Classifications

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  • A61K2800/222—Effervescent

Definitions

• the present invention relates to a non-aqueous carbon dioxide external preparation which can be used simply by applying to the skin or by additionally supplying water.
• a carbon dioxide external preparation comprising a combination of a water-containing viscous composition containing an acid or a carbonate, and granules containing an acid or a carbonate, wherein the water-containing viscosity composition or the acid is mixed with the water-containing viscosity composition and the granules Composition for the preparation of an external preparation for carbon dioxide in which carbon dioxide is generated by the reaction of carbon dioxide with carbon dioxide (see Patent Documents 1 to 5); a viscous material containing at least an acid and water in a polymer three-dimensional network structure having elasticity It is impregnated, and it comprises a main agent which is brought into contact with the skin at the time of use, and a reactive agent containing at least a carbonate which generates carbon dioxide by contacting the main agent at the time of use, to generate carbon dioxide by the reaction of the main agent and the reactive agent Material for preparation of external preparation for carbon dioxide (refer to Patent Document 6); (A) non-aqueous liquid composition containing carbonate or bicarbonate, and (B
• a carbon dioxide external preparation consisting of two or more agents including a water-containing viscosity composition
• the water-containing viscosity composition can contain only either an acid or a carbonate, and water occupies most of its weight, so carbon dioxide It is difficult to reduce the weight of the external preparation.
• a carbon dioxide external preparation consisting of two or more agents must be mixed at the time of use to generate carbon dioxide, and the resulting carbon dioxide external preparation should be applied to the desired site, It took time and effort.
• the effervescent skin cosmetic disclosed in Patent Document 9 is reduced in weight because it is substantially non-aqueous
• the concrete disclosed in Examples 1 to 10 is a two-component type. It is a carbon dioxide external preparation.
• the inventor uses as an essential component a paste base (hereinafter, also simply referred to as “base”), an alcohol, a carbonate, an acid and / or a substance capable of generating an acid by hydrolysis (hereinafter, “acid substitute”)
• base an alcohol, a carbonate, an acid and / or a substance capable of generating an acid by hydrolysis
• acid substitute a substance capable of generating an acid by hydrolysis
• the carbon dioxide external preparation of the present invention is adhesive, it can be applied to the skin, cloth, etc., and by simply applying it to the skin or by additionally supplying water, vasodilation and muscle strengthening Specific actions of carbon dioxide such as action to improve fatigue recovery, antitumor action by cancer cell specific apoptosis inducing action, bone fracture promoting action, wound healing promoting action, lipid metabolism promoting action, skin beautifying action, pigmentation improving action, etc. The effect is obtained, it is convenient to carry and easy to use.
• the carbon dioxide external preparation of this invention can provide the carbon dioxide gas pack agent known before by adding and melt
• the paste base, alcohol, carbonate, acid and / or substance capable of generating an acid by hydrolysis form a paste, and carbon dioxide generation reaction does not occur until water is supplied. It coexists stably.
• the carbon dioxide external preparation of the present invention is basically non-aqueous, but some water content is acceptable.
• the upper limit of the water content of the alcohol, which varies depending on the ingredients, is approximately 2%.
• the allowable upper limit of water content is about 1.8%.
• the paste in the present invention is a fluid which can be thinly extended and which has viscosity and adhesiveness such that it does not drip when applied to skin, cloth or the like.
• the paste base in the present invention refers to a substance that imparts viscosity to an alcohol, and a carboxyvinyl polymer is suitable as the paste base.
• the alkyl-modified carboxyvinyl polymer is considered equivalent to the carboxyvinyl polymer, and can be used instead of or together with the carboxyvinyl polymer.
• bicarbonate is considered equivalent to carbonate and can be used in place of, or with carbonate.
• the carbonate and the acid and / or the substance that generates an acid by hydrolysis are dissolved and reacted to generate carbon dioxide.
• the external preparation for carbon dioxide of the present invention when the skin contains appropriate water, is applied to the skin only, and the alcohol of the external preparation mainly absorbs the water of the skin, and the external medicine for the external preparation according to the water Is dissolved and reacted with an acid and / or a substance capable of generating an acid by hydrolysis to generate carbon dioxide. At this time, the generated carbon dioxide is absorbed from the skin immediately and produces an action with almost no bubble formation.
• the target site may be immersed in water, covered with a wet towel etc., exposed to steam, covered with a polymer film or the like.
• the surface of the external preparation may be sprayed with water, exposed to steam, covered with a wet towel or the like, and supplied with water.
• the skin may be steamed by covering with a polymer film or the like.
• a carboxyvinyl polymer is suitable, and as the carboxyvinyl polymer, any polyvinyl alcohol and any water soluble one can be used without particular limitation.
• a carboxyvinyl polymer is used as a specific example in the following description of the paste base, but the paste base of the carbon dioxide external preparation of the present invention can be used without particular limitation as long as it gives alcohol a viscosity.
• the compounding amount of the carboxyvinyl polymer may be a compounding amount capable of being applied to the skin, cloth or the like in a paste form having viscosity and adhesiveness.
• the preferred blending amount of the carboxyvinyl polymer is approximately 0.1 to 40% by mass with respect to the total solid material of the carbon dioxide external preparation of the present invention.
• the carbon dioxide external preparation of the present invention may further contain a thickener.
• the thickener is a thickener other than the carboxyvinyl polymer (hereinafter also referred to as "additional thickener”), thereby reducing the relative content of the carboxyvinyl polymer, The stringing phenomenon peculiar to vinyl polymer is suppressed.
• additional thickeners which have a slower rate of dissolution or swelling in water than carboxyvinyl polymers, slows the rate of water absorption of the carbon dioxide external preparation, causing acidation with the carbonate, acid and / or hydrolysis.
• the additional thickener one or more selected from the group consisting of natural polymers, semi-synthetic polymers, synthetic polymers, and inorganic substances can be used.
• natural polymers include plant materials such as gum arabic, carrageenan, galactan, agar, quince seed, guar gum, tamarind gum, tragacanth gum, pectin, mannan, locust bean gum, rice starch, flour starch, corn starch and potato starch
• plant materials such as gum arabic, carrageenan, galactan, agar, quince seed, guar gum, tamarind gum, tragacanth gum, pectin, mannan, locust bean gum, rice starch, flour starch, corn starch and potato starch
• molecules such as curdlan, xanthan gum, succinoglucan, dextran, hyaluronic acid and pullulan
• protein polymers such as albumin, casein, collagen, gelatin and fibroin.
• Examples of synthetic polymers include sodium polyacrylate, polyvinyl acetal diethylaminoacetate, polyvinyl alcohol, polyvinyl pyrrolidone, methacrylic acid-ethyl acrylate copolymer, methacrylic acid-ethyl methacrylate copolymer, ethyl methacrylate / methacrylic acid
• Examples include trimethylammonium ethyl chloride copolymer, dimethylaminoethyl methacrylate / methyl methacrylate methacrylate copolymer and the like.
• the inorganic substance examples include hydrated silicon dioxide, light anhydrous silicic acid, colloidal alumina, bentonite, laponite, hectorite and the like.
• a thickener other than carboxyvinyl polymer hydroxypropyl cellulose, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, sodium polyacrylate, carrageenan, hydroxyethyl cellulose, xanthan gum and gellan gum are preferable.
• the compounding amount of the additional thickener is about 0.1 times to 50 times, preferably about 5 to 20 times, the mass of the carboxyvinyl polymer.
• the alcohol used for the external preparation for carbon dioxide of the present invention is not particularly limited as long as it is a liquid at normal temperature and can be used for the external preparation, and monohydric alcohols such as methanol, ethanol, n-propanol and isopropanol; Polypentyl alcohol such as pentyldiol, ethylene glycol, diethylene glycol, glycerin, diglycerin, 1,3-butylene glycol, 1,2-pentanediol, propanediol, propylene glycol, dipropylene glycol, hexylene glycol, polyethylene glycol, etc. And one or more of these can be used. Among these, polyhydric alcohols are preferred.
• the amount of alcohol added is such that the carbon dioxide external preparation of the present invention has a viscosity and adhesiveness that allows it to be applied to skin, cloth, etc., and a viscosity that does not precipitate alcohol-insoluble solid materials. Any amount may be used.
• the preferred blending amount of the alcohol is about 80 to 400% by mass with respect to the total solid material of the carbon dioxide external preparation of the present invention. In the carbon dioxide external preparation of the present invention, even if the alcohol-insoluble solid raw material slightly precipitates, the external preparation can be stirred at the time of use to disperse the precipitate throughout.
• the particle size is as small as possible and the specific gravity is the same or close.
• the alcohol is hygroscopic, and when the water content is a certain level or more, carbon dioxide may be generated during the production of the external preparation for carbon dioxide of the present invention.
• a drying method a known drying method suitable for the type of alcohol, such as using a molecular sieve or a desiccant such as calcium oxide, magnesium oxide, anhydrous potassium carbonate, anhydrous sodium sulfate, anhydrous magnesium sulfate, silica, zeolite, etc. Can be used.
• a desiccant can be further added to the carbon dioxide external preparation of the present invention. Since alcohol is hygroscopic, the carbonate contained in the carbon dioxide external preparation of the present invention and an acid and / or a substance capable of generating an acid by hydrolysis are dissolved by the water absorbed by the alcohol of the external preparation and used. Carbon dioxide may be generated before. Therefore, by adding a desiccant, carbon dioxide generation reaction can be prevented from occurring until water is supplied to the carbon dioxide external preparation.
• desiccant known desiccants that can be used for drying depending on the type of alcohol can be used, such as calcium oxide, magnesium oxide, anhydrous potassium carbonate, anhydrous sodium sulfate, anhydrous magnesium sulfate, silica, zeolite, etc. These may be used alone or in combination of two or more. Furthermore, it is also possible to use an anhydride of a carbonate, or an acid and / or an anhydride of a substance capable of generating an acid by hydrolysis as a desiccant. Of course, it can also be used in combination with the above-mentioned desiccant suitably.
• the carbonate used in the carbon dioxide external preparation of the present invention is not particularly limited as long as it reacts with an acid to generate carbon dioxide, and, for example, ammonium carbonate, ammonium hydrogencarbonate, potassium carbonate, potassium hydrogencarbonate, sesquicarbonate Examples thereof include potassium, sodium carbonate, sodium hydrogencarbonate, sodium sesquicarbonate, magnesium carbonate, magnesium hydrogencarbonate, calcium hydrogencarbonate and calcium carbonate, and one or more of these may be used.
• the preferred blending amount of carbonate is approximately 1 to 60% by mass with respect to the total amount of the solid raw material of the carbon dioxide external preparation of the present invention.
• the carbonate may be a delayed release particulate or the like, using conventional pharmaceutical means, to reduce the rate of reaction with the acid.
• the acid used for the external preparation for carbon dioxide of the present invention is not particularly limited as long as it generates carbon dioxide by reacting with a carbonate, and one or more selected from the group consisting of organic acids or inorganic acids Two or more can be used.
• organic acids include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, fumaric acid, maleic acid, dicarboxylic acids such as phthalic acid, isophthalic acid and terephthalic acid, and acids such as glutamic acid and aspartic acid Amino acid, glycolic acid, malic acid, tartaric acid, itatartaric acid, citric acid, isocitric acid, hydroxyacrylic acid, ⁇ -oxybutyric acid, glyceric acid, talthronic acid, salicylic acid, gallic acid, lactic acid, tropic acid, ascorbic acid, gluconic acid, etc.
• an inorganic acid for example, phosphoric acid, potassium dihydrogenphosphate, sodium dihydrogenphosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium acid hexametaphosphate, sodium acid pyrophosphate And potassium acid pyrophosphate and sulfamic acid, and one or more of these may be used.
• the compounding amount of the acid is an amount capable of neutralizing, preferably, all of the carbonate of the carbon dioxide external preparation of the present invention.
• slow release granules and the like may be used using conventional pharmaceutical means in order to reduce the reaction rate with carbonates.
• Substances that generate an acid by hydrolysis which are used for the external preparation for carbon dioxide of the present invention, include lactones such as glucono delta lactone and pantolactone, D, L- or L-lactide (3,6-dimethyl-1,4 Cyclic dimers of organic acids such as -dioxane-2,5 dione), D, L- or L-glycolide, and acid anhydrides such as phthalic anhydride, maleic anhydride and succinic anhydride, etc. One or more of these may be used.
• the substance that generates an acid by hydrolysis has a small amount of acid generated at the initial stage of dissolution in water, so the amount of carbon dioxide generated when water is supplied to the carbon dioxide external preparation of the present invention uses an acid There may be less in comparison with the case.
• the amount of carbon dioxide generated from the initial stage of supplying water to the carbon dioxide external preparation of the present invention can be made to be a certain amount or more, and the generation of carbon dioxide can be sustained.
• the compounding amount of the substance capable of generating an acid by hydrolysis is an amount capable of preferably neutralizing a part of the carbonate used in the carbon dioxide external preparation of the present invention.
• the substance that generates an acid by hydrolysis to suppress the reaction rate with the carbonate may be a delayed release particulate or the like using a conventional pharmaceutical method.
• a water soluble excipient can be further added.
• carbon dioxide is generated by the reaction of an acid and a carbonate, but this reaction requires water, and when the carbon dioxide external preparation of the present invention contains a water-soluble excipient, the external application The amount of water absorbed by the agent is large, the reaction of carbon dioxide generation tends to occur, and the amount of carbon dioxide generated increases.
• water-soluble excipient those having the solubility defined in “soluble” or “very soluble” described in 15th revision Japanese Pharmacopoeia are preferable.
• monosaccharides such as arabinose, galactose, glucose, xylose, sorbose, fructose, mannose, ribose, rhamnose, disaccharides such as sucrose, cellobiose, trehalose, maltose, lactulose, lactose, arabitol, erythritol, xylitol, sorbitol And sugar alcohols such as maltitol, mannitol and the like, and one or more of these may be used.
• a heat generating agent can be further added.
• carbon dioxide is generated by the reaction of carbonate and acid in the presence of water, but this reaction is an endothermic reaction, and when the amount of water is large, the temperature of the carbon dioxide external preparation is lowered, and the skin is The skin temperature may be lowered at the time of application, and the blood flow increasing action by the percutaneous absorption of carbon dioxide may be impeded.
• Exothermic agents can ameliorate this problem.
• the heat generating agent for example, one that generates heat of hydration when dissolved in water, such as calcium chloride can be used.
• the compounding amount of the heat generating agent can be easily determined from the amount of water when using the carbon dioxide external preparation of the present invention, the calorific value per mass of the heat generating agent, and the water temperature to be increased. That is, if the amount of water supplied to the external preparation for carbon dioxide of the present invention is 5 g and it is desired to raise the water temperature by 5 degrees, when the heat generating agent is calcium chloride, theoretically 123 mg of calcium chloride is used for the external preparation for carbon dioxide It should be blended. Although the blending amount of the heat generating agent can be arbitrarily selected, it is preferably 5 to 30% by mass with respect to the total amount of solid substances of the carbon dioxide external preparation.
• the carbon dioxide external preparation of the present invention generates carbon dioxide to become a viscous carbon dioxide external preparation when dissolved or swollen with an appropriate amount of water. When the amount of water is large, it becomes a viscous aqueous solution having a low viscosity, which is not preferable because the dissipation of carbon dioxide increases.
• the mixing ratio of the carbon dioxide external preparation of the present invention to water is generally 0.1 to 40 parts by mass, preferably 0.5 to 10 parts by mass, with respect to 1 part by mass of the carbon dioxide external preparation.
• the carbon dioxide external preparation of the present invention When the carbon dioxide external preparation of the present invention is directly applied to a moist wound surface, water is supplied from the wound surface exudate or the like to the external preparation, so that it is not necessary to separately supply water. Similarly, it is not necessary to separately supply water only to direct application of the external preparation for carbon dioxide of the present invention to organs and organs with a large amount of water such as the oral cavity and large intestine. Of course, also in such usage, the amount of carbon dioxide generated can be increased by separately supplying water.
• a preferred embodiment of the carbon dioxide external preparation of the present invention is a paste-based carboxyvinyl polymer, malic acid as an acid and / or tartaric acid, and sodium dihydrogen phosphate, alcohol as an alcohol 1,3-butylene glycol, propylene glycol, One or more dihydric or trihydric alcohols selected from glycerin, hydroxypropyl cellulose, hydroxypropyl methylcellulose, carrageenan, sodium alginate and sodium carboxymethylcellulose as additional thickeners And optionally sodium sulfate as a desiccant.
• the carbon dioxide external preparation of the present invention can be coated on a carrier and used as a sheet agent.
• the carrier When the carrier has water retention, it is preferable to include water in the carrier because the amount of carbon dioxide generated is increased rather than simply attaching the sheet agent to the target site.
• the water-retentive carrier include woven fabric, non-woven fabric, sponge and the like, and one or more of these may be used.
• the external preparation for carbon dioxide of the present invention absorbs water in the large intestine to generate carbon dioxide by being injected into the large intestine, treatment and prevention of hemorrhoids and treatment of constipation due to a decrease in feces reflex function Is possible.
• Examples 1 to 74 As shown in Table 1-6, carbonates, acids and / or substances that generate acids by hydrolysis (acids or their substitutes), alcohols, carboxyvinyl polymers (base), and, optionally, carboxyvinyl polymers Prepared a carbon dioxide external preparation by another method using another thickener (additional thickener), a water-soluble excipient and a desiccant.
• the numbers in the table indicate parts by mass of each raw material.
• As the alcohol, reagents and the like were used as they were unless otherwise specified.
• the alcohol used after drying is indicated in italic letters.
• Test Example 2 Comparison with Prior Art According to Example 11 of Patent Document 9, 1.5 g of sodium hydrogen carbonate, 50 mg of phenoxyethanol, 1.5 g of anhydrous citric acid, 100 mg of hydroxypropyl methylcellulose, and 6.85 g of 1,3-butylene glycol An effervescent skin cosmetic was prepared in a 50 ml glass beaker. In addition, although it prepared in total 3 times using hydroxypropyl methylcellulose from which a production lot differs, respectively, the viscosities of the obtained foamable skin cosmetics were inadequate, and the solid raw material precipitated at the bottom of the beaker.
• the strength of the vasodilator action is proportional to the strength of the skin redness in the same subject, the degree of the redness of the example and the carbon dioxide gas pack agent Ecotwo Gel Bcy (manufactured by Kosmepro) is visually compared and evaluated. did.
• 0.2 g of the carbon dioxide external preparation of the present invention is applied to the back of the left hand in an area of 4 cm square, and 4 cm square cut cotton containing about 2 g of purified water is immediately placed thereon.
• the degree of skin redness and durability under the external preparation were visually evaluated by a single examiner (male 62-year-old) according to the following evaluation criteria.
• a carbon dioxide gas pack agent Ecotwo Gel Bic manufactured by Cosmepro
• 1 g of the preparation was applied to the back of the right hand in an area of 4 cm square.
• Test example 4 Muscle fatigue recovery test
• the effects of muscle training and recovery from muscle fatigue are known by percutaneous absorption of carbon dioxide (Japanese Orthopedic Association Journal, 88: 34-39 2014).
• Test Example 4 it was examined whether or not the decrease in grip strength due to muscle fatigue was recovered by the carbon dioxide external preparation of the present invention.
• the study was conducted by an orthopedic specialist at an orthopedic clinic.
• the grip strength of both hands was measured with a digital grip strength meter for six male subjects. In general, it is easier for the hand to exert strength in grip. Therefore, in order to measure the effect of the carbon dioxide external preparation of the present invention more correctly, it was decided to use the carbon dioxide external preparation to a non-dominant hand.
• One g of the carbon dioxide external preparation of Example 65 was applied to the entire forearm of the non-dominant hand, and after resting for 10 minutes, the grip strength of both hands was measured. Since muscle fatigue is caused by the initial grip measurement, grip strength is usually reduced when grip strength is measured again after 10 minutes of measurement. If muscle fatigue is recovered or muscle strength is enhanced by the carbon dioxide external preparation of the present invention, the grip strength of the non-dominant hand used is lower than the grip strength of the dominant hand not using the carbon dioxide external preparation of the present invention. It is expected to be small or increase. For example, if the grip strength of the dominant hand is reduced by 1 kg due to muscle fatigue, the increase or decrease is -1 kg.
• the external preparation of carbon dioxide of the present invention is as follows, assuming that the muscle strength recovery ability of the left and right hands is almost the same in each subject. In the same subject, the grip strength increase or decrease -1 kg was changed to +1 kg, so it can be estimated that the degree of recovery from muscle fatigue is +2 kg. Therefore, the recovery grip in this test was defined as follows. In this test, those with a recovery grip of +0.5 kg or more by the carbon dioxide external preparation of the present invention were evaluated as effective, and those with +0.5 kg or less as ineffective. The results are shown in Table 10.
• the grip strength of the dominant hand was reduced or almost unchanged in the grip measurement after 10 minutes due to muscle fatigue by the first grip measurement.
• the decrease in grip strength of the non-dominant hand applied with the carbon dioxide external preparation of the present invention was small or increased in five subjects, so that the muscle fatigue recovery effect by the carbon dioxide external preparation of the present invention is clear Met.
• Test example 5 joint contracture improvement test
• the study was conducted by a physical therapist.
• the subject is a 78-year-old woman with spastic muscles in the lower leg of stroke hemiplegia. There was no improvement in symptoms due to regular rehabilitation, contracture was strong, and walking was impaired.
• 1 g of the carbon dioxide external preparation of Example 61 was applied to the lower thigh, the dorsiflexion angle of the ankle joint was improved by 5 to 10 degrees after approximately 10 minutes, and the walking became easy, so that the carbon dioxide external preparation of the present invention
• Test Example 6 Pain reduction test
• the study was conducted by a physical therapist.
• the subject was a 58-year-old woman with Dukelban syndrome in whom the oral anti-inflammatory agent loxoprofen sodium was ineffective for pain.
• 0.5 g of the carbon dioxide external preparation of Example 64 was applied to the target site, the pain almost disappeared after about 10 minutes, so that the pain alleviating effect of the carbon dioxide external preparation of the present invention was clear.
• Test Example 7 Pain reduction test
• the study was conducted by a physical therapist.
• the subject has pain during pitching around the latissimus muscle in the right subscapular angle, a 16-year-old male baseball pitcher who was ineffective for pain with diclofenac sodium ointment.
• the carbon dioxide external preparation of Example 64 was applied to the target site, the pain almost disappeared after approximately 10 minutes, and the throwing was able to be performed with full strength; therefore, the pain due to the carbon dioxide external preparation of the present invention
• the mitigation effect was clear.
• the carbon dioxide external preparation of the present invention has a large amount of percutaneous absorption of carbon dioxide, and generation of carbon dioxide is sustained only by applying to the skin or by supplying water further. It is clear that an excellent carbon dioxide external preparation can be obtained.
• Test Example 8 (ganglion treatment test) The study was conducted by an athletic trainer. The subject was a 20-year-old male gymnast with a ganglion with a diameter of about 1 cm and a height of about 4 mm in front of the right ankle. When 0.1 g of the carbon dioxide external preparation of Example 73 was applied to the ganglion and its surrounding skin once a day for 1 week, the ganglion disappeared completely, so that the ganglioside treatment effect of the carbon dioxide external preparation of the present invention was It was clear.
• Test example 9 (rheumatic pain and knee stiffness improvement test)
• the subject is a woman in her 80s who did not improve knee stiffness and pain due to rheumatism with the oral anti-inflammatory agent loxoprofen sodium etc.
• 0.1 g of the carbon dioxide external preparation of Example 73 was applied to the skin of the knee once a day, the pain in the knee did not wake up in the night after 2-3 days and walking was facilitated, The rheumatic pain and knee stiffness improving effect of the external carbon dioxide preparation of the present invention was clear.
• Test Example 10 (pigmentation improvement test) The subject is a female in her 40s who has performed hair removal on her pubic area at a medical institution and has brown pigmentation on the hair removal area.
• 0.1 g of the carbon dioxide external preparation of Example 72 was applied to the pigmented part once a day, pigmentation was observed one week after no effect was usually observed with the anti-inflammatory agent etc. taken by the subject. Since it disappeared, the pigmentation improvement effect by the carbon dioxide external preparation of the present invention was clear.
• the carbon dioxide external preparation of the present invention comprises a paste base, an alcohol, a carbonate, an acid and / or a substance capable of generating an acid by hydrolysis, which is applied to the skin only, or further supplied with water. It is useful because carbon dioxide-specific effects can be obtained.

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