WO2010058986A2 - Composition cosmétique contenant des extraits d'adenophora triphylla var. japonica hara, d'angelica tenuissima et de plantes médicinales - Google Patents

Composition cosmétique contenant des extraits d'adenophora triphylla var. japonica hara, d'angelica tenuissima et de plantes médicinales Download PDF

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WO2010058986A2
WO2010058986A2 PCT/KR2009/006839 KR2009006839W WO2010058986A2 WO 2010058986 A2 WO2010058986 A2 WO 2010058986A2 KR 2009006839 W KR2009006839 W KR 2009006839W WO 2010058986 A2 WO2010058986 A2 WO 2010058986A2
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Prior art keywords
honey
roasted
extract
mixture
cosmetic composition
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PCT/KR2009/006839
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English (en)
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WO2010058986A3 (fr
Inventor
Jun Seong Park
Dong Hyun Kim
Nok Hyun Park
Hye Yoon Park
Jae Kyoung Lee
Duck Hee Kim
Han Kon Kim
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Amorepacific Corporation
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Priority to US13/129,932 priority Critical patent/US9480638B2/en
Priority to JP2011536265A priority patent/JP5577347B2/ja
Priority to CN200980145095.3A priority patent/CN102209526B/zh
Publication of WO2010058986A2 publication Critical patent/WO2010058986A2/fr
Publication of WO2010058986A3 publication Critical patent/WO2010058986A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the present invention relates to a cosmetic composition containing, as an active ingredient, a mixture of extracts of honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima Nakai , processed using a medicinal herb processing technique, and of extracts of medicinal herbs such as Lycium chinense Mill or Paeonia suffruticosa , and thus shows excellent antioxidant and skin-moisturizing effects.
  • a traditional Chinese medicine manufacturing technique using a medicinal herb processing technique is called “Po-je”, “Hap-hwa”, “Hap-yak”, “Su-chi”, “Po-ja”, “Beob-je” and “Su-sa” in Korean.
  • This medicine manufacturing technique comprises changing the inherent properties of medicinal herbs by processing the medicinal herbs on the basis of Chinese medicine theory.
  • the objects of processing medicinal herbs are to clarify medicine, facilitate the storage of medicines, reduce or remove the toxicity or side effects of medicines, change the properties of medicines to make the medicines more effective, enhance the therapeutic effects of medicines, and eliminate offensive odors and tastes of medicines to facilitate the intake of the medicines.
  • raw materials having various effects including skin whitening, wrinkle reduction and skin protection, are screened and added.
  • An antioxidant effect removes reactive oxygen species, which are the cause of skin aging, to retard or prevent skin aging, makes a dark and inelastic skin fresh and clear, and makes the skin appear healthy.
  • materials are known to have the antioxidant effect, and only a small number of the materials that are currently used are chemically synthesized.
  • the skin functions as an important barrier to protect the body from external factors.
  • the barrier function is a protective function to defend the body from various external stimuli, for example chemicals, atmospheric pollutants, dry environments and UV rays, and to prevent anexcessive loss of water from the body through the skin.
  • This protective function can be maintained when the horny layer consisting of keratinocytes is maintained in a normal state.
  • the horny layer (stratum corneum), which is the outermost layer of the epidermis,is formed from keratinocytes and consists of differentiated keratinocytes and lipid layers surrounding these keratinocytes (Marcelo C. L. et al, J. Invest. Dermatol., 80, pp37-44, 1983).
  • Keratinocytes are characteristic cells formed as a result of a process in which basal cells that continuously proliferate in the basal layer of the epidermis are pushed up to the surface of the skin while undergoinggradual changes in their shape and function. After the passage of a given period of time, old keratinocytes are shed from the skin’s surface, and new keratinocytes function in place of the shed cells. This repeated and serial process is called differentiation or keratinization of epidermal cells.
  • keratinocytes produce natural moisturizing factors (NMFs) and intracellular lipids (ceramides, cholesterols, fatty acids, etc.) while forming a horny layer, which impart solidity and flexibility to the horny layer that consequently will function as the skin barrier.
  • NMFs natural moisturizing factors
  • intracellular lipids ceramides, cholesterols, fatty acids, etc.
  • the horny layer is highly susceptible to functional loss by various factors, for exampleliving and behavioral factors such as excessive face washing and bathing, environmental factors such as dry atmosphere, contaminants, etc., and endogenous disorders such as atopic dermatitis and senile pruritus. With recent substantial increases of various harmful factors, the number of patients who complain of dry skin conditions and consequential disorders has gradually increased.
  • the present inventors have conducted studies to solve the above-mentioned problems occurring in the prior art and to find raw materials having improved antioxidant and skin moisturizing effects and, as a result, have found that a mixture of extracts of honey-roasted Adenophora triphylla var. japonica Hara , honey-roasted Angelica tenuissima and medicinal herbs such as Lycium chinense Mill. and Paeonia suffruticosa Andrews has excellent antioxidant and skin-moisturizing effects, and have thereby completed the present invention.
  • An object of the present invention is therefore to provide a cosmetic composition containing extracts of processed medicinal herbs and extracts of medicinal herbs that shows excellent antioxidant and skin-moisturizing effects.
  • the cosmetic composition of the present invention contains, as an active ingredient, a mixture of extracts of honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima.
  • the cosmetic composition of the present invention may further contain an extract of at least one of Lycium chinense Mill . and Paeonia suffruticosa Andrews in addition to said mixture.
  • Adenophora triphylla var. japonica Hara (or as alternatives, Adenophora polyantha Naka, Adenophora triphylla var. hirsuta Naka, Adenophora lilifolia Ledeb., Adenophora stricta Miq., Adenophora taquetii Lev., or Adenophora palustris Kom. ) used in the present invention has an extended cylindrical form and is curved, and has root branches in some cases. The rhizome is marked with whorled lateral wrinkles in the upper part.
  • the outer surface of the root is pale yellowish white to pale grayish brown in colour, and has the distinct lateral wrinkles in the upper part and both longitudinal and lateral wrinkles in the lower part.
  • the root is light and easy to snap off.
  • the snapped surface is milky white with many pores.
  • Angelica tenuissima Nakai (or as alternatives, Ligusticum sinense Oliv , or Ligusticum jeholense Nakai et Kitagaw ) used in the present invention has an irregular, exended cylindrical form having splits, and has tip marks remaining on the root head.
  • the outer surface is grayish brown in colour and hard.
  • the snapped surface is yellowish white with a rough surface, and is sometimes empty in the center. It has a characteristic smell and a hot taste.
  • Paeonia suffruticosa Andrews (or as alternatives, Paeonia suffruticosa var. spontanea Rehd , or Paeonia szechuanica Fang. ) used in the present invention is a tubular or semi-tubular bark.
  • the outer surface is dark brown to purple brown in colour and has long and small oval root marks along the transverse direction and longitudinal wrinkles, and the inner surface is pale grayish brown to dark purple in colourand flattened.
  • the snapped surface is rough.
  • the inner surface and the snapped surface have white crystals attached thereto.
  • Lycium chinense Mill. (or as an alternative, Lycium barbarum L .) used in the present invention has a tubular or semi-tubular form.
  • the outer surface is yellow to grayish brown, and the inner surface is gray to grayish brown.
  • the periderm is scale-shaped and easily peeled off.
  • the snapped surface is grayish white to grayish brown in colour and coarse without fibers.
  • the texture is light.
  • Adenophora triphylla var. japonica Hara and Angelica tenuissima Nakai used in the present invention are processed using a medicinal herb processing technique of roasting honeyed medicinal herbs.
  • boiled honey is diluted in a suitable amount of warm water, and medicinal herbs are sprayed with, or immersed in, the honeyed water (for 30 minutes to 3 hours), roasted with a weak fire to a specified extent (at a temperature of 100-180 °C for about 10 minutes to 1 hour), and dried.
  • 25-30 kg of honey is used per 100 kg of medicinal herbs.
  • honey is added to each of Adenophora triphylla var. japonica Hara and Angelica tenuissima Nakai in an amount of 20-30 wt% based on the weight of the respectivemedicinal herb and allowed to absorb into the medicinal herb for about 30 minutes to 1 hour.
  • the honeyed medicinal herb is roasted at a temperature of 100 to 180 °C for about 10 minutes to 1 hour.
  • the temperature and time in the roasting technique are not limited to the above-specified temperature and time and can be easily selected by a person skilled in the art.
  • the organic solvent that is used in the present invention can be selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate, chloroform, and mixtures of these organic solvents with water. Preferably, 80% ethanol is used.
  • the extraction temperature is preferably 10-80 °C and the extraction time is preferably 6-24 hours. If the extraction temperature and time are outside thesespecified ranges, extraction efficiency can be reduced or changes in the components of the extracts can occur.
  • the extract may be macerated at room temperature according to a conventional method known in the art, and the macerated extract may be heated and filtered, thus obtaining a liquid-phase material.
  • the liquid-phase material may additionally be evaporated, spray-dried or freeze-dried, thus obtaining an extract.
  • the content of the mixture in the cosmetic composition is less than 0.0001 wt%, the desired effects of the extracts cannot be obtained, and if the content exceeds 30 wt%, a further increase in the content will not lead to a significant increase in the effects of the extracts.
  • the mixture of the extracts in the cosmetic composition of the present invention contains, based on the total weight of the mixture, 30-70 wt% of the honey-roasted Adenophora triphylla var. japonica Hara extract, 30-70 wt% of the honey-roasted Angelica tenuissima Nakai extract, 10-20 wt% of the Paeonia suffruticosa Andrews extract and 10-20 wt% of the Lycium chinense Mill extract.
  • the mixture contains the honey-roasted Adenophora triphylla var. japonica Hara extract, the honey-roasted Angelica tenuissima Nakai extract, Lycium chinense Mill extract and the Paeonia suffruticosa Andrews extract at a ratio of 2-4 : 2-4 : 1 : 1.
  • the cosmetic composition of the present invention contains the above-described medicinal herb extracts as active ingredients and exhibits excellent antioxidant and skin-moisturizing effects.
  • the cosmetic composition of the present invention contains either a mixture of extracts of honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima Nakai or a mixture containing an extract of Lycium chinense Mill. or Paeonia suffruticosa in addition to the extracts of the honey-roasted plants, and thus showsexcellent antioxidant and skin-moisturizing effects.
  • FIG. 1 shows the results obtained by transfecting HaCaT cells, used in the present invention, with a PPRE promoter/reporter plasmid and a PPAR ⁇ expression plasmid, treating the transfected cells with medicines and measuring the luciferase activity of the cells (Prep : Preparation Example, Ex : Example).
  • FIG. 2 shows the results obtained by transfecting HaCaT cells with a PPAR ⁇ expression plasmid and a PPRE promoter/reporter plasmid, treating the transfected cells with medicines and measuring the luciferase activity of the cells (Prep : Preparation Example, Ex : Example).
  • FIG. 3 is a graphic diagram showing the effect of a mixture of herbal extracts according to the present invention on the restoration of damaged skin barrier (Prep : Preparation Example, Ex : Example).
  • FIG. 4 is a graphic diagram showing the effect of a mixture of herbal extracts according to the present invention on the skin’s water-holding capacity (Prep : Preparation Example, Ex : Example).
  • the dried Adenophora triphylla var. japonica Hara, Angelica tenuissima Nakai, Lycium chinense Mill and Paeonia suffruticosa were mixed together at a weight ratio of 1:1:1:1 to prepare 2 kg of the mixture.
  • the mixture was added to 5 l of 80 % ethanol aqueous solution, extracted three times under reflux, and then dipped at 15 °C for 1 day. Then, the extract was filtered through filter cloth and centrifuged to separate into a residue and a filtrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 200 g of a mixed herbal extract.
  • the dried Adenophora triphylla var. japonica Hara, Angelica tenuissima Nakai, Lycium chinense Mill and Paeonia suffruticosa were mixed together at a weight ratio of 3:3:1:1 to prepare 2 kg of the mixture.
  • the mixture was added to 5 l of 80 % ethanol aqueous solution, extracted three times under reflux, and then dipped at 15 °C for 1 day. Then, the extract was filtered through filter cloth and centrifuged to separate into a residue and afiltrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 230 g of a mixed herbal extract.
  • honey-roasted Adenophora triphylla var. japonica Hara, honey-roasted Angelica tenuissima Nakai, honey-roasted Lycium chinense Mill and honey-roasted Paeonia suffruticosa prepared in Preparation Examples 5, 6, 7 and 8, respectively, were mixed togetherat a weight ratio of 1:1:1:1 to prepare 2 kg of the mixture.
  • the mixture was added to 5 l of 80 % ethanol aqueous solution, extracted three times under reflux, and then dipped at 15 °C for 1 day. Then, the extract was filtered through filter cloth and centrifuged to separate into a residue and a filtrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 260 g of a mixed herbal extract.
  • the honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima Nakai prepared in Preparation Examples 5 and 6, respectively, and Lycium chinense Mill were mixed together at a weight ratio of 3:3:1 to prepare 2 kg of the mixture.
  • the mixture was added to 5 l of 80 % ethanol aqueous solution, extracted three times under reflux, and then dipped at 15 °C for 1 day. Then, the extract was filtered through filter cloth and centrifuged to separate into a residue and a filtrate.The separated filtrate was concentrated under reduced pressure, thus obtaining 335 g of a mixed herbal extract.
  • honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima Nakai prepared in Preparation Examples 5 and 6, respectively, and Paeonia suffruticosa were mixed togetherat a weight ratio of 3:3:1 to prepare 2 kg of the mixture.
  • the mixture was added to 5 l of 80 % ethanol aqueous solution, extracted three times under reflux, and then dipped at 15 °C for 1 day. Then, the extract was filtered through filter cloth and centrifuged to separate into a residue and afiltrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 315 g of a mixed herbal extract.
  • the honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima Nakai prepared in Preparation Examples 5 and 6, respectively, Lycium chinense Mill and Paeonia suffruticosa were mixed together at a weight ratio of 3:3:1:1 to prepare 2 kg of the mixture.
  • the mixture was added to 5 l of 80 % ethanol aqueous solution, extracted three times under reflux, and then dipped at 15 °C for 1 day. Then, the extract was filtered through filter cloth and centrifuged to separate into a residue and a filtrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 248 g of a mixed herbal extract.
  • Test Example 1 Test of antioxidant effect (DPPH test)
  • the DPPH oxidation inhibitory effect of the composition was measured.
  • the synthetic antioxidant Trolox was used as a control.
  • Amethod of evaluating antioxidant activity based on the change in absorbance caused by the reduction of the organic radical DPPH (1,1-diphenyl-2-picrylhydrazyl), in which the antioxidant is oxidized was used.
  • the decrease in absorbance caused by the inhibition of oxidation of DPPH compared to the control was measured, and the concentration at which the absorbance was 50% of the control was defined as the effective antioxidant concentration.
  • the mixtures of Examples 1-4 prepared by mixing the herbal extracts at suitable ratios according to the present invention showed excellent antioxidant effects compared to Preparation Examples 1-11.
  • the mixture of Example 4 prepared by mixing the honey-roasted Adenophora triphylla var. japonica Hara, honey-roasted Angelica tenuissima Nakai, Lycium chinense Mill and Paeonia suffruticosa extracts at a suitable ratio showed the greatest antioxidant effect.
  • the mixture of Example 4 showed very high antioxidant activity compared to the synthetic antioxidant Trolox.
  • plasmids having PPAR ⁇ , PPAR ⁇ / ⁇ and PPAR ⁇ genes downstream of a universal promoter which is expressed in general culture conditions; a plasmid having a PPARs response element (“PPRE") promoter, thatis activated by binding with ligand-bound PPARs, and a firefly luciferase gene reporter downstream of the promoter; and a reference plasmid having a ⁇ -galactosidase gene bound to a universal promoter (Proc. Natl. Acad. Sci. USA, 91 (1994) 7355-7359).
  • PPRE PPARs response element
  • HaCaT cells were seeded into a 24-well plate at a density of 5 x 10 4 cells/well, cultured for 24 hours, and then transiently transfected with the plasmid genes. After 24 hours of culture, the cells were washed with phosphate buffered saline (PBS), and then treated with a specified concentration of 7,3',4'-trihydroxyisoflavone and with a specified concentration of known PPARs ligand (the PPAR ⁇ ligand Wy-14,643 or the PPAR ⁇ ligand troglitazone ("TGZ”)) as a positive control group. As a negative control group, a group treated with ethanol used to dissolve the samples was used. After 24 hours of culture, the cells were washed with PBS, harvested and measured for luciferase activity. The measurement results are shown in Tables 1 ⁇ 2 and FIGS. 1 ⁇ 2.
  • PBS phosphate buffered saline
  • TGZ PPAR ⁇ ligand trogli
  • Table 2 and FIG. 1 show the results obtained by transfecting the HaCaT cells, used in this experiment, with the PPRE promoter/reporter plasmid and the PPAR ⁇ expression plasmid, treating the transfected cells with the medicines and measuring the luciferase activity of the cells.
  • Table 3 and FIG. 2 shows the results obtained by transfecting the cells with both the PPAR ⁇ expression plasmid and the PPRE promoter/reporter plasmid, treating the transfected cells with the medicines and measuring the luciferase activity of the cells.
  • the first column of each of the graphs in FIGS. 1 and 2 shows the luciferase activity of the group treated with ethanol as the negative control group
  • the second column shows the luciferase activity of the positive control group treated with the PPAR ⁇ ligand Wy-14,643 or the PPAR ⁇ ligand troglitazone as the positive control group.
  • the mixtures of Examples 1-4 obtained by mixing the herbal extracts at suitable ratios induced a significantly high degree of PPAR ⁇ and PPAR ⁇ activities compared to Preparation Examples 1-11, and thus showed high liciferase activities compared to Preparation Examples 1-11.
  • the mixture of Example 4 obtained by mixing the honey-roasted Adenophora triphylla var. japonica Hara, honey-roasted Angelica tenuissima Nakai, Lycium chinense Mill and Paeonia suffruticosa extracts at a suitable ratio showed the highest luciferase activity.
  • Test Example 3 Effect of promoting differentiation of keratinocytes
  • the cornified envelopes produced during the differentiation of keratinocytes was measured by absorbance in the following manner.
  • human keratinocytes that had been primarily cultured after isolation from the epidermis of infants were placed in a culture flask and attached to the bottom thereof. Then, the culture solution was treated with 1 ppm of each of the test materials shown in Table 4 below, and the cells were cultured for 5 days to a confluence of about 70-80%.
  • Alow calcium (0.03 mM)-treated group and a low calcium (1.2 mM)-treated group were used as a negative control group and a positivecontrol group, respectively.
  • the harvested cells were harvested, washed with PBS (phosphate buffered saline), and 1 ml of 10 mM Tris-HCl buffer (pH 7.4) containing 2% SDS (sodium dodecyl sulfate) and 20 mM DTT (dithiothreitol) was added thereto. Then, the cells were sonicated, boiled and centrifuged, and the precipitate was suspended in 1 ml of PBS and measured for absorbance at 340 nm. Aportion of the solution obtained after the sonication was taken, and the protein content thereof was measured and used as a reference for evaluating the differentiation of the cells. The test results are shown in Table 4 below.
  • Test Example 4 Measurement of effects of restoring skin barrier function and increasing skin water-holding capacity in hairless mouse skin
  • acetone was applied to the back of 8-10-week-old hairless mice (Charles River, Japan) twice a day for 5 days to induce the loss of skin barrier function in the back of the test animals. Then, the transepidermal water loss (TEWL) of the skin of the test animals was measured with an evaporimeter, and only test animals having skins showing a transepidermal water loss of more than 40 g/m 2 /hr were selected.
  • TEWL transepidermal water loss
  • each of a 7:3 mixture of propylene glycol and ethanol (a vehicle-treated group) and a sample containing 1 wt% of each of Examples 1-4 and Preparation Examples 1-11 was applied in an amount of 200 ⁇ l per 5 cm 2 of sample area twice a day for 3 days, while the TEWL of the skin was measured at given time intervals.
  • the measurement results are shown in Table 5 and FIG. 3.
  • the skin’s water content was measured with Corneometer (Courage Khazaka, Germany), and the measurement results are shown in Table 6 and FIG. 4.
  • the skin’s water content of an untreated group was also measured.
  • Example 4 showed the greatest effect of restoring skin barrier damage.
  • Test Examples 1-4 suggest that the composition of the present invention can promote the formation of keratinocytes, such that the horny layer can exhibit normal skin barrier function, thereby increasing the water-holding capacity of the skin.

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Abstract

L'invention concerne une composition cosmétique contenant, comme principe actif, un mélange d'extraits d'adenophora triphylla var. japonica hara grillée au miel et d'angelica tenuissima nakai grillée au miel, lequel mélange est traité au moyen d'une technique de traitement aux plantes médicinales; et un mélange d'extraits de plantes médicinales, telles que le lyciet de Chine ou la pivoine arbustive. Cette composition présente un excellent pouvoir anti-oxydant et d'hydratation de la peau.
PCT/KR2009/006839 2008-11-19 2009-11-19 Composition cosmétique contenant des extraits d'adenophora triphylla var. japonica hara, d'angelica tenuissima et de plantes médicinales WO2010058986A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/129,932 US9480638B2 (en) 2008-11-19 2009-11-19 Cosmetic composition containing extracts of Adenophora triphylla var. japonica Hara, Angelica tenuissima and medicinal herbs
JP2011536265A JP5577347B2 (ja) 2008-11-19 2009-11-19 沙参、藁本および生薬の抽出物を含む化粧料組成物
CN200980145095.3A CN102209526B (zh) 2008-11-19 2009-11-19 含有日本轮叶沙参、极细当归和药草的提取物的化妆品组合物

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KR10-2008-0115260 2008-11-19
KR20080115260A KR101480696B1 (ko) 2008-11-19 2008-11-19 사삼, 고본 및 생약 추출물을 포함하는 것을 특징으로 하는화장료 조성물

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CN103860645A (zh) * 2014-02-12 2014-06-18 兰赫(上海)生物科技有限公司 一种防止和修复皮肤损伤的组合物
CN108113953A (zh) * 2018-01-08 2018-06-05 植然方适（杭州）健康科技有限公司 一种具有保湿功效的铁皮石斛蜂蜜复合提取物及其制备方法以及在护肤品中的应用
KR102225574B1 (ko) 2018-02-21 2021-03-10 경북대학교 산학협력단 고본추출물을 유효성분으로 포함하는 비만 또는 비만 관련 합병증의 예방, 치료, 또는 개선용 조성물
KR101988830B1 (ko) * 2018-10-22 2019-06-18 주식회사 비바코리아 여성 가슴 확대, 피부 탄력 향상 및 보습용 화장료 조성물

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692208A (en) * 1979-12-27 1981-07-25 Sunstar Inc External preparation for skin whitening
JP3536111B2 (ja) * 1992-06-29 2004-06-07 株式会社ナリス化粧品 ムコ多糖類断片化抑制剤および化粧料
CN1102091A (zh) * 1993-10-28 1995-05-03 贵州天然化妆品厂 一种美容保健品及其制备方法
JPH08283172A (ja) * 1995-04-14 1996-10-29 Kose Corp 活性酸素消去剤及びこれを含有する皮膚外用剤
JPH11228436A (ja) * 1998-02-10 1999-08-24 Pola Chem Ind Inc 生体内物質分布不均一改善剤
JPH11279069A (ja) * 1998-03-27 1999-10-12 Ichimaru Pharcos Co Ltd 活性酸素消去剤
JP2000103718A (ja) * 1998-09-28 2000-04-11 Pola Chem Ind Inc 生体活動改善用の組成物
KR100375916B1 (ko) * 2000-01-11 2003-03-15 충청북도 (관리부서:충청북도 농업기술원) 고본젤리 및 그 제조방법
TWI324933B (en) * 2001-06-27 2010-05-21 Hisamitsu Pharmaceutical Co Sheet-type packs
JP2003026535A (ja) * 2001-07-17 2003-01-29 Tsumura & Co 表皮バリア機能障害抑制剤
JP2003113013A (ja) * 2001-09-28 2003-04-18 Lion Corp 植物性抗菌防腐剤
CN1211066C (zh) * 2001-11-16 2005-07-20 尚悦杰 一种中药面膜
JP2004244382A (ja) * 2003-02-14 2004-09-02 Ichimaru Pharcos Co Ltd 化粧料組成物又は飲食品
KR20060093164A (ko) * 2005-02-21 2006-08-24 주식회사 엘지생활건강 주름완화 화장료 조성물
KR100626398B1 (ko) * 2005-03-11 2006-09-20 박선호 흡연자 및 흡연경력자를 위한 항산화영양소 보충 조성물 및그 제조방법
CN101062002B (zh) * 2006-04-24 2010-06-16 王筑平 含植物提取物的护肤组合物
JP2008169196A (ja) * 2006-10-31 2008-07-24 Arura Tibetan Medical Center 皮膚外用剤
KR101483440B1 (ko) * 2008-05-02 2015-01-19 (주)아모레퍼시픽 포제를 활용한 약용식물 추출물 및 이를 함유하는 피부외용제 조성물
KR101480695B1 (ko) * 2008-06-10 2015-01-12 (주)아모레퍼시픽 포제를 활용한 황금 추출물을 함유하는 화장료 조성물
KR101537293B1 (ko) * 2008-11-19 2015-07-16 (주)아모레퍼시픽 포제 처리된 감국 또는 진피 추출물을 함유하는 항산화용 화장료 조성물

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KR20100056200A (ko) 2010-05-27
US9480638B2 (en) 2016-11-01
JP5577347B2 (ja) 2014-08-20
KR101480696B1 (ko) 2015-01-09
CN102209526A (zh) 2011-10-05
JP2012509256A (ja) 2012-04-19
WO2010058986A3 (fr) 2010-09-30
US20110223268A1 (en) 2011-09-15

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