WO2019066601A2 - 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물 - Google Patents

두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물 Download PDF

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WO2019066601A2
WO2019066601A2 PCT/KR2018/011610 KR2018011610W WO2019066601A2 WO 2019066601 A2 WO2019066601 A2 WO 2019066601A2 KR 2018011610 W KR2018011610 W KR 2018011610W WO 2019066601 A2 WO2019066601 A2 WO 2019066601A2
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WIPO (PCT)
Prior art keywords
extract
composition
preventing
hair
scalp
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PCT/KR2018/011610
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English (en)
French (fr)
Korean (ko)
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WO2019066601A3 (ko
Inventor
박진오
이지원
박병권
최아람
김아름
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유씨엘 주식회사
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Priority to CN201880054526.4A priority Critical patent/CN111132654B/zh
Publication of WO2019066601A2 publication Critical patent/WO2019066601A2/ko
Publication of WO2019066601A3 publication Critical patent/WO2019066601A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present invention relates to a cosmetic composition having an effect of preventing and alleviating inflammation of the scalp and preventing hair loss.
  • alopecia refers to an increase in the number of abnormal hair loss due to shortening of hair growth rate in the growing period and increased number of hair in the retrogressive or resting period among these cycles.
  • the cause of known hair loss may be influenced by various factors such as age, season, race, physiological factors, and disease, but it can be affected by 1) male hormone hyperactivity, 2) excessive sebaceous secretion, 3) 4) depression of the scalp due to peroxidation and bacteria, 5) genetic factors, 6) aging, and 7) stress.
  • dandruff diseases such as dandruff and seborrheic dermatitis are widely known to be accompanied by typical early symptoms.
  • scalp inflammation is caused by various pollutants, skin hypersensitivity to bacteria.
  • the genetic factors such as nervous system disorder, blood circulation disorder, excessive sebum production caused by abnormal circulatory system, nutritional deficiency of hair follicle, allergy, bacterial infection, hormone effect, various pollution.
  • a combination of mental and social factors and aging of modern people who are frequently exposed to environmental factors and excessive stress such as shampoo, soap, mousse, hair gel, hair spray, permer, dyeing, hair dryer and detergent are known.
  • hair loss products including effective ingredients such as blood circulation promotion, hair root enhancement effect, scalp moisturizing effect, anti-dandruff effect, antioxidant effect, hair growth period extension effect and suppression of male hormone function.
  • effective ingredients such as blood circulation promotion, hair root enhancement effect, scalp moisturizing effect, anti-dandruff effect, antioxidant effect, hair growth period extension effect and suppression of male hormone function.
  • efficacy it has not yet been proven to have significant effects, and side effects may be raised.
  • Patent Document 1 can be exemplified as a conventional technology for an anti-hair loss agent using such a natural extract.
  • the patent discloses a composition for preventing hair loss or promoting hair growth, comprising a mixed extract of green tea and amaranthus, or a mixed extract of green tea, green tea and hibiscus as an active ingredient, and discloses a natural combination extract. The effectiveness is significantly different.
  • Patent Document 1 KR 10-1780692 B1 (May 27, 2017)
  • An antioxidant composition comprising menthol, salicylic acid, dex-panthenol, hosepat, frequent mugwort extract, and bokbunja strawberry extract.
  • the composition provides an anti-depressant composition having an effect of alleviating, preventing and preventing scalp inflammation.
  • the composition may further comprise 0.05 to 2 wt% of menthol, 0.05 to 2 wt% of salicylic acid, 0.05 to 15 wt% of dexpanthenol, 0.01 to 20 wt% of hose fat, 0.01 to 20 wt% By weight of a common astringent extract, and 0.01-20% by weight of a brambleberry extract.
  • the composition may further comprise one or more additional extracts selected from the group consisting of marigold extract, crude extract, propolis extract, bipari leaf extract, mulberry bark extract, black sea bream leaf extract, turmeric extract, / RTI >
  • the above-mentioned additional extract is provided with an anti-alopecic composition having a total content of 0.01-20 wt% based on the total weight of the composition.
  • a cosmetic comprising the composition of the present invention and made from a formulation selected from creams, lotions, essences, serums, toners, tonics, and mists.
  • the present invention has an effect of preventing, alleviating and preventing a scalp disease such as scalp inflammation, thereby improving hair loss prevention effect.
  • Fig. 1 is a comparative photograph showing the effect of preventing and treating hair loss before and after use of the hair loss preventing agent of the present invention and the skin soothing effect.
  • first, second, A, B, (a), (b), and the like can be used. These terms are intended to distinguish the constituent elements from other constituent elements, and the terms do not limit the nature, order or order of the constituent elements.
  • " about, " " substantially, " and " degree ", etc. used to describe the present invention should be understood to include both manufacturing and material tolerances inherent to the stated meanings, And is used to prevent unauthorized use by an unscrupulous infringer of an explicit or absolute number for the purpose of facilitating the understanding of the present invention.
  • An anti-depressant composition for relieving scalp inflammation may include menthol, salicylic acid, dexpanthenol, hosepat, safflower extract, and bokbullu strawberry root extract.
  • the menthol is a component used for stomach cramps and toothache, and is good for pain and inflammation, and has an effect of cooling the scalp, so that the feeling of cooling of the scalp can be added.
  • the menthol preferably contains 0.05-2% by weight, more preferably 0.1-1.0% by weight, based on the total weight.
  • the content of menthol When the content of menthol is less than 0.05% by weight, the efficacy and the effect are insignificant. When the content of menthol is more than 2% by weight, excessive cooling or irritation may occur and the formulation may be unstable.
  • the salicylic acid is widely used for skin-related diseases such as acne, dandruff, keratin and corn, and has a property of softening the anti-inflammatory and scalp keratin so as to remove old keratin and waste products remaining inside the pores You can do it.
  • Salicylic acid preferably contains 0.05-2% by weight based on the total weight of the composition, and if it exceeds 0.1-1% by weight, skin irritation may occur.
  • Dex Panthenol is a protein that is converted into vitamins after being absorbed into the body. It can prevent inflammation and itching, soften hair, and enhance hair strength.
  • the dexpanthenol preferably contains 0.05-15% by weight, more preferably 0.1-10.0% by weight.
  • Hoosefat is an excellent antioxidant and anti-inflammatory ingredient. It can prevent skin homeostasis and skin aging by promoting ARE activity related to antioxidant protein Nrf-2.
  • the hose fat preferably contains 0.01-20 wt%, more preferably 0.1-10 wt%, of the total weight.
  • the content of the hose fat is less than 0.01% by weight, the effect and the effect are insignificant.
  • the content of the hose fat is more than 20% by weight, stability of the formulation and storage stability may occur.
  • Thyme extracts are highly cytotoxic and have excellent antitumor effects by inhibiting various cytokines and NO activity mediated by inflammatory responses. They are highly effective in preventing skin aging and strengthening skin barrier because of their high antioxidant effect.
  • the safflower extract contains 0.01 to 20% by weight, more preferably 0.1 to 10% by weight.
  • the content of the Thyme Extract is less than 0.01% by weight, the efficacy and the effect are insignificant. If the content is more than 20% by weight, stability of the formulation and storage stability may occur.
  • Rubus root extract of bokbunja is an excellent anti-inflammatory and moisturizing ingredient. It can suppress excess sebum secretion, inhibit hyperkeratosis and enhance skin moisturizing effect.
  • the bramble strawberry root extract preferably contains 0.01-20% by weight, more preferably 0.1-10% by weight.
  • the content of the bokbunja strawberry root extract is less than 0.01% by weight, the efficacy and the effect are insignificant. If the content is more than 20% by weight, problems such as stability of the formulation and storage stability may occur.
  • one or more kinds of the extracts selected from the group consisting of marigold extract, crude extract, propolis extract, bipari leaf extract, bamboo extract, mulberry leaf extract, turmeric extract, Extract. ≪ / RTI >
  • Mahi-hyeon is a leaf-like shape resembling a horse's tooth, a duckling in the shape of a horse, or in other words, a pair of leggings. It is known that there are many omega - 3 fatty acids, which are a type of unsaturated fatty acid, and this extract has excellent antioxidative and anti - inflammatory properties.
  • the propolis is excellent in organic matter and minerals. Especially, minerals, vitamins, amino acids, fats, organic acids, flavonoids and the like play an important role in cell metabolism, terpenes and the like have anticancer activities, and flavonoids help health promotion give. This propolis has anti-inflammatory, antioxidant, immunity enhancing effects.
  • the Biparanthus japonicus is cultivated in Korea (Jeju Island, South coast), Japan and China. It is known to contain antioxidant and anti-cancer effects because it contains tannin. Among them, the leaves of Biparakis contain a large amount of tannin and amigalline components, and it has a high bactericidal action and a high anti-inflammatory effect, which is effective for improving heat rash, eczema and skin inflammation.
  • the mallow bark is a mulberry bark that contains ingredients such as ascorbic acid, kojic acid, arbutin, hydroquinone, and glutathione to inhibit tyrosinase activity that promotes melanin activity, thereby exhibiting excellent whitening efficacy, as well as antibacterial, moisturizing, It has excellent antioxidant effect and can help scalp soothing and hair growth.
  • the safflower leaf extract contains essential oils such as calcium, phosphorus, iron, vitamins and camphor, coumarins, chromones, flavonoids and caffeic acid, , Antioxidant activity, effect of allergic dermatitis, improvement effect on atopy, and the like.
  • the turmeric is an annual plant with ginger and is mainly cultivated in tropical and subtropical areas, mainly in India. Korea is cultivated in Jeonnam, Jindo, Jeonnam, Haenam, Jeonbuk Buan, Gyeonggi Siheung and Chungnam Cheongyang.
  • Turmeric is a spicy, bitter, yellow medicinal substance that can be used for pain relief, bruises and sprains, and is highly antioxidant and anti-inflammatory.
  • Ishigaki is an Araliaceae plant which is a reclaimed land of Jeju Island. It has been known that it is used for medicinal purposes since the Goryeo period, and the shells of roots, stems and branches are called ogapi, the leaves are called ogabi, Acanthopanax nucifera extract has excellent antioxidant and anti-inflammatory properties.
  • the anti-depilator composition according to the present invention is not only excellent in efficacy as an anti-depilator, but also can prevent, alleviate and prevent scalp diseases such as scalp inflammation, thereby alleviating and reducing hair loss, It is obvious that it can be improved.
  • the anti-depressant composition can be manufactured in formulations such as cream, lotion, essence, serum, toner, tonic, mist, etc., and can prevent the scalp disease from being prevented, And can be used for cosmetic purposes.
  • composition ratios of Production Example 1-7 and Comparative Example 1-2 described in the following Table 1 purified water, glycerin, butylene glycol, 1,2hexanediol, disodium edetate were dissolved and heated to about 70 ° C
  • solution 1 was mixed with a mixture of caprylic / capric triglyceride, triethylhexanone, cetearyl alcohol, cyclopentasiloxane, palmitic acid, stearic acid, cyclohexasiloxane, Sorbate 60, PGI-100 stearate, glyceryl stearate, and sorbitan stearate were added and heated to about 70 ° C to dissolve them to prepare solution 2.
  • the solution 2 thus prepared was added to Solution 1, mixed, emulsified and cooled.
  • the components 3 were added and uniformly mixed to prepare an anti-depilation composition having an effect of alleviating the scalp inflammation.
  • the anti-hair-loss composition having the effect of preventing, alleviating, and preventing scalp inflammation produced according to the above Table 1 was applied to each adult male and female after hair was wound around them in the morning and evening. After 6 months, The amount of hair growth, hair thickness and hair density were measured according to the evaluation method, and the average value was evaluated.
  • a total of 18 adult male and female adult male and female alopecia suppressor compositions having the effect of preventing, alleviating, and preventing scalp inflammation according to the present invention were removed after hair cleansing before use and after 6 months (24 weeks) of use
  • the number of hairs was measured and evaluated according to the evaluation criteria shown in Table 2 below. The results are shown in Table 3-4.
  • Folliscope 4.0 (Lead M, Korea), a device for analyzing the characteristics of hair based on photographs taken using a high resolution digital close-up camera, was used to measure the thickness of the hair by phototrichogram. was used to measure the test site.
  • the measurement method used was a scalp of a certain area (1 cm 2), and the average value of five hairs in the hair was used as evaluation data. The results are shown in Table 4 and FIG.
  • Folliscope 4.0 (Lead M, Korea), a device for analyzing the characteristics of hair based on photographed photographs using a high-resolution digital close-up camera, was used to measure the hair density, which was measured by phototrichogram. was used to measure the test site.
  • the number of hairs in the area was used as evaluation data for the scalp of a certain area (1 cm 2), and the results are shown in Table 5.
  • composition of hair loss preventing agent having the effect of preventing, alleviating, and preventing scalp inflammation produced according to the above Table 1 was applied to each adult male and female in the morning and evening after hair was wound around them. After 6 months, Moisture content was measured according to a predetermined evaluation method.
  • Scalp sedation was measured by Image-pro plus using a Folliscope.
  • the pixel value of the area occupied by the red color was obtained from the image of the scalp girdle area before and after the use of the anti-depressant composition having the effect of alleviating the scalp irritation.
  • the area of the pixel decreased. It means that the scalp calming effect is high.
  • the scalp calming standard of Table 6 evaluated according to the scalp calming standard of Table 6 below.
  • the moisture content of the scalp was measured using a Corneometer CM825 (Courage-Khazaka electronic GmbH, Germany). Measurements were made three times through a sensor with a corneometer probe on the skin, and the average value was used as the skin moisture content evaluation data.
  • the Corneometer is a device that basically treats skin as a non-conductive material and applies electricity with a higher water content. It measures the capacitance at the point where the probe touches. Therefore, the moisture content and the capacitance are proportional to each other, and the higher the measured value, the higher the moisture content.
  • the water content which is within 30-40 micrometer depth downward from the stratum corneum of the skin, is constantly measured, and the unit is the unit constant, the arbitrary unit (A.U).
  • Example 1-7 using the hair anti-scalp anti-irritant composition of the present invention showed 300-650% The water content of the scalp increased.

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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PCT/KR2018/011610 2017-09-29 2018-09-29 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물 WO2019066601A2 (ko)

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Application Number Priority Date Filing Date Title
CN201880054526.4A CN111132654B (zh) 2017-09-29 2018-09-29 具有预防和缓解头皮炎症及预防脱发的效果的化妆品组合物

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KR10-2017-0127460 2017-09-29
KR1020170127460A KR102020667B1 (ko) 2017-09-29 2017-09-29 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물

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KR20230050806A (ko) * 2021-10-08 2023-04-17 제주대학교 산학협력단 삼다차조 추출물을 포함하는 탈모의 예방 또는 치료를 위한 조성물
KR102622831B1 (ko) * 2021-10-08 2024-01-09 제주대학교 산학협력단 삼다차조 추출물을 포함하는 탈모의 예방 또는 개선을 위한 조성물
KR102425008B1 (ko) * 2022-01-24 2022-07-25 주식회사 코스웹 스마트 커스터마이징 화장품 제작 시스템
KR102484698B1 (ko) * 2022-05-17 2023-01-04 주식회사 에스오디랩 항산화 효소가 함유된 탈모개선 제품 및 그 제조 방법

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KR100769260B1 (ko) * 2006-08-25 2007-10-22 주식회사 태웅이엘에스 희토원소를 함유하는 모발 개선용 조성물
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KR20140141274A (ko) * 2013-05-31 2014-12-10 주식회사 씨엘디 테크놀러지 발모 촉진 또는 탈모 방지용 조성물
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WO2019066601A3 (ko) 2019-05-23
KR20190037777A (ko) 2019-04-08
CN111132654B (zh) 2022-11-04
KR102020667B1 (ko) 2019-09-10

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