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• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/04—Anorexiants; Antiobesity agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K38/00—Medicinal preparations containing peptides
  • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
  • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
  • A61K38/22—Hormones
  • A61K38/26—Glucagons
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
  • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
  • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/0012—Galenical forms characterised by the site of application
  • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/08—Solutions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/10—Dispersions; Emulsions

Definitions

• the present invention relates to semaglutide for use in medical therapy in the form of weight management including treatment of obesity.
• Weight management including treatment of obesity, remains a challenge for many.
• GLP-1 RA GLP-1 receptor agonist
• the present invention relates to a method for weight management of a subject in need thereof, wherein said subject is administered semaglutide in an amount of 2.0-4.0 mg once weekly. In some embodiments the present invention relates to a method for weight management of a subject in need thereof, wherein said subject is administered semaglutide in an amount of 2.2-2.7 mg per week.
• the present inventors surprisingly found that it is possible to administer semaglutide at high dosages, for example 2.0-4.0 mg once weekly, while achieving improved weight loss due to an unexpected beneficial ratio between the effect of semaglutide on body weight reduction and the safety profile observed for semaglutide at these high dosages.
• the present inventors also surprisingly found that the effect of semaglutide on body weight reduction continued to improve also through the high dosages of 0.3 and even 0.4 mg once daily.
• the present inventors also surprisingly found that the increase in safety profile, including gastrointestinal adverse events, at these high dosages surprisingly was lower than the improvement in body weight reduction. This is shown in the experimental section, where the change in the number of reported gastrointestinal adverse events was lower than change in body weight reduction for the high dosages of 0.3 and 0.4 mg once daily.
• safety profile refers to adverse effects of an administered drug or other substance and includes gastrointestinal adverse events, such as nausea.
• increase in safety profile refers to an increase in safety events, such as an increase in gastrointestinal adverse events.
• the methods of the present invention provide acceptable tolerability while improving the treatment, e.g. improved weight management in the form of increased body weight loss.
• safety profile refers to tolerability.
• gastrointestinal adverse event refers to symptoms of the system organ class gastrointestinal disorders as defined by the MedDRA classification (e.g. version 19.1 ).
• gastrointestinal adverse event refers to symptoms selected from the group consisting of nausea, vomiting, diarrhoea and constipation.
• gastrointestinal adverse event refers to nausea.
• the present invention relates to a method for weight management of a subject in need thereof, wherein said subject is administered semaglutide in an amount of 2.0-4.0 mg once weekly. In some embodiments the present invention relates to a method for weight management of a subject in need thereof, wherein said subject is administered semaglutide in an amount of 2.2-2.7 mg per week.
• the method of the present invention provides an improved body weight reduction which also is relatively greater than the increase in gastrointestinal adverse events (such as nausea), particularly at the high semaglutide dosages of 0.3-0.4 mg per day (such as 2.2-2.7 mg per week or 2.0-4.0 mg once weekly).
• the method of the present invention provides an improved ratio between body weight reduction and gastrointestinal adverse events.
• the present invention relates to a method for treating type 2 diabetes in a subject in need thereof, wherein said subject is administered semaglutide in an amount of 2.0-4.0 mg once weekly. In some embodiments the present invention relates to a method for treating type 2 diabetes in a subject in need thereof, wherein said subject is administered semaglutide in an amount of 2.2-2.7 mg per week. Semaglutide
• the GLP-1 RA semaglutide may be prepared as described in WO2006/097537, Example 4. Semaglutide is also known as N 6 26 - ⁇ 18-[N-(17-carboxyheptadecanoyl)-L-v- glutamyl]-10-oxo-3,6,12, 15-tetraoxa-9,18-diazaoctadecanoyl ⁇ -[8-(2-amino-2-propanoic acid),34-L-arginine]human glucagon-like peptide 1 (7-37), see WHO Drug Information Vol. 24, No. 1 , 2010.
• semaglutide is administered by injection. In some embodiments semaglutide is administered by injection.
• semaglutide is administered subcutaneously, such as via subcutaneous injection.
• the amount of semaglutide administered per week is 2.2-2.7 mg. In some embodiments the amount of semaglutide administered per week is selected from the group consisting of 2.2-2.7 mg, 2.2-2.6 mg, and 2.3-2.5 mg. In some embodiments the amount of semaglutide administered per week is selected from the group consisting of 2.2 mg, 2.3 mg, 2.4 mg, 2.5 mg, 2.6 mg, and 2.7 mg.
• semaglutide is administered once daily or once weekly.
• semaglutide is administered once daily in an amount selected from the group consisting of 0.32-0.37 mg, 0.32-0.36 mg, and 0.33-0.35 mg once daily. In some embodiments semaglutide is administered once daily in an amount selected from the group consisting of 0.32 mg, 0.33 mg, 0.34 mg, 0.35 mg, 0.36 mg, 0.37 mg, and 0.37 mg once daily.
• semaglutide is administered once weekly in an amount selected from the group consisting of 2.0-10.0 mg once weekly. In some embodiments semaglutide is administered once weekly in an amount selected from the group consisting of 2.0-4.0 mg once weekly. In some embodiments semaglutide is administered once weekly in an amount selected from the group consisting of 2.1 -3.8 mg, 2.2-3.6 mg, and 2.3-3.4 mg. In some embodiments semaglutide is administered once weekly in an amount selected from the group consisting of 2.4-3.2 mg, 2.2-3.0 mg, and 2.0-2.8 mg. In some embodiments semaglutide is administered once weekly in an amount selected from the group consisting of 2.4-3.0 mg, 2.2-2.9 mg, and 2.0-2.8 mg.
• semaglutide is administered once weekly in an amount selected from the group consisting of 2.4-2.7 mg, 2.2-2.6 mg, and 2.0-2.5 mg. In some embodiments semaglutide is administered once weekly in an amount selected from the group consisting of about 2.2 mg, about 2.3 mg, or about 2.4 mg. In some embodiments semaglutide is administered once weekly in an amount selected from the group consisting of about 2.5 mg, about 2.6 mg, and about 2.7 mg.
• the drug substance administered according to the method of the present invention consists of semaglutide. Indications
• the present invention relates to a method for weight management.
• the weight management is chronic weight
• the said weight management is selected from the group consisting of: reducing body weight, treating and/or preventing obesity, treating and/or preventing overweight, and preventing weight gain.
• the present invention relates to a method for reducing body weight.
• the present invention relates to a method for treating and/or preventing obesity.
• the present invention relates to a method for treating and/or preventing overweight.
• the present invention relates to a method for preventing weight gain.
• the term "overweight" as used herein refers to the condition wherein the subject has a BMI of at least 27, such as at least 27 to less than 30, including any number in between.
• the term "obesity” as used herein refers to the condition wherein the subject has a BMI of at least 30, such as at least 30 to less than 35, at least 35 to less than 40, or at least 40, including any number in between 30 and 40.
• BMI refers to the weight of a subject in kilograms divided by the square of the height of this subject in meters; BMI has the unit of kg/m 2 .
• the method of the invention provides an improved weight loss due to an unexpected beneficial ratio between the effect of semaglutide on body weight reduction and on gastrointestinal adverse events, such as nausea.
• the method of the invention reduces gastrointestinal adverse events in said subject.
• the method of the invention reduces gastrointestinal adverse events in the form of nausea in said subject.
• the term "reduces gastrointestinal adverse events" as used herein refers to the occurrence of fewer gastrointestinal adverse events, e.g. in comparison to other dosages of semaglutide.
• the subject of the method of the invention is human. In some embodiments the subject of the method of the invention is adult. In some embodiments the subject of the method of the invention is a child (e.g. 2-1 1 years of age). In some
• the subject of the method of the invention is an adolescent (e.g. 12 to less than 18 years of age, such as 12 to 16 years of age or 12 to less than 16 years of age).
• the subject of the method of the invention has type 2 diabetes.
• the subject treated according to the methods of the present invention is obese (e.g. BMI ⁇ 30 or as defined herein in relation to the term "obesity") or overweight (e.g. BMI ⁇ 27 and BMI ⁇ 30 or as defined herein in relation to the term "overweight”).
• the subject in the methods of the present invention has at least one weight-related comorbid condition (such as hypertension, type 2 diabetes mellitus, or dyslipidemia).
• the subject of the method of the invention has sleep apnoea and/or urine incontinence. In some embodiments the subject in the methods of the present invention has at least one weight-related comorbid condition selected from the group consisting of hypertension, type 2 diabetes mellitus, dyslipidemia, sleep apnoea, and urine incontinence.
• semaglutide is administered in the form of a pharmaceutical composition further comprising one or more pharmaceutically acceptable excipients, for example selected from the group consisting of buffer, isotonic agent, and preservative.
• pharmaceutical composition and “composition” are used interchangeably herein and refer to a pharmaceutical composition.
• the composition is in the form of a solution or a suspension, such as an aqueous solution.
• pH of said composition is in the range of 6.0-10.0, such as 6.5-9.0 or 7.0-8.0.
• pH of said composition is in the range of 7.1 -7.8, such as 7.2-7.6 or 7.3-7.5.
• pH of said composition is about 7.4.
• concentration of semaglutide in said composition is 0.01 -50 mg/ml, such as 0.05-20 mg/ml or 0.1-10 mg/ml.
• concentration of semaglutide in said composition is 0.01 -5 mg/ml, such as 0.05-2 mg/ml.
• the composition comprises a buffer, such as phosphate buffer.
• the composition comprises an isotonic agent, such as propylene glycol.
• the composition comprises a preservative, such as phenol.
• the drug substance in the composition consists of semaglutide.
• semaglutide is administered in the form of an aqueous composition comprising 4.1 mg/ml semaglutide, phosphate buffer, propylene glycol, phenol as preservative, at pH 7.4.
• semaglutide is administered in the form of an aqueous composition comprising 4.1 mg/ml semaglutide, 1.42 mg/ml disodium hydrogen phosphate dihydrate, 14.0 mg/ml propylene glycol, 5.50 mg/ml phenol, at pH 7.4.
• the composition pH is adjusted using hydrochloric acid and/or sodium hydroxide.
• the term "a” means "one or more”.
• specific values mentioned herein and given in relation to numbers or intervals may be understood as the specific value or as about the specific value.
• the term “about” refers to ⁇ 10% of the value referred to.
• terms presented in singular form also include the plural situation.
• weight management is selected from the group consisting of:
• said amount of semaglutide administered per week is selected from the group consisting of 2.2 mg, 2.3 mg, 2.4 mg, 2.5 mg, 2.6 mg, and 2.7 mg.
• administration is once daily or once weekly.
• semaglutide is administered once weekly in an amount selected from the group consisting of 2.1 -3.8 mg, 2.2-3.6 mg, and 2.3-3.4 mg. 13. The method according to any one of the preceding embodiments, wherein said semaglutide is administered once weekly in an amount selected from the group consisting of 2.4-3.2 mg, 2.2-3.0 mg, and 2.0-2.8 mg.
• semaglutide is administered once weekly in an amount selected from the group consisting of 2.4-3.0 mg, 2.2-2.9 mg, and 2.0-2.8 mg.
• semaglutide is administered once weekly in an amount selected from the group consisting of 2.4-2.7 mg, 2.2-2.6 mg, and 2.0-2.5 mg.
• semaglutide is administered once weekly in an amount selected from the group consisting of 2.2 mg, 2.3 mg, 2.4 mg, 2.5 mg, 2.6 mg, and 2.7 mg.
• semaglutide is administered subcutaneously, such as via subcutaneous injection.
• composition is in the form of a solution or a suspension, such as an aqueous solution. 22. The method according to any one of the preceding embodiments, wherein the pH of said composition is in the range of 6.0-10.0, such as 6.5-9.0 or 7.0-8.0.
• pharmaceutically acceptable excipients comprises one or more excipients selected from the group consisting of isotonic agent, buffer, and preservative.
• concentration of semaglutide in said composition is 0.01 -50 mg/ml, such as 0.05-20 mg/ml or 0.1 -10 mg/ml. 26. The method according to any one of the preceding embodiments, wherein the concentration of semaglutide in said composition is 0.01-5 mg/ml, such as 0.05-2 mg/ml.
• substance administered consists of semaglutide.
• Example 1 Semaglutide in obese subjects
• a clinical trial was carried out in order to assess and compare the dose-response of five doses of once-daily semaglutide versus once-daily liraglutide 3.0 mg and/or placebo in inducing and maintaining weight loss after 52 weeks in obese subjects without diabetes mellitus.
• This trial was designed as a 52-week, randomised, double-blind, placebo-controlled, sixteen-armed, parallel group, multi-centre, multinational trial comparing once-daily subcutaneous administration of semaglutide in five different doses (ranging from 0.05 mg/day to 0.4 mg/day) with placebo in obese subjects without diabetes mellitus.
• Liraglutide 3.0 mg/day was included as an active comparator.
• the trial was double-blinded between active and placebo treatment. To ensure a sufficiently large sample of men, no more than 70% of the trial population was allowed to be women and the randomisation was stratified according to sex. Subjects were randomised in a balanced manner (6:1 active:placebo).
• the primary endpoint was relative change from baseline in body weight (%) at 52 weeks.
• Key secondary endpoints included proportion of subjects with weight loss of ⁇ 5% or ⁇ 10% of baseline body weight at 52 weeks as well as change in body weight from baseline to 52 weeks.
• Supportive secondary safety endpoints also included gastrointestinal (Gl) adverse events (i.e. nausea, vomiting, diarrhoea and constipation).
• Gl gastrointestinal
• adverse events i.e. nausea, vomiting, diarrhoea and constipation.
• All medical problems either observed by the site staff or the subject was reported as an adverse event and evaluated for severity and causality by the investigator. For this trial the subjects had site visits every 2 weeks for the first 20 weeks of the trial and afterwards site visits was performed every 4 weeks.
• the treatment arms were: (A) semaglutide at randomised target dose 0.05, 0.1 , 0.2, 0.3, or 0.4 mg (for dose levels above 0.05 mg, dose escalation took place every fourth week); (B) semaglutide at randomised target dose 0.3 or 0.4 mg (starting dose 0.05 mg with dose escalation every second week); (C) liraglutide 3.0 mg (starting dose 0.6 mg with dose escalation every week); and (D) placebo (matching each of the active treatment arms); all administered via subcutaneous injection.
• Subjects in all treatment arms including placebo received nutritional counseling and a calorie-reduced diet by a dietician or equivalent qualified delegate as well as physical activity counseling by a qualified person on a monthly basis beginning at the randomisation visit.
• the trial population consisted of a total of 957 subjects were randomised. A total of 777 subjects (81.2%) completed 52 weeks of treatment; 180 (18.8%) discontinued treatment prematurely with no obvious dose-dependent trend.
• Key inclusion criteria for this trial were: Male or female, age ⁇ 18 years at the time of signing inform consent; body mass index (BMI) ⁇ 30.0 kg/m2 at the screening visit; and at least one unsuccessful weight loss attempt per investigator judgement.
• the primary analysis was based on a 'jump- to-reference' multiple imputation approach (J2R-MI). Week 52 data from subjects who discontinued trial product and returned for the visit at week 52 were included in the analysis. First, an imputation model using observed week 52 body weight (kg) measurements from the placebo arm only were estimated. Second, multiple copies (1000) of the full analysis set were generated by imputing missing values in all treatment arms from the imputation model. The primary endpoint was calculated in each complete data set and analysed using an analysis of covariance (ANCOVA) model. Third, the 1000 analysis results were summarised using Rubin's formula.
• J2R-MI 'jump- to-reference' multiple imputation approach
• Table 1 Baseline characteristics of subjects per treatment arm, presented as mean (SD)
• Table 2 Change in body weight (%) from baseline to week 52 by treatment arm - descriptive statistics - observed data - full analysis set
• Subjects in-trial Subjects on-treatment as well as subjects who discontinued treatment prior to trial end but presented at the week 52 visit.
• Table 3 Change in body weight (%) from baseline to week 52 by treatment arm and treatment differences - primary statistical analysis - ANCOVA - J2R-MI - full analysis set
• Lira Liraglutide
• Sema Semaglutide
• * The dose-response coefficients were estimated via an Emax three parameter model, ** : Based on %.
• Table 5 Summary of gastrointestinal adverse events in subjects on-treatment - observed data and results from Emax dose-response modelling - full analysis set
• Lira Liraglutide
• Sema Semaglutide
• N Number of subjects
• N e Number of subjects experiencing at least one event
• % Percentage of subjects with at least one event
• * The dose-response coefficients were estimated via an Emax three parameter model, ** : Based on %.
• Table 6 Summary of gastrointestinal adverse events in the form of nausea in subjects treatment - observed data - full analysis set
• Lira Liraglutide
• Sema Semaglutide
• N Number of subjects
• N e Number of subjects experiencing at least one event
• % Percentage of subjects experiencing at least one event
• E Number of events
• the results in Tables 4-5 show that the dosage of semaglutide providing the same body weight reduction as 3.0 mg liraglutide is 0.08 mg semaglutide (with a 95% CI of [-0.02;0.57]) whereas the dosage of semaglutide providing the same level of gastrointestinal adverse events as 3.0 mg liraglutide is 0.28 mg semaglutide (with a 95% CI of [-0.02;0.57]); thus semaglutide provides around 3 times greater body weight reduction at the same level of gastrointestinal adverse events (the around 3 times was calculated as (3.0/0.08)/(3.0/0.28).
• Example 2 Semaglutide in subjects with type 2 diabetes
• Trial drug administration Following a 2-week screening period, patients received trial medication for 26 weeks, followed by a 7-week follow-up period. Patients were initiated on treatment with 0.05 mg semaglutide, 0.3 mg liraglutide or 50 ⁇ _ placebo, all administered subcutaneously once daily, and titrated every 4 weeks up to their final randomized dose. This titration algorithm was used in all patients to ensure blinding across the products, and thus liraglutide was escalated at a slower pace than recommended in the label. The trial was double blinded within (but not between) each dose level of semaglutide, liraglutide and placebo, as treatment was volume matched.
• Table 8 Mean change in body weight and gastrointestinal adverse events, including from baseline to week 26 - on-treatment - estimated data
• Lira Liraglutide
• Sema Semaglutide
• N Number of subjects
• N e number of patients experiencing at least one event
• % percentage of patients experiencing at least one event
• E number of events.
• Lira Liraglutide
• Sema Semaglutide
• N Number of subjects
• SD Standard Deviation

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