WO2020208160A1 - Mindermengen-flüssigkeitsbehälter - Google Patents
Mindermengen-flüssigkeitsbehälter Download PDFInfo
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- WO2020208160A1 WO2020208160A1 PCT/EP2020/060198 EP2020060198W WO2020208160A1 WO 2020208160 A1 WO2020208160 A1 WO 2020208160A1 EP 2020060198 W EP2020060198 W EP 2020060198W WO 2020208160 A1 WO2020208160 A1 WO 2020208160A1
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- WO
- WIPO (PCT)
- Prior art keywords
- dimensionally stable
- liquid
- container
- liquid container
- container parts
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/06—Tubular
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/04—Seals
Definitions
- the invention relates to a small quantity liquid container for dispensing ei nes liquid medium in a bioprocessing system, in particular in a bioreactor, according to the preamble of claim 1, a packaging arrangement with a packaging and such a liquid container sterile packed therein according to claim 13 and the use of a Such a sterile packed liquid container and / or such a packaging arrangement according to claim 14.
- a bioprocess engineering system is understood here quite generally to mean a device with which biotechnological processes can be carried out or supported.
- Bioreactors in which microorganisms or tissue cells are cultivated under specified conditions, may be mentioned here merely as examples.
- Such a device usually has a container in which a biological reaction medium is made up of the substances intended for a biotechnological process, e.g. Microorganisms or tissue cells on the one hand and a corresponding nutrient medium on the other hand, is taken up in order to be able to carry out the respective biotechnological process step, for example fermentation or cultivation.
- a bioreactor is on the one hand a production bioreactor, i.e. a relatively large bioreactor on a production scale with a working volume of, for example, several 100 or several 1000 liters, for the industrial production of microbial or cellular products, in particular biopharmaceuticals.
- a bioreactor forms a fermentation broth as a product, which is usually treated further in a so-called downstream process in order to obtain a product from the cells or the culture supernatant.
- a laboratory bioreactor i.e. a relatively small bioreactor on a laboratory scale with a working volume of, for example, less than 10 liters.
- Such a laboratory bioreactor is used, for example, to produce ATMPs (Advanced Therapy Medical Products) and / or to carry out cell expansion through which a sufficient number of cells, in particular tissue cells or microbial cells, is generated for the respective application can be.
- ATMPs Advanced Therapy Medical Products
- One application for this is the reproduction of human cells, for example wise from T cells (T lymphocytes) that are taken from the patient, then expanded ex vivo and then reinfused into the patient.
- the invention is based on the problem of designing and developing a small-volume liquid container in such a way that the addition of a liquid medium into a closed system is simplified for the end user.
- the above problem is solved by the features of the characterizing part of claim 1 in the case of a small-volume liquid container for the delivery of a liquid, in particular biological, medium according to the preamble of claim 1.
- the proposed liquid container has, in addition to two dimensionally stable container parts that allow the medium to be pressed out of the receiving volume through a relative movement to one another, an element that delimits the receiving volume for the medium and changes its shape through the relative movement of the container parts.
- This element referred to below as the shape-changeable limiting means, preferably forms a flexible vessel which can be easily filled in a sterile manner by the manufacturer with the exact amount of liquid medium required and which can then be easily emptied by the user through a relative movement of the two dimensionally stable container parts .
- the filling made by the manufacturer possible with the proposed solution initially has the advantage that very large numbers of items can be produced automatically under industrial conditions, which considerably reduces the risk of contamination compared to manual filling.
- a particularly precise filling of the liquid container with the precisely prescribed amount of liquid medium can be carried out in this way, with an always constant amount even with large quantities can be guaranteed.
- the cost of filling is correspondingly low compared to manual filling.
- the addition of the liquid medium from the liquid container into the closed system is also significantly optimized. As already mentioned, this ensures, on the one hand, that the respective liquid container always contains the precisely prescribed amount of liquid medium. On the other hand, it is guaranteed that when several liquid containers are used in the course of a biotechnological process, they all contain exactly the same fill quantity. Finally, a particularly high degree of sterility is guaranteed, since the receiving volume has been filled under sterile conditions and in the particularly preferred case that the dimensionally stable container parts are also provided by the manufacturer, they are also available to the end user in sterile conditions.
- the proposed liquid container can be made available to the end user in sterile packaging as a unit, which is preferably already exactly filled with the liquid medium. Since the unit is preferably already filled and sterile available to the user, a sterile connection only needs to be provided to the user when transferring the liquid medium from the liquid into the closed system.
- the shape-changeable delimitation means provided according to the proposal also makes the subsequent disposal less expensive. Certain biological media can in principle pose a risk to humans and the environment. In order to avoid this, in the case of the proposed liquid container, the delimitation means can be easily separated from the dimensionally stable container parts and disposed of separately, for example incinerated. The dimensionally stable container parts that have not come into contact with the biological medium can then be reused after sterilization or another inactivation technique.
- the liquid container has a shape-changeable limiting means which at least partially delimits the receiving volume and which is connected to the dimensionally stable container parts in such a way that a relative movement of the dimensionally stable container parts to one another with a change in shape of the delimiting means causes a change in volume of the receiving volume goes hand in hand.
- a change in shape means that at least two sections of the delimiting means, which each limit the receiving volume, change their position relative to one another, in particular are moved towards one another, due to the relative movement of the two dimensionally stable container parts.
- the two portions of the limiting means changing their position can be folded towards each other, or, if they are already arranged in the form of a folding device, such as a bellows, the space filled with the medium can be used in the context of the change in shape be reduced between the sections of the limiting means.
- the change in shape is therefore associated in particular with no or at least no significant elastic deformation of the material of the delimiting means.
- the limiting means limit the receiving volume at least essentially alone.
- “Essentially” here means that the delimitation means can be provided with an opening, in particular an outlet opening, which can be closed by an additional element, for example an extension such as a hose or a tube, until the liquid medium is dispensed so that in this case the additional element also forms part of the limitation of the receiving volume.
- the delimitation means completely delimits the receiving volume and, at least initially, does not have an opening, but rather an outlet opening is only formed in the course of the delivery of the liquid medium, for example at a predetermined breaking point.
- Claim 3 defines particularly preferred configurations of the limiting means, in particular in the event that this limits the receiving volume at least essentially by itself.
- claims 4 and 5 particularly preferred ways of arranging the limiting means relative to the dimensionally stable container parts are given.
- Claims 6 to 8 relate to particularly preferred ways of interacting and designing the dimensionally stable container parts.
- the liquid container is defined in claims 9 and 10 which enable the liquid medium to be dispensed and, if necessary, filled.
- the limiting means and / or a dimensionally stable container part can form the outlet connection and, if appropriate, also a filling connection.
- the receiving volume of the proposed liquid container is already filled with egg nem liquid medium, in particular by the manufacturer.
- Claim 12 defines a projection on one or both dimensionally stable Be container parts, which protrudes in the end position of the dimensionally stable container parts into the space that is laterally limited by the material of the delimitation means.
- This space also called dead space, inevitably remains in the end position because the material of the delimitation means, for example the folded layers of a bellows, occupies a certain volume in the end position and cannot be squeezed completely flat. So that as little liquid medium as possible remains in this remaining space, the protrusion penetrates into the remaining space while the volume change of the receiving volume causes the relative movement of the dimensionally stable container parts to one another and displaces the liquid medium located therein at least for the most part, essentially completely.
- a packaging arrangement with a packaging and a liquid container according to the proposal which is sterile packed therein is claimed as such.
- the proposed packaging arrangement has a proposed liquid container, may reference is made to all relevant statements on the first-mentioned teaching.
- a liquid medium can be fed into a closed system, in particular a bioreactor, particularly easily without any significant risk of contamination, in that the liquid container is already sterile for the end user State is provided. It is particularly preferred that the proposed liquid container is already filled in this state, as already explained.
- one or all of the components of the proposed liquid container are preferably designed as single-use components, the components preferably being made of a plastic material.
- FIG. 1 shows a proposed small volume liquid container in a perspective view a) during use, b) before use and c) after use
- FIG. 2 shows a sterile packed, proposed liquid container according to FIG. 1 in a side view
- FIG. 3 shows the proposed liquid container according to FIG. 1 in a) perspective view and b) exploded view, with c) showing a variant of b),
- FIG. 4 shows the proposed liquid container according to FIG. 1 in one
- FIG. 5 shows a proposed liquid container according to a second embodiment a) in a perspective view before use, b) in a side view before use and b) in a side view after use, and
- Fig. 6 shows a proposed liquid container according to a third embodiment a) in a perspective view before use, b) in a side view before use and b) in a side view after use.
- the proposed low-volume liquid container 1 shown in FIGS. 1 to 6 in various exemplary embodiments is used to dispense a liquid, in this case biological, medium pre-filled by the manufacturer into a bioprocess engineering system, in particular a bioreactor, which forms a closed system or in a closed system is integrated.
- the bioreactor not shown here for reasons of clarity, is designed, for example, as a laboratory bioreactor, i.e. as a bioreactor which, in contrast to a production bioreactor, has a relatively small working volume (maximum available filling volume) of a maximum of 10 liters.
- Such a bioreactor is used to carry out a biotechnological process which, here and preferably, is used to produce a drug for novel therapies (ATMP).
- ATMP drug for novel therapies
- the biotechnological process can also be a cell expansion process for T cells.
- a biological reaction medium is provided in the bioreactor, which in particular has tissue cells or microbial cells and a nutrient medium.
- tissue cells or microbial cells and a nutrient medium.
- the proposed liquid container 1 is seen especially for this purpose.
- This provides a receiving volume 2 for the liquid medium.
- the liquid medium has already been filled into the receiving volume 2 by the manufacturer in the prescribed amount under sterile conditions, the otherwise sterile liquid container 1 then being packaged in a sterile manner.
- the proposed liquid container 1 is then made available to the end user.
- FIG. 2 shows an example of a packaging arrangement 3 with a packaging 4 and a liquid container 1 according to the proposal packed in a sterile manner therein.
- the liquid container 1 is already completely preassembled and here and preferably as a single-use unit 5 designed, so as a unit 5, in which all components are single-use components (disposable components). If the single-use unit 5 is exchanged accordingly, the risk of cross-contamination is considerably reduced.
- the proposed liquid container 1 also has, as particularly FIGS. 3 to 6 illustrate, two dimensionally stable container parts 6, 7 movable relative to one another between an initial position and an end position and an outlet connection 8 for discharging the liquid medium.
- FIGS. 4a), 5b) and 6b) show the position in which the receiving volume 2 has its maximum size or in which the receiving volume 2 is filled with the amount of liquid medium prescribed for dispensing into the bioreatechni cal system .
- the end position as i.a. Figures 4b), 5c) and 6c) show, correspondingly meant the position in which the receiving volume 2 has its minimum size or in which the prescribed amount of liquid medium has been diverted from the receiving volume 2.
- the proposed liquid container 1 has a shape-changeable limiting means 9 which at least partially delimits the receiving volume 2 and is connected to the dimensionally stable container parts 6, 7 in such a way that a change in volume of the receiving volume mens 2 causing relative movement of the dimensionally stable container parts 6, 7 zuei nander with a change in shape of the limiting means 9 is associated.
- the shape of the limiting means 9 is changed, as is shown by a synopsis of Figures 4a) and b), a synopsis of Figures 5b) and c), or a synopsis of Figures 6b) and c), in that the container part 6 relative to the container part 7, here by manual force, is displaced, whereby the container part 6 is moved here and preferably, in the direction of the container part 7.
- the accompanying change in shape of the limiting means 9 has a direct change, namely a reduction in the size of the receiving volume 2 result. As a result, the liquid medium is discharged from the receiving volume 2 and thus from the proposed liquid container 1 via the outlet connection 8.
- a sterile connection can be established, for example, via a sterile connector, which couples the liquid container 1 or a hose on the container side, described in more detail below, to the bioprocess engineering system or a hose on the system side in a sterile fluidic manner.
- a hose on the container side which is initially sealed, can be fluidically coupled in a sterile welding process to a corresponding and likewise initially sealed hose on the system or reactor side.
- the limiting means 9 limits the intake volume 2 at least essentially alone. Only one extension 10, which is coupled to the liquid container 1 and / or the limiting means 9 via the outlet connection 8 and which is described in more detail below, is also part of the limitation of the receiving volume 2 here.
- the receiving volume 2 extends here and preferably within the limit
- the receiving volume 2 is at least substantially completely delimited by the delimiting means 9 together with one or both container parts 6, 7 .
- the delimitation means 9 completely or at least essentially completely forms the receiving volume 2, since in this way the delimitation means 9 can be filled and disposed of independently of the dimensionally stable container parts 6, 7.
- the container parts 6, 7 can be brought together in this way after the delimitation means 9 has been filled, the delimitation means 9 preferably being arranged between the container parts 6, 7's. After the liquid medium has been dispensed, the delimitation means 9 can optionally also be separated from the container parts 6, 7, the container parts 6, 7 being reusable after the delimitation means 9 has been disposed of.
- the limiting means 9 is a bellows 11, here and preferably a bellows.
- the bellows 11 or bellows is compressed here in the direction of the outlet connection 8, in particular according to the accordion principle, whereby the liquid medium exits via the outlet connection 8.
- a projection 18 can be provided on one, here the upper, dimensionally stable container part 6, which protrudes in the end position of the container parts 6, 7 into the space covered by the material of the limiting means 9, here by the folds of the bellows, is laterally limited. “Laterally” here means the direction transverse to the direction in which the container parts are moved relative to one another.
- the projection 18 is in the starting position the shape-changeable limiting means 9 and / or the receiving volume 2 facing projection 18, which is connected in particular with the container part 6 or formed integrally therewith.
- a bellows 11 is provided as the limiting means 9, which bellows is compressed over the container parts 6, 7 in order to discharge the liquid medium.
- the bellows 11 is, however, not compressed towards the outlet port 8, but rather in a direction around the outlet port 8.
- the bellows 11 is designed here together with the stable container parts 6, 7 according to the principle of a bellows, that is, the bellows 11 is thicker in the initial position on the side facing away from the outlet connection 8 than on the side facing the outlet connection 8 and in the end position essentially the same thickness on both sides.
- the bellows 11 is thicker in the initial position on the side facing away from the outlet connection 8 than on the side facing the outlet connection 8 and in the end position essentially the same thickness on both sides.
- a projection 18 on at least one, here both the upper and the lower, dimensionally stable container part 6, 7 can be seen in the end position of the container parts 6, 7 protrudes into the space which is laterally limited by the material of the limiting means 9, here by the folds of the Bla senbalgs.
- “laterally” means the direction transverse to the direction in which the container parts are moved relative to one another.
- said space is only on one side of the material of the limita- tion means 9, here by the folds of the bladder bellows, laterally limited.
- the projection 18 is also in each case a projection 18 facing the shape-changeable limiting means 9 and / or the receiving volume 2 in the starting position, which is connected in particular to the respective container part 6, 7 or formed in one piece with it.
- the two projections 18 penetrate the remaining space (dead space) and displace the liquid medium located therein at least for the most part, essentially completely.
- the limiting means 9 is a tube 12, which is squeezed out by the movement of the container parts 6, 7 relative to each other in order to discharge the liquid medium.
- the said relative movement between the container parts 6, 7 does not compress the bellows 11 towards the outlet connection 8, but rather in a direction around the outlet connection 8.
- a projection can be provided on at least one dimensionally stable container part 6, 7, which protrudes into the space in the end position of the container parts 6, 7 which is laterally limited by the material of the limiting means 9.
- the limiting means 9, so here and preferably the bellows 11 or the Tu be 12, is in each of the embodiments releasably, in particular positively, inserted in at least one of the dimensionally stable container parts 6, 7 and / or between the two dimensionally stable container parts 6, 7 .
- This facilitates the separate filling of the receiving volume 2 or limiting means 9 and the subsequent disposal of the sen.
- the dimensionally stable container parts 6, 7 can be moved linearly with respect to one another. These form here and preferably a cylinder-piston arrangement 13, the upper container part 6 in FIG. 4 forming a piston 13a and the lower container part 7 forming a cylinder 13b in which the piston 13a is linearly movable. In the exemplary embodiments in FIGS. 5 and 6, however, the dimensionally stable container parts 6, 7 can be pivoted relative to one another. In the embodiment in Fig. 5, at least one of or are preferably both dimensionally stable Benzol tert parts 6, 7 designed plate-shaped. “Plate-shaped” means that they have essentially the same thickness over their entire extent and extend essentially along a plane.
- At least one of the dimensionally stable container parts 6, 7 is "Cup-shaped" here means that the respective container part 6, 7 delimits a receiving space in which the limiting means 9 can then be inserted, in the case of FIG. 6 the tube 12.
- the proposed liquid container 1 As here in the exemplary embodiments according to FIGS. 5 and 6, preferably so that the side facing the delimitation means 9 and / or the receiving volume 2 at least one of the container parts 6, 7, preferably both container parts 6, 7, is essentially flat in order to form an optimal contact surface for contact with the limiting means 9.
- the one dimensionally stable container part 6 on the other dimensionally stable container part 7 in the direction of the initial position is held.
- Le diglich is an example of a latching for this purpose, which is shown here only for the embodiment of FIG. 1, but can also be provided in the other embodiments.
- one of the container parts, here the lower container part 7, one or more latching lugs 14a and the other container part, here the upper container part 6, has a counterpart 14b that engages with it. If the dimensionally stable Benzol tert parts 6, 7 are moved from the initial position (Fig. 4a) to the end position (Fig. 4b), the counterpart 14b is moved past the respective locking lug 14a, which then forms a locking connection 14 in the end position.
- a latching connection 14 has the advantage that after the liquid medium has been dispensed, no medium can be sucked back into the receiving volume 2 due to a possible elastic recovery, in particular of the limiting means 9.
- a securing device 15, here an axial locking device 15, is shown, which prevents the container parts 6, 7 from being able to detach from one another in the initial position.
- the locking lugs 14a which interact positively with a further counterpart 15a, also serve here.
- the outlet connection 8 is formed on the limiting means 9, here the bellows 11.
- a filling connection 16 is also provided on the delimitation means 9 or bellows 11, in particular for filling the receiving volume 2 with the liquid medium by the manufacturer.
- the outlet connection 8 is formed on the limiting means 9.
- no additional filler connection is provided here.
- an outlet connection 8 can also be provided on one of the dimensionally stable container parts 6, 7.
- a hose 17a, 17b or tube is coupled here and preferably to the respective outlet connection 8 and, in the first embodiment, also to the filling connection 16, which forms the extension 10 already mentioned above.
- the liquid medium can then be discharged from the receiving volume 2 or introduced into it by the manufacturer via the hose 17a, 17b or the tube.
- the end of the hose 17a, 17b or tube pointing away from the liquid container 1 is here and preferably sealed by the manufacturer, in particular welded. To dispense the liquid medium, this seal is then removed beforehand, for example as part of the previously mentioned sterile welding process for the fluid connection of the respective hose 17a, 17b to a wider hose (not shown here), preferably on the system or reactor side.
- the hose 17a, 17b is already connected by the manufacturer to a coupling device of a sterile connector, which can then be technically coupled in a sterile fluid manner with a corresponding coupling device connected to a system-side or reactor-side hose.
- the receiving volume 2 is here and preferably so large that in the starting position the amount of liquid medium in the receiving volume 2, here and preferably the maximum filling amount, is up to 50 ml, preferably up to 40 ml, more preferably up to 30 ml .
- the packaging arrangement 3 which is shown by way of example in FIG. 2, is claimed with the Ver pack 4 and the proposed liquid container 1 as such, packaged in a sterile manner therein. As I said, it is preferred here if the packaging arrangement 3 contains the liquid container 1 in the already filled state. Reference may be made in this regard to all statements relating to the proposed liquid container 1.
- both the container parts 6, 7 and the limiting means 9, in particular the bellows 11, as well as the extension or extensions 10 in the form of the respective hose 17a, 17b or tube are packaged in the packaging 4.
- the proposed packaging arrangement 3, packaged sterile in the packaging 4 has exclusively the, preferably pre-filled, delimiting means 9, optionally with the extension or extensions 10 or the respective tube 17a, 17b or Tube.
- the dimensionally stable Be container parts 6, 7 can in this case be sterile packed in a separate packaging or provided by the end user.
- the liquid container 1 After the liquid container 1 has been unpacked from the packaging 4, it is connected to the respective bioprocessing system here via one of the extensions 10 or via the hose 17a or the tube.
- At least the limiting means 9, preferably also at least one of the dimensionally stable container parts 6, 7, in particular both dimensionally stable container parts 6, 7, and / or the hose or tubes 17a, 17b or small tubes are each egg- ne single-use component.
- the respective component, ie the limiter 9, the respective dimensionally stable container part 6, 7 and / or the respective hose 17a, 17b or the respective tube is at least partially, preferably at least predominantly, made of a plastic material.
- the limiting means 9 is preferably formed from a plastic film. A silicone material and / or a polymer material are particularly suitable as plastics for the individual components.
- PE polyethylene
- PP polypropylene
- PTFE polytetrafluoroethylene
- PBT polybutylene terephthalate
- PSU polysulfone
- PESU polyethersulfone
- PC polycarbonate
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Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021559938A JP2022528550A (ja) | 2019-04-10 | 2020-04-09 | 少量液体容器 |
KR1020217036583A KR20210151164A (ko) | 2019-04-10 | 2020-04-09 | 소용량 액체 용기 |
EP20720755.6A EP3953446A1 (de) | 2019-04-10 | 2020-04-09 | Mindermengen-flüssigkeitsbehälter |
US17/600,938 US20220195362A1 (en) | 2019-04-10 | 2020-04-09 | Shortfall quantity liquid container |
CA3135467A CA3135467A1 (en) | 2019-04-10 | 2020-04-09 | Small-volume liquid container |
SG11202111194SA SG11202111194SA (en) | 2019-04-10 | 2020-04-09 | Small-volume liquid container |
CN202080027343.0A CN113631697A (zh) | 2019-04-10 | 2020-04-09 | 减量-液体容器 |
IL287068A IL287068A (en) | 2019-04-10 | 2021-10-07 | Small-volume liquid container |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE102019109493.3A DE102019109493A1 (de) | 2019-04-10 | 2019-04-10 | Mindermengen-Flüssigkeitsbehälter |
DE102019109493.3 | 2019-04-10 |
Publications (1)
Publication Number | Publication Date |
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WO2020208160A1 true WO2020208160A1 (de) | 2020-10-15 |
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ID=70391080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2020/060198 WO2020208160A1 (de) | 2019-04-10 | 2020-04-09 | Mindermengen-flüssigkeitsbehälter |
Country Status (10)
Country | Link |
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US (1) | US20220195362A1 (de) |
EP (1) | EP3953446A1 (de) |
JP (1) | JP2022528550A (de) |
KR (1) | KR20210151164A (de) |
CN (1) | CN113631697A (de) |
CA (1) | CA3135467A1 (de) |
DE (1) | DE102019109493A1 (de) |
IL (1) | IL287068A (de) |
SG (1) | SG11202111194SA (de) |
WO (1) | WO2020208160A1 (de) |
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US20080045857A1 (en) * | 2002-05-31 | 2008-02-21 | Miller Larry J | Bone Marrow Aspiration Devices and Related Methods |
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- 2019-04-10 DE DE102019109493.3A patent/DE102019109493A1/de active Pending
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2020
- 2020-04-09 CA CA3135467A patent/CA3135467A1/en active Pending
- 2020-04-09 SG SG11202111194SA patent/SG11202111194SA/en unknown
- 2020-04-09 US US17/600,938 patent/US20220195362A1/en active Pending
- 2020-04-09 JP JP2021559938A patent/JP2022528550A/ja active Pending
- 2020-04-09 WO PCT/EP2020/060198 patent/WO2020208160A1/de unknown
- 2020-04-09 CN CN202080027343.0A patent/CN113631697A/zh active Pending
- 2020-04-09 KR KR1020217036583A patent/KR20210151164A/ko active Search and Examination
- 2020-04-09 EP EP20720755.6A patent/EP3953446A1/de active Pending
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2021
- 2021-10-07 IL IL287068A patent/IL287068A/en unknown
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US4411656A (en) * | 1982-01-29 | 1983-10-25 | Urologic & Enteric Research Associates | Compressible syringe |
EP0094101A2 (de) * | 1982-05-12 | 1983-11-16 | Fresenius AG | Steriler Behälter für medizinische Zwecke |
EP0170784A1 (de) * | 1984-06-05 | 1986-02-12 | Intermedicat GmbH | Infusionsspritzenpumpe |
US20080045857A1 (en) * | 2002-05-31 | 2008-02-21 | Miller Larry J | Bone Marrow Aspiration Devices and Related Methods |
EP1679365A1 (de) * | 2003-10-20 | 2006-07-12 | JMS Co., Ltd. | Zellhandhabungsvorrichtung, zusammensetzung zur regeneration von menschlichem gewebe sowie verfahren zur regeneration von menschlichem gewebe |
Also Published As
Publication number | Publication date |
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KR20210151164A (ko) | 2021-12-13 |
SG11202111194SA (en) | 2021-11-29 |
IL287068A (en) | 2021-12-01 |
EP3953446A1 (de) | 2022-02-16 |
JP2022528550A (ja) | 2022-06-14 |
US20220195362A1 (en) | 2022-06-23 |
CN113631697A (zh) | 2021-11-09 |
DE102019109493A1 (de) | 2020-10-15 |
CA3135467A1 (en) | 2020-10-15 |
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