WO2020261609A1 - Matériau pour timbre médical - Google Patents

Matériau pour timbre médical Download PDF

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Publication number
WO2020261609A1
WO2020261609A1 PCT/JP2019/049904 JP2019049904W WO2020261609A1 WO 2020261609 A1 WO2020261609 A1 WO 2020261609A1 JP 2019049904 W JP2019049904 W JP 2019049904W WO 2020261609 A1 WO2020261609 A1 WO 2020261609A1
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WO
WIPO (PCT)
Prior art keywords
mass
less
fatty acid
sensitive adhesive
pressure
Prior art date
Application number
PCT/JP2019/049904
Other languages
English (en)
Japanese (ja)
Inventor
泰輝 辻
つばさ 宮下
藤澤　博充
Original Assignee
ニチバン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニチバン株式会社 filed Critical ニチバン株式会社
Priority to KR1020217037657A priority Critical patent/KR20220027057A/ko
Priority to CN201980096526.5A priority patent/CN113853414B/zh
Publication of WO2020261609A1 publication Critical patent/WO2020261609A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0256—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the parametric properties of the adhesive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
    • C09J11/02—Non-macromolecular additives
    • C09J11/06—Non-macromolecular additives organic
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J7/00—Adhesives in the form of films or foils
    • C09J7/30—Adhesives in the form of films or foils characterised by the adhesive composition
    • C09J7/38—Pressure-sensitive adhesives [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00412—Plasters use for use with needles, tubes or catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00655—Plasters adhesive
    • A61F2013/00659—Plasters adhesive polymeric base
    • A61F2013/00663—Plasters adhesive polymeric base acrylic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A61M2025/0266—Holding devices, e.g. on the body using pads, patches, tapes or the like

Definitions

  • the present invention relates to a medical patch to be attached to the skin surface such as an adhesive bandage or an adhesive plaster, and an adhesive composition suitable for forming an adhesive layer thereof.
  • a medical patch to be attached to the skin surface such as an adhesive bandage or an adhesive plaster, and an adhesive composition suitable for forming an adhesive layer thereof.
  • the present application claims priority based on Japanese Patent Application No. 2019-12202 filed in Japan on June 28, 2019, the contents of which are incorporated herein by reference.
  • Medical patches such as adhesive bandages and adhesive plasters are also used to fix tubes such as catheters to the skin surface.
  • the medical patch used tends to give priority to high adhesive strength.
  • the catheter or the like may need to be fixed for a long time, or may be repeatedly fixed to the same part of the skin. For this reason, medical patches used for fixing catheters and the like are required to have little effect on the skin when continuously or repeatedly applied.
  • analgesic and anti-inflammatory agents may be repeatedly fixed to the same part of the skin, and are used for medical attachments. It is desirable that the material also has little effect on the skin when it is continuously applied or repeatedly applied.
  • a fatty acid ester compatible with an acrylic acid ester polymer having a weight average molecular weight of 2.5 million or more is liquid-plasticized.
  • a medical patch using an adhesive composition contained as an agent is described.
  • Patent Document 2 describes from a copolymer obtained by emulsion polymerization of a (meth) acrylic acid alkyl ester.
  • a patch material in which a pressure-sensitive adhesive layer obtained by adding a liquid plasticizer such as a fatty acid ester to the acrylic pressure-sensitive adhesive is formed on a support is disclosed.
  • An object of the present invention is to provide a medical patch having sufficient adhesive strength and having a small effect on the skin when repeatedly stuck on the same part of the skin.
  • the present inventors have a weight average molecular weight of 350 or more and 550 or less with respect to 100 parts by mass of an acrylic copolymer in an acrylic pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer of a medical patch, and are liquid at room temperature.
  • fatty ester is contained more than 25 parts by 5 parts by mass or more, further by moisture permeability of the support medical adhesive material to the support is 500g / m 2 ⁇ 24h or more, a high adhesion to human skin
  • the present invention has been completed by finding that a medical patch with a reduced keratin exfoliation area ratio can be obtained while maintaining the above.
  • a medical patch provided with a laminate of a support and an adhesive layer.
  • the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive composition containing a copolymer containing a (meth) acrylic acid alkyl ester as a main component and a fatty acid ester compatible with the copolymer which is liquid at room temperature.
  • the weight average molecular weight of the fatty acid ester contained in the pressure-sensitive adhesive composition is 350 or more and 550 or less.
  • the pressure-sensitive adhesive composition contains 5 parts by mass or more and 25 parts by mass or less of the fatty acid ester with respect to 100 parts by mass of the copolymer.
  • the moisture permeability of the support is 500g / m 2 ⁇ 24h or more, Medical patch material.
  • the copolymer contains 65% by mass or more and 90% by mass or less of acrylic acid alkyl ester having an alkyl group having 8 or more and 12 or less carbon atoms, 2% by mass or more and 15% by mass or less of acrylic acid, and acetic acid.
  • a copolymer obtained by polymerizing 5% by mass or more and 25% by mass or less of vinyl and 0% by mass or more and 10% by mass or less of other vinyl monomers by a solution polymerization method is crosslinked with a cross-linking agent.
  • a medical patch material in which a pressure-sensitive adhesive layer is formed by a pressure-sensitive adhesive composition that is less irritating to the skin even when continuously or repeatedly applied to the same part of the skin while maintaining high adhesive strength. can do.
  • the pressure-sensitive adhesive composition constituting the pressure-sensitive adhesive layer of the medical patch according to the present invention is liquid at room temperature (1 ° C. or higher and 30 ° C. or lower) with a copolymer containing (meth) acrylic acid alkyl ester as a main component.
  • a copolymer containing (meth) acrylic acid alkyl ester as a main component.
  • the fatty acid ester is a liquid plasticizer that is compatible with a copolymer containing a (meth) acrylic acid alkyl ester as a main component and imparts plasticity.
  • a copolymer containing (meth) acrylic acid alkyl ester as a main component (hereinafter, may be referred to as "acrylic copolymer”) is 50 mol% or more (50 mol% or more) of all the constituent units constituting the copolymer (hereinafter, may be referred to as "acrylic copolymer").
  • acrylic copolymer is 50 mol% or more (50 mol% or more) of all the constituent units constituting the copolymer (hereinafter, may be referred to as "acrylic copolymer”).
  • Meta It means a copolymer which is a constituent unit derived from an acrylic acid alkyl ester.
  • (meth) acrylic acid alkyl ester means "acrylic acid alkyl ester and / or methacrylic acid alkyl ester”.
  • a (meth) acrylic acid alkyl ester having an alkyl group portion having 1 or more and 18 or less carbon atoms is preferable. Specifically, methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, t-butyl (meth) acrylate, n (meth) acrylate.
  • a (meth) acrylic acid alkyl ester having an alkyl group having 4 or more and 18 or less carbon atoms is preferable.
  • a (meth) acrylic acid alkyl ester having an alkyl group of 4 or more and 12 or less is more preferable, and a (meth) acrylic acid alkyl ester having an alkyl group of 6 or more and 12 or less has a carbon number of 8 or more and 12 or more.
  • (meth) acrylic acid alkyl esters having the following alkyl groups are 2-ethylhexyl (meth) acrylic acid, n-octyl (meth) acrylic acid, isooctyl (meth) acrylic acid, or isononyl (meth) acrylic acid. Is particularly preferable.
  • the acrylic copolymer used in the present invention is derived from a (meth) acrylic acid alkyl ester having an alkyl group portion having 4 or more and 18 or less carbon atoms as a constituent unit derived from the (meth) acrylic acid alkyl ester.
  • Those containing at least one type of structural unit are preferable.
  • the acrylic copolymer used in the present invention may be a copolymer consisting of only structural units derived from (meth) acrylic acid alkyl ester, or a copolymer containing structural units derived from other polymerizable compounds. It may be a polymer. Examples of other polymerizable compounds include compounds having a vinyl group (vinyl monomer).
  • the vinyl monomer has a functional group such as a hydroxyl group, a carboxyl group, an acid anhydride group, an amide group, an amino group, an epoxy group, an alkoxy group, an acyl group, a cyano group, an aryl group or a heterocyclic group.
  • a functional group such as a hydroxyl group, a carboxyl group, an acid anhydride group, an amide group, an amino group, an epoxy group, an alkoxy group, an acyl group, a cyano group, an aryl group or a heterocyclic group.
  • Examples include vinyl monomers.
  • Examples of the vinyl monomer having a hydroxyl group include a (meth) acrylic acid ester having a hydroxyl group such as 2-hydroxyethyl (meth) acrylate, 3-hydroxypropyl (meth) acrylate, and 4-hydroxybutyl (meth) acrylate. And so on.
  • Examples of the vinyl monomer having a carboxyl group or an acid anhydride group include acrylic acid, methacrylic acid, maleic acid, maleic anhydride, itaconic acid, monobutyl maleate and the like.
  • Examples of the vinyl monomer having an amide group include acrylamide, dimethylacrylamide, diethylacrylamide, methacrylamide, N-methylolacrylamide and the like.
  • Examples of the vinyl monomer having an amino group include dimethylaminoethyl acrylate and the like.
  • Examples of the vinyl monomer having an epoxy group include glycidyl acrylate and glycidyl methacrylate.
  • Examples of the vinyl monomer having an alkoxy group include acrylic acid alkoxyalkyl esters such as 2-methoxyethyl acrylate and ethoxyethyl acrylate.
  • Examples of the vinyl monomer having an acyl group include vinyl esters such as vinyl acetate.
  • Examples of the vinyl monomer having a cyano group include unsaturated nitriles such as acrylonitrile and methacrylonitrile.
  • Examples of the vinyl monomer having an aryl group include vinyl aromatic compounds such as styrene.
  • Examples of the vinyl monomer having a heterocyclic group include a vinyl monomer having a pyrrolidone ring such as N-vinylpyrrolidone. These vinyl monomers can be used alone or in combination of two or more.
  • the acrylic copolymer used in the present invention is preferably a copolymer of a (meth) acrylic acid alkyl ester and another vinyl monomer, and the other vinyl monomer has a hydroxyl group and a hydroxyl group.
  • a vinyl monomer having at least one functional group selected from the group consisting of a carboxyl group, an acid anhydride group, an amide group, an amino group, an epoxy group, and an alkoxy group hereinafter, "vinyl monomer (A)"
  • the copolymer contains at least one kind of vinyl monomer (hereinafter, referred to as “vinyl monomer (B)”) which does not have a functional group. )
  • the acrylic copolymer used in the present invention is an acrylic acid having an alkyl group having 4 or more and 18 or less carbon atoms, preferably 8 or more and 12 or less carbon atoms with respect to the total mass of the monomers used in the copolymerization reaction.
  • the alkyl ester is 55% by mass or more and 95% by mass or less, preferably 60% by mass or more and 95% by mass or less, more preferably 65% by mass or more and 90% by mass or less, still more preferably 80% by mass or more and 90% by mass or less, particularly preferably.
  • vinyl monomer other than vinyl monomer (A) Is 0% by mass or more and 40% by mass or less, preferably 0% by mass or more and 30% by mass or less, more preferably 0% by mass or more and 25% by mass or less, still more preferably 5% by mass or more and 15% by mass or less, and particularly preferably 9% by mass.
  • the acrylic acid alkyl ester having an alkyl group of 8 or more and 12 or less is preferably 55% by mass or more and 95% by mass or less, preferably 60% by mass or more and 95% by mass or less, more preferably 65% by mass or more and 90% by mass or less, further preferably. Is 80% by mass or more and 90% by mass or less, particularly preferably 83% by mass or more and 87% by mass or less, most preferably 85% by mass; vinyl monomer (A) is 1% by mass or more and 25% by mass or less, preferably 1% by mass.
  • the vinyl monomer (B) is 0% by mass or more and 40% by mass or less, preferably 3% by mass or more and 30% by mass or less, more preferably 5% by mass or more and 25% by mass or less, and further preferably 5% by mass or more and 15% by mass or less.
  • the copolymer is particularly preferably 9% by mass or more and 13% by mass or less, most preferably 11% by mass; and 0% by mass or more and 10% by mass or less of other vinyl monomers.
  • the vinyl monomer (A) is acrylic acid and the vinyl monomer (B) is vinyl acetate, and carbon is relative to the total mass of the monomers used in the copolymerization reaction.
  • the number of acrylic acid alkyl esters having an alkyl group of 4 or more and 18 or less, preferably 8 or more and 12 or less is 55% by mass or more and 95% by mass or less, preferably 60% by mass or more and 95% by mass or less, and more preferably 65% by mass or more.
  • acrylic acid is 1% by mass or more and 25% by mass or less, preferably. 1% by mass or more and 20% by mass or less, more preferably 2% by mass or more and 15% by mass or less, further preferably 2% by mass or more and 10% by mass or less, particularly preferably 2% by mass or more and 6% by mass or less, particularly preferably 4% by mass.
  • Vinyl acetate is 0% by mass or more and 40% by mass or less, preferably 3% by mass or more and 30% by mass or less, more preferably 5% by mass or more and 25% by mass or less, still more preferably 5% by mass or more and 15% by mass or less, particularly. It is more preferable that the copolymer is 9% by mass or more and 13% by mass or less, most preferably 11% by mass; and 0% by mass or more and 10% by mass or less of other vinyl monomers.
  • an acrylic copolymer having such a copolymer composition as a pressure-sensitive adhesive, it is possible to form a pressure-sensitive adhesive layer that exhibits appropriate adhesiveness even if the pressure-sensitive adhesive layer is thin and has excellent other properties. It will be easy.
  • the weight average molecular weight of the acrylic copolymer used in the present invention is preferably 300,000 or more and 1,000,000 or less, and more preferably 450,000 or more and 650,000 or less.
  • the weight average molecular weight of the acrylic copolymer is a value obtained as a standard polystyrene-equivalent value by a gel permeation chromatography (GPC) method.
  • the acrylic copolymer used in the present invention can generally be synthesized by radical polymerization.
  • the acrylic copolymer can be produced by a solution polymerization method, a suspension polymerization method, or an emulsion polymerization method, but the solution polymerization method is preferable in that good adhesive properties can be easily obtained.
  • the polymerization initiator include organic peroxides such as benzoyl peroxide and lauroyl peroxide; and azo-based initiators such as azobisisobutyronitrile.
  • a radical polymerization initiator is added at a ratio of 0.1% by mass or more and 3% by mass or less to all the monomers, and the temperature is 40 ° C. or more and 90 ° C.
  • the pressure-sensitive adhesive composition used in the present invention may contain a cross-linking agent.
  • the pressure-sensitive adhesive composition contains a cross-linking agent, the cohesive force of the pressure-sensitive adhesive layer is improved by cross-linking the acrylic copolymer in the pressure-sensitive adhesive composition to form a pressure-sensitive adhesive layer. be able to.
  • cross-linking agent examples include polyfunctional isocyanate compounds [tolylene diisocyanate (TDI), 4,4'-diphenylmethane diisocyanate (MDI), hexamethylene diisocyanate, xylylene diisocyanate, metaxylylene diisocyanate, 1,5-naphthalenedisocyanate, and hydrogenation.
  • TDI polyethylene diisocyanate
  • MDI 4,4'-diphenylmethane diisocyanate
  • hexamethylene diisocyanate xylylene diisocyanate
  • metaxylylene diisocyanate 1,5-naphthalenedisocyanate
  • hydrogenation Diphenylmethane diisocyanate, hydrogenated tolylene diisocyanate, hydride xylylene diisocyanate, isophorone diisocyanate, etc.
  • polyfunctional epoxy compounds acetylacetone metal salts, etc.
  • Coronate (registered trademark) HL, Coronate L, Coronate EH manufactured by Nippon Polyurethane Industry Co., Ltd.
  • TETRAD-X (registered trademark), TETRAD-C (registered trademark), Nasem (registered trademark) manufactured by Mitsubishi Gas Chemical Company, Inc.
  • a commercially available product such as aluminum (registered trademark) can be used as a cross-linking agent.
  • the cross-linking agent may be used alone or in combination of two or more.
  • the content of the cross-linking agent is preferably 0.01 part by mass or more and 1 part by mass or less with respect to 100 parts by mass of the acrylic copolymer. It is preferably 0.03 parts by mass or more and 0.5 parts by mass or less, more preferably 0.04 parts by mass or more and 0.1 parts by mass or less, and particularly preferably 0.04 parts by mass or more and 0.08 parts by mass or less, most preferably. It is 0.06 parts by mass.
  • the cross-linking agent may be contained in the pressure-sensitive adhesive composition in advance, immediately before or when the pressure-sensitive adhesive composition is applied to a support. It may be added to the pressure-sensitive adhesive composition under construction.
  • the liquid plasticizer contained in the pressure-sensitive adhesive layer of the medical patch according to the present invention plasticizes the pressure-sensitive adhesive layer to give a soft feeling, thereby reducing skin irritation.
  • the liquid plasticizer contained in the pressure-sensitive adhesive composition used in the present invention is liquid at room temperature and is compatible with the acrylic copolymer contained in the pressure-sensitive adhesive composition, and has a weight average molecular weight of 350 or more and 550 or less. Fatty acid ester. In the following, when simply referred to as "molecular weight", it means a weight average molecular weight.
  • the (weight average) molecular weight of the fatty acid ester includes the weight average molecular weight of the single type fatty acid ester (in this case, there is almost no molecular weight distribution, and the molecular weight is substantially unique to the single type) and multiple types of fatty acids.
  • the weight average molecular weight of the ester is included.
  • the fatty acid ester contained in the pressure-sensitive adhesive composition that is liquid at room temperature is compatible with the acrylic copolymer contained in the pressure-sensitive adhesive composition, and has a molecular weight of 350 or more and 550 or less. It may be only, or may contain two or more kinds of fatty acid esters.
  • the weight average molecular weight of these fatty acid esters is 350 or more and 550 or less. It should be within the range.
  • a fatty acid ester that is liquid at room temperature has a specific size, and is compatible with the acrylic copolymer, the acrylic copolymer and the fatty acid ester are uniformly mixed, and humans.
  • a pressure-sensitive adhesive layer is formed in which the residue on the skin is sufficiently suppressed when peeled off from the skin while maintaining high adhesive strength to the skin.
  • Fatty acid esters having a molecular weight in the range of 350 or more and 550 or less and having high compatibility with acrylic copolymers can impart sufficient plasticity, and further, a drying step after coating the pressure-sensitive adhesive composition. There is no volatilization in the heating process such as. Therefore, by using a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less as a liquid plasticizer, it is possible to impart appropriate skin adhesiveness when a pressure-sensitive adhesive layer is formed, and keratin that is peeled off at the time of peeling. A pressure-sensitive adhesive composition capable of reducing the area of the above can be obtained.
  • the pressure-sensitive adhesive composition used in the present invention has at least one fatty acid residue (residue derived from fatty acid, specifically, a hydroxyl group from a fatty acid) among fatty acid esters having a molecular weight in the range of 350 or more and 550 or less. It is preferable that the removed group) contains an oleic acid ester which is an oleic acid residue (a group obtained by removing a fatty acid from oleic acid).
  • an oleic acid ester fatty acid ester having at least one oleic acid residue
  • the pressure-sensitive adhesive layer formed from the pressure-sensitive adhesive composition used in the present invention can be continuously applied (long-term application). The effect on the skin is further reduced when it is applied repeatedly.
  • the oleic acid ester may be an ester of a monohydric alcohol and an oleic acid, or an ester of a polyhydric alcohol and an oleic acid.
  • the monohydric alcohol include alkyl alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol and oleyl alcohol.
  • the polyhydric alcohol include glycerin, sorbitol, glycol and the like.
  • an ester of a polyhydric alcohol and an oleic acid only one hydroxyl group in the polyhydric alcohol may be ester-bonded to a fatty acid, or two or more hydroxyl groups may be ester-bonded to a fatty acid.
  • an oleic acid ester in which two or more hydroxyl groups are ester-bonded to a fatty acid, only a part of the fatty acid residues in the ester may be oleic acid residues, and all the fatty acid residues in the ester are oleic acid residues. It may be an ester.
  • oleic acid ester contained in the pressure-sensitive adhesive composition used in the present invention in the range of 350 or more and 550 or less include octyl oleate, lauryl oleate, myristyl oleate, cetyl oleate, and olein.
  • examples thereof include stearyl acid, isostearyl oleate, oleyl oleate, glyceryl monooleate, sorbitan monooleate, and castor oil fatty acid ester.
  • These oleic acid esters may be used alone or in combination of two or more.
  • oleic acid ester contained in the pressure-sensitive adhesive composition used in the present invention examples include glyceryl monooleate (molecular weight: 356.5), sorbitan monooleate (molecular weight: 428.6), and oleic oleate (molecular weight: 531). Is preferable, and oleyl oleate is particularly preferable.
  • the content of the oleic acid ester in the pressure-sensitive adhesive composition used in the present invention in the range of 350 to 550 parts by mass is preferably 1 part by mass or more and 35 parts by mass or less with respect to 100 parts by mass of the acrylic copolymer. , More preferably 5 parts by mass or more and 25 parts by mass or less, and further preferably 10 parts by mass or more and 20 parts by mass or less. If this content is less than 1 part by mass, the plasticizer layer may be insufficiently plasticized and skin irritation may not be reduced. Conversely, if it exceeds 35 parts by mass, the pressure-sensitive adhesive may aggregate. The force may be reduced, leaving adhesive residue on the skin during peeling.
  • fatty acid esters other than oleic acid esters in the pressure-sensitive adhesive composition used in the present invention which have a molecular weight in the range of 350 or more and 550 or less, include isostearyl isostearate (molecular weight: about 537).
  • the pressure-sensitive adhesive composition used in the present invention may contain other liquid plasticizers other than fatty acid esters having a molecular weight in the range of 350 or more and 550 or less as long as the effects of the present invention are not impaired.
  • the other liquid plasticizer is not particularly limited as long as it is a plasticizer that is liquid at room temperature and is compatible with the acrylic copolymer. Examples thereof include oleic acid esters having a molecular weight of less than 350, oleic acid esters having a molecular weight of more than 550, fatty acid esters other than oleic acid esters, and liquid plasticizers other than fatty acid esters.
  • liquid plasticizers other than fatty acid esters include glycols such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol and polypropylene glycol; fats and oils such as olive oil, castor oil, squalane and lanolin; and hydrocarbons such as liquid paraffin. Hydrogens; etc.
  • an organic solvent or a surfactant that is liquid at room temperature can also be used.
  • the fatty acid ester contained in the pressure-sensitive adhesive composition may be compatible with the acrylic copolymer constituting the pressure-sensitive adhesive composition as a whole, and the fatty acid ester incompatible with the acrylic copolymer may be used. It may be contained.
  • the liquid plasticizer contained in the pressure-sensitive adhesive composition used in the present invention is only a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and compatible with an acrylic copolymer.
  • the content of the fatty acid ester having a molecular weight in the range of 350 or more and 550 parts or less in the pressure-sensitive adhesive composition used is preferably 1 part by mass or more and 35 parts by mass or less, more preferably 1 part by mass or less, based on 100 parts by mass of the acrylic copolymer. It is 5 parts by mass or more and 25 parts by mass or less, more preferably 10 parts by mass or more and 20 parts by mass or less.
  • the plasticizer layer may be insufficiently plasticized and skin irritation may not be reduced. Conversely, if it exceeds 35 parts by mass, the pressure-sensitive adhesive may aggregate. The force may be reduced, leaving adhesive residue on the skin during peeling.
  • the molecular weight contained in the acrylic copolymer is in the range of 350 or more and 550 or less and the number of fatty acid esters compatible with the acrylic copolymer is two or more, "molecular weight in the pressure-sensitive adhesive composition".
  • composition of fatty acid ester in the range of 350 or more and 550 or less is the total amount of fatty acid ester corresponding to the fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and compatible with the acrylic copolymer. means.
  • the present invention contains a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and compatible with an acrylic copolymer, and other liquid plasticizers
  • the content of the fatty acid ester having a molecular weight in the range of 350 or more and 550 or less is preferably 50% by mass or more, preferably 60% by mass or more, based on the total amount of the liquid plasticizer contained in the pressure-sensitive adhesive composition used in the present invention. Is more preferable, 80% by mass or more is further preferable, and 90% by mass or more is particularly preferable.
  • the weight average molecular weight of the entire liquid plasticizer contained in the pressure-sensitive adhesive composition particularly, the weight average molecular weight of the entire fatty acid ester liquid at room temperature is preferably in the range of 350 or more and 550 or less.
  • the pressure-sensitive adhesive composition used in the present invention may contain various additives in addition to the cross-linking agent, if necessary.
  • additive it is commonly used in adhesives that form an adhesive layer provided in a patch, such as drugs, fillers, antioxidants (antioxidants, preservatives), colorants, fragrances, and tackifiers.
  • Additives can be included.
  • a tackifier can be added to adjust the adhesive properties of the pressure-sensitive adhesive. Examples of the tackifier include terpene-based, terpene phenol-based, kumaron inden-based, styrene-based, rosin-based, xylene-based, phenol-based, and petroleum-based tackifier resins.
  • the medical patch according to the present invention includes a laminate of a support and an adhesive layer.
  • the medical patch according to the present invention preferably has a pressure-sensitive adhesive layer made of the pressure-sensitive adhesive composition used in the present invention on at least one side of the support. Since the pressure-sensitive adhesive layer is formed by the pressure-sensitive adhesive composition, it is possible to suppress the peeling area of the keratin at the time of peeling while maintaining sufficient adhesive strength to human skin, and it can be continuously applied to the same part of the skin surface or A medical patch material that has little effect on skin irritation even when repeatedly applied can be obtained.
  • the medical patch according to the present invention is a patch that is repeatedly stuck to the same part of the skin such as for fixing a tube such as a catheter, or a specific skin such as a magnetic therapy device adhesive plaster or taping tape. It is suitable for a sticking material that is continuously or repeatedly stuck to a part.
  • moisture permeability is more than 500g / m 2 ⁇ 24h.
  • a support having sufficient moisture permeability it becomes a medical patch material having sufficiently high moisture permeability, less stuffiness when applied to the skin, and less likely to cause skin irritation or itching during application.
  • the moisture permeability of the support preferably at least 500g / m 2 ⁇ 24h, more preferably 700g / m 2 ⁇ 24h or more, still more preferably 1,000g / m 2 ⁇ 24h or more, 1, more preferably more is at 500g / m 2 ⁇ 24h or more, particularly preferably at 5,000g / m 2 ⁇ 24h or more, and most preferably 20,000g / m 2 ⁇ 24h or more.
  • the support examples include impregnated paper, coated paper, high-quality paper, kraft paper, Japanese paper, glassin paper, and other papers; polyester films such as polyethylene terephthalate and polybutylene terephthalate, polyolefin films such as polyethylene and polypropylene, and polyvinyl chloride.
  • Plastic films such as films, polypropylene films, polyurethane films, cellophane films; foams; fabrics such as non-woven fabrics, woven fabrics, knitted fabrics; laminates of two or more of these; and the like.
  • natural materials such as cotton, synthetic resin materials, recycled resin materials and various materials in which these are appropriately combined can be used.
  • Non-woven fabrics, woven fabrics, knitted fabrics, etc. made of cotton or the like can be used.
  • Moisture permeability of the support of the medical adhesive material according to the present invention is 500g / m 2 ⁇ 24h or more. Therefore, as the support, fabrics such as non-woven fabric, woven fabric, and knitted fabric are preferable. Among them, a material that is flexible enough to adhere to the skin and can follow the movement of the skin, and a material that can suppress the occurrence of skin irritation after long-term application are preferable, and the skin under application is preferable.
  • the woven fabric is preferable in that it has excellent followability to the movement of the surface, and further, it is easy to maintain the strength and the self-back surface adhesive force becomes stronger.
  • the thickness of the support can be appropriately selected in consideration of physical properties such as elongation, tensile strength, workability, feel at the time of application, and airtightness of the affected area, but is usually about 5 ⁇ m to 1 mm.
  • the carrier is placed on a surface opposite to one surface of the support provided with the adhesive layer (hereinafter referred to as the other surface). Layers may be provided.
  • the support is a woven fabric
  • its thickness is preferably 50 ⁇ m or more and 1 mm or less, more preferably 100 ⁇ m or more and 800 ⁇ m or less, and further preferably 200 ⁇ m or more and 700 ⁇ m or less.
  • the basis weight is preferably 400 g / m 2 or less, more preferably 300 g / m 2 or less, and further preferably 250 g / m 2 or less from the viewpoint of followability to the skin.
  • the support is a plastic film
  • its thickness is preferably 10 ⁇ m or more and 300 ⁇ m or less, more preferably 12 ⁇ m or more and 200 ⁇ m or less, and further preferably 15 ⁇ m or more and 150 ⁇ m or less.
  • sandblasting or corona treatment is performed on one side or the other side of the support, or both sides thereof, for the purpose of improving the anchoring property of the adhesive layer and the support. Etc. may be performed.
  • the thickness of the support is less than 5 ⁇ m, the strength and handleability of the adhesive tape will decrease, making it difficult to attach it to the skin, tearing it due to contact with other members, or using it with water for bathing, etc. It may peel off from the skin in a short time due to contact.
  • the thickness of the support is too large (more than 1 mm), it becomes difficult for the adhesive tape to follow the movement of the skin, and it becomes easy to form a trigger for peeling at the edge of the adhesive tape, so that the adhesive tape peels off from the skin in a short time. There is a risk that the feeling of discomfort during pasting will increase.
  • the pressure-sensitive adhesive layer is formed by applying the pressure-sensitive adhesive composition used in the present invention to the surface of the support to a desired thickness and drying it.
  • the pressure-sensitive adhesive composition contains a cross-linking agent, a cross-linking treatment according to the type of the cross-linking agent such as an ultraviolet irradiation treatment is performed after coating.
  • the thickness of the pressure-sensitive adhesive layer in the medical patch according to the present invention is not particularly limited, and is preferably 1 ⁇ m or more and 200 ⁇ m or less, more preferably 10 ⁇ m or more and 100 ⁇ m or less, and further preferably 20 ⁇ m or more and 80 ⁇ m or less.
  • the adhesive strength depends on the thickness of the adhesive layer. If the thickness of the adhesive layer is too thick, the adhesive strength becomes too high, and if the thickness of the adhesive layer is too thin, the adhesive strength becomes weak.
  • the thickness of the pressure-sensitive adhesive layer within the above range, in addition to being able to adhere to the skin with sufficient adhesive strength, the adhesive material can be adhered along the surface of the adherend having fine irregularities such as the skin. Furthermore, skin irritation can be suppressed low when peeled off after use.
  • the medical patch according to the present invention may be temporarily attached to a support to form a carrier layer.
  • a support for example, it can be a patch having a laminated structure of "carrier layer / support / adhesive layer / separator layer".
  • the carrier layer can improve the film-forming property of the support, the handleability of the sticking material, and the stickability to the adherend when the thickness of the support is thin. Since the carrier layer is provided to improve the handleability of the sticking material, it may cover the entire surface of the sticking material, only the edge of the sticking material, or a pattern such as a grid pattern. It may be covered in a shape.
  • the carrier layer for example, a film made of various thermoplastic resins such as polyurethane, polyethylene, polypropylene, ionomer, polyamide, polyvinyl chloride, polyvinylidene chloride, ethylene vinyl acetate copolymer, thermoplastic polyester, and polytetrafluoroethylene is used. It is preferable to form it.
  • various thermoplastic resins such as polyurethane, polyethylene, polypropylene, ionomer, polyamide, polyvinyl chloride, polyvinylidene chloride, ethylene vinyl acetate copolymer, thermoplastic polyester, and polytetrafluoroethylene is used. It is preferable to form it.
  • the various films may be laminated on paper. It is preferable that these carrier layers are thicker or stiffer than the support (for example, polyurethane elastomer film).
  • the thickness of the carrier layer can be appropriately set, but is usually 10 ⁇ m or more, preferably 20 ⁇ m or more, and the upper limit thereof is about 500 ⁇ m.
  • the medical patch according to the present invention is usually adjacent to the pressure-sensitive adhesive layer in order to protect the pressure-sensitive adhesive layer until the time when the pressure-sensitive adhesive layer is attached to the skin.
  • a separator layer is provided.
  • the separator layer in the present invention is not particularly limited, and in the technical field of affixing materials, those generally used as release paper, release film, release paper, release film, release liner and the like can be used. .. Specific examples thereof include a polyethylene terephthalate film whose surface is treated with silicone, a laminate of polyethylene whose surface is treated with silicone, and paper. Further, the separator layer may be provided with a cut in order to improve handleability (that is, releasability from the pressure-sensitive adhesive layer), may be formed in a larger area than the sticking material, and a grip portion may be provided on the peripheral edge portion. Good. Further, the separator layer may be provided with irregularities by sandblasting or the like on the surface of the separator layer facing the adhesive layer or the surface opposite to the adhesive layer for the purpose of improving handleability and printability. Good.
  • the thickness of the separator layer can be appropriately set and is not particularly limited, but is usually 20 ⁇ m or more, preferably 40 ⁇ m or more, and the upper limit thereof is about 500 ⁇ m.
  • moisture permeability is at 500g / m 2 ⁇ 24h or more.
  • the patch is, moisture permeability that is 500g / m 2 ⁇ 24h or more, less stuffiness when applied to the skin, hardly occurs itchy skin irritation or sticking in.
  • Moisture permeability of the patch it is more preferably 700g / m 2 ⁇ 24h or more, more preferably 1,000g / m 2 ⁇ 24h or more, 1,500g / m 2 ⁇ 24h or more There still more preferably, particularly preferably at 5,000g / m 2 ⁇ 24h or more, and most preferably 20,000g / m 2 ⁇ 24h or more.
  • the moisture permeability is measured at a temperature of 40 ° C. and a relative humidity of 90% according to the B condition of JIS Z0208. That is, the temperature on one side of the patch is adjusted to 40 ° C. and the relative humidity is 90%, and a moisture absorbent such as calcium chloride is placed on the other side to absorb the moisture that has passed through the patch, and the amount of change in the weight of the moisture absorbent. Is calculated by converting to 24 hours per 1 m 2 .
  • the adhesive strength of the medical patch according to the present invention is preferably 0.5 N / 25 mm or more and 12.0 N / 25 mm or less, more preferably 2.0 N / 25 mm or more and 8.0 N as the adhesive force (peeling force) against bakelite. It is preferably within the range of / 25 mm or less. Since the adhesive strength of the medical patch is within this range, when the medical patch according to the present invention is stuck on the skin surface, it has sufficient sticking performance, does not cause misalignment during sticking, and is said to be relevant. When peeling off the patch, there is no risk of peeling off the skin surface or causing a rash.
  • the method for measuring the adhesive strength of the medical patch is as follows. That is, the sticking material is cut into a predetermined length of 25 mm in width ⁇ 15 mm in length or more, preferably 100 mm to obtain a test piece. The test piece is pressed against a Bakelite test panel to be attached, and then attached with a 2 kg roller at a crimping speed of 300 mm / min and one reciprocating crimping frequency to prepare a test piece. After 20 minutes have passed since the application, the adhesive strength is applied under the conditions of a peeling angle of 180 ° and a peeling speed of 300 mm / minute in accordance with the peeling adhesive strength test method of ISO29862 method 1 (corresponding JIS: JIS Z0237). Measure.
  • the method for producing the medical patch according to the present invention is not particularly limited.
  • a method for continuously forming the pressure-sensitive adhesive layer a method in which the pressure-sensitive adhesive solution is applied onto the separator layer while running in one direction and dried is preferable.
  • a method of melting the adhesive and applying it on the separator layer may be adopted. It can also be a repeating pattern coating of a specific shape.
  • Lamination of "support / adhesive layer / separator layer” by adhering a laminate having an adhesive layer formed on one side of the separator layer and a support so that the adhesive layer and the surface of the support are in close contact with each other.
  • a patch having a structure can be produced.
  • the adhesive layer and the surface of the support of the laminated body are bonded so as to be in close contact with each other to form a “carrier layer (arbitrary layer)”.
  • a patch material having a laminated structure of "/ support / adhesive layer / separator layer” can be produced.
  • Examples 1 to 4, Comparative Examples 1 to 7 A pressure-sensitive adhesive composition containing various liquid plasticizers was prepared, and the adhesive strength and the effect on human skin of the adhesive material on which the pressure-sensitive adhesive layer was formed were investigated.
  • the liquid plasticizer methyl oleate (molecular weight: 296.5), isopropyl myristate (molecular weight: 268.0), glyceryl monooleate (molecular weight: 356.0), sorbitan monooleate (molecular weight: 428.6).
  • Oleyl oleate (molecular weight: 531.0), isostearyl isostearate (molecular weight: 537.0), soybean oil (molecular weight: about 880, SR soybean-LQ- (JP), manufactured by Claude Japan), triolein Polysorbate acid (molecular weight: 935.0), castor oil fatty acid ester (molecular weight: about 500, Ricksizer C-101, manufactured by Ito Oil Co., Ltd.), decyl oleate (molecular weight: 422.4), special castor oil-based condensed fatty acid (molecular weight: 422.4) Molecular weight: 800, Minerazole, manufactured by Ito Oil Co., Ltd.) was used.
  • woven warp: corespun, weft: cotton, moisture permeability: 21,060g / m 2 ⁇ 24h, basis weight 155 g / m 2)
  • urethane nonwoven fiber diameter: 15 [mu] m, moisture permeability: 21, 590g / m 2 ⁇ 24h, basis weight 65g / m 2)
  • polyethylene film thickness: 50 [mu] m, moisture permeability: 60g / m 2 ⁇ 24h
  • the liquid plastic agents shown in Tables 1 to 3 were mixed with 100 parts by mass of the acrylic copolymer in the solution of the above so as to have the parts by mass shown in Table 1, and Tetrad-X (Mitsubishi Gas) was further used as a cross-linking agent.
  • a uniform solution of the pressure-sensitive adhesive composition was prepared by mixing 0.06 parts by mass (manufactured by Kagaku Co., Ltd.).
  • This pressure-sensitive adhesive composition was applied to the peel-treated surface of the separator (silicone-treated polylami release paper) so that the thickness after drying was 38 ⁇ m, and dried to form a pressure-sensitive adhesive layer.
  • This pressure-sensitive adhesive layer was bonded to the supports shown in Tables 1 to 3 to prepare a patch.
  • the adhesive strength of each test sample to human skin is 10 parts by mass of the fatty acid ester with respect to 100 parts by mass of the acrylic copolymer.
  • the numerical value was higher than that of the test sample not containing the fatty acid ester (Comparative Example 1). Yes, the adhesive strength could be enhanced by blending the fatty acid ester.
  • the test sample (Comparative Example 4) in which 30 parts by mass of the fatty acid ester was mixed with 100 parts by mass of the acrylic copolymer, adhesive residue was generated at the time of peeling.
  • test sample (Comparative Example 7) in which decyl oleate, which is inferior in compatibility with the acrylic copolymer, was selected, had adhesive residue in the adhesive residue test, which caused a problem as a medical patch. It was something.
  • the exfoliation area ratio of each test sample was compared with Comparative Example 1 in the test samples (Examples 1 to 6) containing a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and having good compatibility with the acrylic copolymer.
  • the keratin exfoliation area ratio was about 40%, which was sufficiently low.
  • Comparative Example 2 Comparative Examples 5, 6 and 8 containing fatty acid esters having a molecular weight outside the range, the keratin exfoliation area ratio is 50% or more, and the reduction effect is small. I was able to confirm that.
  • test samples (Examples 1 to 6) containing a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and having good compatibility with the acrylic copolymer were almost in a skin state over time. It was confirmed that the amount was maintained without decreasing. In addition, it was confirmed that few subjects remained reddish even 24 hours after the peeling on the end date of the test.
  • Example 3 Comparative Example 9
  • Example moisture permeability Comparative example 500 g / m 2 ⁇ but 24h the at is woven more was example 3 and comparable without evaluation result of the support
  • the moisture permeability was polyethylene film is 60 g / m 2 ⁇ 24h and the support
  • the keratin thin area ratio was low, the human skin adhesive strength was significantly reduced and the skin reaction was also strong.
  • moisture permeability of the woven or nonwoven fabric is 500g / m 2 ⁇ 24h or more as a support for the pressure-sensitive adhesive layer including the acrylic copolymer, the compatibility with the acrylic copolymer
  • a pressure-sensitive adhesive layer with low skin irritation is formed even when continuously or repeatedly applied to the same part of the skin while maintaining high adhesive strength. It is clear that it can be done.

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Abstract

L'invention concerne un matériau pour timbre médical, comprenant un stratifié d'un support et une couche adhésive, la couche adhésive comprenant une composition adhésive contenant un copolymère dans lequel un ester alkylique de l'acide (méth)acrylique est le constituant principal et un ester d'acide gras compatible avec le copolymère lorsque le copolymère est liquide à la température ambiante, l'ester d'acide gras contenu dans la composition adhésive ayant une masse moléculaire moyenne en masse de 350 à 550, la composition adhésive contenant 5 à 25 parties en masse d'un ester d'acide gras pour 100 parties en masse du copolymère, et le support ayant une perméabilité à l'humidité de 500 g/m2·24 h ou plus.
PCT/JP2019/049904 2018-06-29 2019-12-19 Matériau pour timbre médical WO2020261609A1 (fr)

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Citations (6)

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Publication number Priority date Publication date Assignee Title
JP2002065841A (ja) * 2000-09-01 2002-03-05 Nitto Denko Corp 皮膚貼付用粘着剤組成物、および皮膚貼付用粘着テープもしくはシート
JP2005089438A (ja) * 2003-09-19 2005-04-07 Kosumedei:Kk 皮膚用粘着剤組成物及び皮膚用粘着テープまたはシート
WO2007126067A1 (fr) * 2006-04-28 2007-11-08 Lion Corporation Composition adhesive sensible a la pression non aqueuse, patchs et leurs procedes de production
JP2007296120A (ja) * 2006-04-28 2007-11-15 Lion Corp 貼付剤
JP2009155306A (ja) * 2007-12-28 2009-07-16 Lion Corp 貼付剤
JP2018023784A (ja) * 2016-08-09 2018-02-15 日東電工株式会社 皮膚貼付材ならびに皮膚貼付材巻回体

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
JP2002065841A (ja) * 2000-09-01 2002-03-05 Nitto Denko Corp 皮膚貼付用粘着剤組成物、および皮膚貼付用粘着テープもしくはシート
JP2005089438A (ja) * 2003-09-19 2005-04-07 Kosumedei:Kk 皮膚用粘着剤組成物及び皮膚用粘着テープまたはシート
WO2007126067A1 (fr) * 2006-04-28 2007-11-08 Lion Corporation Composition adhesive sensible a la pression non aqueuse, patchs et leurs procedes de production
JP2007296120A (ja) * 2006-04-28 2007-11-15 Lion Corp 貼付剤
JP2009155306A (ja) * 2007-12-28 2009-07-16 Lion Corp 貼付剤
JP2018023784A (ja) * 2016-08-09 2018-02-15 日東電工株式会社 皮膚貼付材ならびに皮膚貼付材巻回体

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CN113853414B (zh) 2023-12-08

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