WO2018077312A1 - 一种增强免疫力的泡腾片及其制备方法 - Google Patents

一种增强免疫力的泡腾片及其制备方法 Download PDF

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WO2018077312A1
WO2018077312A1 PCT/CN2017/114292 CN2017114292W WO2018077312A1 WO 2018077312 A1 WO2018077312 A1 WO 2018077312A1 CN 2017114292 W CN2017114292 W CN 2017114292W WO 2018077312 A1 WO2018077312 A1 WO 2018077312A1
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parts
extract
flower
effervescent tablet
total weight
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PCT/CN2017/114292
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English (en)
French (fr)
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黄爱强
钟文
黄爱毅
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广西圣保堂健康产业股份有限公司
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Publication of WO2018077312A1 publication Critical patent/WO2018077312A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Definitions

  • the invention belongs to the field of medicines, health foods and foods, and relates to a composition preparation and a preparation method thereof, in particular to an effervescent tablet for enhancing immunity and a preparation method thereof.
  • the traditional Chinese medicines of "medicine and food homologous" and some fruits with health effects are in line with people's treatment of diseases and health care needs.
  • the invention adds a suitable "medicine and food homologous" traditional Chinese medicine and a fruit with excellent health care effect on the basis of western medicine, and forms an effervescent tablet for enhancing immunity, the effervescent tablet is rich in nutrients and improves the human body.
  • Healthy active ingredients which have the functions of enhancing immunity, clearing away heat and detoxifying, replenishing the kidney and strengthening the spleen, and improving beauty and beauty. They can also supplement the nutrients needed by the human body, relieve fatigue and delay aging, especially for the health and beauty of the elderly and anti-aging. And the rehabilitation of cancer patients with low immunity.
  • Vitamin C is a commonly used drug or nutritional supplement in the clinic. It is one of the antioxidant vitamins. It is involved in the hydroxylation reaction in the body and is necessary for the formation of bone, tooth, connective tissue and non-epithelial cells. The normal function of bones and blood vessels, increase the resistance to disease, and is one of the essential nutrients for the human body. It is widely used in the prevention and treatment of various diseases. Vitamin C sodium is the sodium salt of vitamin C. The pH of the aqueous solution is close to neutral. It has the same effect as vitamin C, but because it is sodium salt, the performance is more stable. At the same time, there is no longer strong acidity of vitamin C. The drug is taken at the same time, which is better than vitamin C.
  • Effervescent tablets are a novel tablet developed and applied abroad in recent years. The difference between it and ordinary tablets is that it also contains an effervescent disintegrant.
  • effervescent tablet When the effervescent tablet is placed in drinking water, under the action of the effervescent disintegrant, a large amount of air bubbles are generated immediately, so that the tablet is quickly formed. Disintegration and melting, sometimes the bubbles generated by disintegration also cause the tablets to roll up and down in the water, accelerating their disintegration and melting. The gas generated when the tablet disintegrates is partially dissolved in the drinking water, so that the drinking water has a soda-like beauty when it is drunk in the mouth.
  • Effervescent tablets have the following advantages: easy to store and carry; rapid disintegration, convenient taking, rapid onset; high bioavailability, can improve clinical efficacy; especially suitable for children, the elderly and patients who have difficulty swallowing pills; After the seasoning of the effervescent tablets, the taste is better, the medicine is no longer bitter, so that consumers or patients are more willing to accept.
  • the invention aims at the acidity of the existing vitamin C-containing effervescent tablet after dissolution, the stimulation to the oral cavity, the throat esophagus and the gastric mucosa is large, and it is not suitable for long-term administration, and the vitamin C is easily oxidized and failed during storage, and the effervescent tablet is easy to absorb moisture and causes the tablet. Poor disintegration And other issues, provide an effervescent tablet that enhances immunity and has the effects of clearing heat and detoxifying, tonifying kidney and strengthening spleen, beauty and beauty, and the preparation method thereof, and solving the problems of unstable quality and difficulty in long-term use of vitamin C in clinical application. .
  • the effervescent tablet with enhanced immunity of the invention has the advantages of safe, non-toxic side effects, long-term use for improving the immunity and the health and beauty of the middle-aged and the elderly, and anti-aging; or long-term use as a nutritional supplement.
  • An immunostimulating effervescent tablet comprising the following components by weight: 50-200 parts of vitamin C sodium, 10-30 parts of taurine, 10-30 parts of zinc gluconate, 10-20 parts of flower and fruit extract .
  • the flower and fruit extract described above is made of the following raw materials by weight: 30-50 parts of medlar, 30-60 parts of fresh mulberry, and 5-10 of fresh grapes.
  • the preparation method of the above flower and fruit extract is as follows:
  • the extraction method under the step S2 is preferably heated reflux extraction and ultrasonic extraction.
  • the drying method under the step S4 is preferably oven heating drying and spray drying.
  • the above-mentioned immunostimulating effervescent tablet preferably further comprises the following components by weight: 50-120 parts of tartaric acid, 50-130 parts of sodium hydrogencarbonate, and 10-30 parts of aspartame.
  • the above-mentioned immunostimulating effervescent tablet further preferably further comprises 0.5 to 1.0% of trehalose and 0.3 to 0.5% of lactose based on the total weight of the above components.
  • the above-mentioned immunostimulating effervescent tablet preferably comprises the following components by weight: 120 parts of vitamin C sodium, 20 parts of taurine, 20 parts of zinc gluconate, 15 parts of flower and fruit extract, and tartaric acid 80.
  • the fraction, 90 parts of sodium hydrogencarbonate and 20 parts of aspartame also include trehalose in an amount of 0.8% by weight based on the total weight of the above components and lactose in an amount of 0.4% by weight based on the total weight of the above components.
  • the flower and fruit extract described above is made of the following raw materials in parts by weight: 40 parts of medlar, 50 parts of fresh mulberry, and 8 parts of fresh grapes.
  • the preparation method of the above-mentioned immune-enhancing effervescent tablet comprises the following steps:
  • T1 Preparation of flower and fruit extract: Weigh the following raw materials by weight: 30-50 parts of densely scented flowers, 30-60 parts of fresh mulberry, 5-10 parts of fresh grapes; take the weighed flowers, add 6 -10 times the amount of water, soak for 30 minutes, extract 2-3 times, each time 30-40 Minutes, filtered, get flower extract; take fresh mulberry and fresh grapes, wash, extract raw juice, filter, get juice; mix flower tea extract with juice, concentrate under 80 °C under reduced pressure, get a flow extract having a relative density of 1.18-1.22 at 60 ° C, the flow extract is dried, and the drying temperature is controlled to be 65-80 ° C to obtain an extract of flower and fruit;
  • T2 Weigh the following components by weight: 50-200 parts of vitamin C sodium, 10-30 parts of taurine, 10-30 parts of zinc gluconate, 10-20 parts of flower and fruit extract, 50-120 parts of tartaric acid, 50-130 parts of sodium hydrogencarbonate, 10-30 parts of aspartame; further weigh 0.5-1.0% of the total weight of the component of trehalose and 0.3-0.5% of the total weight of the component;
  • T3 Take 1/2 of the total weight of tartaric acid, flower and fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 50-60% ethanol solution, mix, granulate, sieve , dry, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate, flower and fruit extract, 1/2 of the total weight of trehalose, mix, spray 50-60% ethanol solution, mix, granulate, sieve, dry, Whole grain, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.
  • the drying temperature in the step T3, T4 is preferably 80 ° C or less, so that the obtained particles have a moderate hardness, which is more favorable for tableting, and utilizes disintegration; and the screening step described in the steps T3 and T4 is used.
  • the screen is preferably 14-30 mesh.
  • the invention overcomes the problem that the existing vitamin C-containing effervescent tablet has high acidity after dissolution, is irritating to the oral cavity, throat esophagus and gastric mucosa, and is not suitable for long-term use, and the vitamin C is easily oxidized and failed during storage, and the effervescent tablet is easy to absorb moisture and damp.
  • Such problems make the product more stable, more effective, suitable for long-term use by consumers or patients, no side effects.
  • the raw materials of the flower and fruit extract of the present invention are all "medicine and food homologous" varieties and daily edible fruits, and have safe and non-toxic side effects.
  • Mi Menghua sweet, slightly cold, return to the liver, contains a variety of amino acids, vitamins, trace elements, flavonoids and their glycosides, triterpenoid saponins, yellow pigment and other ingredients, can clear the liver fire, nourish the liver and moisten, And the eyes are retired; mulberry, sweet, cold, rich in active protein, vitamins, amino acids, carotene, minerals, flavonoids and other active ingredients, enhance human immunity, nourish the skin, delay aging, Shengjin It is called “folk fruit” because it quenches thirst, promotes digestion, nourish liver and kidney, nourish yin and blood.
  • Grapes contain a variety of minerals, vitamins and amino acids needed by the human body. They have anti-aging, fatigue and health. The spleen and stomach, prevention of blood clots, relief of hypoglycemia, etc., due to its high nutritional value, grape juice is praised by scientists as “plant milk”; the above three raw materials, through reasonable preparation, fragrant smell, good taste, enhance immunity, heat detoxification It can also replenish the kidneys, strengthen the spleen, and enhance the beauty and beauty. It can also supplement the nutrients needed by the body, relieve fatigue, delay aging, especially for the health and beauty of the elderly. And rehabilitation immunocompromised cancer patients.
  • the effervescent tablet with enhanced immunity of the invention has simple preparation, good fluidity of particles, and no sticking of the tablet, and the prepared tablet has a smooth surface, is not easy to absorb moisture, has uniform effervescent gas, and has a short disintegration time and collapse. After solution, the solution is transparent and clear, the taste is sweet, the quality is stable, and the carrying is convenient. It has the characteristics of solid preparation and liquid preparation, especially suitable for children, the elderly and can not swallow. Patients with solid preparations have high bioavailability, are safer and more effective to use, and can be taken as a nutritional supplement for a long time.
  • the word "preferred" and variants refers to embodiments of the invention that are capable of providing a particular benefit in a particular environment. However, other embodiments may be preferred under the same or other circumstances. In addition, the detailed description of one or more preferred embodiments does not indicate that other embodiments are useless and are not intended to exclude other embodiments from the scope of the invention.
  • the acid sources commonly used in effervescent tablets are tartaric acid, citric acid, fumaric acid, adipic acid, malic acid, etc.; alkali sources include sodium hydrogencarbonate, potassium carbonate, potassium hydrogencarbonate, calcium carbonate and the like.
  • the effervescent tablet prepared by using sodium hydrogencarbonate as an alkali source can rapidly disintegrate in water, and the pH of the effervescent solution is suitable for the stabilization of vitamin C sodium, so the alkali source of the present invention selects sodium hydrogencarbonate.
  • the selection test of tartaric acid, citric acid, fumaric acid, malic acid and adipic acid is carried out according to the formula in Table 1 to determine the best acid source in the effervescent tablet. kind.
  • the present invention uses tartaric acid mixed with vitamin C sodium, sodium hydrogencarbonate and aspartame, and is good for granulation, the lapse of disintegration time is short, the solution is clear, the mouthfeel is good, but it is sticky when tableting.
  • the rushing phenomenon is better than other acid sources, so the acid source of the present invention selects tartaric acid, and the alkali source selects sodium hydrogencarbonate.
  • the invention compares the dry pressing tablet, the wet granulation and the re-pulling, the dry pressing tablet adopts the ordinary tableting machine has a poor effect and has high requirements on the equipment, so the invention adopts the wet granulation and the tableting.
  • 30% starch slurry, 40% sucrose syrup, 5% hypromellose aqueous solution, and 55% ethanol were used as binders. The results are shown in Table 2.
  • Vitamin C sodium is the sodium salt of vitamin C. Its performance is more stable than vitamin C, but it is prepared into effervescent tablets. In the acid, alkali, other auxiliary materials and the influence of moisture and oxidation in the air, it is necessary to guarantee the product during the shelf life. The quality is stable and it is still necessary to add stabilizers. In the test, 0.02% EDTA disodium, 1% trehalose, and 0.2% sodium sulfite were compared. The samples prepared by the above stabilizers were respectively packaged with aluminum-plastic composite film, and the stability was accelerated in the test chamber: temperature: 40 ⁇ 2°C, relative humidity: 75 ⁇ 5%, accelerated test for 3 months, the test results are shown in Table 4.
  • the material before the tableting of the invention has acid agent, sodium vitamin C, sweetener and alkali agent, and the particle size and texture of the material are uneven. When the tablet is pressed, the particle flowability is poor, and the tablet is easy to stick and punch.
  • the formulas except the lubricant are the same, and after the preliminary test is used to determine the available ratio, the different amounts of the dodecyl magnesium sulfate, lactose, mannitol, and the samples prepared by using the above lubricants are specifically compared. They are packaged with aluminum-plastic composite film respectively, and the stability test is accelerated in the test chamber: temperature: 40 ⁇ 2°C, relative humidity: 75 ⁇ 5%, accelerated test for 3 months, and the results are shown in Table 6.
  • the method for preparing an immunostimulating effervescent tablet comprises the following steps:
  • T1 Preparation of flower and fruit extract: Weigh the following raw materials by weight: 40 parts of densely scented flowers, 50 parts of fresh mulberry, and 8 parts of fresh grapes; take the weighed flowers, add 8 times of water, soak 30 Minutes, heated and refluxed for 3 times, each time for 30 minutes, filtered, to obtain flower extract; take fresh mulberry, fresh grapes, wash, extract raw juice, filter, get juice; flower extract and The juice is mixed and concentrated under reduced pressure at 80 ° C or lower to obtain a flow extract having a relative density of 1.20 at 60 ° C, and the flow extract is sprayed. Drying the mist, controlling the drying temperature to 70 ° C, and obtaining the flower and fruit extract;
  • T2 Weigh the following components by weight: 120 parts of vitamin C sodium, 20 parts of taurine, 20 parts of zinc gluconate, 15 parts of flower and fruit extract, 80 parts of tartaric acid, 90 parts of sodium hydrogencarbonate, aspartame 20 parts; further weigh 0.5% of the total weight of the components of trehalose and 0.3% of the total weight of the components of lactose;
  • T3 Take 1/2 of the total weight of tartaric acid, flower and fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 55% ethanol solution, mix, granulate, pass 20 mesh sieve Dry at 80 ° C, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate, flower and fruit extract, 1/2 of the total weight of trehalose, mix, spray 55% ethanol solution, mix, granulate, pass 20 mesh sieve, 80 ° C Drying, granules, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.
  • the method for preparing an immunostimulating effervescent tablet comprises the following steps:
  • T1 Preparation of flower and fruit extract: Weigh the following raw materials by weight: 30 parts of densely scented flowers, 30 parts of fresh mulberry, 5 parts of fresh grapes; take the weighed flowers, add 6 times of water, soak 30 Minutes, ultrasonic extraction 3 times, each time 30 minutes, filtered, to obtain flower extract; take fresh mulberry, fresh grapes, wash, extract the original juice, filter, get juice; flower extract and juice Mixing, concentrating under reduced pressure at 80 ° C or lower to obtain a flow extract having a relative density of 1.18 at 60 ° C, spray-driing the flow extract, and controlling the drying temperature to 80 ° C to obtain an extract of flower and fruit;
  • T2 Weigh the following components by weight: 50 parts of vitamin C sodium, 10 parts of taurine, 10 parts of zinc gluconate, 10 parts of flower and fruit extract, 50 parts of tartaric acid, 50 parts of sodium hydrogencarbonate, aspartame 10 parts; further weigh 0.5% of the total weight of the component of trehalose and 0.3% of the total weight of the component of lactose;
  • T3 Take 1/2 of the total weight of tartaric acid, flower and fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 50% ethanol solution, mix, granulate, pass 30 mesh sieve Dry at 80 ° C, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate, flower and fruit extract, 1/2 of the total weight of trehalose, mix, spray 50% ethanol solution, mix, granulate, pass 30 mesh sieve, 80 ° C Drying, granules, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.
  • the method for preparing an immunostimulating effervescent tablet comprises the following steps:
  • T1 Preparation of flower and fruit extract: Weigh the following raw materials by weight: 50 parts of densely scented flowers, 60 parts of fresh mulberry, 10 parts of fresh grapes; take a good amount of densely scented flowers, add 10 times of water, soak 30 Minutes, heated and refluxed for 2 times, each time for 40 minutes, filtered, to obtain flower extract; take fresh mulberry and fresh grapes, wash, extract raw juice, filter, get juice; flower extract and The juice is mixed and concentrated under reduced pressure at 80 ° C or lower to obtain a flow extract having a relative density of 1.22 at 60 ° C, and the flow extract is baked. The box is heated and dried, and the drying temperature is controlled to be 65 ° C to obtain a flower and fruit extract;
  • T2 Weigh the following components by weight: 200 parts of vitamin C sodium, 30 parts of taurine, 30 parts of zinc gluconate, 20 parts of flower and fruit extract, 120 parts of tartaric acid, 130 parts of sodium hydrogencarbonate, aspartame 30 parts; further weigh 0.5% of the total weight of the components of trehalose and 0.3% of the total weight of the components of lactose;
  • T3 Take 1/2 of the total weight of tartaric acid, flower and fruit extract, 1/2 of the total weight of trehalose, aspartame, mix, spray 60% ethanol solution, mix, granulate, pass 14 mesh sieve Dry at 80 ° C, whole grain, acidifier;
  • T4 Take 1/2 of the total weight of sodium bicarbonate, flower and fruit extract, 1/2 of the total weight of trehalose, mix, spray 60% ethanol solution, mix, granulate, pass 14 mesh sieve, 80 ° C Drying, granules, alkali agent;
  • T5 Take vitamin C sodium, taurine, zinc gluconate, acid, alkali, lactose, mix, tablet, that is.

Abstract

本发明公开了一种增强免疫力的泡腾片，该泡腾片包括以下重量份的组分：维生素C钠50-200份、牛磺酸10-30份、葡萄糖酸锌10-30份、花果提取物10-20份。本发明针对现有含维生素C泡腾片溶解后酸性大、对口腔、咽喉食道以及胃粘膜刺激较大、不宜长期服用，及存储过程中维生素C容易氧化失效，泡腾片易受潮吸湿等问题，提供一种具有具有增强免疫力、清热解毒、补肾健脾、美容养颜等功效，还可以补充人体所需的营养、缓解疲劳、延缓衰老的泡腾片。

Description

一种增强免疫力的泡腾片及其制备方法 技术领域
本发明属于药品、保健食品、食品领域，涉及一种组合物制剂及其制备方法，特别是涉及一种增强免疫力的泡腾片及其制备方法。
背景技术
现代人由于工作繁忙、平时饮食的不注意等原因，导致很多人的免疫力低下，身体都处于亚健康状态，如不注意将会发展为疾病甚至危及生命。随着生活水平的提高，人们对健康也日益重视，故希望使用的产品也是安全有效的，而“药食同源”类中药以及一些具有保健作用的瓜果符合人们的治疗疾病、保健需求。本发明在西药的基础上加入合适的“药食同源”类中药以及保健作用极佳的水果，制成一种增强免疫力的泡腾片，此泡腾片含有丰富的营养物质及改善人体健康的有效成分，具有增强免疫力、清热解毒、补肾健脾、美容养颜等功效，还可以补充人体所需的营养、缓解疲劳、延缓衰老，特别针对中老年人的健体美颜、抗衰老以及免疫力低下的癌症患者的康复。
维生素C是临床基本常用药物或营养补充剂，是抗氧化维生素当中的一种，它参与体内羟化反应，为形成骨骼、牙齿、结缔组织及非上皮组织细胞间粘物所必需，可维持牙齿、骨骼、血管的正常功能，增加对疾病的抵抗能力，为人体必需的营养元素之一，广泛应用于多种疾病预防和治疗。维生素C钠是维生素C的钠盐，水溶液pH值接近中性，它的作用与维生素C相同，但由于是钠盐，所以性能更稳定，同时不再有维生素C的强酸性，可以长期与多种药物同时服用，更优于维生素C。
泡腾片是近年来国外开发应用的一种新颖片剂。它与普通片剂的不同之处，就在于它还含有泡腾崩解剂，当泡腾片放入饮水中之后，在泡腾崩解剂的作用下，即刻产生大量气泡，使片剂迅速崩解和融化，有时崩解产生的气泡还会使药片在水中上下翻滚，加速其崩解和融化。片剂崩解时产生的气体部分溶解于饮水中，使饮水喝入口中时有汽水般的美感。泡腾片有如下的优点：便于保存和携带；崩解快速、服用方便、起效迅速；生物利用度高，能提高临床疗效；特别适用于儿童、老年人以及吞服药丸困难的患者；经过调味后的泡腾片，口味更佳，良药不再苦口，使消费者或病人更乐于接受。
发明内容
本发明针对现有含维生素C泡腾片溶解后酸性大、对口腔、咽喉食道以及胃粘膜刺激较大、不宜长期服用，及存储过程中维生素C容易氧化失效、泡腾片易吸湿导致片剂崩解不良 等问题，提供一种增强免疫力同时具有清热解毒、补肾健脾、美容养颜等功效的泡腾片及其制备方法，解决了临床上应用维生素C存在的质量不稳定、不易长期服用的等问题。本发明增强免疫力的泡腾片，安全、无毒副作用，可长期用于改善免疫力低下以及中老年人的健体美颜、抗衰老；或作为营养补充剂长期服用。
为解决上述技术问题，本发明是通过以下技术方案实现的：
一种增强免疫力的泡腾片，包括以下重量份的组分：维生素C钠50-200份、牛磺酸10-30份、葡萄糖酸锌10-30份、花果提取物10-20份。
以上所述花果提取物由以下重量份的原料制成：密蒙花30-50份、鲜桑葚30-60份、鲜葡萄5-10。
以上所述花果提取物的制备方法为：
S1：按以下重量份称取原料：密蒙花30-50份、鲜桑葚30-60份、鲜葡萄5-10份；
S2：取称量好的密蒙花，加6-10倍量水，浸泡30分钟，提取2-3次，每次30-40分钟，滤过，得花提取液；
S3：取称量好的鲜桑葚、鲜葡萄，洗净，榨取原汁，滤过，得果汁；
S4：将花提取液与果汁混合，80℃以下减压浓缩，得60℃时相对密度为1.18-1.22的流浸膏，将流浸膏进行干燥，控制干燥温度为65-80℃，得花果提取物。
所述步骤S2项下提取方法优选为加热回流提取、超声提取。
所述步骤S4项下干燥方法优选为烘箱加热干燥、喷雾干燥。
以上所述的增强免疫力的泡腾片，优选还包括以下重量份的组分：酒石酸50-120份、碳酸氢钠50-130份、阿斯巴甜10-30份。
以上所述的增强免疫力的泡腾片，进一步优选还包括占以上所述组分总重量0.5-1.0％的海藻糖及占以上所述组分总重量0.3-0.5％的乳糖。
以上所述的增强免疫力的泡腾片，最佳优选包括以下重量份的组分：维生素C钠120份、牛磺酸20份、葡萄糖酸锌20份、花果提取物15份、酒石酸80份、碳酸氢钠90份、阿斯巴甜20份，还包括占以上所述组分总重量0.8％的海藻糖及占以上所述组分总重量0.4％的乳糖。
以上所述花果提取物由以下重量份的原料制成：密蒙花40份、鲜桑葚50份、鲜葡萄8份。
以上所述增强免疫力的泡腾片的制备方法，包括如下步骤：
T1：花果提取物的制备：按重量份称取以下原料：密蒙花30-50份、鲜桑葚30-60份、鲜葡萄5-10份；取称量好的密蒙花，加6-10倍量水，浸泡30分钟，提取2-3次，每次30-40 分钟，滤过，得花提取液；取称量好的鲜桑葚、鲜葡萄，洗净，榨取原汁，滤过，得果汁；将花茶提取液与果汁混合，80℃以下减压浓缩，得60℃时相对密度为1.18-1.22的流浸膏，将流浸膏进行干燥，控制干燥温度为65-80℃，得花果提取物；
T2：按重量份称取以下组分：维生素C钠50-200份、牛磺酸10-30份、葡萄糖酸锌10-30份、花果提取物10-20份、酒石酸50-120份、碳酸氢钠50-130份、阿斯巴甜10-30份；再称取占所述组分总重量0.5-1.0％的海藻糖及占所述组分总重量0.3-0.5％的乳糖；
T3：取酒石酸、花果提取物总重量的1/2、海藻糖总重量的1/2、阿斯巴甜，混匀，喷入50-60％乙醇溶液，混匀，制粒，过筛，干燥，整粒，得酸剂；
T4：取碳酸氢钠、花果提取物总重量的1/2、海藻糖总重量的1/2，混匀，喷入50-60％乙醇溶液，混匀，制粒，过筛，干燥，整粒，得碱剂；
T5：取维生素C钠、牛磺酸、葡萄糖酸锌、酸剂、碱剂、乳糖，混匀，压片，即得。
所述步骤T3、T4项下干燥的温度优选为80℃以下,这样得到的颗粒硬度适中，更有利于压片，同时利用崩解；所述步骤T3、T4项下所述的过筛步骤所用的筛网优选为14-30目。
本发明的有益效果是：
1.本发明克服现有含维生素C泡腾片溶解后酸性大、对口腔、咽喉食道以及胃粘膜刺激较大、不宜长期服用，及存储过程中维生素C容易氧化失效、泡腾片易吸湿受潮等问题，使产品稳定性更好，疗效更确切，适用于消费者或患者长期服用，无副作用。
2.本发明方中花果提取物的各原料均为“药食同源”品种和日常食用水果，安全无毒副作用。其中密蒙花，味甘，性微寒，归肝经，含多种氨基酸、维生素、微量元素、黄酮及其苷类、三萜皂苷、黄色素等成分，能清肝火，养肝润燥，而明目退翳；桑葚，味甘，性寒，含有丰富的活性蛋白、维生素、氨基酸、胡萝卜素、矿物质、黄酮等多种活性成分，具有增强人体免疫力、营养肌肤、延缓衰老、生津止渴、促进消化、补肝益肾、滋阴补血等功效，被称为“民间圣果”；葡萄，含有多种矿物质、维生素以及人体所需的氨基酸，具有抗衰老、缓解疲劳、健脾胃、预防血栓、缓解低血糖等作用，由于其营养价值高，葡萄汁被科学家誉为“植物奶”；以上三种原料，通过合理配制，气味芳香、口感好，具有增强免疫力、清热解毒、补肾健脾、美容养颜等功效，还可以补充人体所需的营养、缓解疲劳、延缓衰老，特别针对中老年人的健体美颜、抗衰老以及免疫力低下的癌症患者的康复。
3.本发明增强免疫力的泡腾片，制剂简便，颗粒流动性好，压片不粘冲，所制得的片剂表面光滑，不易吸湿，泡腾产气均匀，崩解时间短，崩解后溶液透明澄清，口感香甜，质量稳定，携带方便，兼具了固体制剂和液体制剂的特点，尤其适用于儿童、老年人和不能吞咽 固体制剂的患者，生物利用度高，使用更安全有效，可作为营养补充液长期服用。
具体实施方式
虽然本说明书通过特别指出并清楚要求保护本发明的权利要求书作出结论，但应该相信下列说明将更好地理解本发明。
如本文所用，单词“优选”及变体是指在特定环境下能够提供特定有益效果的本发明的实施方案。然而，其它的实施方案在相同或其它的环境下也可以是优选的。此外，一个或多个优选实施方案的详述并不表示其它实施方案是无用的，并且不旨在从本发明的范畴排除其它的实施方案。
一、制剂条件筛选
1.酸源和碱源的选择
泡腾片中常用的酸源有酒石酸、柠檬酸、富马酸、己二酸、苹果酸等；碱源有碳酸氢钠、碳酸钾、碳酸氢钾、碳酸钙等。用碳酸氢钠作为碱源制成的泡腾片在水中能迅速崩解，且泡腾溶液的pH值适宜维生素C钠的稳定，故本发明碱源选择碳酸氢钠。在固定碱源为碳酸氢钠的基础上，按下表1中的配方对酒石酸、柠檬酸、富马酸、苹果酸、己二酸进行选择试验，以确定泡腾片中最佳的酸源种类。
表1酸源和碱源优选试验
Figure PCTCN2017114292-appb-000001
从表1中的试验结果可知:本发明使用酒石酸与维生素C钠、碳酸氢钠、阿斯巴甜混和，好制粒，腾崩解时间短，溶液澄清，口感好，只是压片时有粘冲现象，相比其他酸源最好，故本发明酸源选择酒石酸，碱源选择碳酸氢钠。
2.粘合剂选择
本发明对比了干法压片、湿法制粒再压片，干法压片采用普通压片机效果不好，对设备要求高，故本发明采用湿法制粒再压片。试验中对比了30％淀粉浆、40％蔗糖糖浆、5％羟丙甲纤维素水溶液、55％乙醇做粘合剂，结果见表2。
表2粘合剂考察结果表
Figure PCTCN2017114292-appb-000002
Figure PCTCN2017114292-appb-000003
从表2中的试验结果可知:本发明使用55％乙醇制粒情况及泡腾效果最好，故本发明粘合剂选择55％乙醇。为进一步优化乙醇浓度，本发明继续优化乙醇浓度，试验结果见表3。
表3乙醇浓度考察结果表
序号 粘合剂 制粒情况 颗粒外观 泡腾效果
1 20％乙醇 不成团，制粒困难 颗粒松 泡腾崩解时间3分钟，溶液澄清
2 30％乙醇 不成团，制粒困难 颗粒松紧合适 泡腾崩解时间3分钟，溶液澄清
3 50％乙醇 成团，制粒不结块 颗粒松紧合适 泡腾崩解时间3.5分钟，溶液澄清
4 60％乙醇 成团，制粒不结块 颗粒松紧合适 泡腾崩解时间4分钟，溶液澄清
5 70％乙醇 成团，制粒结块 颗粒紧 泡腾崩解时间6.5分钟，溶液澄清
从表3中的试验结果可知:本发明使用50％-60％乙醇制粒情况及泡腾效果较好，浓度低太松，浓度太高影响泡腾时间，故本发明粘合剂选择50％-60％乙醇。
3.稳定剂的选择
维生素C钠是维生素C的钠盐，性能较维生素C更稳定，但制备成泡腾片剂，在酸剂、碱剂、其他辅料及空气中水分及氧化等的影响，要在保质期内保证产品的质量稳定，还是需要加入稳定剂。试验中对比了0.02％EDTA二钠、1％海藻糖、0.2％亚硫酸钠，将分别用上述稳定剂制成的样品，分别用铝塑复合膜包装好，置稳定性加速试验箱内试验:温度：40±2℃，相对湿度：75±5％，加速试验3个月，试验结果见表4。
表4稳定剂试验结果表
Figure PCTCN2017114292-appb-000004
从表4中的试验结果可知:采用EDTA二钠及亚硫酸钠作为稳定剂，含水量变化较大，容 易造成酸剂碱剂内部反应，溶液pH降低及加速氧化，导致维生素C钠含量降低。以1％海藻糖为稳定剂，加速试验后，水分变化不大，外观、泡腾反应时间、溶液pH及维生素C钠含量变化小，故本发明使用1％海藻糖作为稳定剂，为此，进一步考察海藻糖的加入量并将所得样品进行加速试验，试验方法同表4，结果详见表5。
表5海藻糖的加入量试验结果表
Figure PCTCN2017114292-appb-000005
从表5中的试验结果可知:加入0.2-0.4％海藻糖后泡腾片的水分、外观、泡腾反应时间、溶液pH及维生素C钠含量变化均较大；而含0.5-1.0％海藻糖的泡腾片各项理化指标在3个月的加速时间内变化小，质量稳定；含1.2-1.5％海藻糖的泡腾片在3个月的加速时间内外观、pH值、含量指标变化不大，3个月加速时间内质量仍稳定，但水分、泡腾反应时间变化超出 质量标准规定。故本发明控制海藻糖的加入量为0.5-1.0％。
4.润滑剂的选择
本发明在压片前的物料有酸剂、维生素C钠、甜味剂、碱剂，物料颗粒大小、质地不均，压片时出现颗粒流动性差、压片时易粘冲等现象。本发明试验中除润滑剂外其余配方相同，经初步试验确定可用比例后，具体对比了不同加入量的十二烷基硫酸镁、乳糖、甘露醇，并将分别用上述润滑剂制成的样品，分别用铝塑复合膜包装好，置稳定性加速试验箱内试验:温度：40±2℃，相对湿度：75±5％，加速试验3个月，结果见表6。
表6润滑剂试用结果表
Figure PCTCN2017114292-appb-000006
从表6中的试验结果可知:加入0.3-0.5％乳糖的流动性好，且压片不粘冲，片面光滑美观，但加速试验发现，加入乳糖量增加，含水量增加，泡腾反应时间也增加很多，不符合泡腾剂崩解时间要求，故本发明选用0.3-0.5％的乳糖作为润滑剂。
二、缓解视疲劳的组合物的制备方法
实施例1
增强免疫力的泡腾片的制备方法，包括如下步骤：
T1：花果提取物的制备：按重量份称取以下原料：密蒙花40份、鲜桑葚50份、鲜葡萄8份；取称量好的密蒙花，加8倍量水，浸泡30分钟，加热回流提取3次，每次30分钟，滤过，得花提取液；取称量好的鲜桑葚、鲜葡萄，洗净，榨取原汁，滤过，得果汁；将花提取液与果汁混合，80℃以下减压浓缩，得60℃时相对密度为1.20的流浸膏，将流浸膏进行喷 雾干燥，控制干燥温度为70℃，得花果提取物；
T2：按重量份称取以下组分：维生素C钠120份、牛磺酸20份、葡萄糖酸锌20份、花果提取物15份、酒石酸80份、碳酸氢钠90份、阿斯巴甜20份；再称取占所述组分总重量0.5％的海藻糖及占所述组分总重量0.3％的乳糖；
T3：取酒石酸、花果提取物总重量的1/2、海藻糖总重量的1/2、阿斯巴甜，混匀，喷入55％乙醇溶液，混匀，制粒，过20目筛，80℃下干燥，整粒，得酸剂；
T4：取碳酸氢钠、花果提取物总重量的1/2、海藻糖总重量的1/2，混匀，喷入55％乙醇溶液，混匀，制粒，过20目筛，80℃下干燥，整粒，得碱剂；
T5：取维生素C钠、牛磺酸、葡萄糖酸锌、酸剂、碱剂、乳糖，混匀，压片，即得。
实施例2
增强免疫力的泡腾片的制备方法，包括如下步骤：
T1：花果提取物的制备：按重量份称取以下原料：密蒙花30份、鲜桑葚30份、鲜葡萄5份；取称量好的密蒙花，加6倍量水，浸泡30分钟，超声提取3次，每次30分钟，滤过，得花提取液；取称量好的鲜桑葚、鲜葡萄，洗净，榨取原汁，滤过，得果汁；将花提取液与果汁混合，80℃以下减压浓缩，得60℃时相对密度为1.18的流浸膏，将流浸膏进行喷雾干燥，控制干燥温度为80℃，得花果提取物；
T2：按重量份称取以下组分：维生素C钠50份、牛磺酸10份、葡萄糖酸锌10份、花果提取物10份、酒石酸50份、碳酸氢钠50份、阿斯巴甜10份；再称取占所述组分总重量0.5％的海藻糖及占所述组分总重量0.3％的乳糖；
T3：取酒石酸、花果提取物总重量的1/2、海藻糖总重量的1/2、阿斯巴甜，混匀，喷入50％乙醇溶液，混匀，制粒，过30目筛，80℃下干燥，整粒，得酸剂；
T4：取碳酸氢钠、花果提取物总重量的1/2、海藻糖总重量的1/2，混匀，喷入50％乙醇溶液，混匀，制粒，过30目筛，80℃下干燥，整粒，得碱剂；
T5：取维生素C钠、牛磺酸、葡萄糖酸锌、酸剂、碱剂、乳糖，混匀，压片，即得。
实施例3
增强免疫力的泡腾片的制备方法，包括如下步骤：
T1：花果提取物的制备：按重量份称取以下原料：密蒙花50份、鲜桑葚60份、鲜葡萄10份；取称量好的密蒙花，加10倍量水，浸泡30分钟，加热回流提取2次，每次40分钟，滤过，得花提取液；取称量好的鲜桑葚、鲜葡萄，洗净，榨取原汁，滤过，得果汁；将花提取液与果汁混合，80℃以下减压浓缩，得60℃时相对密度为1.22的流浸膏，将流浸膏放时烘 箱进行加热干燥，控制干燥温度为65℃，得花果提取物；
T2：按重量份称取以下组分：维生素C钠200份、牛磺酸30份、葡萄糖酸锌30份、花果提取物20份、酒石酸120份、碳酸氢钠130份、阿斯巴甜30份；再称取占所述组分总重量0.5％的海藻糖及占所述组分总重量0.3％的乳糖；
T3：取酒石酸、花果提取物总重量的1/2、海藻糖总重量的1/2、阿斯巴甜，混匀，喷入60％乙醇溶液，混匀，制粒，过14目筛，80℃下干燥，整粒，得酸剂；
T4：取碳酸氢钠、花果提取物总重量的1/2、海藻糖总重量的1/2，混匀，喷入60％乙醇溶液，混匀，制粒，过14目筛，80℃下干燥，整粒，得碱剂；
T5：取维生素C钠、牛磺酸、葡萄糖酸锌、酸剂、碱剂、乳糖，混匀，压片，即得。
三、稳定性试验
将上述实施例1-3样品分别用铝塑复合膜包装好，置稳定性加速试验箱内试验:温度：40±2℃，相对湿度：75±5％，加速试验3个月，结果实施例1-3样品的外观性状、水分、泡腾反应时间、溶液pH值、主要成分含量等稳定性重点考察指标与0时样品测定结果比较，均无明显变化，说明本发明实施例1-3样品质量较为稳定，可满足贮存、运输、使用的稳定性要求。试验结果见表7。
表7缓解视疲劳的泡腾片稳定性试验结果表
Figure PCTCN2017114292-appb-000007

Claims (9)

  1. 一种增强免疫力的泡腾片，其特征在于，包括以下重量份的组分：维生素C钠50-200份、牛磺酸10-30份、葡萄糖酸锌10-30份、花果提取物10-20份；
    所述花果提取物由以下重量份的原料制成：密蒙花30-50份、鲜桑葚30-60份、鲜葡萄5-10份。
  2. 如权利要求1所述的增强免疫力的泡腾片，其特征在于，所述花果提取物的制备方法为：
    S1：按以下重量份称取原料：密蒙花30-50份、鲜桑葚30-60份、鲜葡萄5-10份；
    S2：取称量好的密蒙花，加6-10倍量水，浸泡30分钟，提取2-3次，每次30-40分钟，滤过，得花提取液；
    S3：取称量好的鲜桑葚、鲜葡萄，洗净，榨取原汁，滤过，得果汁；
    S4：将花提取液与果汁混合，80℃以下减压浓缩，得60℃时相对密度为1.18-1.22的流浸膏，将流浸膏进行干燥，控制干燥温度为65-80℃，得花果提取物。
  3. 如权利要求2所述的缓解视疲劳的组合物，其特征在于，步骤S2项下提取方法为加热回流提取、超声提取。
  4. 如权利要求2所述的缓解视疲劳的组合物，其特征在于，步骤S4项下干燥方法为烘箱加热干燥、喷雾干燥。
  5. 一种如权利要求1所述的增强免疫力的泡腾片，其特征在于，还包括以下重量份的组分：酒石酸50-120份、碳酸氢钠50-130份、阿斯巴甜10-30份。
  6. 如权利要求5所述的增强免疫力的泡腾片，其特征在于，还包括占以上所述组分总重量0.5-1.0％的海藻糖及占以上所述组分总重量0.3-0.5％的乳糖。
  7. 一种如权利要求6所述的增强免疫力的泡腾片的制备方法，其特征在于，包括以下步骤：
    T1：花果提取物的制备：按重量份称取以下原料：密蒙花30-50份、鲜桑葚30-60份、鲜葡萄5-10份；取称量好的密蒙花，加6-10倍量水，浸泡30分钟，提取2-3次，每次30-40分钟，滤过，得花提取液；取称量好的鲜桑葚、鲜葡萄，洗净，榨取原汁，滤过，得果汁；将花提取液与果汁混合，80℃以下减压浓缩，得60℃时相对密度为1.18-1.22的流浸膏，将流浸膏进行干燥，控制干燥温度为65-80℃，得花果提取物；
    T2：按重量份称取以下组分：维生素C钠50-200份、牛磺酸10-30份、葡萄糖酸锌10-30份、花果提取物10-20份、酒石酸50-120份、碳酸氢钠50-130份、阿斯巴甜10-30份；再称取占所述组分总重量0.5-1.0％的海藻糖及占所述组分总重量0.3-0.5％的乳糖；
    T3：取酒石酸、花果提取物总重量的1/2、海藻糖总重量的1/2、阿斯巴甜，混匀，喷入50-60％乙醇溶液，混匀，制粒，过筛，干燥，整粒，得酸剂；
    T4：取碳酸氢钠、花果提取物总重量的1/2、海藻糖总重量的1/2，混匀，喷入50-60％乙醇溶液，混匀，制粒，过筛，干燥，整粒，得碱剂；
    T5：取维生素C钠、牛磺酸、葡萄糖酸锌、酸剂、碱剂、乳糖，混匀，压片，即得。
  8. 如权利要求5所述的增强免疫力的泡腾片的制备方法，其特征在于，步骤T3、T4项下干燥的温度为80℃以下。
  9. 如权利要求5所述的增强免疫力的泡腾片的制备方法，其特征在于，步骤T3、T4项下所述的过筛步骤所用的筛网为14-30目。
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