CN105748341A

CN105748341A - Cosmetic moisturizing composition and use method

Info

Publication number: CN105748341A
Application number: CN201510953964.2A
Authority: CN
Inventors: 琳达·哈特
Original assignee: Mary Kay Co Ltd
Current assignee: Mary Kay Co Ltd; Kay Mary Inc
Priority date: 2014-12-19
Filing date: 2015-12-18
Publication date: 2016-07-13

Abstract

The invention relates to a method of moisturizing skins and hairs and a composition, which comprises petrolatum, mineral oil, paraffin, hydrogenated soy glyceride, stearic acid, and opuntia tuna fruit extract.

Description

Cosmetics moisture-keeping composition and using method

The cross reference of related application

This application claims the rights and interests of the U.S. Provisional Application the 62/094793rd of December in 2014 submission on the 19th.The content of referenced application is incorporated by reference in the application.

Technical field

This invention relates generally to be configured to make skin and the field of the moistening cosmetic composition of hair.

Background technology

Wetting agent is the compound mixture being specifically designed to the more soft and more pliable and tougher chemical agent of outer layer (epidermis) so that skin.They increase the hydration (water content) of skin by reducing evaporation.Naturally occurring skin lipid and sterol and artificial or natural oil, wetting agent, emollient, lubricant etc. can be parts for the composition of commercially available skin moisturizer.They can be used as the commercially available prod of cosmetic and therapeutic use and obtain but it also may use conventional medicine composition to prepare at home.Some problems relevant to wetting agent include product and produce greasy or oily sensation and the stability of difference.

Summary of the invention

The inventors have discovered that the defect that the present invention overcomes in this area by providing stable skin and hair moisture-keeping composition, described moisture-keeping composition can also effectively be protected skin and hair and play the effect for normal skin and hair and the dry position such as emollient of hand, ancon and foot.It addition, embodiment of the present invention can make skin and hair moisten and play the effect of emollient when user is slept.

In one aspect, humectant composition is disclosed.In an example, humectant composition include vaseline, mineral oil, paraffin, hydrogenated soy glyceride, stearic acid and prickly-pear cactus (Opuntiatuna) fruit extract any one, its combination in any or they are whole.In compositions, the amount of composition can change (such as, amount can be low to moderate 0.000001 weight % to high to 80 weight % (w/w), or any range therebetween).In an example, compositions comprises: the prickly-pear cactus fruit extract of the vaseline of 25 weight % to 75 weight %, the mineral oil of 10 weight % to 50 weight %, the paraffin of 1 weight % to 15 weight %, the hydrogenated soybean grease of 0.5 weight % to 5 weight %, the stearic acid of 0.1 weight % to 1 weight % and 0.0001 weight % to 0.01 weight %.Compositions can also comprise one or more of composition described herein.Such as, compositions can comprise one or more of supplementary element, and it is selected from one or more of regulators, wetting agent, pH adjusting agent, structural agent, inorganic salt and preservative.

On the other hand, any one of moisture-keeping composition described herein is also included as a kind of wax or the supplementary element of multiple wax.A kind of wax or multiple wax can be Cera Flava, little candle tree (Euphorbiacerifera) (may lira) wax and babassu (Coperniciacerifera) (Petiolus Trachycarpi) wax any one, its combination in any or they are whole.In compositions, the amount of composition can change (such as, amount can be low to moderate 0.000001 weight % to high to 80 weight %, or any range therebetween).In an example, compositions comprises: babassu (Petiolus Trachycarpi) wax of the Cera Flava of 1 weight % to 10 weight %, little candle tree (may the ground lira) wax of 1 weight % to 10 weight % and 0.1 weight % to 10 weight %.

In another further aspect, any one of moisture-keeping composition described herein is also included as a kind of oil or the supplementary element of multiple oil.A kind of oily or multiple oil can be any one in Semen Ricini (Ricinuscommunis) seed oil, Helianthi (Helianthusannuus) (sunflower) seed oil and wild soybean (Glycinesoja) (Semen sojae atricolor) oil, its arbitrary composition or they are whole.In compositions, the amount of composition can change (such as, amount can be low to moderate 0.000001 weight % to high to 80 weight %, or any range therebetween).In an example, compositions comprises: Semen Ricini (Semen Ricini) seed of 0.01 weight % to 1 weight % is oily, Helianthi (sunflower) seed of 0.01 weight % to 1 weight % oil is oily with the wild soybean (Semen sojae atricolor) of 0.00001 weight % to 1 weight %.

It yet still another aspect, any one of moisture-keeping composition described herein also comprise spice and/or dyestuff any one, its combination in any or they are whole.In compositions, the amount of composition can change (such as, amount can be low to moderate 0.000001 weight % to high to 80 weight %, or any range therebetween).In an example, compositions comprises spice.In another example, compositions comprises the spice of 0.1 weight % to 3 weight %.In another example, compositions comprises dyestuff.Compositions can comprise the dyestuff of 0.01 weight % to 1 weight %.Compositions can also comprise spice and dyestuff.In an example, compositions can comprise the spice of 0.1 weight % to 3 weight % and the dyestuff of 0.01 weight % to 1 weight %.

Additionally, in other respects, any one in moisture-keeping composition described herein is anhydrous.

Also disclose the using method of compositions described herein.In one aspect, disclosed compositions is for by making skin or hair moisten disclosed compositions application to skin or hair.

In yet another aspect, to skin or hair and make compositions stay on skin or hair by using compositions disclosed herein, disclose disclosed compositions for making skin or the moistening using method of hair.

In other respects, to skin or hair and make compositions stay on skin or hair more than 1 hour by using disclosed compositions, disclose disclosed compositions for making skin or the moistening using method of hair.

In another, to the skin of object or hair and make compositions stay on skin or hair when object is slept by using disclosed compositions, disclose disclosed compositions for making the skin of object or the using method that hair is moistening.

In some respects, the compositions of the present invention is formulated as topical skin composition.Compositions can have the acceptable supporting agent of the dermatological for compound, compositions and extract or carrier.Compositions can comprise wetting agent or wetting agent, surfactant, compound containing silicone, UV agent, oil and or this specification other compositions determined or composition as known in the art further.Compositions can be lotion, cream, gel, elite, emulsion (such as oil-in-water, Water-In-Oil, water bag silicone, silicone Bao Shui, W/O/W, Water-In-Oil bag oil, silicone bag oil-in-water etc.), solution (such as aqueous solution or water-alcohol solution), anhydrous substrate (such as lipstick or powder), ointment, emulsion, patch, aerosol, solid form, eye curry etc..Compositions can be powder type (such as dry, lyophilizing, microgranule etc.).Compositions can prepare for local skin every day during use use at least 1,2,3,4,5,6,7 or more times.In the other side of the present invention, said composition can be stable storing or colour stable, or both.nullIt is also contemplated that the viscosity of compositions can be selected to reach desired result，Such as according to desired types of compositions，The viscosity of said composition can for 1cps to exceeding well over 1,000,000 cps，Or wherein available any range or integer be (such as，With TC axle with the 2.5rpm 2cps measured on Brookfield viscometer at 25 DEG C、3、4、5、6、7、8、9、10、20、30、40、50、60、70、80、90、100、200、300、400、500、600、700、800、900、1000、2000、3000、4000、5000、6000、7000、8000、9000、10000、20000、30000、40000、50000、60000、70000、80000、90000、100000、200000、300000、400000、500000、600000、700000、800000、900000、1000000、2000000、3000000、4000000、5000000、10000000cps etc.).

The compositions of the present invention can also modifiy have desired oxygen-derived free radicals absorbability (ORAC) value.nullIn some is non-limiting，The compositions of the determined present invention or its composition or extract can change to have every milligram at least about 1 in this specification、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、35、40、45、50、55、60、70、80、90、95、100、200、300、400、500、600、700、800、900、1000、2000、3000、4000、5000、6000、7000、8000、9000、10000、15000、20000、30000、50000、100000 or more，Or the wherein ORAC value of available any range.

Said composition can have the pH value of about 6 to about 9 in non-limiting.In other side, pH can be 1,2,3,4,5,6,7,8,9,10,11,12,13 or 14.Compositions can comprise triglyceride.Limiting examples includes the triglyceride of chainlet, Medium chain and big chain.In some respects, triglyceride is median chain triglyceride oil (such as three Miglyol 812).Compositions can also comprise preservative.The limiting examples of preservative includes the mixture of methyl parahydroxybenzoate, propyl p-hydroxybenzoate or methyl parahydroxybenzoate and propyl p-hydroxybenzoate.In some embodiments, compositions does not comprise p-Hydroxybenzoate.

The compositions of the present invention can have UVA and UVB absorbent properties.Said composition can have a SPF (sun protection factor) (SPF) of 2,3,4,5,6,7,8,9,10,11,12,13,14,15,20,25,30,35,40,45,50,55,60 or bigger, or wherein available arbitrary integer.Said composition can be sunlight lotion, spraying or cream.

The compositions of the present invention can also comprise in following supplementary element any one, combination in any or all: water, chelating agen, wetting agent, preservative, thickening agent, compound containing silicone, quintessence oil, structural agent, vitamin, ingredient or antioxidant, or the mixture of the combination in any of this constituents or this constituents.In some aspects, in these supplementary elements that said composition is pointed in sentence before may be embodied at least two, three, four, five, six, seven, eight, nine, ten kind or all.The limiting examples of these supplementary elements is pointed out in the whole text in this specification and is incorporated by reference into this part.The amount of this constituents can be 0.0001% to 99.9% of the weight or volume in compositions, or in arbitrary integer disclosed in this specification other parts or scope, it is incorporated by reference into this section.

Further relate to the cosmetics suit of the compositions comprising the present invention.In certain embodiments, said composition comprises in a reservoir.This container can be bottle, allotter or packaging.This container can distribute the compositions of scheduled volume.In some respects, compositions is distributed with spraying, mist, agglomerate or fluid.Container can comprise labelling in its surface.This labelling can be word, abbreviation, picture or symbol.

What further relate to is that the disclosed in the whole text described compositions of this specification is used as leave or rinse-off compositions.For example, leave compositions can retain a period of time (such as by application to skin partly and on skin, at least 5,6,7,8,9,10,20 or 30 minutes, or at least 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23 or 24 hours, or whole night or whole daytime) compositions.Or, rinse-off compositions can be intended to application to skin, then a period of time as less than 5, in 4,3,2 or 1 minutes from skin removed or the product washing away (such as with water).The example of rinse-off compositions can be skin cleaner, shampoo, hair conditioner or soap.Example of leave compositions can be skin moisturizer, sunscreen, facial film, late frost or day cream.

Being contemplated that in this specification discussed any embodiment can implement for any means of the present invention or compositions, and vice versa.Additionally, the compositions of the present invention may be used for realizing the method for the present invention.

In one embodiment, the compositions of the present invention can be pharmaceutically useful or can be cosmetic, maybe can have comfortable tactile properties." pharmaceutically useful ", " can be cosmetic " and/or " comfortable tactile properties " describe there is the specific tactile properties making dermal sensation comfortable compositions (such as, be not too water or too oily compositions, there is the compositions etc. of the sliding compositions of quality of silk, non-stickiness or stickiness.).Pharmaceutically useful or cosmetic can also relate to creaminess or the greasy property of compositions or the moisture retention property of compositions.

Also contemplate the product of a kind of compositions comprising the present invention.In non-limiting, this product can be cosmetics.These cosmetics can be those described in other chapters and sections of this specification, or well known by persons skilled in the art those.The limiting examples of product includes moisturiser, cream, honeydew, toner/smoothing toner, gel, astringent, foundation cream, late frost, lipstick, cleaning agent, cosmetic water, sunscreen cream, facial film, aging products, deodorizer, antiperspirant, perfume, cologne etc..

Present disclosure also discloses embodiment scheme 1 to 20.Embodiment 1 is the humectant composition comprising following component: vaseline, mineral oil, paraffin, hydrogenated soy glyceride, stearic acid and prickly-pear cactus fruit extract.Embodiment 2 is the cosmetic composition described in embodiment 1, and wherein said compositions comprises: the prickly-pear cactus fruit extract of the vaseline of 25 weight % to 75 weight %, the mineral oil of 10 weight % to 50 weight %, the paraffin of 1 weight % to 15 weight %, the hydrogenated soybean grease of 0.5 weight % to 5 weight %, the stearic acid of 0.1 weight % to 1 weight % and 0.0001 weight % to 0.01 weight %.Embodiment 3 is the cosmetic composition according to any one of embodiment 1 and 2, and it is also included as the supplementary element of mixture of wax or wax.Embodiment 4 is the cosmetic composition described in embodiment 3, and wherein the supplementary element for wax is selected from: Cera Flava, little candle tree (bearing ground lira) wax and babassu (Petiolus Trachycarpi) wax.Embodiment 5 is the cosmetic composition described in embodiment 3, is wherein the supplementary element of mixture of the wax at least two in following: Cera Flava, little candle tree (may lira) wax and babassu (Petiolus Trachycarpi) wax.Embodiment 6 is the cosmetic composition described in embodiment 5, and wherein said compositions comprises: Brazil wax (Petiolus Trachycarpi) wax of the Cera Flava of 1 weight % to 10 weight %, little candle tree (may the ground lira) wax of 1 weight % to 10 weight % and 0.1 weight % to 10 weight %.Embodiment 7 is the cosmetic composition according to any one of embodiment 1 to 6, and it is also included as the supplementary element of mixture of oil or oil.Embodiment 8 is the cosmetic composition described in embodiment 7, and wherein the supplementary element for oil is selected from: Semen Ricini (Semen Ricini) seed oil, Helianthi (sunflower) seed oil and wild soybean (Semen sojae atricolor) oil.Embodiment 9 is the cosmetic composition described in embodiment 7, and wherein the supplementary element for the mixture of oil comprises following at least two: Semen Ricini (Semen Ricini) seed oil, Helianthi (sunflower) seed oil and wild soybean (Semen sojae atricolor) oil.Embodiment 10 is the cosmetic composition described in embodiment 9, and wherein said compositions comprises: Semen Ricini (Semen Ricini) seed of 0.01 weight % to 1 weight % is oily, Helianthi (sunflower) seed of 0.01 weight % to 1 weight % oil is oily with the wild soybean (Semen sojae atricolor) of 0.00001 weight % to 1 weight %.Embodiment 11 is the compositions according to any one of embodiment 1 to 10, and it also comprises spice.Embodiment 12 is the compositions described in embodiment 11, and wherein said compositions comprises the spice of 0.1 weight % to 3 weight %.Embodiment 13 is the compositions according to any one of embodiment 1 to 12, and it also comprises dyestuff.Embodiment 14 is the compositions described in embodiment 13, and wherein said compositions comprises the dyestuff of 0.01 weight % to 1 weight %.Embodiment 15 is the compositions according to any one of embodiment 1 to 14, and wherein said compositions is anhydrous.Embodiment 16 is the compositions according to any one of embodiment 1 to 15, and wherein said compositions is configured to make skin and hair moisten.Embodiment 17 is a kind of method making skin and hair moisten, wherein by the compositions application to skin according to any one of embodiment 1 to 16 or hair.Embodiment 18 is the method making skin and hair moisten of embodiment 17, and it also includes making compositions stay on skin or hair.Embodiment 19 is the method making skin and hair moisten of embodiment 18, and it also includes making compositions stay on skin or hair more than 1 hour.Embodiment 20 is to make the skin of object and the moistening method of hair, and it includes using compositions according to any one of embodiment 1 to 16 to the skin of object or hair and makes compositions stay on skin or hair when object is slept.

" local application " refers to and uses or coating composition is to the surface of lip or collenchyme." topical skin composition " includes the compositions being adapted at lip or collenchyme local application.It is acceptable that this based composition is generally dermatological, this is because when being administered to lip or skin, it does not have undue toxicity, incompatibility, unstability, anaphylaxis etc..The topical skin care compositions of the present invention can have selected viscosity to avoid being administered to significantly drippage or alluvial after skin.

" collenchyme " includes configuring the layer containing cutin as mammals outermost protective layer, and including but not limited to lip, skin, hair and fingernail.

Term " about " or " about " be defined as one of ordinary skill in the understanding close to, and this term is defined as within 10% in one non-limiting embodiment, it is preferable that within 5%, within 1%, it is most preferred that within 0.5%.

Term " substantially " and variant thereof be defined as one of ordinary skill in the understanding major part but differ be decided to be specified whole, and essentially refer in one non-limiting embodiment within 10%, scope within 5%, within 1% or within 0.5%.

Any measurable minimizing that any variant of term " suppression " or " minimizing " or these terms includes realizing expected result or suppress completely.Protein that any variant of term " promotion " or " increase " or these terms includes realizing expected result or molecule are (such as, stromatin is fibronectin, laminin，LN, collagen protein or elastin laminin such as, or molecule such as hyaluronic acid) any measurable increase or generation.

When using in this specification and/or claim, term " effectively " represents enough to realize result that is desired, intended or that want.

When using together with term " comprising " in claim and/or description, before key element, usage quantity word can not represent " one ", but it also complies with the meaning of " one or more ", " at least one " and " one or more than one ".

As specification and claims use, word " comprises ", " having ", " including " or " containing " are inclusives or open, and are not excluded for element other, that do not enumerate or method step.

Compoistion and method of use can " comprise " this specification composition disclosed in the whole text or step any one, " being mainly made up of it " or " being made up of it ".

The other objects, features and advantages of the present invention can be become apparent upon by detailed description below.It should be understood, however, that detailed description and embodiment only provide in the illustrated manner when showing specific embodiments of the present invention.Additionally, it is contemplated that by this detailed description, changing and modifications in the spirit and scope of the present invention can become apparent upon for those skilled in the art.

Detailed description of the invention

As described above, some aspects of the unique aspect of the present invention provide stable skin and hair moisture-keeping composition, and described moisture-keeping composition can also effectively be protected skin and hair and play the effect for normal skin and the emollient at hair and dry position.It addition, another unique aspect of the present invention provides the moisturizing to skin and hair and plays the effect of emollient when user is slept.This allows the benefit of the skin to dry position such as hand, ancon and foot or the moisturizing of hair, protection and skin moistening.It addition, this allows to provide those benefits for a long time.

Following sub-chapters and sections are more fully described the non-limiting aspect of the present invention.

The particular compound of the present invention is designed as moisture-keeping composition.Compositions depend on following component any one, its combination in any or its whole unique combination: vaseline, mineral oil, paraffin, hydrogenated soy glyceride, stearic acid, prickly-pear cactus fruit extract, Cera Flava, little candle tree (may ground lira) wax, babassu (Petiolus Trachycarpi) wax, Castor oil, Helianthi (sunflower) seed oil and wild soybean (Semen sojae atricolor) oil, spice and dyestuff.Compositions can also comprise one or more of composition described herein.Embodiment 1 table 1 provides the example of this compositions.

Can by above-mentioned composition application to skin or hair and stay for some time on skin or hair (such as, at least 1,2,3,4,5,10,20,30 or 60 minutes or longer time).After this, if it is desired, it is possible to compositions is washed away from skin or takes off from skin.

A. the amount of composition

Expect that compositions of the present invention can comprise the discussed composition of this specification of any amount.Compositions also can comprise the combination (such as, pigment or other cosmetics or ingredient) of any number of supplementary element described in this specification.Arbitrarily the concentration of composition can change in the composition.nullSuch as，In a not limiting embodiment，Compositions can comprise in its final form、Main by consisting of or by consisting of: such as at least about 0.0001%、0.0002%、0.0003%、0.0004%、0.0005%、0.0006%、0.0007%、0.0008%、0.0009%、0.0010%、0.0011%、0.0012%、0.0013%、0.0014%、0.0015%、0.0016%、0.0017%、0.0018%、0.0019%、0.0020%、0.0021%、0.0022%、0.0023%、0.0024%、0.0025%、0.0026%、0.0027%、0.0028%、0.0029%、0.0030%、0.0031%、0.0032%、0.0033%、0.0034%、0.0035%、0.0036%、0.0037%、0.0038%、0.0039%、0.0040%、0.0041%、0.0042%、0.0043%、0.0044%、0.0045%、0.0046%、0.0047%、0.0048%、0.0049%、0.0050%、0.0051%、0.0052%、0.0053%、0.0054%、0.0055%、0.0056%、0.0057%、0.0058%、0.0059%、0.0060%、0.0061%、0.0062%、0.0063%、0.0064%、0.0065%、0.0066%、0.0067%、0.0068%、0.0069%、0.0070%、0.0071%、0.0072%、0.0073%、0.0074%、0.0075%、0.0076%、0.0077%、0.0078%、0.0079%、0.0080%、0.0081%、0.0082%、0.0083%、0.0084%、0.0085%、0.0086%、0.0087%、0.0088%、0.0089%、0.0090%、0.0091%、0.0092%、0.0093%、0.0094%、0.0095%、0.0096%、0.0097%、0.0098%、0.0099%、0.0100%、0.0200%、0.0250%、0.0275%、0.0300%、0.0325%、0.0350%、0.0375%、0.0400%、0.0425%、0.0450%、0.0475%、0.0500%、0.0525%、0.0550%、0.0575%、0.0600%、0.0625%、0.0650%、0.0675%、0.0700%、0.0725%、0.0750%、0.0775%、0.0800%、0.0825%、0.0850%、0.0875%、0.0900%、0.0925%、0.0950%、0.0975%、0.1000%、0.1250%、0.1500%、0.1750%、0.2000%、0.2250%、0.2500%、0.2750%、0.3000%、0.3250%、0.3500%、0.3750%、0.4000%、0.4250%、0.4500%、0.4750%、0.5000%、0.5250%、0.0550%、0.5750%、0.6000%、0.6250%、0.6500%、0.6750%、0.7000%、0.7250%、0.7500%、0.7750%、0.8000%、0.8250%、0.8500%、0.8750%、0.9000%、0.9250%、0.9500%、0.9750%、1.0%、1.1%、1.2%、1.3%、1.4%、1.5%、1.6%、1.7%、1.8%、1.9%、2.0%、2.1%、2.2%、2.3%、2.4%、2.5%、2.6%、2.7%、2.8%、2.9%、3.0%、3.1%、3.2%、3.3%、3.4%、3.5%、3.6%、3.7%、3.8%、3.9%、4.0%、4.1%、4.2%、4.3%、4.4%、4.5%、4.6%、4.7%、4.8%、4.9%、5.0%、5.1%、5.2%、5.3%、5.4%、5.5%、5.6%、5.7%、5.8%、5.9%、6.0%、6.1%、6.2%、6.3%、6.4%、6.5%、6.6%、6.7%、6.8%、6.9%、7.0%、7.1%、7.2%、7.3%、7.4%、7.5%、7.6%、7.7%、7.8%、7.9%、8.0%、8.1%、8.2%、8.3%、8.4%、8.5%、8.6%、8.7%、8.8%、8.9%、9.0%、9.1%、9.2%、9.3%、9.4%、9.5%、9.6%、9.7%、9.8%、9.9%、10%、11%、12%、13%、14%、15%、16%、17%、18%、19%、20%、21%、22%、23%、24%、25%、26%、27%、28%、29%、30%、35%、40%、45%、50%、60%、65%、70%、75%、80%、85%、90%、95% or 99% or at least one composition mentioned in the whole text in specification and claims of wherein available any range.In non-limiting, percentage ratio can be calculated by the weight or volume of whole compositions.It will be recognized by one of ordinary skill in the art that the concentration in given compositions can change according to the interpolation of composition, replacement and/or minimizing.

B. supporting agent

The compositions of the present invention can be incorporated in all types of supporting agent.Limiting examples include emulsion (such as, Water-In-Oil, W/O/W, oil-in-water, water bag silicone, silicone Bao Shui, Water-In-Oil bag oil, the oil-in-water emulsion of silicone bag), cream, lotion, solution (aqueous solution or water-ethanol solution), anhydrous substrate (such as lipstick and powder), gel, facial film, tear off formula facial film and ointment.Change programme and other suitable supporting agent are it will be evident that and be applicable to the present invention for those of skill in the art.In some aspects, it is important that so that being combined as chemical compatibility and being formed without from end product the mode of complex of precipitation and select concentration and the combination of compound, composition and reagent.

C. supplementary element

Except the combination of composition disclosed in the present inventor, compositions can also comprise supplementary element, for instance cosmetic composition and active constituents of medicine.The limiting examples of these supplementary elements is described in following sub-chapters and sections.

1. cosmetic composition

CTFA international cosmetic ingredient dictionary and handbook (2004 and 2008) describe the multiple nonlimiting cosmetic composition that can use in the present case.nullThe example of these composition kinds includes: aromatic is (artificial and natural，Such as gluconic acid、Phenoxyethanol and triethanolamine)、Dyestuff and coloring components (such as blue No. 1、Blue No. 1 color lake、Red No. 28 color lakes、Yellow 5 color lake、Red No. 40、Titanium dioxide、Blue No. 4 of D&C、Green No. 5 of D&C、Orange No. 4 of D&C、Red No. 17 of D&C、Red No. 33 of D&C、D&C purple 2、D&C yellow 10 and D&C yellow 11)、Flavoring agent/flavouring agent is (such as，Folium Stevlae Rebaudianae (Steviarebaudiana) (dyeing mountain vitriol) extract and menthol) adsorbent、Lubricant、Solvent、Wetting agent (includes such as emollient、Wetting agent、Film former、Occlusive agent and the reagent affecting skin natural moisture preserving mechanism)、Water repellent、Ultraviolet absorber (physics and chemical absorbent，Such as Para-Aminobenzoic (" PABA ") and corresponding PABA derivant、Titanium dioxide、Zinc oxide etc.)、Quintessence oil、Vitamin (such as A、B、C、D、E and K)、Trace meter (such as zinc、Calcium and selenium)、Irritation thing (such as steroid and nonsteroidal anti-inflammatory)、Plant extract (such as Aloe、Citrus、Fructus Cucumidis sativi extract、Semen Ginkgo、Radix Ginseng and Herba Rosmarini Officinalis)、Antibacterial、Antioxidant (such as BHT and tocopherol)、Chelating agen (such as disodiumedetate and tetrasodium ethylenediamine tetraacetate)、Preservative (such as methyl parahydroxybenzoate and propyl p-hydroxybenzoate)、PH adjusting agent (such as sodium hydroxide and citric acid)、Absorbent (such as starch octenylsuccinic acid aluminum、Kaolin、Corn starch、Oat starch、Cyclodextrin、Talcum and zeolite)、Skin bleaching and brightener (such as hydroquinone and nicotiamide lactate)、Wetting agent (such as sorbitol、Carbamide、Methyl gluceth-20 and mannitol)、Exfoliation composition、Waterproofing agent (such as sodium hydroxide magnesium/aluminum stearate)、Skin conditioner (such as Aloe extract、Allantoin、Bisabolol、Ceramide、Polydimethylsiloxane、Hyaluronic acid、Biological carbohydrate gum-1、Sensiva SC50、Pentanediol、Hydrogenated polydecene、Octyl dodecanol oleate and glycyrrhizic acid dipotassium).In these compositions, the limiting examples of some provides in following sub-chapters and sections.

A. ultraviolet absorber

Chemically and physically substance having sun-screening function can be included with the ultraviolet absorber that the combination of compositions of the present invention uses.nullThe limiting examples of operable chemical sunscreen material includes para-amino benzoic acid (PABA)、PABA ester (PABA glyceride、Amyl group dimethanol PABA ester and octyl group dimethanol PABA ester)、PABA butyl ester、PABA ethyl ester、Ethyl dihydroxy propanol PABA ester、Benzophenone (oxybenzone、Sulisobenzone、Benzophenone and BP-1 are to BP-1 2)、Cinnamate/ester (octyl methoxycinnamate、Iso-amyl p-methoxycinnamate、Octyl methoxycinnamate、Cinoxate、Diisopropyl methyl cinnamate、Methoxy cinnamic acid DEA salt、Diisopropyl ethyl cinnamate、Glycerol caprylate dimethoxy-cinnamic acid ester and methoxycinnamate acetoacetic ester)、Cinnamate、Salicylate (equal cresotinic acid acid esters、Benzyl salicylate、Ethylene glycol salicylate、Isopropylbenzyl alcohol salicylate etc.)、Anthranilate/ester、Urocanic acid ethyl ester、Former film dissipates ester、Ethylhexyl salicylate、Dibenzoylmethane derivatives (such as avobenzone)、Octocrilene、Octyl triazone、Acyl acid trioleate、Glyceryl aminobenzoate、2-hydroxyl-1,4-naphthoquinone and dihydroxy acetone、Uvinul T 150、UVASORB HEB、Benzylidene malonic acid fat polydimethylsiloxane、Terephthalylidene dicamphor sulfonic acid、Phenyl dibenzimidazole tetrasulfonic acid ester disodium、Diethylamino-hydroxybenzoyl-hexyl-benzoate、Double; two diethylamino-hydroxybenzoyl benzoate、Double; two benzoxazolyl phenylethyl hexyl imino group triazines、Ethylhexysalicylate、Tinuvin 360 and double; two ethylhexyl oxy phenol anisyl triazine、4-methyl benzylidene camphanone and 4-methoxycinnamate isoamyl valerate.The limiting examples of physical sunblocks includes Kaolin, Talcum, vaseline and metal-oxide (such as titanium dioxide and zinc oxide).

B. wetting agent

The limiting examples of the wetting agent that can use together with the compositions of the present invention includes aminoacid, chondroitin sulfate, diglycerol, erythritol, fructose, glucose, glycerol, polyglycerine, ethylene glycol, 1, 2, 6-hexanetriol, Mel, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactose, maltose alcohol, maltose, mannitol, nature moisturizing factor, PEG-15 butanediol, polyglycereol sorbitol, the salt of 2-pyrrolidone-5-carboxylic acid, PCA potassium, propylene glycol, glucuronate sodium, Anjidew NL50, sorbitol, sucrose, trehalose, urea and xylitol.

nullOther examples include: acetylated lanolin、Acetylated lanolin alcohols.、Alanine、Algae extract、Aloe vulgaris (Aloebarbadensis)、Aloe vera extract、Aloe vera gel、Althaea officinalis L. (Altheaofficinalis) extract、Fructus Pruni (Prunusarmeniaca) core oil、Arginine、Arginine aspartate、Arnica montana (Arnicamontana) extract、Aspartic acid、Shea (American Avocado Tree，Perseagratissima) oil、Barrier sphingolipid、Butanol、Cera Flava、Docosanol、Cupreol、Betula platyphylla Suk. (Betulaalba) bark extract、Radix Arnebiae (Radix Lithospermi) (borage，Boragoofficinalis) extract、The Chinese blackbird belongs to Flos Caraganae Sinicae (butchers broom，Ruscusaculeatus) extract、Butanediol、Flos Inulae (Calendulaofficinalis) extract、Flos Inulae oil、(bearing ground lira) wax set by little candle、Oleum Brassicae campestris、Caprylic/capric triglyceride、Elettaria cardamomum (L.) Maton (Fructus Amomi Rotundus，Elettariacardamomum) oil、Brazil wax、Radix Dauci Sativae (Radix Dauci Sativae，Daucuscarotasativa) oil、Oleum Ricini、Ceramide、Ceresine、Cetearyl alcohol-5、Cetearyl alcohol-12、Cetearyl alcohol-20、Cetearyl octanoate、Ceteth-20、Ceteth-24、Cetyl acetate、Spermol caprylate、Spermol cetylate、Flos Chrysanthemi (Flos Matricariae chamomillae，Anthemisnobilis) oil、Cholesterol、Cholesteryl ester、Cholesteryl hydroxystearate、Citric acid、Salvia japonica Thunb. (salviasclarea) oil、Cocoa (theobromacacao) fat、Cocoanut oil alcohol-caprylate/decanoin、Cortex cocois radicis (cocosnucifera) oil、Collagen protein、Collagen, amino acid、Semen Maydis (zeamays) oil、Fatty acid、Ceraphyl 140、Dimethicone copolyol、Dimethiconol、Dioctyl adipate、Dioctyl succinate、Dipentaerythritol six caprylate/six decanoin、DNA、Erythritol、Ethoxydiglycol、Ethyl linoleate、Eucalyptus Globulus oil、Radix Oenotherae erythrosepalae (oenotherabiennis) oil、Fatty acid、Shametace oil、Glucamine、Glucose glutamate、Glutamic acid、Glycerin polyoxyethylene (26) ether、Glycerol、Glycerol、Distearin、Hydroxystearin、Glyceryl laurate ester、Glyceryl linoleate、Myristin、Olein、Tristerin、Tristerin SE、Glycine、Ethylene glycol stearic acid ester、Ethylene glycol stearic acid ester SE、Glucose glycosaminoglycan、Fructus Vitis viniferae (vitisvinifera) seed oil、Semen coryli heterophyllae (corylusamericana) macadamia nut oil、Hexanediol、Hyaluronic acid、Flos Carthami (carthamustinctorius) oil、Castor oil hydrogenated、Hydrogenated coco acid glyceride、Hydrogenated coconut oil、Hydrogenated lanolin、Hydrolecithin、Hydrogenated palm oil glycerides、Hydrogenated palm kernel oil、Oil with hydrogenated soybean、Hydrogenated tallow acid glyceride、Hydrogenated vegetable oil、Hydrolytic collagen、Elastin hydrolysis、Hydrolysis glucose glycosaminoglycan、Hydrolysis of keratin、Hydrolyzed soybean protein、Hydroxylated lanolin、Hydroxyproline、The different spermaceti alcohol ester of stearic acid、Different spermol stearyl stearate、Ceraphyl 140A、IPIS、Isopropyl lanolate、Isopropyl myristate、Isopropyl palmitate、Isopropyl stearate、Isostearoyl amine DEA、Isostearic acid、Isooctadecanol lactate、Isooctadecanol pivalate、Jasmine (jasminumofficinale) oil、Jojoba (buxuschinensis) oil、Macrocystis pyrifera (L.) Ag.、Candlenut tree (aleuritesmoluccana) macadamia nut oil、Lactamide MEA、Lanolin alcohol polyoxyethylene (16) ether、Lanolin alcohol polyoxyethylene (10) ether acetic acid ester、Lanoline、Lanoceric acid、Lanolin alcohol、Lanolin oil、Lanolin wax、Lavandula angustifolia (lavandulaangustifolia) oil、Lecithin、Fructus Citri Limoniae (citrusmedicalimonum) oil、Linoleic acid、Linolenic acid、Macadimia nut oil、Maltose alcohol、Flos Matricariae chamomillae (chamomillarecutita) oil、Methyl sesquistearate、Methyl-monosilane alcohol PCA、Mineral oil、Ermine oil、Mortierella oil、Myristyl alcohol lactate、Myristyl alcohol myristinate、Myristyl alcohol propionic ester、Neopentyl glycol dicaprylate/dicaprate、Octyldodecanol、Octyldodecanol myristinate、Octyldodecanol stearyl stearate、Octyl hydroxystearate、Octyl palmitate、Ethylhexyl salicylate、Octyl stearate、Oleic acid、Fructus Canarii albi (oleaeuropaea) oil、Orange (citrusaurantiumdulcis) oil、Petiolus Trachycarpi (elaeisguineensis) oil、Palmic acid、Pantethine、Pantothenylol、DL-Pantyl Ethyl Ether、Paraffin、PCA、Fructus Persicae (prunuspersica) core oil、Semen arachidis hypogaeae (arachishypogaea) oil、PEG-8C12-18 ester、PEG-15 cocoalkyl amines、PEG-150 distearate、PEG-60 iso stearic acid of glycerine ester、PEG-5 glyceryl stearate、PEG-30 glyceryl stearate、PEG-7 castor oil hydrogenated、Cremophor RH40、PEG-60 castor oil hydrogenated、PEG-20 methyl sesquistearate、The full oleate of PEG-40 anhydrous sorbitol、PEG-5 soyasterol、PEG-10 soyasterol、PEG-2 stearate、PEG-8 stearate、PEG-20 stearate、PEG-32 stearate、PEG-40 stearate、PEG-50 stearate、PEG-100 stearate、PEG-150 stearate、Pentadecanolide、Herba Menthae (menthapiperita) oil、Vaseline、Phospholipid、Amino acids polysaccharide condensation substance、Polyglycereol-3 diisopstearate、Polyquaternary ammonium salt-24、Polysorbate20、Polysorbate40、Polysorbate60、Polysorbate80、Polysorbate85、Potassium myristate、Potassium palmitate、Propylene glycol、Propylene/dicaprate、Propylene、Propylene glycol dipelargonate、Glycol laurate、Propylene glycol stearate、Propylene glycol stearate SE、PVP、Pyridoxine dipalmitate、Retinol、Retinyl palmitate、Rice (oryzasativa) rice oil、RNA、Herba Rosmarini Officinalis (rosmarinusofficinalis) oil、Oleum Rosae Rugosae、Flos Carthami (carthamustinctorius) oil、Salvia japonica Thunb. (salviaofficinalis) oil、Lignum Santali Albi (santalumalbum) oil、Serine、Serum albumin、Semen Sesami (sesamumindicum) oil、Shea (butyrospermum) fat、Silk Powder、Sodium chondroitin sulfate、Hyaluronate sodium、Sodium lactate、Sodium palmitate、Anjidew NL50、Polyglutamic acid sodium、Soluble collagen、Anhydrous sorbitol laurate、Sorbitan monooleate、Anhydrous sorbitol cetylate、Sorbitan sesquioleate、Span60、Sorbitol、Semen sojae atricolor (glycinesoja) oil、Sphingolipid、Squalane、Squalene、Stearmide MEA-stearate、Stearic acid、Stearoxy dimethicone、Stearoxyl trimethyl silane、Stearyl alcohol、Stearyl alcohol glycyrrhetin acid esters、Stearyl alcohol heptanoate、Stearyl Alcohol Stearic Acid ester、Helianthi (helianthusannuus) seed oil、Semen pruni armeniacae (prunusamygdalusdulcis) oil、Synthetic bees wax、Tocopherol、Tocopherol acetate ester、Vitamin E linoleate、Tribehenin essence、Tridecyl alcohol pivalate、Tridecyl alcohol stearate、Triethanolamine、Three sterins、Urea、Vegetable oil、Water、Wax、Semen Tritici aestivi (triticumvulgare) germ oil and fragrant cananga (canangaodorata) oil.

C. antioxidant

nullThe limiting examples of the antioxidant that can use together with the compositions of the present invention includes acetylcysteine、Ascorbyl polypeptide、Vitamin C dipalmitate、Ascorbic acid methyl-monosilane alcohol pectate、Ascorbyl palmitate、Ascorbyl stearate、BHA、BHT、Tertiary butylated hydroquinone、Cysteine、Cysteine HCI、Diamyl hydroquinone、Di-tert-butyl hydroquinone、Two spermol thiodipropionates、Two oil base tocopherol methyl silanols、Ascorbic acid sulfuric ester disodium、Distearyl alcohol thiodipropionate、Double; two tridecyl alcohol thiodipropionates、Dodecyl gallate、Arabo-ascorbic acid、Acid ascorbyl ester、Ferulic acid ethylester、Ferulic acid、Epicatechol gallate、Hydroquinone、Isooctyl thioglycolate、Kojic acid、Magnesium ascorbate、Magnesium L-ascorbyl-2-phosphate、Methyl-monosilane alcohol acid ascorbyl ester、Natural plant antioxidant such as green tea or Semen Vitis viniferae extract、Nordihydroguaiaretic acid、Gallateoctylester、Benzene TGA、Ascorbic acid 2-phosphate Renascin potassium、Potassium sulfite、Propylgallate、Quinone、Rosmarinic acid、Sodium ascorbate、Sodium sulfite、Sodium erythorbate、Sodium metabisulfite、Sodium sulfite、Superoxide dismutase、Sodium thioglycolate、Sorbitol furfural、Thiodiglycol、Sulfurous base diacetayl amide、Dimethylsulfide-.alpha..alpha.'-dicarboxylic acid、TGA、2-mercaptopropionic acid、Thiosalicylic acid、Tocopheryl polyethylene glycol (5) ether、Tocopheryl polyethylene glycol (10) ether、Tocopheryl polyethylene glycol (12) ether、Tocopheryl polyethylene glycol (18) ether、Tocopheryl polyethylene glycol (50) ether、Tocopherol、Holder can Soren、Tocopherol acetate ester、Vitamin E linoleate、Tocopheryl nicotinate、Tocopherol succinate and three (nonyl phenol) phosphite ester.

D. structural agent

In other is non-limiting, the compositions of the present invention can comprise structural agent.In some aspects, structural agent helps to provide rheological charactristics to contribute to the stability of compositions to compositions.In other side, structural agent could also function as the effect of emulsifying agent or surfactant.The limiting examples of structural agent includes stearic acid, Palmic acid, stearyl alcohol, spermol, behenyl alcohol, stearic acid, Palmic acid, has the polyglycol ether of the stearyl alcohol of average about 1 to about 21 ethylene oxy units, the polyglycol ether with the spermol of average about 1 to about 5 ethylene oxy units and mixture thereof.

E. emulsifying agent

In certain aspects of the invention, compositions does not comprise emulsifying agent.But, in other side, compositions can comprise one or more of emulsifying agent.Emulsifying agent can reduce phase interfacial surface tension and improve dosage form and the stability of emulsion.Emulsifying agent can be that non-ionic, cationic, anion and zwitterionic emulsifying agent are (referring to McCutcheon's (1986)；United States Patent (USP) 5,011,681；No. 4,421,769；No. 3,755,560).nullLimiting examples includes glyceride、Propylene glycol ester、The fatty acid ester of propylene glycol、The fatty acid ester of polypropylene glycol、The ester of sorbitol、Anhydrous sorbitol acid anhydride ester、Polymers of carboxylic acid、The ester of glucose and ether、The ester of ethoxylation、The alcohol of ethoxylation、Alkylphosphonate、Polyoxyethylene fatty ether phosphate ester、Fatty acid amide、Acyl lactylates、Soap、TEA stearate、DEA oleic alcohol polyoxyethylene ether-3 phosphate ester、Polyethylene Glycol 20 sorbitan mono-laurate (polysorbate20)、Polyethylene Glycol 5 soyasterol、Brij-721-2、Brij-721-20、Brij-721-21、Ceteareth-20、Cetearyl glucoside、Cetearyl alcohol、C12-13 Pareth-3、PPG-2 methyl glucose ether distearate、PPG-5-spermol polyoxyethylene ether-20、Double; two-PEG/PPG-20/20 polydimethylsiloxane、Spermol polyoxyethylene ether-10、Polysorbate80、Phosphoric acid monohexadecyl ester、Phosphoric acid monohexadecyl ester potassium、Diethanolamine Phosphoric acid monohexadecyl ester、Polysorbate60、Glyceryl stearate、PEG-100 stearate、Arachidic alcohol、Arachidic alcohol glucoside、And mixture.

F. the compound containing silicone

In non-limiting, the compound containing silicone include molecular backbone by silicon alternately basis set with the side being connected on the silicon atoms with oxygen atom become polymerizate family in any member.By the length of change-Si--O--chain, side base and crosslinking, silicone can synthesize various material.Their denseness can change to solid from liquid to gel.

The compound containing silicone that can use in the context of the present invention include described in this specification or known to persons of ordinary skill in the art those.Limiting examples includes silicone oil (such as volatility and nonvolatile oil), gel and solid.In specific, the compound containing silicone includes silicone oil, for instance polysiloxane.The limiting examples of polysiloxane includes the organosiloxane material of polydimethylsiloxane, Cyclomethicone, silicone-11, phenyl trimethicone, poly-trimethyl silicane amodimethicones, stearoxyl trimethyl silane or their mixture and other any given ratio, to reach desired denseness and application feature according to intended application (for example, to specific region such as skin, hair or eyes)." volatile silicone oils " includes the silicone oil with low heat of gasification, is namely usually less than about 50 every gram of silicone oil of card.The limiting examples of volatile silicone oils includes: Cyclomethicone, such as DOW CORNING 344 fluid, DOW CORNING 345 fluid, DOW CORNING 244 fluid and DOW CORNING 245 fluid, the volatilization silicon 7207 (Connecticut State, Danbury, Union Carbide Corporation)；Low viscosity polydimethylsiloxane, namely viscosity is approximately 50cst or less polydimethylsiloxane (for example, polydimethylsiloxane, for instance DOW CORNING 200-0.5cst fluid).DowCorningFluid can buy from the DowCorningCorporation of available.(being incorporated by reference into) in the third edition of CTFA cosmetic ingredient dictionary, Cyclomethicone and polydimethylsiloxane are described as cyclic dimethyl polysiloxane compound and the linear siloxane mixture of the exhaustive methylation with trimethyl siloxy units end-blocking respectively.Other the non-limiting volatile silicone oils that can use in the context of the present invention includes those buying of the SWSSiliconesDiv.ofStaufferChemicalCo. of GeneralElectricCo., the SiliconeProductsDiv. from New York Waterford and state of Michigan Adrian.

G. quintessence oil

Quintessence oil includes the oil from medicinal herbs, flower, trees and other plant.This kind of oil generally exists with drop small between plant cell, and can be undertaken extracting ((namely using fat-extraction), dipping, solvent extraction or mechanical expression are extracted in such as, steam distillation, the fragrance of a flower) by some methods well known by persons skilled in the art.When the oil of these types is exposed to air, it tends to volatilization (i.e. ethereal oil).Therefore, although many quintessence oils are colourless, but its oxidized and color becomes deeper over time.Quintessence oil is water insoluble, but is dissolved in alcohol, ether, fixing oil (plant) and other organic solvent.The general physical features found in quintessence oil includes the density of the boiling point from about 160 DEG C to 240 DEG C changes and from about 0.759 to about 1.096.

The originating species name that quintessence oil is found typically via oil.Such as, Oleum Rosae Rugosae or Oleum menthae are respectively from Flos Rosae Rugosae or mint plants.nullThe limiting examples of the quintessence oil that can use in the context of the present invention includes Oleum sesami、Macadimia nut oil、Tea tree oil、Radix Oenotherae erythrosepalae oil、Oil of Spanish sage、Spanish rosemary oil、Fructus Coriandri oil、Thyme oil、Many Oleum Linderae oil、Oleum Rosae Rugosae、Aniseed oil、Impatientis caul-fat、Oleum bergamottae、Rosewood oil、Cedar oil、Chamomile oil、Sage oil、Salvia Sclare L.oil、Oleum Caryophylli、Cedar oil、Oleum Eucalypti、Oleum Anisi Stellati、Seafennel oil、Olibanum oil、Oleum Pelargonii Graveolentis、Oil of ginger、Oil of grapefruit、Jasmin oil、Juniper berry oil、Oleum lavandula angustifolia、Fructus Citri Limoniae oil、Indian oil of verbena、Lime oil、Mandarin oil、Marjoram oil、Myrrha、Bitter orange flower oil、Orange oil、Patchouli oil、Oil of pepper、Fructus piperis nigrum oil、Petitgrain bigarade oil、Oleum Pini、Otto Rose oil、Oil of rosemary、Oleum Santali albi、Oleum menthae viridis、Radix Et Rhizoma Nardostachyos oil、Vetiver oil、Wintergreen oil、Ylang-ylang.It is also contemplated that other quintessence oil well known by persons skilled in the art is useful in the context of the present invention.

H. thickening agent

Include the thickening agent of thickening agent or gel, including the material that can increase compositions viscosity.Thickening agent includes increasing compositions viscosity and does not substantially change in compositions active component effect those.Thickening agent can also increase the stability of the compositions of the present invention.The present invention some in, thickening agent includes Parleam, trihydroxy stearin, AVC or their mixture.

The limiting examples of the other thickening agent that can use in the context of the present invention includes carboxylic acid polyalcohol, the polyacrylate polymers of crosslinking, polyacrylamide polymers, polysaccharide and glue.The example of carboxylic acid polyalcohol includes containing the cross-linking compounds of monomer of one or more of derived from propylene acid, the acrylic acid of replacement and acrylic acid salt of these acrylic acid and replacement and ester, wherein said cross-linking agent contains two or more carbon-to-carbon double bonds, and derived from polyhydric alcohol (referring to United States Patent (USP) 5,087, No. 445；No. 4,509,949；No. 2,798,053；CTFA international cosmetic ingredient dictionary, the 4th edition, the 1991, the 12nd and 80 page).The example of commercially available carboxylic acid polyalcohol includes carbomer, and it is that the acrylic acid homopolymer with the allyl ether crosslinking of sucrose or tetramethylolmethane is (such as, purchased from the Carbopol of B.F.Goodrich^TM900 series).

The limiting examples of the polyacrylate polymers of crosslinking includes cationic and non-ionic polyalcohol.United States Patent (USP) 5,100,660；No. 4,849,484；No. 4,835,206；No. 4,628,078；Example described in No. 4,599,379.

The limiting examples that polyacrylamide polymers (includes non-ionic polyacrylamide polymers, it includes replacing branching or nonbranched polymer) includes polyacrylamide, isoparaffin and lauryl alcohol polyethylene glycol oxide (7) ether, acrylamide and the segmented copolymer of acrylamide replaced by the acrylic acid of acrylic acid and replacement.

The limiting examples of polysaccharide includes cellulose, carboxymethyl hydroxyethyl cellulose, acetate propionate Carboxylic Acid Fibre element, hydroxyethyl cellulose, hydroxyethyl ethylcellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethylcellulose, microcrystalline Cellulose, cellulose sodium sulfate and mixture thereof.Other examples are the cellulose that alkyl replaces, wherein the hydroxyl of cellulosic polymer is by hydroxyalkylation (preferably hydroxyethylation or hydroxypropylation) to form the cellulose of hydroxyalkylation, and then it modifiied by ehter bond further with C10-C30 straight or branched alkyl group.These polymer general are the ether of C10-C30 straight or branched alcohol and hydroxy alkyl cellulose.Other useful polysaccharide includes scleroglucan class, and it comprises the straight chain of (1-3) that every three unit have the glucose that (1-6) the connects glucose unit connected.

The limiting examples of the operable glue of the present invention includes Radix Acaciae senegalis, agar, algin, alginic acid, ammonium alginate, branched starch, calcium alginate, calcium carrageenan, carnitine, carrageenin, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium ammonium chloride, Strese Hofmann's hectorite., hyaluronic acid, hydrated SiO 2, hydroxypropyl chitosan, hydroxypropyl guar gum, Indian tragacanth, Macrocystis pyrifera (L.) Ag., carob, natto gum, potassium alginate, carrageenin potassium, propylene glycol alginate, sclerotium gum, Sensor Chip CM 5 sodium, carrageenin sodium, Tragacanth, xanthan gum and mixture thereof.

I. preservative

The limiting examples of operable preservative includes quaternary ammonium salt preservative (such as polyquaternary ammonium salt-1 and benzalkonium halides (such as benzalkonium chloride (" BAC ") and benzalkonium bromide)), Nipagin ester (such as methyl parahydroxybenzoate and propyl p-hydroxybenzoate), phenyl phenol, benzylalcohol, methaform, phenol, sorbic acid, thimerosal or its combination in the context of the present invention.

2. ingredient

It is also contemplated that the compositions of the present invention is useful by active constituents of medicine.nullThe limiting examples of active constituents of medicine includes anti-acne agent、For processing the reagent of rosacea、Analgesic、Anesthetis、Anorectal、Antihistaminic、Include the antiinflammatory of non-steroidal anti-inflammatory medicine、Antibiotic、Antibacterial、Antivirin、Antimicrobial、β-elemene、Antiscabietic、Lousicide、Antineoplastic agent、Antiperspirant、Pruritus、Psoriasis medicine、Lipotropism bleeding、Biological activity protein and polypeptide、Burn inorganic agent、Cauterant、Decolorising agent、Depilatory、Diaper rash inorganic agent、Enzyme、Hair growth stimulant、Include the hair growth inhibitor of DFMO and salt thereof and analog、Hemorrhage、Keratolytic、Aphtha inorganic agent、Herpes labialis inorganic agent、Dentistry or periodontal inorganic agent、Photaesthesia active matter、Derma-Guard/barrier agent、Steroid including hormone and 17-hydroxy-11-dehydrocorticosterone、Sunburn inorganic agent、Opacifier、Percutaneous active matter、Nose active matter、Vagina active matter、Wart inorganic agent、Wound inorganic agent、Wound healing agent etc..D. cosmetics suit

It is also contemplated that cosmetics are set with some for the present invention determines aspect.Such as, the compositions of the present invention can include in cosmetics are set with.Cosmetics suit can include container.Container can include bottle, metal tube, laminated tube, plastic tube, allotter, high-pressure bottle, barrier container, packaging, locellus, Lipstick casing, compression container, the cosmetics dish that can preserve cosmetic composition or other type of container, the such as plastic containers of injection or blow molding, wherein preserve dispersion or compositions or desired bottle, allotter or packaging.Cosmetics suit and/or container can comprise labelling on its surface.For example, labelling can be words, phrase, abbreviation, picture or symbol.

Described container can distribute the compositions of scheduled volume.In other embodiments, it is possible to extruding container (such as metal, lamination or plastic tube) is with the compositions of allotment period desired amount.Compositions can be assigned as spraying, aerosol, liquid, fluid or semisolid.Container can have spraying, suction or pressing mechanism.Cosmetics suit can also comprise to be made apply some make up suit component and use the description of the compositions being arbitrarily contained in container.Description can include how to use, use and preserve the explanation of compositions.

Embodiment

Including following example so that the preferred embodiments of the invention to be described.It will be understood by those skilled in the art that technology disclosed in following example can represent the technology playing good action in the practice of the invention that the inventors discovered that, therefore, it is possible to think that it constitutes the preferred implementation for its practice.But, according to the disclosure, it will be understood by those skilled in the art that without departing from the spirit and scope of the present invention, many changes can be made in disclosed concrete solid yardage case, and still obtain same or analogous result.

Embodiment 1

The preparation preparation with the composition according to embodiment 1 is used or hair hair composition for local skin.The preparation preparation of table 1 is used or hair hair composition for skin.

Table 1 ^*

Composition	% concentration (by weight)
		Vaseline	60
Mineral oil	22
		Paraffin	8
Cera Flava	5.4
		Candelilla wax	2.2
Hydrogenated soy glyceride	1.5
		Spice	0.3
Brazil wax	0.2
		Stearic acid	0.2
Castor oil	0.2
		(optional) pigment/dye	0.1
Prickly-pear cactus fruit extract.	0.0005
		Excipient * *	In right amount

^*Preparation can by mixing described composition until uniformly preparing under heating at 70 DEG C to 75 DEG C in beaker.It is then possible to described preparation to be cooled to normal room temperature (20 to 25 DEG C).It addition, if desired, for instance supplementary element can be added to change the rheological behavior of compositions.

^***Such as can add excipient to change the rheological behavior of compositions.

Embodiment 2

(analysis)

The combination in any that can be used for determining the disclosed in full composition of specification and claims or composition can be determined by method known to persons of ordinary skill in the art or there is the analysis of the effect of any one of compositions of combination of described composition.The following is can use in the present case non-limiting.Will be appreciated that, it is possible to use other test process, including such as objective and subjective process.

B16 pigmentation is analyzed: melanogenesis is that melanocyte produces melanic process, and melanin is a kind of naturally-produced pigment giving skin, hair and eye color.Melanogenesis is suppressed to be of value to prevention skin darkening and alleviate and aging relevant black speck.This bioanalysis adopts B16-F1 melanocyte (ATCC), the mouse melanin tumor cell system of a kind of immortalization, carrys out the effect that melanocyte is produced by analysis of compounds.The terminal of this analysis is the spectrophotometry that melanin produces with cytoactive.Can at 37 DEG C the CO of 10%₂The middle hyclone (Mediatech) utilizing 10% cultivates B16-F1 melanocyte in standard DMEM growth medium, then processes 6 days by active component disclosed in this specification, the combination of composition or any one in having the compositions of described combination.After cultivation, secreted by the absorptiometry melanin at 405nm place, quantitative cytoactive.

Collagen protein stimulates to be analyzed: collagen protein is a kind of extracellular matrix protein that skin texture is crucial.The collagen protein synthesis increased helps improve skin firmness and elasticity.This bioanalysis can be used to detect active component disclosed in this specification, the combination of composition or there is the compositions of described combination in any one impact on the generation of the precollagen peptide (precursor of collagen protein) of human epidermal fibroblast.The terminal of this analysis is the spectrophotometry of existence and the cytoactive reflecting precollagen peptide.This analysis adopts quantitative sandwich Enzyme Immunoassay, therefore the monoclonal antibody that precollagen peptide is special is coated on microwell plate in advance.Can being pipetted in hole by standard substance and sample, all precollagen peptides existed are by immobilized antibodies.After washing away all unconjugated materials, add the enzyme connection polyclonal antibody that precollagen peptide is special to hole.Rinse with after removing all unconjugated antibody-enzyme reaction things, it is possible to substrate solution is added to hole, develop the color proportional to the amount of the precollagen peptide combined in initial step, use microplate reader to detect at 450nm place,.Colour developing can be stopped, and measure the intensity of color.Can by the CO of 10% at 37 DEG C₂Asia that the middle hyclone (Mediatech) utilizing 10% is cultivated in standard DMEM growth medium is merged the combination of normal human subject maturation epidermis fibroblast (CascadeBiologics) composition disclosed in this specification or has each of compositions of described combination and process 3 days.After cultivation, it is possible to collect cell culture medium, it is possible to use the amount of sandwich Enzyme Linked Immunoadsorbent Assay (ELISA) (#MK101) the quantitatively precollagen peptide secretion of Takara.

Tumor necrosis factor-alpha (TNF-α) is analyzed: the prototype part of TNF superfamily, TNF-α, be a kind of pleiotrophic cytokine played a major role in inflammation.The increase of its expression is relevant with proinflammatory activity rise.This bioanalysis can be used to analyze active component disclosed in this specification, the combination of composition or there is the compositions of described combination in any one impact on the generation of the Keratinocytic TNF-α of human epidermal.The terminal of this analysis is probably the existence of reflection TNF-α and the spectrophotometry of cytoactive.This analysis adopts quantitative sandwich Enzyme Immunoassay, therefore the monoclonal antibody that TNF-α is special is coated in advance on microwell plate.Can standard substance and sample be pipetted in hole, the antibodies that all TNF-α existed are immobilized.After washing away all unconjugated materials, it is possible to add the enzyme connection polyclonal antibody that TNF-α is special to hole.Rinse with after removing all unconjugated antibody-enzyme reaction things, it is possible to substrate solution is added to hole, develop the color proportional to the amount of the TNF-α combined in initial step, use microplate reader to detect at 450nm place.Colour developing can be stopped, and measure the intensity of color.Can by the CO of 5% at 37 DEG C₂In sub-normal human subject maturation horn cell (CascadeBiologics) phorbol-12-myristate-13-acetas (PMA merged that cultivates in the EpiLife standard growing media (CascadeBiologics), 10ng/ml, SigmaChemical, #P1585-1MG) and each process of active component disclosed in this specification, the combination of composition or the compositions with described combination process 6 hours.Having shown that PMA causes that TNF-α secretion significantly increases, described TNF-α secretion reaches peak value after processing 6 hours.After cultivation, it is possible to collect cell culture medium, and use the amount of sandwich Enzyme Linked Immunoadsorbent Assay (ELISA) the quantitatively TNF-α secretion from R&DSystems (#DTA00C).

Antioxidation (AO) is analyzed: disclosed composition, the combining or have the total antioxidant capacity of any one in the compositions of described combination of composition are measured in this explanations in external biological analysis.The described ability of antioxidant in sample that relies on of analyzing suppresses(2,2'-azino-bis--[3-ethylbenzthiazoline sulfonate salt]) is oxidized to by metahemoglobin·+.The antioxidant system of organism comprises enzyme, for instance superoxide dismutase, catalase and glutathion peroxidase；Macromolecule, for instance albumin, ceruloplasmin and ferritin；With a large amount of little molecules, including ascorbic acid, alpha-tocopherol, beta-carotene, reduced glutathion, uric acid and bilirubin.The sum of the antioxidant being derived from food in source represents the total antioxidant capacity of extracellular fluid.The cooperation of all different antioxidants provides the opposing reaction oxygen more higher than independent any individualized compound or the protection of nitrogen free radical invasion and attack.Therefore, total oxidation resistance can provide more relevant bio information compared with measuring the acquisition of independent component, because that takes into account the accumulative effect of all antioxidants existed in blood plasma and body fluid.In sample, antioxidant prevents ability and Trolox, the comparing of a kind of water solublity tocopherol anologs of ABTS oxidation, and carries out quantitatively with the molar equivalent of Trolox.The oxidation resistance cosmetics from CaymanChemical (Ann Arbor, Michigan, USA) can be used to be set with #709001 as the external biological analysis combining or having the total antioxidant capacity of any one in the compositions of described combination measuring composition disclosed in this explanations, composition.Scheme can carry out according to manufacturer's recommendation.The described antioxidant relied in sample of analyzing suppresses(2,2'-azino-bis--[3-ethylbenzthiazoline sulfonate salt]) is oxidized to by metahemoglobin·+.By the ability aoxidized of antioxidant prevention ABTS in sample and Trolox, comparing of a kind of water solublity tocopherol anologs, and can carry out quantitatively with the molar equivalent of Trolox.

ORAC analyzes: the active component disclosed in this specification, the oxygen-derived free radicals of any one absorption (or absorbance) ability (ORAC) of the compositions combining or having described combination of composition can also be analyzed by the antioxidant activity of this constituents of measurement or compositions.This analysis can quantitatively inhibited oxidation agent, for instance be known to result in the oxygen-derived free radicals of infringement cell (such as Skin Cell), movable degree and the time used.Active component disclosed in this specification, the ORAC value of any one of the compositions combining or having described combination of composition can be determined by method known to persons of ordinary skill in the art (referring to U.S. publication number 2004/0109905 and 2005/0163880；Cao et al. (1993), its full content is incorporated by reference into).In a word, the analysis that Cao et al. (1993) describes measures anti-oxidizing compounds and suppresses hydroperoxyl radical product AAPH B-phycoerythrin fluorescence (B-PE) the caused ability declined in test material.

Mushroom Tyrosinase activity analysis: in mammalian cell, tryrosinase is two steps of catalysis in the melanin biosynthesis from tyrosine (being polymerized with from dopachrome).Tryrosinase is arranged in melanocyte, and produces to give the melanin (fragrance naphtoquinone compounds) of skin, hair and eye color.Can by mushroom TYR enzyme (Sigma) active component disclosed in this specification each, the combination of composition or any one during there is the combination of described combination exist under or be absent from lower to its substrate L-Dopa (Fisher) cultivation.Chromogenesis can be assessed by color board reading at 490nm place.The suppression percentage ratio of mushroom TYR enzymatic activity can by calculating compared with untreated comparison, with determine test composition or its combination suppress purifying enzyme activity ability.The test suppression of extract and comparing of kojic acid (Sigma).

Matrix metal proteinase activity (MMP3；MMP9) analyze: external matrix metalloproteinase (MMP) inhibition analysis.MMP is extracellular protease, and it works at many normal and morbid state by wide substrate specificity.MMP3 substrate includes collagen protein, fibronectin splicing variants and laminin，LN；And MMP9 substrate includes collagen protein VII, fibronectin splicing variants and laminin，LN.The colorimetric drug discovery cosmetics for MMP3 (AK-400) and MMP-9 (AK-410) from BioMolInternational are used to be set with; this analysis design is for measuring the proteinase activity of MMP; use sulfur-bearing polypeptide as chromogenic substrate (Ac-PLG-[2-sulfydryl-4-methyl-pentanoyl]-LG-OC2H5) 5,6.The peptide bond of MMP cracking site is substituted by the thioester bond in sulfur-bearing polypeptide.This key is produced sulfydryl by MMP hydrolysis, it is with DTNB [5,5'-dithio double; two (2-nitrobenzoic acid), ellman's reagent] reaction generation 2-nitro-5-thiobenzoate, can carry out detecting by its absorbance at 412nm place (during at pH6.0 with higher than 7, ε=13600M-1cm-1).Any one in can analyzing the active component disclosed in this specification, the combination of composition or there is the compositions of described combination.

Cyclooxygenase (COX) is analyzed: external cyclooxygenase-1 and-2 (COX-1 ,-2) inhibition analysis.COX is a kind of bifunctional enzyme representing cyclooxygenase and peroxidase both activities.Arachidonic acid is converted to hydrogen peroxide endoperoxide (PGG2 by cyclooxygenase-2 activity；PGG2), peroxidase component is by endoperoxide (PGH2；PGH2) it is reduced to corresponding alcohol, the precursor of prostaglandin, thromboxane and prostacyclin.This COX suppresses the peroxidase component of screening strength measurement ring oxygenase.Peroxidase activity carries out colorimetric analysis by monitoring the appearance of N, N, N', the N'-TMPD (TMPD) of oxidation.This suppression screening strength includes both COX-1 and COX-2 enzymes, to screen isozyme specific inhibitor.Can use colorimetric COX (sheep) inhibitor screening analysis (#760111, CaymanChemical) analyze active component disclosed in this specification each, the combination of composition or there is the impact on the cyclooxygenase (COX-1 or COX-2) of purification of the compositions of described combination.Operation instruction according to manufacturer, pure enzyme, haemachrome and test extract can mix in analysis buffer, and at room temperature shake is cultivated 15 minutes.After cultivation, it is possible to add arachidonic acid and colorimetric substrates to start reaction.Color progress can be assessed at 590 nm by color board reading.The suppression percentage ratio of COX-1 or COX-2 activity can be calculated by comparing with untreated tester, to determine that test extract suppresses the ability of pure enzymatic activity.

Lipoxidase (LO) is analyzed: external lipoxidase inhibit analysis.LO is the dioxygenase of nonheme iron content, and its catalytic molecular oxygen adds to fatty acid.Linoleate/ester and arachidonate/ester are in plant and the main substrate of LO in animal.Then, arachidonic acid can be converted to hydroxyl tricosene (HETE) acid derivative, and it is subsequently converted to leukotriene, effective inflammatory mediator.This analysis provides method that is a kind of accurate and that be conveniently used for screening lipoxidase inhibitor by measuring the hydroperoxides utilizing the lipoxidase (5-, 12-or 15-LO) that arachidonic acid is cultivated to produce.Can use colorimetric LO inhibitor screening cosmetics suit (#760700, CaymanChemical) determine active component disclosed in this specification each, the combination of composition or there is the ability of any one inhibitory enzyme activity of compositions of described combination.Purified 15-lipoxidase and test composition can be mixed in analysis buffer, and at room temperature shake is cultivated 10 minutes.After cultivation, it is possible to adding arachidonic acid and start reaction, mixture at room temperature cultivates other 10 minutes again.Colorimetric substrates can be added to terminate catalysis, and assess color progress by fluorescent screen reading under 490nm.The suppression percentage ratio of activity of fatty oxygenase can be assessed compared with untreated comparison, with determine active component disclosed in this specification each, the combination of composition or there is the ability that any one of compositions of described combination suppresses the activity of purifying enzyme.

Elastoser is analyzed: can use MolecularProbes's (Eugene, Ore, USA)Elastoser analyze (cosmetics suit #E-12056) as measure active component disclosed in this specification each, the combination of composition or there is the vitro enzyme inhibition analysis of the elastase activity of any one suppression of compositions of described combination.EnzChek cosmetics suit is containing solvable cattle paxwax elastin laminin, and it can with dye marker so that conjugation fluorescence can be quenched.The substrate of non-fluorescence can by elastoser or other protease digestions to produce the fragment of high fluorescence.The Fluorescence Increasing produced can be monitored with fluorescence microplate analyzer.Digestion product from elastin substrate has absorption maximum at about 505nm place, has fluorescence emission maximum at about 515nm place.When using EnzChek elastoser to analyze cosmetics suit to screen elastase inhibitor, it is possible to peptide, chloromethyl ketone are used as selective, common elastase inhibitor.

Oil controls to analyze: can pass through use standard technique known to persons of ordinary skill in the art be analyzed for measuring the analysis of the minimizing that sebum produces in the minimizing of sebum secretion in sebaceous gland and/or sebaceous gland.In specific example, it is possible to use forehead.Can by each of active component disclosed in this specification, the combination of composition or there is any one once a day or twice ground of compositions of described combination be administered to the part of the forehead date one period fixing (such as 1,2,3,4,5,6,7,8,9,10,11,12,13,14 or more sky), and other parts of forehead need not described compositions-treated.The date one period fixing expire after, sebum secretion can pass through thin blotting paper is administered to processed with untreated forehead skin on be analyzed.This is by first using wet and dry cloth to complete from that processed and the untreated region all sebums of removal.Then blotting paper is administered to processed and untreated forehead region, it is possible to place rubber band to be pressed onto on skin by blotting paper lightly around forehead.After 2 hours, blotting paper can be removed so that it is dry, then carries out transillumination.More deep blotting paper is corresponding to more many sebum secretion (or the sebum secretion that shallower blotting paper is corresponding to reducing.

Erythema is analyzed: the analysis measuring skin rubefaction minimizing can use MinoltaChromometer to be estimated.Skin erythema can cause by using the sodium dodecyl sulfate solution of 0.2% at experimenter's forearm.The paster that this region is closed is protected 24 hours.After 24 hours, remove paster, it is possible to use a of MinoltaChromaMeter^*The value rubescent being estimated to stimulation initiation.a^*Value measures the colour of skin change at red area.After reading, process this region by active component disclosed in this explanation, the combination of composition or any one during there is the compositions of described combination immediately.Repeated measure can be periodically subject to determine that preparation reduces ability that is rubescent and that stimulate.

Moisture of skin/hydration analysis: the benefit of moisture of skin/hydration can by utilizing with the NovaDermalPhaseMeter impedance measurement carried out measurement.The change of skin moisture content measured by impedometer.Skin outer layer has different electrical properties.When xerosis cutis, its poor conductors.When it becomes more moisture, produce the electric conductivity increased.Therefore, Skin Resistance (with electric conductivity about) change may be used for evaluate skin hydration change.Device can illustrate to be calibrated for each test day according to instrument.Temperature and relative humidity can also be carried out labelling.Experimenter can be carried out assessment as follows: before measuring, it can be balanced having the indoor determining humidity (such as 30-50%) and temperature (such as 68-72 DEG C).Carry out three independent impedance measurings in every side of face, and it is recorded and on average.Impedometer can use T5 to set, and the resistance value being administered to every five seconds on the face is averaged by it.Change can be reported with statistical variance and significance.According to the method can analyze active component disclosed in this specification each, the combination of composition or any one during there is the compositions of described combination.

The analysis that the clear degree of skin and freckle and senile plaque reduce: the clear degree of skin and freckle and senile plaque reduce use MinoltaChromometer and be evaluated.The change of the colour of skin can use a of MinoltaChromaMeter^*Value is estimated determining owing to product treatment causes the probability of stimulation.a^*Value measures the colour of skin change at red area.This be used for determining in this explanations disclosed active component each, composition combine or have in the compositions of described combination any one whether cause stimulation.Measurement can carry out in every side of face and be averaged, as the value on the left side and the right face.The clear degree of skin can also use MinoltaMeter to measure.Measurement is a of MinoltaMeter^*, b and L-value combination, and relevant with the brightness of skin, and the smoothness of extraordinary corresponding skin and hydration.Skin measures executed as described above.In one non-limiting, the clear degree of skin can be described as L/C, and wherein C is colourity and is defined as (a²+b²)^1/2。

Xerosis cutis, surface fine crack, skin smoothness and skin analysis: xerosis cutis, surface fine crack, skin smoothness and the colour of skin can be estimated by clinical score technology.Such as, xerodermatic clinical score can be determined by 5 standard K ligmanscale: (0) skin is soft and moistening；(1) skin presents normal without visible dry；(2) skin touch perception is slightly dry without visible peeling；(3) dermal sensation dry, tough and tensile and there is the outward appearance turned white of some squama；And (4) dermal sensation is very dry, coarse and has the scaly outward appearance turned white.Assessment can independently be carried out by two clinicists and be averaged.

Colour of skin clinical score is analyzed: the clinical score of the colour of skin can pass through 10 simulation value scales and implement: the uniform skin that (10) smooth, pink brown color.Hand magnifier does not have speckle that is dark, rubescent or that have squama when checking.The Micro texture of skin feels highly uniform；(7) the uniform colour of skin is observed without magnifier.There is no squamous region, but have the rash speckle owing to pigmentation or erythema cause.There is no the diameter rash speckle more than 1cm；(4) skin rash speckle and uneven texture it are readily noticed that.A small amount of scale.Some region feels rough skin；And (1) uneven dye and texture.The scale in multiple regions and rash speckle, hypopigmented, rubescent or black speckle.The large-area diameter spotty staining more than 1cm.Assessment is independently carried out by two clinicists and is averaged.

The clinical score analysis of skin smoothness: the clinical score of skin smoothness can be analyzed by 10 simulation value scales: (10) are smooth, skin is moistening and flash of light, and finger does not have resistance when streaking surface；(7) to a certain degree smooth, small resistance；(4) coarse, change visibly, have frictional force during friction；And the surface that (1) is coarse, lamellar, uneven.Assessment is independently carried out by two clinicists and is averaged.

The analysis that the skin smoothness undertaken by method disclosed in Packman et al. (1978) and wrinkle reduce: the minimizing of skin smoothness and surrounding can also by using method disclosed in Packman et al. (1978) to carry out visualization assessment.Such as, when each experimenter goes to a doctor, the degree of depth of surface upper thread (SFL) of each experimenter, either shallow and total quantity be can be carried out conscientious scoring and record.The mark of numeral is obtained by Quantitative factor being multiplied by depth/width/length factor.Obtain the mark on eye areas and face region (left side and right side), added together as total wrinkle mark.

With the HargensBallistometer skin tightness analysis carried out: skin tightness can use HargensBallistometer, a kind of by falling next wisp record the first two bounce-back peak and assess the device of skin elasticity and degree of compacting on skin, measure.Ballistometry is the little light weight detector using relatively blunt probe (4 square millimeters-contact area).Detector penetrates into skin lightly, causes the measurement depending on skin outer layer character, and described skin outer layer includes horny layer and exocuticle and some dermis layer.

With the GasBearingElectrodynamometer skin emolliency carried out degree/pliability analysis: skin emolliency degree/pliability can use GasBearingElectrodynamometer, a kind of instrument measuring skin pressure/tensile properties, is estimated.The viscoelasticity of skin is relevant with skin moisture-keeping.The measurement to cheek region specific site can be realized by detector being attached to skin surface with double faced adhesive tape.The power of about 3.5gm is parallel puts on skin surface, accurately measures the displacement of skin.Then can calculate the pliability of skin, and be expressed as DSR (Dynamic Spring rigidity, in gm/mm).

The lines that carry out with copy and wrinkle manifest analysis: on skin, lines and manifesting of wrinkle can use copy to be estimated, and described copy is the die of skin surface.The material such as silicone rubber can be used.Copy can be analyzed by graphical analysis.The change of lines and wrinkle observability can be passed through to utilize silicon copy form the face of experimenter and carry out quantitative objectively with Computer digital image analysis analysis copy image.Copy can obtain from eye areas and neck area, and shoots with low illumination incident angle with digital camera.Digital picture can be analyzed and determine the region that copy is covered by wrinkle and microgroove with image processing program.

The skin surface contours analysis undertaken by the method for talysurf/recording needle: skin surface contours can pass through to use the method measurement of talysurf/recording needle.This includes flash of light or drags recording needle through copy surface.The vertical displacement of recording needle by range sensor can input computer, scanning copy certain distance after, the analysis of contoured skin can produce with Two-dimensional Surfaces.This scanning can repeat arbitrary number of times to produce the skin 3-D image of simulation along fixing axle.Use recording needle technology can obtain ten random copy cross sections, and combine generation meansigma methods.Value interested includes Ra, and it is the arithmetical average by integration all roughness (highly) values calculated relative to the profile elevations h of draw profile elevations h.Rt, it is the maximum normal distance between summit and lowest trough, and Rz, and it deducts average peak height for average peak amplitude.Numerical value is to provide with the numerical value demarcated in units of mm.Equipment should be standardized by the metal master thing of scanning known numeric value before every use.Ra value can be calculated by following formula: R_a=standardization roughness；l_m=horizontal (scanning) length；And y=outline position is relative to the absolute value (x-axle) of mean profile height.

MELANODERM^TMAnalyze: in other are non-limiting, the active component of this disclosure, composition combination or have described combination compositions the effect of any one can pass through use Skin equivalent, for instance MELANODERM^TMIt is estimated.Melanocyte, the one of cell in Skin equivalent, pollute clearly when being exposed to L-DA (L-DOPA) i.e. melanic precursor.Skin equivalent MELANODERM^TMCan with various containing the active component disclosed in this specification each, the substrate of any one of the combination of composition or the compositions with described combination processes, or only uses the substrate as tester to process.Or, untreated Skin equivalent sample can serve as tester.

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Namely disclosed herein and claimed all compositionss and/or method inappropriate experiment need not can be made and realize according to the disclosure.Although the compositions and methods of the invention are described according to a preferred embodiment, can to described compositions and/or method and implement change in the step of method described herein or the order of step but it will be apparent to those skilled in the art that when without departing from idea of the invention, spirit and scope.More specifically, it is evident that some reagent that chemistry and physiology two aspect are all correlated with can substitute reagent described herein, can obtain same or analogous result simultaneously.All the obvious this kind of similar replacement of those skilled in the art and change are considered as in the spirit of the present invention as defined by the appended claims, scope and concept.

List of references

There is provided exemplary process or other subsidiary details to details set forth herein to a certain extent below with reference to document, they are expressly incorporated into herein.

CosmeticIngredientDictionary, the third edition, CTFA, 1982

InternationalCosmeticIngredientDictionary, the 4th edition, CTFA, 1991

InternationalCosmeticIngredientDictionaryandHandbook, the tenth edition, CTFA, 2004

InternationalCosmeticIngredientDictionaryandHandbook, the 12nd edition, CTFA, 2008

Claims

1. a moisture-keeping cosmetics compositions, it comprises:

Vaseline；

Mineral oil；

Paraffin；

Hydrogenated soy glyceride；

Stearic acid；With

Prickly-pear cactus fruit extract.

2. cosmetic composition according to claim 1, wherein said compositions comprises:

The vaseline of 25 weight % to 75 weight %；

The mineral oil of 10 weight % to 50 weight %；

The paraffin of 1 weight % to 15 weight %；

The hydrogenated soy glyceride of 0.5 weight % to 5 weight %；

The stearic acid of 0.1 weight % to 1 weight %；With

The prickly-pear cactus fruit extract of 0.0001 weight % to 0.01 weight %.

3. cosmetic composition according to claim 1, it is also included as the supplementary element of mixture of wax or wax.

4. cosmetic composition according to claim 3, wherein the described supplementary element for wax is selected from:

Cera Flava；

Candelilla wax；With

Brazil wax.

5. cosmetic composition according to claim 3, wherein for the described supplementary element of mixture of wax comprise following at least two:

Cera Flava；

Candelilla wax；With

Brazil wax.

6. cosmetic composition according to claim 5, wherein said compositions comprises:

The Cera Flava of 1 weight % to 10 weight %；

The candelilla wax of 1 weight % to 10 weight %；With

The Brazil wax of 0.1 weight % to 10 weight %.

7. cosmetic composition according to claim 1, it is also included as the supplementary element of mixture of oil or oil.

8. cosmetic composition according to claim 7, wherein the described supplementary element for oil is selected from:

Castor oil；

Sunflower seed oil；With

Wild soybean (Semen sojae atricolor) oil.

9. cosmetic composition according to claim 7, wherein for the described supplementary element of mixture of oil comprise following at least two:

Castor oil；

Sunflower seed oil；With

Wild soybean (Semen sojae atricolor) oil.

10. cosmetic composition according to claim 9, wherein said compositions comprises:

The Castor oil of 0.01 weight % to 1 weight %；

The sunflower seed oil of 0.01 weight % to 1 weight %；With

Wild soybean (Semen sojae atricolor) oil of 0.00001 weight % to 1 weight %.

11. cosmetic composition according to claim 1, it also comprises spice.

12. cosmetic composition according to claim 11, wherein said compositions comprises the spice of 0.1 weight % to 3 weight %.

13. cosmetic composition according to claim 1, it also comprises dyestuff.

14. cosmetic composition according to claim 13, wherein said compositions comprises the dyestuff of 0.01 weight % to 1 weight %.

15. cosmetic composition according to claim 1, wherein said compositions is anhydrous.

16. cosmetic composition according to claim 1, wherein said compositions is configured to make the skin of object or hair moisten.

17. cosmetic composition according to claim 16, wherein said compositions is configured to can stay on skin or the hair of object.

18. cosmetic composition according to claim 17, wherein said compositions is configured to stay when object is slept on skin or the hair of object.

19. a cosmetics suit, it includes the container of the moisture-keeping cosmetics compositions described in claim 1 and the moisture-keeping cosmetics compositions can held described in claim 1.

20. cosmetics according to claim 19 are set with, wherein said cosmetics suit also includes for the moisture-keeping cosmetics compositions described in claim 1 is applied to the skin of object or the operation instruction of hair, and wherein said operation instruction includes making described compositions retain less than one hour on skin or hair, be retained on skin or hair more than one hour and/or when object is slept.