WO2022015055A1 - Composition pour prévenir la chute des cheveux et stimuler la pousse des cheveux - Google Patents

Composition pour prévenir la chute des cheveux et stimuler la pousse des cheveux Download PDF

Info

Publication number
WO2022015055A1
WO2022015055A1 PCT/KR2021/009057 KR2021009057W WO2022015055A1 WO 2022015055 A1 WO2022015055 A1 WO 2022015055A1 KR 2021009057 W KR2021009057 W KR 2021009057W WO 2022015055 A1 WO2022015055 A1 WO 2022015055A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
hair
promoting
hair growth
hair loss
Prior art date
Application number
PCT/KR2021/009057
Other languages
English (en)
Korean (ko)
Inventor
신재영
김재윤
최윤호
이상화
강형미
Original Assignee
주식회사 엘지생활건강
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 엘지생활건강 filed Critical 주식회사 엘지생활건강
Priority to CN202180060665.XA priority Critical patent/CN116209425A/zh
Priority to JP2023503031A priority patent/JP2023534287A/ja
Publication of WO2022015055A1 publication Critical patent/WO2022015055A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a composition for preventing hair loss and promoting hair growth.
  • hair occupies an important part. Hair is a thin, keratinized structure produced on the surface of the skin. In addition to the role of cushion against external shock, it protects the human body from external stimuli such as direct sunlight, cold, friction, and danger, and discharges heavy metals such as arsenic, mercury and zinc that are harmful to the body. Aspects are also highlighted.
  • external stimuli such as direct sunlight, cold, friction, and danger
  • heavy metals such as arsenic, mercury and zinc that are harmful to the body. Aspects are also highlighted.
  • an increasing number of people complain of hair loss due to various causes, including changes in diet and increased internal and external stress. It is known that genetic factors act as the main cause of hair loss, but as mentioned above, increase in social stress, environmental pollution, frequent perms and dyeing, and incorrect scalp care are also emerging as causes of hair loss.
  • placode Human hair has about 100,000 to 150,000 hairs, and each hair has a different growth cycle.
  • placode is formed by basal epidermal cells by the action of beta-catenin (Sarah E. Miller, 2002).
  • Dermal fibroblasts receiving a signal from the formed placode form a dermal condensate.
  • the placode grows and infiltrates in the dermis direction and merges with the skin condensate to form a primary hair germ.
  • the epidermal cells that form the hair embryo grow long in the direction of the dermis, and form a hair peg, a long columnar structure made of multiple layers, while the skin condensate is formed into a spherical dermal papilla. do.
  • the tip of the hair peg becomes thicker to form a hair bulb, which wraps around the dermal papilla to complete the hair follicle, and the epidermal cells inside the hair follicle differentiate to produce hair.
  • the first generated hair goes through a growth phase, a degeneration phase, and a resting phase, and then goes through a cycle of falling out and entering the growth phase again.
  • the hair growth cycle consists of three phases: the anagen stage, in which hair is most actively grown, the catagen stage, in which hair degeneration begins, and the telogen stage, in which hair growth stops or enters rest. ) is classified as
  • outer root sheath cells including dermal papilla cells and hair follicle stem cells constituting hair follicles, and various cytokines and growth factors produced in these cells play an important role is known to do
  • DKK-1 Dickkopf-1
  • stem cells which is known to be accomplished by the generation and activation of Wnt/ ⁇ -catenin.
  • growth factors such as VEGF, IGF-1, and FGF are known to promote the growth phase of hair
  • TGFb-1 and EGF are known as growth factors that induce the degenerative phase of hair follicles.
  • alopecia refers to an increase in the number of abnormal hair loss due to a shorter hair growth phase and more hair in a degenerative or resting phase among these cycles.
  • Hair loss is a normal phenomenon, but a normal person has a lot of hair in a growth phase, whereas a person with normal alopecia has a lot of hair in a telogen state, so visible hair loss is shown.
  • a characteristic of people with alopecia is the miniaturization of their hair. As hair loss progresses, the growth period becomes shorter and the transition to the catagen and resting phases is accelerated, and the volume of the dermal papilla that follows becomes smaller and the hair follicles become smaller. Therefore, for the treatment of hair loss, it is important to allow the hair follicles in the resting state to quickly transition to the growth phase and to extend the shortened growth phase.
  • the causes of hair loss include male hormone action, excessive sebum secretion, poor blood circulation, decreased scalp function due to peroxide or bacteria, genetic factors, aging, and stress have been discussed.
  • the clear cause of hair loss has not been elucidated, and it is known that very complex actions are intertwined.
  • the currently known hair loss prevention products have active ingredients that promote blood circulation, strengthen hair root function, moisturize the scalp, prevent dandruff, have an antioxidant effect, extend the hair growth phase, and suppress the action of male hormones.
  • the target ingredient is included, there is still no one with a clear effect in terms of effect, and the problem of side effects is raised.
  • adenosine is a component of amino acids made in cells and is a main component of cellular energy metabolism.
  • Adenosine is one of the constituent elements of DNA, which is a gene, and is a compound in which a base called adenine and a sugar called ribose are combined.
  • Adenosine becomes ATP (adenosine 5'-triphosphate), which is the main source of intracellular energy when three phosphates are combined with sugar.
  • ATP adenosine 5'-triphosphate
  • adenosine is known as an important factor that plays a decisive role in all metabolism smoothly proceeding while composing the body. Because adenosine is an intracellular component, it has excellent stability and durability when penetrating into the skin, and has a synergistic effect on skin wrinkles by promoting DNA and protein synthesis in the dermal layer.
  • niacinamide is a kind of vitamin B complex, coexisting with nicotinic acid and widely distributed in the plant world, and exists as a component of the redox coenzyme NAD or NADP in the living body of the animal system.
  • Niacinamide is a bioactive amide of vitamin B3, also known as pyridine-3-carboxylic acid, which is also known to act as an anti-inflammatory raw material or antioxidant.
  • Niacinamide inhibits the movement of melanosomes, thereby inhibiting the movement of synthesized melanin to keratinocytes, thereby reducing skin pigmentation and enhancing whitening action.
  • niacinamide increases the synthesis of collagen and intercellular lipids, thereby having an advantageous effect on skin moisturizing and the like.
  • D-panthenol (dexpanthenol) can be called provitamin B5 in the alcohol form of vitamin B5 (Pantothenic acid). D-panthenol is absorbed into the skin and converted directly to vitamin B5 for use. D-panthenol is a component of a skin moisturizer and wrinkle improvement agent, and is widely used in cosmetics and household products, and is also used as an ointment for wound healing, skin burns, and itchiness improvement. In addition, D-panthenol is known as a permeable moisturizer, and it is known for its effects of conditioning the skin and hair and increasing the recovery of damaged hair.
  • succulents are perennial herbaceous medicinal plants belonging to the family Knobaceae, and their scientific names are Pleuropterus multiflorus , Polygonum multiflorum , Fagopyrum multiflorum , Reynoutria multiflora , or Fallopia multiflora .
  • Sauerkraut extract is used as a tonic, stimulant, analgesic, antihypertensive, or antitussive, and is known to be used to treat colds, hematemesis, nervous breakdown, or arthritis.
  • Eoseongcho Houttuynia cordata
  • Yakmomil Chinese medicinal herb, Jueupchae or Sipyak as a perennial plant of the family Trifolium .
  • Eoseongcho is called eoseongcho because it contains various essential oils and gives off a unique smell like fishy smell.
  • Eoseongcho blooms mainly from May to July, and is a medicinal herb used in folk medicine for gonorrhea, enteritis, urinary tract infection, pneumonia, or bronchitis.
  • zinc pyrithione has an antibacterial action, preventing the growth of microorganisms on the scalp and skin.
  • zinc pyrithione has a proliferation inhibitory effect on malassezia and other fungi, and serves to prevent seborrheic dermatitis and dandruff on the scalp.
  • salicylic acid is the main component of aspirin and has been widely used as an anti-inflammatory, analgesic or antipyretic agent.
  • Salicylic acid exfoliates and softens the skin.
  • Salicylic acid is mainly added to cosmetics such as cleansing foams to soften and exfoliate dead skin cells to soften pores. Through this, salicylic acid can help discharge sebum in the pores and keep the skin clean.
  • salicylic acid exhibits antibacterial and anti-inflammatory action, thereby inhibiting the growth of the scalp or skin microorganisms, thereby improving the skin and scalp or preventing dandruff.
  • minoxidil (2,4-diamino-6-piperidinopyrimidine-3-oxide) is the only hair loss treatment approved by the US Food and Drug Administration (FDA) at present, but when used for 32 to 48 weeks, the effect is 38% each. and 13%, which is unsatisfactory, and has a disadvantage in that the effect is inferior to the bangs.
  • FDA US Food and Drug Administration
  • the problem to be solved by the present disclosure is to provide a composition for preventing hair loss or promoting hair growth having an excellent hair loss prevention and/or hair growth promoting effect.
  • the problem to be solved by the present disclosure is to provide a product for hair or scalp comprising the composition for preventing hair loss or promoting hair growth.
  • the present inventors improve the problems such as side effects and precautions for use of conventional hair loss treatment agents, and without disadvantages such as weak hair growth promoting effect of hair loss prevention / hair growth agent, it is safe for the human body and can effectively act in preventing hair loss and promoting hair growth Efforts were made to develop a composition that has As a result, the present inventors have found that when a specific active ingredient is further combined with a mixture of adenosine, D-panthenol and niacinamide, a remarkable synergistic effect occurs in preventing hair loss and promoting hair growth.
  • the present inventors added any one or more selected from the group consisting of adenosine, D-panthenol and niacinamide to a mixture of adenosine, D-panthenol and niacinamide through an in-vitro experiment
  • adenosine, D-panthenol and niacinamide to a mixture of adenosine, D-panthenol and niacinamide through an in-vitro experiment
  • the present inventors confirmed that, when treating alopecia patients with a composition for preventing hair loss or promoting hair growth comprising the above combination, the number of hairs per unit area and average hair thickness were remarkably improved to have a remarkably excellent effect in the treatment of alopecia (Experimental Examples 4 and 5).
  • the present disclosure relates to a mixture of adenosine, D-panthenol and niacinamide; And it provides a composition for preventing hair loss or promoting hair growth, comprising as an active ingredient any one or more selected from the group consisting of sauerkraut extract, eosincho extract, zinc pyrithione and salicylic acid.
  • the present disclosure provides a mixture of adenosine, D-panthenol and niacinamide; Sauerkraut extract, Eosinosaurus extract, or both; and zinc pyrithione, salicylic acid, or both as an active ingredient. It provides a composition for preventing hair loss or promoting hair growth.
  • the composition for preventing hair loss or promoting hair growth has a remarkable synergistic effect in preventing hair loss or promoting hair growth by the combination between the active ingredients.
  • the sewage extract or Eoseongcho extract may be extracted by a method known in the art, the method is not particularly limited, or a commercially available extract may be used.
  • the sewage extract or eoseongcho extract may be an extract obtained by extracting sewage or eoseongcho with water and/or an organic solvent, and the organic solvent may be a polar organic solvent, a non-polar organic solvent, or a mixed solvent thereof.
  • the polar organic solvent may be a lower alcohol having 1 to 5 carbon atoms, ethyl acetate or acetone
  • the non-polar organic solvent may be ether, chloroform, benzene, nucleic acid or dichloromethane.
  • the lower alcohol having 1 to 5 carbon atoms may be methanol, ethanol, propanol, butanol or isopropanol.
  • the sewage extract or Eoseongcho extract may include a fraction obtained by fractionating the primary extract extracted using the above-described extraction solvent using an extraction solvent having a different polarity.
  • the sewage extract or eosincho extract may be a fraction obtained by extracting with an alcohol having 1 to 5 carbon atoms, and then re-fractioning with a solvent having a different polarity, such as ether, benzene, or hexane.
  • a solvent having a different polarity such as ether, benzene, or hexane.
  • two or more solvents may be used, and each solvent extract may be prepared by sequentially using or mixing them according to the polarity of the solvent.
  • the solvent may be removed by filtering or performing a concentration or drying process on the prepared extract or the fraction obtained by performing the fractionation process, and all of the filtration, concentration and drying may be performed.
  • the filtration may be performed using filter paper or a reduced pressure filter, and the concentration may be concentrated under reduced pressure using a reduced pressure concentrator or the like, and drying may be performed by a freeze-drying method.
  • further purified fractions can be obtained by purifying the prepared extract or the fraction obtained by performing the fractionation process using various chromatography methods such as silica gel column chromatography, thin layer chromatography, or high performance liquid chromatography. .
  • a mixture of adenosine, D-panthenol and niacinamide included in the composition for preventing hair loss or promoting hair growth of the present disclosure is 0.0001 to 10% by weight, preferably 0.001 to 7% by weight, more preferably from the total weight of the composition. It may be 0.01 to 5% by weight.
  • the effect of promoting hair growth is insignificant, and when it exceeds 10% by weight, the stability of the formulation is deteriorated, which is not preferable.
  • the effect of preventing hair loss and promoting hair growth was remarkably excellent when the active ingredient was in the above content range.
  • the content of the mixture of adenosine, D-panthenol and niacinamide included as an active ingredient in the composition for preventing hair loss or promoting hair growth of the present disclosure is 0.0001 to 10% by weight, preferably 0.001 to 10% by weight relative to the total weight of the composition. 10% by weight.
  • the content of the mixture of adenosine, D-panthenol, and niacinamide is less than 0.0001% by weight relative to the total weight of the composition, the effect of promoting hair growth is insignificant, and when it exceeds 10% by weight, the stability of the formulation is deteriorated, which is not preferable.
  • the content of any one or more selected from the group consisting of Sauerkraut extract, Echo extract, zinc pyrithione and salicylic acid included as an additional active ingredient in the composition for preventing hair loss or promoting hair growth of the present disclosure is based on the total weight of the composition. 0.00001 to 10% by weight, preferably 0.0001 to 5% by weight.
  • the content of any one or more selected from the group consisting of the sauerkraut extract, Echo extract, zinc pyrithione and salicylic acid is less than 0.00001% by weight relative to the total weight of the composition, the synergistic effect in promoting hair growth is insignificant, and when it exceeds 10% by weight, the formulation It is not preferable because of its poor stability.
  • the weight ratio of the mixture of adenosine, D-panthenol and niacinamide is 1:0.3-5:0.2-8, preferably 1:0.5-4:0.3-6 (adenosine:D-panthenol:niacin) amide).
  • the mixture of adenosine, D-panthenol and niacinamide is combined in the specific weight ratio, the effect of preventing hair loss and promoting hair growth is excellent.
  • the composition for preventing hair loss or promoting hair growth of the present disclosure may be used as a pharmaceutical composition, a composition for quasi-drugs, a cosmetic composition, or a health functional food composition.
  • the composition of the present disclosure may be formulated in any form that can be applied to the skin, but may preferably be formulated in the form of an external preparation for skin.
  • the composition of the present disclosure may be prepared in a formulation that can be applied to the skin, such as liquid, cream, paste, or solid, for example.
  • any one or more selected from the group consisting of sauerkraut extract, eoseongcho extract, zinc pyrithione and salicylic acid may be included in the composition or formulation as an anti-hair loss agent or a hair growth promoter.
  • a solvent, solubilizer or emulsifier may be used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan may be used.
  • the formulation of the present disclosure is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component.
  • animal oil vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide
  • talc cellulose derivative
  • polyethylene glycol silicone
  • bentonite silica
  • talc talc
  • zinc oxide may be used as a carrier component. have.
  • lactose When the formulation of the present disclosure is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder, etc. may be used as a carrier component.
  • a propellant such as chlorofluorohydrocarbon, propane/butane or dimethyl ether may be additionally included.
  • composition of the present disclosure may include ingredients commonly used as external preparations that can be applied to the skin in addition to the active ingredients.
  • ingredients commonly used as external preparations that can be applied to the skin in addition to the active ingredients.
  • one or more additives selected from the group consisting of water, surfactants, humectants, lower alcohols, chelating agents, bactericides, antioxidants, preservatives, colorants and fragrances, etc. may be further included.
  • the present disclosure provides a product for hair or scalp comprising the composition for preventing hair loss or promoting hair growth.
  • the hair or scalp products include hair growth agents, scalp clinic agents, scalp scaling agents, scalp massage agents, scalp care agents, cleaners, shampoos, tonics, hair conditioners, hair lotions, gels, packs, creams, essences, powders, sprays, oils , but may be any one selected from the group consisting of soap, ointment, hair styling agent, hair dye and perm agent, but is not limited thereto.
  • the composition for preventing hair loss or promoting hair growth may be prepared in the form of a hair tonic or hair lotion (Preparation Examples 1 to 3).
  • composition for preventing hair loss or promoting hair growth of the present disclosure can be preferably used in a transdermal administration method such as directly applied to the skin or sprayed.
  • the present disclosure provides a health functional food composition comprising the composition for preventing hair loss or promoting hair growth.
  • the health functional food composition may be prepared by a method commonly used in the art. In the preparation, it can be prepared by adding raw materials and components commonly added in the art.
  • the dosage form of the health functional food may be manufactured without limitation as long as it is a dosage form recognized as a health functional food.
  • the health functional food of the present disclosure can be prepared in various types of dosage forms, and has the advantage of not having side effects that may occur during long-term administration of drugs using food as a raw material, and has excellent portability to prevent hair loss or promote hair growth. It can be taken as a supplement for
  • a mixture of adenosine, D-panthenol and niacinamide; And anti-hair loss or hair growth comprising the step of administering to a patient a composition for preventing or promoting hair growth comprising, as an active ingredient, any one or more selected from the group consisting of sauerkraut extract, Echo extract, zinc pyrithione and salicylic acid It provides a method of promotion.
  • the method for preventing hair loss or promoting hair growth may include treating the composition for preventing hair loss or promoting hair growth on the scalp or hair of a patient.
  • the term “administration” may refer to introducing a composition of the present disclosure by any suitable method.
  • the administration route of the composition of the present disclosure may be administered through any general route as long as it can reach the target tissue. Preferably, it can be administered transdermally, and among them, topical application is most preferable.
  • the number of times of application of the composition of the present disclosure may be determined according to the prescription, need or desire.
  • composition 1 for the treatment of hair loss was used 5 times a week for 6 months, and as a result, it was confirmed that an excellent hair growth promoting effect appeared (Experimental Examples 4 and 5).
  • the pharmaceutical composition, the quasi-drug composition, the cosmetic composition, or the health functional food composition according to the present disclosure includes the components according to the present disclosure within the content limit allowed by the relevant laws and regulations of each country.
  • composition for preventing hair loss and promoting hair growth of the present disclosure promotes the activity of dermal papilla cells, mitochondrial activity of dermal papilla cells, and Wnt/ ⁇ -catenin signaling system through a combination between specific active ingredients, thereby having a significant effect in preventing hair loss and promoting hair growth create a synergistic effect.
  • Preparation Example 1 Composition 1 for the treatment of hair loss (Hair Tonic)
  • a hair tonic was prepared in a conventional manner according to the prescription disclosed in Table 1 below.
  • Example 1 Ingredients ethanol castor oil glycerin adenosine D-Panthenol Niacinamide fragrances and colors Purified water Weight ratio (%) Comparative Example 1 55 5 3 0 0 0 appropriate amount remaining amount Comparative Example 2 55 5 3 One One One appropriate amount Example 1 55 5 3 1.6 0.9 0.5 appropriate amount Example 2 55 5 3 0.8 1.5 0.7 appropriate amount Example 3 55 5 3 0.75 0.75 1.5 appropriate amount Example 4 55 5 3 0.6 0.8 1.6 appropriate amount Example 5 55 5 3 0.3 One 1.7 appropriate amount
  • Preparation Example 2 Composition 2 for the treatment of hair loss (Hair Tonic)
  • a hair tonic was prepared in a conventional manner by adding one each of the extracts of H. sauerkraut, eoseongcho extract, zinc pyrithione, or salicylic acid.
  • Example 6 Ingredients ethanol castor oil glycerin adenosine D-Panthenol Niacinamide sewage extract Eoseongcho Extract zinc pyrithione salicylic acid fragrances and colors Purified water Weight ratio (%) Example 6 55 5 3 0.4 0.6 1.0 One appropriate amount remaining amount Example 7 55 5 3 0.4 0.6 1.0 One appropriate amount Example 8 55 5 3 0.4 0.6 1.0 One appropriate amount Example 9 55 5 3 0.4 0.6 1.0 One appropriate amount
  • Preparation Example 3 Composition 3 for the treatment of hair loss (hair lotion)
  • DPCs Human-derived dermal papilla cells
  • FBS fetal bovine serum
  • penicillin 100 unit/mL and streptomycin 100 ⁇ g/mL at 37° C. and 5% CO 2 cultured under conditions.
  • dispensing the cultured DPCs 3,000 cells/well in a 96-well plate, they were cultured for 24 h in 0.1% serum condition.
  • DMSO vehicle
  • DMSO vehicle
  • minoxidil 2 ⁇ g/ml as a positive control group
  • adenosine D-panthenol
  • niacinamide in a mixture of S. Extract, zinc pyrithione, and at least one of salicylic acid as shown in Table 4 below
  • CCK-8 was treated at 1:10 in the culture medium and incubated for 1 hour. After 1 hour, the absorbance of each well was measured at 450 nm. All experiments were repeated three times and the average of the absorbance values was calculated. The results were expressed as a percentage of the treatment group compared to the control group as 100.
  • DPCs Human-derived dermal papilla cells
  • FBS fetal bovine serum
  • penicillin 100 unit/mL and streptomycin 100 ⁇ g/mL at 37° C. and 5% CO 2 cultured under conditions.
  • dispensing the cultured DPCs 3,000 cells/well in a 96-well plate, they were cultured for 24 h in 0.1% serum condition.
  • DMSO vehicle
  • DMSO vehicle
  • minoxidil 2 ⁇ g/ml as a positive control group
  • adenosine D-panthenol
  • niacinamide in a mixture of S. Extract, zinc pyrithione, and at least one of salicylic acid as shown in Table 5 below
  • Table 5 Treated and incubated for 1 day.
  • the degree of cell proliferation was evaluated using the JC-1 method.
  • JC-1 was treated at 1:100 in the culture medium and incubated for 1 hour. After 1 hour, the fluorescence of each well was measured at 590 nm and 530 nm. All experiments were repeated three times and the average of the fluorescence values was calculated. The results were expressed as a percentage of the treatment group compared to the control group as 100.
  • the Wnt/ ⁇ -catenin signal activated in the dermal papilla occurs during the hair growth cycle, when transitioning from the catagen to the active phase, that is, from the beginning of hair growth to the active phase in which hair growth occurs.
  • the Wnt/ ⁇ -catenin signal weakens or disappears, causing the hair follicles to degenerate and hair loss. Therefore, in the mixture of adenosine, D-panthenol, and niacinamide of the present disclosure, the treatment group of at least one of sewage extract, seaweed extract, zinc pyrithione, and salicylic acid contributes to Wnt/ ⁇ -catenin signal amplification through this experiment. Confirmed.
  • wnt3a protein As a positive control to amplify the Wnt/ ⁇ -catenin signal, wnt3a protein was used, and as a negative control, DMSO was used. After seeding 3 x 10 4 Wnt Reporter HEK293A cells in each well of a 96-well plate in culture, adenosine, D-panthenol, and niacinamide of the present disclosure were added to the mixture of sauerkraut extract, seaweed extract, zinc pyrithione, and salicylic acid. At least one type was treated as shown in Table 6 below. Then, reporter assay was performed using Promega's Luciferase assay kit (E1960). The manufacturer's experimental method was followed, and Wnt/ ⁇ -catenin promoter activity was measured using a luminometer Victor (PerkinElmer, Waltham, Massachusetts, USA).
  • the hair growth effect of the composition 1 (Hair Tonic) for hair loss treatment or hair growth promotion of the present invention was tested on a total of 70 men and women with significantly less hair than normal or weak hair with symptoms of hair loss.
  • a total of 70 males and females were divided into 7 groups of 10 each, and Comparative Examples 1 and 2 and Examples 1 to 5 were used, and used 5 times a week for hair and scalp for 6 months.
  • researcher evaluation through clinical photography and evaluation through phototricogram were conducted.
  • the researcher's evaluation through clinical photos was evaluated with three items of 'good', 'slight', or 'no change' for Comparative Examples and Examples 2 and 6 months after application (Good: 50% to 75% improvement, Slight: 25% ⁇ 50% improvement, No change: no change).
  • the evaluation of the number of hairs per unit area and the average hair thickness through the phototricogram was measured for Comparative Examples and Examples 6 months after application, and the results are shown in Table 7.
  • Example 1 Slight Good Number of hairs per unit area (pieces/cm 2 ) Average hair thickness ( ⁇ m) (number of people) (number of people) (number of people) February June February June February June June June october June october June Comparative Example 1 8 7 2 3 0 0 125.2 ⁇ 20 126.9 ⁇ 14 43.6 ⁇ 8 45.2 ⁇ 3 Comparative Example 2 7 4 2 4 One 2 125 ⁇ 16 134 ⁇ 10 45.3 ⁇ 6 55.9 ⁇ 4 Example 1 6 4 3 3 One 3 119 ⁇ 10 135 ⁇ 10 44.2 ⁇ 10 53.4 ⁇ 3 Example 2 7 3 2 4 One 3 128.2 ⁇ 17 137 ⁇ 23 44.7 ⁇ 8 54.3 ⁇ 4 Example 3 3 2 5 4 2 4 124.4 ⁇ 15 153 ⁇ 17 41.3 ⁇ 7 62.5 ⁇ 2 Example 4 2 2 4 3 4 5 123.1 ⁇ 13 179 ⁇ 19 44 ⁇ 8 77.2 ⁇ 8 Example 5 2 One 4 4 4 5 120 ⁇ 20 169 ⁇ 17 42.5 ⁇ 4 69 ⁇ 6
  • the hair growth effect of the composition 2 for treating hair loss or for promoting hair growth of the present invention was tested on a total of 60 men and women with significantly less hair than normal or weak hair with symptoms of hair loss.
  • a total of 60 males and females were divided into 6 groups of 10 each, and Comparative Example 1 and Examples 6 to 9 were used, and used 5 times a week for hair and scalp for 6 months.
  • researcher evaluation through clinical photography and evaluation through phototricogram were conducted.
  • the researcher's evaluation through clinical photos was evaluated with three items of 'good', 'slight', or 'no change' for Comparative Examples and Examples 2 and 6 months after application (Good: 50% to 75% improvement, Slight: 25% ⁇ 50% improvement, No change: no change).
  • the evaluation of the number of hairs per unit area and the average hair thickness through the phototricogram was measured for Comparative Examples and Examples 6 months after application, and the results are shown in Table 8.
  • Example 1 9 8 One 2 0 0 133.2 ⁇ 10 130.8 ⁇ 10 40.6 ⁇ 4 40.4 ⁇ 6 Example 6 One One 3 4 6 5 131.8 ⁇ 10 199 ⁇ 13 44.5 ⁇ 3 86.9 ⁇ 3 Example 7 One 0 One 2 8 8 129.8 ⁇ 19 188 ⁇ 18 42.8 ⁇ 5 88.3 ⁇ 7 Example 8 2 0 4 3 4 7 134.5 ⁇ 10 185 ⁇ 19 45.4 ⁇ 8 83.5 ⁇ 9 Example 9 0 0 3 2 7 8 132.3 ⁇ 18 190 ⁇ 17 43.3 ⁇ 2 86 ⁇ 2
  • Formulation examples such as the hair tonic or hair lotion are only examples of the composition for preventing hair loss or promoting hair growth of the present disclosure, and it is common in the art to which the present invention pertains that the scope of the composition of the present disclosure is not limited only to these formulations. It will be obvious to those with knowledge.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une composition destinée à prévenir la chute des cheveux et à stimuler la pousse des cheveux, contenant un ingrédient destiné à induire la stimulation de la pousse des cheveux. En favorisant l'activité des cellules de papille dermique, l'activité mitochondriale des cellules de papille dermique, et l'activité de la voie de signalisation Wnt/ß-caténine par l'intermédiaire d'une combinaison d'ingrédients actifs spécifiques, la composition pour prévenir la chute des cheveux et stimuler la pousse des cheveux de la présente divulgation présente un effet synergique remarquable dans la prévention de la chute des cheveux et la stimulation de la pousse des cheveux.
PCT/KR2021/009057 2020-07-14 2021-07-14 Composition pour prévenir la chute des cheveux et stimuler la pousse des cheveux WO2022015055A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202180060665.XA CN116209425A (zh) 2020-07-14 2021-07-14 用于防止脱发和促进生发的组合物
JP2023503031A JP2023534287A (ja) 2020-07-14 2021-07-14 脱毛防止及び発毛促進用の組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20200086878 2020-07-14
KR10-2020-0086878 2020-07-14

Publications (1)

Publication Number Publication Date
WO2022015055A1 true WO2022015055A1 (fr) 2022-01-20

Family

ID=79555640

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/009057 WO2022015055A1 (fr) 2020-07-14 2021-07-14 Composition pour prévenir la chute des cheveux et stimuler la pousse des cheveux

Country Status (4)

Country Link
JP (1) JP2023534287A (fr)
KR (1) KR20220008790A (fr)
CN (1) CN116209425A (fr)
WO (1) WO2022015055A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102428299B1 (ko) 2022-02-14 2022-08-02 주식회사 아이두젠 노각나무 추출물을 포함하는 탈모예방 또는 양모촉진용 조성물
KR20240063217A (ko) 2022-10-28 2024-05-10 헤르바바이오(주) 양모 촉진용 허브 발효액 제조방법 및 이에 따라 제조된 허브 발효액

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070041890A (ko) * 2005-10-17 2007-04-20 (주)아모레퍼시픽 모발 성장 촉진용 외용제 조성물
KR101445553B1 (ko) * 2013-02-27 2014-09-29 케일럽 멀티랩 (주) 발모 촉진용 조성물
KR20150066811A (ko) * 2013-12-09 2015-06-17 주식회사 엘지생활건강 양모ㆍ육모 촉진용 화장료 조성물
KR102054160B1 (ko) * 2017-10-10 2019-12-10 유씨엘 주식회사 두피노화 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물
KR102090008B1 (ko) * 2019-01-30 2020-03-18 주식회사 리더스코스메틱 플럼코트 추출물을 유효성분으로 함유하는 탈모 방지용 화장료 조성물
KR102102578B1 (ko) * 2019-06-26 2020-04-21 코스맥스 주식회사 18β-글리시레틴산, D-판테놀 및 멘톨을 유효성분으로 포함하는 모근 강화용 화장료 조성물

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070041890A (ko) * 2005-10-17 2007-04-20 (주)아모레퍼시픽 모발 성장 촉진용 외용제 조성물
KR101445553B1 (ko) * 2013-02-27 2014-09-29 케일럽 멀티랩 (주) 발모 촉진용 조성물
KR20150066811A (ko) * 2013-12-09 2015-06-17 주식회사 엘지생활건강 양모ㆍ육모 촉진용 화장료 조성물
KR102054160B1 (ko) * 2017-10-10 2019-12-10 유씨엘 주식회사 두피노화 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물
KR102090008B1 (ko) * 2019-01-30 2020-03-18 주식회사 리더스코스메틱 플럼코트 추출물을 유효성분으로 함유하는 탈모 방지용 화장료 조성물
KR102102578B1 (ko) * 2019-06-26 2020-04-21 코스맥스 주식회사 18β-글리시레틴산, D-판테놀 및 멘톨을 유효성분으로 포함하는 모근 강화용 화장료 조성물

Also Published As

Publication number Publication date
CN116209425A (zh) 2023-06-02
KR20220008790A (ko) 2022-01-21
JP2023534287A (ja) 2023-08-08

Similar Documents

Publication Publication Date Title
US5663160A (en) Cosmetic or dermatological composition containing at least one saponin of the ginsenoside type, and its applications, especially for treating the hair
WO2013027984A2 (fr) Composition cosmétique contenant un composant de thé vert
KR20010057585A (ko) 피부외용제
WO2022015055A1 (fr) Composition pour prévenir la chute des cheveux et stimuler la pousse des cheveux
JP2024069595A (ja) 脱毛防止または毛髪成長促進用の組成物
KR101827771B1 (ko) 닥나무 추출물을 함유하는 여드름 개선용 화장료 조성물
KR102369387B1 (ko) 탈모방지 및 발모촉진용 화장료 조성물
KR101985356B1 (ko) 발효콩 추출물을 함유하는 피부 외용제 조성물
WO2013077569A1 (fr) Composition de traitement cutané à application topique comprenant un extrait de dendranthema indicum
KR20150030095A (ko) 인삼 추출물과 녹차 추출물을 함유하는 모발 또는 두피 상태 개선용 조성물
JP2006347959A (ja) 養毛剤
KR101252554B1 (ko) 피지분비 억제용 조성물
KR101438332B1 (ko) 포시티아사이드-에이를 포함하는 탈모방지 또는 발모촉진용 조성물
WO2022019573A1 (fr) Composition pour prévenir la chute de cheveux ou favoriser la pousse de cheveux comprenant un extrait de la partie aérienne de carottes
JP3908245B2 (ja) 養毛剤
WO2022255799A1 (fr) Composition destinée à prévenir la chute des cheveux et à stimuler la pousse des cheveux, contenant gypsophila paniculata l.
KR20010028372A (ko) 피부 미백용 화장료 조성물
WO2021157753A1 (fr) Composition pour prévenir la chute des cheveux et stimuler la repousse des cheveux
WO2022045385A1 (fr) Composition pour prévenir la chute des cheveux ou stimuler la repousse des cheveux
WO2020111047A1 (fr) Composition pour cuir chevelu et cheveux
WO2021149853A1 (fr) Composition pour la prévention de la chute des cheveux ou la stimulation de la pousse des cheveux
KR102537521B1 (ko) 탈모 방지 및 발모 촉진용 조성물
KR20120075766A (ko) 탈모방지 또는 발모촉진용 조성물
WO2024010355A1 (fr) Composition antivieillissement contenant un extrait de lie de vin de gosori
WO2024049229A1 (fr) Composition cosmétique pour prévenir ou améliorer des maladies de la peau, comprenant un composé dérivé de morus alba en tant que principe actif

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21842766

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2023503031

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC. EPO FORM 1205A DATED 12.05.2023.

122 Ep: pct application non-entry in european phase

Ref document number: 21842766

Country of ref document: EP

Kind code of ref document: A1