WO2024010355A1 - Composition antivieillissement contenant un extrait de lie de vin de gosori - Google Patents

Composition antivieillissement contenant un extrait de lie de vin de gosori Download PDF

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Publication number
WO2024010355A1
WO2024010355A1 PCT/KR2023/009485 KR2023009485W WO2024010355A1 WO 2024010355 A1 WO2024010355 A1 WO 2024010355A1 KR 2023009485 W KR2023009485 W KR 2023009485W WO 2024010355 A1 WO2024010355 A1 WO 2024010355A1
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Prior art keywords
aging
skin
gosori
sake lees
extract
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PCT/KR2023/009485
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English (en)
Korean (ko)
Inventor
우지은
신승우
조은애
정은선
조신환
김명옥
박덕훈
Original Assignee
바이오스펙트럼 주식회사
스킨큐어 주식회사
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Publication of WO2024010355A1 publication Critical patent/WO2024010355A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to an anti-aging composition containing an extract of Gosori sake sake lees. More specifically, the present invention is a sake lees extract that improves skin aging through the effect of suppressing cellular aging caused by oxidative stress, promoting collagen synthesis, suppressing elastase activity, suppressing secretion of inflammatory substances, promoting sebum secretion, and whitening effect. It relates to an anti-aging composition containing as an active ingredient.
  • Aging causes disharmony in the skin's immune system, which causes various skin diseases.
  • the skin is the organ where aging primarily occurs, and much research has been conducted in the cosmetics field to delay or prevent it.
  • skin aging begins to progress around the age of 25 and progresses in earnest around the age of 40.
  • Skin aging is divided into extrinsic aging and intrinsic aging.
  • Intrinsic aging is a natural phenomenon caused by degenerative changes that occur in proportion to the progression of time as one ages. Changes in the external appearance of the skin related to skin aging include dry skin, sagging skin, and wrinkles due to decreased moisture and sebum secretion, and skin diseases include seborrheic keratosis and sunspots.
  • the representative trigger of extrinsic aging is reactive oxygen species, which are generated from ultraviolet rays, pollution, inflammation, and the cell's own metabolic process, and act to promote cellular aging.
  • Gosorisul is a traditional Jeju liquor and is also called Omegisul.
  • “Omegi rice cake” is made by kneading millet alone or with rice, boiling it in water, and going through a fermentation process using malt or yeast. Afterwards, soju is distilled using a gosori, an earthenware vessel for boiling soju, and the remaining dregs become sake lees. In the case of this type of sake lees, it was a discarded resource as a brewing by-product, and little research on its physiological activity has been conducted so far.
  • the present inventors continued research to develop a natural anti-aging composition with high stability and safety and no skin side effects.
  • the results showed that the sake lees extract from Gosori Sul has an effect of suppressing cellular aging caused by oxidative stress, promoting collagen synthesis, By discovering that it can simultaneously exhibit an elastase activity inhibition effect, an inflammatory substance secretion inhibition effect, a sebum secretion promotion effect, and a whitening effect, it was discovered that it is a useful ingredient for anti-aging, and the present invention was completed.
  • One object of the present invention is to provide an anti-aging composition containing sake lees extract from Gosori Sul as an active ingredient.
  • Another object of the present invention is to provide a cosmetic composition containing the anti-aging composition.
  • Another object of the present invention is to provide a method for preventing or improving skin aging using the composition.
  • the present invention relates to an anti-aging composition containing sake lees extract from Gosori Sul as an active ingredient. More specifically, the present invention relates to a cosmetic composition containing sake lees extract from Gosori Sul as an active ingredient.
  • the composition is free from skin irritation and cytotoxicity and has excellent human safety, while suppressing cellular aging caused by oxidative stress. , It can improve skin aging by promoting collagen synthesis, suppressing elastase activity, suppressing secretion of inflammatory substances, promoting sebum secretion, and effectively suppressing melanin production.
  • the present invention provides an anti-aging composition containing an extract of sake lees from Gosori Sul as an active ingredient.
  • Gosori alcohol of the present invention is a traditional liquor of Jeju Island, mixed with millet and rice, kneaded, boiled in boiling water, fermented using malt and yeast, and then distilled in Gosori, an earthenware vessel for boiling soju.
  • the Gosori liquor unlike traditional liquor in other regions, is characterized by mixing millet and rice, kneading and fermenting.
  • the mixture of millet and rice is at a weight ratio of 1:9 to 9:1, preferably 2:8 to 8:2, more preferably 3:7 to 7:3, even more preferably 5. It can be achieved with a weight ratio of :5.
  • the millet is the grain remaining after removing the fruit of the millet. It is rich in protein, second only to soybeans among grains, contains more unsaturated fatty acids than rice or barley, contains carotene that is not found in ordinary grains, and has a savory taste.
  • the rice is the remaining grains after removing the fruit of the rice plant, and unlike the millet, it contains a lot of starch.
  • the content of the millet is less than the above range, the sensory properties (particularly the savory taste) due to the content of the millet are reduced, which not only poses a problem in the sensory quality of the high-soured liquor produced, but also the useful content contained in the millet reduces the high-sourized liquor. There is a problem in that very little remains in the sake lees, making the effects described below very weak.
  • the content of millet exceeds the above range, there is an advantage that the sensory quality of gosori liquor produced is improved due to the increase in savory taste due to the inclusion of millet, and the above-mentioned useful components contained in millet are used as sake lees of gosori liquor.
  • the effect described below is excellent because a large amount remains in the rice, but there is a problem that the quality of Gosori liquor is reduced because the rice content is relatively reduced and fermentation does not occur sufficiently.
  • the yeast is preferably a fermenting microorganism of the genus Aspergillus ( Aspergillus spp.), and the yeast is preferably a fermenting microorganism of the genus Saccharomyces ( Sacchraromycess spp.).
  • the sake lees of the high-sori liquor of the present invention is the liquor residue remaining after producing the high-sori liquor.
  • the “sake lees extract of Gosori liquor” is extracted from the sake lees of Gosori liquor, and the “extract” is obtained by immersing the target substance in various solvents and then extracting it at room temperature or at a heated state for a certain period of time. It refers to the results such as the liquid component obtained by fractionation and the solid component obtained by removing the solvent from the liquid component. In addition, in addition to the above results, it can be comprehensively interpreted to include all dilutions of the results, concentrates thereof, crude preparations, purifications, etc. of the above results.
  • extract of the highly fermented liquor of the present invention can be extracted using a conventional solvent known in the art, and the extracted liquid can be used in liquid form or after being concentrated and/or dried.
  • the solvent used is water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.), a mixed solvent of the lower alcohol and water, acetone, ethyl acetate, chloroform, or 1,3- Any solvent of butylene glycol can be used.
  • extraction may be performed using methanol, ethanol, or butanol.
  • the degree of extraction and loss of the active ingredients of the extract may vary depending on the organic solvent used for extraction, so it is desirable to select and use an appropriate organic solvent.
  • the extraction method is not particularly limited to this, but includes cold needle extraction, ultrasonic extraction, or reflux cooling extraction, and is preferably performed using the ultrasonic extraction method.
  • the sake lees extract from the high-steaming liquor can be obtained through a conventional purification process in addition to extraction using the extraction solvent.
  • various additional purification methods such as separation using ultrafiltration membranes with a certain molecular weight cut-off value, separation by various chromatographs (designed for separation according to size, charge, hydrophobicity, or affinity).
  • Sake lees extract can also be obtained through the obtained fraction.
  • the sake lees of Gosori sake are shaded and ground, then 0.5 to 20 times the weight of the dried sample, preferably 1 to 15 times the amount of water, C1 to C4 lower alcohol such as ethanol, methanol, etc.
  • a mixed solvent of water and ethanol at room temperature for about 20 to 70 hours, preferably 40 to 50 hours, using extraction methods such as stirred extraction, hot water extraction, cold immersion extraction, reflux cooling extraction, or ultrasonic extraction.
  • the extract obtained after ultrasonic extraction can be filtered, concentrated under reduced pressure, or dried to obtain a sake lees extract.
  • the “anti-aging” refers to reducing or preventing aging or death of skin cells or damage caused by external pressure, fine or coarse wrinkles, decreased skin elasticity, etc., through cell aging inhibition, prevention, and regenerative effects. Or it means improving. Therefore, “anti-aging” in the present invention includes preventing or improving skin wrinkles, preventing or improving skin elasticity, promoting skin regeneration, preventing, reducing, or improving skin inflammation, and preventing or improving skin whitening. can be considered. Additionally, the term “anti-aging” may be used interchangeably with aging improvement or skin aging improvement in this specification.
  • the Gosori liquor sake lees extract of the present invention has an effect of suppressing cellular aging caused by oxidative stress, an effect of promoting collagen synthesis, an effect of suppressing elastase activity, an effect of suppressing secretion of inflammatory substances, an effect of promoting sebum secretion, and a whitening effect. It is very useful in preventing, improving and treating skin aging.
  • prevention refers to suppressing or minimizing cell aging caused by oxidative stress, suppressing or minimizing skin wrinkles by promoting the synthesis of skin collagen, suppressing the activity of elastase, and promoting sebum secretion. , increases skin elasticity by promoting the synthesis of skin collagen, suppressing the activity of elastase, and promoting sebum secretion, increases anti-inflammation of the skin by suppressing or reducing the secretion of inflammatory substances, or increases the production of melanin. It refers to suppressing and minimizing skin aging by increasing skin whitening.
  • the term “improvement” or “treatment” refers to suppressing or minimizing cell aging caused by oxidative stress, or reducing skin wrinkles by promoting the synthesis of skin collagen, suppressing the activity of elastase, and promoting sebum secretion. Inhibit or minimize, increase skin elasticity by promoting the synthesis of skin collagen, suppressing the activity of elastase, and promoting sebum secretion, or increasing anti-inflammation of the skin by suppressing or reducing the secretion of inflammatory substances, It refers to preventing skin aging and returning the skin condition to its previous state by increasing the production of melanin and increasing skin whitening.
  • the cells include all cells existing in vivo or cultured in vitro .
  • the cells can be classified in various ways based on cell shape and location, and examples include skin cells (epidermis, dermis, dermal papilla cells, melanin, etc.), fibroblasts, adipocytes, stem cells, and vascular cells. .
  • cellular senescence was induced in human fibroblasts and the degree of cellular senescence was examined depending on the concentration of the high-solid sake lees extract of the present invention. As a result, as the concentration of the highly-sulliary sake lees extract increased, cellular senescence decreased. It was confirmed that the sake lees extract from Gosori Sul has an anti-aging effect (see Figure 1).
  • an inflammatory response was induced in mouse macrophages and the degree of secretion of inflammatory substances (nitrite) according to the concentration of the sake lees extract of high-sori liquor was examined.
  • nitrite nitrite
  • the sake lees extract of high-sori liquor was secreted by the sake lees extract of high-sori liquor.
  • production was found to be reduced, and it was confirmed that the sake lees extract from Gosori Sul has anti-inflammatory and anti-aging effects by suppressing the secretion of inflammatory substances (see Figure 4).
  • the anti-aging composition containing the sake lees extract of Gosori sake of the present invention as an active ingredient contains 0.0001 to 20.0% by weight, preferably 0.001 to 10.0% by weight, of the sake lees extract of Gosori alcohol based on the total weight of the composition. . If the content of the sake lees extract of the Gosori liquor is less than 0.0001% by weight, anti-aging effect cannot be expected, and if it exceeds 20.0% by weight, the increase in anti-aging effect due to increase in content is minimal and difficulties arise in manufacturing the formulation. .
  • the anti-aging composition of the present invention may be provided as an anti-aging cosmetic composition containing an extract of sake lees from Gosori Sul as an active ingredient.
  • the cosmetic composition may preferably be in the form of a functional cosmetic, and the functionality may be skin anti-aging, including skin wrinkle improvement, skin antioxidant, skin anti-inflammatory, skin elasticity improvement, skin regeneration, skin whitening, etc.
  • the sake lees extract of Gosori Sul is as described above, and the sake lees extract of Gosori Sul has skin anti-aging effects such as skin wrinkle improvement effect, skin antioxidant effect, skin elasticity enhancement effect, skin anti-inflammatory effect, and skin whitening effect. Because it has an effect, it can be usefully used as a cosmetic composition for skin anti-aging purposes such as improving skin wrinkles, skin antioxidant, improving skin elasticity, skin anti-inflammatory, skin regeneration, and skin whitening.
  • the cosmetic composition may additionally contain ingredients commonly used in cosmetic compositions in addition to the sake lees extract of Gosori wine as an active ingredient with anti-aging effect.
  • ingredients commonly used in cosmetic compositions in addition to the sake lees extract of Gosori wine as an active ingredient with anti-aging effect.
  • it may include conventional auxiliaries and carriers such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings.
  • the cosmetic composition can be manufactured in any formulation commonly manufactured in the art.
  • it can be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray.
  • it can be manufactured in formulations such as nutritional cream, astringent lotion, softening lotion, lotion, essence, nutritional gel, or massage cream.
  • it is not particularly limited thereto.
  • the formulation of the cosmetic composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide are used as carrier ingredients. It can be used.
  • lactose When the formulation of the cosmetic composition is powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder can be used as the carrier ingredient.
  • chlorofluorohydrocarbon May contain propellants such as propane/butane or dimethyl ether.
  • a solvent, solubilizing agent, or emulsifying agent may be used as a carrier component.
  • a solvent, solubilizing agent, or emulsifying agent may be used as a carrier component.
  • water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan can be used. there is.
  • the carrier ingredients include water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, and miso.
  • a liquid diluent such as ethanol or propylene glycol
  • a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester
  • miso Crystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used.
  • the carrier ingredients include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, and fatty acid.
  • Amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester can be used.
  • the cosmetic composition containing the sake lees extract of Gosori sake of the present invention as an active ingredient contains 0.0001 to 20.0% by weight, preferably 0.001 to 10.0% by weight, of the sake lees extract of Gosori alcohol based on the total weight of the composition. If the content of the sake lees extract of the Gosori liquor is less than 0.0001% by weight, anti-aging effect cannot be expected, and if it exceeds 20.0% by weight, the increase in the effect due to increase in content is insignificant and difficulties arise in manufacturing cosmetic formulations. .
  • the sake lees extract from Gosori liquor according to the present invention is a natural substance that is harmless to the human body and has almost no toxicity or side effects, so it can be safely used even for long-term use, and can be safely applied to cosmetic compositions containing it.
  • the sake lees extract which is an active ingredient of the present invention, does not irritate the skin and has excellent human safety, but also has an effect of inhibiting cell aging caused by oxidative stress, promoting collagen synthesis, inhibiting elastase activity, inhibiting secretion of inflammatory substances, promoting sebum secretion, and It can be usefully used as an anti-aging cosmetic composition that effectively improves skin aging by simultaneously having a whitening effect.
  • Figure 1 is a diagram showing the cell senescence inhibitory effect of sake lees extract when oxidative stress is induced in normal human fibroblasts according to an embodiment of the present invention.
  • Figure 2 is a diagram showing the collagen synthesis promoting effect of sake lees extract in normal human fibroblasts according to an embodiment of the present invention.
  • Figure 3 is a diagram showing the elastase activity inhibitory effect of sake lees extract according to an embodiment of the present invention.
  • Figure 4 is a diagram showing the inhibitory effect of the sake lees extract on the secretion of inflammatory substances when an inflammatory response is induced in mouse macrophages according to an embodiment of the present invention.
  • Figure 5 is a diagram showing the effect of promoting sebum secretion after treating human sebum cells with sake lees extract according to an embodiment of the present invention.
  • Figure 6 is a diagram showing the whitening effect of sake lees extract on human melanocytes according to an embodiment of the present invention.
  • Example 2 Confirmation of the inhibitory effect of cellular senescence induced by oxidative stress in human fibroblasts
  • HDFs Human dermal fibroblasts
  • sake lees extract reduced the increased SA- ⁇ -gal activity caused by hydrogen peroxide treatment in human fibroblasts. From this, it was found that sake lees extract has an excellent effect of suppressing cellular aging caused by oxidative stress in human fibroblasts in a concentration-dependent manner.
  • the amount of collagen synthesis in the sample prepared above was determined by measuring procollagen type I C-peptide (PICP, Type I C-peptide) using TAKARA's collagen measurement kit (MK101, Procollagen Type I C-peptide EIA kit). The amount was measured. The results are shown in Figure 2.
  • Mouse macrophages (RAW264.7, macrophage) were inoculated at 2 ⁇ 10 5 per well in a 24-well plate containing RPMI medium supplemented with 10% FBS (fetal bovine serum), and then incubated in a 5% concentration CO 2 incubator. Cultured for 24 hours at 37°C. Afterwards, the test substance was dissolved in RPMI medium supplemented with 2% FBS, pretreated for 2 hours, and then LPS (Lipopolysaccharide 100 ng/mL), which can induce an inflammatory response, was treated in each well.
  • FBS fetal bovine serum
  • sake lees extract reduced the increased nitrite secretion due to LPS treatment in mouse macrophages. From this, it was found that sake lees extract was effective in suppressing the secretion of inflammatory substances caused by inducing an inflammatory response in mouse macrophages.
  • the cells were stained with Nile red for 15 minutes at room temperature, and then the nuclei were stained with Hoechst 33342 to confirm the total number of cells, and the degree of sebum secretion was observed under a fluorescence microscope. Micrographs were analyzed with ImageJ, and the results are shown in Figure 5.
  • Example 7 Confirmation of whitening effect in human melanocytes
  • Example 8 Experiment to confirm the safety of sake lees extract on human skin
  • An external skin preparation containing 1% of the sake lees extract of Example 1 was prepared with the ingredient contents shown in Table 1 below.
  • an external skin agent purified water, glycerin, and butylene glycol were mixed and dissolved at 70°C (aqueous part), and the remaining ingredients except the above three ingredients and trimethanolamine were dissolved at 70°C (oil part).
  • the oil part was added to the water part and stirred with a homomixer (Tokushu Kika, Japan) for primary emulsification, and trimethanolamine was finally added thereto. After removing the bubbles generated in the mixed solution, it was cooled to room temperature to prepare an external skin preparation.
  • control group test group Purified water 72 71 glycerin 8.0 8.0 Butylene glycol 4.0 4.0 Gosori Sake Sake Lid Extract 0 1.0 Caprylic Capri Triglyceride 8.0 8.0 squalane 5.0 5.0 Cetearyl Glucuside 1.5 1.5 Sorbitan Stearate 0.4 0.4 cetearyl alcohol 1.0 1.0 Trimethanolamine 0.1 0.1 total weight 100 100
  • test matter Number of subjects who responded average Skin irritation index 30 minutes later 24 hours later One 2 3 4
  • a softening lotion containing Gosori liquor sake lees extract as an active ingredient was prepared according to a conventional method.

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

La présente invention concerne une composition antivieillissement contenant un extrait de lie de vin de Gosori. L'extrait de la lie de vin de Gosori peut être avantageusement utilisé en tant que produit cosmétique, car il présente non seulement les effets d'inhibition du vieillissement cellulaire provoqué par le stress oxydatif, de promotion de la synthèse du collagène, de suppression de l'activité de l'élastase, d'inhibition de la sécrétion de substance inflammatoire, de la stimulation de la production de sébum, et de la fourniture d'un blanchiment de la peau simultanément, permettant ainsi une prévention et un soulagement efficaces du vieillissement de la peau, mais est également exempt d'irritation cutanée et présente une excellente sécurité pour le corps humain.
PCT/KR2023/009485 2022-07-07 2023-07-05 Composition antivieillissement contenant un extrait de lie de vin de gosori WO2024010355A1 (fr)

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KR10-2022-0083698 2022-07-07
KR1020220083698A KR20240006879A (ko) 2022-07-07 2022-07-07 고소리술 술지게미 추출물을 포함하는 항노화용 조성물

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05310590A (ja) * 1992-05-15 1993-11-22 Soken Kk 活性酸素消去剤
JP2015232072A (ja) * 2014-06-09 2015-12-24 共栄化学工業株式会社 化粧料
JP2019024360A (ja) * 2017-07-27 2019-02-21 株式会社車多酒造 エチル−α−Ｄ−グルコシドの製造方法及びその利用
KR20190048564A (ko) * 2017-10-31 2019-05-09 에스케이바이오랜드 주식회사 용암해수를 이용하여 발효한 오메기주의 농축물을 포함하는 피부의 주름개선, 탄력개선 또는 보습용 화장료 조성물
KR20220086400A (ko) * 2020-12-16 2022-06-23 정회철 이화주 부산물을 유효성분으로 포함하는 피부 미백 또는 재생용 화장료 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05310590A (ja) * 1992-05-15 1993-11-22 Soken Kk 活性酸素消去剤
JP2015232072A (ja) * 2014-06-09 2015-12-24 共栄化学工業株式会社 化粧料
JP2019024360A (ja) * 2017-07-27 2019-02-21 株式会社車多酒造 エチル−α−Ｄ−グルコシドの製造方法及びその利用
KR20190048564A (ko) * 2017-10-31 2019-05-09 에스케이바이오랜드 주식회사 용암해수를 이용하여 발효한 오메기주의 농축물을 포함하는 피부의 주름개선, 탄력개선 또는 보습용 화장료 조성물
KR20220086400A (ko) * 2020-12-16 2022-06-23 정회철 이화주 부산물을 유효성분으로 포함하는 피부 미백 또는 재생용 화장료 조성물

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