WO2021017149A1 - 高密闭制粒、干燥、混合一体机 - Google Patents

高密闭制粒、干燥、混合一体机 Download PDF

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Publication number
WO2021017149A1
WO2021017149A1 PCT/CN2019/108909 CN2019108909W WO2021017149A1 WO 2021017149 A1 WO2021017149 A1 WO 2021017149A1 CN 2019108909 W CN2019108909 W CN 2019108909W WO 2021017149 A1 WO2021017149 A1 WO 2021017149A1
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WO
WIPO (PCT)
Prior art keywords
air inlet
granulator
buffer tank
mixing
valve
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Application number
PCT/CN2019/108909
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English (en)
French (fr)
Inventor
方正
戴华锋
连朋生
吴国桥
吴武通
李挺
Original Assignee
浙江迦南科技股份有限公司
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Application filed by 浙江迦南科技股份有限公司 filed Critical 浙江迦南科技股份有限公司
Publication of WO2021017149A1 publication Critical patent/WO2021017149A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/02—Cleaning by the force of jets or sprays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08—Cleaning containers, e.g. tanks
    • B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
    • B08B9/28—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking

Definitions

  • the invention relates to the technical field of powder granulation, in particular to a high-sealed granulation, drying and mixing integrated machine.
  • the wet mixing granulation process includes granulation, drying, granulation and mixing.
  • a wet granulator, a wet granulator, a one-step granulator, a dry granulator and a mixer are usually required to complete the process.
  • these devices are in continuous production work, due to the transfer of drugs in the intermediate process, there is a risk of drug contamination, which reduces the reliability of drug production.
  • the present invention provides a highly airtight granulation, drying and mixing integrated machine, which has good airtightness and improves the production and processing effect.
  • the invention provides a highly airtight granulating, drying and mixing integrated machine, comprising a frame on which a wet granulator, a wet granulator, a one-step granulator, a dry granulator, a buffer tank, Lift the mixer and the barrel, the wet granulator is arranged below the wet granulator and connected with the discharge port of the wet granulator, the one-step granulator is arranged on the side of the wet granulator, and the one-step granulator
  • the feed port of the granulator is connected with the discharge port of the wet granulator, the dry granulator is arranged under the one-step granulator and connected with the discharge port of the one-step granulator, and the buffer tank is arranged in the other of the one-step granulator.
  • One side is connected with the discharge port of the dry granulator, characterized in that: the barrel is arranged below the buffer tank, the lifting mixer is movably arranged between the barrel and the buffer tank, and the frame outer cover is provided with
  • the sealed isolation bin forms the isolation of the rack from the outside.
  • the sealed isolation bin is provided with isolation operation windows corresponding to each position of the rack, the isolation operation windows are provided with operating gloves, and the sealed isolation bin corresponds to wet granulation
  • the machine position is also provided with an RPT storage tank, the RPT storage tank is connected to the sealed isolation tank through the RPT isolation valve to realize the transfer of materials, and the sealed isolation tank is also provided for forming a negative load in the one-step granulator and the buffer tank.
  • An exhaust device for receiving materials in a compressed environment, and an exhaust filter is provided on the exhaust device.
  • the outer surface of the sealed isolation silo can be designed with a wet granulation sealing door, a dry granulation sealing door, a whole granulation sealing door, a mixed sealing door, and a discharge
  • the warehouse door is sealed, and the equipment is opened before the production process, such as replacing parts and components through the opening of the warehouse door.
  • an inflatable sealing ring will be used to seal the warehouse door and the warehouse wall with pressure detection.
  • the warehouse door is locked as an automatic lock and it is not allowed to open the warehouse door abnormally.
  • the warehouse door is provided with an operating port and equipped with operating gloves. During the process of equipment production, the operator can operate each functional machine through the operating gloves.
  • RTP isolation valve and RPT storage tank used for material transfer in the equipment process production process.
  • Such as tools, garbage in the isolator, forgotten APIs, etc. Add the prepared materials into the wet granulator through operating gloves.
  • the wet granulator is equipped with a pressure transmitter on the cylinder head, so that the exhaust in the wet granulator can be connected to the exhaust device to achieve centralized discharge; after the wet granulator finishes its work, the wet discharge door opens, The wet granules are discharged into the wet granulator by gravity.
  • the wet granules processed by the wet granulator enter the one-step granulator due to the negative pressure generated by the exhaust device.
  • the wet granulator and the one-step granulator are preferably connected by a vacuum pipe, which is cleaner.
  • the material is discharged to the dry granulator through the flap discharge valve.
  • the dry granulator completes the granulation, it enters the buffer tank due to the negative pressure generated by the exhaust device, and the dry granulator and the buffer tank are preferably connected by a vacuum pipeline, which is cleaner.
  • the lifting mixer is set up between the barrel and the buffer tank. Through the activity, the material from the buffer tank can be received. After turning and mixing, it is sent to the barrel to complete a series of processing actions.
  • the device realizes a closed condition
  • the following granulation process has a simple structure, which is conducive to realization and better processing and production effects.
  • the lifting mixer includes a mixing hopper and a mounting seat
  • the mounting seat is provided with a fixed ring and a driving cylinder for driving the fixed ring to slide
  • the mixing hopper is fixedly connected to the fixed ring
  • a driving seat is provided on the frame corresponding to the position of the lifting mixer, and a driving motor is provided on the driving seat. The output end of the driving motor is drivingly connected with the mounting seat to drive the rotation of the mounting seat.
  • the beneficial effect of this arrangement is: adopting the above solution, the mounting seat is driven to rotate by the drive motor, so as to realize the operation of the mixing turnover action.
  • the mixing hopper is pushed by the driving cylinder, so that the fixed ring realizes the The slip between the barrel and the buffer tank realizes the docking and separation actions, thereby realizing the transfer of materials.
  • This structure is simple and easy to realize. It does not require manual transfer of materials, reduces the possibility of pollution, and improves the sealing level.
  • a positioning seat is provided between the lifting mixer and the buffer tank, the buffer tank is fixedly arranged on the positioning seat, the positioning seat is provided with a first ⁇ active valve, and the buffer tank is discharged
  • the port is fixedly connected with the first ⁇ active valve
  • the opening position of the mixing hopper is provided with an ⁇ passive valve
  • the ⁇ passive valve is connected with the first ⁇ active valve to form a communication between the buffer tank and the mixing hopper
  • the barrel opening is provided
  • the beneficial effect of this arrangement is that the above-mentioned scheme and the use of this docking method have a simple structure, which is conducive to realization, and at the same time has a good sealing effect and improves the use effect of the equipment.
  • a vertical positioning device is further provided on the frame, the vertical positioning device includes an induction probe and a positioning piece, the two induction probes are arranged on the rotation track of the mixing hopper, and the two induction probes are arranged oppositely
  • the positioning piece is arranged on the mixing hopper, and the positioning piece is shielded between the two sensing probes to form the positioning of the mixing hopper in a vertical position.
  • the beneficial effect of this arrangement is: with the above solution, the two sensing probes emit sensing light or infrared rays, and when the positioning sheet is vertical to the mixing hopper, it can be just shielded between the two sensing probes, so that the position of the hopper can be judged and subsequent lifting can be carried out.
  • the ⁇ passive valve is connected with the first ⁇ active valve or the second ⁇ active valve.
  • an air inlet device is further provided on the sealed isolation bin, the air inlet device includes an air inlet pipeline, an air inlet fan, an air inlet butterfly valve and an air inlet filter, and the air inlet fan is arranged at the inlet
  • the air inlet butterfly valve is placed in the air pipeline and is installed in front of the air inlet butterfly valve.
  • the air inlet butterfly valve is installed at the position of the air inlet of the air inlet pipeline, and the air inlet filter is arranged at the corresponding position of the air inlet of the air inlet pipeline and placed at the air inlet
  • the air inlet filter includes multiple layers of filter screens arranged at intervals.
  • the beneficial effect of such a configuration is: adopting the above-mentioned scheme and such a design, the equipment can be air-intaken through the air inlet device, and the filter screen can make the air quality of the internal pipeline meet the cleanliness level required by GMP, and the structure Simple and easy to achieve.
  • the air inlet filter further includes a pipeline heater, and the pipeline heater is arranged on the air inlet pipeline to heat the inlet air.
  • the beneficial effect of this arrangement is that with the above solution, heating can achieve further sterilization, and at the same time, the temperature of the space entering the sealed isolation bin can be changed, and the isolation bin can be kept at a proper temperature without major fluctuations.
  • the present invention is further provided that a cleaning spray gun is provided at a position of the sealed isolation bin near the operating gloves, a drain port is provided at the bottom of the sealed isolation bin, and a drain valve is provided on the drain port.
  • the beneficial effect of this arrangement is that by adopting the above solution, a cleaning spray gun is set in the isolation bin, and the interior can be cleaned when the isolation bin is closed. After the entire production process is completed, the manual cleaning spray gun can be operated by operating gloves to clean the barrel. Wait for the equipment to be flushed, and then transfer after flushing. At the same time, the cleaned sewage can be discharged through the drain.
  • This structure is simple, avoids opening the isolation and sealed bin for cleaning, reduces the possibility of external dirt entering the isolation bin, and ensures the use of the equipment. And efficiency.
  • FIG. 1 is a schematic diagram of the front structure of an embodiment of the present invention
  • Figure 2 is a schematic side view of an embodiment of the present invention.
  • Figure 3 is a schematic top view of the structure of an embodiment of the present invention.
  • Figure 4 is a top view of the lifting mixer in an embodiment of the invention.
  • Figure 5 is a side view of the lifting mixer in the embodiment of the present invention.
  • this embodiment discloses a highly enclosed granulation, drying, and mixing integrated machine, including a frame on which a wet granulator 2 and a wet granulator are arranged. 3.
  • the one-step granulator 4 the dry granulator 5, the buffer tank 6, the lifting mixer 7 and the barrel 8.
  • the wet granulator 3 is arranged under the wet granulator 2 and is connected to the wet granulator 2.
  • the feed port is connected, the one-step granulator 4 is arranged on the side of the wet granulator 2, the feed port of the one-step granulator 4 is connected with the discharge port of the wet granulator 3, and the dry granulator 5 is set Below the one-step granulator 4 and connected to the outlet of the one-step granulator 4, the buffer tank 6 is arranged on the other side of the one-step granulator 4 and connected with the outlet of the dry granulator 5, the barrel 8 is arranged under the buffer tank 6, the lifting mixer 7 is movably arranged between the barrel 8 and the buffer tank 6, and the frame outer cover is provided with a sealed isolation bin 1 to isolate the frame from the outside.
  • the isolation bin 1 is provided with isolation operation windows 12 at each position corresponding to the frame, the isolation operation windows 12 are provided with operating gloves, and the sealed isolation bin 1 is also provided with an RPT storage barrel 11 at a position corresponding to the wet granulator 2
  • the RPT storage barrel 11 is connected to the sealed isolation bin 1 through the RPT isolation valve to realize the transfer of materials.
  • the sealed isolation bin 1 is also provided with a negative pressure environment for the one-step granulator 4 and the buffer tank 6 to receive
  • the material exhaust device 13 is provided with an exhaust filter.
  • the outer surface of the sealed isolation bin 1 can be designed with a wet granulation sealed bin door, a dry granulation sealed bin door, a whole granulation sealed bin door, a mixed sealed bin door,
  • the material seals the warehouse door, and before the equipment performs process production, the pre-production preparations such as replacement of parts through the opening of the warehouse door.
  • an inflatable sealing ring is used to seal the warehouse door and the warehouse wall with pressure detection.
  • the warehouse door is locked as an automatic lock, and abnormal opening of the warehouse door is not allowed.
  • the warehouse door is equipped with an operating port and equipped with operating gloves. During the process of equipment production, the operator can operate each functional machine through the operating gloves.
  • the RTP isolation valve and the RPT storage tank 11 are further designed for material transfer in the equipment process. Such as tools, garbage in the isolator, and forgotten APIs.
  • the prepared materials are added to the wet granulator 2 through operating gloves.
  • the wet granulator 2 is designed with a pressure transmitter on the cylinder head, so that the exhaust in the wet granulator 2 can be connected to the exhaust device 13 to achieve centralized discharge; after the wet granulator 2 finishes its work, the wet discharge The material door is opened, and the wet particles are discharged into the wet granulator 3 by gravity.
  • the wet granules processed by the wet granulator 3 enter the one-step granulator 4 due to the negative pressure generated by the exhaust device 13, where the wet granulator 3 and the one-step granulator 4 are preferably connected by a vacuum pipe, Cleaner.
  • the material is discharged to the dry granulator 5 through the turning plate discharge valve.
  • the dry granulator 5 completes granulation, it enters the buffer tank 6 due to the negative pressure generated by the exhaust device 13, and the dry granulator 5 and the buffer tank 6 are preferably connected by a vacuum pipe, which is cleaner.
  • the lifting mixer 7 is movably set between the barrel 8 and the buffer tank 6, and can receive materials from the buffer tank 6 through activities. After turning and mixing, it is sent to the barrel 8 to complete a series of processing actions.
  • the granulation process under the closed condition is realized, and the structure is simple, which is conducive to realization and the processing and production effect is better.
  • the above-mentioned lifting mixer 7 includes a mixing hopper 71 and a mounting seat 91.
  • the mounting seat 91 is provided with a fixed ring 72 and a driving cylinder 92 for driving the fixed ring 72 to slide.
  • the mixing hopper 71 is fixedly connected to the fixed ring 72
  • a driving seat is provided on the frame corresponding to the position of the lifting mixer 7, and a driving motor 9 is provided on the driving seat.
  • the output end of the driving motor 9 is drivingly connected with the mounting seat 91 to drive the mounting seat 91 to rotate.
  • the beneficial effect of this arrangement is that the above-mentioned solution is adopted to drive the mounting seat 91 to rotate through the drive motor 9 to realize the operation of the mixing turnover action.
  • the mixing hopper 71 When materials need to be received or released, the mixing hopper 71 is moved by driving the air cylinder 92 to make it fixed
  • the ring 72 realizes the slippage between the barrel 8 and the buffer tank 6, and realizes the docking and disengagement actions, thereby realizing the transfer of materials.
  • This structure is simple and easy to realize. It does not require manual transfer of materials and reduces the possibility of pollution , Improve the airtight level.
  • a positioning seat is provided between the lifting mixer 7 and the buffer tank 6, the buffer tank 6 is fixedly arranged on the positioning seat, the first ⁇ active valve is provided on the positioning seat, and the discharge port of the buffer tank 6 is connected with
  • the first ⁇ active valve is fixedly connected, the opening position of the mixing hopper 71 is provided with an ⁇ passive valve 72, and the ⁇ passive valve 72 is connected with the first ⁇ active valve to form a communication between the buffer tank 6 and the mixing hopper 71.
  • a second ⁇ active valve is provided at the opening 8, and the second ⁇ active valve is connected with the ⁇ passive valve 72 to form a communication between the mixing hopper 71 and the barrel 8.
  • the above-mentioned frame is also provided with a vertical positioning device.
  • the vertical positioning device includes an induction probe and a positioning piece.
  • the two induction probes are arranged on the rotation track of the mixing hopper 71.
  • the two induction probes are arranged opposite to each other. It is arranged on the mixing hopper 71, and the positioning sheet is shielded between the two sensing probes to form the vertical positioning of the mixing hopper 71.
  • the beneficial effect of this arrangement is: with the above solution, the two sensing probes emit sensing light or infrared rays, and when the positioning sheet is vertical to the mixing hopper 71, it can be just shielded between the two sensing probes, so that the position of the hopper can be judged and the follow-up
  • the lifting enables the ⁇ passive valve 72 to be connected with the first ⁇ active valve or the second ⁇ active valve. This structure is simple and facilitates realization, ensures the accuracy of positioning, and improves the use effect of the equipment.
  • the above-mentioned sealed isolation bin 1 is also provided with an air inlet device, the air inlet device includes an air inlet pipe, an air inlet fan, an air inlet butterfly valve and an air inlet filter, the air inlet fan is arranged in the air inlet pipe and
  • the air inlet butterfly valve is installed in the front, the air inlet butterfly valve is installed at the position of the air inlet of the air inlet pipe, and the air inlet filter is arranged at the corresponding position of the air inlet of the air inlet pipe and is placed on the air inlet butterfly valve behind.
  • the wind filter includes a multi-layer filter screen arranged at intervals.
  • the beneficial effect of such a configuration is: adopting the above-mentioned scheme and such a design, the equipment can be air-intaken through the air inlet device, and the filter screen can make the air quality of the internal pipeline meet the cleanliness level required by GMP, and the structure Simple and easy to achieve.
  • the above-mentioned air inlet filter further includes a pipeline heater which is arranged on the air inlet pipeline to heat the inlet air.
  • a pipeline heater which is arranged on the air inlet pipeline to heat the inlet air.
  • the above-mentioned sealed isolation bin 1 is provided with a cleaning spray gun at a position close to the operating gloves, the bottom of the sealed isolation bin 1 is provided with a drain port, and a drain valve is provided on the drain port.
  • a cleaning spray gun is set in the isolation bin, and the interior can be cleaned when the isolation bin is closed.
  • the manual cleaning spray gun can be operated by operating gloves to clean the barrel. Wait for the equipment to be flushed, and then transfer after flushing. At the same time, the cleaned sewage can be discharged through the drain.
  • This structure is simple, avoids opening the isolation and sealed bin for cleaning, reduces the possibility of external dirt entering the isolation bin, and ensures the use of the equipment. And efficiency.

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Drying Of Solid Materials (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)

Abstract

一种高密闭制粒、干燥、混合一体机，包括机架，所述机架上设置有湿法制粒机(2)、湿整粒机(3)、一步制粒机(4)、干整粒机(5)、缓存罐(6)、提升混合机(7)和料筒(8)，所述提升混合机(7)活动设置在料筒(8)和缓存罐(6)之间，所述机架外罩设有密封隔离仓(1)形成对机架与外界的隔离，所述密封隔离仓(1)上对应机架各位置设置有隔离操作窗(12)，所述隔离操作窗(12)上设置有操作手套，所述密封隔离仓(1)上还设置有用于在一步制粒机(4)以及缓存罐(6)形成负压环境从而接收物料的排风装置(13)，所述排风装置(13)上设置有排风过滤器。其具有良好的密闭性，提高生产加工效果。

Description

高密闭制粒、干燥、混合一体机 技术领域
本发明涉及粉末制粒技术领域，尤其是一种高密闭制粒、干燥、混合一体机。
 背景技术
湿法混合制粒过程包括制粒、干燥、整粒和混合工作，为了完成上述工序通常需要湿法制粒机、湿法整粒机、一步制粒机、干整粒机和混合机来进行完成，但是这些设备在连续性的生产工作时，由于中间过程存在药物的转运，使得药物存在污染的风险，降低药物生产的可靠性。
 技术问题
针对现有技术的不足，本发明提供一种高密闭制粒、干燥、混合一体机，其具有良好的密闭性，提高生产加工效果。
 技术解决方案
本发明提供一种高密闭制粒、干燥、混合一体机，包括机架，所述机架上设置有湿法制粒机、湿整粒机、一步制粒机、干整粒机、缓存罐、提升混合机和料筒，所述湿整粒机设置在湿法制粒机下方并与湿法制粒机出料口连接，所述一步制粒机设置在湿法制粒机一侧，所述一步制粒机进料口与湿整粒机出料口连接，所述干整粒机设置在一步制粒机下方并与一步制粒机出料口连接，所述缓存罐设置在一步制粒机另一侧并与干整粒机出料口连接，其特征在于：所述料筒设置在缓存罐下方，所述提升混合机活动设置在料筒和缓存罐之间，所述机架外罩设有密封隔离仓形成对机架与外界的隔离，所述密封隔离仓上对应机架各位置设置有隔离操作窗，所述隔离操作窗上设置有操作手套，所述密封隔离仓上对应湿法制粒机位置还设置有RPT储料桶，所述RPT储料桶通过RPT隔离阀与密封隔离仓连接实现物料的传递，所述密封隔离仓上还设置有用于在一步制粒机以及缓存罐形成负压环境从而接收物料的排风装置，所述排风装置上设置有排风过滤器。
 有益效果
这样设置的有益效果是：设置成这种形式，密封隔离仓外表面可以设计有湿法制粒密封仓门、干燥制粒密封仓门、整粒制粒密封仓门、混合密封仓门、出料密封仓门，设备进行工艺生产前，通过仓门的开启更换零部件等生产前的准备工作。仓门关闭设备工艺生产开始后，作为优选仓门与仓壁之间会采用充气密封圈密封并带有压力检测，仓门锁定为自动锁，不允许非正常开仓门。仓门上开设有操作口并配置操作手套，设备进行工艺生产过程中，操作人员可以通过操作手套对各功能机进行操作。进一步的设计有RTP隔离阀和RPT储料桶，用于在设备工艺生产过程的物料传递。比如工具、隔离器内垃圾、遗忘的API等。通过操作手套将准备好的物料加入到湿法制粒机内。湿法制粒机在缸盖上设计压力变送器，使得湿法制粒机中的排气可以连接在排风装置上，实现集中排放；湿法制粒机完成工作后，湿法出料门打开，湿颗粒通过重力出料到湿整粒机中。经湿整粒机处理后的湿颗粒，因排风装置产生的负压而进入一步制粒机，这里湿整粒机与一步制粒机之间作为优选通过真空管道连接，更为洁净。一步制粒机完成工艺后，通过翻板出料阀出料到干整粒机。干整粒机完成整粒后，因排风装置产生的负压而进入缓存罐，干整粒机与缓存罐之间作为优选通过真空管道连接，更为洁净。提升混合机活动设置在料筒和缓存罐之间，通过活动可以接受来自缓存罐中的物料，再进行翻转混合后，送入料筒，完成一系列的加工动作，该装置实现有在密闭条件下的制粒过程，同时结构简单，利于实现，加工生产效果更好。
本发明进一步设置为所述提升混合机包括混合料斗和安装座，所述安装座上设置有固定环和用于驱动固定环滑移的驱动气缸，所述混合料斗与固定环固定连接，所述机架上对应提升混合机位置设置有驱动座，所述驱动座上设置有驱动电机，所述驱动电机输出端与安装座传动连接形成对安装座转动的驱动。
这样设置的有益效果是：采用上述方案，通过驱动电机带动安装座转动，从而实现对混料翻转动作的操作，在需要接收或释放物料时，通过驱动气缸推移混合料斗，使得固定环实现在料筒和缓存罐之间的滑移，实现对接和脱离动作，从而实现物料的传递，这种结构简单，利于实现，不需要人工手动转移物料，降低了污染的可能性，提高了密闭等级。
本发明进一步设置为所述提升混合机与缓存罐之间设置有定位座，所述缓存罐固定设置在定位座上，所述定位座上设置有第一αβ主动阀，所述缓存罐出料口与第一αβ主动阀固定连接，所述混合料斗开口位置设置有αβ被动阀，所述αβ被动阀与第一αβ主动阀连接形成缓存罐与混合料斗的连通，所述料筒开口处设置有第二αβ主动阀，所述第二αβ主动阀与αβ被动阀连接形成混合料斗与料筒的连通。
这样设置的有益效果是，采用上述方案，采用这种对接方式，结构简单，利于实现，同时具有良好的密封效果，提高设备的使用效果。
本发明进一步设置为所述机架上还设置有垂直定位装置，所述垂直定位装置包括感应探头和定位片，所述感应探头为两个并设置在混合料斗转动轨迹上，两感应探头相对设置，所述定位片设置在混合料斗上，所述所述定位片遮挡在两感应探头之间形成混合料斗在垂直位置的定位。
这样设置的有益效果是：采用上述方案，两个感应探头射出感应光或者红外线，定位片在混合料斗垂直时，可以正好遮挡在两个感应探头之间，从而可以判断料斗位置，进行后续的升降使αβ被动阀与第一αβ主动阀或第二αβ主动阀接通，这种结构简单，利于实现，保证定位的准确性，提高设备的使用效果。
本发明进一步设置为所述密封隔离仓上还设置有进风装置，所述进风装置包括进风管路、进风风机、进风蝶阀和进风过滤器，所述进风风机设置在进风管路内并前置于进风蝶阀，所述进风蝶阀安装在进风管路进风口位置上，所述进风过滤器设置在进风管路进风口对应位置并后置于进风蝶阀，所述进风过滤器包括多层间隔设置的过滤网。
这样设置的有益效果是：采用上述方案，这样设计，通过进风装置可以使设备的进风，并且具有过滤网，可以使得内部管路的补气的空气质量符合GMP要求的洁净等级，同时结构简单，利于实现。
本发明进一步设置为所述进风过滤器还包括管路加热器，所述管路加热器设置在进风管路上实现对进风空气的加热。
这样设置的有益效果是，采用上述方案，加热可以起到进一步杀菌的同时，可以改变进入密封隔离仓空间温度，保持隔离仓中处于一个合适的温度，不会出现较大的波动。
本发明进一步设置为所述密封隔离仓靠近操作手套位置设置有清洗喷枪，所述密封隔离仓底部设置有排水口，所述排水口上设置有排水阀。
这样设置的有益效果是，采用上述方案，在隔离仓内设置清洗喷枪，可以在隔离仓封闭的情况下，对内部进行清洗，整个生产工艺完成后，人工可以通过操作手套操作清洗喷枪对料桶等设备进行冲洗，冲洗后再进行转移，同时清洗后的污水可以通过排水口排出，这种结构简单，避免开启隔离密封仓进行清洗，减少外界污物进入隔离仓的可能，保证设备的使用效果和使用效率。
 附图说明
图1为本发明实施例的正面结构示意图；
图2为本发明实施例的侧面结构示意图；
图3为本发明实施例的俯视结构示意图；
图4为本发明实施例中提升混合机的俯视图；
图5为本发明实施例中提升混合机的侧面视图。
 本发明的最佳实施方式
由图1至图5可以看出，该实施方式公开了一种高密闭制粒、干燥、混合一体机，包括包括机架，所述机架上设置有湿法制粒机2、湿整粒机3、一步制粒机4、干整粒机5、缓存罐6、提升混合机7和料筒8，所述湿整粒机3设置在湿法制粒机2下方并与湿法制粒机2出料口连接，所述一步制粒机4设置在湿法制粒机2一侧，所述一步制粒机4进料口与湿整粒机3出料口连接，所述干整粒机5设置在一步制粒机4下方并与一步制粒机4出料口连接，所述缓存罐6设置在一步制粒机4另一侧并与干整粒机5出料口连接，所述料筒8设置在缓存罐6下方，所述提升混合机7活动设置在料筒8和缓存罐6之间，所述机架外罩设有密封隔离仓1形成对机架与外界的隔离，所述密封隔离仓1上对应机架各位置设置有隔离操作窗12，所述隔离操作窗12上设置有操作手套，所述密封隔离仓1上对应湿法制粒机2位置还设置有RPT储料桶11，所述RPT储料桶11通过RPT隔离阀与密封隔离仓1连接实现物料的传递，所述密封隔离仓1上还设置有用于在一步制粒机4以及缓存罐6形成负压环境从而接收物料的排风装置13，所述排风装置13上设置有排风过滤器。这样设置的有益效果是：设置成这种形式，密封隔离仓1外表面可以设计有湿法制粒密封仓门、干燥制粒密封仓门、整粒制粒密封仓门、混合密封仓门、出料密封仓门，设备进行工艺生产前，通过仓门的开启更换零部件等生产前的准备工作。仓门关闭设备工艺生产开始后，作为优选仓门与仓壁之间会采用充气密封圈密封并带有压力检测，仓门锁定为自动锁，不允许非正常开仓门。仓门上开设有操作口并配置操作手套，设备进行工艺生产过程中，操作人员可以通过操作手套对各功能机进行操作。进一步的设计有RTP隔离阀和RPT储料桶11，用于在设备工艺生产过程的物料传递。比如工具、隔离器内垃圾、遗忘的API等。通过操作手套将准备好的物料加入到湿法制粒机2内。湿法制粒机2在缸盖上设计压力变送器，使得湿法制粒机2中的排气可以连接在排风装置13上，实现集中排放；湿法制粒机2完成工作后，湿法出料门打开，湿颗粒通过重力出料到湿整粒机3中。经湿整粒机3处理后的湿颗粒，因排风装置13产生的负压而进入一步制粒机4，这里湿整粒机3与一步制粒机4之间作为优选通过真空管道连接，更为洁净。一步制粒机4完成工艺后，通过翻板出料阀出料到干整粒机5。干整粒机5完成整粒后，因排风装置13产生的负压而进入缓存罐6，干整粒机5与缓存罐6之间作为优选通过真空管道连接，更为洁净。提升混合机7活动设置在料筒8和缓存罐6之间，通过活动可以接受来自缓存罐6中的物料，再进行翻转混合后，送入料筒8，完成一系列的加工动作，该装置实现有在密闭条件下的制粒过程，同时结构简单，利于实现，加工生产效果更好。
上述提升混合机7包括混合料斗71和安装座91，所述安装座91上设置有固定环72和用于驱动固定环72滑移的驱动气缸92，所述混合料斗71与固定环72固定连接，所述机架上对应提升混合机7位置设置有驱动座，所述驱动座上设置有驱动电机9，所述驱动电机9输出端与安装座91传动连接形成对安装座91转动的驱动。这样设置的有益效果是：采用上述方案，通过驱动电机9带动安装座91转动，从而实现对混料翻转动作的操作，在需要接收或释放物料时，通过驱动气缸92推移混合料斗71，使得固定环72实现在料筒8和缓存罐6之间的滑移，实现对接和脱离动作，从而实现物料的传递，这种结构简单，利于实现，不需要人工手动转移物料，降低了污染的可能性，提高了密闭等级。
上述提升混合机7与缓存罐6之间设置有定位座，所述缓存罐6固定设置在定位座上，所述定位座上设置有第一αβ主动阀，所述缓存罐6出料口与第一αβ主动阀固定连接，所述混合料斗71开口位置设置有αβ被动阀72，所述αβ被动阀72与第一αβ主动阀连接形成缓存罐6与混合料斗71的连通，所述料筒8开口处设置有第二αβ主动阀，所述第二αβ主动阀与αβ被动阀72连接形成混合料斗71与料筒8的连通。这样设置的有益效果是，采用上述方案，采用这种对接方式，结构简单，利于实现，同时具有良好的密封效果，提高设备的使用效果。
上述机架上还设置有垂直定位装置，所述垂直定位装置包括感应探头和定位片，所述感应探头为两个并设置在混合料斗71转动轨迹上，两感应探头相对设置，所述定位片设置在混合料斗71上，所述所述定位片遮挡在两感应探头之间形成混合料斗71在垂直位置的定位。这样设置的有益效果是：采用上述方案，两个感应探头射出感应光或者红外线，定位片在混合料斗71垂直时，可以正好遮挡在两个感应探头之间，从而可以判断料斗位置，进行后续的升降使αβ被动阀72与第一αβ主动阀或第二αβ主动阀接通，这种结构简单，利于实现，保证定位的准确性，提高设备的使用效果。
上述密封隔离仓1上还设置有进风装置，所述进风装置包括进风管路、进风风机、进风蝶阀和进风过滤器，所述进风风机设置在进风管路内并前置于进风蝶阀，所述进风蝶阀安装在进风管路进风口位置上，所述进风过滤器设置在进风管路进风口对应位置并后置于进风蝶阀，所述进风过滤器包括多层间隔设置的过滤网。这样设置的有益效果是：采用上述方案，这样设计，通过进风装置可以使设备的进风，并且具有过滤网，可以使得内部管路的补气的空气质量符合GMP要求的洁净等级，同时结构简单，利于实现。
上述进风过滤器还包括管路加热器，所述管路加热器设置在进风管路上实现对进风空气的加热。这样设置的有益效果是，采用上述方案，加热可以起到进一步杀菌的同时，可以改变进入密封隔离仓1空间温度，保持隔离仓中处于一个合适的温度，不会出现较大的波动。
上述密封隔离仓1靠近操作手套位置设置有清洗喷枪，所述密封隔离仓1底部设置有排水口，所述排水口上设置有排水阀。这样设置的有益效果是，采用上述方案，在隔离仓内设置清洗喷枪，可以在隔离仓封闭的情况下，对内部进行清洗，整个生产工艺完成后，人工可以通过操作手套操作清洗喷枪对料桶等设备进行冲洗，冲洗后再进行转移，同时清洗后的污水可以通过排水口排出，这种结构简单，避免开启隔离密封仓进行清洗，减少外界污物进入隔离仓的可能，保证设备的使用效果和使用效率。
上述的实施例仅为本发明的优选实施例，不能以此来限定本发明的权利范围，因此，依本发明申请专利范围所作的等同变化，比如采用类似工艺、类似结构的等效产品仍属本发明所涵盖的范围。

Claims (7)

  1. 一种高密闭制粒、干燥、混合一体机，包括机架，所述机架上设置有湿法制粒机、湿整粒机、一步制粒机、干整粒机、缓存罐、提升混合机和料筒，所述湿整粒机设置在湿法制粒机下方并与湿法制粒机出料口连接，所述一步制粒机设置在湿法制粒机一侧，所述一步制粒机进料口与湿整粒机出料口连接，所述干整粒机设置在一步制粒机下方并与一步制粒机出料口连接，所述缓存罐设置在一步制粒机另一侧并与干整粒机出料口连接，其特征在于：所述料筒设置在缓存罐下方，所述提升混合机活动设置在料筒和缓存罐之间，所述机架外罩设有密封隔离仓形成对机架与外界的隔离，所述密封隔离仓上对应机架各位置设置有隔离操作窗，所述隔离操作窗上设置有操作手套，所述密封隔离仓上对应湿法制粒机位置还设置有RPT储料桶，所述RPT储料桶通过RPT隔离阀与密封隔离仓连接实现物料的传递，所述密封隔离仓上还设置有用于在一步制粒机以及缓存罐形成负压环境从而接收物料的排风装置，所述排风装置上设置有排风过滤器。
  2. 根据权利要求1所述的高密闭制粒、干燥、混合一体机，其特征在于：所述提升混合机包括混合料斗和安装座，所述安装座上设置有固定环和用于驱动固定环滑移的驱动气缸，所述混合料斗与固定环固定连接，所述机架上对应提升混合机位置设置有驱动座，所述驱动座上设置有驱动电机，所述驱动电机输出端与安装座传动连接形成对安装座转动的驱动。
  3. 根据权利要求2所述的高密闭制粒、干燥、混合一体机，其特征在于：所述提升混合机与缓存罐之间设置有定位座，所述缓存罐固定设置在定位座上，所述定位座上设置有第一αβ主动阀，所述缓存罐出料口与第一αβ主动阀固定连接，所述混合料斗开口位置设置有αβ被动阀，所述αβ被动阀与第一αβ主动阀连接形成缓存罐与混合料斗的连通，所述料筒开口处设置有第二αβ主动阀，所述第二αβ主动阀与αβ被动阀连接形成混合料斗与料筒的连通。
  4. 根据权利要求2或3所述的高密闭制粒、干燥、混合一体机，其特征在于：所述机架上还设置有垂直定位装置，所述垂直定位装置包括感应探头和定位片，所述感应探头为两个并设置在混合料斗转动轨迹上，两感应探头相对设置，所述定位片设置在混合料斗上，所述所述定位片遮挡在两感应探头之间形成混合料斗在垂直位置的定位。
  5. 根据权利要求1所述的高密闭制粒、干燥、混合一体机，其特征在于：所述密封隔离仓上还设置有进风装置，所述进风装置包括进风管路、进风风机、进风蝶阀和进风过滤器，所述进风风机设置在进风管路内并前置于进风蝶阀，所述进风蝶阀安装在进风管路进风口位置上，所述进风过滤器设置在进风管路进风口对应位置并后置于进风蝶阀，所述进风过滤器包括多层间隔设置的过滤网。
  6. 根据权利要求5所述的高密闭制粒、干燥、混合一体机，其特征在于：所述进风过滤器还包括管路加热器，所述管路加热器设置在进风管路上实现对进风空气的加热。
  7. 根据权利要求1所述的高密闭制粒、干燥、混合一体机，其特征在于：所述密封隔离仓靠近操作手套位置设置有清洗喷枪，所述密封隔离仓底部设置有排水口，所述排水口上设置有排水阀。
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