WO2020054996A1 - Formulation solide pour bain de bouche moussant et procédé de préparation de celle-ci - Google Patents

Formulation solide pour bain de bouche moussant et procédé de préparation de celle-ci Download PDF

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Publication number
WO2020054996A1
WO2020054996A1 PCT/KR2019/010641 KR2019010641W WO2020054996A1 WO 2020054996 A1 WO2020054996 A1 WO 2020054996A1 KR 2019010641 W KR2019010641 W KR 2019010641W WO 2020054996 A1 WO2020054996 A1 WO 2020054996A1
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Prior art keywords
extract
agent
less
mixture
foamable
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PCT/KR2019/010641
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English (en)
Korean (ko)
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이은상
백현숙
이주환
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(주)주환바이오.셀
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Priority to JP2019559093A priority Critical patent/JP2021502325A/ja
Priority to CN201980002071.6A priority patent/CN111315356A/zh
Publication of WO2020054996A1 publication Critical patent/WO2020054996A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures

Definitions

  • the present invention relates to a foamable solid agent for mouthwash, and more particularly, to a foamable solid agent for mouthwash comprising a mixture of grape extract, green tea extract, golden extract and bellflower extract as an active ingredient.
  • Toothpaste also known as a dentifrice, is a detergent used in combination with a toothbrush to clean the tooth surface in the mouth when brushing, and is a quasi-drug.
  • the primary purpose of toothpaste use is to effectively remove bacterial plaque attached to the tooth surface, and has been expanded for additional purposes such as dental caries, periodontal disease prevention, whitening effect, slowing perception, and bad breath suppression.
  • the main components of toothpaste include abrasives, water, moisturizers, detergents, binders, flavoring agents, sweeteners, prophylactic treatments, pigments and preservatives.
  • abrasives include abrasives, water, moisturizers, detergents, binders, flavoring agents, sweeteners, prophylactic treatments, pigments and preservatives.
  • active ingredients such as drugs or chemicals that suppress dental caries and prevent periodontal disease are selectively added.
  • toothpaste is composed of a paste, powder, gel, mucus, and liquid.
  • the paste phase is the most widely distributed, but it is highly likely to cause damage to the tooth enamel layer by the abrasive component, and it is inconvenient to squeeze when used, and the remaining amount in a container that is discarded There is a problem that the toothpaste remains.
  • the powdery phase has the disadvantage that it is inconvenient to use because the particles are sprayed or scattered during use, and the gel phase has low spreadability due to high viscosity and is not easily dispersed in the oral cavity.
  • the liquid phase flows easily due to its low viscosity, and it is difficult to expect a sufficient cleaning effect due to lack of cleaning ingredients.
  • Korean Patent Publication No. 10-2012-0079537 discloses a sheet-type toothpaste
  • Korean Patent Publication No. 10-2015-0051296 discloses a foam-type toothpaste disclosed in Korean Patent Publication No. 10-2004-0008953.
  • a pill form toothpaste There is disclosed a pill form toothpaste.
  • the developed toothpaste can stimulate consumer curiosity beyond the formulation of a general detergent, but there is a problem in that the conventional toothpaste simply deforms the formulation or has a poor cleaning effect, and still needs brushing. . Therefore, there is a need to develop a detergent that is convenient to use and has improved efficacy.
  • resveratrol which is known as a natural extract that is harmless and safe to the human body, is a kind of polyphenols contained in plants of peanuts and grape extracts, and emits for self-defense when plants are exposed to external stresses such as ultraviolet rays and pathogens. It is one of the phytoalexin compounds (biological defense materials).
  • Catechin also known as green tea extract, belongs to flavan-3-ols of the flavonoid group and is a type of polyphenol. It is known to have anti-carcinogenic, arteriosclerotic, antiviral, anti-obesity, anti-diabetic, antibacterial, detoxifying, and anti-inflammatory effects, and particularly has dental caries prevention and bad breath prevention effects.
  • Baikalin (baicalin) is one of the flavonoids contained in Lamiaceae and roots, and has efficacy such as anti-inflammatory and antioxidant, and is used in various forms in vivo.
  • a foamable solid agent for mouthwash was developed that excludes harmful synthetic chemicals and contains only natural products as an active ingredient.
  • KR 10-1448283 B1, KR 10-2005-0086796 A, and KR 10-1056573 B1 were used as prior art documents.
  • the present invention includes a mixture of grape extract, green tea extract, golden extract and bellflower extract as an active ingredient, does not require tooth brushing, removes bad breath, gingivitis and effervescent foam for oral cleaning with anti-microbial efficacy
  • the purpose is to provide siblings.
  • a foamable solid agent for mouthwash comprising a mixture of grape extract, green tea extract, golden extract and bellflower extract as an active ingredient.
  • the grape extract contains resveratrol as an active ingredient
  • the green tea extract contains catechin as an active ingredient
  • the golden extract contains Baikalin as an active ingredient
  • the bellflower extract is characterized by a long path.
  • the foamable solid agent for mouthwash includes sodium hydrogen carbonate as a foaming agent, and is characterized by further comprising a surfactant, a pH adjusting agent, a formulation agent, an abrasive, a disintegrant, a lubricant, a sweetener, and a fragrance.
  • the grape extract, the green tea extract, the golden extract and the bellflower extract is made of 1: 7: 2: 4 by weight
  • the blowing agent is characterized in that it comprises 20 parts by weight based on 100 parts by weight of the total composition.
  • the formulation agent is crystalline cellulose
  • the abrasive is calcium carbonate
  • the disintegrant is lactose and starch
  • the lubricant is magnesium stearate
  • the pH adjusting agent is DL-apple acid
  • the surfactant is L-Lysin and olive oil It is characterized by.
  • the foamable solid agent for oral cleaning is foamed within 30 seconds after oral injection, and is characterized by having dentin remineralization and dentinal tubule closure.
  • a step of mixing a mixture consisting of grape extract, green tea extract, golden extract and bellflower extract, surfactant, pH adjusting agent, formulation agent, abrasive, disintegrant, lubricant, sweetener and flavoring agent; Two steps of aging the mixture; 3 steps of tableting the aged mixture; Four steps of aging the tableted mixture; 5 steps of coating the aged mixture; 6 steps for drying the coated mixture; provides a method for preparing a foamable solid for mouthwash comprising a.
  • the mixture of the grape extract, green tea extract, golden extract, and bellflower extract in step 1 and a surfactant, a pH adjusting agent, a formulation agent, an abrasive, a disintegrant, a lubricant, a sweetener and a fragrance, at a temperature of 22 ° C. or less and humidity It is preferable to mix for 15 minutes at a speed of 30 rpm or less under conditions of 40% or less, and the mixture is aged for 8 hours in a sealed state at a temperature of 25 ° C or less and a humidity of 60% or less.
  • the aged mixture is preferably compressed to a pressure of 2,000 kg / cm 2 and a speed of 30 rpm under conditions of a temperature of 20 ° C. or less and a humidity of 40% or less, and the compressed mixture is temperature 25 ° C. or less and humidity 60
  • the aged mixture was first coated at 1.5 rpm for 90 minutes and 2.5 rpm for 60 minutes under heat exchanger pressure of 0.2 Mpsi, air compressor pressure of 4 to 6 bar, and gun injection pressure of 5 bar, followed by 3.5 rpm for 60 minutes and 4.5. It is preferable to undergo a step of secondary coating for 30 minutes at rpm. It is preferable to dry the coated mixture for 8 hours in a sealed state at a temperature of 25 ° C. or less and a humidity of 60% or less.
  • the effervescent solid agent for oral cleaning according to the present invention is a new solid agent type, which is convenient to carry, and can be conveniently and easily administered to the mouth without water or a toothbrush when going out at home and regardless of the place.
  • the abundant foam quickly penetrates to clean every corner, and the tooth protection and cleaning effect is faster than that of the prior art. Accordingly, it is effective for people with weak teeth and weak teeth or gums, and no residue remains after brushing.
  • it has excellent dentin remineralization and ivory tubule closing effect, has anti-inflammatory and antibacterial functions in the oral cavity, and prevents tooth decay, bad breath removal, and scaling.
  • 1 is a graph of changes in the gingival gingival index attached to the nipple margins.
  • 2 is a graph of Talbott's gingivitis index change.
  • Figure 3 is a graph of the change in the surface area management ability index.
  • 5 is a halitosis change graph measured by a halitometer.
  • 6 is a graph of sensory evaluation changes.
  • 9 is a graph for testing the effect of removing bad breath according to the concentration of hydrogen sulfide.
  • 10 is a graph for testing the effect of removing bad breath according to the concentration of methyl mercaptan.
  • foamable solid agent for oral cleaning of the present invention will be described in more detail.
  • the effervescent solid for oral cleaning of the present invention includes a mixture of grape extract, green tea extract, golden extract and bellflower extract as an active ingredient, the grape extract is resveratrol, the green tea extract is catechin, and the golden extract is Baikal It contains lean as an active ingredient, the bellflower extract is preferably long.
  • the resveratrol is a polyphenol-based material found in more than 70 species of plants such as peanuts, grapes, pine trees, and red wine, and exists in two forms, cis-resveratrol and trans-resveratrol, as shown in the structure shown below.
  • resveratrol was found to act as a phytoalexin, an antibiotic produced by plants to fight bacteria and fungi, and the anticancer effect of lasveratrol was reported in 1997.
  • yeast activates the long-lived gene SIRT1.
  • resveratrol has been shown to be effective in treating asthma, chronic obstructive pulmonary disease (COPD) and arthritis due to its wide range of anti-inflammatory effects. According to it, resveratrol has several tens and hundreds of times more antioxidants than vitamins and minerals, and it can be used to help prevent and treat gum disease by Dr. Patiachandard of the University of Quebec-Siraval, Canada. As described above, resveratrol is effective in preventing and treating oral diseases as physiological activity effects such as anti-inflammatory, antioxidant, and gum disease prevention are reported.
  • the catechin is a type of polyphenol contained in green tea, and main catechins include EGCG (epigallocatechin gallate), EGC (epigallocatechin), ECG (epicatechin gallate), and EC (epicatechin).
  • EGCG which accounts for 40% of total polyphenols, is known to have the strongest physiological activity.
  • Catechins have been reported to have excellent bactericidal effects against oral bacteria (The Korean Journal of Microbiology, Vol. 40, No. 4, 2004: 364-366), and antioxidant and antibacterial activity effects of catechins extracted from tea have been published ( Horticulture Environment and Biotechnology, Vol. 10, 2007: 114-114).
  • the baicalin is a type of flavonoids contained in the roots of Lamiaceae and Golden (Scutellaria baicalensis Georgi), and the reported major physiological activity is antibacterial and anti-inflammatory activity, and in addition, it has effects on antiviral, antioxidant, and anticancer effects. It was reported to indicate. As an example, it has been reported that the golden extract has antibacterial activity and anti-adhesion effect against Streptococcus mutans, the causative agent of dental caries (Journal of Dental Hygiene Science, Vol. 8, No. 4, 2008: 367-373), and accordingly Lean's bioactive effect can be used for periodontal disease prevention and oral care.
  • the Gilty (Platycodonis Radix) is an excellent alkaline food with various active ingredients such as proteins, sugars, lipids, minerals, vitamins and saponins, including abundant fiber, iron, and calcium.
  • Gilkyung contains triterpenoid saponin and phytosterol components.
  • Triterpenoid saponin has anti-inflammatory effect. In oriental medicine, it acts on the lungs to treat many symptoms of seawater and phlegm and uncomfortable breathing. It is used for sore throat, cough due to cold, phlegm, nasal congestion, asthma, bronchitis, pleurisy, headache, chills, tonsillitis.
  • pharmacological action was reported as expectorant action, hypoglycemic action, cholesterol lowering action, and improved bacteriostatic action.
  • the grape extract, the green tea extract, the golden extract and the bellflower extract is preferably made of 1: 7: 2: 4 by weight.
  • the foamable solid agent for mouthwash preferably contains sodium hydrogen carbonate as the foaming agent for foaming, and the foaming agent preferably contains 20 parts by weight based on 100 parts by weight of the total composition.
  • the sodium hydrogen carbonate has a soft abrasive power, has an excellent inhibitory effect on bacteria in the oral cavity, and has a tooth decay prevention effect by neutralizing the organic acid produced by plaque.
  • the solid agent further includes a surfactant, a pH adjusting agent, a formulation agent, an abrasive, a disintegrant, a lubricant, a sweetener, and a fragrance.
  • the surfactant is preferably L-Lysin and olive oil, and the pH adjusting agent is preferably DL-apple acid.
  • the formulation agent contains crystalline cellulose as a role for bonding foaming agents, abrasives, and the like, and is added for production into a solid.
  • the abrasive preferably contains calcium carbonate, and plays an important role in cleaning such as removal of plaque and food, and should not damage the enamel of teeth, and compatibility with other ingredients should be secured.
  • the disintegrant comprises lactose and starch.
  • the lubricant is added to prevent foreign substances from being caught in the punch of the tableting machine during the tableting process, and preferably contains magnesium stearate.
  • the sweetener is added to overcome the basic taste of the solid agent, and may be L-menthol, D-sorbitol, xylitol, or enzymatically treated stevia.
  • the fragrance is added to reinforce, modify or suppress the fragrance.
  • the solid agent foams within 30 seconds after oral administration, and has dentin remineralization and dentinal tubule closure.
  • the present invention in another aspect, a mixture of a grape extract, green tea extract, golden extract and bellflower extract, surfactant, pH adjusting agent, formulation agent, abrasive, disintegrating agent, lubricant, sweetener and fragrance at a temperature of 22 ° C. or less and humidity Mixing for 15 minutes at a speed of 30 rpm or less at a condition of 40% or less; Aging the mixture in a sealed state at a temperature of 25 ° C. or less and a humidity of 60% or less for 8 hours; Compressing the aged mixture at a temperature of 20 ° C.
  • the temperature is 25 ° C or less and humidity It was aged for 8 hours in a sealed state at a condition of 60% or less.
  • the aged raw material was compressed at a pressure of 2,000 kg / cm 2 and a speed of 30 rpm using a tablet press under conditions of a temperature of 20 ° C. or less and a humidity of 40% or less, and then sealed in a sealed condition at a temperature of 25 ° C. or less and a humidity of 60% or less Aged for an hour.
  • the aged raw material was first coated with a heat exchanger pressure of 0.2 Mpsi, a main air compressor pressure of 4 to 6 bar, and a gun injection pressure of 5 bar using a coating machine.
  • the exhaust temperature was 35 to 38 ° C, and 1.5 It was performed for 90 minutes at rpm and 60 minutes at 2.5 rpm.
  • the second coating was performed under the same conditions as the first coating.
  • the exhaust temperature was 45 to 48 ° C, and it was performed at 3.5 rpm for 60 minutes and 4.5 rpm for 30 minutes.
  • the mixture was dried for 8 hours in a sealed state at a temperature of 25 ° C or lower and a humidity of 60% or lower.
  • Comparative Example 2 (standard detergent) was prepared, which consisted only of the components of a conventional detergent using dental type silica as a main component.
  • Comparative Example 3 control detergent
  • test subjects 120 adult men and women aged 20 to 50 years with mild-to-moderate gingivitis symptoms were selected as test subjects, and the test subjects were tested in groups of 30 each after a one-week run-in period. , Comparative group, negative control group, divided into four groups of the positive control group, the test was conducted for 4 weeks, and test examples 1 to 4 were performed at intervals of 1 week, 2 weeks, and 4 weeks.
  • Example 1 and Comparative Example 1 tablets were placed in the mouth, masticated, and crushed using the tongue and lips to rub the gums, teeth, and tongue and spit them out by rubbing and gargle. .
  • an appropriate amount (10 cc) was kept in the mouth for about 1 minute, and was used as a spitting method.
  • Table 2 below shows the gender and age distribution of all subjects.
  • the gingival marginal gingival index was measured for the maxillary and mandibular anterior gingival teeth, which are shown in Table 3 and FIG. 1 below.
  • the PMA index at week 0 before the test was not significantly different between the 4 groups (p> 0.05) in the test group 11.27, the comparison group 11.30, the negative control group 11.33, and the positive control group 11.30, and after one week, the PMA index was the test group 11.03, comparison group 11.07. , Negative control group 11.67, positive control group 11.10, and after 2 weeks, the PMA index was examined in the test group 10.93, comparison group 10.80, negative control group 11.63, and positive control group 10.80.
  • the PMA index was examined as 10.20 in the test group, 11.07 in the comparison group, 11.90 in the negative control group, and 10.20 in the positive control group, and the test group and the positive control group were significantly lower in the PMA index than the negative control group (p ⁇ 0.05), it was confirmed that the PMA index of the test group and the positive control group decreased to a statistically significant level 4 weeks after the test (p ⁇ 0.05).
  • the embodiment of the present invention showed a similar degree of gingivitis relief effect when using a conventional oral brushing solution.
  • the gingivitis index is divided into mesial, centrifugal, and central gingivitis, respectively, according to the rating criteria of the gingivitis of Loe modified by Talbott, Mandel and Chilton. Was calculated as the arithmetic mean.
  • the gingivitis index of an individual was calculated by dividing the sum of the measured values of each part by the number of teeth to be examined. At this time, the total number of teeth to be tested was # 16, # 11, # 26, # 46, # 31, and # 36 teeth. Was made.
  • the gingivitis rating criteria for each site of Loe are as follows, and the results are shown in Table 4 and FIG. 2 below.
  • the pre-test Talbott's gingivitis index was 1.33 in the test group, 1.33 in the comparison group, 1.36 in the negative control group, and 1.35 in the positive control group. There was no significant difference between the 4 groups.Measurement after 1 week was 1.31 in the test group, 1.35 in the comparison group, and 1.37 in the negative control group. There was no significant difference between the 4 groups, which was investigated as the control group 1.31. Measurements after 2 weeks were examined as test group 1.24, control group 1.33, negative control group 1.41, and positive control group 1.22. Measurements after 4 weeks were examined as test group 1.19, control group 1.26, negative control group 1.44, and positive control group 1.12.
  • the gingivitis index of the test group and the positive control group was significantly lower than that of the test (p ⁇ 0.05).
  • the gingivitis index was higher in the negative control group after 4 weeks than in the test (p ⁇ 0.05).
  • the test group and the positive control group had significantly lower gingival index than the control and negative control groups ( p ⁇ 0.05)
  • the gingivitis index was significantly lower in the control group than in the negative control group (p ⁇ 0.05).
  • the gingivitis index of the positive control group was the lowest, but it was not significantly different from the test group, and it was confirmed that there was a significant difference between the control group and the negative control group.
  • Test example 2 Dental hygiene membrane evaluation
  • the degree of adhesion of the dental hygiene membrane was evaluated by the dental hygiene management ability index, and the teeth to be examined were # 16, # 11, # 26, # 46, # 31, and # 36 teeth.
  • the pre-test PHP index was test group 2.23, comparative group 2.16, negative control group 2.16, positive control group 2.21, and after one week, the PHP index was test group 2.18, comparison group 2.07, negative control group 2.21, positive The control group 2.06, the PHP index after 2 weeks was tested in the test group 2.07, the comparison group 2.15, the negative control group 2.21, the positive control group 2.09, and the 4 weeks later the PHP index was tested in the test group 2.04, the comparison group 2.09, the negative control group 2.35, and the positive control group 2.08. There was no significant difference between the 4 groups before, 1 and 2 weeks after the test (p> 0.05), and the PHP index was significantly lower in the test group after 4 weeks than the negative control (p ⁇ 0.05). . Through the above results, it was confirmed that the embodiment of the present invention has superior ability to inhibit the formation of dental bacterial membranes compared to the case where the mouth was not washed.
  • the degree of attachment of the dentifrice membrane was measured using Turesky-modified Quigley and Hein's dentifrice membrane rating criteria, and the teeth tested were # 15, # 13, # 26, # 44, # 32, and # 36 teeth.
  • Turesky's surface microbial index was tested before test group 2.58, comparison group 2.60, negative control group 2.55, positive control group 2.58, test group 2.53 after 1 week, comparison group 2.53, negative control group 2.56, Positive control group 2.51, 2 weeks later, test group 2.55, comparison group 2.47, negative control group 2.57, positive control group 2.49, and after 4 weeks, test group 2.44, control group 2.47, negative control group 2.67, and positive control group 2.45.
  • test group and the positive control group showed significantly lower dental plaque index than the negative control group ( p ⁇ 0.05).
  • Halitosis evaluation was conducted using a bad breath meter BB Checker (Plustech, Daejeon, Korea), and the measured values are shown in Table 7 and FIG. 5 below.
  • a bad breath evaluation was performed through a sensory test using a visual analogue scale, which is shown in Table 8 and FIG. 6 below.
  • Dentin refers to the layer under the enamel, consisting of 70% inorganic, 20% organic, and 10% moisture.
  • the sensitivity of the teeth increases because it is not protected from external stimuli, and as a result, all stimuli from the outside are transmitted to the nerves within the pulp and react more sensitively to the same stimuli. This can cause pain or tingling and tingling symptoms, such as hypersensitivity. Accordingly, remineralization of demineralized dentin is very important for root caries prevention and hypersensitivity treatment.
  • Test Example 6 Evaluation of artificial ivory tubule closing effect and whitening effect
  • Ivory tubules can be a path of bacterial penetration if there is dental caries or are exposed, and if physical, chemical stimulation and thermal stimulation are applied while the ivory tubules are exposed, the liquid in the ivory tubules moves in and out at a very high rate. And the pressure created by the movement of the ivory fluid affects the cells in the pulp. As a result, as the cells are stretched or compressed, the nerve contacting the cells senses this change and feels pain. Accordingly, the exposed ivory tubules can be closed to protect the teeth from gum disease and tooth decay, and to relieve hard caries and hypersensitivity.
  • the causes of bad breath are mainly volatile sulfur compounds, and the main components are hydrogen sulfide (H 2 S) and methyl mercaptan (CH 3 SH). Accordingly, the concentration of hydrogen sulfide and methyl mercaptan in the oral cavity was measured to evaluate the efficacy of removing bad breath.
  • Bad breath was measured 4 times in total after gas phase, immediately after washing, after 30 minutes of washing, and after 1 hour of washing. Comparative Example 1 was used as a control, and comparative analysis was conducted using a commercially available Gagreen as a comparative example. .
  • the concentration of methyl mercaptan is significantly lower when using Examples and Comparative Examples compared to the control group.
  • concentration of methyl mercaptan immediately after use of the example is 112 ppb, whereas the use of the comparative example shows 169 ppb immediately after use, which confirms that the deodorization rate is better when using the example, and maintains a low concentration even after a lapse of time. It can be confirmed through the bad breath removal effect.
  • the present invention is excellent in portability, easy to use, and has an industrial applicability because it can manufacture a foamable solid agent for mouthwash, which has excellent cleaning effect, bad breath removal, tooth decay prevention and other dental protection effects.

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Abstract

La présente invention concerne une formulation solide pour bain de bouche moussant et, plus spécifiquement, une formulation solide pour bain de bouche moussant, laquelle comprend, en tant que principe actif, un mélange d'un extrait de fruit de Vitis vinifera (raisin), d'un extrait de Camellia sinensis de type thé vert, d'un extrait de Scutellaria baicalensis et d'un extrait de Platycodon grandiflorus ; présente un excellent effet sur la reminéralisation de la dentine et sur la fermeture des tubules dentinaires ; fond en générant des bulles lorsqu'elle est placée en bouche, de telle sorte qu'il n'est pas besoin d'effectuer en plus un brossage des dents ; est excellente en termes d'efficacité de nettoyage ; et possède des effets anti-inflammatoires, antibactériens, de prévention des caries dentaires et de suppression de l'halitose, ainsi qu'un potentiel à être produite à l'échelle industrielle.
PCT/KR2019/010641 2018-09-11 2019-08-21 Formulation solide pour bain de bouche moussant et procédé de préparation de celle-ci WO2020054996A1 (fr)

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JP2019559093A JP2021502325A (ja) 2018-09-11 2019-08-21 口腔洗浄用発泡性固形剤及びその製造方法
CN201980002071.6A CN111315356A (zh) 2018-09-11 2019-08-21 口腔清洗用发泡性固形剂及其制备方法

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KR1020180108147A KR101985771B1 (ko) 2018-09-11 2018-09-11 구강세정용 발포성 고형제 및 이의 제조방법

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KR102389452B1 (ko) * 2020-02-07 2022-04-22 주식회사 비에스앤코 과립형 치약 조성물 및 이의 제조방법
KR102173528B1 (ko) * 2020-02-28 2020-11-03 주식회사 바른 섭취가 가능한 타블렛 또는 분말형 구강청결제 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000297022A (ja) * 1999-04-12 2000-10-24 Lion Corp 口腔用組成物
KR100805635B1 (ko) * 2006-07-06 2008-02-20 주식회사 엘지생활건강 안정성이 강화된 상전이 구취제거제
KR20120005150A (ko) * 2010-07-08 2012-01-16 애경산업(주) 치은염 및 치주질환을 예방하기 위한 구강용 조성물
KR20140093881A (ko) * 2013-01-18 2014-07-29 주식회사 한국코러스제약 구강세척용 발포 조성물
KR101985771B1 (ko) * 2018-09-11 2019-06-04 (주)주환바이오.셀 구강세정용 발포성 고형제 및 이의 제조방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR8807582A (pt) * 1987-06-25 1990-05-29 Dentab Inc Tablete e processo de fluoretacao e limpeza de dente e tablete de limpeza de dente isento de agua
WO1999027901A1 (fr) * 1997-12-03 1999-06-10 Kao Corporation Preparation solide pour l'hygiene buccale
JP2003095905A (ja) * 2001-09-27 2003-04-03 Nagase & Co Ltd 口腔用消臭剤
US20040101494A1 (en) 2002-11-26 2004-05-27 Scott Douglas Craig Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth
KR101056573B1 (ko) 2003-12-24 2011-08-11 주식회사 엘지생활건강 비수 발포성 치약 조성물
CN102524504A (zh) * 2012-03-13 2012-07-04 吴圣陶 一种护齿口香糖
KR101448283B1 (ko) 2012-03-22 2014-10-13 (주)한일제약 거품치약 조성물 및 그 제조방법
CN103436362A (zh) * 2013-08-16 2013-12-11 德利宝(广州)香料有限公司 一种含有天然葡萄提取物的香精及牙膏制备方法
CN103830115A (zh) * 2014-03-07 2014-06-04 中国人民解放军第四军医大学 表没食子儿茶素没食子酸脂在保护牙本质方面的应用
US20160303035A1 (en) * 2014-07-16 2016-10-20 Bio Nano Trinity. Co. Ltd Toothpaste Composition Containing Curcuma Longa L. and Method of Manufacturing Same
JP2016006102A (ja) * 2015-08-14 2016-01-14 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ 口腔ケア製品およびその使用方法および製造方法
CN105326708A (zh) * 2015-11-25 2016-02-17 王晓伟 三七美白牙膏
CN105534769A (zh) * 2015-12-22 2016-05-04 南昌理工学院 一种含黄芩提取物的抗菌牙膏
CN107847538B (zh) * 2016-05-18 2021-06-11 日本泽托克株式会社 口腔用组合物
CN108464963B (zh) * 2018-04-12 2020-06-16 弘美制药（中国）有限公司 一种用于口腔的组合物及其应用和制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000297022A (ja) * 1999-04-12 2000-10-24 Lion Corp 口腔用組成物
KR100805635B1 (ko) * 2006-07-06 2008-02-20 주식회사 엘지생활건강 안정성이 강화된 상전이 구취제거제
KR20120005150A (ko) * 2010-07-08 2012-01-16 애경산업(주) 치은염 및 치주질환을 예방하기 위한 구강용 조성물
KR20140093881A (ko) * 2013-01-18 2014-07-29 주식회사 한국코러스제약 구강세척용 발포 조성물
KR101985771B1 (ko) * 2018-09-11 2019-06-04 (주)주환바이오.셀 구강세정용 발포성 고형제 및 이의 제조방법

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