TWI768066B - Cosmetic composition containing mixture of arginine, hyaluronic acid and macadamia nut oil for improving moisturizing effect of hair - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a mixture of arginine, hyaluronic acid and macadamia nut oil for improving the moisturizing power of hair, and in particular to Cosmetic composition of a mixture of arginine, hyaluronic acid and macadamia oil with an internal moisture content of damaged hair). According to the cosmetic composition for improving the moisturizing power of hair, preferably damaged hair, which contains a mixture of arginine, hyaluronic acid and macadamia nut oil as active ingredients according to the present invention, by increasing the internal moisture content of hair and inhibiting hair Evaporation of internal moisture has the effect of improving the retention of moisture in the hair and increasing the retention time of the moisture in the hair.

Description

Cosmetic composition containing a mixture of arginine, hyaluronic acid and macadamia oil for improving hair moisture retention

The present invention relates to a cosmetic composition containing a mixture of arginine, hyaluronic acid and macadamia nut oil for improving the moisturizing power of hair, and in particular to Cosmetic composition of a mixture of arginine, hyaluronic acid and macadamia oil with an internal moisture content of damaged hair).

Hair is not directly related to life, but it has functions such as body protection, heat preservation, and touch, and it also acts as a buffer against external friction and protects the head from direct light, cold and heat.

In particular, the eyebrows, eyelashes, nose hair, and ear hair in the hair have the function of preventing the invasion of sweat, dust, and insects, and have the function of absorbing heavy metals such as mercury, arsenic, and lead that are unnecessary for the body and expelling them from the body.

In addition, hair plays an important role in showing masculine and feminine characteristics on the grooming side. The same person can make a different impression by changing their hairstyle and hair color. As above, the hair not only protects the head, but also functions on the grooming surface.

Hair is an elongated protein structure with an average thickness of about 0.07 mm, and is roughly divided into a hair shaft (Hair Shaft) protruding from the skin to the outside and a hair root (Hair Root) located inside the skin. The scalp has a basic structure and physiology similar to the skin, and the hair follicles of the scalp are characterized by more complex and more sebaceous glands than other parts. The root of the hair is the part inside the hair follicle, which is buried in the scalp, and has a depth of about 2 to 4 mm. The bottom part of the hair root bulges like a pearl. This part is called the Hair Bulb, and the thickness of the hair is determined according to the size of this part.

When magnifying the cross section of the hair, it is observed that there are three parts divided into the innermost part and the center of the hair medulla (Medulla), the hair cortex (Cortex) surrounding the hair medulla, and the outermost part of the hair cuticle (Cuticle). part. The epidermis covers the surface of the hair and is a chemically resistant part that surrounds the inside of the hair. From the outside, three layers called the epicuticle, the outer epidermis and the inner epidermis are formed in order. . The fur cortex is located on the inner side of the hair epidermis and occupies most of the hair (85~90%). The main component is keratin, which is composed of cortical cells and intercellular binding substances. site of action. The hair medulla is located in the center of the hair and has several melanin granules, and the medulla contains air due to many large and small vacuoles.

Hair is damaged by friction, heat, physical cutting, perming, bleaching, dyeing, sunlight, etc. First, the hair damage caused by heat is that the heat generated in the dryer after shampooing and drying evaporates the water to dry, the hair will swell and cause deformation, and the black hair will change color to dark brown. In addition, bubbles start to form in the cortex and medulla, the hair loses its elasticity, and the epidermis melts.

Second, hair damage caused by perm is caused by poor treatment of perm liquid, insufficient storage time, etc. When the hair is fragile, alkali residues in the hair, or oxidants are left, it will cause keratin denaturation and melanin fading.

Third, when an alkaline agent and hydrogen peroxide are used as decolorizing agents, the oxidative decolorization of melanin will occur due to hydrogen peroxide. If the decolorizer is used repeatedly in a short period of time, the hair will be swelled and softened repeatedly, or the cuticle will be staggered and bent, causing damage.

Finally, in the sun's rays, the keratin of the hair is damaged by infrared and ultraviolet rays, causing protein denaturation.

As described above, modern people damage their hair by perming, blowing, dyeing, etc., and it is difficult to avoid frequent shampooing due to the use of various hairdressing agents and air pollution. Many efforts have been made to restore hair damaged by frequent chemical treatments and shampooing, etc., to a healthy state, but with little success. This is because the composition of hair is different from other physiological tissues and is dead tissue, so the recovery of damaged areas is limited.

For example, in order to prevent and improve such hair damage, conditioners have been mainly used. Conditioners mainly contain long-chain quaternary ammonium compounds and higher fatty alcohols, hydrocarbon oils, and silicone oils. The above-mentioned long-chain quaternary ammonium cationic surfactants, higher fatty alcohols, and hydrocarbon oils can provide hair with luster, moisture, and softness. Silicone oil is used to reduce the dryness of the hair caused by eliminating sebum after shampooing, and artificially impart sebum-like hair. It is used to feel and make hair soft and moisturised.

Moisturizing hair is formed by the moisture inside the hair and the moisture on the surface of the hair. The softness of the hair is determined by the moisture inside the hair, and the wetness is determined by the moisture on the surface of the hair. However, since the moisture contained inside the hair is in equilibrium with the outside of the hair, it is greatly affected by the external environment, that is, temperature, humidity, ultraviolet rays, and the like. Therefore, if the initial moisture content and the moisture contained in the hair cannot be effectively preserved, the hair will be dry, disheveled, and rough.

At normal temperature and pressure (25°C, 1 atmosphere), the hair has an average moisture content of about 20%, and the moisture content varies by 3 to 34% depending on the relative humidity of the hair. Hair is structurally specific in that a lipid layer (Lipid Layer) composed of lipids is densely formed on the surface of the epidermis and a structure mainly composed of proteins called epidermis, so the moisture in the hair memory exists in the form of two physical properties. in the hair (cf. C. Barba, et . al., Thermochimica Acta , 494:136-140, 2009). This is divided into surface water (External Water) and internal water (Internal Water). Surface water is the water that evaporates when heated at 65°C for 40 minutes and mainly exists on the surface of the hair by non-covalent bonds. Moisture that evaporates when heated at 180°C for 20 minutes and is stabilized by ionic bonds with amino acids that make up the protein of hair.

In order to understand these hair moisture characteristics and effectively and fundamentally hydrate dry hair damaged by depigmentation treatments and styling, environmental (UV, haze), there is an urgent need to develop compositions that seek to control surface moisture and internal moisture separately The material can improve the elasticity, smoothness and softness of the hair through the improvement of the moisturizing ability of the inner moisture and surface moisture of the hair, and eliminate the discomfort of the user's dry hair.

Most of the conventional moisturizing mechanisms use substances that have a high affinity for water inside the hair, such as proteins or protein derivatives, to retain moisture, and then use a moisturizing agent (Moisturizer) and a conditioner (Emollier) on the outside of the hair. , and moisturizing agents (Humectant) and other anti-transpiration agents are treated to achieve moisturizing. However, although such a method maintains the moisture of the hair to a certain extent, it is impossible to completely prevent the evaporation of moisture, and the internal moisture of the hair will still form a balance with the external moisture. Therefore, it is affected by the external environment such as temperature, humidity, and ultraviolet rays, and there is a problem that it is difficult to effectively moisturize the hair.

Macadamia Nut Oil (Macadamia Ternifolia Seed Oil) is a vegetable oil extracted from macadamia nuts harvested in Australia, Hawaii, Brazil, South Africa, Israel, etc. It is colorless or bright yellow, odorless, and not easy to oxidize. More than 80% of the total weight is monounsaturated fatty acid.

Oleic acid, the main component of macadamia oil, has skin anti-aging activity, and palmitoleic acid (Palmitoleic acid), which accounts for about 20% by weight of macadamia oil, is also found in animals and constitutes animal skin. Essential component of sebum.

It has been reported that palmitoleic acid, which accounts for about 22% by weight of lipid components contained in human skin, together with palmitic acid, accounts for about half of skin sebum, and has lubrication and softening effects on the skin. , protein structure protection and other properties.

In particular, as a carrier and softener, palmitoleic acid has excellent dispersibility and permeability, excellent absorption capacity, soft and non-sticky when used on the skin, very mildly acting on the skin, preventing skin aging, making blood Or the flow of lymphatic fluid is active, protecting the skin from free radicals. Palmitoleic acid is used as a supplement for palmitoleic acid in the skin, which is reduced during skin aging. It can be used in cosmetic formulations such as creams. It helps maintain the lipid outer membrane (Lipidmantel) of the skin, making the skin smooth and easily absorbed into the skin. , so it can also be used for full body massage, suitable for all skin types, especially for dry skin or skin with reduced skin elasticity and reduced moisturizing power.

The cosmetic composition containing macadamia nut oil is not limited in terms of formulation, but may appropriately contain various components mixed in a normal cosmetic composition according to various formulations or final purposes. Taking cosmetic formulations as an example, Emollient containing about 5-10% by weight of macadamia nut oil can be used as an anti-aging supplement or sunscreen, and using about 2-10% by weight of macadamia oil for As a lipstick formulation, 100% by weight of macadamia oil can be used as baby oil or massage oil, and macadamia oil can be used as a carrier for essential oils in aromatherapy, and macadamia oil can be used as a carrier for essential oils in aromatherapy. Substitute for mineral oil or jojoba oil in creams or toners.

Under such a technical background, the present inventors have developed a cosmetic for improving hair moisturizing ability that is not affected by external environments such as temperature, humidity, or ultraviolet rays, keeps the hair moisturizing continuously, and can maintain high softness and moisturizing properties for a long period of time The composition, as a result of intensive research, found that a cosmetic composition for improving hair moisturizing power containing a mixture of arginine, hyaluronic acid and macadamia nut oil as active ingredients, by increasing the internal moisture content of the hair and inhibiting the internal moisture of the hair The effect of improving the retention capacity of the hair's internal moisture and increasing the hair's internal moisture retention time is obtained, thereby completing the present invention.

An object of the present invention is to provide a cosmetic composition containing a mixture of arginine, hyaluronic acid and macadamia nut oil as active ingredients for improving hair moisturizing power.

Another object of the present invention is to provide a cosmetic composition containing a mixture of arginine, hyaluronic acid and macadamia oil as active ingredients for improving the moisturizing power of damaged hair.

Another object of the present invention is to provide a cosmetic prepared from the above cosmetic composition.

In order to achieve the above object, the present invention provides a cosmetic composition containing a mixture of arginine, hyaluronic acid and macadamia nut oil as active ingredients for improving the moisturizing power of hair, preferably for improving the moisturizing power of damaged hair.

In addition, the present invention provides a cosmetic prepared from the above cosmetic composition.

Furthermore, the present invention provides the use of a mixture of arginine, hyaluronic acid and macadamia nut oil as a hair moisturizing improver in a cosmetic composition or cosmetic preparation for improving hair moisturizing.

Invention effect

According to the cosmetic composition for improving hair, preferably damaged hair moisturizing power (moisture retention power) according to the present invention, which contains a mixture of arginine, hyaluronic acid and macadamia nut oil as active ingredients, by increasing the internal structure of hair The moisture content and the evaporation of moisture in the hair are inhibited, and the retention force of the moisture in the hair is improved and the retention time of the moisture in the hair is increased.

Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by an expert skilled in the art to which this invention belongs. In general, the nomenclature used in this specification is well known and commonly used in the art.

"About" in terms of concentration, volume or weight in this specification means that there is a maximum allowable error of 10% in the corresponding value or value range.

In one example of the present invention, in order to confirm the effect of arginine or hyaluronic acid on increasing the moisture content in the hair, damaged dry hair was treated with arginine or hyaluronic acid, and then the moisture content in the hair was confirmed. Variety. As a result, as shown in Fig. 1 and Table 1, it can be confirmed that arginine or hyaluronic acid has the effect of increasing the moisture content in the hair at an appropriate effective content, and especially treatment with 100 ppm or more of arginine or 1000 ppm of arginine can be confirmed. The above hyaluronic acid-treated damaged dry hair statistically significantly increased the internal moisture content of the hair compared to the control group (untreated damaged dry hair) (refer to Test Example 1).

In another example of the present invention, in order to confirm the effect of free fatty acid on increasing the moisture content of the hair surface, damaged dry hair was treated with free fatty acid, and the change in the moisture content of the hair surface was confirmed. As a result, as shown in Fig. 2 and Table 2, it can be confirmed that palmitoleic acid has the effect of significantly increasing the moisture content of the hair surface at an appropriate effective content, especially, compared with the control group (damaged dry hair without treatment) Surface moisture content of hair (refer to Test Example 2).

In another embodiment of the present invention, in order to confirm the high content of macadamia nuts containing palmitoleic acid (Palmitoleic acid, cis-9-hexadecenoic, 16:1(n-7); molecular weight 254.4Da; melting point 0.5°C) in vegetable oil The effect of oil on increasing the moisture content of the hair surface. After treating damaged dry hair with macadamia nut oil, the change in the moisture content of the hair surface was checked. As a result, as shown in Fig. 3 and Table 4, it can be confirmed that macadamia nut oil has the effect of increasing the moisture content of the hair surface at an appropriate effective content. In particular, the damaged dry hair treated with 10 ppm or more of macadamia nut oil and the control group were confirmed. (untreated damaged dry hair) statistically significantly increased the amount of surface moisture in the hair. On the one hand, as shown in Table 4, even if the damaged dry hair was treated with macadamia nut oil at a final concentration of 10 ppm, 100 ppm, 1000 ppm, or 10000 ppm, there was little change in the internal moisture content of the hair (Reference Test Example 3).

Among the vegetable oils high in palmitoleic acid, not only macadamia oil (19.3% by weight), but also avocado oil (7.5% by weight), olive oil (2.5% by weight), and coconut oil (1.5% by weight) , coral oil tung oil (Jatropha, Jatropha) (1.5% by weight), almond oil (1.0% by weight), jojoba oil (1.0% by weight), etc. (refer to Jang et al., J Plant Biotechnol , 37:25-46 , 2010), avocado oil, olive oil, coconut oil, coral oil tung oil, almond oil, jojoba oil and other high-content oils containing palm oleic acid can be used as substitutes or supplements for macadamia nut oil. in the mixture.

In yet another example of the present invention, in order to confirm the effect of the mixture of arginine, hyaluronic acid and macadamia nut oil on increasing the moisture content in hair, arginine, hyaluronic acid and macadamia nut were used on damaged dry hair After the oil mixture is treated, changes in the amount of moisture in the hair are checked. As a result, as shown in Fig. 4 and Table 5, it can be confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil has the effect of increasing the moisture content in the hair at an appropriate effective content. Amino acid, hyaluronic acid, and macadamia nut oil were mixed at the same ppm concentration. When 100 ppm of arginine, 1000 ppm of hyaluronic acid, and 10 ppm of macadamia oil were mixed and used, a statistically significant increase in the amount of moisture in the hair was confirmed. The synergistic effect is high. In addition, as shown in Figure 5 and Table 6, a statistically significant increase in the mixture of arginine, hyaluronic acid and macadamia nut oil compared to the mixture of arginine and hyaluronic acid (both mixture groups) can be confirmed The synergistic effect of the moisture content in the hair was high (refer to Test Example 4).

In yet another embodiment of the present invention, in order to confirm the increasing effect of one or more of arginine, hyaluronic acid and macadamia oil on hair surface moisture, arginine, hyaluronic acid and After treatment with one or more of the macadamia oil, the change in the moisture content of the hair surface was checked. As a result, as shown in Fig. 6 and Table 6, it was confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil has the effect of increasing the moisture content of the hair surface at an appropriate effective content. In particular, arginine and hyaluronic acid Compared with the mixture of macadamia nut oil and the mixture of arginine and hyaluronic acid (two mixture groups), it was confirmed that the synergistic effect of statistically significant increase in the amount of hair surface moisture was high (refer to Test Example 5).

Accordingly, one aspect of the present invention relates to a cosmetic composition containing as active ingredients a mixture of arginine, hyaluronic acid and macadamia nut oil for improving the moisturizing power of hair, preferably damaged hair.

The above-mentioned arginine (Arginine, Arg) is transparent at normal temperature, exists in a liquid phase, is an amino acid added to perfumes, hair care agents, skin care agents, etc., and contains about 10% in the cosmetic composition according to the present invention. ~10000ppm (about 0.001~1 wt%), preferably about 100~1000 ppm (about 0.01~0.1 wt%).

The above-mentioned hyaluronic acid (Hyaluronic Acid, Hyaluronan, HA) is transparent at room temperature, exists in a liquid phase, is a substance added to a scalp protectant, a hair conditioner, etc., and the cosmetic composition according to the present invention contains about 100~100000ppm (about 0.01~10% by weight), preferably about 1000~10000ppm (about 0.1~1% by weight).

The above-mentioned Macadamia Nut Oil is transparent or yellow at room temperature, exists in a liquid phase, and is known to contain a large amount of palmitoleic acid. 0.0001~0.1% by weight), preferably about 10~100pm (about 0.001~0.01% by weight).

The mixture of arginine, hyaluronic acid and macadamia nut oil contained in the cosmetic composition of the present invention, arginine, hyaluronic acid and macadamia nut oil are based on ppm concentration, 80~120: 800~1200: 8~12 (ie, 8~12: 80~120: 0.8~1.2) for mixing, preferably 90~110: 900~1100: 9~11 (ie, 9~11: 90~110: 0.9~1.1) , the best is 10 : 100 : 1. The above-mentioned mixture mixes arginine, hyaluronic acid, and macadamia nut oil in a weight ratio (% by weight) corresponding to the mixing ratio of the above-mentioned ppm concentration.

In the present invention, considering the dosage form stability of the cosmetic composition containing the mixture of arginine, hyaluronic acid and macadamia nut oil and the use limit of cosmetic law, the content of arginine in the above mixture, arginine, hyaluronic acid The mixing ratio (ppm concentration basis) of acid and macadamia oil is kept at 80~120: 800~1200: 8~12, preferably 90~110: 900~1100: 9~11, and optimally 10:100:1 In addition, based on the total weight of the composition, it contains 0.09% by weight or less, preferably 0.01 to 0.09% by weight, more preferably 0.01 to 0.05% by weight, and arginine (arginine stock solution) is neutralized so that the pH is not Exceeds the cosmetic upper limit of pH 9.0. The content of hyaluronic acid in the above mixture, the mixing ratio (ppm concentration reference) of arginine, hyaluronic acid and macadamia nut oil is maintained at 80~120: 800~1200: 8~12, preferably 90~110: 900 In the state of ~1100:9~11, optimal 10:100:1, based on the total weight of the composition, it contains 0.9% by weight or less, preferably 0.1~0.9% by weight, more preferably 0.1~0.5% by weight. The content of macadamia nut oil in the above mixture is different according to the dosage form of the composition, and the above composition is in the form of a Wash-off hair conditioner or a leave-on (Leave-on: after being applied to the hair, it does not need to be washed with water or wiped clean, The application method of direct retention) When maintaining the hair care formulation, the content of macadamia oil, the mixing ratio (ppm concentration basis) of arginine, hyaluronic acid and macadamia oil is kept at 80~120: 800~1200: 8~12 , preferably 90~110: 900~1100: 9~11, the best 10: 100: 1 state, based on the total weight of the composition, containing 0.009% by weight or less, preferably 0.001~0.009% by weight, more Preferably 0.001 to 0.005% by weight.

In the present invention, when the content of the above-mentioned mixture is less than about 0.1% by weight (about 1000 ppm) based on the total weight of the cosmetic composition, the hair moisturizing effect is not obvious, and when it exceeds about 1.0% by weight (10000 ppm), the content increases compared to that. , the increase of its effect is not large, so the above mixture contains 0.1~1.0% by weight (1000~10000ppm), preferably 0.1~0.5% by weight (1000~5000ppm), more preferably 0.1~0.2% by weight based on the total weight of the composition % (1000~2000ppm), the best 0.111% by weight (1110ppm).

In the present invention, the above-mentioned composition can increase the external water content of hair, preferably damaged hair.

In the present invention, the above-mentioned composition can increase the internal water content of hair, preferably damaged hair.

In the present invention, the damaged hair is caused by one or more chemical treatments selected from the group consisting of dyeing and perming, physical damage, stress, or nutritional deficiencies.

The surface moisture content of the above-mentioned hair accounts for about 75% of the hair moisture content, and varies greatly depending on the relative humidity (RH), pH, temperature, etc. of the environment in which the hair is exposed.

The surface moisture of the above-mentioned hair is the moisture lost by evaporation at a temperature of about 65°C or higher, and mainly exists in the cell membrane complex (Cell Membrane Complex; CMC) of the hair epidermis.

The internal moisture content of the above-mentioned hair accounts for about 25% of the hair moisture content, and there is almost no change in the moisture content within the relative humidity (RH) range of 25 to 95% of the hair exposure environment.

The internal moisture of the hair is moisture lost by evaporation at a temperature of about 180° C. or higher, and exists in a state of hydrogen bonding with amino acids in the interlamellar space of the hair.

In the present invention, the above-mentioned composition is used for inhibiting evaporation of moisture from damaged hair and for improving moisturizing power.

In the present invention, the damaged hair is caused by one or more chemical treatments selected from the group consisting of dyeing and perming, physical damage, stress, or nutritional deficiencies, but is not limited thereto.

In the present invention, the formulation of the cosmetic composition is not particularly limited, and may include ointment, hair nourishing lotion, hair massage cream, hair mask, hair tonic, hair cream, conditioner, balm, and scalp treatment Cosmetic compositions in formulations such as shampoos, shampoos, and hair waxes. The cosmetic compositions of these respective dosage forms may appropriately contain various components mixed in ordinary cosmetic compositions according to the above-mentioned various dosage forms or final purposes, and the types and amounts of these components can be easily selected by those skilled in the art.

In the present invention, the above-mentioned cosmetic composition may be mixed with other components that are usually mixed in cosmetics. At this time, the mixed ingredients can use oil and fat ingredients, moisturizing agents, conditioners, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters , alcohol, pigments, fragrances, blood circulation enhancers, cooling agents, antiperspirants, purified water, etc.

The present invention will be described in further detail below through examples. These examples are only for illustrating the present invention, and those having ordinary knowledge in the art will naturally understand that the scope of the present invention is not limited to these examples.

Test Example 1: Evaluation of the improvement effect of arginine or hyaluronic acid on hair moisture retention by measuring the internal moisture content of hair

In order to confirm the effect of arginine or hyaluronic acid on increasing the moisture content in hair, damaged dry hair was treated with arginine or hyaluronic acid, and then the moisture content in the hair was confirmed by thermogravimetric assay. Variety.

"Test Object"

Normal hair : As standard hair, normal black hair of 10 cm length (Tress, BM-B10, Beaulax, Japan).

Damaged and dry hair : After 30 minutes of bleaching treatment on the above normal hair with a bleaching agent (1st agent: 2nd agent with a 3:1 mixture), use a shampoo (Amos Shampoo, Amore) Treated, washed with water at a temperature of 30°C for 3 minutes, and dried (in a state where the surface temperature of the hair is below 50°C, drying for 10 minutes) to obtain damaged dry hair.

"Reagents for Hair Treatment"

Reagent 1 for hair treatment : Using an arginine stock solution (obtained by dissolving arginine powder (manufacturer: Seichi) in water), the final concentrations were 10 ppm (about 0.001 wt %), 100 ppm (about 0.01 wt %), The hair of the test articles was treated at 1000 ppm (about 0.1 wt%) and 10000 ppm (about 1 wt%).

Reagent 2 for hair treatment : Using a hyaluronic acid stock solution (obtained by dissolving sodium hyaluronate (Sodium Hyaluronate Crosspolymer) (manufacturer: Nebula Bio) in water), the final concentrations were 10 ppm (0.001 wt %), 100 ppm (0.01 wt %) %), 1000 ppm (0.1 wt %) and 10000 ppm (1 wt %), the hair of the test articles was treated.

Control group : The hair of the test object was treated with water or Alkyl Benzoate (사보덤 ^TM )) in a volume of 100 μl.

"Hair Treatment"

After applying (treatment) arginine (agent 1 for hair treatment) or hyaluronic acid (agent 2 for hair treatment) at a concentration of 10ppm, 100ppm, 1000ppm or 10000ppm on damaged and dry hair (refer to "Test Items"), Packed in plastic bags to minimize exposure to outside air (see Table 1 below for treatment concentrations of hair treatment agents for test articles).

"Hair moisturizing power measurement method: Thermogravimetric assay (Thermogravimetric assay)"

The moisture content of hair (untreated normal hair; untreated damaged dry hair; damaged dry hair treated with arginine or hyaluronic acid) was measured using a moisture meter (MS-70, A&D, Japan) (measurement Three samples of each reagent (triplicate samples) moisture content, average). At this time, the moisture content of the hair was measured by heating in two stages at 65°C (program 5) and 180°C (program 3) until the hair moisture content measured by the sensor of the moisture meter was 0.02% (w/ w), measure the cumulative water evaporation [%(w/w)] in 3~30 minutes (refer to C. Barba, et . al., Thermochimica Acta , 494:136-140, 2009; Yash Kamath, et . al., J. Cosmet. Sci. , 65:37-48, 2014; Clarence R. Robbins, Chemical and Physical Behavior of Human Hair , Chapter, 2.10 "Water: A Fundamental Component of Human Hair", 5th Edition, 2010).

Table 1 below shows the results of the changes in the surface moisture content and the internal moisture content of the hair treated with arginine or hyaluronic acid by thermogravimetric assay (Thermogravimetric assay). Table 1

As a result, as shown in Fig. 1 and Table 1, it can be confirmed that arginine or hyaluronic acid has the effect of increasing the moisture content in the hair at an appropriate effective content, and especially treatment with 100 ppm or more of arginine or 1000 ppm of arginine can be confirmed. The above hyaluronic acid treated damaged dry hair statistically significantly increased the amount of internal moisture in the hair compared to the control (untreated damaged dry hair).

Test Example 2: Evaluation of the improvement effect of free fatty acid on hair moisture retention by measuring the surface moisture content of hair

In order to confirm the effect of free fatty acid on increasing the moisture content of the hair surface, damaged dry hair was treated with different types of free fatty acids, and then the change in the moisture content of the hair surface was confirmed by thermogravimetric assay (Thermogravimetric assay; see Test Example 1). [Control: Alkyl Benzoate (사보덤 ^c )].

Table 2 below shows the results of checking the changes in the surface moisture content and the internal moisture content of hair treated with free fatty acid by thermogravimetric assay (the moisture content of three samples of each reagent was measured, and the average value was obtained). Table 2

As a result, as shown in Fig. 2 and Table 2, it can be confirmed that palmitoleic acid has the effect of significantly increasing the moisture content of the hair surface at an appropriate effective content, especially compared with the control group (damaged dry hair without treatment), increasing the amount of hair. surface moisture content.

Test Example 3: Evaluation of the improvement effect of macadamia nut oil on hair moisturizing power by measuring the surface moisture content of hair

In order to confirm the increasing effect of macadamia nut oil containing palmitoleic acid in the hair surface moisture content, damaged dry hair was treated with macadamia nut oil, and then a thermogravimetric assay (Thermogravimetric assay; see Test Example 1) was used. ) to confirm the change in the moisture content of the hair surface [control group: Alkyl Benzoate (사보덤 ^TM )].

"Reagents for Hair Treatment"

Reagent 3 for hair treatment: Macadamia Nut Oil stock solution (Macadamia Integrifolia Seed Oil or Macadamia Ternifolia Seed Oil) was used as Macadamia Nut Oil (preparator: ADM, B&H Tech) was dissolved in Alkyl Benzoate (manufactured by 사보덤 ^™ ) to make final concentrations of 10 ppm (0.001 wt %), 100 ppm (0.01 wt %), 1000 ppm (0.1 wt %) and 10000 ppm (1 wt %), the hair of the test articles was treated.

Here, the test article, the control group for hair treatment, the hair treatment method, and the hair moisturizing force measurement method are the same as those in Test Example 1.

The above-mentioned agent 3 for hair treatment or the vegetable oil contained in the mixture of arginine, hyaluronic acid and vegetable oil described later utilizes the macadamia nut oil containing palm oleic acid high in free fatty acid.

The composition of the free fatty acid contained in the macadamia nut oil stock solution (manufacturer: B&H Tech) used in the present invention is shown in Table 3 below. The content of palmitoleic acid in the above-mentioned stock solution is 15.0 to 22.0% by weight. table 3

Table 4 below shows the results of checking the changes in the surface moisture content and the internal moisture content of the hair treated with macadamia nut oil by thermogravimetric assay (the moisture content of three samples of each reagent was measured, and the average value was obtained). Table 4

As a result, as shown in Fig. 3 and Table 4, it can be confirmed that macadamia nut oil has the effect of increasing the moisture content of the hair surface at an appropriate effective content. In particular, the damaged dry hair treated with 10 ppm or more of macadamia nut oil and the control group were confirmed. (untreated damaged dry hair) statistically significantly increased the amount of surface moisture in the hair.

On the one hand, as shown in Table 4, even if the damaged dry hair was treated with macadamia oil at a final concentration of 10 ppm, 100 ppm, 1000 ppm, or 10000 ppm, there was little change in the internal moisture content of the hair.

Test Example 4: Evaluation of the improvement effect of the mixture of arginine, hyaluronic acid and macadamia nut oil on hair moisture retention by measuring the internal moisture content of the hair

In order to confirm the effect of increasing the moisture content of hair treated with one or more of arginine, hyaluronic acid and macadamia oil, one or more of arginine, hyaluronic acid and macadamia oil was used on damaged dry hair After the treatment, the change in the moisture content in the hair was confirmed by thermogravimetric assay (Thermogravimetric assay; see Test Example 1). The concentrations of the above-mentioned arginine, hyaluronic acid and macadamia nut oil were used as the most appropriate concentrations confirmed in Test Example 1 and Test Example 3.

Here, the test object, the control group for hair treatment, the hair treatment method and the hair moisturizing force measurement method are the same as those in Test Example 1, and the mixture of arginine, hyaluronic acid and macadamia nut oil is used in the preparation of the hair treatment agent The arginine stock solution, hyaluronic acid stock solution and macadamia oil stock solution (refer to Test Example 1 and Test Example 3) were prepared by diluting with water to make the final mixing ratio of arginine, hyaluronic acid and macadamia oil (ppm concentration reference). ) 1:1:1 (ie, "10ppm arginine + 10ppm hyaluronic acid + 10ppm macadamia oil" reagent; "100ppm arginine + 100ppm hyaluronic acid + 100ppm macadamia oil" reagent; "1000ppm arginine" +1000ppm hyaluronic acid + 1000ppm macadamia oil" reagent), 10:10:1 (ie, "100ppm arginine + 100ppm hyaluronic acid + 10ppm macadamia oil" reagent) and 10:100:1 (ie, "" 100ppm arginine + 1000ppm hyaluronic acid + 10ppm macadamia nut oil" reagent), then apply (treat) each of the above mixtures to damaged and dry hair (refer to "Test Objects"), put it in a plastic bag, and let the external Exposure to air was minimized (see Table 5 below for treatment concentrations of hair treatment agents for test articles).

Table 5 below shows the results confirmed by thermogravimetric assay (Thermogravimetric assay) of changes in the surface moisture content and internal moisture content of hair treated with a mixture of arginine, hyaluronic acid and macadamia oil (three samples of each reagent were measured moisture content, average). table 5

As a result, as shown in Fig. 4 and Table 5, it can be confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil has the effect of increasing the moisture content in the hair at an appropriate effective content. Amino acid, hyaluronic acid, and macadamia nut oil were mixed at the same ppm concentration, and when 100 ppm of arginine, 1000 ppm of hyaluronic acid, and 10 ppm of macadamia nut oil were mixed and used (Example 1), a statistically significant increase was confirmed. The synergistic effect of moisture content in the hair was high (damaged dry hair vs. no treatment *p<0.05, **p<0.01, ***p<0.001).

In addition, the following Table 6 shows the results of the thermogravimetric assay (Thermogravimetric assay) of the changes in the surface moisture content and the internal moisture content of the hair treated with one or more of arginine, hyaluronic acid, and macadamia nut oil (measurement of each reagent). The moisture content of the three samples was averaged). Table 6

The results are shown in Fig. 5 and Table 6. The mixture of arginine, hyaluronic acid and macadamia nut oil (Example 1) was comparable to the mixture of arginine and hyaluronic acid (two mixture groups: Comparative Example 8). It was confirmed that the synergistic effect of statistically significantly increasing the amount of moisture in the hair was high.

Test Example 5: Evaluation of the improvement effect of the mixture of arginine, hyaluronic acid and macadamia nut oil on hair moisture retention by measuring the surface moisture content of the hair

In order to confirm the effect of increasing the surface moisture content of hair treated with one or more of arginine, hyaluronic acid, and macadamia oil, one or more of arginine, hyaluronic acid, and macadamia oil was applied to damaged dry hair. After the treatment, the change in the moisture content of the hair surface was confirmed by thermogravimetric assay (Thermogravimetric assay; see Test Example 1). The concentrations of the above-mentioned arginine, hyaluronic acid and macadamia nut oil were used as the most appropriate concentrations confirmed in Test Example 1 and Test Example 3.

Here, the test article, the control group for hair treatment, the hair treatment method and the hair moisturizing power measurement method are the same as those in Test Example 1, and the mixture of arginine and hyaluronic acid is the arginine used in the preparation of the hair treatment agent The stock solution and the hyaluronic acid stock solution (refer to Test Example 1) were prepared by diluting with water so that the final mixing ratio (ppm concentration standard) of arginine and hyaluronic acid was 1:10 (ie, "100 ppm arginine + 1000 ppm hyaluronic acid"). "Reagent); the mixture of arginine, hyaluronic acid and macadamia nut oil is the arginine stock solution, hyaluronic acid stock solution and macadamia nut oil stock solution used in the preparation of hair treatment reagents (refer to Test Example 1 and Test Example 3) Prepare by diluting with water so that the final mixing ratio (ppm concentration basis) of arginine, hyaluronic acid and macadamia nut oil is 10:100:1 (ie, "100ppm arginine + 1000ppm hyaluronic acid + 10ppm macadamia nut oil") Oil” agent), then apply (treat) each of the above mixtures to damaged, dry hair (refer to “Test Articles”), then place in a plastic bag to minimize exposure to outside air (hair treatment of test articles). Refer to Table 6 for the treatment concentrations of the reagents.

As a result, as shown in Fig. 6 and Table 6, it was confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil has the effect of increasing the moisture content of the hair surface at an appropriate effective content. In particular, arginine and hyaluronic acid Compared with the mixture of macadamia nut oil (Example 1) and the mixture of arginine and hyaluronic acid (two mixture groups: Comparative Example 8), it can be confirmed that the synergistic effect of statistically significantly increasing the amount of hair surface moisture is high. .

"Statistical Processing"

The statistical analysis in Example 1 and Examples 3 to 5 is the investigation of significant differences between the two groups, using the t-test identification method, compared with the control group, *P<0.05, **P<0.01, *** When P<0.001, it was considered as a significant difference.

Comprehensively considering the results of Test Examples 1 to 5, it was confirmed that the use of arginine, hyaluronic acid and macadamia nut oil was compared with the use of arginine, hyaluronic acid and macadamia oil alone, or the use of a mixture of arginine and hyaluronic acid. When mixed with argan oil, it can significantly increase the internal moisture content of the hair and significantly improve the moisturizing power of the hair.

Formulation Example 1: Ointment

The ingredients of Table 7 including oil phase ingredients and water phase ingredients were mixed to prepare an ointment containing the mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention. Table 7

Formulation Example 2: Nutritional Lotion for Hair

The ingredients of Table 8 including the oil phase ingredient and the water phase ingredient were mixed to prepare a hair nourishing lotion containing the mixture of arginine, hyaluronic acid and macadamia oil of the present invention. Table 8

Formulation Example 3: Massage Cream for Hair

The ingredients of Table 9 including oil phase ingredients and water phase ingredients were mixed to prepare a hair massage cream containing the mixture of arginine, hyaluronic acid and macadamia oil of the present invention. Table 9

Formulation Example 4: Hair Mask

The ingredients of Table 10, including the oil phase ingredients and the water phase ingredients, were mixed to prepare a hair mask containing the mixture of arginine, hyaluronic acid and macadamia oil of the present invention. Table 10

Formulation Example 5: Hair Restorative Oil

According to the composition described in Table 11, a hair tonic oil containing the mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention was prepared by a usual method. Table 11

Formulation Example 6: Hair Cream

According to the composition described in Table 12, a hair cream containing the mixture of arginine, hyaluronic acid and macadamia nut oil of the present invention was prepared by an ordinary method. Table 12

Formulation Example 7: Conditioner and Ointment

According to the composition described in Table 13, a conditioner and a baking ointment containing the mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention were prepared by an ordinary method. Table 13

Formulation Example 8: Shampoo

The ingredients of Table 14 including the oil phase ingredient and the water phase ingredient were mixed to prepare a shampoo containing the mixture of arginine, hyaluronic acid and macadamia oil of the present invention. Table 14

The specific parts of the content of the present invention are described in detail above, and those with ordinary knowledge in the art should understand that these specific techniques are only preferred embodiments, and the scope of the present invention is not limited thereto. Accordingly, the essential scope of the present invention is to be defined in accordance with the appended claims and their equivalents.

Figure 1 shows the change in hair moisture content of damaged dry hair treated with arginine or hyaluronic acid (plot: mean (Mean) ± standard error of measurement (SEM)). Figure 2 shows the change in hair surface moisture content of damaged dry hair treated with free fatty acid (pattern: mean (Mean) ± standard error of measurement (SEM)). Figure 3 shows the change in the hair surface moisture content of damaged dry hair treated with macadamia oil (map: mean ± standard error of measurement (SEM)). Figure 4 shows the change in hair moisture content of damaged dry hair treated with a mixture of arginine, hyaluronic acid and macadamia oil (Map: Mean ± Standard Error of Measurement (SEM)). Figure 5 shows the change in hair moisture content of damaged dry hair treated with more than one of arginine, hyaluronic acid and macadamia oil (map: mean ± standard error of determination (SEM)). Figure 6 shows the change in hair surface moisture content of damaged dry hair treated with more than one of arginine, hyaluronic acid and macadamia oil (Map: Mean ± Standard Error of Measurement (SEM)).

Claims (9)

A cosmetic composition for improving the moisturizing power of damaged hair for increasing the internal moisture content of damaged hair, the cosmetic composition for improving the moisturizing power of hair containing arginine, hyaluronic acid and macadamia nut oil as active ingredients mixture. The cosmetic composition for improving the moisturizing power of damaged hair for increasing the internal moisture content of damaged hair as described in claim 1, wherein the mixture is arginine, hyaluronic acid and macadamia nut oil with 80~120:800~1200:8~12 mixed based on ppm concentration. The cosmetic composition for improving the moisturizing power of damaged hair for increasing the internal moisture content of damaged hair as described in claim 1, wherein the content of the mixture is 0.1 to 1.0 with respect to the total weight of the composition weight%. The cosmetic composition for improving the moisturizing power of damaged hair for increasing the moisture content of damaged hair according to claim 1, wherein the macadamia nut oil contains lauric acid, myristic acid (Myristic Acid), Palmitic Acid, Palmitoleic Acid, Stearic Acid, Oleic Acid, Linoleic Acid, Linolenic Acid, Free fatty acids composed of Arachidic Acid, Eicosenoic Acid and Behenic Acid. The cosmetic composition for improving the moisturizing power of damaged hair for increasing the moisture content of damaged hair as described in claim 4, wherein the macadamia nut oil contains, with respect to the total weight of the macadamia nut oil Less than 0.5% by weight of lauric acid, 0.5 to 1.6% by weight of myristic acid, 7.0 to 9.5% by weight of palmitic acid, 15.0 to 22.0% by weight Amount% of palmitoleic acid, 2.0 to 5.5% by weight of stearic acid, 55.0 to 67.0% by weight of oleic acid, 1.0 to 5.0% by weight of linoleic acid, 0.1 to 3% by weight of linolenic acid, 1.5 to 3.0% by weight The free fatty acid composed of arachidic acid, 1.5-3.0 wt% eicosenoic acid and 0.1-1.0 wt% behenic acid. The cosmetic composition for improving the moisturizing power of damaged hair for increasing the moisture content of damaged hair as described in claim 1, wherein the mixture has the properties of inhibiting evaporation of moisture in damaged hair and improving the moisture retention of damaged hair. Internal moisture retention activity. The cosmetic composition for improving the moisturizing power of damaged hair for increasing the moisture content of damaged hair according to claim 1, wherein the damaged hair is at least one selected from the group consisting of dyeing and perming caused by chemical treatment, physical injury, stress, or nutritional deficiencies. The cosmetic composition for improving the moisturizing power of damaged hair for increasing the internal moisture content of damaged hair as described in claim 1, wherein the composition is formulated into a formulation selected from the group consisting of ointment, nutritional lotion for hair, One of the group consisting of massage cream for hair, hair mask, hair oil, hair cream, conditioner, balm, scalp treatment, shampoo and hair wax. Use of a mixture of arginine, hyaluronic acid and macadamia nut oil in the preparation of a cosmetic composition or cosmetic for improving the moisturizing power of damaged hair for increasing the internal moisture content of damaged hair.

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