Classifications

• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
  • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
  • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
  • C08G63/08—Lactones or lactides
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
  • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
  • B29C64/10—Processes of additive manufacturing
  • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
  • B29C64/124—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B33—ADDITIVE MANUFACTURING TECHNOLOGY
  • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
  • B33Y10/00—Processes of additive manufacturing
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B33—ADDITIVE MANUFACTURING TECHNOLOGY
  • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
  • B33Y70/00—Materials specially adapted for additive manufacturing
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
  • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
  • C08F283/01—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to unsaturated polyesters
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
  • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
  • C08F283/02—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polycarbonates or saturated polyesters
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
  • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
  • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
  • C08G63/91—Polymers modified by chemical after-treatment
  • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
  • C08G75/02—Polythioethers
  • C08G75/04—Polythioethers from mercapto compounds or metallic derivatives thereof
  • C08G75/045—Polythioethers from mercapto compounds or metallic derivatives thereof from mercapto compounds and unsaturated compounds
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
  • B29K2033/00—Use of polymers of unsaturated acids or derivatives thereof as moulding material
  • B29K2033/04—Polymers of esters
  • B29K2033/12—Polymers of methacrylic acid esters, e.g. PMMA, i.e. polymethylmethacrylate
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
  • B29K2067/00—Use of polyesters or derivatives thereof, as moulding material
  • B29K2067/04—Polyesters derived from hydroxycarboxylic acids
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
  • B29K2081/00—Use of polymers having sulfur, with or without nitrogen, oxygen or carbon only, in the main chain, as moulding material
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
  • B29K2096/00—Use of specified macromolecular materials not provided for in a single one of main groups B29K2001/00 - B29K2095/00, as moulding material
  • B29K2096/02—Graft polymers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
  • B29K2096/00—Use of specified macromolecular materials not provided for in a single one of main groups B29K2001/00 - B29K2095/00, as moulding material
  • B29K2096/04—Block polymers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
  • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
  • B29K2105/0002—Condition, form or state of moulded material or of the material to be shaped monomers or prepolymers

Definitions

• the present invention relates generally to compounds and compositions useful in a photocuring process such as stereolithography (SLA) wherein a macromer is
• Stereolithography is a relatively well developed additive printing technique for preparing three-dimensional (3-D) objects.
• light such as ultraviolet (UV) or visible light
• UV ultraviolet
• visible light is used to photopolymerize liquid material into designed structures, such as three-dimensional articles, with high accuracy and precision.
• Thin successive layers are photocrosslinked by UV or visible light, for example, under the direction of a sliced CAD (computer aided design) model.
• SLA generally uses a liquid photocrosslinkable polymeric composition that may be referred to as a resin or an ink formulation.
• a resin or an ink formulation The macroscopic properties and degradation profiles of articles produced by SLA depend in part on the polymer chemistry and the processing techniques.
• the present disclosure provides compounds and compositions useful in a photocuring process such as stereolithography (SLA), wherein a macromer is
• photopolymerized to form for example, a solid surface or a manufactured article.
• the present disclosure provides compounds and compositions useful in a photocuring process.
• the photocuring process is useful in manufacturing articles, such as medical devices and coatings.
• An exemplary photocuring process is stereolithography (SLA), which is an additive manufacturing process wherein a macromer is photopolymerized to form a manufactured articles.
• SLA stereolithography
• Another exemplary photocuring process is a coating process whereby a compound and/or composition of the present disclosure is placed on a surface and then cured with actinic radiation (i.e., photopolymerized or photocured) to provide a solid coating on the surface.
• actinic radiation i.e., photopolymerized or photocured
• These photopolymerized / photocured products may generally be referred to herein as articles, coatings, films, materials and the like.
• a coating or other material can likewise be prepared.
• the articles, coatings etc. are biodegradable.
• the present disclosure provides biodegradable polymeric materials.
• the materials may be used to produce articles that have a limited lifetime, such that after some period of time, the article formed from the biodegradable material is no longer present.
• the material may be a coating on a device, such as a medical device, where the coating degrades after some period of time.
• the material may be a used to prepare a medical device, for example, a mesh for tissue repair, so that after a time, some or none of the article is present and tissue repair is accomplished.
• stereolithography may be used to prepare such materials and articles, using, e.g., compounds and compositions as disclosed herein.
• the present disclosure addresses concerns about photopolymerized materials, such as SLA-produced articles, that come into contact with living entities, include concerns regarding the safety and efficacy of the produced articles, particularly their biocompatibility and cytotoxicity.
• the present disclosure provides a method for photopolymerization printing an article comprising, a) exposing for a time with light, a photopolymerizable composition comprising at least one photopolymerizable macromer component as disclosed herein; optionally in combination with one or more other components such as at least one photoinitiator component and/or at least one light reflective material component comprising a light reflective material suspended in the composition; and forming a printed article comprising a polymerization product of the photopolymerizable macromer component(s) (i.e., the polymerized macromers).
• the present disclosure provides a method for photopolymerization coating of an article comprising, a) applying a photopolymerizable compounds and/or composition of the present disclosure to a surface, b) exposing for a time with light, the photopolymerizable compounds and/or composition comprising at least one photopolymerizable macromer component as disclosed herein; optionally in combination with one or more other components such as at least one photoinitiator component and/or at least one light reflective material component comprising a light reflective material suspended in the composition; and forming a solid coating comprising a polymerization product of the photopolymerizable macromer component(s) (i.e., the polymerized macromers).
• the present disclosure provides the polymerization product of a macromer (which may also be referred to as a prepolymer) where the macromer has been polymerized by, e.g., one or more methods disclosed herein.
• the present disclosure provides an article, which may be referred to as a polymeric article, produced from a photopolymerizable compound or composition as disclosed herein, optionally by one or more methods as disclosed herein.
• the photopolymerized macromer or article may be a nontoxic article.
• the article may com prise biodegradable photopolymerized macromer, optionally in admixture with a nontoxic amount of photoinitiator.
• the polymeric article is biodegradable, in whole or in part, under physiological conditions. However, in an alternative aspect, the polymeric article is not biodegradable under physiological conditions.
• a photopolymerizable composition comprising at least one photopolymerizable macromer component as described herein; optionally in combination with one or more other components such as a diluent, a photoinitiator, a colorant, and/or a light reflective material component.
• a stereolithography photopolymerizable composition comprising at least one photopolymerizable macromer component optionally in combination with one or more other components such as a diluent, a photoinitiator, a colorant, and/or a light reflective material component.
• the present disclosure further provides a continuous liquid interface production photopolymerizable composition, comprising at least one photopolymerizable macromer component as disclosed herein, optionally in combination with one or more other components such as a diluent, a photoinitiator, a colorant, and/or a light reflective material component.
• the present disclosure additionally provides a photopolymerizable ink composition, comprising, at least one photopolymerizable macromer component as disclosed herein.
• the ink composition may optionally also contain one or more other components such as a diluent, a photoinitiator, a colorant, and/or a light reflective material component.
• a photopolymerizable compound also referred to herein as a macromer, comprising a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a light-reactive functional group (Q) and (A) is the polymerization product of monomers selected from trimethylene carbonate (also referred to herein as T, or as TMC) and e-caprolactone (also referred to herein as caprolactone, or C, or CAP), while (B) is the polymerization product of monomers selected from glycolide, lactide and p-dioxanone.
• the macromer may be a photopolymerizable macromer component in compositions and methods as disclosed herein, and may be photopolymerized to provide articles.
• the present disclosure provides a composition
• a composition comprising a plurality of compounds, each compound of the plurality comprising a bifunctional central core and either 1 or 2 arms extending from the central core, each arm terminating in a hydroxyl group.
• the hydroxyl group may also be referred to as the end group.
• the central core is a bifunctional core, where at least one of those two functional groups, and as many as both of those functional groups of the central core have reacted with monomers to form arms.
• These compounds may be used to form photopolymerizable macromers useful in, e.g., the methods and compositions disclosed herein.
• the present disclosure also provides a composition
• a composition comprising a plurality of compounds, each compound of the plurality comprising a trifunctional central core and either 1 or 2 or 3 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a trifunctional core, where at least one of those three functional groups, and as many as all three of those functional groups of the central core have reacted with monomers to form arms.
• These com pounds may be used to form photopolymerizable macromers useful in, e.g., the methods and compositions disclosed herein.
• the present disclosure additionally provides a composition
• a composition comprising a plurality of compounds, each compound of the plurality comprising a tetrafunctional central core and either 1 or 2 or 3 or 4 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a tetrafunctional core, where at least one of those four functional groups, and as many as all four of those functional groups of the central core have reacted with monomers to form arms.
• These compounds may be used to form photopolymerizable macromers useful in, e.g., the methods and compositions disclosed herein.
• any of the compositions of the present disclosure may contain an effective amount of a photoinitiator, i.e., an amount of photoinitiator which is effective to achieve polymerization of the photopolymerizable compound when the composition is exposed to radiation emitted from a non-natural light source that delivers light of a selected wavelength suitable to activate the photoinitiator.
• a photoinitiator i.e., an amount of photoinitiator which is effective to achieve polymerization of the photopolymerizable compound when the composition is exposed to radiation emitted from a non-natural light source that delivers light of a selected wavelength suitable to activate the photoinitiator.
• the present disclosure provides a method of 3D-printing, also known as additive printing, e.g., stereolithography, which comprises providing a
• polymerizable composition as disclosed herein having a photopolymerizable compound and a photoinitiator, heating that composition to a molten state, depositing that molten state composition into a desired shape, and exposing that desired shape to light which is effective to activate the photoinitiator, in order to photopolymerize the photopolymerizable compound in the polymerizable composition.
• FIG. 1A, FIG. IB, FIG. 1C and FIG. ID show proton NMR spectra of triaxial BCPE polymers (BCPE 4, BCPE 6, BCPE 9 and BCPE 11, respectively), where the peaks for the protons of the methacrylate groups are marked: upfield TMC/caprolactone-associated (arrows) and downfield glycolide-associated (asterisks) methacrylate terminal alkenyl protons.
• FIG. 2A, FIG. 2B, FIG. 2C and FIG. 2D show proton NMR spectra of linear BCPE polymers (BCPE 5, BCPE 7 , BCPE 10 and BCPE 12, respectively), where the peaks for the protons of the methacrylate groups: upfield TMC/caprolactone-associated (arrows) and downfield glycolide-associated (asterisks) methacrylate terminal alkenyl protons.
• FIG. 3 shows percent change in strength over time for BCPE 4 - BCPE 7 photopolymerized polymer films of the present disclosure.
• FIG. 4 shows percent water content over time for BCPE 4 - BCPE 7
• FIG. 5 shows percent mass loss over time of BCPE 4 - BCPE 7 photopolymerized polymer films of the present disclosure.
• FIG. 6 shows effect of glycolide concentration on percent mass loss of photopolymerized polymer films of the present disclosure.
• FIG. 7 is a graph showing an increase in dynamic viscosity and an increase in molecular weight of a thiolated polymer of the present disclosure after being exposed to increasing photocurable conditions.
• the present disclosure provides compounds and compositions which are useful in additive printing, particularly additive printing techniques such as stereolithography (SLA) wherein a macromer is photopolymerized to form a manufactured article.
• Representative compounds comprise a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a light-reactive functional group (Q) and (A) is the free- radical polymerization product from monomers selected from trimethylene carbonate (T) and e-caprolactone (C), while (B) is the free-radical polymerization product from monomers selected from glycolide, lactide and p-dioxanone.
• SLA stereolithography
• the present disclosure provides a photopolymerizable composition.
• the composition will comprise one or more photopolymerizable compounds, also referred to herein as a macromer or a photopolymerizable macromer or a photopolymerizable macromer component.
• the photopolymerizable compound is monofunctional in that there is one mole of photoreactive group per mole of compound.
• the photopolymerizable compound is polyfunctional, e.g., difunctional, trifunctional, tetrafunctional, and/or pentafunctional. Higher functional materials with 6-18 reactive sites (i.e., Q groups, as described herein) are additionally contemplated in the present disclosure.
• the composition may comprise a relatively low molecular weight species and/or a relatively high molecular weight species.
• a macromer may comprise reactive groups including photopolymerizable groups, sometimes referred to herein as photoreactive or photocurable groups.
• the photoreactive group is an allyl or vinyl-based reactive group, such as the unsaturated functionality of acrylate (including methacrylates), or other allyl and vinyl-based reactive groups.
• the photoreactive group is a thiol (-SH) group.
• the macromer will typically have a molecular weight of less than 250,000 Da, or less than 200,000 Da, or less than 150,000 Da, or less than 100,000 Da, or less than 50,000 Da, or less than 25,000 Da, or less than 20,000 Da, or less than 15,000 Da, or less than 10,000 Da, or less than 9,000 Da, or less than 8,000 Da, or less than 7,000 Da, or less tha n 6,000 Da, or less than 5,000 Da.
• the present disclosure provides a compound comprising a central core and a plurality, e.g., 2-4, arms extending from the central core, each arm ending (i.e., terminating) in a hydroxyl group.
• the compound may be represented by the formula CC-[arm] n where CC represents the central core and n is selected from a number within the ranges of 2-18, or 2-14, or 2-8, or 2-6, or 2-4.
• Each arm is formed by the polymerization of monomers selected from two groups, the two groups being denoted as group A and group B.
• CC-[arm] n may be written as either CC-[(A)p-(B)q-OH] n, or CC-[(B)q-(A)p-OH] n where each of (A)p-(B)q and (B)q-(A)p represents an arm.
• the terminal functional group of the arm may be shown, where an exemplary terminal functional group is hydroxyl.
• A represents the polymerization product of one or more monomers comprising, and optionally selected only from, trimethylene carbonate (T or TMC) and caprolactone (C or CAP), and p represents the number of monomers that have been polymerized to form the polymerization product A, where p is selected from 1-40, or 1-30, or 1-20, or 1-10.
• B represents the polymerization product of one or more monomers comprising, and optionally selected only from, glycolide (G or GLY), lactide (L or LAC) and p-dioxanone (D or DOX), and q represents the number of monomers that have been polymerized to form the polymerization product B, where q is selected from 1-40, or 1-30, or 1-20, or 1-10.
• each arm would have a chemical formula selected from I M G, TTCG, TCTG, TCCG, CCCG, CCTG, CTCG, and CTTG.
• This exemplary compound of the present disclosure may be written as CC-[arm] 3 where each arm is independently selected from TTTG-OH, TTCG-OH, TCTG-OH, TCCG-OH, CCCG-OH, CCTG-OH, CTCG-OH, and CTTG-OH, or alternatively as either CC-[(T,T,C)-(G)-OH] 3 or CC-[(T,T,C) 3 -(G)I- OH] 3 .
• the present disclosure also provides compositions comprising a plurality of compounds, each described by CC-[arm] n .
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a central core and each compound having 2 arms extending from the central core, where each arm terminates in a hydroxyl group, so that each compound may be represented by the formula CC-[arm]2.
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a central core and each compound having 3 arms extending from the central core, where each arm terminates in a hydroxyl group, so that each compound may be represented by the formula CC-[arm]3.
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a central core and each compound having 4 arms extending from the central core, where each arm terminates in a hydroxyl group, so that each compound may be represented by the formula CC-[arm] 4 .
• each compound of the plurality will have the same number of arms, and each will have the same ordering of A and B groups selected from CC-[(A)-(B)]n and CC-[(B)-(A)]n.
• the present disclosure provides (a) a composition comprising a plurality of compounds of formula CC-[(A)-(B)]2; (b) a composition comprising a plurality of compounds of formula CC-[(A)-(B)]3; (c) a composition comprising a plurality of compounds of formula CC-[(A)-(B)] 4 ; (d) a composition comprising a plurality of compounds of formula CC-[(B)-(A)]2; (e) a composition comprising a plurality of compounds of formula CC-[(B)-(A)]3; and (f) a composition comprising a plurality of compounds of formula CC-[(B)-(A)] 4 .
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a bifunctional central core and either 1 or 2 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a bifunctional core, where at least one of those two functional groups, and as many as both of those functional groups of the central core have reacted with monomers to form arms.
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a trifunctional central core and either 1 or 2 or 3 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a trifunctional core, where at least one of those three functional groups, and as many as all three of those functional groups of the central core have reacted with monomers to form arms.
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a tetrafunctional central core and either 1 or 2 or 3 or 4 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a tetrafunctional core, where at least one of those four functional groups, and as many as all four of those functional groups of the central core have reacted with monomers to form arms.
• each arm in the plurality of compounds may be represented by the formula (A)- (B).
• each arm in the plurality of compounds may be represented by the formula (B)-(A).
• the composition is prepared by reacting the central core with monomers of Group A followed by reacting that reaction product with monomer(s) selected from Group B, then the compounds in the composition will have the formula CC-[(A)-(B)].
• the composition is prepared by reacting the central core with monomers of Group B followed by reacting that reaction product with monomer(s) selected from Group A, then the compounds in the composition will have the formula CC-[(B)-(A)].
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a bifunctional central core and either 1 or 2 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a bifunctional core, where at least one of those two functional groups, and as many as both of those functional groups of the central core have reacted with monomers to form arms, so the compounds may generally be represented by one or more of CC-[(A)-(B)]i and CC-[(A)-(B)] 2 where CC is a difunctional core.
• the compounds of the composition may generally be represented by one or more of CC-[(B)-(A)]i and CC-[(B)-(A)] 2 where CC is a difunctional core.
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a trifunctional central core and either 1 or 2 or 3 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a trifunctional core, where at least one of those three functional groups, and as many as all three of those functional groups of the central core have reacted with monomers to form arms, so the compounds may generally be represented by one or more of CC-[(A)-(B)]i and CC-[(A)-(B)] 2 and CC-[(A)-(B)]3 where CC is a trifunctional core.
• the compounds of the composition may generally be represented by one or more of CC-[(B)-(A)]i and CC-[(B)-(A)] 2 and CC-[(B)-(A)] 3 where CC is a trifunctional core.
• the present disclosure provides a composition comprising a plurality of compounds, each compound of the plurality comprising a tetrafunctional central core and either 1 or 2 or 3 or 4 arms extending from the central core, each arm terminating in a hydroxyl group.
• the central core is a tetrafunctional core, where at least one of those four functional groups, and as many as all four of those functional groups of the central core have reacted with monomers to form arms, so the compounds may generally be represented by one or more of CC-[(A)-(B)]i and CC-[(A)-(B)] 2 and CC-[(A)-(B)] 3 and CC-[(A)-(B)] 4 where CC is a tetrafunctional core.
• the compounds of the composition may generally be represented by one or more of CC-[(B)-(A)]i and CC-[(B)-(A)] 2 and CC-[(B)-(A)] 3 and CC-[(B)-(A)] 4 where CC is a tetrafunctional core.
• the present disclosure provides multi-arm compounds as described herein, wherein an arm terminates in a Q group, and that Q group is
• exemplary Q groups may contain a thiol group which is photopolymerizable.
• exemplary Q groups may contain a carbon-carbon double bond which is photopolymerizable, e.g., the Q group may comprise vinyl group such as present in an acrylate or methyacrylate group, each having a
• photopolymerizable component e.g., a photopolymerizable thiol or carbon-carbon double bond
• a photopolymerizable component may be introduced into a multi-arm compound as described herein by reaction of the terminal hydroxyl group with a suitable reagent.
• Methods to convert a hydroxyl group to thiol-containing group or a carbon-carbon double bond containing group are generally known and may be utilized to prepare compounds of the present disclosure, where examples are provided herein.
• the Q group will contain a photoreactive group, and in particular a photoreactive group that allows for polymerization of the Q-containing macromer, the Q group may also contain additional atoms which influence the
• photoreactivity of the photoreactive group e.g., a carbonyl group adjacent to the carbon- carbon double bond as illustrated herein, and/or which were used to introduce the photoreactive group to the macromer, e.g., a succinate ester may be used to introduce a thiol group, as illustrated herein.
• the multi-arm compound having a terminal hydroxyl group may be reacted with a reactive acrylate or methacrylate compound, such as methacrylic anhydride, acrylic anhydride, methacryloyl chloride, or acryloyl chloride.
• a reactive acrylate or methacrylate compound such as methacrylic anhydride, acrylic anhydride, methacryloyl chloride, or acryloyl chloride.
• a multi-arm compound having a terminal hydroxyl group as disclosed herein may undergo an esterification reaction.
• One method for esterification is to add stoichiometric amounts of macromer and a mercapto carboxyl acid compound in the presence of a carbodiimide (e.g., N,N'-dicyclohexylcarbodiimide) and a catalyst (e.g., dimethylaminopyridine).
• a carbodiimide e.g., N,N'-dicyclohexylcarbodiimide
• a catalyst e.g., dimethylaminopyridine
• Exemplary mercapto carboxyl acids include, but are not limited to, the following compounds: 3-mercaptopropionic acid, thiolactic acid, thioglycolic acid, mercaptobutyric acid, mercaptohexanoic acid, mercaptobenzoic acid, mercaptoundecanoic acid, mercaptooctanoic acid, and n-acetyl cysteine.
• Another exemplary method of forming thiol functionalized macromer is to first modify the hydroxyl terminated macromer to form terminal carboxylic acid groups.
• One example of this is to react the hydroxyl terminated macromer with a succinic anhydride.
• the macromer can be reacted with mercapto alcohols by an esterification reaction or with mercapto amines to form amide bonds.
• mercapto alcohols include, but are not limited to, the following: mercapto propanol, mercaptohexanol, mercaptooctanol, and mercapto undecanol.
• mercapto amines include, but are not limited to, the following: cysteine, glutathione, 6- amino-l-hexanethiol hydrochloride, 8-amino-l-octanethiol hydrochloride, and 16-amino-l- hexadecanethiol hydrochloride.
• Yet another method for forming thiol functionalized macromer is to react the macromer having terminal hydroxyl groups with a lactone monomer having pendant thiol groups. This would occur in a third step ring opening polymerization.
• the present disclosure provides compositions that contain photopolymerizable compounds as identified above, optionally in combination with one or more additional components.
• the photopolymerizable compounds as identified above have a central core and one or more arms with Q end groups.
• the macromers present in a composition all contain the same central core.
• all of the macromer components of a composition are prepared from trimethylolpropane or pentaerythritol.
• a composition of the present disclosure contains a mixture of macromer components, for example, some of the macromer components are triaxial, made from, e.g., trimethylolpropane, and other macromer components of the same composition are tetraaxial, made from, e.g., pentaerythritol.
• compositions comprising a plurality of compounds as identified above, where each compound of the plurality incorporates the same identity (although not the same number) of monomers used to form the A and B groups.
• the members of the plurality will differ from one another in the number of monomer units that are present in an arms, and more specifically in the number of polymerized monomer units present in the A groups and/or the number of polymerized monomer units present in the B groups.
• the A groups will be formed from monomers selected from trimethylene carbonate (T) and caprolactone (C), although the number of T-derived units and the number of C-derived units in an arm may be different among the arms of a compound, and between the arms of different compounds within the plurality of compounds present in the composition.
• the B groups will be formed from monomers selected from glycolide (G), lactide (L) and p-dioxanone (D), although the number of G-derived units and the number of L-derived units and the number of D-derived units in an arm may be different among the arms of a compound, and between the arms of different compounds within the plurality of compounds present in the composition.
• composition comprises a plurality of compounds each represented by formula CC-[arm] n and each arm is written as (A)-(B) rather than (B)-(A), then the composition comprises a plurality of compounds each having the formula CC-[(A)- ( B)] 2.
• the members of the plurality will differ in the number of monomer units used to form the A and B groups.
• each compound of the plurality is represented by the formula CC-[(A)p-(B)q]2
• the sum of p and q may be 2 (in which case each of p and q is 1), or the sum may be 3 (in which case one of p and q is 1 and the other of p and q is 2), or the sum may be 4 (in which case either each of p and q is 2, or else one of p and q is 1 and the other of p and q is 3).
• compounds of the formula CC-[arm] n when compounds of the formula CC-[arm] n are formed from a trifunctional central core, and A is added to CC prior to the addition of B, then compounds of the formula CC-[arm] n may be written as CC-[(A)p-(B)q-OH]3. If, in this example, A is formed by the polymerization of two Ts and one C, then p would be three and A would be selected from I I I , TTC, TCT, TCC, CCC, CCT, CTC, and CTT, independently within each arm. If, continuing with this example, B is formed by the polymerization of one G, then q would be one and B would be G.
• each arm would have a chemical formula selected from I M G, TTCG, TCTG, TCCG, CCCG, CCTG, CTCG, and CTTG.
• This exemplary compound of the present disclosure may be written as CC-[arm] 3 where each arm is independently selected from TTTG-OH, TTCG-OH, TCTG-OH, TCCG-OH, CCCG-OH, CCTG-OH, CTCG-OH, and CTTG-OH, or alternatively as either CC-[(T,T,C)-(G)-OH] 3 or CC-[(T,T,C) 3 -(G)I- OH] 3 .
• each arm is formed by the polymerization of monomers selected from two groups, the two groups being denoted as group A and group B.
• CC-[arm] n may be written as either CC-[(A)p-(B)q-OH] n , or CC-[(B)q-(A)p] n where each of (A)p-(B)q and (B)q- (A)p represents an arm.
• A represents the polymerization product of one or more monomers comprising, and optionally selected only from, trimethylene carbonate (T) and caprolactone (C), and p represents the number of monomers that have been polymerized to form the polymerization product A, a nd is selected from 1-40, or 1-30, or 1- 20, or 1-10.
• B represents the polymerization product of one or more monomers comprising, and optionally selected from, glycolide (G), lactide (L) and p- dioxanone (D), and q represents the number of monomers that have been polymerized to form the polymerization product B, and is selected from 1-40, or 1-30, or 1-20, or 1-10.
• the compounds of the present disclosure having hydroxyl end groups are useful in the preparation of the corresponding photopolymerizable compounds, and compositions containing such photopolymerizable compounds.
• the hydroxyl end group may be converted to a photopolymerizable group by techniques known in the art and illustrated herein.
• These photopolymerizable groups are referred to herein by the short-hand notation "Q".
• the present disclosure provides a compound comprising a central core and a plurality, e.g., 2-4, arms extending from the central core, each arm terminating in a photopolymerizable group (Q).
• the compound may be represented by the formula CC-[arm-Q] n where CC represents the central core and n is selected from a number within the ranges of 2-18, or 2-14, or 2-8, or 2-6, or 2-4.
• Each arm is formed by the polymerization of monomers selected from two groups, the two groups being denoted as group A and group B.
• CC- [arm]n may be written as either CC-[(A)p-(B)q-Q]n, or CC-[(B)q-(A)p-Q] n where each of (A)p-
• (B)q and (B)q-(A)p represents an arm.
• the terminal functional group of the arm may be shown, where Q generally represents a photoreactive terminal functional group.
• A represents the polymerization product of one or more monomers comprising, and optional ly selected only from, trimethylene carbonate (T) and caprolactone
• p represents the number of monomers that have been polymerized to form the polymerization product A, where p is selected from 1-40, or 1-30, or 1-20, or 1-10.
• B represents the polymerization product of one or more monomers comprising, and optionally selected only from, glycolide (G), lactide (L) and p-dioxanone (D), and q represents the number of monomers that have been polymerized to form the
• polymerization product B where q is selected from 1-40, or 1-30, or 1-20, or 1-10.
• the present disclosure provides a photopolymerizable compound, and compositions containing such compounds, wherein the compound is described by one of: the compound is or comprises a structure CC-[A-B-Q] n and n is 2; the compound is or comprises a structure CC-[A-B-Q] n and n is 3; the compound is or comprises a structure CC-[A-B-Q]n and n is 4; the compound is or comprises a structure CC-[B-A-Q]n and n is 2; the compound is or comprises a structure CC-[B-A-Q] n and n is 3; the compound is or comprises a structure CC-[B-A-Q] n and n is 4.
• the compound has four arms, a molecular mass of less than 40,000 g/mol, or less than 20,000 g/mol, and is a solid at room temperature.
• the compound has three arms, a molecular mass of less than 15,000 g/mol, and is a liquid at room temperature.
• the compound has two arms, a molecular mass of less than 5,000 g/mol, and is a liquid at room temperature.
• the photopolymerizable compounds of the present disclosure have relatively short arms, e.g., 1-10 monomer residues/arm.
• a monomer residue refers to the polymerization product of the monomer, i.e., the structure that the monomer has after that monomer has been incorporated into a polymer and is thus providing a monomer residue in that polymer.
• those compounds should be in a fluid state: either the compounds themselves are fluid or the compounds are dissolved in a solvent and/or diluent to provide a fluid composition.
• the compounds themselves may be fluid at the application temperature of the additive printing process, where the application temperature may be above room temperature such that the compound must be heated to achieve a molten state, or they may be dissolved in a solvent at a relatively high concentration and still provide a low viscosity solution.
• the compounds and compositions of the present disclosure containing such compounds can be described by one or more of the following features which characterize the A region (also referred to as a block) of the compound: have a block A which comprises residues formed from trimethylene carbonate (TMC or T), i.e., which are the polymerization product or residue of TMC; have a block A which comprises residues formed from caprolactone (CAP or C); have a block A which comprises residues formed from both TMC and CAP; at least 90% of the residues in block A are residues formed from TMC or CAP; the compound comprises 1-45, or 2-45 residues formed from TMC; the compound comprises 1-15 or 2-15 residues formed from TMC; the compound comprises 1-10 or 2-10 residues formed from TMC; region A has a molecular weight of from 102-2500 g/mol; region A has a molecular weight of 102-1000 g/mol; region A has a molecular weight of 102-900 g/mol;
• TMC trimethylene carbonate
• each B block comprise 1-45 or 2-45 monomer residues; each B block comprise 1-15 or 2-15 monomer residues; each B block comprises 1-10 or 2-10 monomer residues.
• the compounds may also, or alternatively, be described by one or more of the following: the compound has a molecular mass of less than 40,000 g/mol; the compound has a molecular mass of less than 25,000 g/mol; the compound has a molecular mass of less than 10,000 g/mol.
• the photopolymerizable compositions of the present disclosure may optionally be described by having a viscosity at room temperature of less than 50,000 cP; or having a viscosity at room temperature of less than 30,000 cP; or having a viscosity at room temperature of less than 20,000 cP.
• the compositions may contain a diluent.
• the diluent may be reactive or non reactive.
• a reactive diluent undergoes a photopolymerization reaction when exposed to light (UV or visible light) while a non-reactive diluent is inert to such light exposure.
• An exemplary reactive diluent is PEG-diacrylate (PEG-DA or PEGDA).
• a photopolymerizable compound comprising a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a light-reactive functional group (Q), (A) is the ring opening polymerization product from monomers selected from trimethylene carbonate (T) and e-caprolactone (C),and (B) is the ring-opening polymerization product from monomers selected from glycolide, lactide and p-dioxanone.
• a light-curable composition comprising one or more photopolymerizable compounds of embodiment 1, optionally also containing a photoinitiator.
• a light-reactive polyaxial macromer compound comprising a central core (CC) and 2- 4 arms extending from the central core, where at least one of the arms comprises a light-reactive functional group (Q) and a block copolymer comprising blocks A and B; wherein
• block A comprises residues formed from at least one of, i.e., one or both of, trimethylene carbonate (TMC) and e-caprolactone (CAP); and b. block B comprises residues formed from at least one of, i.e., one, two or all three of, glycolide, lactide and p-dioxanone.
• a light-reactive composition comprising one or more macromer compounds of embodiment 3.
• the photopolymerizable compounds as described herein having photopolymerizable Q groups, and the compositions of the present disclosure that include such compounds, will undergo polymerization upon sufficient exposure to light of appropriate wavelength, optionally in the presence of a photoinitiator, and further optionally in the presence of other components.
• the choice of appropriate wavelength, time of exposure, and curing agent identity and amount, is selected in view of identity and quantity of the Q group in the compounds and compositions, as is conventional in the art.
• Photopolymerization is sometimes referred to radiation curing, in which case the photoinitiator may be referred to as the curing agent.
• a photoinitiator refers to an organic (carbon-containing) molecule that creates reactive species when exposed to radiation.
• the photoinitiator creates a radical reactive species, as opposed to, e.g., a cationic or anionic reactive species.
• Photoinitiators are well known components for the preparation of photopolymers which find use in photo-curable coatings, adhesives and dental restoratives.
• photopolymerizable compositions disclosed herein comprise at least one photoinitiator that absorbs a wavelength of light in a range between about 10 nm to about 770 nm, or between about 100 nm to about 770 nm, or between about 200 nm to about 770 nm, and all wavelengths thereinbetween the stated range.
• a photoinitiator component comprises a photoinitiator that absorbs a wavelength of light of greater than or equal to 300 nm, up to about 770 nm.
• a photoinitiator component comprises a photoinitiator that absorbs a wavelength of light of greater than or equal to 365 nm, up to about 770 nm. In an aspect, a photoinitiator component comprises a photoinitiator that absorbs a wavelength of light of greater than or equal to 375 nm, up to about 770 nm. In an aspect, a photoinitiator component comprises a photoinitiator that absorbs a wavelength of light of greater than or equal to 400 nm, up to about 770 nm. The choice of wavelength will depend on the identity of the photoinitiator. Suppliers of commercially available photoinitiators indicate the appropriate wavelength for that particular photoinitiator.
• Free radical generating photoinitiators may be used to achieve polymer curing according to the present disclosure. These photoinitiators may be used to cure thiol- containing polymers as well as double bond-containing polymers such as polymer that contain acrylate and/or methacrylate functionality. There are two types of free-radical generating photoinitiators, designated as Type I and Type II photoinitiators, which may be used according to the present disclosure.
• Type I photoinitiators are unimolecular free-radical generators; that is upon the absorption of UV-visible light a specific bond within the initiator's structure undergoes homolytic cleavage to produce free radicals. Homolytic cleavage is a bonding pair of electron's even scission into to free radical products. Examples of homolytic cleavage in several common classes of Type I photoinitiators: benzoin ethers, benzyl ketals, a-dialkoxy- aceto-phenones, a-hydroxy-alkyl-phenones, and acyl phosphine oxides.
• Type I photoinitiators available from, for example, BASF, BASF SE, Ludwigshafen, Germany, include, but are not limited to, IrgacureTM 369, IrgacureTM 379, IrgacureTM 907, DarocurTM 1173, I rgacureTM 184, IrgacureTM2959, DarocurTM 4265, IrgacureTM 2022, IrgacureTM 500, I rgacureTM 819, IrgacureTM 819-DW, IrgacureTM 2100, LucirinTM TPO, LucirinTM TPO-L, IrgacureTM 651, DarocurTM BP, IrgacureTM 250, I rgacureTM 270, IrgacureTM 290, IrgacureTM 784, DarocurTM MBF, hand IrgacureTM 754, lithium phenyl-2, 4,6
• Type II photoinitiators require a co-initiator, usual ly an alcohol or amine, functional groups that can readily have hydrogens abstracted, in addition to the photoinitiator.
• the absorption of UV-visible light by a Type-ll photoinitiator causes an excited electron state in the photoinitiator that will abstract a hydrogen from the co initiator, and in the process, splitting a bonding pair of electrons.
• Benzophenone, thio- xanthones, and benzophenone-type photoinitiators are the most common Type II photoinitiators. Further examples of some common Type II photoinitiators include riboflavin, Eosin Y, and camphorquinone.
• a photoinitiator component in a composition of the present disclosure comprises a Type I photoinitiator.
• a photoinitiator component in a composition of the present disclosure comprise a Type II photoinitiator.
• a combination of a Type I and a Type II photoinitiator is present in photopolymerization composition of the present disclosure.
• Q may be a carbon-carbon double bond, e.g., a vinyl group.
• exemplary vinyl groups are an acrylate group and a methacrylate group.
• the compound a nd composition undergoes photopolymerization when exposed to UV radiation.
• Q may be a thiol group.
• the photopolymerizable compound having one or more Q groups undergoes photopolymerization when exposed to light having a wavelength of 300-450 nm, or 300-425 nm, or 350-450 nm, or 350-425 nm, or 365-405 nm, as examples.
• the compound and composition undergoes photopolymerization when exposed to UV radiation.
• thiol free radical polymerizations using a photoinitiator require a much higher concentration of photoinitiator than is needed when the Q group has a photopolymerizaable carbon-carbon double bond.
• the photoinitiator can initiate the thiol groups but two thiol groups can only polymerize when two thiyl radicals meet. Additionally, the joining of two thiyl radicals is a termination of the radical groups which is why a high concentration of photoinitiator is required.
• photopolymerizable group is or comprises a carbon-carbon double bond, e.g., a vinyl group
• one free radical can initiate and propagate a large number of vinyl groups before termination.
• the single arm compound provides less than 20 wt% of the total weight of compounds having Q groups. In other embodiments, the single arm compound provides less than 15 wt%, or less than 10 wt%, or less than 5 wt%, or less than 4 wt%, or less than 3 wt%, or less than 2 wt% of the total weight of compounds having Q groups.
• the central core may be derived from any of a bifunctional central core (bifunctional initiator), or a trifunctional central core (a
• trifunctional initiator or a tetrafunctional central core (a tetrafunctional initiator).
• any of the photopolymerizable compositions as described herein there may be some amount of compound(s) selected from those comprising the formula CC-Q, CC-A-Q, and CC-B-Q.
• a compound comprising the formula CC-Q will have a central core directly bonded to a photopolymerizable group Q.
• a compound comprising the formula CC-A-Q will have an arm formed from monomer residues from Group A but not from Group B, and this arm will terminate in a Q group and be attached to a central core CC.
• a compound comprising the formula CC-B-Q will have an arm formed from monomer residues from Group B but not from Group A, and this arm will terminate in a Q group and be attached to a central core CC.
• the central core may be derived from any of a bifunctional central core (bifunctional initiator), or a trifunctional central core (a bifunctional central core (bifunctional initiator), or a trifunctional central core (a bifunctional central core (bifunctional initiator), or a trifunctional central core (a
• trifunctional initiator or a tetrafunctional central core (a tetrafunctional initiator).
• any of the photopolymerizable compositions as described herein there may be some amount of one or more compounds wherein some of the arms terminate in a Q end group but other of the arms terminate in a hydroxyl end group. Such compounds may result when there is incomplete conversion of the hydroxyl end groups to the corresponding reactive Q groups.
• Exemplary compounds of this type may be described by the formula ⁇ [(B)q-(A)p]n- ⁇ m-CC- ⁇ [(A)p-(B)q-Q] ⁇ r, which denotes compounds wherein "m” of the arms terminate with hydroxyl end groups and "r" of the arms terminate in Q end groups, where the total of m and r is the functionality of the central core (CC).
• m may be 1 and r may be 1, when the central core is bifunctional.
• m may be 1 and r may be 2 when the central core is trifunctional.
• may be 2 and r may be 1 when the central core is trifunctional.
• the corresponding situation may occur with compounds of the formula ⁇ [(A)q-(B)p]n- ⁇ m-CC- ⁇ [(B)p-(A)q-Q] ⁇ r.
• a colorant such as a dye
• the addition of a dye can achieve the purpose of tailoring a formulation to a desired color.
• dyes for non toxic and biocompatible formulations are typically used at concentrations of 2 wt. % or less (for example, see PCT/US2016/059910, which is incorporated herein for its teaching of polymerizable compositions and use of dyes).
• concentrations of 2 wt. % or less for example, see PCT/US2016/059910, which is incorporated herein for its teaching of polymerizable compositions and use of dyes.
• most dyes have been regulated by the FDA to contain 0.1-0.3 wt% as shown in the D&C Violet additive for most absorbable suture products.
• the combination of high dye concentrations and high photoinitiator concentrations provide much of the pronounced toxicity of 3-D
• the present disclosure provides a stereolithography (SLA) ink composition.
• the composition includes a photopolymerizable compound as disclosed herein, also referred to as a photopolymerizable macromer.
• the ink composition includes at least one photoinitiator component, typically in a total concentration of less than 2 wt%, or less than 1.5 wt%, or less than 1 wt%, or less than 0.9 wt%, or less than 0.8 wt%, or less than 0.7 wt%, or less than 0.6 wt%, or less than 0.5 wt%, or less than 0.25 wt%, or less than 0.1 wt% based on the total weight of polymerizable macromer.
• the SLA ink composition contains at least one light reflective material component comprising a light reflective material suspended in the composition, where the light reflective material component modulates the light dose of the composition when compared to the light dose of the composition without the light reflective material.
• Suitable light reflective materials for this and other embodiments disclosed here are disclosed in U.S. Provisional Patent Application Serial No. 62/653584, entitled Methods and Compositions for Photopolymerizable Additive Manufacturing, filed April 6, 2018 by Applicant Poly-Med, Inc., having inventors M.A. Vaughn and P. Saini.
• an additive may be a dye.
• a printed article made with an SLA ink of the present disclosure may be colored due to the presence of a dye, or may have any desired attribute such as having at least a portion of the article that is, but is not limited to, fluorescent, radioactive, reflective, flexible, stiff, pliable, breakable, or a combination thereof.
• Photopolymerizable compositions disclosed herein are made by combining the desired components, typically with stirring to achieve a homogeneous composition.
• the desired components may be mixed using a homogenizer.
• a homogenizer for example, a thermoplastic resin, a thermoplastic resin, or a mixture thereof.
• photopolymerizable composition disclosed herein may be prepared by combining ingredients such as those identified above, including a photopolymerizable macromer and a photoinitiator.
• the desired components may include a dispersion agent to aid in suspension.
• the listed components may optionally be heated prior to mixing.
• the listed components may optionally be placed under vacuum to remove gas bubbles.
• Methods disclosed herein comprise methods for using photopolymerizable compositions to make articles, particularly non-toxic and biodegradable articles.
• a composition disclosed herein may be used as photopolymerizable or photocurable ink or resin in 3-D printing methods.
• a composition disclosed herein may be used as photopolymerizable or photocurable ink or resin in 3-D printing method of stereolithography (SLA).
• SLA stereolithography
• the present disclosure provides a method for SLA printing an article which comprises exposing for a time with light, a photopolymerizable composition comprising at least one photopolymerizable macromer compound as disclosed herein; and at least one photoinitiator component, typically in a total concentration of less than 1.0 wt%.
• a photopolymerizable composition comprising at least one photopolymerizable macromer compound as disclosed herein; and at least one photoinitiator component, typically in a total concentration of less than 1.0 wt%.
• the photopolymerizable compositions disclosed herein may be used in the method for SLA printing an article.
• the photopolymerizable composition may comprise a reactive diluent or a nonreactive diluent.
• a reactive diluent is a diluent that participates in the polymerization reaction, for example, the reactive diluent is polymerized with, for example, a macromer.
• a method for printing an article by SLA may comprise a secondary curing step comprising curing the printed article.
• a secondary curing step involves exposing at least a portion of the printed article so that at least a portion of the printed article undergoes a second polymerization reaction.
• a portion of an article may be exposed to the same or different wavelength radiation as was used in the first polymerization step, and photoinitiators, which may be the same or different photoinitiators as those reacting in the first polymerization step, may be activated to cause previously unpolymerized or partially polymerized reactive groups to undergo
• a secondary curing step may change properties of the printed article.
• the printed article after the initial printing step, is soft and pliable throughout. After exposing the exterior of the printed article to a secondary curing step, using a different wavelength radiation, the exterior of the printed article is hard and not pliable.
• a method for printing an article by SLA according to the present disclosure may comprise pre- and/or post-treatments of a printed article.
• the printed article may be rinsed after printing, before a secondary curing step, after a secondary printing step or before or after each of these steps.
• a printed article is the article resulting after a SLA 3-D printing period is completed.
• the printed article may be a structure or a portion of a structure.
• the printed article may be in the form of a film, such as a coating that is printed onto a surface.
• printing is used to mean contacting a polymeric composition with a surface and causing the polymeric composition to further polymerize.
• Printing may involve contacting a polymeric composition with a surface that is then exposed to UV and/or visible light so that the polymeric composition undergoes further polymerization.
• the surface that the polymeric composition contacts may be any surface including a polymerized layer of the polymeric composition.
• a printed article may or may not contain residual amounts of components of a photopolymerizable composition.
• a printed article may comprise diluent or photopolymerized diluent, or photoinitiator.
• additives may include thixotropic materials, colorants, tracer materials or conductive materials.
• an additive may be a dye.
• a printed article may be colored due to the presence of a dye, or may have any desired attribute such as having at least a portion of the article that is, but is not limited to, fluorescent, radioactive, reflective, flexible, stiff, pliable, breakable, or a combination thereof.
• a method of SLA printing an article may comprise a photopolymerizable composition comprising monomers or macromers that are capable of undergoing polymerization, such as monomers or macromers that have functional groups capable of undergoing photopolymerization reactions to form oligomers and/or polymers.
• macromers and monomers may comprise ethylenically unsaturated aliphatic or aromatic reactive groups or end groups. Disclosed macromers and monomers are functional in the disclosed methods herein.
• Methods for SLA printing an article comprise photopolymerizing
• photopolymerizable compositions at light wavelength from about 10 nm to about 770 nm.
• UV radiation has a wavelength of from about 10-400 nm
• visible radiation has a wavelength of 390-770 nm.
• photopolymerizable compositions comprising a light reflective material component photopolymerizes in a shorter exposure time than a photopolymerizable composition without the light reflective material component under the same polymerization conditions.
• a method of printing an article using SLA in a device for printing by SLA comprises photopolymerizable compositions comprising a photoinitiator component.
• a photoinitiator component may comprise one or more photoinitiators, and may also comprise other materials, for example, a diluent, excipient, inhibitors, or other solutions.
• a photoinitiator component may be in a concentration of from about 0.05 wt% to about 5.0 wt% of the photopolymerizable composition.
• a photoinitiator component may be in a concentration of less than 0.50 wt% of the photopolymerizable composition.
• a photoinitiator component may be 0.25 wt% of the
• a photoinitiator component may be less than 0.25 wt% of the photopolymerizable composition. In an aspect, a photoinitiator component may be 0.10 wt% of the photopolymerizable composition. In an aspect, a photoinitiator component may be less than 0.10 wt% of the photopolymerizable composition.
• a method of printing an article using SLA in a device for printing by SLA comprises photopolymerizable compositions comprising at least one photoinitiator that absorbs at a wavelength of light from about 10 nm to about 770 nm.
• a photoinitiator absorbs at a wavelength of light of greater than or equal to 300 nm.
• a photoinitiator absorbs at a wavelength of light of than or equal to 365 nm.
• a photoinitiator absorbs at a wavelength of light of greater than or equal to 375 nm.
• a photoinitiator absorbs at a wavelength of light of greater than or equal to 400 nm.
• a method of printing an article using SLA in a device for printing by SLA comprises photopolymerizable compositions comprising at least one photoinitiator component that comprises a photoinitiator that is a Type I, Type I I, a cationic photoinitiator or a combination thereof.
• a method of printing an article using SLA in a device for printing by SLA comprises photopolymerizing or curing a photopolymerizable composition at a depth of less than 150 microns.
• a method disclosed herein comprises photopolymerizing or curing a photopolymerizable composition at a depth of from about 5 microns to about 50 microns, and all depths thereinbetween.
• a method of printing an article using SLA in a device for printing by SLA comprises photopolymerizable compositions comprising a light reflective material component comprising a light reflective material that is absorbable in physiological conditions.
• a light reflective material component comprises a light reflective material that is biocompatible for biological organisms.
• a light reflective material component comprises a light reflective material that polymerizes with at least one of a photopolymerizable macromer, a diluent, a light reflective material, or a combination thereof.
• the present disclosure comprises a polymeric article formed upon
• compositions disclosed herein are compositions disclosed herein.
• an article made by the methods disclosed herein from the compositions disclosed herein.
• an article may be a medical device.
• an article may be a portion of a medical device.
• an article may be porous.
• an article may be biodegradable under physiological conditions.
• a biodegradable article may have a degradation time of about three days to about five years.
• an article may not be biodegradable. I n an aspect, a portion of an article may be biodegradable and a second portion may be nonbiodegradable or have a different degradation time from the degradation time of the first portion or the rest of the article.
• the article may be drug-eluting, for example, all or a portion of an article may elute a bioactive agent that was comprised in the photopolymerizable composition.
• bioactive agents include, but are not limited to, fibrosis-inducing agents, antifungal agents, antibacterial agents and antibiotics, anti-inflammatory agents, anti scarring agents, immunosuppressive agents, immunostimulatory agents, antiseptics, anesthetics, antioxidants, cell/tissue growth promoting factors, anti-neoplastic, anticancer agents and agents that support ECM integration.
• fibrosis-inducing agents include, but are not limited to talcum powder, metallic beryllium and oxides thereof, copper, silk, silica, crystalline silicates, talc, quartz dust, and ethanol; a component of extracellular matrix selected from fibronectin, collagen, fibrin, or fibrinogen; a polymer selected from the group consisting of polylysine, poly(ethylene-co-vinylacetate), chitosan, N-carboxybutylchitosan, and RGD proteins; vinyl chloride or a polymer of vinyl chloride; an adhesive selected from the group consisting of cyanoacrylates and crosslinked poly(ethylene glycol)-methylated collagen; an inflammatory cytokine (e.g., T6Eb, PDGF, VEGF, bFGF, TNFa, NGF, GM-CSF, IGF-a, IL-1, IL-Ib, IL-8, IL-6, and growth hormone); connective tissue growth factor (
• the device may additionally comprise a proliferative agent that stimulates cellular proliferation.
• proliferative agents include: dexamethasone, isotretinoin (13-cis retinoic acid), 17 ⁇ -estradiol, estradiol, la, 25- dihydroxyvitamin D 3 , diethylstibesterol, cyclosporine A, L-NAME, all-trans retinoic acid (ATRA), and analogues and derivatives thereof (see US 2006/0240063, which is
• antifungal agents include, but are not limited to, polyene antifungals, azole antifungal drugs, and Echinocandins.
• antibacterial agents and antibiotics include, but are not limited to, erythromycin, penicillins, cephalosporins, doxycycline, gentamicin, vancomycin, tobramycin, clindamycin, and mitomycin.
• anti-inflammatory agents include, but are not limited to, non- steriodal anti-inflammatory drugs such as ketorolac, naproxen, diclofenac sodium and fluribiprofen.
• anti-scarring agents include, but are not limited to cell-cycle inhibitors such as a taxane, immunomodulatory agents such as serolimus or biolimus (see, e.g., paras. 64 to 363, as well as all of US 2005/0149158, which is incorporated by reference in its entirety).
• immunosuppressive agents include, but are not limited to, glucocorticoids, alkylating agents, antimetabolites, and drugs acting on immunophilins such as ciclosporin and tacrolimus.
• immunostimulatory agents include, but are not limited to, interleukins, interferon, cytokines, toll-like receptor (TLR) agonists, cytokine receptor agonist, CD40 agonist, Fc receptor agonist, CpG-containing immunostimulatory nucleic acid, complement receptor agonist, or an adjuvant.
• antiseptics include, but are not limited to, chlorhexidine and tibezonium iodide.
• anesthetic include, but are not limited to, lidocaine, mepivacaine, pyrrocaine, bupivacaine, prilocalne, and etidocaine.
• antioxidants include, but are not limited to, antioxidant vitamins, carotenoids, and flavonoids.
• cell growth promoting factors include, but are not limited to, epidermal growth factors, human platelet derived TGF-b, endothelial cell growth factors, thymocyte-activating factors, platelet derived growth factors, fibroblast growth factor, fibronectin or laminin.
• antineoplastic/anti-cancer agents include, but are not limited to, paclitaxel, carboplatin, miconazole, leflunamide, and ciprofloxacin.
• agents that support ECM integration include, but are not limited to, gentamicin
• the articles of the present disclosure may contain a mixture of bioactive agents in order to obtain a desired effect.
• an antibacterial and an anti inflammatory agent may be combined in a single article to provide combined effectiveness.
• a method for photopolymerization printing an article comprising,
• a photopolymerizable composition comprising
• the photopolymerizable macromer component comprises a central core (CC) and a plurality of arms extending from the central core, where all or substantially all of the arms terminate in a photopolymerizable group (Q); where each arm is formed by the polymerization of monomers selected from two groups, denoted as group A and group B; to provide region A and region B, respectively, in the arms, where region A represents the polymerization product of one or more monomers comprising, and optionally selected only from, trimethylene carbonate (T) and caprolactone (C), and region B represents the polymerization product of one or more monomers comprising, and optionally selected only from, glycolide (G), lactide (L) and p-dioxanone (D).
• CC central core
• Q photopolymerizable group
• each arm is formed by the polymerization of monomers selected from two groups, denoted as group A and group B; to provide region A and region B, respectively, in the arms, where region A represents the polymerization product
• the photopolymerizable composition comprises a first photopolymerizable macromer component that is biaxial and a second photopolymerizable macromer component that is polyaxial but not biaxial, e.g., is triaxial or tetraaxial.
• the photopolymerizable composition comprises a first photopolymerizable macromer component that is triaxial and a second photopolymerizable macromer component that is polyaxial but is not triaxial, e.g., is biaxial or tetraaxial.
• the photopolymerizable composition comprises a first photopolymerizable macromer component that is tetraaxial and a second photopolymerizable macromer component that is polyaxial but is not tetraaxial, e.g., is biaxial or triaxial.
• composition further comprises a light reflective material component to provide an increased polymerization rate at the surface of a photopolymerizable composition where the light contacts the composition in comparison to the same photopolymerizable composition without the light reflective material component.
• photoinitiator component is in a total concentration of less than 1 wt%.
• the photopolymerizable composition further comprises a stabilizer, which is optionally a free radical stabilizer.
• Table 1 identifies 16 prepolymers, uniquely labeled as BCPE 1 through BCPE 16, which may generally be described as having or including compounds of the general formula CC-[arm-OH] according to the present disclosure.
• arm-OH refers to an arm that terminates in a hydroxyl group (OH), i.e., has a hydroxyl end group.
• the prepolymer includes compounds that include the formula CC-[(A)- (B)], i.e., when an arm is formed from residues of monomers from Group A (any one or more of trimethylene carbonate and e-caprolactone) which are proximal to (adjacent to) the central core, and residues of monomers from Group B (any one or more of glycolide, lactide and p-dioxanone) which are the distal to (furthest away from) the central core
• such prepolymers may be prepared by reacting a functionalized central core, also referred to herein as an initiator, with one or more monomers from Group A, followed by reacting that reaction product (referred to herein as a prepolymer precursor) with one or more monomers from Group B.
• Example 1A The preparation of such a prepolymer is illustrated in Example 1A below, where the central core is trifunctional and the functionalized central core / initiator is provided by trimethylolpropane.
• Trimethylene carbonate (1.4 mol) and e-caprolactone (1.4 mol) are co polymerized using trimethylolpropane (0.6 mol) as initiator and stannous octoate (7.0 x 10 5 mol) as catalyst, at 130°C for 72 hours to provide a prepolymer precursor.
• Glycolide (1.1 mol) and additional stannous octoate (2.1 x 10 4 mol) were combined with the prepolymer precursor at 160°C for 3 hours to provide a prepolymer having polyglycolide grafts on the ends of the prepolymer precursor.
• the prepolymer includes compounds that include the formula CC-[(B)- (A)], i.e., when residues of monomers from Group B (glycolide, lactide and p-dioxanone) are proximal to (adjacent to) the central core, and residues of monomers from Group A
• such prepolymers may be prepared by reacting a functionalized central core with one or more monomers from Group B, followed by reacting that reaction product with one or more monomers from Group A. The result is a central core bonded to one or more arms, each arm being hydroxyl terminated and having the formula -(B)-(A)-OH.
• the preparation of such a prepolymer is illustrated in Example IB below, where the central core is trifunctional and the functionalized central core is provided by trimethylolpropane.
• glycolide (1.1 mol) was polymerized with trimethylolpropane (0.6 mol) as initiator and stannous octoate (7 x 10 5 mol) as catalyst, at 160°C for 3 hours to provide a prepolymer precursor.
• stannous octoate (7 x 10 5 mol) was co polymerized onto ends of the prepolymer precursor by adding more stannous octoate (2 x 10 4 mol) and reacting at 130°C for 72 hours.
• polyester prepolymers were synthesized as described in Table 1. All linear samples were synthesized with 1,3-propanediol as the bifunctional initiator, all trifunctional prepolymers were prepared with trimethylolpropane, and 4-arm block copolyester compositions were initiated by pentaerythritol as the tetrafunctional initiator.
• M/I refers to the total moles of monomers (M) used to prepare the arms divided by the moles of initiator (I) (also referred to as the functionalized central core) for each of the copolyesters identified in Table 1.
• M/C refers to the total moles of monomers (M) used to prepare the arms divided by the total moles of catalyst (C) used to prepare each of the copolyester prepolymers identified in Table 1.
• Each of the prepolymers of Table 1 contains a B region, which may either be proximal to the central core (in which case the location of the B region is identified as being central to the prepolymer) or it is distal to the central core (in which case the location of the B region is identified as being at the end of the prepolymer, and in which case the B region terminates in a hydroxyl group).
• Mn refers to number average molecular weight
• Mw refers to weight average molecular weight
• PDI polydispersity (i.e., Mw / Mn)
• Da refers to Daltons.
• BCPE Block copolyester
• BCPE 1 14.3 14,333 Triaxial Center 2.3 48.8 48.8
• BCPE 4 7 14,000 Triaxial Center 28.6 35.7 35.7
• BCPE 6 7 14,000 Triaxial End 28.6 35.7 35.7
• BCPE 8 7 14,000 4-arm Center 42.9 28.6 28.6
• BCPE 11 7 14,000 Triaxial End 75 12.5 12.5
• BCPE 14 7 14,000 Triaxial End — 25 25 50 BCPE 15 7 11,666 Linear End — 37.5 37.5 25
• BCPE 5 2311 ⁇ 23 3766 ⁇ 18 1.63 ⁇ 0.02
• Table 3 identifies 8 Q-functionalized prepolymers, uniquely labeled as BCPE 4Q through BCPE 7Q and BCPE 9Q through BCPE 12Q, which may generally be described as having or including compounds of the general formula CC-[arm-Q] according to the present disclosure.
• the designation arm-Q refers to an arm that terminates in a light-reactive group (Q), such as an acrylate or methacrylate group.
• composition and molecular weight results are outlined in Table 3, and the
• I n Ta ble 3, for BCPE 5Q, 40.15 in the TMC column is the total mole% of TMC plus 1, 3-propanediol used to make BCPE 5Q.
• glycolide residues also referred to herein as glycolide-associated
• TMC or caprolactone residues also referred to herein as TMC or caprolactone associated
• the peak area for protons of the glycolide-associated methacrylate groups, and hence the number of methacrylate groups next to glycolide residues, is higher for BCPE 6Q and BCPE 7Q which have glycolide residue end grafts, compared to BCPE 4Q and BCPE 5Q which have glycolide residue center blocks.
• the area of glycolide-associated methacrylate peaks progressively increases with an increase in the glycolide residue content in the prepolymers while the peaks for methacrylate linked to TMC and caprolactone diminish to negligible levels when the percentage of glycolide residues in the polymer is 50% or above.
• BCPE IQ BCPE 4Q, BCPE 5Q, BCPE 7Q, BCPE 9Q and BCPE 10Q as the starting material, to provide the corresponding crosslinked films BCPE IX, BCPE 4X, BCPE 5X, BCPE 7X, BCPE 9X and BCPE 10X.
• Example 3 Films produced under the conditions described in Example 3 were cut into rectangles with the dimensions of 75 mm (length) by 7.5 mm (width) by 0.75 mm (thickness). Each sample was weighed, and the mechanical properties were evaluated as outlined in Example 3. Samples were then placed in 15 ml of 0.1M phosphate buffer at pH 7.4. The rectangular samples were conditioned at 50 °C for time points of 1, 3, 7, 14, 21, and 56 days. At each time point, the specimens were patted dry and weighed. Afterwards, the samples were dried under vacuum until a constant weight was achieved. Each specimen's dry weight was measured, and intact samples were analyzed for mechanical properties as described in Example 3. In FIGs. 3-6, the results for strength loss, mass loss, and water content for select formulations are reported.
• the modulus of BCPE 7X with the glycolide derived end graft is significantly higher than BCPE 5X with the glycolide derived central block.
• the BCPE 7X (end regions are glycolide derived) films had a faster strength loss through 14 days in comparison to the BCPE 5X (center region is glycolide derived) films.
• the BCPE 5X (center region is glycolide derived) films had a higher strength loss at the last testable time point of 21 days.
• the modulus of BCPE 6X with the glycolide derived end graft is not significantly greater than BCPE4X which has a glycolide derived central block. Also noteworthy is that the BCPE 6X (end region is glycolide derived) films had a faster strength loss than the BCPE 4X (center region is glycolide derived) films. The BCPE 6X films became untestable at 7 days while the BCPE 4X films lasted for an additional 7 days.
• the polymer backbone will be less hydrophilic in comparison to when glycolide derived residues are next to the methacrylate group.
• the same results were observed when comparing the films BCPE 5X and BCPE 7X from the linear prepolymers of BCPE 5 and BCPE 7, respectively. It appears that the block structure or placement of monomer residues has a direct effect on resulting properties. If a relatively fast absorbing monomer residue (e.g., derived from glycolide) is placed at the end of the prepolymer arms, the corresponding crosslinked polymer will have a faster strength loss profile than compared to when glycolide residues are used to form a central block. If a relatively faster absorbing monomer residue (e.g., glycolide residue) is located in the center of the prepolymer, low water content at higher mass losses is observed which may be advantageous.
• a relatively faster absorbing monomer residue e.g., glycolide residue
• the DCC in DCM solution was then added to the reaction vessel drop wise using an addition funnel over a period of 30 minutes. After the addition of DCC/DCM solution had been completed, ice bath was removed. 4-Dimethylaminopyridine (DMAP) (2.366 g; 0.0193 moles) was added to the reaction vessel using a powder funnel. The reaction mixture was continued to stir in nitrogen environment at room temperature for 72 hours. DCM levels were replenished as it evaporated during the reaction. After 72 hours, the reaction mixture was filtered under suction. The filtrate was washed with 2x100 mL 0.25 M HCI and 1x100 mL deionized (Dl) water.
• DMAP 4-Dimethylaminopyridine
• the organic phase from the extraction was dried over activated molecular sieves (3 A) for 18 hours after which it was filtered under suction.
• the solvent was removed under vacuum on a rotary evaporator to get a liquid polymeric product (BCPE 6-TLA).
• Polymers which have hydroxyl groups can be capped with a moiety that replaces the hydroxyl group with a carboxylic acid group.
• the carboxylic acid groups can then be substituted with a thiol containing moiety via an amide or ester bond depending on the functional unit of the substituent employed for bonding.
• the hydroxyl end groups of a BCPE prepolymer see, e.g., Table 1
• BCPE-SA succinated intermediate
• BCPE 6-SA-Cys a product having terminal free thiol groups.
• a three dimensional object was created using the Solidworks ® computer program (Solidworks Corp.) of a rectangular cuboid.
• the three dimensional object file was converted to a STL file.
• the formulation used for this print was 41.6 wt. % BCPE 5, 41.6 wt% PEGDA, 0.2 wt% Irgacure ® TPO-L, and 16.6 wt% polyglycolide microparticles.
• This formulation was added to the ink bed of a B9 Creator vl.2 SLA printer.
• the object was printed at a 30 pm layer thickness with an exposure time of 6s for the first two layers and 3s for subsequent layers.
• the light intensity of the SLA printer was 3 mW/cm 2 when measured by a UVA detector.
• the selected monomer(s) will necessarily include at least one of TMC and CAP, but may also include one or more other, i.e., non-listed, monomers.
• any concentration range, percentage range, ratio range, or integer range provided herein is to be understood to include the value of any integer within the recited range and, when appropriate, fractions thereof (such as one tenth and one hundredth of an integer), unless otherwise indicated.
• any number range recited herein relating to any physical feature, such as polymer subunits, size or thickness are to be understood to include any integer within the recited range, unless otherwise indicated.
• the term "about” means ⁇ 20% of the indicated range, value, or structure, unless otherwise indicated.
• a photopolymerizable compound comprising a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a light-reactive functional group (Q) and (A) is the ring-opening polymerization product from a monomer selected from trimethylene carbonate (T) and e-caprolactone (C), while (B) is the ring- opening polymerization product from a monomer selected from glycolide, lactide and p-dioxanone.
• a light-curable composition comprising one or more photopolymerizable compounds of embodiment 1, optionally further comprising a photoinitiator.
• a light-reactive polyaxial macromer comprising a central core (CC) and 2-4 arms extending from the central core, where at least one of the arms comprises a light-reactive functional group (Q) and a block copolymer comprising blocks A and B; wherein
• a. block A comprises residues formed from at least one of trimethylene carbonate (TMC) and e-caprolactone (CAP); and
• block B comprises residues formed from at least one of glycolide
• a light-curable composition comprising one or more macromers of
• embodiment 3 optionally further comprising a photoinitiator.
• the prepolymer comprises a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a hydroxyl end group (i.e., a hydroxyl group at the end of the arm furthest from the central core) and (A) is the ring-opening polymerization product from a monomer selected from trimethylene carbonate (T) and e-caprolactone (C), while (B) is the ring-opening polymerization product from a monomer selected from glycolide, lactide and p-dioxanone.
• T trimethylene carbonate
• C e-caprolactone
• composition of any of embodiments 1-16 further comprising CC-[A-B-Q] n and n is 1.
• composition of any of embodiments 1-16 further comprising at least one of CC-Q, CC-A-Q, and CC-B-Q.
• composition of any of embodiments 1-16 further comprising at least one of Q-A, Q-B and Q-CC.
• composition of any of embodiments 1-22 wherein block A comprises residues formed from both TMC and CAP.
• composition of any of embodiments 1-22 wherein at least 90% of the residues in block A are residues formed from TMC or CAP.
• composition of any of embodiments 1-22 wherein the macromer comprises 2-45 residues formed from TMC.
• composition of any of embodiments 1-22 wherein the macromer comprises 2-15 residues formed from TMC.
• composition of any of embodiments 1-22 wherein the macromer comprises 2-10 residues formed from TMC.
• composition of any of embodiments 1-35 wherein each B block comprise 2-45 monomer residues.
• composition of any of embodiments 1-36 wherein the block copolymer has a molecular mass of less than 25,000 g/mol. 41) The composition of any of embodiments 1-36 wherein the block copolymer has a molecular mass of less than 10,000 g/mol.
• composition of any of embodiments 1-44 further comprising a
• composition of any of embodiments 1-45 further comprises a reactive diluent such as PEG-diacrylate (PEG-DA).
• a reactive diluent such as PEG-diacrylate (PEG-DA).

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