JP3908245B2 - 養毛剤 - Google Patents
養毛剤 Download PDFInfo
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- JP3908245B2 JP3908245B2 JP2004230808A JP2004230808A JP3908245B2 JP 3908245 B2 JP3908245 B2 JP 3908245B2 JP 2004230808 A JP2004230808 A JP 2004230808A JP 2004230808 A JP2004230808 A JP 2004230808A JP 3908245 B2 JP3908245 B2 JP 3908245B2
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- hair
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- kusunohagashi
- kobatei
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Description
(実施例1)
本実施例の養毛剤は、クスノハガシワ(Mallotus philippinensis Mueller-Argoviensis)の樹皮の抽出成分からなるものである。その1つの製造例について説明すると、クスノハガシワ(Mallotus philippinensis Mueller-Argoviensis)の樹皮(乾燥物)200gを2L の50%エタノールに浸漬し、60〜80℃で2日間抽出し、抽出液から溶媒を除去し、5.3gの抽出物を得た。
本実施例の養毛剤は、コバテイシ(Terminalia sericea Bunch. L)の根の抽出成分からなるものである。その1つの製造例について説明すると、コバテイシ(Terminalia sericea Bunch. L)の根(乾燥物)200gを2L の50%エタノールに浸漬し、60〜80℃で2日間抽出し、抽出液から溶媒を除去し、9.5gの抽出物を得た。
ヒト毛乳頭細胞を12wellプレートに2×104 / well で播種し、10%牛胎児血清を添加したダルベッコ変法MEM培地(DMEM培地)で5日間培養した。培養5日目にDMEM培地で細胞を洗浄後、各濃度(0.00001重量%、0.0001重量%、0.001重量%)のクスノハガシワ抽出物又はコバテイシ抽出物を含むDMEM培地を加え、さらに培養を続けた。
ヒト毛乳頭細胞を12wellプレートに2×104 / well で播種し、10%牛胎児血清を添加したダルベッコ変法MEM培地(DMEM培地)で5日間培養した。培養5日目にDMEM培地で細胞を洗浄後、各濃度(0.00001重量%、0.0001重量%、0.001重量%)のクスノハガシワ抽出物又はコバテイシ抽出物を含むDMEM培地を加え、さらに培養を続けた。
C3H/Heマウス(8週齢、雄)の背部を剃毛し、1日に1回、0.1重量%のクスノハガシワ抽出物あるいはコバテイシ抽出物を含む50%エタノール溶液を0.1mlずつ、15日間塗布した。一方、抽出物を含まない50%エタノール溶液を、同様にC3H/Heマウスの背部に1日に1回塗布し、これを対照群とした。クスノハガシワ抽出物およびコバテイシ抽出物の毛成長促進効果は、剃毛後15日目における剃毛部の毛再生面積率を比較することにより調べた。その結果を表5に示す。
本処方例は、ヘアークリームの処方例であり、その組成は次のとおりである。
配合成分 重量%
精製ラノリン 4.0
流動パラフィン 40.0
モノステアリン酸ポリオキシエチレンソルビタン 4.0
モノステアリン酸ソルビタン 1.5
モノステアリン酸グリセリン 2.0
パラオキシ安息香酸メチル 0.1
セタノール 2.0
エデト酸四ナトリウム 0.1
クスノハガシワ抽出物 0.1
1,3−ブチレングリコール 4.0
ラウリル硫酸トリエタノールアミン 1.0
香料 0.1
精製水 残量
本処方例は、ヘアローションの処方例であり、その組成は次のとおりである。
配合成分 重量%
酢酸−dl−α−トコフェロール 0.05
グリチルリチン酸ジカリウム 0.1
l−メントール 0.1
クスノハガシワ抽出物 0.1
香料 0.1
パラオキシ安息香酸メチル 0.1
ジプロピレングリコール 3.0
エタノール 60.0
精製水 残量
本処方例は、ヘアローションの処方例であり、その組成は次のとおりである。
配合成分 重量%
酢酸−dl−α−トコフェロール 0.05
グリチルリチン酸ジカリウム 0.1
l−メントール 0.1
コバテイシ抽出物 0.1
香料 0.1
パラオキシ安息香酸メチル 0.1
ジプロピレングリコール 3.0
エタノール 60.0
精製水 残量
Claims (2)
- クスノハガシワの樹皮から抽出した抽出物を有効成分として含有することを特徴とする養毛剤。
- クスノハガシワの樹皮から抽出した抽出物を有効成分として含有することを特徴とするTGF−β産生抑制養毛剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004230808A JP3908245B2 (ja) | 2004-08-06 | 2004-08-06 | 養毛剤 |
Applications Claiming Priority (1)
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