WO2018236109A1 - Cosmetic composition for improving moisture of hair, containing mixture of arginine, hyaluronic acid, and macadamia nut oil - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving the moisture of hair, containing a mixture of arginine, hyaluronic acid and macadamia nut oil and, more specifically, to a cosmetic composition for improving the moisture of hair, containing, as an active ingredient, a mixture of arginine, hyaluronic acid and macadamia nut oil, which increase the internal water content of hair (especially damaged hair). A cosmetic composition, according to the present invention, for improving the moisture of hair, preferably damaged hair, containing, as an active ingredient, a mixture of arginine, hyaluronic acid and macadamia nut oil exhibits effects of improving the ability to maintain the internal water of hair and increasing the period of water retention of hair by increasing the internal water content of hair and inhibiting the evaporation of the internal water of hair.

Description

A cosmetic composition for improving the moisturizing power of hair containing a mixture of arginine, hyaluronic acid and macadamia nut oil

The present invention relates to a cosmetic composition for improving the moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil, and more particularly to a cosmetic composition for improving the moisture resistance of arginine, hyaluronic acid, and macadamia nut oil which increases the water content of hair The present invention relates to a cosmetic composition for improving the moisturizing power of hair containing a mixture of nut oil as an active ingredient.

Hair does not have a direct relationship with life, but it has the functions of protecting the body, keeping warm and touching, acting as a cushion against external friction, and protecting the hair from direct sunlight, cold and heat. .

In particular, eyebrows, eyelashes, nose hair, and ear hair among the hair have a function to protect against invasion of sweat, dust and worms, and have the function of absorbing heavy metals such as mercury, arsenic and lead unnecessary to the body and discharging them out of the body.

In addition, hair plays an important role in showing the characteristics of male and female in decorative aspect. Even if the same person changes the color of hair and hair, another impression can be made. Thus, the hair not only protects the tofu, but also plays a decorative role.

Hair is a thin and thin protein structure with an average thickness of about 0.07 mm. It can be roughly classified into a hair shaft that goes outside the skin and a hair root inside the skin. The scalp has a basic structure and physiological functions similar to the skin, and the hair follicle is more complex than the other parts and has many sebaceous glands. The hair follicle part is the part inside the hair follicle which is buried in the scalp and the depth is about 2-4mm. The bottom part of the root is bulge like a bead, and this part is called a hair bulb, and the thickness of the hair is determined by the size of this part.

The enlarged section of the hair is divided into three parts: Medulla, which is the innermost part and the center, Cortex, which surrounds the water quality, and Cuticle, which is the outer part of the hair. The skin coat covers the surface of the hair and has a strong chemical resistance surrounding the inside of hair. It consists of three layers from the outside called Epicuticle, Exocuticle and Endocuticle. The follicle is located in the inner part of the eye patch and occupies the majority (85 ~ 90%) of the hair. The main component is keratin protein and consists of cortical cells and intercellular binding material. . The quality of the water exists in the center of the hair, it has some melanin pigment particles, and the water contains air because it has many big and small fears.

Hair is damaged by friction, heat, physical cutting, perm, decolorization, dyeing, sunlight and the like. First, hair damage caused by heat is caused by the heat generated by the dryer when drying after hair washing, the water is evaporated and dried, the hair is expanded and deformed, and the black hair is turned into a dark brown color. Also, bubbles start to form during the fur and quality of the hair, and the hair is no longer elastic and the skin becomes melted.

Second, hair damage caused by perm is caused by defective treatment of perm solution, lack of time, and when hair becomes weak, alkali remains in hair, or oxidant remains, it causes keratin protein denaturation and fading of melanin pigment.

Third, oxidative decolorizing effect of melanin pigment due to hydrogen peroxide occurs in addition to alkaline agent as a decolorizing agent. Repeated exposure to decolorant in the short term may cause hair to break due to repeated softening of swelling or twisting of the skin.

Finally, the ultraviolet rays and ultraviolet rays of the sunlight damage the hair keratin protein or cause protein denaturation.

As a result, modern people have been suffering a lot of hair damage due to permer, dry and dyeing, and frequent hair loss due to various cleaning agents and air pollution can not be avoided. However, despite many efforts to restore damaged hair to its original healthy state with frequent chemical treatment and hair loss, the results were small. Unlike other biomedical tissues, hair is a dead tissue, so there is a limit to the use of damaged parts.

For example, a hair conditioner has been mainly used to prevent or improve the damage of such hair. Hair conditioners mainly contain long-chain quaternary ammonium compounds and higher fatty alcohols, hydrocarbon oils and silicone oils. The long-chain quaternary ammonium cation surfactant and the high-grade fatty alcohol and the hydrocarbon oil provide hair gloss, moisturizing and softness. The silicone oil is artificially used to reduce the stiffness of the hair due to removal of sebum after shampooing It is used to impart softness and shine to hair by imparting a feeling similar to sebum.

Moisturization of the hair is caused by the moisture inside the hair and the moisture on the surface of the hair. The flexibility of the hair is determined by the moisture inside the hair, and the degree of moistness is determined by the moisture on the surface of the hair. However, since the moisture contained in the hair is in equilibrium with the outside of the hair, it is greatly affected by the external environment, that is, temperature, humidity, ultraviolet rays, and the like. Therefore, not only the initial moisture content, but also the effective preservation of the moisture contained in the hair, the hair becomes dry and rough and rough.

The hair has an average moisture content of around 20% at room temperature (25 ° C, 1 atm), and the moisture content varies from 3 to 34% depending on the relative humidity of the hair. Due to the structural specificity of the hair consisting of lipid layer made of lipid and cuticle mainly composed of protein on the cuticle surface, the water present in the hair is present in the hair in a form having two physical properties (C Barba, et al. , Thermochimica Acta , 494: 136-140, 2009). It is divided into external water and internal water. The external moisture is non-covalent bond that evaporates when heated at 65 ℃ for 40 minutes. It is mainly water on the surface of hair. The water content is 20 minutes at 180 ℃ It is moisture that stably exists through ionic bonding with the amino acid of the hair constituent protein which evaporates at the time of heating.

In order to understand the characteristics of hair moisture and to effectively and intrinsically moisturize the hair that has been dried by decolorization and styling and environmental (UV, fine dust) damage, It is necessary to develop a composition which improves the elasticity, softness and calmness of the hair through the improvement of the moisturizing power of the inner and outer moisture of the hair and removes the dry hair discomfort of the customer.

Most conventional moisturizing methods are to moisturize the inside of the hair using a substance having a high affinity for water such as a protein or a protein derivative and then use a moisturizer, ) And the like. However, this method maintains the moisture of the hair to a certain extent, but since it is impossible to prevent the complete water evaporation, the moisture inside the hair is still in equilibrium with the external moisture. Therefore, it is affected by the external environment such as temperature, humidity, and ultraviolet ray, which makes hair moisturizing effective.

Macadamia Nut Oil (Macadamia Nut Oil, Macadamia Ternifolia Seed Oil) is a vegetable oil extracted from fruit of macadamia harvested from Australia, Hawaii, Brazil, South Africa and Israel. It is colorless or light yellow, odorless, , And more than 80% of the total weight is composed of monounsaturated fatty acids.

Oleic acid, which is the main component of macadamia nut oil, has skin aging activity. Palmitoleic acid, which accounts for about 20% by weight of macadamia nut oil, is also found in animals, Is the essential component of Sebum.

Palmitoleic acid, which accounts for about 22% by weight of the lipid content of human skin, together with palmitic acid, accounts for about half of the skin lipid, and has the lubrication, softening, And the like.

In particular, palmitoleic acid has excellent spreadability and penetration ability as a carrier and softening agent, and it has excellent absorbency, leaving a soft and non-sticky feeling when applied to the skin. It acts very smoothly on the skin to prevent aging of the skin, Protects skin from free radicals. Palmitoleic acid is a supplement for palmitoleic acid in the skin, which is reduced in skin aging. It can be used as cosmetic formulations such as cream, helps to maintain the skin's lipid mantle, smoothes the skin and absorbs the skin It can also be used for body massage, it fits all skin types and is especially suitable for dry skin, skin elasticity and moisturizing skin.

The cosmetic composition containing macadamia nut oil is not limited in its formulation, but may contain various components that are formulated in ordinary cosmetic compositions according to various formulations or for the final purpose. As a cosmetic formulation, an emollient containing about 5 to 10% by weight of macadamia nut oil can be used as an anti-aging supplement or as a sunscreen agent and can contain about 2 to 10% by weight of macadamia nut oil The macadamia nut oil can be used as a baby oil or a massage oil in an amount of 100% by weight, and macadamia nut oil can be used as a lipstick formulation containing essential oil of aromatherapy. It can also be used as a carrier and Macadamia nut oil can also be used as an alternative to mineral or jojoba oil in creams or lotions.

Under these technical backgrounds, the inventors of the present invention have found that a cosmetic composition for improving hair moisturizing ability capable of maintaining high flexibility and moistness for a long time by keeping hair moisturized continuously without being affected by external environment such as temperature, humidity or ultraviolet rays A cosmetic composition for improving the moisturizing power of hair containing a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient has been found to be effective for increasing the water content of the hair and inhibiting evaporation of the water of the hair, It is possible to obtain an effect of enhancing the retention of water and increasing the maintenance period of the quick water of the hair, thus completing the present invention.

It is an object of the present invention to provide a cosmetic composition for improving the moisturizing power of hair containing a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient.

Another object of the present invention is to provide a cosmetic composition for improving the moisturizing power of damaged hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient.

It is still another object of the present invention to provide a cosmetic product made from the cosmetic composition.

In order to attain the above object, the present invention provides a cosmetic composition for improving the moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient, and preferably a cosmetic composition for improving the moisturizing power of damaged hair.

The present invention also provides cosmetics manufactured from the cosmetic composition.

The present invention also provides use of a mixture of arginine, hyaluronic acid and macadamia nut oil as a hair moisturizing agent in the production of cosmetic compositions or cosmetics for improving the moisture resistance of hair.

The cosmetic composition for improving the moisture retention (moisture retention) of hair, preferably damaged hair, comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient according to the present invention is effective for increasing the water content of the hair, It has an effect of increasing the holding power of the hair moisture by the inhibition of evaporation and increasing the holding period of the hair moisture.

Figure 1 shows the change in moisture content in hair of damaged dry hair treated with arginine or hyaluronic acid (Graph: Mean ± standard error of measurement (SEM)).

Fig. 2 shows changes in the moisture content of the hair of damaged hair treated with free fatty acids (Graph: Mean ± standard error of measurement (SEM)).

Fig. 3 shows the change in the moisture content of the hair of damaged dry hair treated with Macadamia nut oil (Graph: Mean ± standard error of measurement (SEM)).

Figure 4 shows the change in moisture content in hair of damaged dry hair treated with a mixture of arginine, hyaluronic acid and macadamia nut oil (Graph: Mean ± standard error of measurement (SEM)).

Figure 5 shows the change in moisture content in hair of damaged dry hair treated with one or more of arginine, hyaluronic acid and macadamia nut oil (Graph: Mean ± standard error of measurement (SEM)).

Figure 6 shows the change in hair moisture content of damaged dry hair treated with one or more of arginine, hyaluronic acid and macadamia nut oil (Graph: Mean ± standard error of measurement (SEM)).

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is well known and commonly used in the art.

The term " about " used herein to refer to concentration, volume, or weight means that there is a maximum tolerance of 10% in that numerical or numerical range.

In one embodiment of the present invention, arginine or hyaluronic acid was treated with arginine or hyaluronic acid to examine the effect of increasing the moisture content of arginine or hyaluronic acid. As a result, as shown in Fig. 1 and Table 1, it was confirmed that arginine or hyaluronic acid has an effect of increasing the fast water content of hair at an appropriate effective content, and particularly, arginine is treated at 100 ppm or more, hyaluronic acid is at least 1000 ppm In damaged dry hair treated, the water content of the hair increased statistically significantly compared to the control (untreated damaged dry hair) (see Test Example 1).

In another embodiment of the present invention, in order to confirm the effect of increasing the surface moisture content of the free fatty acid, the damaged hair was treated with free fatty acid and then the change in the moisture content of the hair was confirmed. As a result, as shown in FIG. 2 and Table 2, it was confirmed that palmitoleic acid had an effect of significantly increasing the surface moisture content of the hair at an appropriate effective amount, and in particular, the control (untreated damaged hair) And the water content was increased (see Test Example 2).

In another embodiment of the present invention, a macadamia nut which contains a high content of palmitoleic acid (cis-9-hexadecenoic, 16: 1 (n-7); molecular weight of 254.4 Da; In order to confirm the effect of increasing the moisture content of the oil, damaged dry hair was treated with macadamia nut oil and the change in the moisture content of the hair was confirmed. As a result, as shown in FIG. 3 and Table 4, it was confirmed that macadamia nut oil had an effect of increasing the surface moisture content of the hair at an appropriate effective amount. In particular, in damaged dry hair treated with macadamia nut oil at 10 ppm or more, The hair moisture was increased statistically significantly compared to the untreated damaged hair. On the other hand, as shown in Table 4, even when macadamia nut oil having a final concentration of 10 ppm, 100 ppm, 1,000 ppm, or 10,000 ppm was treated on damaged dry hair, there was almost no change in the water content of hair (see Test Example 3).

In addition to macadamia oil (19.3 wt%), vegetable oils containing palmitoleic acid in a high content also contained avocado oil (7.5 wt%), olive oil (2.5 wt%), coconut oil (1.5 wt% Jatropha (1.5% by weight), almond oil (1.0% by weight). (Jang et al., J Plant Biotechnol , 37: 25-46, 2010), avocado oil, olive oil, coconut oil, coral fluid oil and almond oil. A palmitoleic acid-rich oil, such as jojoba oil, may be applied to the mixture of the present invention as an alternative to, or as a supplement to, macadamia nut oil.

In another embodiment of the present invention, a mixture of arginine, hyaluronic acid and macadamia nut oil is treated with a mixture of arginine, hyaluronic acid and macadamia nut oil in damaged dry hair to ascertain the effect of increasing the moisture content in the hair of the hair treated with arginine, hyaluronic acid and macadamia nut oil , And then the change in moisture content in the hair was confirmed. As a result, as shown in Fig. 4 and Table 5, it was confirmed that a mixture of arginine, hyaluronic acid and macadamia nut oil had an effect of increasing the fast water content of hair at a proper effective content. Especially, the mixture was arginine, hyaluronic acid And macadamia nut oil were mixed at an equivalent ppm concentration, a synergistic effect of increasing the fast water content of the hair was found to be statistically significant when a mixture of 100 ppm of arginine, 1000 ppm of hyaluronic acid and 10 ppm of macadamia nut oil was used . In addition, as shown in Fig. 5 and Table 6, a mixture of arginine, hyaluronic acid and macadamia nut oil has a synergistic effect of increasing the fast water content of hair statistically significantly more than a mixture of arginine and hyaluronic acid (See Test Example 4).

In another embodiment of the present invention, in order to confirm the efficacy of increasing the hair moisture content of hair treated with at least one of arginine, hyaluronic acid and macadamia nut oil, at least one of arginine, hyaluronic acid and macadamia nut oil , And then the change in the moisture content of the hair was confirmed. As a result, as shown in FIG. 6 and Table 6, it was confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil has an effect of increasing the surface moisture content of hair at a proper effective content, and in particular, arginine, hyaluronic acid and macadamia nut Oil mixture was found to have a synergistic effect of increasing the surface moisture of the hair statistically significantly higher than that of a mixture of arginine and hyaluronic acid (group 2) (see Test Example 5).

Accordingly, in one aspect, the present invention relates to a cosmetic composition for improving the moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient, and preferably a cosmetic composition for improving the moisturizing power of damaged hair.

The arginine (Arg) is an amino acid which is transparent in color at room temperature, exists in a liquid state, and is added to fragrance, hair conditioning agent, skin conditioner, etc., and is used in an amount of about 10 to 10,000 ppm About 0.001 to 1% by weight), preferably about 100 to 1,000 ppm (about 0.01 to 0.1% by weight).

The hyaluronic acid (Hyaluronan, HA) is a substance which is transparent in color at a room temperature, exists in a liquid state, added to a scalp protecting agent and a hair improving agent, and is used in a cosmetic composition of about 100 to 100,000 ppm About 0.01 to 10% by weight), preferably about 1,000 to 10,000 ppm (about 0.1 to 1% by weight).

The Macadamia Nut Oil is a substance which is transparent or yellow in color at room temperature and exists in a liquid state and is known to contain a large amount of palytoleic acid. It is preferable that the cosmetic composition according to the present invention contains about 1 to 1,000 ppm (about 0.0001 to 0.1% by weight), preferably about 10 to 100 ppm (about 0.001 to 0.01% by weight).

The mixture of arginine, hyaluronic acid and macadamia nut oil contained in the cosmetic composition according to the present invention is prepared by mixing arginine, hyaluronic acid and macadamia nut oil in an amount of 80 to 120: 800 to 1200: 8 to 12 (i.e., (I.e., 9 to 11: 90 to 110: 0.9 to 1.1), and most preferably 10: 1 to 12: 80 to 120: 0.8 to 1.2, more preferably 90 to 110: 900 to 1100: 100: 1. The mixture may be a mixture of arginine, hyaluronic acid and macadamia nut oil in a mixing ratio of ppm concentration and a corresponding weight ratio (% by weight).

In the present invention, considering the formulation stability of the cosmetic composition comprising a mixture of arginine, hyaluronic acid and macadamia nut oil and the limited use amount of the cosmetic process, the amount of arginine in the mixture is preferably in the range of the mixing ratio of arginine, hyaluronic acid and macadamia nut oil The total weight of the composition is maintained at 80 to 120: 800 to 1200: 8 to 12, more preferably 90 to 110: 900 to 1100: 9 to 11, most preferably 10: 100: (Arginine stock solution) is neutralized so as not to exceed 0.09% by weight, preferably 0.01 to 0.09% by weight, more preferably 0.01 to 0.05% by weight, based on the total weight of the cosmetic composition, And may be included in the composition. The amount of hyaluronic acid in the mixture is in the range of 80 to 120: 800 to 1200: 8 to 12, more preferably 90 to 110: 900 to 1100: 9 to 11, in terms of the mixing ratio (based on ppm concentration) of arginine, hyaluronic acid and macadamia nut oil By weight, preferably 0.1 to 0.9% by weight, more preferably 0.1 to 0.5% by weight, based on the total weight of the composition, while maintaining the weight ratio And the like. Macadamia nut oil in the mixture may contain an amount varying depending on the formulation of the composition, and the composition may be applied to wash-off wool formulations or leave-ons, The amount of macadamia nut oil is preferably 80 to 120: 800 to 1200: 8 to 12, more preferably 80 to 120: 800 to 1200: 2000, based on the mixing ratio of arginine, hyaluronic acid and macadamia nut oil (ppm concentration) , Preferably 0.001 to 0.009% by weight, more preferably 0.001 to 0.009% by weight, based on the total weight of the composition, while maintaining the weight ratio of the composition in the range of 90 to 110: 900 to 1100: 9 to 11, most preferably 10: 100: Preferably 0.001 to 0.005% by weight, based on the total weight of the composition.

In the present invention, when the content of the mixture is less than about 0.1 wt% (about 1,000 ppm) based on the total weight of the cosmetic composition, the hair moisturizing effect is insignificant, and when the content exceeds about 1.0 wt% (about 10,000 ppm) (1,000 to 10,000 ppm), preferably 0.1 to 0.5% by weight (1,000 to 5,000 ppm) based on the total weight of the composition, and more preferably, (1,000 to 2,000 ppm), and most preferably 0.111 wt% (1,110 ppm).

In the present invention, the composition may be characterized by increasing the external water content of hair, preferably damaged hair.

In the present invention, the composition may be characterized by increasing the internal water content of hair, preferably damaged hair.

In the present invention, the damaged hair is caused by one or more chemical treatments selected from the group consisting of dyeing and perming, physical damage, stress or nutritional deficiency.

The surface moisture content of the hair accounts for about 75% of the moisture content of the hair and can vary greatly depending on the relative humidity (RH), pH, temperature, etc. of the environment in which the hair is exposed.

The surface moisture of the hair mainly exists in the hair cell cuticle CMC (Cell Membrane Complex), which is lost due to evaporation at a temperature of about 65 ° C or higher.

The water content of the hair accounts for about 25% of the moisture content of the hair, and there is little change in the moisture content within the range of the relative humidity (RH) 25 to 95% of the environment in which the hair is exposed.

The water of the hair is evaporated and lost at a temperature of about 180 ° C or more, and is present in a state of hydrogen bonding with an amino acid in the interlamellar space of the hair.

In the present invention, the composition may be characterized in that it is for suppressing the water vaporization of the damaged hair and improving the moisturizing power.

In the present invention, the damaged hair may be caused by one or more chemical treatments selected from the group consisting of dyeing and perming, physical damage, stress, or malnutrition, but the present invention is not limited thereto.

In the present invention, the cosmetic composition of the present invention is not particularly limited in its formulation, but it may be formulated into ointments, hair lotions, hair rinses, hair treatments, scalp treatments, hair shampoos, , Pomade, and the like. The cosmetic composition of each of these formulations may contain various components that are formulated in a conventional cosmetic composition according to the above-described various formulations or for a final purpose, and the kind and amount of these components can be easily selected by those skilled in the art.

In the present invention, the cosmetic composition may be blended with other ingredients usually added to cosmetics. In this case, the compounding ingredient may be a preservative, a moisturizer, an emollient, a surfactant, an organic or inorganic pigment, an organic powder, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a plant extract, a pH adjuster, , A cold agent, an antiperspirant agent, purified water, etc. may be used.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.

Test Example  1: of hair Moisture content  Assessment of moisturizing power of hair by arginine or hyaluronic acid according to measurement

Arginine or hyaluronic acid was treated with arginine or hyaluronic acid to examine the effect of increasing the water content in the hair, and the change in water content in the hair was confirmed by a TG assay (Thermogravimetric assay).

<Test Subject>

Normal hair : Standard hair, 10 cm long normal black hair (Tress, BM-B10, Beaulax, Japan).

Damaged dry hair : The normal hair was decolorized with decolorant (1: 2: 3: 1 mixed decolorant) for 30 minutes and then treated with shampoo (Amos shampoo, Amore) Damaged dry hair prepared by washing with water and drying (drying for 10 minutes while keeping the surface temperature of the hair below 50 ° C).

<Sample for Hair Treatment>

Hair treatment for Sample 1: stock solution arginine (arginine powder (a product of sale) to prepare by dissolving in water.) The final concentration of 10ppm (about 0.001% by weight) by using, 100ppm (0.01 wt%), 1,000ppm (about 0.1 Weight%) and 10,000 ppm (about 1 wt%).

For hair treatment Sample 2: hyaluronic acid stock solution (sodium hyaluronate [Sodium Hyaluronate Crosspolymer] (manufactured by Galaxy Bio) was dissolved in water to prepare) it was used to a final concentration of 10ppm (0.001 wt%), 100ppm (0.01% by weight) , 1,000 ppm (0.1 wt%), and 10,000 ppm (1 wt%).

Also water or an alkyl benzoate (Alkyl Benzoate (four Bodum ^TM) treatment on the hair tested at a dose of 100μl: control group.

<Hair treatment method>

Arginine (sample 1 for hair treatment) or hyaluronic acid (sample 2 for hair treatment) was applied (treated) to damaged hair (see Test Subjects) at a concentration of 10 ppm, 100 ppm, 1,000 ppm or 10,000 ppm, The exposure to external air was minimized by placing it in a pouch (see Table 1 below for treatment concentrations of samples for hair treatment on subjects).

<Method for measuring hair moisture resistance: TG assay (Thermogravimetric assay)>

The moisture content of hair (untreated normal hair; untreated damaged dry hair; damaged dry hair treated with arginine or hyaluronic acid) was measured using a moisture analyzer (MS-70, A & D, Japan) (Triplicate samples) to determine the average value. At this time, the moisture content of the hair was measured by heating in two steps of 65 ° C (program 5) and 180 ° C (program 3), and the moisture content of the hair was measured in the range of 3 ~ The cumulative moisture evaporation (% (w / w)) for 30 minutes was measured (C. Barba, et al. , Thermochimica Acta , 494: 136-140, 2009; Yash Kamath, et. al., J. Cosmet . Sci . , &Lt; / RTI &gt; 65: 37-48, 2014; See, for example, Clarence R. Robbins, Chemical and Physical Behavior of Human Hair , Chapter 2.10 "Water: A Fundamental Component of Human Hair", 5th Edition, 2010).

Table 1 below shows the results of Tg assay (thermogravimetric assay) for the changes in the surface water content and the water content of hair caused by treatment with arginine or hyaluronic acid.

Test subject	For hair treatment Name of sample	Processing capacity	Surface moisture  medium (65 ° C, % )	Fast water  medium (180 DEG C, % )
Normal Hair (Healthy Hair)	No treatment	-	7.950	14.190
Damaged dry hair	No treatment	-	8.260	8.510
Damaged dry hair	Solvent (water)	100 μL	14.030	8.870
Damaged dry hair	Arginine	10ppm	14.420	9.740
Damaged dry hair	Arginine	100ppm	14.330	10.080
Damaged dry hair	Arginine	1,000ppm	16.960	10.840
Damaged dry hair	Arginine	10,000ppm	13.900	11.760
Damaged dry hair	Hyaluronic acid	10ppm	13.050	9.360
Damaged dry hair	Hyaluronic acid	100ppm	13.140	10.410
Damaged dry hair	Hyaluronic acid	1,000ppm	15.650	11.910
Damaged dry hair	Hyaluronic acid	10,000ppm	16.370	13.810

As a result, as shown in Fig. 1 and Table 1, it was confirmed that arginine or hyaluronic acid has an effect of increasing the fast water content of hair at an appropriate effective content, and particularly, arginine is treated at 100 ppm or more, hyaluronic acid is at least 1000 ppm In damaged dry hair treated, there was a statistically significant increase in the water content of the hair compared to the control (untreated damaged hair).

Test Example  2: of the hair Surface water content  Measurement of free fatty acid-induced hair Moisture power  Evaluation of improvement efficacy

In order to confirm the effect of increasing the moisture content of the hair by the free fatty acid, different kinds of free fatty acids were treated on the damaged hair, and then the change in the moisture content of the hair was confirmed by the TG assay (see Test Example 1) (control group: Alkyl Benzoate (four Bodum ^TM)).

Table 2 shows changes in the surface moisture and water content of the hair following treatment with the free fatty acid by means of a thermogravimetric assay (obtaining the average value by measuring the water content of three samples per each sample).

Test subject	For hair treatment Name of sample	Surface moisture  Average value (65 ° C,%)	Fast water  Average value (180 DEG C,%)
Normal Hair (Healthy Hair)	No treatment	13.570	10.880
Damaged dry hair	No treatment	6.610	9.930
Damaged dry hair	Solvent (alkylbenzoate)	11.070	7.690
Damaged dry hair	Palmitoleic acid (C16: 1)	19.110	7.800
Damaged dry hair	Linoleic acid (C18: 2)	10.910	8.890
Damaged dry hair	Erucic acid (C22: 1)	10.410	13.360
Damaged dry hair	Nervonic acid (C24: 1)	11.670	9.870

As a result, as shown in FIG. 2 and Table 2, it was confirmed that palmitoleic acid had an effect of significantly increasing the surface moisture content of the hair at an appropriate effective amount, and in particular, the control (untreated damaged hair) The water content was increased.

Test Example  3: of hair Surface water content  Depending on measurement Macadamia  Assessment of moisturizing power of hair caused by nut oil

Macadamia nut oil containing palmitoleic acid in vegetable oil was treated with macadamia nut oil for damaged hair to check the effect of increasing the moisture content of the hair, and then the change in the moisture content of the hair was measured by a TG assay See Example 1) (control: Alkyl Benzoate (Sabometh ^TM )).

<Sample for Hair Treatment>

Sample 3 for treating hair Macadamia Nut Oil (Macadamia Nut Oil) Macadamia Integrifolia Seed Oil or Macadamia Ternifolia Seed Oil (ADM, B &amp; H) with Alkyl Benzoate (Macadamia Nut Oil) to the final concentration using a dissolving in Bodum ^TM) prepare) to be 10ppm (0.001 wt%), 100ppm (0.01 wt%), 1,000ppm (0.1 wt.%) and 10,000ppm (1% by weight) to the test subject hair Processed.

Here, the test subjects, the control group for hair treatment, the hair treatment method, and the method for measuring the hair moisture resistance were the same as those in Test Example 1.

Macadamia nut oil containing a high content of palmitoleic acid, which is a free fatty acid, was used as the vegetable oil contained in the hair treating sample 3 or a mixture of arginine, hyaluronic acid and vegetable oil described later.

The composition of the free fatty acids contained in the stock solution of macadamia nut oil used in the present invention (manufactured by B & H Tech) is shown in Table 3 below. The content of palmitoleic acid in the stock solution was 15.0 to 22.0% by weight.

Fatty acid name	Saturated / unsaturated fatty acids	Macadamia  Content in nut oil ( weight% )
Lauric Acid	C12: 0	<0.5
Myristic Acid	C14: 0	0.5 to 1.6
Palmitic Acid	C16: 0	7.0 to 9.5
Palmitoleic Acid	C16: 1	15.0 to 22.0
Stearic Acid	C18: 0	2.0 to 5.5
Oleic Acid	C18: 1	55.0 to 67.0
Linoleic Acid	C18: 2	1.0 to 5.0
Linolenic Acid	C18: 3	0.1 to 3.0
Arachidic Acid	C20: 0	1.5 to 3.0
Elcosenoic Acid	C20: 1	1.5 to 3.0
Behenic Acid	C22: 0	0.1 to 1.0

Table 4 shows changes in the surface moisture content and the water content of hair caused by processing of macadamia nut oil with a thermogravimetric assay (the average value is obtained by measuring the moisture content of three samples per each sample).

Test subject	For hair treatment Name of sample	Processing capacity	Surface moisture  medium (65 ° C, % )	Fast water  medium (180 DEG C, % )
Normal Hair (Healthy Hair)	No treatment	-	7.950	14.190
Damaged dry hair	No treatment	-	8.260	8.510
Damaged dry hair	Solvent (alkylbenzoate)	100 μL	9.010	7.930
Damaged dry hair	Macadamia nut oil	10ppm	11.840	7.660
Damaged dry hair	Macadamia nut oil	100ppm	12.360	8.040
Damaged dry hair	Macadamia nut oil	1,000ppm	13.080	8.860
Damaged dry hair	Macadamia nut oil	10,000ppm	13.510	8.160

As a result, as shown in FIG. 3 and Table 4, it was confirmed that macadamia nut oil had an effect of increasing the surface moisture content of the hair at an appropriate effective amount. In particular, in damaged dry hair treated with macadamia nut oil at 10 ppm or more, The hair moisture was increased statistically significantly compared to the untreated damaged hair.

On the other hand, as shown in Table 4, even if macadamia nut oil having a final concentration of 10 ppm, 100 ppm, 1,000 ppm, or 10,000 ppm was treated on damaged dry hair, there was almost no change in the water content of hair.

Test Example  4: Moisture content  Arginine, hyaluronic acid and Macadamia  Assessment of moisturizing power of hair by mixture of nut oil

In order to confirm the efficacy of increasing the hair moisture content of hair treated with at least one of arginine, hyaluronic acid and macadamia nut oil, damaged hair is treated with at least one of arginine, hyaluronic acid and macadamia nut oil, Was confirmed by a thermogravimetric assay (see Test Example 1). The concentrations of arginine, hyaluronic acid and macadamia nut oil used were the optimum concentrations determined in Test Examples 1 and 3.

Here, the test subject, the hair treatment control, the hair treatment method, and the method for measuring the hair moisturizing power are the same as those in Test Example 1, and the mixture of arginine, hyaluronic acid, and macadamia nut oil is the arginine stock solution used for the preparation of hair treatment samples, hyaluronic acid 1: 1: 1 (i.e., '10 ppm arginine + 10 ppm hyaluronic acid + 10 ppm hyaluronic acid) was used as a final mixing ratio (based on the concentration of ppm) of arginine, hyaluronic acid and macadamia nut oil using the undiluted solution and an undiluted macadamia nut oil (see Test Examples 1 and 3) 100 ppm Arginine + 100 ppm Hyaluronic acid + 100 ppm Macadamia Nut Oil 'sample,' 1000 ppm Arginine + 1,000 ppm hyaluronic acid + 1,000 ppm Macadamia nut oil 'sample), 10: 10: 100 ppm arginine + 100 ppm hyaluronic acid + 10 ppm macadamia nut oil 'sample) and 10: 100: 1 (i.e.,' 100 ppm arginine + 1,000 ppm hyaluronic acid + 10 ppm macadamia Oil 'samples), and then the respective mixtures were applied to damaged dry hair (see &lt; test subject &gt;) and then placed in a vinyl pouch to minimize the exposure of the outside air The treatment concentration of the sample for hair treatment on the subject is shown in Table 5 below).

The following Table 5 shows the result of examining the change in the surface water content and the water content of the hair treated with the mixture of arginine, hyaluronic acid and macadamia nut oil by a TG assay (the average value was measured by measuring the water content of three samples per each sample) ).

Test subject	For hair treatment Name of sample	Processing capacity	Surface moisture  medium (65 ° C, % )	Fast water  medium (180 DEG C, % )
Normal Hair (Healthy Hair)	No treatment	-	7.950	14.190
Damaged dry hair	No treatment	-	8.260	8.510
Damaged dry hair		Solvent 1	100 [mu] L water	14.030	8.870
Damaged dry hair	Solvent 2 (Sabotam TM )	100 [mu] L alkyl benzoate	9.010	7.930
Damaged dry hair	Comparative Example 1	10ppm arginine + 10ppm hyaluronic acid + 10ppm macadamia nut oil	15.424	10.740
Damaged dry hair	Comparative Example 2	100ppm Arginine + 100ppm Hyaluronic acid + 100ppm Macadamia nut oil	12.808	11.410
Damaged dry hair	Comparative Example 3	1,000 ppm arginine + 1,000 ppm hyaluronic acid + 1,000 ppm macadamia nut oil	19.650	17.580
Damaged dry hair	Comparative Example 4	100ppm Arginine + 100ppm Hyaluronic acid + 10ppm Macadamia nut oil	13.858	14.200
Damaged dry hair	Example 1	100ppm arginine + 1,000ppm hyaluronic acid + 10ppm macadamia nut oil	15.267	18.150

As a result, as shown in Fig. 4 and Table 5, it was confirmed that a mixture of arginine, hyaluronic acid and macadamia nut oil had an effect of increasing the fast water content of hair at a proper effective content. Especially, the mixture was arginine, hyaluronic acid (Example 1) in which 100 ppm of arginine, 1000 ppm of hyaluronic acid, and 10 ppm of macadamia nut oil were mixed, compared to mixing the same at a concentration of ppm of macadamia nut oil, the synergistic effect of increasing the water content of the hair statistically significantly was found to be high ^(* against damage dry hair untreated group ^{p <0.05, ** p <0.01} , *** p <0.001)

Meanwhile, the following Table 6 shows the results of examining the changes in the surface water content and the water content of the hair treated with at least one of arginine, hyaluronic acid and macadamia nut oil by a thermogravimetric assay (three water samples per each sample were measured The average value is obtained).

Test subject	For hair treatment Name of sample	Processing capacity	Surface moisture  medium (65 ° C, % )	Fast water  medium (180 DEG C, % )
Normal Hair (Healthy Hair)	No treatment	-	7.950	14.190
Damaged dry hair	No treatment	-	8.260	8.510
Damaged dry hair		Solvent 1	100 [mu] L water	14.030	8.870
Damaged dry hair	Solvent 2 (Sabotam TM )	100 [mu] L alkyl benzoate	9.010	7.930
Damaged dry hair	Comparative Example 5	100 ppm arginine	14.330	10.080
Damaged dry hair	Comparative Example 6	1,000 ppm hyaluronic acid	15.650	11.910
Damaged dry hair	Comparative Example 7	10ppm macadamia nut oil	11.840	7.660
Damaged dry hair	Comparative Example 8	100 ppm arginine + 1,000 ppm hyaluronic acid	12.860	13.540
Damaged dry hair	Example 1	100ppm arginine + 1,000ppm hyaluronic acid + 10ppm macadamia nut oil	15.270	18.150

As a result, as shown in Fig. 5 and Table 6, the mixture of arginine, hyaluronic acid and macadamia nut oil (Example 1) was statistically significantly higher than that of the mixture of arginine and hyaluronic acid It was confirmed that the synergy effect of increasing the water content of the hair was high.

Test Example  5: Hair Surface water content  Arginine, hyaluronic acid and Macadamia  Of hair by mixture of nut oil Moisture power  Evaluation of improvement efficacy

Hyaluronic acid and macadamia nut oil in order to confirm the efficacy of increasing the hair moisture content of hair treated with at least one of arginine, hyaluronic acid and macadamia nut oil, damaged hair is treated with at least one of arginine, hyaluronic acid and macadamia nut oil, Was confirmed by a thermogravimetric assay (see Test Example 1). The concentrations of arginine, hyaluronic acid and macadamia nut oil used were the optimum concentrations determined in Test Examples 1 and 3.

Here, the test subject, the hair treatment control, the hair treatment method, and the method for measuring the hair moisturizing ability are the same as those in Test Example 1, and the mixture of arginine and hyaluronic acid is a mixture of the arginine stock solution and the hyaluronic acid stock solution 1) was prepared by diluting arginine and hyaluronic acid to a final mixing ratio (in terms of ppm) of arginine to 1:10 (that is, a sample of '100 ppm arginine + 1,000 ppm hyaluronic acid'), and arginine, hyaluronic acid and The mixture of macadamia nut oil is prepared by mixing the final mixing ratio (ppm concentration) of arginine, hyaluronic acid and macadamia nut oil with the stock solutions of arginine, hyaluronic acid and macadamia nut oil (see Test Examples 1 and 3) (I.e., "100 ppm arginine + 1,000 ppm hyaluronic acid + 10 ppm macadamia nut oil" sample) of 10: 100: 1 After each mixture was applied to damaged hair (see < test subject >), the mixture was put in a vinyl pouch to minimize the exposure of the outside air The treatment concentrations are shown in Table 6).

As a result, as shown in FIG. 6 and Table 6, it was confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil has an effect of increasing the surface moisture content of hair at a proper effective content, and in particular, arginine, hyaluronic acid and macadamia nut Oil (Example 1) was found to have a synergistic effect of increasing the surface moisture of the hair statistically significantly higher than that of the mixture of arginine and hyaluronic acid (two kinds of mixed group: Comparative Example 8).

<Statistics Processing>

The statistical analysis in Example 1 and Examples 3 to 5 was performed using a t-test as a significance test between the two groups and compared with the control group, P ^* 0.05, ^** P <0.01, ^*** P <0.001 Were regarded as valid differences.

Taken together, the results of Test Examples 1 to 5 indicate that when a mixture of arginine, hyaluronic acid and macadamia nut oil was used as a single use of arginine, hyaluronic acid and macadamia nut oil, or when arginine, hyaluronic acid and macadamia nut oil were used more than when a mixture of arginine and hyaluronic acid was used , It was confirmed that the moisture content of the hair was remarkably increased and the moisture resistance of the hair was remarkably improved.

Formulation Example 1: ointment

The ointments containing a mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention were prepared by mixing the ingredients of Table 7, including oily and aqueous components.

Compounding ingredient	content( weight% )
Purified water	Balance
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.99
Caprine / capryl triglyceride	10.00
Liquid paraffin	10.00
Sorbitan sesquioleate	6.00
Octyldodec-25	9.00
Cetyl ethyl hexanoate	10.00
Squalane	1.00
Salicylic acid	1.00
glycerin	15.00
Sorbitol	10.00

Formulation Example  2: Nourishing lotion for hair

The ingredients of Table 8, including the oily and aqueous components, were mixed to produce a hair lotion for hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention.

Compounding ingredient	content( weight% )
Purified water	Balance
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.09
Wax	4.00
Polysorbate 60	1.50
Sorbitan sesquioleate	1.50
Liquid paraffin	0.50
Montana 202 (Manufacturer: Seppic)	5.00
glycerin	3.00
Butylene glycol	3.00
Propylene glycol	3.00
Carboxyvinyl polymer	0.10
Triethanolamine	0.20
Preservative, coloring, fragrance	Suitable amount

Formulation Example  3: Massage cream for hair

The ingredients of Table 9, including the oily and aqueous components, were mixed to produce a massage cream for hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention.

Compounding ingredient	content( weight% )
Purified water	Balance
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.09
Wax	10.00
Polysorbate 60	1.50
Piggy 60 hardened castor oil	2.00
Sorbitan sesquioleate	0.80
Liquid paraffin	40.00
Squalane	5.00
Montana 202 (Manufacturer: Seppic)	4.00
glycerin	5.00
Butylene glycol	3.00
Propylene glycol	3.00
Triethanolamine	0.20
Preservative, coloring, fragrance	Suitable amount

Formulation Example  4: Hair Pack

The ingredients of Table 10 containing the oily and aqueous components were mixed to produce a hair pack comprising a mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention.

Compounding ingredient	Content (% by weight)
Purified water	Balance
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.09
Polyvinyl alcohol	13.00
Sodium carboxymethylcellulose	0.20
glycerin	5.00
Allantoin	0.10
ethanol	6.00
Phage-12 nonylphenyl ether	0.30
Polysorbate 60	0.30
Preservative, coloring, fragrance	Suitable amount

Formulation Example  5: Hair tonic

A hair tonic containing a mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention was prepared in a conventional manner according to the composition shown in Table 11.

Compounding ingredient	content( weight% )
ethanol	50.00
menthol	0.02
glycerin	3.00
Salicylic acid	0.05
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.99
Preservatives, fragrances and pigments	Suitable amount
Purified water	Balance

Formulation Example  6: Hair lotion

A hair lotion comprising a mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention was prepared in a conventional manner according to the composition shown in Table 12.

Compounding ingredient	Content (% by weight)
Cetostearyl alcohol	2.00
EDTA 2Na	0.20
Hydroxyethyl cellulose	0.50
Mineral oil	5.00
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.99
Preservatives, fragrances and pigments	Suitable amount
Purified water	Balance

Formulation Example  7: Hair conditioner  And Hair treatment

Hair rinses and hair treatments comprising a mixture of the arginine, hyaluronic acid and macadamia nut oil of the present invention were prepared in a conventional manner according to the composition shown in Table 13.

Compounding ingredient	Content (% by weight)
Propylene glycol	2.00
Cetyltrimethylammonium chloride	1.00
Cetyl alcohol	3.00
Stearyl alcohol	3.00
Mineral oil	0.50
Saitric Acid	0.20
Polydimethylsiloxane	1.00
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.99
Preservatives, fragrances and pigments	Suitable amount
Purified water	Balance

Formulation Example  8: Hair shampoo

A hair shampoo comprising a mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention was prepared by mixing the ingredients of Table 14, which comprised an oily component and an aqueous component.

Compounding ingredient	content( weight% )
Purified water	Balance
A mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention	0.99
Ammonium lauryl sulfate (ALS)	20.0
Ammonium laureth sulfate (ALES)	20.0
Coca-	Suitable amount
Disodium iodide	0.03
Carbomer	Suitable amount
ethanol	Suitable amount
Cocamide Profile Betaine	6.00
Dimethicone (50%)	2.00
Dimethicone (70%)	2.00
DL-Panthenol	Suitable amount
Tocopheryl acetate	Suitable amount
Triethanolamine	Suitable amount
menthol	Suitable amount
A mixture of methylchloroisothiazolinone methylisothiazolinone (MC / IMI)	0.03
Methylparaben	Suitable amount
Preservative, coloring, fragrance	Suitable amount

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will appreciate that such specific embodiments are merely preferred embodiments and that the scope of the present invention is not limited thereby. something to do. It is therefore intended that the scope of the invention be defined by the claims appended hereto and their equivalents.

Claims (9)

1. A cosmetic composition for improving the moisturizing power of hair containing a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient.
2. 2. The cosmetic composition according to claim 1, wherein the mixture is prepared by mixing arginine, hyaluronic acid and macadamia nut oil in a concentration of 80 to 120: 800 to 1200: 8 to 12 on a ppm basis.
3. 2. The cosmetic composition according to claim 1, wherein the content of the mixture is 0.1 to 1.0% by weight based on the total weight of the composition.
4. 2. The cosmetic composition according to claim 1, wherein the composition increases the external water content of the hair.
5. 2. The cosmetic composition according to claim 1, wherein the composition increases the internal water content of the hair.
6. The cosmetic composition according to claim 1, wherein the composition is for inhibiting moisture evaporation of damaged hair and improving moisture resistance of damaged hair.
7. 7. The cosmetic composition according to claim 6, wherein the damaged hair is caused by one or more chemical treatments selected from the group consisting of dyeing and perming, physical damage, stress or nutritional deficiency.
8. The composition according to claim 1, wherein the composition is at least one selected from the group consisting of ointments, hair lotions, hair treatments, scalp treatments, hair shampoos, and pomades, such as nourishing lotion for hair, massage cream for hair, hair pack, hair tonic, hair lotion, &Lt; / RTI &gt; wherein the composition is formulated.
9. Use of a mixture of arginine, hyaluronic acid and macadamia nut oil as an agent for improving hair moisturization in the production of cosmetic compositions or cosmetics for improving the moisture resistance of hair.

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