CN111991297A - Anti-aging wrinkle-removing composition and preparation method and application thereof - Google Patents
Anti-aging wrinkle-removing composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN111991297A CN111991297A CN202010968429.5A CN202010968429A CN111991297A CN 111991297 A CN111991297 A CN 111991297A CN 202010968429 A CN202010968429 A CN 202010968429A CN 111991297 A CN111991297 A CN 111991297A
- Authority
- CN
- China
- Prior art keywords
- aging
- wrinkle
- parts
- extract
- removing composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 127
- 239000000203 mixture Substances 0.000 title claims abstract description 108
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 230000001153 anti-wrinkle effect Effects 0.000 claims abstract description 101
- 239000000284 extract Substances 0.000 claims abstract description 89
- 108010073771 Soybean Proteins Proteins 0.000 claims abstract description 34
- 229940072008 glycyrrhiza glabra extract Drugs 0.000 claims abstract description 34
- 238000003756 stirring Methods 0.000 claims abstract description 34
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 31
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 31
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 31
- 235000008434 ginseng Nutrition 0.000 claims abstract description 31
- 235000019710 soybean protein Nutrition 0.000 claims abstract description 16
- 239000002904 solvent Substances 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract 2
- 239000006071 cream Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 235000013336 milk Nutrition 0.000 claims description 15
- 239000008267 milk Substances 0.000 claims description 15
- 210000004080 milk Anatomy 0.000 claims description 15
- 241001170080 Lonicera hypoglauca Species 0.000 claims description 12
- 241000366182 Melaleuca alternifolia Species 0.000 claims description 9
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 8
- 229920001436 collagen Polymers 0.000 claims description 8
- 229910003472 fullerene Inorganic materials 0.000 claims description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 8
- IHRKJQSLKLYWBQ-QKDODKLFSA-N (2s)-2-[[(2s)-1-[(2s)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O IHRKJQSLKLYWBQ-QKDODKLFSA-N 0.000 claims description 7
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims description 7
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 claims description 7
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims description 7
- 229940059958 centella asiatica extract Drugs 0.000 claims description 7
- 241000512259 Ascophyllum nodosum Species 0.000 claims description 5
- 239000003973 paint Substances 0.000 claims description 4
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- MFYAQFYIDXXKQG-MLCQCVOFSA-N (2s)-2-[[(2s)-4-amino-2-[[(2s)-2-[[(2s)-2-(hexadecanoylamino)-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]propanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(O)=O MFYAQFYIDXXKQG-MLCQCVOFSA-N 0.000 claims description 2
- 240000005002 Erythronium dens canis Species 0.000 claims description 2
- 240000004181 Eucalyptus cladocalyx Species 0.000 claims description 2
- 108010075308 N-palmitoyl-seryl-seryl-asparaginyl-alanine Proteins 0.000 claims description 2
- 108010038807 Oligopeptides Proteins 0.000 claims description 2
- 102000015636 Oligopeptides Human genes 0.000 claims description 2
- 241000628997 Flos Species 0.000 claims 1
- 241001491705 Macrocystis pyrifera Species 0.000 claims 1
- 241000220317 Rosa Species 0.000 claims 1
- 241001441723 Takifugu Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 42
- 238000009776 industrial production Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 41
- 230000037303 wrinkles Effects 0.000 description 36
- 241000208340 Araliaceae Species 0.000 description 29
- 230000032683 aging Effects 0.000 description 22
- 230000003020 moisturizing effect Effects 0.000 description 19
- 229940001941 soy protein Drugs 0.000 description 18
- 150000003254 radicals Chemical class 0.000 description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
- 239000000686 essence Substances 0.000 description 14
- 239000006210 lotion Substances 0.000 description 14
- 230000037393 skin firmness Effects 0.000 description 14
- 230000009286 beneficial effect Effects 0.000 description 13
- 230000037394 skin elasticity Effects 0.000 description 13
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 12
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 11
- 230000002195 synergetic effect Effects 0.000 description 10
- 230000002292 Radical scavenging effect Effects 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 4
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- 241000220433 Albizia Species 0.000 description 3
- 235000011438 Albizia odoratissima Nutrition 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- KIUKXJAPPMFGSW-YXBJCWEESA-N (2s,4s,5r,6s)-6-[(2s,3r,5s,6r)-3-acetamido-2-[(3s,4r,5r,6r)-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@@H]3[C@@H]([C@@H](O)C(O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)C(C(O)=O)O1 KIUKXJAPPMFGSW-YXBJCWEESA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 241001491708 Macrocystis Species 0.000 description 2
- 235000001167 Melaleuca cajuputi Nutrition 0.000 description 2
- 241000378544 Melaleuca quinquenervia Species 0.000 description 2
- 235000017710 Melaleuca viridiflora Nutrition 0.000 description 2
- 240000008530 Rosa canina Species 0.000 description 2
- 235000000539 Rosa canina Nutrition 0.000 description 2
- 235000010337 Rosa dumalis Nutrition 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000002079 cooperative effect Effects 0.000 description 2
- 229920006037 cross link polymer Polymers 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 229940051250 hexylene glycol Drugs 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 235000020712 soy bean extract Nutrition 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000011885 synergistic combination Substances 0.000 description 2
- 240000007185 Albizia julibrissin Species 0.000 description 1
- 235000011468 Albizia julibrissin Nutrition 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241000428811 Alternanthera Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 240000001080 Grifola frondosa Species 0.000 description 1
- 235000007710 Grifola frondosa Nutrition 0.000 description 1
- 241000024149 Herminium monorchis Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 229940073736 biosaccharide gum-4 Drugs 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 229940120147 rosa canina seed extract Drugs 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The application relates to the field of skin care products, and particularly discloses an anti-aging and wrinkle-removing composition, and a preparation method and application thereof. The anti-aging and wrinkle-removing composition comprises the following components in parts by mass: 30-40 parts of glycyrrhiza glabra extract; 50-65 parts of hydrolyzed soybean protein; 5-10 parts of ginseng fruit extract; 15-20 parts of a solvent; the preparation method comprises the following steps: and (3) uniformly stirring and mixing the components of the anti-aging and wrinkle-removing composition to obtain the anti-aging and wrinkle-removing composition. The composition can be added into skin care products, and has the advantages of more comprehensive anti-aging and wrinkle-removing effects of the skin care products; in addition, the preparation method has the advantage of convenience for industrial production.
Description
Technical Field
The application relates to the field of skin care products, in particular to an anti-aging and wrinkle-removing composition, a preparation method and application thereof.
Background
Aging is a natural process and is a direct manifestation of the slowing of the body's function. However, with the continuous improvement of living standard of people, people pursue beauty more and more, and people hope to keep their face youthful forever by some external means, so that anti-aging products in the market are endless.
The outward manifestations due to skin aging are mainly: wrinkles form and gradually add and deepen; skin is loose, elasticity is reduced, and the like, so that various components which have the functions of removing wrinkles, moisturizing and improving skin firmness are generally added into skin care products in the prior art, so that the effects of removing wrinkles, improving skin firmness and the like of the anti-aging products are promoted.
Aiming at the related technologies, the inventor thinks that the expression forms of aging are various, if only one component with the wrinkle removing effect or only one component with the skin tightening effect is added, the anti-aging effect of the product is single easily, and the more comprehensive anti-aging is difficult to realize; however, if different ingredients with different efficacies are compounded for use, the mutual inhibition and even mutual offset effects may exist, so that the anti-aging product is difficult to realize a relatively comprehensive anti-aging effect, and therefore, the improvement space still exists.
Disclosure of Invention
In order to more comprehensively realize the anti-aging effect, the application provides an anti-aging and wrinkle-removing composition, a preparation method and application thereof.
In a first aspect, the present application provides an anti-aging and anti-wrinkle composition, which adopts the following technical scheme:
an anti-aging and wrinkle-removing composition, which is characterized in that: the paint comprises the following components in parts by mass:
30-40 parts of glycyrrhiza glabra extract;
50-65 parts of hydrolyzed soybean protein;
5-10 parts of ginseng fruit extract;
15-20 parts of a solvent.
By adopting the technical scheme, the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract are added to be matched with each other in a synergistic manner, so that the wrinkle removing effect of the anti-aging wrinkle removing composition is favorably improved, the skin tightening effect of the anti-aging wrinkle removing composition is favorably improved, the moisturizing effect is favorably realized, the skin is more elastic and firmer, and the anti-aging effect is favorably and comprehensively realized.
Preferably, the feed also comprises the following components in parts by mass:
10-15 parts of an accelerator.
By adopting the technical scheme, the accelerant is added, so that the synergistic effect of the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract is favorably promoted, the wrinkle removing effect, the skin tightening effect and the moisturizing effect of the anti-aging and wrinkle removing composition are better, and the anti-aging effect is favorably and comprehensively realized.
Preferably, the promoter comprises one or more of dog rose seed extract, oat griffith seed extract, melaleuca alternifolia extract, albizia flower extract and lonicera hypoglauca extract.
By adopting the technical scheme, one or more of dog tooth dog rose seed extract, brown swallow wheat seed extract, alternanthera leaf and thousand layer extract, albizia flower extract and lonicera hypoglauca extract are cooperatively matched with one another to promote the cooperative action of the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract, and the substances are all natural extracts, so that the skin is not easily stimulated, the skin-care liquid is suitable for sensitive skin, and the application range is wider.
Preferably, the accelerant comprises the following components in parts by mass:
8-10 parts of melaleuca alternifolia extract;
2-5 parts of lonicera hypoglauca miq extract.
By adopting the technical scheme, the melaleuca alternifolia extract and the lonicera hypoglauca miq extract in a specific proportion are mutually cooperated, so that the synergistic effect of the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract is favorably promoted, and simultaneously, the free radicals of the skin are favorably removed to a certain extent, the anti-aging and wrinkle-removing composition is easier to fundamentally solve the anti-aging problem, and the anti-aging effect of the anti-aging and wrinkle-removing composition is better.
Preferably, the feed also comprises the following components in parts by mass:
12-25 parts of a conditioner.
By adopting the technical scheme, the conditioner is added, so that the effect of the anti-aging and wrinkle-removing composition on removing free radicals of the skin is better improved, the problem of skin aging is better solved fundamentally, and the skin aging is slower.
Preferably, the conditioning agent comprises one or more of bioglycan-4, acetyl hexapeptide-8, kelp extract, sodium hyaluronate, collagen extract, oligopeptide-1, palmitoyl tetrapeptide-3, centella asiatica extract, and fullerene.
Preferably, the conditioner comprises the following components in parts by weight:
41-3 parts of biological sugar gum;
80.5-2 parts of acetyl hexapeptide;
3-6 parts of a kelp extract;
1-2 parts of sodium hyaluronate;
1-1.5 parts of collagen extract;
10.1-0.5 parts of oligopeptide;
30.4-1 parts of palmitoyl tetrapeptide;
4-7 parts of centella asiatica extract;
1-2 parts of fullerene.
By adopting the technical scheme, the substances are mutually cooperated and matched in a specific proportion, so that the effect of the anti-aging composition on removing free radicals of the skin is favorably and better improved, the aging problem of the skin is better and fundamentally solved, the aging of the skin is favorably and better delayed, and the anti-aging effect of the anti-aging and wrinkle-removing composition is better.
In a second aspect, the application provides a preparation method of an anti-aging and anti-wrinkle composition, which adopts the following technical scheme:
a method for preparing an anti-aging and wrinkle-removing composition comprises stirring and mixing the components of the anti-aging and wrinkle-removing composition uniformly to obtain the anti-aging and wrinkle-removing composition.
By adopting the technical scheme, the anti-aging and wrinkle-removing composition is obtained by directly and uniformly mixing and stirring the components of the anti-aging and wrinkle-removing composition, is simple and convenient to prepare, and is beneficial to industrial production of the anti-aging and wrinkle-removing composition.
In a third aspect, the present application provides an application of an anti-aging and anti-wrinkle composition, which adopts the following technical scheme:
the application of an anti-aging and wrinkle-removing composition is added into a skin care product.
By adopting the technical scheme, the anti-aging and wrinkle-removing composition is added into the skin care product, so that the anti-aging effect of the skin care product can be improved, and the operation is simple and convenient.
Preferably, the skin care product comprises skin care water, skin care milk, essence liquid, cream and facial mask.
By adopting the technical scheme, the anti-aging and anti-wrinkle composition is suitable for various skin care products such as water, milk, essence, cream and cream, and has a wide application range.
In summary, the present application has the following beneficial effects:
1. by adding the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract to be matched with each other in a synergistic manner, the wrinkle removing effect of the anti-aging wrinkle removing composition is favorably improved, the skin tightening effect of the anti-aging wrinkle removing composition is favorably improved, the moisturizing effect is favorably realized, the skin is more elastic and tighter, and the anti-aging effect is favorably and comprehensively realized.
2. One or more of rosa canina seed extract, grifola frondosa seed extract, melaleuca alternifolia extract, albizia flower extract and lonicera hypoglauca extract are cooperatively matched to promote the cooperative effect of the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract, and the above substances are all natural extracts, so that the skin irritation is not easily caused, the skin irritation-resistant tea is suitable for sensitive skin, and the application range is wider.
3. The synergistic cooperation of the melaleuca alternifolia extract and the lonicera hypoglauca extract in a specific ratio is beneficial to better promoting the synergistic effect of the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract and also beneficial to better clearing free radicals of skin to a certain extent, so that the anti-aging and wrinkle-removing composition is easier to fundamentally solve the anti-aging problem, and the anti-aging effect of the anti-aging and wrinkle-removing composition is better.
Detailed Description
The present application will be described in further detail with reference to examples.
In the following examples, Glycyrrhiza glabra extract is obtained from Glycyrrhiza glabra of Wuhan La Na pharmaceutical chemical Co., Ltd, product number 59870-68-7.
In the following examples, hydrolyzed soybean protein of 68607-88-5 available from Haiwatan biology Ltd of southeast Union was used.
In the following examples, the ginseng fruit extract was a ginseng fruit extract having QA-439 of Saishu Olympic Biotech Co.
In the following examples, hexanediol, available from Hubei Yuanmeng Biotech Co., Ltd, available under the trade name 6920-22-5, was used.
In the following examples, the extract of Albizzia julibrissin Durazz, having a product number QA-173 of Saishao Biotech Co., Ltd.
In the following examples, the extract of melaleuca alternifolia was obtained from melaleuca alternifolia of Hubei Xinbo chemical Co., Ltd., product No. 85085-48-9.
In the following examples, the extract of Lonicera hypoglauca was P0120719, a product of Beijing Lingbao technologies, Inc.
In the following examples, biosaccharide-4 from Kyoto Jiaqi Biotech Co., Ltd, Guangzhou was used.
In the following examples, acetyl hexapeptide-8 was acetyl hexapeptide-8 available from Shandonghai peptide Bio-pharmaceuticals, Inc., under the reference 616204-22-9.
In the following examples, the kelp extract was ysx # kelp extract from Gansu Probiotics Biotech limited.
In the following examples, sodium hyaluronate with a product number of 9067-32-7 from Chongqing Jiuzhou Biotech Co.
In the following examples, the collagen extract was P0121181, a product of Beijing Lingbao scientific Co.
In the following examples, oligopeptide-1 was oligopeptide-1 available from Olvo biomedical Co., Ltd, Hubei under the trade designation 72957-37-0.
In the following examples, palmitoyl tetrapeptide-3, product number 221227-05-0 of Shandong Han peptide Bio-medicine GmbH, was used.
In the following examples, the extract of centella asiatica is obtained from Shanxi Xin Maoyuan agriculture development Co., Ltd.
In the following examples, fullerene from Hesha Biotechnology, Inc., Guangzhou was used.
Examples 1 to 4
The embodiment of the application discloses an anti-aging and wrinkle-removing composition, which comprises the following components:
licorice extract, hydrolyzed soybean extract, ginseng fruit extract and solvent.
In the above examples, the solvent was hexylene glycol.
The addition amounts of the components of the anti-aging and wrinkle-removing composition of examples 1 to 4 are shown in table 1, and the unit of the amount of each component in table 1 is kg.
The embodiment of the application also discloses a preparation method of the anti-aging and anti-wrinkle composition, which comprises the following steps:
adding Glycyrrhiza glabra extract, hydrolyzed soybean extract, ginseng fruit extract and solvent into a stirring kettle, stirring at 150r/min, and stirring to obtain the anti-aging and wrinkle-removing composition.
TABLE 1
| Example 1 | Example 2 | Example 3 | Example 4 | |
| Glycyrrhiza glabra extract | 30 | 35 | 40 | 38 |
| Hydrolyzed soy protein | 65 | 50 | 57.5 | 60 |
| Ginseng fruit extract | 7.5 | 10 | 5 | 6 |
| Hexanediol | 17.5 | 20 | 15 | 16 |
Examples 5 to 13
The difference from example 4 is that: an accelerant is also added, and the accelerant, the glycyrrhiza glabra extract, the hydrolyzed soy protein, the ginseng fruit extract and the hexanediol are added into the stirring kettle together.
The composition and amount of the accelerator in examples 5-13 are shown in Table 2, and the amount of each component in Table 2 is in kg.
TABLE 2
Examples 14 to 17
The difference from example 4 is that: a conditioner is also added, and the conditioner, the glycyrrhiza glabra extract, the hydrolyzed soy protein, the ginseng fruit extract and the hexanediol are added into a stirring kettle together.
The compositions and amounts of the conditioning agents of examples 14-17 are shown in Table 3, and the amounts of the components in Table 3 are in kg.
TABLE 3
| Example 14 | Example 15 | Example 16 | Example 17 | |
| Biological sugar gum-4 | 12 | 25 | 1 | 3 |
| Acetyl hexapeptide-8 | 0 | 0 | 2 | 0.5 |
| Macrocystis extract | 0 | 0 | 3 | 6 |
| Hyaluronic acid sodium salt | 0 | 0 | 2 | 1 |
| Collagen extract | 0 | 0 | 1.5 | 1 |
| Oligopeptide-1 | 0 | 0 | 0.5 | 0.1 |
| Palmitoyl tetrapeptide-3 | 0 | 0 | 0.4 | 1 |
| Centella asiatica extract | 0 | 0 | 7 | 4 |
| Fullerene | 0 | 0 | 1 | 2 |
Examples 18 to 21
The difference from example 4 is that: and adding accelerator and conditioner, Glycyrrhiza glabra extract, hydrolyzed soybean protein, herba Herminii extract and hexanediol into a stirring kettle.
The components and the amounts added in examples 18 to 21 are shown in Table 4, and the unit of the amount of each component in Table 4 is kg.
TABLE 4
| Example 18 | Example 19 | Example 20 | Example 21 | |
| Glycyrrhiza glabra extract | 38 | 38 | 38 | 38 |
| Hydrolyzed soy protein | 60 | 60 | 60 | 60 |
| Ginseng fruit extract | 6 | 6 | 6 | 6 |
| Hexanediol | 16 | 16 | 16 | 16 |
| Melaleuca alternifolia extract | 8 | 9 | 10 | 9.5 |
| Lonicera hypoglauca extract | 5 | 2 | 3.5 | 4 |
| Biological sugar gum-4 | 2 | 3 | 1 | 1.5 |
| Acetyl hexapeptide-8 | 0.5 | 1.2 | 2 | 1 |
| Macrocystis extract | 6 | 3 | 4.5 | 5 |
| Hyaluronic acid sodium salt | 1.5 | 2 | 1 | 1.2 |
| Collagen extract | 1 | 1.25 | 1.5 | 1.1 |
| Oligopeptide-1 | 0.3 | 0.5 | 0.1 | 0.2 |
| Palmitoyl tetrapeptide-3 | 0.7 | 1 | 0.4 | 0.5 |
| Centella asiatica extract | 4 | 7 | 5.5 | 5 |
| Fullerene | 2 | 1 | 1.5 | 1.9 |
Comparative example 1
The difference from example 4 is that: equal amount of hexanediol was used instead of hydrolyzed soy protein and ginseng fruit extract.
Comparative example 2
The difference from example 4 is that: equal amount of hexanediol is used to replace Glycyrrhiza glabra extract and Herminium monorchis extract.
Comparative example 3
The difference from example 4 is that: equal amount of hexanediol was used in place of Glycyrrhiza glabra extract and hydrolyzed soy protein.
Comparative example 4
The difference from example 4 is that: equal amount of hexanediol was substituted for the Glycyrrhiza glabra extract.
Comparative example 5
The difference from example 4 is that: equal amount of hexylene glycol was substituted for the hydrolyzed soy protein.
Comparative example 6
The difference from example 4 is that: equal amount of hexanediol was substituted for the ginseng fruit extract.
Experimental examples 1 to 18
The application experimental example discloses an essence milk, and the essence milk comprises the following components by mass:
1kg of anti-aging and wrinkle-removing composition, 4kg of glycerin, 5kg of 1, 3-propylene glycol, 0.5kg of xanthan gum, 0.3kg of dipotassium glycyrrhizinate, 0.6kg of stearic acid, 0.6kg of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 5kg of glyceryl stearate, 0.1kg of p-hydroxyacetophenone and 82.9kg of water.
Of these, the anti-aging and anti-wrinkle compositions of examples 1 to 18 were prepared according to examples 1, 4, 5, 8, 10, 11, 12, 13, 14, 16, 18, 21 and comparative examples 1 to 6, respectively.
The preparation method of the essence milk comprises the following steps:
step (1), adding glycerol, 1, 3-propylene glycol, stearic acid, glycerol stearate, p-hydroxyacetophenone and water into a stirring kettle, stirring at a rotating speed of 60r/min for 25min, uniformly stirring, raising the temperature of the stirring kettle to 85 ℃, standing and preserving heat for 20min to obtain the essence milk premix.
And (2) naturally cooling to 50 ℃ in a stirring kettle, adding the anti-aging and wrinkle-removing composition into the essence milk premix, stirring at the rotating speed of 60r/min for 15min, uniformly stirring, adding acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and xanthan gum, and continuously stirring at the rotating speed of 60r/min for 15min to obtain the essence milk.
Experimental examples 19 to 36
The application experimental example discloses a skin lotion, which comprises the following components in parts by mass:
3kg of anti-aging and wrinkle-removing composition, 4kg of butanediol, 5kg of glycerin, 0.2kg of EDTA disodium, 0.05kg of caprylyl hydroximic acid, 0.05kg of p-hydroxyacetophenone, 0.2kg of triethanolamine, 2kg of xanthan gum and 85.5kg of water.
Of these, the anti-aging and anti-wrinkle compositions of experimental examples 19 to 36 were prepared according to examples 2, 4, 6, 9, 10, 11, 12, 13, 15, 17, 19, and 21 and comparative examples 1 to 6, respectively.
The preparation method of the skin lotion comprises the following steps:
adding butanediol, glycerol, EDTA disodium, p-hydroxyacetophenone and water into a stirring kettle, stirring at the rotating speed of 60r/min for 15min, uniformly stirring, raising the temperature of the stirring kettle to 80 ℃, standing and preserving heat for 20min to obtain the skin care water premix.
And (2) naturally cooling to 50 ℃ in the stirring kettle, adding caprylyl hydroximic acid, triethanolamine and the anti-aging and wrinkle-removing composition into the skin care lotion premix, stirring at the rotating speed of 60r/min for 15min, uniformly stirring, adding xanthan gum, and continuously stirring at the rotating speed of 60r/min for 10min to obtain the skin care lotion.
Experimental examples 37 to 54
The application experimental example discloses a face cream, which comprises the following components in parts by mass:
5kg of anti-aging and wrinkle-removing composition, 83.9kg of water, 4kg of glycerol, 0.5kg of sodium hyaluronate, 0.8kg of carbomer, 1kg of squalane, 2kg of polyglycerol-3-methyl glucose distearate, 0.1kg of allantoin, 0.2kg of EDTA disodium, 1kg of cetearyl alcohol, 0.5kg of hydrogenated lecithin and 1kg of p-hydroxyacetophenone.
The anti-aging compositions of experimental examples 37 to 54 were the anti-aging and wrinkle-removing compositions prepared in examples 3, 4, 7, 9, 10, 11, 12, 13, 15, 17, 20 and 21 and comparative examples 1 to 6, respectively.
The preparation method of the face cream comprises the following steps:
adding glycerol, squalane, polyglycerol-3 methyl glucose distearate, EDTA disodium, cetostearyl alcohol, hydrogenated lecithin, p-hydroxyacetophenone and water into a stirring kettle, stirring at the rotating speed of 60r/min for 25min, uniformly stirring, raising the temperature of the stirring kettle to 80 ℃, standing and preserving heat for 20min to obtain the cream premix.
And (2) naturally cooling to 50 ℃ in the stirring kettle, adding the anti-aging and anti-wrinkle composition into the cream premix, stirring at the rotating speed of 60r/min for 5min, adding sodium hyaluronate and carbomer after stirring uniformly, and continuing stirring at the rotating speed of 60r/min for 10min to obtain the cream.
Comparative example 1
The difference from experimental example 2 is that: equal amount of water is used to replace the anti-aging and wrinkle-removing composition.
Comparative example 2
The difference from the experimental example 20 is that: equal amount of water is used to replace the anti-aging and wrinkle-removing composition.
Comparative example 3
The difference from experimental example 38 is that: equal amount of water is used to replace the anti-aging and wrinkle-removing composition.
Experiment 1
Respectively taking 20mg of the essence milk, the skin care water and the face cream prepared in the experimental examples and the comparative examples, dissolving the essence milk, the skin care water and the face cream by using absolute ethyl alcohol, and fixing the volume to 250mL for later use; 20mg of 1, 1-diphenyl-2-trinitrophenylhydrazine (DPPH) is accurately weighed, dissolved by absolute ethyl alcohol and is added to a constant volume of 250mL for later use.
Placing 2mL of pre-prepared sample to be tested and 2mL of DPPH solution in a test tube, placing the test tube in a thermostat at 37 ℃ for 1h, taking absolute ethyl alcohol as a blank control, measuring the absorbance Ai of each sample to be tested at 517nm, calculating the clearance rate of free radicals, testing three groups of parallel samples for each sample to be tested, and calculating the average value.
The free radical clearance was calculated as: the radical clearance (%) [ (1- (Ai-Aj))/Ac ]. multidot.100%.
Wherein Ac is the absorbance of 2mL of absolute ethyl alcohol and 2mL of DPPH solution;
ai is the absorbance of 2mL of test agent plus 2mL of DPPH solution;
aj is the absorbance of 2mL of test agent plus 2mL of absolute ethanol solution.
Experiment 2
116 female volunteers of 20-50 years old are randomly selected, the volunteers are randomly divided into 58 groups of 2 persons in each group, the volunteers in each group are correspondingly coated on the cheeks by using the essence milk, the skin care water or the face cream prepared by the experimental example and the control example, the essence milk, the skin care water or the face cream are used for 2 times every day, 1 time is carried out in the morning and evening, 2mL is taken for each time, the application is kept for 30 days, the volunteers are subjected to the following detection after 30 days, and the average value of the detection data of the volunteers in each group is recorded.
Detection 1
Skin wrinkles of the volunteers before and after 30 days of use were detected using the rapid three-dimensional imaging system PRIMOS for skin (wherein the smaller the detected value, the fewer the skin wrinkles), and the growth rate (%) of the skin wrinkles was calculated and recorded. The growth rate of skin wrinkles was calculated as: the skin wrinkle growth rate (%) [ (skin wrinkle after use-skin wrinkle before use)/skin wrinkle before use ] × 100%.
Detection 2
The skin elasticity of the volunteers before and after 30 days of use was measured using a skin elasticity tester Corneometer MPA580 (wherein the greater the measured value, the better the skin elasticity), and the aging rate (%) of the skin elasticity was calculated and recorded. The aging rate of skin elasticity is calculated by: the aging rate (%) of skin elasticity [ (% after use-skin elasticity before use)/skin elasticity before use ] × 100%. Among them, the aging rate of skin elasticity is smaller as it approaches 0.
Detection 3
The skin firmness of the volunteers before and after 30 days of use was measured using a skin elastometer MPA580 (wherein the smaller the measured value, the more firm the skin), and the aging rate (%) of the skin firmness was calculated and recorded. The aging rate for skin firmness is calculated as: the aging rate (%) of skin firmness [ (% skin firmness after use-skin firmness before use)/skin firmness before use ]. 100%. Among them, the smaller the aging rate of skin firmness, the smaller the aging rate.
The data from the above experiments are shown in Table 5.
TABLE 5
According to the comparison of the data of the comparative example 1 and the experimental example 13 in table 5, the glycyrrhiza glabra extract is added into the experimental example 13 more than the comparative example 1, the radical clearance of the experimental example 13 is higher than that of the comparative example 1 to a certain extent, the skin wrinkle growth rate of the experimental example 13 is lower than that of the comparative example 1, and the skin elasticity and skin firmness aging rates of the experimental example 13 are similar to those of the comparative example 1, which shows that the addition of the glycyrrhiza glabra extract is beneficial to better improving the oxidation resistance of the anti-aging and wrinkle-removing composition to a certain extent, so that the oxidation resistance of the essence milk added with the anti-aging and-wrinkle-removing composition is better improved, the radical clearance is improved to a certain extent, the aging is better delayed, the skin wrinkles are less prone to grow, and the skin wrinkle growth rate is better reduced. Similarly, as can be seen from the comparison between the data of comparative example 2 and experimental example 31 and the data of comparative example 3 and experimental example 49 in table 5, the anti-aging and anti-wrinkle composition can achieve similar effects when being added to the skin softening lotion and the cream, and the anti-aging and anti-wrinkle composition can achieve the effect of improving the anti-aging and anti-wrinkle effects of the skin care products when being added to all the skin care products.
According to the comparison of the data of the comparative example 1 and the experimental example 14 in table 5, the hydrolyzed soy protein is newly added in the experimental example 14 compared with the comparative example 1, the aging rate of the skin elasticity and the skin firmness of the experimental example 14 are lower than those of the comparative example 1 to a certain extent, and the radical clearance rate and the skin wrinkle growth rate of the experimental example 14 are similar to those of the comparative example 1, which shows that the addition of the hydrolyzed soy protein is beneficial to better improving the moisturizing performance of the anti-aging and wrinkle-removing composition, so that the moisturizing performance of the essence milk added with the anti-aging and wrinkle-removing composition is better, and the addition of the hydrolyzed soy protein hardly plays a role in the radical clearance efficiency of the anti-aging and wrinkle-removing composition and the retardation of skin wrinkle growth. Similarly, as can be seen from the comparison between the data of comparative example 2 and experimental example 32 and the data of comparative example 3 and experimental example 50 in table 5, the anti-aging and anti-wrinkle composition added to the skin softening lotion and the cream can have similar effects, and the anti-aging and anti-wrinkle composition added to all skin care products can have the effect of improving the moisturizing effect of the skin care products.
As can be seen from comparison of the data of comparative example 1 and experimental example 15 in table 5, in experimental example 15, a ginseng fruit extract was newly added to comparative example 1, and the properties of experimental example 15 were similar to those of comparative example 1, indicating that the wrinkle-removing effect, moisturizing effect and radical-scavenging rate-improving effect of the anti-wrinkle composition hardly exerted by the addition of the ginseng fruit extract. Similarly, as shown by comparing the data of comparative example 2 with experimental example 33 and the data of comparative example 3 with experimental example 51 in table 5, the anti-aging and wrinkle-removing composition has similar effects when being added to the skin softening lotion and the cream, and the anti-aging and wrinkle-removing composition is added to all skin care products, and has little influence on the free radical scavenging performance, the wrinkle removing performance and the moisturizing performance of the skin care products.
According to comparison of data of comparative example 1, experimental example 14 and experimental example 16 in table 5, while example 16 is obtained by adding ginseng fruit extract more than example 14, the radical scavenging rate, the skin wrinkle growth rate, the skin elasticity aging rate and the skin firmness aging rate of example 16 are similar to those of example 14, which shows that the moisturizing effect of hydrolyzed soy protein is hardly affected by the synergistic combination of ginseng fruit extract and hydrolyzed soy protein. Similarly, as shown by the comparison of the data of comparative example 2 with experimental example 32, experimental example 34, and comparative example 3 with experimental example 50 and experimental example 52 in table 5, the anti-aging and wrinkle-removing composition has similar effects when added to skin-softening lotion and cream, and it is proved that the anti-aging and wrinkle-removing composition added with ginseng fruit extract and hydrolyzed soy protein cooperate with each other to hardly promote the action of the hydrolyzed soy protein, thereby hardly affecting the moisturizing performance of the skin care product.
According to comparison of data of comparative example 1, experimental example 13 and experimental example 17 in table 5, example 17 is newly added with ginseng fruit extract compared to example 13, and the radical scavenging rate, the skin wrinkle growth rate, the skin elasticity aging rate and the skin firmness aging rate of example 17 are similar to those of example 13, which shows that the addition of ginseng fruit extract and glycyrrhiza glabra extract in synergistic combination hardly affects the wrinkle removing effect and the radical scavenging effect of glycyrrhiza glabra extract. Similarly, as shown by comparing the data of comparative example 2 with those of experimental example 31, experimental example 35, comparative example 3, experimental example 49 and experimental example 53 in table 5, the anti-aging and wrinkle-removing composition has similar effects when added to skin softening lotion and cream, and it is proved that the addition of the ginseng fruit extract and the glycyrrhiza glabra extract to the anti-aging and wrinkle-removing composition has almost no promoting effect on the action of the glycyrrhiza glabra extract, and thus has almost no influence on the radical scavenging property, wrinkle removing property and moisturizing property of the skin care product.
According to the comparison of the data of comparative examples 1, 13, 14 and 18 in table 5, experimental example 13 added with glycyrrhiza glabra extract, experimental example 14 added with hydrolyzed soybean protein, experimental example 18 added with glycyrrhiza glabra extract and hydrolyzed soybean protein, compared with comparative example 1, the skin wrinkle growth rate of experimental example 18 is higher than that of experimental example 13 to some extent, and the skin elasticity aging rate and skin firmness aging rate of experimental example 18 are higher than that of experimental example 14 to some extent, which shows that the addition of glycyrrhiza glabra extract and hydrolyzed soybean protein to the anti-wrinkle composition can easily inhibit each other, thereby affecting the anti-aging effect and moisturizing effect of the anti-wrinkle composition. Similarly, as shown in table 5, comparing the data of comparative example 2, experimental example 31, experimental example 32, experimental example 36 and comparative example 3, experimental example 49, experimental example 50, and experimental example 54, the anti-aging and anti-wrinkle composition has similar effects when added to the skin-softening lotion and the cream, and it is proved that the anti-aging and anti-wrinkle composition is added with the glycyrrhiza glabra extract and the hydrolyzed soy protein to cooperate with each other, so that the anti-aging and anti-wrinkle composition is likely to affect the wrinkle-removing function and the moisturizing function of the skin care product to which the anti-aging and anti-wrinkle composition is added.
According to the comparison of the data of experimental example 2 and experimental examples 16-18 in table 5, the addition of the ginseng fruit extract, the glycyrrhiza glabra extract and the hydrolyzed soy protein in a synergistic manner is beneficial to relieving the mutual inhibition effect between the glycyrrhiza glabra extract and the hydrolyzed soy protein, and is also beneficial to better promoting the radical removal performance, the wrinkle removal performance and the moisture retention performance of the anti-aging and wrinkle-removing composition, and only when the ginseng fruit extract, the glycyrrhiza glabra extract and the hydrolyzed soy protein are in a synergistic manner, the anti-aging effect and the wrinkle removal effect of the anti-aging and wrinkle-removing composition can be improved, and any component is absent, so that the anti-aging effect and the wrinkle removal effect cannot be achieved. Similarly, as shown by comparison of data in experimental example 20 and experimental examples 34-36, and data in experimental example 38 and experimental examples 52-54 in table 5, the anti-aging and anti-wrinkle composition has similar effects when added to skin softening lotion and facial cream, and it is proved that the anti-aging and anti-wrinkle composition is beneficial to better improving the free radical scavenging performance, wrinkle removing performance and moisturizing performance of the anti-aging and anti-wrinkle composition by using the glycyrrhiza glabra extract, the hydrolyzed soybean protein and the ginseng fruit extract to cooperate with each other, and that the anti-aging and anti-wrinkle composition can improve the anti-aging and anti-wrinkle effects of skin care products when added to all skin care products.
As can be seen from the comparison of the data in the experimental examples 2-8 in Table 5, the accelerator in the experimental examples 2-8 has different compositions and different ratios of the amounts, while the radical scavenging rate of experimental example 3 is significantly higher than that of experimental example 2 and experimental examples 4-8, and the wrinkle-removing effect and moisturizing effect of experimental example 3 are superior to those of experimental example 2 and experimental examples 4-8, which shows that the moisturizing effect and wrinkle-removing effect of the anti-aging wrinkle-removing composition can be better promoted only by adopting the synergistic cooperation of the cajeput extract and the lonicera hypoglauca extract in a specific ratio, and the effect of improving the effect of removing free radicals of the anti-aging and wrinkle-removing composition can be achieved only by adopting the synergistic cooperation of the cajeput extract and the lonicera hypoglauca miq extract in a specific ratio, and the effect of improving the effect of removing free radicals of the anti-aging and wrinkle-removing composition cannot be achieved due to the lack of any component. Similarly, the data comparison between the experimental examples 20-26 and the experimental examples 38-44 in table 5 shows that the anti-aging and anti-wrinkle composition has similar effects when being added to the skin softening lotion and the cream, which proves that the anti-aging and anti-wrinkle composition can achieve similar effects when being added to all skin care products, and is beneficial to better improving the anti-aging and anti-wrinkle effects of the skin care products.
According to the comparison of the data of the experimental example 2 and the experimental examples 9-10 in the table 5, the experimental examples 9-10 are added with the conditioner more than the experimental example 2, the composition and the dosage ratio of the conditioner in the experimental examples 9-10 are different, and the radical scavenging rate of the experimental example 10 is higher than that of the experimental example 9 and that of the experimental example 2, which shows that the conditioner is formed by adding the conditioner and matching the biosaccharide gum-4, the acetyl hexapeptide-8, the macroalgae extract, the sodium hyaluronate, the collagen extract, the oligopeptide-1, the palmitoyl tetrapeptide-3, the centella asiatica extract and the fullerene together in a specific ratio, so that the effect of scavenging radicals of the anti-aging and wrinkle-removing composition is improved better, and the anti-aging effect of the skin is solved better and fundamentally. Similarly, as shown by comparing the data of experimental example 20 and experimental examples 27-28 and the data of experimental example 38 and experimental examples 45-46 in table 5, the anti-aging and anti-wrinkle composition has similar effects when being added to the skin softening lotion and the cream, and the anti-aging and anti-wrinkle composition is proved to have similar effects when being added to all skin care products, and is beneficial to better improving the anti-aging and anti-wrinkle effects of the skin care products.
According to the comparison of the data of the experimental example 2 and the experimental examples 11-12 in the table 5, the accelerator and the conditioner are added into the experimental examples 11-12 more than the experimental example 2, the radical removal rate of the experimental examples 11-12 is much higher than that of the experimental example 2, and the wrinkle removing effect and the moisturizing effect of the experimental examples 11-12 are better than those of the experimental example 2, which shows that the addition of the accelerator and the conditioner is beneficial to better improving the radical removal performance, the wrinkle removing performance and the moisturizing performance of the anti-aging and wrinkle-removing composition, so that the anti-aging and wrinkle-removing performance of the anti-aging and wrinkle-removing composition is better. Similarly, as shown by comparing the data of experimental example 20 and experimental examples 39-30 and the data of experimental example 38 and experimental examples 47-48 in table 5, the anti-aging and anti-wrinkle composition has similar effects when being added to the skin softening lotion and the cream, and the anti-aging and anti-wrinkle composition is proved to have similar effects when being added to all skin care products, and is beneficial to better improving the anti-aging and anti-wrinkle effects of the skin care products.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.
Claims (10)
1. An anti-aging and wrinkle-removing composition, which is characterized in that: the paint comprises the following components in parts by mass:
30-40 parts of glycyrrhiza glabra extract;
50-65 parts of hydrolyzed soybean protein;
5-10 parts of ginseng fruit extract;
15-20 parts of a solvent.
2. The anti-aging and wrinkle-removing composition according to claim 1, wherein: the paint also comprises the following components in parts by mass:
10-15 parts of an accelerator.
3. The anti-aging and wrinkle-removing composition according to claim 2, wherein: the promoter comprises one or more of dog tooth rose seed extract, brown Fugu oat seed extract, folium Melaleucae Latifoliae extract, flos Albizziae extract, and Lonicera hypoglauca extract.
4. The anti-aging and wrinkle-removing composition according to claim 2, wherein: the accelerant comprises the following components in parts by mass:
8-10 parts of melaleuca alternifolia extract;
2-5 parts of lonicera hypoglauca miq extract.
5. The anti-aging and wrinkle-removing composition according to any one of claims 1 to 4, wherein: the paint also comprises the following components in parts by mass:
12-25 parts of a conditioner.
6. The anti-aging and wrinkle-removing composition according to claim 5, wherein: the conditioner comprises one or more of bioglycasin-4, acetyl hexapeptide-8, a giant kelp extract, sodium hyaluronate, a collagen extract, oligopeptide-1, palmitoyl tetrapeptide-3, a centella asiatica extract and fullerene.
7. The anti-aging and wrinkle-removing composition according to claim 5, wherein: the conditioner comprises the following components in parts by mass:
41-3 parts of biological sugar gum;
80.5-2 parts of acetyl hexapeptide;
3-6 parts of a kelp extract;
1-2 parts of sodium hyaluronate;
1-1.5 parts of collagen extract;
10.1-0.5 parts of oligopeptide;
30.4-1 parts of palmitoyl tetrapeptide;
4-7 parts of centella asiatica extract;
1-2 parts of fullerene.
8. A method of preparing an anti-aging and wrinkle-removing composition as defined in any one of claims 1 to 7, wherein: and (3) uniformly stirring and mixing the components of the anti-aging and wrinkle-removing composition to obtain the anti-aging and wrinkle-removing composition.
9. Use of an anti-aging and wrinkle-removing composition according to any one of claims 1 to 7, characterized in that: the anti-aging and wrinkle-removing composition is added into a skin care product.
10. Use of an anti-aging and wrinkle-removing composition according to claim 9, characterized in that: the skin care product comprises skin care water, skin care milk, essence liquid, cream and facial mask.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010968429.5A CN111991297A (en) | 2020-09-15 | 2020-09-15 | Anti-aging wrinkle-removing composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010968429.5A CN111991297A (en) | 2020-09-15 | 2020-09-15 | Anti-aging wrinkle-removing composition and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111991297A true CN111991297A (en) | 2020-11-27 |
Family
ID=73469292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010968429.5A Pending CN111991297A (en) | 2020-09-15 | 2020-09-15 | Anti-aging wrinkle-removing composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111991297A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104830531A (en) * | 2015-04-29 | 2015-08-12 | 绥阳县吉帮金银花科技发展有限公司 | Wild honeysuckle flower essential oil and preparation method thereof |
| US20170042790A1 (en) * | 2015-08-14 | 2017-02-16 | Johnson & Johnson Consumer Inc. | Methods of reducing signs of skin aging using compositions comprising ampelopsis grossedentata and albizia julibrissin extracts |
| CN108671163A (en) * | 2018-07-27 | 2018-10-19 | 广东成烨泰生物科技有限公司 | Herbal mixture bactericidal composition and its application in washing shield product |
| CN110787082A (en) * | 2019-09-29 | 2020-02-14 | 广州达达眼健康管理有限公司 | Eye cell repair composition and eye care product containing same |
| CN110840807A (en) * | 2019-12-14 | 2020-02-28 | 广州尚妆优品生物科技有限公司 | Wrinkle-removing composition |
-
2020
- 2020-09-15 CN CN202010968429.5A patent/CN111991297A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104830531A (en) * | 2015-04-29 | 2015-08-12 | 绥阳县吉帮金银花科技发展有限公司 | Wild honeysuckle flower essential oil and preparation method thereof |
| US20170042790A1 (en) * | 2015-08-14 | 2017-02-16 | Johnson & Johnson Consumer Inc. | Methods of reducing signs of skin aging using compositions comprising ampelopsis grossedentata and albizia julibrissin extracts |
| CN108671163A (en) * | 2018-07-27 | 2018-10-19 | 广东成烨泰生物科技有限公司 | Herbal mixture bactericidal composition and its application in washing shield product |
| CN110787082A (en) * | 2019-09-29 | 2020-02-14 | 广州达达眼健康管理有限公司 | Eye cell repair composition and eye care product containing same |
| CN110840807A (en) * | 2019-12-14 | 2020-02-28 | 广州尚妆优品生物科技有限公司 | Wrinkle-removing composition |
Non-Patent Citations (5)
| Title |
|---|
| 中山市奥丰化妆品有限公司: "《奥丰富勒烯焕肤精华液》", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20200709180500E3DVG&NID=20200709180500E3DVG》 * |
| 佘守军: "《红腺忍冬研究概况》", 《海峡药学》 * |
| 张卫明: "《一带一路经济植物》", 30 November 2017, 东南大学出版社 * |
| 田硕: "《合欢花现代研究分析》", 《中医学报》 * |
| 袁素华: "《紫艳人参果的栽培要点》", 《福建农业》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110279638A (en) | A kind of reparation skin skin care compositions and preparation method thereof | |
| CN108143702A (en) | A kind of efficient whitening and moisturizing facial mask liquid, facial mask and preparation method thereof | |
| KR101319990B1 (en) | Cosmetic composition comprising an asparagus cochinchinensis and maca complex-fermented extract | |
| KR101427572B1 (en) | Skin external composition for promoting the production of hyaluronic acid containing ginsenoside Re and ginsenoside compound Ｋ | |
| CN109350579B (en) | Whitening cosmetic additive, whitening skin-refreshing lotion and preparation method thereof | |
| CN103976906A (en) | Plant extract mixture having moisturizing and inflammation-diminishing effects | |
| CN112206308A (en) | Nourishing and bacteriostatic gel and preparation method thereof | |
| CN111568800A (en) | Tightening anti-aging cosmetic containing oligopeptide | |
| KR20150100288A (en) | Cosmetic composition comprising the extract of crude drug fermentation using the black yeast | |
| CN113171318A (en) | Freeze-dried powder preparation with moisturizing, whitening, relieving and repairing functions and preparation method thereof | |
| CN114224779A (en) | Eye repair composition and application thereof | |
| CN114522129A (en) | Moisturizing, firming and repairing composition, cosmetic and preparation method | |
| CN105232439A (en) | Moisturizing skin care product and preparation method thereof | |
| CN108125810A (en) | A kind of compound moisturizing remediation composition and its preparation method and application | |
| CN108653137B (en) | Composition and application thereof in preparation of beauty cosmetics | |
| KR101814498B1 (en) | Cosmetic Composition Containing the Mixed Extract of Eucalyptus Globulus Leaf and Trifolium Pratense Leaf | |
| CN109498543A (en) | The composition of adjustable skin microecological balance and its application and comprising its milky lotion and milky lotion preparation method | |
| CN107802545A (en) | A kind of anti-oxidant and lightening compositions and the skin care item containing said composition | |
| KR20110052095A (en) | Cosmetic composition for moisturizing of skin containing tremella fuciformis extracts | |
| KR20150081892A (en) | Cosmetic composition comprising the extract of Helianthus Tuberosus Root | |
| CN110974775A (en) | Allergy-relieving composition containing nostoc sphaeroides and preparation method and application thereof | |
| CN111991297A (en) | Anti-aging wrinkle-removing composition and preparation method and application thereof | |
| CN116035987A (en) | Small molecule peptide multielement composition and skin care product containing same | |
| CN105640836B (en) | A kind of surfactant and preparation method thereof containing lotus active constituent | |
| CN111184667B (en) | Composition with moistening and moisture-keeping and anti-allergy effects and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201127 |