JP2009261727A - Medical self-adhesive composite and self-adhesive tape or sheet - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical self-adhesive composite and a self-adhesive tape or sheet made of this composite, having excellent fixability or cohesive power, as well as the balanced control of physical stimulations arising from horny layer ablation, etc., when the tape or sheet is peeled off from the skin, and containing no organic solvent in consideration of environmental hygiene, and further to provide a medical self-adhesive composite containing no organic solvent in consideration of environmental hygiene, and a self-adhesive tape or sheet manufactured from the medical self-adhesive composite. <P>SOLUTION: The medical self-adhesive composite comprises an aqueous dispersion type copolymer obtained by aqueous dispersion type copolymerization of a monomer mixture containing an alkyl acrylate, (meth)acrylic acid and an alkyl methacrylate, a nonionic surface-active agent with the HLB of 10 or more, and a cross linker. The self-adhesive tape or sheet has a self-adhesive layer of this medical self-adhesive composite formed on the one surface of its support material. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a medical pressure-sensitive adhesive composition used for application to skin in the medical and hygiene field, and a pressure-sensitive adhesive tape or sheet using the composition, and more specifically, alkyl acrylate and (meth) acrylic. A non-ionic surfactant having a hydrophile-lipophile balance (HLB) of 10 or more is added to a water-dispersed copolymer obtained by water-dispersing copolymerization of a monomer mixture containing an acid and an alkyl methacrylate. The present invention relates to a medical pressure-sensitive adhesive composition and a pressure-sensitive adhesive tape or sheet comprising the composition, which is contained as a liquid component and has an appropriate amount of crosslinking treatment applied to the copolymer.

  Conventionally, medical pressure-sensitive adhesive tapes and sheets using various medical pressure-sensitive adhesives have been developed for protecting affected skin areas, transdermally absorbing drugs, or fixing gauze, tubes and the like to the skin. The nature of medical adhesive tapes and sheets is that they are often applied directly to the skin, so the ability to fix a tube with adhesive or repulsive force to the skin is required, and at the same time peeling There is a need for a device that reduces physical irritation to the skin, such as exfoliation of the skin.

  As the pressure-sensitive adhesive used for the pressure-sensitive adhesive layer such as a pressure-sensitive adhesive tape or sheet, a pressure-sensitive adhesive made of a (meth) acrylic acid ester-based polymer having excellent adhesion and moisture permeability and less chemical irritation to the skin is generally used. Has been used. However, adhesives made of (meth) acrylic acid ester polymers have strong adhesive strength, which can cause pain when the adhesive tape or sheet is peeled from the skin or damage the stratum corneum or epidermis of the skin. There was a thing. In particular, when an adhesive tape or the like is repeatedly applied to the same site, skin damage such as bleeding may occur, which may be a serious problem.

  In order to reduce such physical irritation to the skin, a (meth) acrylic acid ester polymer contains a large amount of an organic liquid component compatible with the polymer, and is subjected to a crosslinking treatment to form a gel. Proposed adhesives have been proposed (Patent Document 1, Patent Document 2). With respect to such a pressure-sensitive adhesive, it is possible to relax and disperse the stress applied to the skin surface at the time of peeling while maintaining the high adhesiveness of the (meth) acrylic acid ester-based polymer. Therefore, since physical irritation to the skin is small and exfoliation of the keratin is reduced, it is applied to a transdermal absorption tape preparation and a medical surgical tape. However, the pressure-sensitive adhesive tape obtained by laminating the pressure-sensitive adhesive disclosed there on a support film is not sufficiently fixed when used for fixing a medical tube to the skin, and is particularly resistant in the summer when sweating is severe. The decrease in sweat fixation was noticeable. Moreover, since the said medical adhesive was produced in the organic solvent, there also existed a problem that it was unpreferable on environmental health.

In addition, a medical pressure-sensitive adhesive composition has been developed that is composed of a water-dispersed pressure-sensitive adhesive composition and has an excellent balance between adhesiveness to the skin and no adhesive residue on the skin when peeled (Patent Document) 3). However, when this adhesive composition contains a compatible organic liquid component, adhesive properties such as fixability and cohesive strength are not sufficiently expressed, and as a result, balance with suppression of physical irritation such as exfoliation of the keratin is balanced. It was difficult to take.
JP-A-6-23029 JP-A-6-319793 JP 2003-064336 A

  In view of the above circumstances, the problem to be solved by the present invention is a balance with suppression of physical irritation accompanied by exfoliation and the like when exfoliating from the skin and having good adhesiveness, fixability and cohesive force. Another object of the present invention is to provide a medical pressure-sensitive adhesive composition that can be produced without using an organic solvent in consideration of environmental hygiene and a pressure-sensitive adhesive tape or sheet using the composition. Furthermore, an object of the present invention is to provide a medical pressure-sensitive adhesive composition that can be produced without using an organic solvent in consideration of environmental hygiene, and a pressure-sensitive adhesive tape or sheet using the composition. is there.

  In order to solve the above-mentioned problems, the present inventors have made a water-dispersed monomer mixture containing an alkyl acrylate ester, a (meth) acrylic acid alkyl ester and a methacrylic acid alkyl ester for a composition used as a medical pressure-sensitive adhesive. A medical pressure-sensitive adhesive obtained by blending a water-dispersed copolymer obtained by copolymerization with a nonionic surfactant having an HLB of 10 or more as a liquid component, and further appropriately crosslinking the copolymer. The composition has excellent balance of adhesion, fixability and cohesive force, which has been difficult to achieve in the past, and has properties that can reduce physical irritation such as exfoliation when exfoliating from the skin, It discovered that it could manufacture without using an organic solvent, and completed this invention.

That is, the present invention is as follows.
(1) A water-dispersed copolymer obtained by water-dispersing copolymerization of a monomer mixture containing an alkyl acrylate, (meth) acrylic acid, and a methacrylic acid alkyl ester, and an HLB of 10 or more A medical pressure-sensitive adhesive composition containing a nonionic surfactant and a crosslinking agent.
(2) The medical pressure-sensitive adhesive composition according to (1), wherein the content of the nonionic surfactant having an HLB of 10 or more is 20 to 60 parts by weight with respect to 100 parts by weight of the water-dispersed copolymer. object.
(3) The medical pressure-sensitive adhesive composition according to (1) or (2), wherein the alkyl group of the acrylic acid alkyl ester has 4 to 12 carbon atoms and the alkyl group of the methacrylic acid alkyl ester has 1 to 4 carbon atoms. object.
(4) Any one of the above (1) to (3), wherein the water-dispersed copolymer is obtained by performing emulsion polymerization in the presence of an emulsifier, a chain transfer agent and a polymerization initiator. The adhesive composition for medical use according to 1.
(5) An adhesive tape or sheet obtained by forming an adhesive layer made of the medical adhesive composition according to any one of (1) to (4) on a support.

  The medical pressure-sensitive adhesive composition of the present invention, when applied and used on the skin as an adhesive tape or sheet, provides a good fixability and cohesive force, and at the same time is physically associated with exfoliation when peeling from the skin. Since it has the characteristic which was excellent in balance with suppression of irritation | stimulation, it can be set as an adhesive tape and a sheet | seat suitable for medical hygiene materials uses, such as an emergency adhesive bandage, a wound bond, a dressing material, and a drape material. Furthermore, the medical pressure-sensitive adhesive composition of the present invention can be manufactured without using an organic solvent in consideration of environmental hygiene.

  Hereinafter, although this invention is demonstrated in detail with desirable embodiment, this invention is not limited to these aspects.

  In the present invention, the term “medical use” refers to those widely used in the medical and hygiene fields, and is used for application to skin. Examples thereof include those for blending a drug for percutaneous absorption, those for protecting the affected area of the skin, and those for fixing medical and hygiene materials such as gauze and tubes.

  The medical pressure-sensitive adhesive composition of the present invention is a non-ionic surfactant having an HLB of 10 or more (preferably a non-ionic liquid that exhibits a liquid state at room temperature) to a water-dispersed copolymer obtained from a specific monomer mixture. System surfactants) and an appropriate cross-linking treatment to the copolymer.

  The copolymer constituting the medical pressure-sensitive adhesive composition of the present invention is a water-dispersed type, and a water-dispersed copolymerization of a monomer mixture containing an alkyl acrylate, (meth) acrylic acid and an alkyl methacrylate. Can be obtained.

  As an alkyl acrylate ester, for example, an alkyl group having an alkyl group having 4 to 12 carbon atoms such as a butyl group, a pentyl group, a hexyl group, a nonyl group, an octyl group, a decyl group, or a dodecyl group is used. These alkyl groups may be linear or branched. Particularly preferred as the alkyl acrylate ester are 2-ethylhexyl acrylate and isooctyl acrylate.

  As the alkyl methacrylate ester to be copolymerized with the alkyl acrylate ester, an alkyl group having, for example, an alkyl group having 1 to 4 carbon atoms such as a methyl group, an ethyl group, a propyl group, a butyl group, or an isobutyl group bonded thereto is bonded. These alkyl groups may be linear or branched. Particularly preferred as the alkyl methacrylate is methyl methacrylate.

  The blending amount of each monomer is 1 to 5 parts by weight for (meth) acrylic acid and 3 to 20 parts by weight for alkyl methacrylate, per 100 parts by weight of alkyl acrylate.

  When the blending amount of (meth) acrylic acid is less than 1 part by weight, the tackiness is insufficient, and when it exceeds 5 parts by weight, the adhesion to the skin and the fixability tend to be unfavorable. On the other hand, when the blending amount of the methacrylic acid alkyl ester is less than 3 parts by weight, the glass transition temperature of the copolymer is lowered and the adhesiveness and fixability are improved. In addition, there is a risk of generating adhesive residue on the skin. On the other hand, when the amount exceeds 20 parts by weight, the cohesive force is improved with an increase in the glass transition temperature, but when it peels from the skin, a stick-slip phenomenon is caused and physical irritation may increase.

  The water-dispersed copolymer can be obtained by emulsion polymerization in the presence of an emulsifier, a chain transfer agent, and a polymerization initiator, and the amount of the emulsifier, the chain transfer agent, and the polymerization initiator is adjusted appropriately. Can do.

  The emulsifier, the chain transfer agent, and the polymerization initiator are not particularly limited, but are excellent in stability and reproducibility of emulsion polymerization, and have no chemical irritation or toxicity even when remaining on human skin. Are preferred.

  The method of emulsion polymerization is not particularly limited, and conventionally known emulsion polymerization methods such as a batch charging method, a monomer sequential addition method, a seed polymerization method, and an emulsion monomer sequential addition method can be employed.

  In the case of emulsion polymerization, an anionic emulsifier (sodium sulfosuccinate, ammonium lauryl sulfate, sodium polyoxyethylene alkylphenyl ether sulfate is used as an emulsifier in consideration of maintenance of dispersion stability of the monomer mixture in water medium and polymerization stability. Nonionic emulsifiers (polyoxyethylene alkyl ether, polyoxyalkylphenyl ether, etc.), cationic emulsifiers (alkyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.), and unsaturated groups (for example, propenyl, for example) A reactive emulsifier imparted with a radically polymerizable group such as a group or an allyl group) can be used, and these can be used alone or in combination of two or more. Among these, from the viewpoint of stability, it is preferable to use an anionic emulsifier, a nonionic emulsifier, or a reactive emulsifier. The amount of the emulsifier is 0.3 to 2 parts by weight with respect to 100 parts by weight of the monomer mixture.

  As the chain transfer agent, lauryl mercaptan, 2-mercaptoethanol, thioglycolic acid, or the like can be used, and the amount thereof is 0.02 to 0.1 parts by weight with respect to 100 parts by weight of the monomer mixture. .

  The molecular weight of the resulting copolymer can be adjusted by the type and blending amount of the chain transfer agent, but is not limited to the adjustment of the chain transfer agent alone, and can also be adjusted by the polymerization temperature, the polymerization time, and the like.

  As the polymerization initiator, persulfates, organic peroxides, redox compounds, azo compounds, etc., which are already known for use in emulsion polymerization, can be used, and the blending amount thereof is monomer mixture 100. It is 0.05-0.5 weight part with respect to a weight part.

  The preparation of the water-dispersed copolymer is carried out by stirring and mixing an emulsifier, chain transfer agent, polymerization initiator, etc. in the monomer mixture in an aqueous medium, the polymerization temperature during emulsion polymerization, the dropping rate of the emulsion monomer, and the stirring speed. This can be done by controlling the above.

  The nonionic surfactant which is a liquid component constituting the medical pressure-sensitive adhesive composition of the present invention has an HLB of 10 or more. Examples of the surfactant include polyhydric alcohol ethylene oxide (EO) adducts (polyoxyethylene sorbitan monolaurate (4EO), polyoxyethylene sorbitan monolaur, which are generally used as nonionic surfactants). Rate (20EO), polyoxyethylene sorbitan monopalmitate (20EO), polyoxyethylene sorbitan monostearate (20EO), polyoxyethylene sorbitan monooleate (5EO), polyoxyethylene sorbitan monooleate (20EO), polyoxyethylene Triolate (20EO), etc.), polyethylene glycol monoester (polyethylene glycol (400) monolaurate, polyethylene glycol (600) monolaurate, polyethylene glycol (1 00) monolaurate, polyethylene glycol (400) monostearate, polyethylene glycol (600) monostearate, polyethylene glycol (1000) monostearate, polyethylene glycol (400) monolaurate, polyethylene glycol (600) monolaurate , Polyethylene glycol (1000) monolaurate, etc.), polyethylene glycol diester (polyethylene glycol (600) dilaurate, polyethylene glycol (1000) dilaurate, polyethylene glycol (1540) dilaurate, polyethylene glycol (600) distearate, polyethylene glycol (1000) distearate , Polyethylene glycol (1540) distearate, polyethylene glycol Cole (600) diolate, polyethylene glycol (1000) diolate, polyethylene glycol (1540) diolate, etc.), higher alcohol ethylene oxide adducts (polyoxyethylene lauryl alcohol (5EO), polyoxyethylene lauryl alcohol (10EO), polyoxyethylene Lauryl alcohol (23EO), polyoxyethylene oleyl alcohol (10EO), polyoxyethylene oleyl alcohol (20EO), polyoxyethylene maccoal alcohol (7EO), polyoxyethylene maccoal alcohol (11EO), polyoxyethylene maccoal alcohol (14EO) , Polyoxyethylene maccoal alcohol (18EO), polyoxyethylene maccoal alcohol (24EO), etc.) , Alkylphenol ethylene oxide adducts (polyoxyethylene nonylphenol (6EO), polyoxyethylene nonylphenol (7EO), polyoxyethylene nonylphenol (10EO), polyoxyethylene nonylphenol (12EO), polyoxyethylene nonylphenol (14EO), polyoxyethylene Nonylphenol (16EO), polyoxyethylene nonylphenol (20EO), polyoxyethylene nonylphenol (40EO), etc.) and the HLB is 10 or more depending on the number of hydrophobic groups and the amount of hydrophilic groups such as ethylene oxide and polyethylene glycol. It will be.

  Preferably, the adhesive tape or sheet has a good adhesion and fixing property to the skin in practical use, and has an excellent balance with the cohesive force of the adhesive composition for reducing adhesive residue at the time of peeling. Is 14 or more.

  The upper limit value of the HLB of the nonionic surfactant is not particularly limited, but is preferably 16 or less, more preferably 15 or less.

  When the HLB is 5 or more and less than 10, when mixed with a water-dispersed copolymer, separation of the water dispersion or coagulation of the copolymer occurs, and subsequent coating tends to be difficult. When the HLB is less than 5, mixing with a water-dispersed copolymer is possible, but it is difficult to obtain good characteristics such as fixability after film formation. On the other hand, if the HLB exceeds 16, the hydrophilicity becomes too high and the compatibility with the water-dispersed polymer tends to be poor, and it becomes difficult to obtain a uniform coating (adhesive layer).

  When the amount of the nonionic surfactant is too small, the physical irritation at the time of peeling after applying it to the skin as an adhesive tape or sheet tends to be large, and as a result, it becomes difficult to suppress keratin peeling. If the amount is too large, the liquid component retention capacity of the copolymer will be exceeded, and the non-ionic surfactant as a liquid component will bloom from the adhesive layer of the adhesive tape or sheet to contaminate the adherend. As a result, it becomes difficult to obtain desirable characteristics.

  Accordingly, the nonionic surfactant is contained in an amount of 20 to 60 parts by weight, preferably 30 to 50 parts by weight, based on 100 parts by weight of the water-dispersed copolymer.

  The method for the crosslinking treatment is not particularly limited. For example, a water-soluble / oil-soluble epoxy-based crosslinking agent, an oxazoline crosslinking agent, or the like is used. These are blended in a water-dispersed state, and the water-dispersed copolymer can be crosslinked by heat drying when forming the medical pressure-sensitive adhesive composition on the pressure-sensitive adhesive layer. The amount of the crosslinking agent is 0.05 to 1 part by weight, preferably 0.1 to 0.5 part by weight, more preferably 0.2 to 0.00 part by weight based on 100 parts by weight of the water-dispersed copolymer. 4 parts by weight.

  The degree of crosslinking is adjusted in the range of 20 to 450 minutes, for example, if the load is a holding force of 300 g. In this case, if the holding force is less than 20 minutes, there is a tendency for adhesive residue or the like to be generated on the adherend when the tape is peeled off, and if it exceeds 450 minutes, it may be difficult to obtain sufficient skin adhesiveness or fixability.

  The medical pressure-sensitive adhesive composition of the present invention is formed on the support, preferably on one side thereof, with a pressure-sensitive adhesive layer usually having a thickness of 10 to 100 μm, preferably 20 to 80 μm, and is formed on the entire surface or partially in the form of dots or streaks. The pressure-sensitive adhesive tape or sheet of the present invention is used. In that case, you may apply | coat and dry directly to a support body, and you may affix on a support body, after once apply | coating and drying on a release paper.

  Supports used include various plastic films such as polyethylene, polypropylene, ethylene / vinyl acetate copolymer, polyester, polyvinyl chloride, and polyurethane, woven fabric, knitted fabric, non-woven fabric, paper, metal foil, or a laminate of these Etc. can be used. If it uses for a medical hygiene material use, there will be no restriction | limiting in particular in a shape, For example, it can process and use suitably for an emergency sticking plaster, a wound bond, a dressing material, a drape material, etc.

  EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the examples described below.

Example 1
In a reaction vessel equipped with a cooling pipe, a nitrogen introduction pipe, a thermometer and a stirrer, 94 parts by weight of distilled water, 0.88 parts by weight of an emulsifier (surfactant, Kao: trade name Latemul S180A), 2-ethylhexyl acrylate A blending of 93 parts by weight, 2 parts by weight of acrylic acid, 10 parts by weight of methyl methacrylate, 0.05 parts by weight of lauryl mercaptan as a chain transfer agent, and 0.1 parts by weight of ammonium persulfate as a polymerization initiator at a polymerization temperature of 70 ° C. The reaction was allowed to proceed for about 4.5 hours by the sequential addition method of the emulsified monomer, followed by aging at 86 ° C. for 2 hours to complete the reaction to obtain a water-dispersed copolymer.

  For 100 parts by weight of the obtained water-dispersed copolymer, 40 polyoxyethylene sorbitan monooleate (20EO) (HLB15) as a nonionic surfactant that is a polyhydric alcohol ester ethylene oxide adduct is used as a liquid component. In the present invention, 0.2 part by weight of tris (2,3-epoxypropyl) isocyanurate (Nissan Chemical Industries: trade name: TEPIC-S), which is a water-soluble epoxy crosslinking agent, is mixed and stirred as a crosslinking agent. The medical adhesive composition was obtained.

This medical pressure-sensitive adhesive composition is applied to the silicone-treated surface of a release paper that has been silicone-treated on one side so that the thickness of the pressure-sensitive adhesive layer after drying is 40 μm, dried, and then mixed with pulp / polyester fiber as a support. The pressure-sensitive adhesive tape of the present invention was obtained by bonding to a nonwoven fabric (basis weight 23 g / m ² ).
Examples 2 and 3

Two types of medical pressure-sensitive adhesive compositions and pressure-sensitive adhesive tapes were obtained in the same manner as in Example 1 except that the type of nonionic surfactant to be blended as a liquid component was changed as shown in Table 1.
Comparative Examples 1-3

  Two types of medical pressure-sensitive adhesive compositions and pressure-sensitive adhesive tapes were obtained in the same manner as in Example 1 except that the type of nonionic surfactant to be blended as a liquid component was changed as shown in Table 1. In the formulation of Comparative Example 3, the prepared pressure-sensitive adhesive composition was in an aggregated state, so that subsequent film formation became difficult, and the tests described below were not possible.

Experimental example 1

  In Examples 1 to 3 and Comparative Examples 1 to 3, the mixed liquid state after mixing each liquid component was confirmed (Table 1).

As is clear from the results shown in Table 1, the state of the liquid mixture changes depending on the HLB of the nonionic surfactant that is a liquid component. In Comparative Example 3, a uniform film could not be obtained.
Experimental example 2

The compounded liquid obtained in each Example and Comparative Example was formed into a film, and the adhesive pressure, fixability, cohesive strength, and keratin exfoliation amount were tested in the following manner using the produced adhesive tape. These results are as shown in Table 2.
[Measurement of adhesive strength]
The adhesive tape sample cut to a width of 12 mm was pressure-bonded to the bakelite plate by reciprocating a roller with a weight of 2 kg. After 30 minutes, the peel strength when peeled at a peel angle of 180 degrees and a peel speed of 300 mm / min was taken as the adhesive strength.
[Measurement of fixation]
A collagen membrane was fixed to a bakelite plate with double-sided tape, and a sample of an adhesive tape cut to a width of 12 mm was crimped on the collagen membrane surface by reciprocating a roller with a weight of 2 kg. After 30 minutes, a load of 15 g was applied at a peeling angle of 90 degrees, and the peeling speed was determined by dividing the peeling distance by time, and this was defined as fixability (constant load peeling). Under this measurement condition, it can be determined that a material having a thickness of 10 mm / h or less is excellent in fixability.
[Measurement of cohesive strength]
A pressure-sensitive adhesive tape sample cut to a width of 10 mm was pressed on a bakelite plate by reciprocating a 2 kg roller so that the length was 20 mm, and left at 40 ° C. for 20 minutes. Thereafter, a load of 300 g was applied in the shearing direction at 40 ° C., and the holding time until the sample dropped was measured and used as the cohesive force.
[Amount of exfoliation]
A sample of an adhesive tape having a width of 20 mm and a length of 60 mm was attached to the back of five panelists for 6 hours, and then peeled off at a peeling angle of 180 degrees and a peeling speed of 300 mm / min. The peeled sample was immersed in a keratin staining solution (purified water 98.5%, Gentian Violet 1.0%, Brilliant Green 0.5%) for 30 minutes, and then washed with tap water. The stained stratum corneum was magnified with a microscope, the stratum corneum area ratio in a fixed area was determined, and the average value of the six persons was defined as the amount of stratum corneum peeling.

  As is apparent from the results shown in Table 2, although the exfoliation amount of skin and the skin damage level in both Examples and Comparative Examples was almost the same, the adhesiveness, fixability, and cohesive strength The balance was different. As for the comparative example, the adhesiveness was relatively good when used as a pressure-sensitive adhesive tape, but the cohesive force was low and it was sticky, and the fixability was also low and the medical pressure-sensitive adhesive composition was unbalanced. The medical pressure-sensitive adhesive compositions of Examples 1 to 3 of the present invention have good fixability and cohesion when used as pressure-sensitive adhesive tapes, and suppress physical stimuli such as exfoliation when peeling from the skin. It was an excellent balance.

Claims (5)

  A water-dispersed copolymer obtained by water-dispersing copolymerization of a monomer mixture containing alkyl acrylate, (meth) acrylic acid, and alkyl methacrylate, and a nonionic system having an HLB of 10 or more A medical pressure-sensitive adhesive composition containing a surfactant and a crosslinking agent.   The medical pressure-sensitive adhesive composition according to claim 1, wherein the content of the nonionic surfactant having an HLB of 10 or more is 20 to 60 parts by weight with respect to 100 parts by weight of the water-dispersed copolymer.   The adhesive composition for medical use according to claim 1 or 2, wherein the alkyl group of the acrylic acid alkyl ester has 4 to 12 carbon atoms, and the alkyl group of the methacrylic acid alkyl ester has 1 to 4 carbon atoms.   The medical adhesive according to any one of claims 1 to 3, wherein the water-dispersed copolymer is obtained by emulsion polymerization in the presence of an emulsifier, a chain transfer agent, and a polymerization initiator. Composition.   The adhesive tape or sheet formed by forming the adhesive layer which consists of a medical adhesive composition of any one of Claims 1-4 on a support body.