WO2020019929A1 - Compound chinese traditional medicine antibacterial composition and application thereof in toiletry products - Google Patents

Compound chinese traditional medicine antibacterial composition and application thereof in toiletry products Download PDF

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Publication number
WO2020019929A1
WO2020019929A1 PCT/CN2019/093400 CN2019093400W WO2020019929A1 WO 2020019929 A1 WO2020019929 A1 WO 2020019929A1 CN 2019093400 W CN2019093400 W CN 2019093400W WO 2020019929 A1 WO2020019929 A1 WO 2020019929A1
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Prior art keywords
antibacterial composition
chinese medicine
medicine antibacterial
traditional chinese
compound traditional
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PCT/CN2019/093400
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French (fr)
Chinese (zh)
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黄洁君
许雷
万水停
何珊
郑绍忠
陈桂成
林德钊
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广东成烨泰生物科技有限公司
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Publication of WO2020019929A1 publication Critical patent/WO2020019929A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Definitions

  • the present invention relates to the technical field of toiletries, in particular to a compound traditional Chinese medicine antibacterial composition and its application in toiletries.
  • Toiletries containing a variety of medicinal plant extracts can meet people's needs for natural, green, Health needs. However, most of the toiletries on the market are mainly cleansing, lacking real antibacterial effects, or adding prohibited ingredients, which are highly irritating and cause secondary damage to the skin.
  • a compound traditional Chinese medicine antibacterial composition includes the following components:
  • the compound traditional Chinese medicine antibacterial composition includes, by weight parts, the following components:
  • the compound traditional Chinese medicine antibacterial composition includes, by weight parts, the following components:
  • the Scutellaria baicalensis extract is prepared by the following method:
  • the method of boiling comprises adding 250ml to 350ml of water for every 15g of the root bark of Scutellaria baicalensis, and boiling for 30min to 60min until the remaining liquid is 80ml to 120ml.
  • the Alternate Leaf Melaleuca Leaf Powder is prepared by the following method:
  • Fresh branches with a single branch diameter of not more than 0.5 cm and the leaves thereon are selected, and dried, crushed and sieved to obtain it.
  • the screening uses a 60-180 mesh screen.
  • the invention also provides the application of the compound traditional Chinese medicine antibacterial composition of any of the above embodiments in the preparation of toiletries.
  • the present invention also provides a washing and protecting article, comprising a washing and protecting matrix, a solvent, and the compound traditional Chinese medicine antibacterial composition according to any one of the foregoing embodiments.
  • the invention also provides a method for preparing the toiletries, comprising the following steps:
  • the compound traditional Chinese medicine antibacterial composition is mixed with the solvent, and then added to the washing and protecting matrix.
  • the solvent is propylene glycol and / or butanediol.
  • the raw materials of the compound traditional Chinese medicine antibacterial composition of the present invention are introduced as follows:
  • Alternate Leaf Melaleuca Leaf Oil also known as Australian Tea Tree Essential Oil, is a pure natural plant extract and a medium-efficient fungicide. Alternate leaf millet leaf oil can antibacterially remove mites, condense pores, and has a strong percutaneous penetration promotion effect, which can help the absorption of other active ingredients in the component.
  • the main chemical constituents of Alpinia latifolia oil include 4-terpineol and 1,8-eucalyptol.
  • the antibacterial activity of essential oils increases with the concentration of 4-terpineol under certain conditions.
  • Eucalyptus is related to the irritation of essential oils. The lower the concentration of 1,8-eucalyptin, the less the irritation.
  • Alternate leaf white lamellar leaf powder contains volatile oil, terpineol, olefins and other ingredients. In addition to the granular powder containing more than 1% of leaf oil, it can also play a massage role in the washing process, which can remove the dry and aging skin surface Cuticle, removes dirt and sebum blocking pores, regulates sebum metabolism and improves skin environment.
  • Scutellaria baicalensis extract contains baicalin, baicalein, flavonoids, amino acids, sugars, etc., and has antibacterial, anti-inflammatory, anti-allergic, anti-oxidant, scavenging free radicals, and conditioning skin.
  • Scutellaria baicalensis extract can clear heat and detoxify, disperse stasis and hemostasis, diuretic and swelling; inhibit elastase secretion, eliminate free radicals, thereby increase skin metabolism, skin elasticity and anti-wrinkle, and play an anti-aging role; can promote brain amide secretion, and Improve sebum and make skin soft; can inhibit dermatitis, enhance skin resistance, have anti-inflammatory properties; can neutralize released histamine, and have the ability to prevent allergies.
  • Asian citronella oil contains citronellal, geraniol, and citronellol, which can be used to clean oily skin, play a role in sterilizing and anti-inflammatory, soothing muscles, relieving pain, and softening the skin.
  • Asian citronella oil has a strong scent of green pepper, refreshing the mind and eliminating brain fatigue. At the same time, it can reconcile the odor of alternate leaf white laminaria leaf oil and make the components smell more harmonious and more comfortable.
  • the present invention has the following beneficial effects:
  • each component is matched according to a specific ratio, and a variety of functional ingredients are rich in harmony and synergy with each other to kill pathogenic bacteria such as E. coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa.
  • pathogenic bacteria such as E. coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa.
  • the killing effect is obviously better than the effect of each component when used alone.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition can play a role in inhibiting pathogenic microorganisms, balancing the surface flora of the skin, isolating and removing harmful substances outside the skin, and strengthening skin cell nutrition.
  • the selected components are natural plant ingredients, green and environmentally friendly, non-toxic and side effects, mild and non-irritating.
  • the test results show that the skin cream containing the above-mentioned compound traditional Chinese medicine antibacterial composition has obvious therapeutic effect on acne, and the skin cream containing only a single medicinal ingredient has no curative effect on acne, or the cure rate is low, and the above-mentioned compound traditional Chinese medicine antibacterial
  • the skin cream of the composition can significantly improve the cure rate of acne in a short time.
  • the alternate leaf millet leaf powder used in the following examples and comparative examples is prepared by a method including the following steps:
  • the alternate leaf white lamellar oil used in the following examples and comparative examples is prepared by a method including the following steps:
  • Fresh branches and leaves of Melaleuca alternifolia were selected, heated and extracted by water distillation equipment, and condensed to separate crude oil and water to obtain crude oil.
  • the refined equipment filtered out harmful substances and retained most of the active ingredients in the Australian tea tree.
  • the Scutellaria baicalensis extract used in the following examples and comparative examples is prepared by a method including the following steps:
  • citronella oil used in the following examples and comparative examples is the same commercially available product.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the above-mentioned compound Chinese herbal medicine antibacterial composition mixed liquid is added to a cleansing matrix (water, sodium hyaluronate, succinol, hydrolyzed collagen, lipids, etc.), and stirred to make a skin cream.
  • a cleansing matrix water, sodium hyaluronate, succinol, hydrolyzed collagen, lipids, etc.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the citronella oil was weighed and dissolved in a propylene glycol solvent to obtain a compound traditional Chinese medicine antibacterial composition mixed solution having a concentration of 10% by weight.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
  • a washing and protecting matrix water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.
  • the colonies of E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans which were cultivated for 18 to 24 hours were prepared by a direct colony suspension preparation method to prepare a bacteria suspension that meets the experimental requirements.
  • the compound Chinese herbal medicine antibacterial composition provided in Examples 1 to 5 used the specific ratios of Alternate Leaf Melaleuca Leaf Powder, Alternate Leaf Melaleuca Leaf Oil, Scutellaria Baicalensis
  • the extract and citronella oil cooperate with each other and have a more obvious killing effect on pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa.
  • the compound traditional Chinese medicine antibacterial composition provided in Example 5 After 10 minutes, the sterilization rate is ⁇ 99.9%.
  • the minimum inhibitory concentration (MIC) is determined by using the micro-dilution method, using the EP tube for comparative dilution, and diluting the mixed traditional Chinese medicine antibacterial composition mixed solution prepared in Examples 1 to 5 and Comparative Examples 1 to 4 by 8 concentrations. 50%, 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, 0.39%, 0.20%, 0.10% were added to the 96-well plate, 50 ⁇ l per well.
  • the compound Chinese herbal medicine antibacterial composition provided in Examples 1 to 5 used the specific ratios of Alternate Leaf Melaleuca Leaf Powder, Alternate Leaf Melaleuca Leaf Oil, Scutellaria Baicalensis The extract and citronella oil cooperated with each other, and the minimum inhibitory concentration on S. aureus was significantly reduced.
  • Test subjects 14 to 20 years old with facial acne. There were 25 cases in each test group.
  • Test method The test is carried out for 14 days. Every morning and evening, 3 to 5 g of the skin cream prepared in Examples 1 to 5 and Comparative Examples 1 to 4 is applied to the face with acne.
  • Test criteria 1 healed: acne disappeared; 2 markedly effective: acne reduced to a little; 3 effective: acne reduced; 4 ineffective: no effect on acne.
  • the skin cream provided in Examples 1 to 5 has a relatively obvious effect of eliminating acne.
  • the skin cream provided in Example 5 has the best effect, which illustrates the present invention.
  • the compound Chinese medicine antibacterial composition with preferred component content has better effect.
  • each component is matched according to a specific ratio, and a variety of functional ingredients are rich in harmony and synergy with each other, and play a role in inhibiting pathogenic microorganisms, balancing the surface flora of the skin, isolating and removing harmful substances on the skin and Strengthen the nutritional effect on skin cells.
  • the above-mentioned compound traditional Chinese medicine antibacterial composition the selected components are all natural plant ingredients, green and environmental protection, no toxic and side effects, mild and non-irritating.

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Abstract

A compound Chinese traditional medicine antibacterial composition and an application thereof in preparing toiletry products; the composition comprises 1-10 parts of Melaleuca alternifolia leaf powder, 0.1-5 parts of Melaleuca alternifolia leaf oil, 1-10 parts of Scutellaria baicalensis extract, and 0.05-0.5 parts of Cymbopogon nardus oil. The composition has the effects of inhibiting pathogenic microorganisms, balancing skin surface flora, isolating and removing harmful substances on the skin, and enhancing the nourishment of the skin cells.

Description

复方中药抗菌组合物及其在洗护产品中的应用Compound traditional Chinese medicine antibacterial composition and application thereof in washing products 技术领域Technical field
本发明涉及洗护用品技术领域,特别是涉及一种复方中药抗菌组合物及其在洗护产品中的应用。The present invention relates to the technical field of toiletries, in particular to a compound traditional Chinese medicine antibacterial composition and its application in toiletries.
背景技术Background technique
随着人们消费意识的提升,消费者在选用洗护清洁品时越来越重视产品的安全性,追求天然护肤,含有多种药用植物提取物的洗护用品可以满足人们对于天然、绿色、健康的需求。然而,市场上大部分洗护用品都是以清洁为主,缺乏真正的抗菌效果,或添加违禁成分,刺激性强,损伤皮肤造成二次伤害。With the improvement of people's consumption awareness, consumers are paying more and more attention to the safety of products when choosing washing and cleaning products, and pursuing natural skin care. Toiletries containing a variety of medicinal plant extracts can meet people's needs for natural, green, Health needs. However, most of the toiletries on the market are mainly cleansing, lacking real antibacterial effects, or adding prohibited ingredients, which are highly irritating and cause secondary damage to the skin.
发明内容Summary of the Invention
基于此,有必要提供一种天然的能够有效抗菌的复方中药抗菌组合物及其在洗护产品中的应用。Based on this, it is necessary to provide a natural compound traditional Chinese medicine antibacterial composition capable of effectively antibacterial and its application in washing products.
一种复方中药抗菌组合物,按重量份计,包括以下组分:A compound traditional Chinese medicine antibacterial composition, based on parts by weight, includes the following components:
Figure PCTCN2019093400-appb-000001
Figure PCTCN2019093400-appb-000001
在其中一个实施例中,所述复方中药抗菌组合物,按重量份计,包括以下组分:In one embodiment, the compound traditional Chinese medicine antibacterial composition includes, by weight parts, the following components:
Figure PCTCN2019093400-appb-000002
Figure PCTCN2019093400-appb-000002
在其中一个实施例中,所述复方中药抗菌组合物,按重量份计,包括以下组分:In one embodiment, the compound traditional Chinese medicine antibacterial composition includes, by weight parts, the following components:
Figure PCTCN2019093400-appb-000003
Figure PCTCN2019093400-appb-000003
在其中一个实施例中,所述黄芩提取液由如下方法制备得到:In one embodiment, the Scutellaria baicalensis extract is prepared by the following method:
称取黄芩根皮加水熬制,滤除固体,即得。Weigh the root bark of Scutellaria baicalensis and boil it with water, filter out the solids and obtain.
在其中一个实施例中,所述熬制的方法包括:每15g所述黄芩根皮加入250ml~350ml水,熬制30min~60min至余液为80ml~120ml。In one of the embodiments, the method of boiling comprises adding 250ml to 350ml of water for every 15g of the root bark of Scutellaria baicalensis, and boiling for 30min to 60min until the remaining liquid is 80ml to 120ml.
在其中一个实施例中,所述互生叶白千层叶粉由如下方法制备得到:In one embodiment, the Alternate Leaf Melaleuca Leaf Powder is prepared by the following method:
选取互生叶白千层单枝直径不大于0.5cm的新鲜枝条及其上的叶片,晒干、粉碎、过筛,即得。Fresh branches with a single branch diameter of not more than 0.5 cm and the leaves thereon are selected, and dried, crushed and sieved to obtain it.
在其中一个实施例中,所述过筛选用60目~180目筛网。In one embodiment, the screening uses a 60-180 mesh screen.
本发明还提供上述任一实施例的复方中药抗菌组合物在制备洗护用品中的应用。The invention also provides the application of the compound traditional Chinese medicine antibacterial composition of any of the above embodiments in the preparation of toiletries.
本发明还提供一种洗护用品,其包含洗护基质、溶剂以及上述任一实施例所述的复方中药抗菌组合物。The present invention also provides a washing and protecting article, comprising a washing and protecting matrix, a solvent, and the compound traditional Chinese medicine antibacterial composition according to any one of the foregoing embodiments.
本发明还提供一种所述的洗护用品的制备方法,包括以下步骤:The invention also provides a method for preparing the toiletries, comprising the following steps:
将所述复方中药抗菌组合物混合于所述溶剂,再加入所述洗护基质中。The compound traditional Chinese medicine antibacterial composition is mixed with the solvent, and then added to the washing and protecting matrix.
在其中一个实施例中,所述溶剂为丙二醇和/或丁二醇。In one embodiment, the solvent is propylene glycol and / or butanediol.
本发明的复方中药抗菌组合物的原料介绍如下:The raw materials of the compound traditional Chinese medicine antibacterial composition of the present invention are introduced as follows:
互生叶白千层叶油又叫澳洲茶树精油,为纯天然植物提取物,是中高效的杀菌剂。互生叶白千层叶油能够抗菌除螨、收敛毛孔,并且有很强的经皮渗透促进作用,能帮助组分中其他有效成分的吸收。互生叶白千层叶油的主要化学成分包括了4-松油醇和1,8-桉叶素,精油的抗菌活性在一定条件下随着4-松油醇浓度增加而增强,1,8-桉叶素与精油的刺激性相关,1,8-桉叶素浓度越低,刺激性越小。Alternate Leaf Melaleuca Leaf Oil, also known as Australian Tea Tree Essential Oil, is a pure natural plant extract and a medium-efficient fungicide. Alternate leaf millet leaf oil can antibacterially remove mites, condense pores, and has a strong percutaneous penetration promotion effect, which can help the absorption of other active ingredients in the component. The main chemical constituents of Alpinia latifolia oil include 4-terpineol and 1,8-eucalyptol. The antibacterial activity of essential oils increases with the concentration of 4-terpineol under certain conditions. Eucalyptus is related to the irritation of essential oils. The lower the concentration of 1,8-eucalyptin, the less the irritation.
互生叶白千层叶粉含有挥发油、松油醇、烯类等成分,颗粒状粉末除含有超过1%的叶油外,在洗护过程中还可起到按摩作用,可以去除皮肤表面干燥老化角质层,清除阻塞毛孔的污垢和皮脂,调节皮脂代谢,改善肌肤环境。Alternate leaf white lamellar leaf powder contains volatile oil, terpineol, olefins and other ingredients. In addition to the granular powder containing more than 1% of leaf oil, it can also play a massage role in the washing process, which can remove the dry and aging skin surface Cuticle, removes dirt and sebum blocking pores, regulates sebum metabolism and improves skin environment.
黄芩提取物含黄芩苷、黄芩素、黄酮类化合物、氨基酸、糖类等,具有抑菌抗炎、抗过敏、抗氧化、清除自由基以及调理皮肤等作用。黄芩提取物能清热解毒、散淤止血、利尿消肿;能抑制弹性蛋白酶分泌,消除自由基,从而增加皮肤新陈代谢、皮肤弹性和抗皱性,起到抗衰老的作用;能促进脑酰胺分泌,而改善皮脂使皮肤柔润;能抑制皮炎、增强皮肤的抵抗力,具有抗炎性;能中和释放的组胺,具有防止过敏的能力。Scutellaria baicalensis extract contains baicalin, baicalein, flavonoids, amino acids, sugars, etc., and has antibacterial, anti-inflammatory, anti-allergic, anti-oxidant, scavenging free radicals, and conditioning skin. Scutellaria baicalensis extract can clear heat and detoxify, disperse stasis and hemostasis, diuretic and swelling; inhibit elastase secretion, eliminate free radicals, thereby increase skin metabolism, skin elasticity and anti-wrinkle, and play an anti-aging role; can promote brain amide secretion, and Improve sebum and make skin soft; can inhibit dermatitis, enhance skin resistance, have anti-inflammatory properties; can neutralize released histamine, and have the ability to prevent allergies.
亚香茅油含有香茅醛、香叶醇和香茅醇等成分,可用于清洁油性皮肤,起到杀菌消炎、舒筋活络、止痛、使皮肤软化的作用。亚香茅油具有浓郁的山椒香气,清新头脑,消除大脑疲劳,同时能够调和互生叶白千层叶油的气味,使 组分气味和谐更加舒适。Asian citronella oil contains citronellal, geraniol, and citronellol, which can be used to clean oily skin, play a role in sterilizing and anti-inflammatory, soothing muscles, relieving pain, and softening the skin. Asian citronella oil has a strong scent of green pepper, refreshing the mind and eliminating brain fatigue. At the same time, it can reconcile the odor of alternate leaf white laminaria leaf oil and make the components smell more harmonious and more comfortable.
与现有方案相比,本发明具有以下有益效果:Compared with the existing solutions, the present invention has the following beneficial effects:
上述复方中药抗菌组合物,各组分按照特定比例进行搭配,富含的多种功效成分互相调和、协同,对大肠杆菌、金黄色葡萄球菌、白色念珠菌和绿脓杆菌等致病菌的杀灭效果明显优于各组分单独使用时的效果。In the above-mentioned compound Chinese medicine antibacterial composition, each component is matched according to a specific ratio, and a variety of functional ingredients are rich in harmony and synergy with each other to kill pathogenic bacteria such as E. coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa. The killing effect is obviously better than the effect of each component when used alone.
上述复方中药抗菌组合物,可起到抑制致病微生物、平衡皮肤表面菌群、隔离和去除皮肤外的有害物质和加强皮肤细胞营养的作用。所选组分均为天然植物成分,绿色环保,无毒副作用,温和无刺激。The above-mentioned compound traditional Chinese medicine antibacterial composition can play a role in inhibiting pathogenic microorganisms, balancing the surface flora of the skin, isolating and removing harmful substances outside the skin, and strengthening skin cell nutrition. The selected components are natural plant ingredients, green and environmentally friendly, non-toxic and side effects, mild and non-irritating.
试验结果表明,含有上述复方中药抗菌组合物的护肤霜对痤疮具有明显的治疗效果,只含有单一药物成分的护肤霜,或对痤疮不具有治愈效果,或治愈率低,而含有上述复方中药抗菌组合物的护肤霜可在短时间内明显提高痤疮治愈率。The test results show that the skin cream containing the above-mentioned compound traditional Chinese medicine antibacterial composition has obvious therapeutic effect on acne, and the skin cream containing only a single medicinal ingredient has no curative effect on acne, or the cure rate is low, and the above-mentioned compound traditional Chinese medicine antibacterial The skin cream of the composition can significantly improve the cure rate of acne in a short time.
具体实施方式detailed description
为了便于理解本发明,下面将结合具体实施例对本发明进行更全面的描述。但是,本发明可以以许多不同的形式来实现,并不限于本文所描述的实施例。相反地,提供这些实施例的目的是使对本发明的公开内容的理解更加透彻全面。In order to facilitate understanding of the present invention, the present invention will be described more fully with reference to specific embodiments. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a thorough understanding of the present disclosure.
除非另有定义,本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具体的实施例的目的,不是旨在于限制本发明。Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to limit the invention.
以下各实施例和对比例采用的互生叶白千层叶粉由包括以下步骤的方法制备得到:The alternate leaf millet leaf powder used in the following examples and comparative examples is prepared by a method including the following steps:
选取互生叶白千层单枝直径不大于0.5cm的新鲜枝条及其上的叶片,用清水洗净,晒干后,剪切枝条至每段约2cm,用粉碎机将其粉碎、用60至180目筛网过筛3次,即得。Select fresh branches with a single branch not larger than 0.5 cm in diameter and the leaves on them, wash them with water, dry them, cut the branches to about 2 cm per section, pulverize them with a grinder, and use 60 to Sieving 180 mesh screen 3 times, that's it.
以下各实施例和对比例采用的互生叶白千层叶油由包括以下步骤的方法制备得到:The alternate leaf white lamellar oil used in the following examples and comparative examples is prepared by a method including the following steps:
选取新鲜互生叶白千层枝叶,通过水蒸馏设备加热蒸馏萃取,冷凝,使油水分离得到提取粗油,经精制设备滤除有害物质,保留了澳洲茶树中大部分的有效成分。Fresh branches and leaves of Melaleuca alternifolia were selected, heated and extracted by water distillation equipment, and condensed to separate crude oil and water to obtain crude oil. The refined equipment filtered out harmful substances and retained most of the active ingredients in the Australian tea tree.
以下各实施例和对比例采用的黄芩提取液由包括以下步骤的方法制备得到:The Scutellaria baicalensis extract used in the following examples and comparative examples is prepared by a method including the following steps:
称取黄芩根皮每15g所述黄芩根皮加入250ml~350ml水,熬制30min~60min至余液为80ml~120ml,用50目滤网过滤,得到黄芩提取液,密封置于4℃冰箱中储存。Weigh the root bark of Scutellaria baicalensis and add 250ml to 350ml of water for every 15g of the root bark of Scutellaria baicalensis. Boil for 30min to 60min until the remaining liquid is 80ml to 120ml. Filter through a 50-mesh filter to obtain the Scutellaria baicalensis extract. Seal it in a refrigerator at 4 ° C. Save.
以下各实施例和对比例采用的亚香茅油为同一市售产品。The citronella oil used in the following examples and comparative examples is the same commercially available product.
实施例1Example 1
称取互生叶白千层叶粉1g、互生叶白千层叶油5g、黄芩提取液10g和亚香茅油0.05g,用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weigh 1g of S. alternifolia leaf powder, 5g of S. alternifolia leaf oil, 10g of Scutellaria baicalensis extract and 0.05g of citronella oil, and dissolve it in a propylene glycol solvent to obtain a 10% by weight compound Chinese medicine antibacterial composition mixture.
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
实施例2Example 2
称取互生叶白千层叶粉10g、互生叶白千层叶油0.1g、黄芩提取液1g和亚香茅油0.5g,用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weigh 10g of Alternate Leaf Melaleuca Leaf Powder, 0.1g of Alternate Leaf Melaleuca Leaf Oil, 1g of Scutellaria Baicalensis Extract and 0.5g of Citronella Oil, and dissolve it in a propylene glycol solvent to obtain a compound traditional Chinese medicine antibacterial composition mixed solution with a concentration of 10% by weight. .
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
实施例3Example 3
称取互生叶白千层叶粉5g、互生叶白千层叶油3g、黄芩提取液8g和亚香茅油0.05g,用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weigh 5g of S. alternifolia leaf powder, 3g of S. alternifolia leaf oil, 8g of Scutellaria baicalensis extract and 0.05g of citronella oil, and dissolve it in a propylene glycol solvent to obtain a 10% by weight compound traditional Chinese medicine antibacterial composition mixture.
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
实施例4Example 4
称取互生叶白千层叶粉8g、互生叶白千层叶油0.5g、黄芩提取液3g和亚香茅油0.3g,用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weigh 8g of Alternate Leaf Melaleuca Leaf Powder, 0.5g of Alternate Leaf Melaleuca Leaf Oil, 3g of Scutellaria Baicalensis Extract and 0.3g of Citronella Oil, and dissolve it in a propylene glycol solvent to obtain a compound traditional Chinese medicine antibacterial composition mixed solution with a concentration of 10% by weight. .
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
实施例5Example 5
称取互生叶白千层叶粉5g、互生叶白千层叶油2.5g、黄芩提取液5g和亚香茅油0.25g,用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weigh 5g of Alternate Leaf Melaleuca Leaf Powder, 2.5g of Alternate Leaf Melaleuca Leaf Oil, 5g of Scutellaria Baicalensis Extract and 0.25g of Citronella Oil, and dissolve it in a propylene glycol solvent to obtain a compound traditional Chinese medicine antibacterial composition mixed solution with a concentration of 10% by weight. .
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二 醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound Chinese herbal medicine antibacterial composition mixed liquid is added to a cleansing matrix (water, sodium hyaluronate, succinol, hydrolyzed collagen, lipids, etc.), and stirred to make a skin cream.
对比例1Comparative Example 1
称取互生叶白千层叶粉用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weighing the powder of Alternaria alternifolia powder with propylene glycol solvent to obtain a compound traditional Chinese medicine antibacterial composition mixed solution with a concentration of 10% by weight.
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
对比例2Comparative Example 2
称取互生叶白千层叶油用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weigh the mixed Chinese herbal medicine antibacterial composition mixed solution of the S. alternifolia leaf oil with propylene glycol solvent.
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
对比例3Comparative Example 3
称取黄芩提取液用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混合液。Weigh the Scutellaria baicalensis extract with a propylene glycol solvent to obtain a compound traditional Chinese medicine antibacterial composition mixed solution with a concentration of 10% by weight.
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
对比例4Comparative Example 4
称取亚香茅油用丙二醇溶剂溶解得浓度为10wt%的复方中药抗菌组合物混 合液。The citronella oil was weighed and dissolved in a propylene glycol solvent to obtain a compound traditional Chinese medicine antibacterial composition mixed solution having a concentration of 10% by weight.
将上述复方中药抗菌组合物混合液加入洗护基质(水、透明质酸钠、丁二醇、水解胶原蛋白和脂质等)中,搅拌均匀,制成护肤霜。The above-mentioned compound traditional Chinese medicine antibacterial composition mixed liquid is added to a washing and protecting matrix (water, sodium hyaluronate, butanediol, hydrolyzed collagen and lipid, etc.), and the mixture is evenly mixed to prepare a skin cream.
悬液定量杀菌试验Suspension quantitative sterilization test
取培养18~24h的大肠杆菌、金黄色葡萄球菌、绿脓杆菌、白色念珠菌菌落,采用直接菌落悬液配制法,制备成符合实验要求的菌悬液。The colonies of E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans which were cultivated for 18 to 24 hours were prepared by a direct colony suspension preparation method to prepare a bacteria suspension that meets the experimental requirements.
在无菌试管内加入1ml试验菌悬液和4ml实施例1~5及对比例1~4制备的复方中药抗菌组合物混合液,混匀,恒温至(20±1℃),作用5min和10min。取0.5ml样液加入到4.5ml中和剂(2%吐温-80+0.5%卵磷脂+1%甘氨酸+0.03mol/L PBS)试管内混匀,中和作用10min。分别吸取1.0ml样液,按活菌培养计数方法测定存活菌数,计算杀灭率。如平板上生长的菌落数较多时,可进行系列10倍稀释后,再进行活菌培养计数。同时用稀释液代替实施例1~5及对比例1~4制备的复方中药抗菌组合物混合液,进行平行试验,作为阳性对照。结果如下:In a sterile test tube, add 1 ml of the test bacteria suspension and 4 ml of the compound traditional Chinese medicine antibacterial composition mixture prepared in Examples 1 to 5 and Comparative Examples 1 to 4, mix well, and keep the temperature constant to (20 ± 1 ° C) for 5 minutes and 10 minutes. . Take 0.5ml sample solution and add it to 4.5ml neutralizer (2% Tween-80 + 0.5% lecithin + 1% glycine + 0.03mol / L PBS) test tube, mix and neutralize for 10min. Take 1.0ml of the sample solution and measure the number of viable bacteria according to the live bacteria culture counting method to calculate the killing rate. If there are a large number of colonies growing on the plate, a serial 10-fold dilution can be performed and then counted for live bacteria culture. At the same time, the diluted liquid was used in place of the mixed liquid of the traditional Chinese medicine antibacterial composition prepared in Examples 1 to 5 and Comparative Examples 1 to 4, and a parallel test was performed as a positive control. The results are as follows:
实施例1Example 1
Figure PCTCN2019093400-appb-000004
Figure PCTCN2019093400-appb-000004
实施例2Example 2
Figure PCTCN2019093400-appb-000005
Figure PCTCN2019093400-appb-000005
Figure PCTCN2019093400-appb-000006
Figure PCTCN2019093400-appb-000006
实施例3Example 3
Figure PCTCN2019093400-appb-000007
Figure PCTCN2019093400-appb-000007
实施例4Example 4
Figure PCTCN2019093400-appb-000008
Figure PCTCN2019093400-appb-000008
实施例5Example 5
Figure PCTCN2019093400-appb-000009
Figure PCTCN2019093400-appb-000009
对比例1Comparative Example 1
Figure PCTCN2019093400-appb-000010
Figure PCTCN2019093400-appb-000010
对比例2Comparative Example 2
Figure PCTCN2019093400-appb-000011
Figure PCTCN2019093400-appb-000011
Figure PCTCN2019093400-appb-000012
Figure PCTCN2019093400-appb-000012
对比例3Comparative Example 3
Figure PCTCN2019093400-appb-000013
Figure PCTCN2019093400-appb-000013
对比例4Comparative Example 4
Figure PCTCN2019093400-appb-000014
Figure PCTCN2019093400-appb-000014
从表中数据可见,与各组分单独使用相比,实施例1~5所提供的复方中药抗菌组合物通过特定配比的互生叶白千层叶粉、互生叶白千层叶油、黄芩提取液和亚香茅油相互协同,对大肠杆菌、金黄色葡萄球菌、白色念珠菌和绿脓杆菌等致病菌具有更加明显的杀灭效果,其中实施例5所提供的复方中药抗菌组合物作用10min,杀菌率≧99.9%。As can be seen from the data in the table, compared with the individual components, the compound Chinese herbal medicine antibacterial composition provided in Examples 1 to 5 used the specific ratios of Alternate Leaf Melaleuca Leaf Powder, Alternate Leaf Melaleuca Leaf Oil, Scutellaria Baicalensis The extract and citronella oil cooperate with each other and have a more obvious killing effect on pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa. The compound traditional Chinese medicine antibacterial composition provided in Example 5 After 10 minutes, the sterilization rate is ≧ 99.9%.
对金黄色葡萄球菌最低抑制浓度(MIC值)的测定Determination of the minimum inhibitory concentration (MIC value) of Staphylococcus aureus
测试方法:最小抑制浓度(MIC)测定采用微量稀释法,用EP管对比稀释,将实施例1~5及对比例1~4制备的复方中药抗菌组合物混合液稀释8个浓度,各管浓度依次为50%、25%、12.5%、6.25%、3.13%、1.56%、0.78%、0.39%、0.20%、0.10%,加入96孔板中,每孔50μl。将稀释好的金黄色葡萄球菌菌液 (10 6cfu/ml)加入已有实施例1~5及对比例1~4制备的复方中药抗菌组合物混合液的孔中,每孔50ul,盖好,置35℃中培养24h。以肉眼观察,药物最低浓度管无细菌生长者,即为受试菌的MIC值。结果如下: Test method: The minimum inhibitory concentration (MIC) is determined by using the micro-dilution method, using the EP tube for comparative dilution, and diluting the mixed traditional Chinese medicine antibacterial composition mixed solution prepared in Examples 1 to 5 and Comparative Examples 1 to 4 by 8 concentrations. 50%, 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, 0.39%, 0.20%, 0.10% were added to the 96-well plate, 50 μl per well. Add the diluted Staphylococcus aureus bacterial solution (10 6 cfu / ml) to the wells of the compound traditional Chinese medicine antibacterial composition mixed solution prepared in Examples 1 to 5 and Comparative Examples 1 to 4, 50ul per well, and cover Incubate at 35 ° C for 24h. Observation with the naked eye, the lowest concentration of the drug tube without bacteria growth, that is, the MIC value of the test bacteria. The results are as follows:
Figure PCTCN2019093400-appb-000015
Figure PCTCN2019093400-appb-000015
从表中数据可见,与各组分单独使用相比,实施例1~5所提供的复方中药抗菌组合物通过特定配比的互生叶白千层叶粉、互生叶白千层叶油、黄芩提取液和亚香茅油相互协同,对金黄色葡萄球菌最低抑制浓度有明显降低。As can be seen from the data in the table, compared with the individual components, the compound Chinese herbal medicine antibacterial composition provided in Examples 1 to 5 used the specific ratios of Alternate Leaf Melaleuca Leaf Powder, Alternate Leaf Melaleuca Leaf Oil, Scutellaria Baicalensis The extract and citronella oil cooperated with each other, and the minimum inhibitory concentration on S. aureus was significantly reduced.
青少年面部痤疮治疗测试Teen Facial Acne Treatment Test
测试对象:14岁~20岁的患有面部痤疮的青少年。每个测试组为25例。Test subjects: 14 to 20 years old with facial acne. There were 25 cases in each test group.
测试方法:测试进行14天,每天早晚各取实施例1~5及对比例1~4空白制得的护肤霜3~5g涂抹到有痤疮的面部位置。Test method: The test is carried out for 14 days. Every morning and evening, 3 to 5 g of the skin cream prepared in Examples 1 to 5 and Comparative Examples 1 to 4 is applied to the face with acne.
测试标准:①痊愈:痤疮消失;②显效:痤疮减轻至少许;③有效:痤疮减轻;④无效:对痤疮没有起到作用。Test criteria: ① healed: acne disappeared; ② markedly effective: acne reduced to a little; ③ effective: acne reduced; ④ ineffective: no effect on acne.
治疗测试效果见下表。The effect of treatment test is shown in the table below.
样品sample 痊愈get well 显效Marked effect 有效effective 无效invalid 痊愈率Recovery rate 总有效率Total efficiency
实施例1Example 1 88 77 33 77 32%32% 72%72%
实施例2Example 2 1111 44 44 66 44%44% 76%76%
实施例3Example 3 1515 22 55 33 60%60% 88%88%
实施例4Example 4 1313 66 33 33 52%52% 88%88%
实施例5Example 5 1515 66 33 11 60%60% 96%96%
对比例1Comparative Example 1 11 55 66 1313 8%8% 48%48%
对比例2Comparative Example 2 33 55 66 1111 12%12% 56%56%
对比例3Comparative Example 3 00 22 77 1616 00 36%36%
对比例4Comparative Example 4 00 00 1010 1515 00 40%40%
从表中数据可见,与对比例1~4相比,实施例1~5所提供的护肤霜,消除痤疮的功效相对明显,其中实施例5所提供的护肤霜的效果最好,说明本发明优选的组分含量的复方中药抗菌组合物效果更佳。在本发明产品测试过程中,未发现毒副作用,没有一例出现过敏反应,仅有3例局部皮肤有溃烂者,在使用头两天有轻微刺痛感,第三天后消失。As can be seen from the data in the table, compared with the comparative examples 1 to 4, the skin cream provided in Examples 1 to 5 has a relatively obvious effect of eliminating acne. The skin cream provided in Example 5 has the best effect, which illustrates the present invention. The compound Chinese medicine antibacterial composition with preferred component content has better effect. During the testing of the product of the present invention, no toxic or side effects were found, no allergic reaction occurred, and only 3 cases of localized skin ulceration had a slight tingling sensation during the first two days of use, and disappeared after the third day.
上述复方中药抗菌组合物,各组分按照特定比例进行搭配,富含的多种功效成分互相调和、协同,起到抑制致病微生物、平衡皮肤表面菌群、隔离和去除皮肤上的有害物质和加强对皮肤细胞的营养作用。In the above-mentioned compound Chinese medicine antibacterial composition, each component is matched according to a specific ratio, and a variety of functional ingredients are rich in harmony and synergy with each other, and play a role in inhibiting pathogenic microorganisms, balancing the surface flora of the skin, isolating and removing harmful substances on the skin and Strengthen the nutritional effect on skin cells.
上述复方中药抗菌组合物,所选组分均为天然植物成分,绿色环保,无毒副作用,温和不刺激。The above-mentioned compound traditional Chinese medicine antibacterial composition, the selected components are all natural plant ingredients, green and environmental protection, no toxic and side effects, mild and non-irritating.
以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。The technical features of the embodiments described above can be arbitrarily combined. In order to simplify the description, all possible combinations of the technical features in the above embodiments have not been described. However, as long as there is no contradiction in the combination of these technical features, It should be considered as the scope described in this specification.
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。The above-mentioned embodiments only express several implementation manners of the present invention, and their descriptions are more specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be noted that, for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can be made, which all belong to the protection scope of the present invention. Therefore, the protection scope of the invention patent shall be subject to the appended claims.

Claims (10)

  1. 一种复方中药抗菌组合物,其特征在于,按重量份计,包括以下组分:A compound traditional Chinese medicine antibacterial composition, characterized by comprising, by weight parts, the following components:
    Figure PCTCN2019093400-appb-100001
    Figure PCTCN2019093400-appb-100001
  2. 如权利要求1所述的复方中药抗菌组合物,其特征在于,按重量份计,包括以下组分:The compound traditional Chinese medicine antibacterial composition according to claim 1, characterized by comprising, by weight parts, the following components:
    Figure PCTCN2019093400-appb-100002
    Figure PCTCN2019093400-appb-100002
  3. 如权利要求2所述的复方中药抗菌组合物,其特征在于,按重量份计,包括以下组分:The compound traditional Chinese medicine antibacterial composition according to claim 2, characterized by comprising, by weight parts, the following components:
    Figure PCTCN2019093400-appb-100003
    Figure PCTCN2019093400-appb-100003
  4. 如权利要求1~3任一项所述的复方中药抗菌组合物,其特征在于,所述黄芩提取液由如下方法制备得到:The compound traditional Chinese medicine antibacterial composition according to any one of claims 1 to 3, wherein the Scutellaria baicalensis extract is prepared by the following method:
    称取黄芩根皮加水熬制,滤除固体,即得。Weigh the root bark of Scutellaria baicalensis and boil it with water, filter out the solids and obtain.
  5. 如权利要求4所述的复方中药抗菌组合物,其特征在于,所述熬制的方 法包括:每15g所述黄芩根皮加入250ml~350ml水,熬制30min~60min至余液为80ml~120ml。The compound traditional Chinese medicine antibacterial composition according to claim 4, characterized in that the method of boiling comprises: adding 250ml to 350ml of water for every 15g of Scutellaria baicalensis root bark, and boiling for 30min to 60min until the remaining liquid is 80ml to 120ml .
  6. 如权利要求1~3任一项所述的复方中药抗菌组合物,其特征在于,所述互生叶白千层叶粉由如下方法制备得到:The compound traditional Chinese medicine antibacterial composition according to any one of claims 1 to 3, characterized in that the intergrowth leaf white lamellar leaf powder is prepared by the following method:
    选取互生叶白千层单枝直径不大于0.5cm的新鲜枝条及其上的叶片,晒干、粉碎、过筛,即得。Fresh branches with a single branch diameter of not more than 0.5 cm and the leaves thereon are selected, and dried, crushed and sieved to obtain it.
  7. 如权利要求6所述的复方中药抗菌组合物,其特征在于,所述过筛选用60目~180目筛网。The compound traditional Chinese medicine antibacterial composition according to claim 6, characterized in that the screening uses a 60-180 mesh screen.
  8. 如权利要求1~7任一项所述的复方中药抗菌组合物在制备洗护用品中的应用。Application of the compound traditional Chinese medicine antibacterial composition according to any one of claims 1 to 7 in the preparation of toiletries.
  9. 一种洗护用品,其特征在于,包含洗护基质、溶剂以及如权利要求1~7任一项所述的复方中药抗菌组合物。A washing and care article, comprising a washing and care base, a solvent, and the compound Chinese medicine antibacterial composition according to any one of claims 1 to 7.
  10. 一种如权利要求9所述的洗护用品的制备方法,其特征在于,包括以下步骤:The preparation method of the toiletries according to claim 9, further comprising the following steps:
    将所述复方中药抗菌组合物混合于所述溶剂,再加入所述洗护基质中。The compound traditional Chinese medicine antibacterial composition is mixed with the solvent, and then added to the washing and protecting matrix.
PCT/CN2019/093400 2018-07-27 2019-06-27 Compound chinese traditional medicine antibacterial composition and application thereof in toiletry products WO2020019929A1 (en)

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