2013023488A (ja) | 化粧料用油剤及びそれを配合する化粧料 | |
JP4834236B2 (ja) | シリコーン誘導体及びこれを含有する油剤、化粧料及び外用剤 | |
JP3457634B2 (ja) | 化粧料 | |
JP3529729B2 (ja) | 可溶化型化粧料 | |
JP4431291B2 (ja) | 皮膚化粧料 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 21886349 Country of ref document: EP Kind code of ref document: A1 |
|
DPE2 | Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101) | ||
ENP | Entry into the national phase |
Ref document number: 20237014158 Country of ref document: KR Kind code of ref document: A Ref document number: 2022559246 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 202180073280.7 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 18034919 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2021886349 Country of ref document: EP Effective date: 20230602 |