WO2020261609A1

WO2020261609A1 - Medical patch material

Info

Publication number: WO2020261609A1
Application number: PCT/JP2019/049904
Authority: WO
Inventors: 泰輝辻; つばさ宮下; 藤澤　博充
Original assignee: ニチバン株式会社
Priority date: 2018-06-29
Filing date: 2019-12-19
Publication date: 2020-12-30
Also published as: KR20220027057A; CN113853414A; JP7369552B2; CN113853414B; JP2020006166A

Abstract

This medical patch material comprises a laminate of a support and an adhesive layer, wherein the adhesive layer comprises an adhesive composition containing a copolymer in which a (meth)acrylic acid alkyl ester is the main component and a fatty acid ester compatible with the copolymer when the copolymer is liquid at room temperature, the fatty acid ester contained in the adhesive composition has a weight-average molecular weight of 350-550, the adhesive composition contains 5-25 parts by mass of the fatty acid ester with respect to 100 parts by mass of the copolymer, and the support has a moisture permeability of 500 g/m²·24 h or more.

Description

Medical patch

The present invention relates to a medical patch to be attached to the skin surface such as an adhesive bandage or an adhesive plaster, and an adhesive composition suitable for forming an adhesive layer thereof. The present application claims priority based on Japanese Patent Application No. 2019-12202 filed in Japan on June 28, 2019, the contents of which are incorporated herein by reference.

Medical patches such as adhesive bandages and adhesive plasters are also used to fix tubes such as catheters to the skin surface. When fixing a catheter or the like, it is necessary to stably fix the catheter or the like so that it will not be accidentally peeled off. Therefore, the medical patch used tends to give priority to high adhesive strength. On the other hand, the catheter or the like may need to be fixed for a long time, or may be repeatedly fixed to the same part of the skin. For this reason, medical patches used for fixing catheters and the like are required to have little effect on the skin when continuously or repeatedly applied. In addition, analgesic and anti-inflammatory agents, magnetic therapy device adhesive plasters, taping tapes, etc., which are attached to specific parts such as shoulders and hips, may be repeatedly fixed to the same part of the skin, and are used for medical attachments. It is desirable that the material also has little effect on the skin when it is continuously applied or repeatedly applied.

As a medical patch material that suppresses irritation to the skin, for example, in Patent Document 1, as an adhesive, a fatty acid ester compatible with an acrylic acid ester polymer having a weight average molecular weight of 2.5 million or more is liquid-plasticized. A medical patch using an adhesive composition contained as an agent is described. By using an acrylic acid ester polymer with good adhesiveness as the pressure-sensitive adhesive layer and containing a fatty acid ester compatible with the pressure-sensitive adhesive layer as a liquid plasticizer, the pressure-sensitive adhesive layer is plasticized and softened, and skin irritation is reduced. To.

Further, as a medical patch material provided with a pressure-sensitive adhesive layer in which a liquid plasticizer is mixed in the pressure-sensitive adhesive layer, for example, Patent Document 2 describes from a copolymer obtained by emulsion polymerization of a (meth) acrylic acid alkyl ester. A patch material in which a pressure-sensitive adhesive layer obtained by adding a liquid plasticizer such as a fatty acid ester to the acrylic pressure-sensitive adhesive is formed on a support is disclosed.

Japanese Patent Application Laid-Open No. 11-76392 Japanese Patent Application Laid-Open No. 2009-155306

An object of the present invention is to provide a medical patch having sufficient adhesive strength and having a small effect on the skin when repeatedly stuck on the same part of the skin.

The present inventors have a weight average molecular weight of 350 or more and 550 or less with respect to 100 parts by mass of an acrylic copolymer in an acrylic pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer of a medical patch, and are liquid at room temperature. fatty ester is contained more than 25 parts by 5 parts by mass or more, further by moisture permeability of the support medical adhesive material to the support is 500g / m 2 · ^24h or more, a high adhesion to human skin The present invention has been completed by finding that a medical patch with a reduced keratin exfoliation area ratio can be obtained while maintaining the above.

That is, the present invention provides the following medical patches.
[1] A medical patch provided with a laminate of a support and an adhesive layer.
The pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive composition containing a copolymer containing a (meth) acrylic acid alkyl ester as a main component and a fatty acid ester compatible with the copolymer which is liquid at room temperature.
The weight average molecular weight of the fatty acid ester contained in the pressure-sensitive adhesive composition is 350 or more and 550 or less.
The pressure-sensitive adhesive composition contains 5 parts by mass or more and 25 parts by mass or less of the fatty acid ester with respect to 100 parts by mass of the copolymer.
The moisture permeability of the support is 500g ^/ m 2 · 24h or more,
Medical patch material.
[2] The medical patch according to the above [1], wherein the fatty acid ester contains a single type of fatty acid ester having a weight average molecular weight of 350 or more and 550 or less.
[3] The copolymer contains 65% by mass or more and 90% by mass or less of acrylic acid alkyl ester having an alkyl group having 8 or more and 12 or less carbon atoms, 2% by mass or more and 15% by mass or less of acrylic acid, and acetic acid. A copolymer obtained by polymerizing 5% by mass or more and 25% by mass or less of vinyl and 0% by mass or more and 10% by mass or less of other vinyl monomers by a solution polymerization method is crosslinked with a cross-linking agent. , The medical patch material of the above [1] or [2].
[4] The medical patch according to any one of [1] to [3] above, wherein the fatty acid ester has at least one oleic acid residue.
[5] The medical patch according to the above [4], wherein all the fatty acid residues in the fatty acid ester are oleic acid residues.
[6] The medical patch according to any one of [1] to [5], further comprising a separator layer on a surface of the pressure-sensitive adhesive layer opposite to the surface in contact with the support.
[7] The medical patch according to any one of [1] to [6] above, which is repeatedly stuck to the same part of the skin.
[8] The medical patch according to any one of [1] to [7] above, which is used for fixing a tube.

According to the present invention, there is provided a medical patch material in which a pressure-sensitive adhesive layer is formed by a pressure-sensitive adhesive composition that is less irritating to the skin even when continuously or repeatedly applied to the same part of the skin while maintaining high adhesive strength. can do.

<Adhesive composition>
The pressure-sensitive adhesive composition constituting the pressure-sensitive adhesive layer of the medical patch according to the present invention is liquid at room temperature (1 ° C. or higher and 30 ° C. or lower) with a copolymer containing (meth) acrylic acid alkyl ester as a main component. Contains fatty acid ester. The fatty acid ester is a liquid plasticizer that is compatible with a copolymer containing a (meth) acrylic acid alkyl ester as a main component and imparts plasticity.

(Copolymer containing (meth) acrylic acid alkyl ester as the main component)
A copolymer containing (meth) acrylic acid alkyl ester as a main component (hereinafter, may be referred to as "acrylic copolymer") is 50 mol% or more (50 mol% or more) of all the constituent units constituting the copolymer (hereinafter, may be referred to as "acrylic copolymer"). Meta) It means a copolymer which is a constituent unit derived from an acrylic acid alkyl ester. In addition, in this invention and this specification, (meth) acrylic acid alkyl ester means "acrylic acid alkyl ester and / or methacrylic acid alkyl ester".

As the (meth) acrylic acid alkyl ester from which the constituent unit of the copolymer is derived, a (meth) acrylic acid alkyl ester having an alkyl group portion having 1 or more and 18 or less carbon atoms is preferable. Specifically, methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, t-butyl (meth) acrylate, n (meth) acrylate. -Hexyl, n-octyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, isooctyl (meth) acrylate, isononyl (meth) acrylate, n-decyl (meth) acrylate, isodecyl (meth) acrylate , (Meta) lauryl acrylate, stearyl (meth) acrylate and the like. These (meth) acrylic acid alkyl esters can be used alone or in combination of two or more.

As the (meth) acrylic acid alkyl ester from which the structural unit of the acrylic copolymer used in the present invention is derived, a (meth) acrylic acid alkyl ester having an alkyl group having 4 or more and 18 or less carbon atoms is preferable. A (meth) acrylic acid alkyl ester having an alkyl group of 4 or more and 12 or less is more preferable, and a (meth) acrylic acid alkyl ester having an alkyl group of 6 or more and 12 or less has a carbon number of 8 or more and 12 or more. More preferably, (meth) acrylic acid alkyl esters having the following alkyl groups are 2-ethylhexyl (meth) acrylic acid, n-octyl (meth) acrylic acid, isooctyl (meth) acrylic acid, or isononyl (meth) acrylic acid. Is particularly preferable.

The acrylic copolymer used in the present invention is derived from a (meth) acrylic acid alkyl ester having an alkyl group portion having 4 or more and 18 or less carbon atoms as a constituent unit derived from the (meth) acrylic acid alkyl ester. Those containing at least one type of structural unit are preferable. For example, a copolymer having only a structural unit derived from a (meth) acrylic acid alkyl ester having an alkyl group portion having 4 or more and 18 or less carbon atoms as a structural unit derived from the (meth) acrylic acid alkyl ester. It may be, and the structural unit derived from the (meth) acrylic acid alkyl ester having 4 or more and 18 or less carbon atoms in the alkyl group portion and the other structural unit derived from the (meth) acrylic acid alkyl ester. It may be a copolymer containing both.

The acrylic copolymer used in the present invention may be a copolymer consisting of only structural units derived from (meth) acrylic acid alkyl ester, or a copolymer containing structural units derived from other polymerizable compounds. It may be a polymer. Examples of other polymerizable compounds include compounds having a vinyl group (vinyl monomer).

The vinyl monomer has a functional group such as a hydroxyl group, a carboxyl group, an acid anhydride group, an amide group, an amino group, an epoxy group, an alkoxy group, an acyl group, a cyano group, an aryl group or a heterocyclic group. Examples include vinyl monomers. Examples of the vinyl monomer having a hydroxyl group include a (meth) acrylic acid ester having a hydroxyl group such as 2-hydroxyethyl (meth) acrylate, 3-hydroxypropyl (meth) acrylate, and 4-hydroxybutyl (meth) acrylate. And so on. Examples of the vinyl monomer having a carboxyl group or an acid anhydride group include acrylic acid, methacrylic acid, maleic acid, maleic anhydride, itaconic acid, monobutyl maleate and the like. Examples of the vinyl monomer having an amide group include acrylamide, dimethylacrylamide, diethylacrylamide, methacrylamide, N-methylolacrylamide and the like. Examples of the vinyl monomer having an amino group include dimethylaminoethyl acrylate and the like. Examples of the vinyl monomer having an epoxy group include glycidyl acrylate and glycidyl methacrylate. Examples of the vinyl monomer having an alkoxy group include acrylic acid alkoxyalkyl esters such as 2-methoxyethyl acrylate and ethoxyethyl acrylate. Examples of the vinyl monomer having an acyl group include vinyl esters such as vinyl acetate. Examples of the vinyl monomer having a cyano group include unsaturated nitriles such as acrylonitrile and methacrylonitrile. Examples of the vinyl monomer having an aryl group include vinyl aromatic compounds such as styrene. Examples of the vinyl monomer having a heterocyclic group include a vinyl monomer having a pyrrolidone ring such as N-vinylpyrrolidone. These vinyl monomers can be used alone or in combination of two or more.

The acrylic copolymer used in the present invention is preferably a copolymer of a (meth) acrylic acid alkyl ester and another vinyl monomer, and the other vinyl monomer has a hydroxyl group and a hydroxyl group. A vinyl monomer having at least one functional group selected from the group consisting of a carboxyl group, an acid anhydride group, an amide group, an amino group, an epoxy group, and an alkoxy group (hereinafter, "vinyl monomer (A)"). It is more preferable that the copolymer contains at least one kind of vinyl monomer (hereinafter, referred to as “vinyl monomer (B)”) which does not have a functional group. ) Is preferably a copolymer containing at least one kind.

The acrylic copolymer used in the present invention is an acrylic acid having an alkyl group having 4 or more and 18 or less carbon atoms, preferably 8 or more and 12 or less carbon atoms with respect to the total mass of the monomers used in the copolymerization reaction. The alkyl ester is 55% by mass or more and 95% by mass or less, preferably 60% by mass or more and 95% by mass or less, more preferably 65% by mass or more and 90% by mass or less, still more preferably 80% by mass or more and 90% by mass or less, particularly preferably. 83% by mass or more and 87% by mass or less, most preferably 85% by mass; 1% by mass or more and 25% by mass or less of the vinyl monomer (A), preferably 1% by mass or more and 20% by mass or less, more preferably 2% by mass. 15% by mass or less, more preferably 2% by mass or more and 10% by mass or less, particularly preferably 2% by mass or more and 6% by mass or less, particularly preferably 4% by mass; vinyl monomer other than vinyl monomer (A) Is 0% by mass or more and 40% by mass or less, preferably 0% by mass or more and 30% by mass or less, more preferably 0% by mass or more and 25% by mass or less, still more preferably 5% by mass or more and 15% by mass or less, and particularly preferably 9% by mass. % Or more and 13% by mass or less, most preferably 11% by mass; and other vinyl monomers of 0% by mass or more and 10% by mass or less; preferably a copolymer having 4 or more and 18% or less carbon atoms. The acrylic acid alkyl ester having an alkyl group of 8 or more and 12 or less is preferably 55% by mass or more and 95% by mass or less, preferably 60% by mass or more and 95% by mass or less, more preferably 65% by mass or more and 90% by mass or less, further preferably. Is 80% by mass or more and 90% by mass or less, particularly preferably 83% by mass or more and 87% by mass or less, most preferably 85% by mass; vinyl monomer (A) is 1% by mass or more and 25% by mass or less, preferably 1% by mass. % Or more and 20% by mass or less, more preferably 2% by mass or more and 15% by mass or less, further preferably 2% by mass or more and 10% by mass or less, particularly preferably 2% by mass or more and 6% by mass or less, and particularly preferably 4% by mass; The vinyl monomer (B) is 0% by mass or more and 40% by mass or less, preferably 3% by mass or more and 30% by mass or less, more preferably 5% by mass or more and 25% by mass or less, and further preferably 5% by mass or more and 15% by mass or less. Hereinafter, it is more preferable that the copolymer is particularly preferably 9% by mass or more and 13% by mass or less, most preferably 11% by mass; and 0% by mass or more and 10% by mass or less of other vinyl monomers. Among them, it is particularly preferable that the vinyl monomer (A) is acrylic acid and the vinyl monomer (B) is vinyl acetate, and carbon is relative to the total mass of the monomers used in the copolymerization reaction. The number of acrylic acid alkyl esters having an alkyl group of 4 or more and 18 or less, preferably 8 or more and 12 or less is 55% by mass or more and 95% by mass or less, preferably 60% by mass or more and 95% by mass or less, and more preferably 65% by mass or more. 90% by mass or less, more preferably 80% by mass or more and 90% by mass or less, particularly preferably 83% by mass or more and 87% by mass or less, most preferably 85% by mass; acrylic acid is 1% by mass or more and 25% by mass or less, preferably. 1% by mass or more and 20% by mass or less, more preferably 2% by mass or more and 15% by mass or less, further preferably 2% by mass or more and 10% by mass or less, particularly preferably 2% by mass or more and 6% by mass or less, particularly preferably 4% by mass. %; Vinyl acetate is 0% by mass or more and 40% by mass or less, preferably 3% by mass or more and 30% by mass or less, more preferably 5% by mass or more and 25% by mass or less, still more preferably 5% by mass or more and 15% by mass or less, particularly. It is more preferable that the copolymer is 9% by mass or more and 13% by mass or less, most preferably 11% by mass; and 0% by mass or more and 10% by mass or less of other vinyl monomers. By using an acrylic copolymer having such a copolymer composition as a pressure-sensitive adhesive, it is possible to form a pressure-sensitive adhesive layer that exhibits appropriate adhesiveness even if the pressure-sensitive adhesive layer is thin and has excellent other properties. It will be easy.

The weight average molecular weight of the acrylic copolymer used in the present invention is preferably 300,000 or more and 1,000,000 or less, and more preferably 450,000 or more and 650,000 or less. By setting the weight average molecular weight of the acrylic copolymer within the above range, it is possible to balance cohesiveness, adhesive strength, workability of mixing with other components, affinity with other components, and the like. If the molecular weight is less than 300,000, the cohesiveness is lowered, which may cause adhesive residue on the skin at the time of peeling. If the weight average molecular weight exceeds 1,000,000, the handleability at the time of manufacture is inferior. The weight average molecular weight of the acrylic copolymer is a value obtained as a standard polystyrene-equivalent value by a gel permeation chromatography (GPC) method.

The acrylic copolymer used in the present invention can generally be synthesized by radical polymerization. The acrylic copolymer can be produced by a solution polymerization method, a suspension polymerization method, or an emulsion polymerization method, but the solution polymerization method is preferable in that good adhesive properties can be easily obtained. Examples of the polymerization initiator include organic peroxides such as benzoyl peroxide and lauroyl peroxide; and azo-based initiators such as azobisisobutyronitrile. A radical polymerization initiator is added at a ratio of 0.1% by mass or more and 3% by mass or less to all the monomers, and the temperature is 40 ° C. or more and 90 ° C. or less under a nitrogen stream for several hours to several tens of hours. Stir to copolymerize. In the solution polymerization method, ethyl acetate, acetone, toluene, a mixture thereof and the like are widely used as the solvent.

(Crosslinks and crosslinkers)
The pressure-sensitive adhesive composition used in the present invention may contain a cross-linking agent. When the pressure-sensitive adhesive composition contains a cross-linking agent, the cohesive force of the pressure-sensitive adhesive layer is improved by cross-linking the acrylic copolymer in the pressure-sensitive adhesive composition to form a pressure-sensitive adhesive layer. be able to.

Examples of the cross-linking agent include polyfunctional isocyanate compounds [tolylene diisocyanate (TDI), 4,4'-diphenylmethane diisocyanate (MDI), hexamethylene diisocyanate, xylylene diisocyanate, metaxylylene diisocyanate, 1,5-naphthalenedisocyanate, and hydrogenation. Diphenylmethane diisocyanate, hydrogenated tolylene diisocyanate, hydride xylylene diisocyanate, isophorone diisocyanate, etc.], polyfunctional epoxy compounds, acetylacetone metal salts, etc. may be mentioned. Further, for example, Coronate (registered trademark) HL, Coronate L, Coronate EH manufactured by Nippon Polyurethane Industry Co., Ltd., TETRAD-X, (registered trademark), TETRAD-C (registered trademark), Nasem (registered trademark) manufactured by Mitsubishi Gas Chemical Company, Inc. A commercially available product such as aluminum (registered trademark) can be used as a cross-linking agent. The cross-linking agent may be used alone or in combination of two or more.

When the pressure-sensitive adhesive composition used in the present invention contains a cross-linking agent, the content of the cross-linking agent is preferably 0.01 part by mass or more and 1 part by mass or less with respect to 100 parts by mass of the acrylic copolymer. It is preferably 0.03 parts by mass or more and 0.5 parts by mass or less, more preferably 0.04 parts by mass or more and 0.1 parts by mass or less, and particularly preferably 0.04 parts by mass or more and 0.08 parts by mass or less, most preferably. It is 0.06 parts by mass.

When the pressure-sensitive adhesive composition used in the present invention contains a cross-linking agent, the cross-linking agent may be contained in the pressure-sensitive adhesive composition in advance, immediately before or when the pressure-sensitive adhesive composition is applied to a support. It may be added to the pressure-sensitive adhesive composition under construction.

(Liquid plasticizer)
The liquid plasticizer contained in the pressure-sensitive adhesive layer of the medical patch according to the present invention plasticizes the pressure-sensitive adhesive layer to give a soft feeling, thereby reducing skin irritation. The liquid plasticizer contained in the pressure-sensitive adhesive composition used in the present invention is liquid at room temperature and is compatible with the acrylic copolymer contained in the pressure-sensitive adhesive composition, and has a weight average molecular weight of 350 or more and 550 or less. Fatty acid ester. In the following, when simply referred to as "molecular weight", it means a weight average molecular weight. In addition, the (weight average) molecular weight of the fatty acid ester includes the weight average molecular weight of the single type fatty acid ester (in this case, there is almost no molecular weight distribution, and the molecular weight is substantially unique to the single type) and multiple types of fatty acids. The weight average molecular weight of the ester is included. The fatty acid ester contained in the pressure-sensitive adhesive composition that is liquid at room temperature is compatible with the acrylic copolymer contained in the pressure-sensitive adhesive composition, and has a molecular weight of 350 or more and 550 or less. It may be only, or may contain two or more kinds of fatty acid esters. When two or more types of fatty acid esters that are liquid at room temperature and compatible with the acrylic copolymer contained in the pressure-sensitive adhesive composition are contained, the weight average molecular weight of these fatty acid esters is 350 or more and 550 or less. It should be within the range. By using a fatty acid ester that is liquid at room temperature, has a specific size, and is compatible with the acrylic copolymer, the acrylic copolymer and the fatty acid ester are uniformly mixed, and humans. A pressure-sensitive adhesive layer is formed in which the residue on the skin is sufficiently suppressed when peeled off from the skin while maintaining high adhesive strength to the skin.

Fatty acid esters having a molecular weight in the range of 350 or more and 550 or less and having high compatibility with acrylic copolymers can impart sufficient plasticity, and further, a drying step after coating the pressure-sensitive adhesive composition. There is no volatilization in the heating process such as. Therefore, by using a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less as a liquid plasticizer, it is possible to impart appropriate skin adhesiveness when a pressure-sensitive adhesive layer is formed, and keratin that is peeled off at the time of peeling. A pressure-sensitive adhesive composition capable of reducing the area of the above can be obtained.

The pressure-sensitive adhesive composition used in the present invention has at least one fatty acid residue (residue derived from fatty acid, specifically, a hydroxyl group from a fatty acid) among fatty acid esters having a molecular weight in the range of 350 or more and 550 or less. It is preferable that the removed group) contains an oleic acid ester which is an oleic acid residue (a group obtained by removing a fatty acid from oleic acid). When an oleic acid ester (fatty acid ester having at least one oleic acid residue) is used as the liquid plasticizer, the pressure-sensitive adhesive layer formed from the pressure-sensitive adhesive composition used in the present invention can be continuously applied (long-term application). The effect on the skin is further reduced when it is applied repeatedly.

The oleic acid ester may be an ester of a monohydric alcohol and an oleic acid, or an ester of a polyhydric alcohol and an oleic acid. Examples of the monohydric alcohol include alkyl alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol and oleyl alcohol. Examples of the polyhydric alcohol include glycerin, sorbitol, glycol and the like.

In the case of an ester of a polyhydric alcohol and an oleic acid, only one hydroxyl group in the polyhydric alcohol may be ester-bonded to a fatty acid, or two or more hydroxyl groups may be ester-bonded to a fatty acid. In the case of an oleic acid ester in which two or more hydroxyl groups are ester-bonded to a fatty acid, only a part of the fatty acid residues in the ester may be oleic acid residues, and all the fatty acid residues in the ester are oleic acid residues. It may be an ester.

Specific examples of the oleic acid ester contained in the pressure-sensitive adhesive composition used in the present invention in the range of 350 or more and 550 or less include octyl oleate, lauryl oleate, myristyl oleate, cetyl oleate, and olein. Examples thereof include stearyl acid, isostearyl oleate, oleyl oleate, glyceryl monooleate, sorbitan monooleate, and castor oil fatty acid ester. These oleic acid esters may be used alone or in combination of two or more. Examples of the oleic acid ester contained in the pressure-sensitive adhesive composition used in the present invention include glyceryl monooleate (molecular weight: 356.5), sorbitan monooleate (molecular weight: 428.6), and oleic oleate (molecular weight: 531). Is preferable, and oleyl oleate is particularly preferable.

The content of the oleic acid ester in the pressure-sensitive adhesive composition used in the present invention in the range of 350 to 550 parts by mass is preferably 1 part by mass or more and 35 parts by mass or less with respect to 100 parts by mass of the acrylic copolymer. , More preferably 5 parts by mass or more and 25 parts by mass or less, and further preferably 10 parts by mass or more and 20 parts by mass or less. If this content is less than 1 part by mass, the plasticizer layer may be insufficiently plasticized and skin irritation may not be reduced. Conversely, if it exceeds 35 parts by mass, the pressure-sensitive adhesive may aggregate. The force may be reduced, leaving adhesive residue on the skin during peeling.

Examples of fatty acid esters other than oleic acid esters in the pressure-sensitive adhesive composition used in the present invention, which have a molecular weight in the range of 350 or more and 550 or less, include isostearyl isostearate (molecular weight: about 537).

The pressure-sensitive adhesive composition used in the present invention may contain other liquid plasticizers other than fatty acid esters having a molecular weight in the range of 350 or more and 550 or less as long as the effects of the present invention are not impaired. The other liquid plasticizer is not particularly limited as long as it is a plasticizer that is liquid at room temperature and is compatible with the acrylic copolymer. Examples thereof include oleic acid esters having a molecular weight of less than 350, oleic acid esters having a molecular weight of more than 550, fatty acid esters other than oleic acid esters, and liquid plasticizers other than fatty acid esters. Examples of liquid plasticizers other than fatty acid esters include glycols such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol and polypropylene glycol; fats and oils such as olive oil, castor oil, squalane and lanolin; and hydrocarbons such as liquid paraffin. Hydrogens; etc. In addition, an organic solvent or a surfactant that is liquid at room temperature can also be used. Further, the fatty acid ester contained in the pressure-sensitive adhesive composition may be compatible with the acrylic copolymer constituting the pressure-sensitive adhesive composition as a whole, and the fatty acid ester incompatible with the acrylic copolymer may be used. It may be contained.

In the present invention, when the liquid plasticizer contained in the pressure-sensitive adhesive composition used in the present invention is only a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and compatible with an acrylic copolymer. The content of the fatty acid ester having a molecular weight in the range of 350 or more and 550 parts or less in the pressure-sensitive adhesive composition used is preferably 1 part by mass or more and 35 parts by mass or less, more preferably 1 part by mass or less, based on 100 parts by mass of the acrylic copolymer. It is 5 parts by mass or more and 25 parts by mass or less, more preferably 10 parts by mass or more and 20 parts by mass or less. If this content is less than 1 part by mass, the plasticizer layer may be insufficiently plasticized and skin irritation may not be reduced. Conversely, if it exceeds 35 parts by mass, the pressure-sensitive adhesive may aggregate. The force may be reduced, leaving adhesive residue on the skin during peeling. When the molecular weight contained in the acrylic copolymer is in the range of 350 or more and 550 or less and the number of fatty acid esters compatible with the acrylic copolymer is two or more, "molecular weight in the pressure-sensitive adhesive composition". "Content of fatty acid ester in the range of 350 or more and 550 or less" is the total amount of fatty acid ester corresponding to the fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and compatible with the acrylic copolymer. means.

When the pressure-sensitive adhesive composition used in the present invention contains a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and compatible with an acrylic copolymer, and other liquid plasticizers, the present invention The content of the fatty acid ester having a molecular weight in the range of 350 or more and 550 or less is preferably 50% by mass or more, preferably 60% by mass or more, based on the total amount of the liquid plasticizer contained in the pressure-sensitive adhesive composition used in the present invention. Is more preferable, 80% by mass or more is further preferable, and 90% by mass or more is particularly preferable. Further, the weight average molecular weight of the entire liquid plasticizer contained in the pressure-sensitive adhesive composition, particularly, the weight average molecular weight of the entire fatty acid ester liquid at room temperature is preferably in the range of 350 or more and 550 or less.

(Additive)
The pressure-sensitive adhesive composition used in the present invention may contain various additives in addition to the cross-linking agent, if necessary. As the additive, it is commonly used in adhesives that form an adhesive layer provided in a patch, such as drugs, fillers, antioxidants (antioxidants, preservatives), colorants, fragrances, and tackifiers. Additives can be included. For example, a tackifier can be added to adjust the adhesive properties of the pressure-sensitive adhesive. Examples of the tackifier include terpene-based, terpene phenol-based, kumaron inden-based, styrene-based, rosin-based, xylene-based, phenol-based, and petroleum-based tackifier resins.

<Medical patch>
The medical patch according to the present invention includes a laminate of a support and an adhesive layer. The medical patch according to the present invention preferably has a pressure-sensitive adhesive layer made of the pressure-sensitive adhesive composition used in the present invention on at least one side of the support. Since the pressure-sensitive adhesive layer is formed by the pressure-sensitive adhesive composition, it is possible to suppress the peeling area of the keratin at the time of peeling while maintaining sufficient adhesive strength to human skin, and it can be continuously applied to the same part of the skin surface or A medical patch material that has little effect on skin irritation even when repeatedly applied can be obtained. Therefore, the medical patch according to the present invention is a patch that is repeatedly stuck to the same part of the skin such as for fixing a tube such as a catheter, or a specific skin such as a magnetic therapy device adhesive plaster or taping tape. It is suitable for a sticking material that is continuously or repeatedly stuck to a part.

(Support)
Support constituting the medical adhesive material according to the present invention, moisture permeability is more than 500g / m 2 · ^24h. By using a support having sufficient moisture permeability, it becomes a medical patch material having sufficiently high moisture permeability, less stuffiness when applied to the skin, and less likely to cause skin irritation or itching during application. The moisture permeability of the support, preferably at least 500g ^/ m 2 · 24h, more preferably 700g ^/ m 2 · 24h or more, still more preferably 1,000g ^/ m 2 · 24h or more, 1, more preferably more is at 500g ^/ m 2 · 24h or more, particularly preferably at 5,000g ^/ m 2 · 24h or more, and most preferably 20,000g ^/ m 2 · 24h or more.

Examples of the support include impregnated paper, coated paper, high-quality paper, kraft paper, Japanese paper, glassin paper, and other papers; polyester films such as polyethylene terephthalate and polybutylene terephthalate, polyolefin films such as polyethylene and polypropylene, and polyvinyl chloride. Plastic films such as films, polypropylene films, polyurethane films, cellophane films; foams; fabrics such as non-woven fabrics, woven fabrics, knitted fabrics; laminates of two or more of these; and the like. As the material of the fabrics, natural materials such as cotton, synthetic resin materials, recycled resin materials and various materials in which these are appropriately combined can be used. Among them, polyester, polyurethane, polyethylene, polypropylene, polyamide, acrylic resin, etc. Non-woven fabrics, woven fabrics, knitted fabrics, etc. made of cotton or the like can be used.

Moisture permeability of the support of the medical adhesive material according to the present invention is 500g ^/ m 2 · 24h or more. Therefore, as the support, fabrics such as non-woven fabric, woven fabric, and knitted fabric are preferable. Among them, a material that is flexible enough to adhere to the skin and can follow the movement of the skin, and a material that can suppress the occurrence of skin irritation after long-term application are preferable, and the skin under application is preferable. The woven fabric is preferable in that it has excellent followability to the movement of the surface, and further, it is easy to maintain the strength and the self-back surface adhesive force becomes stronger.

The thickness of the support can be appropriately selected in consideration of physical properties such as elongation, tensile strength, workability, feel at the time of application, and airtightness of the affected area, but is usually about 5 μm to 1 mm. When the thickness of the support is as thin as 5 μm or more and 30 μm or less, the carrier is placed on a surface opposite to one surface of the support provided with the adhesive layer (hereinafter referred to as the other surface). Layers may be provided.

When the support is a woven fabric, its thickness is preferably 50 μm or more and 1 mm or less, more preferably 100 μm or more and 800 μm or less, and further preferably 200 μm or more and 700 μm or less. The basis weight is preferably 400 g / m ² or less, more preferably 300 g / m ² or less, and further preferably 250 g / m ² or less from the viewpoint of followability to the skin.

When the support is a plastic film, its thickness is preferably 10 μm or more and 300 μm or less, more preferably 12 μm or more and 200 μm or less, and further preferably 15 μm or more and 150 μm or less. When the support is a film, sandblasting or corona treatment is performed on one side or the other side of the support, or both sides thereof, for the purpose of improving the anchoring property of the adhesive layer and the support. Etc. may be performed.

If the thickness of the support is less than 5 μm, the strength and handleability of the adhesive tape will decrease, making it difficult to attach it to the skin, tearing it due to contact with other members, or using it with water for bathing, etc. It may peel off from the skin in a short time due to contact. In addition, if the thickness of the support is too large (more than 1 mm), it becomes difficult for the adhesive tape to follow the movement of the skin, and it becomes easy to form a trigger for peeling at the edge of the adhesive tape, so that the adhesive tape peels off from the skin in a short time. There is a risk that the feeling of discomfort during pasting will increase.

(Adhesive layer)
The pressure-sensitive adhesive layer is formed by applying the pressure-sensitive adhesive composition used in the present invention to the surface of the support to a desired thickness and drying it. When the pressure-sensitive adhesive composition contains a cross-linking agent, a cross-linking treatment according to the type of the cross-linking agent such as an ultraviolet irradiation treatment is performed after coating.

The thickness of the pressure-sensitive adhesive layer in the medical patch according to the present invention is not particularly limited, and is preferably 1 μm or more and 200 μm or less, more preferably 10 μm or more and 100 μm or less, and further preferably 20 μm or more and 80 μm or less. The adhesive strength depends on the thickness of the adhesive layer. If the thickness of the adhesive layer is too thick, the adhesive strength becomes too high, and if the thickness of the adhesive layer is too thin, the adhesive strength becomes weak. By setting the thickness of the pressure-sensitive adhesive layer within the above range, in addition to being able to adhere to the skin with sufficient adhesive strength, the adhesive material can be adhered along the surface of the adherend having fine irregularities such as the skin. Furthermore, skin irritation can be suppressed low when peeled off after use.

(Career layer)
The medical patch according to the present invention may be temporarily attached to a support to form a carrier layer. For example, it can be a patch having a laminated structure of "carrier layer / support / adhesive layer / separator layer". The carrier layer can improve the film-forming property of the support, the handleability of the sticking material, and the stickability to the adherend when the thickness of the support is thin. Since the carrier layer is provided to improve the handleability of the sticking material, it may cover the entire surface of the sticking material, only the edge of the sticking material, or a pattern such as a grid pattern. It may be covered in a shape.

For the carrier layer, for example, a film made of various thermoplastic resins such as polyurethane, polyethylene, polypropylene, ionomer, polyamide, polyvinyl chloride, polyvinylidene chloride, ethylene vinyl acetate copolymer, thermoplastic polyester, and polytetrafluoroethylene is used. It is preferable to form it.

The various films may be laminated on paper. It is preferable that these carrier layers are thicker or stiffer than the support (for example, polyurethane elastomer film). The thickness of the carrier layer can be appropriately set, but is usually 10 μm or more, preferably 20 μm or more, and the upper limit thereof is about 500 μm.

(Separator layer)
In addition to the support layer and the pressure-sensitive adhesive layer, the medical patch according to the present invention is usually adjacent to the pressure-sensitive adhesive layer in order to protect the pressure-sensitive adhesive layer until the time when the pressure-sensitive adhesive layer is attached to the skin. A separator layer is provided.

The separator layer in the present invention is not particularly limited, and in the technical field of affixing materials, those generally used as release paper, release film, release paper, release film, release liner and the like can be used. .. Specific examples thereof include a polyethylene terephthalate film whose surface is treated with silicone, a laminate of polyethylene whose surface is treated with silicone, and paper. Further, the separator layer may be provided with a cut in order to improve handleability (that is, releasability from the pressure-sensitive adhesive layer), may be formed in a larger area than the sticking material, and a grip portion may be provided on the peripheral edge portion. Good. Further, the separator layer may be provided with irregularities by sandblasting or the like on the surface of the separator layer facing the adhesive layer or the surface opposite to the adhesive layer for the purpose of improving handleability and printability. Good.

The thickness of the separator layer can be appropriately set and is not particularly limited, but is usually 20 μm or more, preferably 40 μm or more, and the upper limit thereof is about 500 μm.

(Humidity permeability)
Medical patch according to the present invention, it is preferred moisture permeability is at 500g ^/ m 2 · 24h or more. The patch is, moisture permeability that is 500g / m 2 · ^24h or more, less stuffiness when applied to the skin, hardly occurs itchy skin irritation or sticking in. Moisture permeability of the patch, it is more preferably 700g ^/ m 2 · 24h or more, more preferably 1,000g ^/ m 2 · 24h or more, 1,500g ^/ m 2 · 24h or more There still more preferably, particularly preferably at 5,000g ^/ m 2 · 24h or more, and most preferably 20,000g ^/ m 2 · 24h or more. Moisture permeability higher preferably, the upper limit is not particularly preferred moisture permeability is usually at most 30,000g ^/ m 2 · 24h. In the present invention, the moisture permeability is measured at a temperature of 40 ° C. and a relative humidity of 90% according to the B condition of JIS Z0208. That is, the temperature on one side of the patch is adjusted to 40 ° C. and the relative humidity is 90%, and a moisture absorbent such as calcium chloride is placed on the other side to absorb the moisture that has passed through the patch, and the amount of change in the weight of the moisture absorbent. Is calculated by converting to 24 hours per 1 m ² .

(Adhesive force)
The adhesive strength of the medical patch according to the present invention is preferably 0.5 N / 25 mm or more and 12.0 N / 25 mm or less, more preferably 2.0 N / 25 mm or more and 8.0 N as the adhesive force (peeling force) against bakelite. It is preferably within the range of / 25 mm or less. Since the adhesive strength of the medical patch is within this range, when the medical patch according to the present invention is stuck on the skin surface, it has sufficient sticking performance, does not cause misalignment during sticking, and is said to be relevant. When peeling off the patch, there is no risk of peeling off the skin surface or causing a rash.

The method for measuring the adhesive strength of the medical patch is as follows. That is, the sticking material is cut into a predetermined length of 25 mm in width × 15 mm in length or more, preferably 100 mm to obtain a test piece. The test piece is pressed against a Bakelite test panel to be attached, and then attached with a 2 kg roller at a crimping speed of 300 mm / min and one reciprocating crimping frequency to prepare a test piece. After 20 minutes have passed since the application, the adhesive strength is applied under the conditions of a peeling angle of 180 ° and a peeling speed of 300 mm / minute in accordance with the peeling adhesive strength test method of ISO29862 method 1 (corresponding JIS: JIS Z0237). Measure.

(Manufacturing method of medical patch material)
The method for producing the medical patch according to the present invention is not particularly limited. For example, it is preferable to adopt a method of applying a pressure-sensitive adhesive solution on a separator layer generally used as a so-called release liner and drying it to form a pressure-sensitive adhesive layer. As a method for continuously forming the pressure-sensitive adhesive layer, a method in which the pressure-sensitive adhesive solution is applied onto the separator layer while running in one direction and dried is preferable. A method of melting the adhesive and applying it on the separator layer may be adopted. It can also be a repeating pattern coating of a specific shape.

Lamination of "support / adhesive layer / separator layer" by adhering a laminate having an adhesive layer formed on one side of the separator layer and a support so that the adhesive layer and the surface of the support are in close contact with each other. A patch having a structure can be produced. Further, in the case of a laminated body in which a carrier layer which is an arbitrary layer is formed on one side of the support, the adhesive layer and the surface of the support of the laminated body are bonded so as to be in close contact with each other to form a “carrier layer (arbitrary layer)”. A patch material having a laminated structure of "/ support / adhesive layer / separator layer" can be produced.

Next, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to the following Examples.

[Examples 1 to 4, Comparative Examples 1 to 7]
A pressure-sensitive adhesive composition containing various liquid plasticizers was prepared, and the adhesive strength and the effect on human skin of the adhesive material on which the pressure-sensitive adhesive layer was formed were investigated. As the liquid plasticizer, methyl oleate (molecular weight: 296.5), isopropyl myristate (molecular weight: 268.0), glyceryl monooleate (molecular weight: 356.0), sorbitan monooleate (molecular weight: 428.6). ), Oleyl oleate (molecular weight: 531.0), isostearyl isostearate (molecular weight: 537.0), soybean oil (molecular weight: about 880, SR soybean-LQ- (JP), manufactured by Claude Japan), triolein Polysorbate acid (molecular weight: 935.0), castor oil fatty acid ester (molecular weight: about 500, Ricksizer C-101, manufactured by Ito Oil Co., Ltd.), decyl oleate (molecular weight: 422.4), special castor oil-based condensed fatty acid (molecular weight: 422.4) Molecular weight: 800, Minerazole, manufactured by Ito Oil Co., Ltd.) was used. As the support, woven (warp: corespun, weft: cotton, moisture permeability: 21,060g ^/ m 2 · 24h, basis weight 155 g ^{/ m} 2), urethane nonwoven (fiber diameter: 15 [mu] m, moisture permeability: 21, 590g ^/ m 2 · 24h, basis weight 65g ^{/ m} 2), polyethylene film (thickness: 50 [mu] m, moisture permeability: ^60g / m 2 · 24h) was used.

<Sample preparation>
First, as a pressure-sensitive adhesive composition, an acrylic copolymer obtained by copolymerizing a monomer mixture composed of 2-ethylhexyl ester of acrylic acid / vinyl acetate / acrylic acid = 85/11/4 (mass ratio). The liquid plastic agents shown in Tables 1 to 3 were mixed with 100 parts by mass of the acrylic copolymer in the solution of the above so as to have the parts by mass shown in Table 1, and Tetrad-X (Mitsubishi Gas) was further used as a cross-linking agent. A uniform solution of the pressure-sensitive adhesive composition was prepared by mixing 0.06 parts by mass (manufactured by Kagaku Co., Ltd.).
The solution of this pressure-sensitive adhesive composition was applied to the peel-treated surface of the separator (silicone-treated polylami release paper) so that the thickness after drying was 38 μm, and dried to form a pressure-sensitive adhesive layer. This pressure-sensitive adhesive layer was bonded to the supports shown in Tables 1 to 3 to prepare a patch.

<Measurement of adhesive strength to human skin>
A test sample having a size of 15 mm × 70 mm was attached to the forearm of a human subject. Twenty-four hours after application, the adhesive strength (N / 15 mm) was measured using an Instron type tensile tester under the conditions of a peeling speed of 100 mm / min and a peeling angle of 90 ° (n = 8). The peeling was performed from the little finger side to the thumb side. The measurement results are shown in Tables 1 to 3.

<Measurement of exfoliated area ratio>
Each test sample after being peeled off in the above-mentioned adhesive strength measurement was stained with cation staining (Gentian violet: 1.0%, Brilliant green: 0.5%, Distilled water: 98.5%) and then under running water. Washed with. The stained test sample was imaged under a microscope (VHX-1000: VH-Z100UR, manufactured by KEYENCE), and the obtained image was analyzed by an image processing device (Win ROOF, manufactured by Mitani Shoji Co., Ltd.). The area of keratinocytes attached to the test sample was measured. For each test sample, the keratinocyte attachment area ratio ([keratinocyte attachment area] / [surface area of the test sample] × 100 (%)) of three visual fields was calculated, and this average value was taken as the keratin exfoliation area ratio of each test sample. (N = 8). The measurement results are shown in Tables 1 to 3.

<Residual adhesive>
In the above-mentioned adhesive strength measurement, it was visually confirmed whether or not the adhesive remained on the skin surface after each test sample was peeled off (n = 8). The results are shown in Tables 1 to 3. In the table, "x" indicates that the adhesive remained on the skin at the time of peeling, and "○" indicates that the adhesive did not remain on the skin at the time of peeling.

<Repeated forearm sticking test>
A repeated forearm attachment test (up to 7 days) in which the test sample is attached to the surface of human skin, peeled off every 24 hours, the skin reaction after 1 hour is confirmed, and then a new test sample of the same type is attached to the same site. , 7 test samples were used per test group) (n = 9). Skin reactions were 1 hour and 24 hours after exfoliation (test end date): 5: no reaction, 4: mild erythema, 3: erythema, 2: erythema + edema, 1: erythema + edema + papules. , Or with vesicles, 0: with large erythema. The results are shown in Tables 1 to 3.

Comparing Examples 1 to 6 and Comparative Examples 1 to 8 in which the supports are the same, the adhesive strength of each test sample to human skin is 10 parts by mass of the fatty acid ester with respect to 100 parts by mass of the acrylic copolymer. In the test sample containing 20 parts by mass or 20 parts (Comparative Examples 2 to 3, Examples 1 to 6, Comparative Examples 5 to 8), the numerical value was higher than that of the test sample not containing the fatty acid ester (Comparative Example 1). Yes, the adhesive strength could be enhanced by blending the fatty acid ester. In the test sample (Comparative Example 4) in which 30 parts by mass of the fatty acid ester was mixed with 100 parts by mass of the acrylic copolymer, adhesive residue was generated at the time of peeling. It was presumed that this was because the content of the liquid plasticizer was high and the adhesive layer became too soft. On the other hand, the test sample (Comparative Example 7) in which decyl oleate, which is inferior in compatibility with the acrylic copolymer, was selected, had adhesive residue in the adhesive residue test, which caused a problem as a medical patch. It was something.

The exfoliation area ratio of each test sample was compared with Comparative Example 1 in the test samples (Examples 1 to 6) containing a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and having good compatibility with the acrylic copolymer. The keratin exfoliation area ratio was about 40%, which was sufficiently low. On the other hand, in the test samples (Comparative Example 2, Comparative Examples 5, 6 and 8) containing fatty acid esters having a molecular weight outside the range, the keratin exfoliation area ratio is 50% or more, and the reduction effect is small. I was able to confirm that. In addition, 15 parts by mass of isopropyl myristate (molecular weight: 268.0) whose molecular weight is out of the range as a liquid plasticizer and 5 parts by mass of oleyl oleate (molecular weight: 531.0) whose molecular weight is within the range. In the test sample of Comparative Example 3 in which the weight average molecular weight of the liquid plastic agent is 333.8 [(268.0 × 15 + 531.0 × 5) / (15 + 5)], the molecular weight is within the range. Similar to the test sample containing only the detached fatty acid ester, the keratin exfoliation area ratio was 50% or more, and the reduction effect was small.

As for the skin reaction, the test samples (Examples 1 to 6) containing a fatty acid ester having a molecular weight in the range of 350 or more and 550 or less and having good compatibility with the acrylic copolymer were almost in a skin state over time. It was confirmed that the amount was maintained without decreasing. In addition, it was confirmed that few subjects remained reddish even 24 hours after the peeling on the end date of the test. On the other hand, different test samples (Example 3, 7, Comparative Example 9) only supports a comparison of Example moisture permeability has a urethane nonwoven fabric is 500g / m 2 · ^24h or more and the support 7, the moisture permeability Comparative example 500 g / m 2 · but ^24h the at is woven more was example 3 and comparable without evaluation result of the support, the moisture permeability was polyethylene film is 60 g / m 2 · ^24h and the support In No. 9, although the keratin thin area ratio was low, the human skin adhesive strength was significantly reduced and the skin reaction was also strong. These results, moisture permeability of the woven or nonwoven fabric is 500g / m 2 · ^24h or more as a support for the pressure-sensitive adhesive layer including the acrylic copolymer, the compatibility with the acrylic copolymer By blending an appropriate amount of a fatty acid ester having a good molecular weight of 350 or more and 550 or less, a pressure-sensitive adhesive layer with low skin irritation is formed even when continuously or repeatedly applied to the same part of the skin while maintaining high adhesive strength. It is clear that it can be done.

Claims

A medical patch having a laminate of a support and an adhesive layer.
The pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive composition containing a copolymer containing a (meth) acrylic acid alkyl ester as a main component and a fatty acid ester compatible with the copolymer which is liquid at room temperature.
The weight average molecular weight of the fatty acid ester contained in the pressure-sensitive adhesive composition is 350 or more and 550 or less.
The pressure-sensitive adhesive composition contains 5 parts by mass or more and 25 parts by mass or less of the fatty acid ester with respect to 100 parts by mass of the copolymer.
The moisture permeability of the support is 500g / m 2 · 24h or more,
Medical patch material.
The medical patch according to claim 1, wherein the fatty acid ester contains a single type of fatty acid ester having a weight average molecular weight of 350 or more and 550 or less.
In the copolymer, acrylic acid alkyl ester having an alkyl group having 8 or more and 12 carbon atoms is 65% by mass or more and 90% by mass or less, acrylic acid is 2% by mass or more and 15% by mass or less, and vinyl acetate is 5. A claim in which a copolymer obtained by polymerizing a copolymer of 0% by mass or more and 25% by mass or less and 0% by mass or more and 10% by mass or less of other vinyl monomers by a solution polymerization method is crosslinked with a cross-linking agent. The medical patch according to 1 or 2.
The medical patch according to any one of claims 1 to 3, wherein the fatty acid ester has at least one oleic acid residue.
The medical patch according to claim 4, wherein all the fatty acid residues in the fatty acid ester are oleic acid residues.
The medical patch according to any one of claims 1 to 5, further comprising a separator layer on a surface of the adhesive layer opposite to the surface in contact with the support.
The medical patch according to any one of claims 1 to 6, which is repeatedly applied to the same part of the skin.
The medical patch according to any one of claims 1 to 7, which is for fixing a tube.